CN103191459B - Composite silica gel protective dressing and preparation method thereof - Google Patents
Composite silica gel protective dressing and preparation method thereof Download PDFInfo
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- CN103191459B CN103191459B CN201310115112.7A CN201310115112A CN103191459B CN 103191459 B CN103191459 B CN 103191459B CN 201310115112 A CN201310115112 A CN 201310115112A CN 103191459 B CN103191459 B CN 103191459B
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- lysine
- silicon gel
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- tea polyphenols
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Abstract
The invention relates to medical composite silica gel protective dressing and a preparation method thereof. The method comprises the concrete steps of 1) adding lysine and tea polyphenol to deionized water to dissolve according to a certain ratio, evenly agitating to prepare mixed solution of lysine and tea polyphenol; 2) adding silica sol to the mixed solution of lysine and tea polyphenol; 3) adding a certain amount of surfactant to the mixed solution of lysine and tea polyphenol to evenly mix, thereby obtaining the composite silica gel; and 4) centrifuging and dewatering the composite silica gel, and thoroughly cleaning a filter cake by the deionized water, and crushing to obtain the composite silica gel powder, adding the powder to distilled water of which the mass ratio to the powder is 1.5 to 1, and evenly heating and mixing at the temperature of 40-60 DEG C to obtain the composite silica gel protective dressing under an agitation state, and preparing the composite silica gel protective dressing into a patch according to a common technology. The prepared protective dressing can effectively prevent bacterium and sterilize the wound surface, so as to relieve itching of the wound surface when effectively preventing and treating various scars after operations, trauma and burn. Thus, use of a receptor is greatly facilitated.
Description
Technical field
The present invention relates to a kind of medical comprehensive silicon gel and protect wound dressing and preparation method thereof, particularly a kind of have the promoted wound healing of anti-inflammation function and remove silicon gel of scar function and preparation method thereof.
Background technology
Significantly skin wound, as damage or the caused wound of performing the operation, often causes cicatrization.Cicatrix causes sense of touch to reduce under many circumstances, and flexible forfeiture and range of movement are lost.Particularly when at face with on hand time, cicatrization also causes obvious aesthetic problem.Skin wound is also easy to infect, and uses conventional dressing, infects also quite general.Fire victim is especially easily infected, and may leave serious cicatrization in the time of wound healing.Method to the treatment skin injury that minimizes or eliminate cicatrization is sought in demand.
At present on the market except scar product a lot, the patent that wherein application number is 201010563028.8 discloses a kind of preparation technology that wound is applied ointment or plaster that protects, this wound of protecting is applied ointment or plaster and is mainly existed with the form of hydrogel, its composition mainly comprises chitosan, Oligomeric maltose, Oleum menthae, P-hydroxybenzoic acid, glycerol, polyvinylpyrrolidone and polyacrylic acid and water composition.Application number is that 201110187629.8 patent discloses a kind of curable silicon gel combination, and the main component of said composition comprises organopolysiloxane, organic hydrogen polysiloxanes, platinum-catalyst based.The patent No. is the preparation method that the patent of ZL 200410096766.0 discloses a kind of silicon gel carrying silver ion, and the method mainly joins Ludox in the silver nitrate solution that contains surfactant, obtains silicon gel carrying silver ion.It is a kind of for wound healing with reduce the compositions based on silicon gel of cicatrix that application number is 200880109515.8 international patent publications, and said composition mainly comprises annular siloxane, siloxanes confining liquid, siloxanes sealing gel and silicone resin powder.
Can show that from above patented technology silicon gel-like is except scar product is at wound healing with except having accounted for leading position scar product.But the silicate gel film of preventing and treating at present scar hyperplasia uses after being wound healing cicatrization, be not suitable in art and cicatrizing date uses, it is used for the treatment of both established cicatrixs, and effect is not good enough.
Along with to wound healing and except the physiopathologic further investigation of scar process, people to wound healing and except the understanding of scar process also more and more deep, thereby make Medical wounded surface dressing update and develop.Be incorporated in silicon gel though current technical research has had silver ion etc. the metal ion of antibacterial functions, to increase the antibacterial functions except scar product, but the prepared product cost of this method is higher, for enterprise and patient bring larger economic pressures.
Lysine is the seed amino acid that human body needs, a kind of indispensable nutrient substance, has and can improve intelligence, promote growth, health invigorating, appetite stimulator, improves malnutrition situation, improve insomnia, improve memory, help to produce antibody, hormone and enzyme, improve immunity, increase hematochrome, help the absorption of calcium, treatment prevents osteoporosis, reduces the level of triglyceride in blood, the generation of prevention cardiovascular and cerebrovascular disease.Tea polyphenols itself has very strong anti-oxidation function and antibacterial functions, its oxidation resistance is synthetic antioxidant BHT and BHA 4-6 times, be the 6-7 of VE doubly, and consumption is few, without the potential toxic and side effects of synthetic, so be introduced into the effect that both can reach the antibiotic property that strengthens silicon gel itself in silicon gel, antiinflammatory and the pot-life that can improve again product.But before the present invention, nobody sets forth or recognizes that lysine and tea polyphenols have huge potentiality aspect wound, and can become the powerful mean of resisting antibacterial existence and growth, and that the existence of antibacterial and growth are traumatic infections is the most common the most fatal, and nobody recognizes that can produce suitable Wound care infects the most common the most fatal, and nobody recognizes and can produce suitable wound care products to realize this object, with application disinfectant and toxic metal Ion Phase ratio, when realizing object, do not exist and make bacterial antibiotic produce multidrug resistant danger, or do not exist organizing hurtful danger.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of promoted wound healing with anti-inflammation function and except comprehensive silicon gel of scar function and preparation method thereof, the method is mainly that lysine and the tea polyphenols with anti-inflammation function are incorporated in silicon gel, prepare a kind of method of medical comprehensive silicon gel, this technique is simple, cost is low, with short production cycle, can produce in enormous quantities.
The present invention solves above technical problem with following technical scheme:
1) lysine and tea polyphenols are joined in deionized water and dissolved by a certain percentage, stir and be prepared into lysine and tea polyphenols mixed solution;
2) Ludox is joined in the mixed solution of lysine and tea polyphenols;
3) in the mixed solution of Ludox and lysine and tea polyphenols, add a certain amount of surfactant that it is mixed homogeneously, obtain comprehensive silicon gel;
4) by comprehensive silicon gel centrifugal dehydration, and thoroughly clean filter cake with deionized water, then pulverize, obtain comprehensive silicon gel powder body.By adding in this powder body with powder quality than being in the distilled water of 1.5 ﹕ 1, at 40～60 DEG C of temperature of stirring, heat mix homogeneously and obtain silicon gel dressing.
The present invention, described comprehensive silicon gel protects wound dressing, can prepare by the following method: 5～100g lysine and 2～30g tea polyphenols are joined in 1kg deionized water and dissolved, stir, make lysine and tea polyphenols mixed solution, under stirring, in described mixed solution, add Ludox 200mL, after 0.001～0.003g surfactant is dissolved in 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, Ludox is mixed homogeneously with lysine and tea polyphenols, obtain comprehensive silicon gel, then centrifuge dehydration, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, to in this powder body, add with powder quality than being in the distilled water of 1.5 ﹕ 1, at 40～60 DEG C of temperature of stirring, heating mix homogeneously obtains silicon gel and protects wound dressing.
The present invention, described surfactant is cationic surfactant polyacrylamide, zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone or anion surfactant dodecyl sodium sulfate.
The present invention, by described silicon gel dressing routinely technique prepare patch---Medical silicone gels scar plaster, for the ultimate principle of preventing and treat hypertrophic cicatrix be: the micromolecule silicone oil of silicon gel is penetrated into cicatrix position, form hydrated collagen with collagen protein, make the deliquescing of cicatrix position, color is thin out.Rely on the pressure of paster to skin, the undue growth of blocking-up collagen fiber, prevents hypertrophic cicatrix simultaneously.Therefore, the key factor of scar plaster prevention and treatment hypertrophic cicatrix is micromolecule silicone oil and pressure.
The present invention, using silicon gel as carrier, lysine is introduced after silicon gel, its anti-microbial property increases, this be mainly because, when introduce lysine in silicon gel after, can increase the amino density of silicon gel surface, so increase the positive charge density of silicon gel surface, thereby increase the cohesion of its antibacterial that wound surface is existed with negative charge form, stick in the time of wound surface, be adsorbed in wound surface surface, make wound surface and the isolation of extraneous antibacterial, thereby stop pathogenic bacteria field planting, promote blood coagulation, thereby accelerate the reparation of wound surface.
The present invention, the tea polyphenols using is natural strong oxidizer, can effectively remove the unnecessary oxygen-derived free radicals producing in skin, suppresses to cause scorching bacterium and pro-inflammatory cytokine in skin, and scytitis is had to good therapeutical effect.
The present invention, comprehensive silicon gel prepared therefrom is except scar product, overcome in prior art product function single and introduce heavy metal ion and easily increase user skin damage, the defect of heavy metal poisoning and drug anaphylaxis, make more wound apply ointment or plaster effectively preventing and treat after operation, wound and burn in all kinds of cicatrixes, wound surface is carried out to effectively antibacterial, sterilization, make wound surface antipruritic, greatly facilitate receptor to use.
Detailed description of the invention
Embodiment 1: 5g lysine and 2g tea polyphenols are joined in 1kg deionized water and dissolved, stir, make lysine and tea polyphenols mixed solution, under stirring, in above mixed solution, add Ludox 200mL, after 0.001g cationic surfactant polyacrylamide is dissolved in 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, Ludox is mixed homogeneously with lysine and tea polyphenols, obtain comprehensive silicon gel, then centrifuge dehydration, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, to in this powder body, add with powder quality than being in the distilled water of 1.5 ﹕ 1, at 40 DEG C of temperature of stirring, heating mix homogeneously obtains comprehensive silicon gel and protects wound dressing.By this comprehensive silicon gel protect wound dressing routinely technique make patch, after healing completely for wound surface the patient of about 1 week try out.When use, first with warm water, affected part is cleaned gently and wiped dry, by affixed in affected part silicon gel pad pasting, naturally bonding, used continuously 12 hours every day.After 1 week, the most of sufferings symptom of this patient is eased.Further consultation joint part cicatrix softness after two months, function effect little (being obviously better than without pad pasting person from clinical experience judgement), and be reduced to 6.0mm by the thickness of 10MHZ B ultrasonic detection cicatrix by original 6.8mm.
Embodiment 2: 100g lysine and 30g tea polyphenols are joined in 1kg deionized water and dissolved, make lysine and tea polyphenols mixed solution, and in above mixed solution, add Ludox 200mL under stirring, after 0.003g zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone is dissolved in 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, Ludox is mixed homogeneously with lysine and tea polyphenols, obtain comprehensive silicon gel, then centrifuge dehydration, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, to in this powder body, add with powder quality than being in the distilled water of 1.5 ﹕ 1, at 60 DEG C of temperature of stirring, heating mix homogeneously obtains comprehensive silicon gel and protects wound dressing.By this comprehensive silicon gel protect wound dressing routinely technique make patch, after healing completely for wound surface the patient of about 1 week try out.When use, first with warm water, affected part is cleaned gently and wiped dry, by affixed in affected part silicon gel pad pasting, naturally bonding, used continuously 12 hours every day.After 1 week, the most of sufferings symptom of this patient is eased.Further consultation joint part cicatrix softness after two months, function effect little (being obviously better than without pad pasting person from clinical experience judgement), and be reduced to 3.5mm by the thickness of 10MHZ B ultrasonic detection cicatrix by original 4.9mm.
Embodiment 3: 50g lysine and 15g tea polyphenols are joined in 1kg deionized water and dissolved, make lysine, tea polyphenols mixed solution, and in above mixed solution, add Ludox 200mL under stirring, after 0.003g anion surfactant dodecyl sodium sulfate is dissolved in 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, Ludox is mixed homogeneously with lysine and tea polyphenols, obtain comprehensive silicon gel, then centrifuge dehydration, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body.To in this powder body, add with powder quality than being in the distilled water of 1.5 ﹕ 1, at 50 DEG C of temperature of stirring, heat mix homogeneously and obtain comprehensive silicon gel and protect wound dressing.By this comprehensive silicon gel protect wound dressing routinely technique make patch, after healing completely for wound surface the patient of about 1 week try out.When use, first with warm water, affected part is cleaned gently and wiped dry, by affixed in affected part silicon gel pad pasting, naturally bonding, used continuously 12 hours every day.After 1 week, the most of sufferings symptom of this patient is eased.Further consultation joint part cicatrix softness after two months, function effect little (being obviously better than without pad pasting person from clinical experience judgement), and be reduced to 5.2mm by the thickness of 10MHZ B ultrasonic detection cicatrix by original 5.4mm.
Claims (2)
1. comprehensive silicon gel protects a preparation method for wound dressing, it is characterized in that: comprise following processing step:
1) lysine and tea polyphenols are joined in deionized water and dissolved by a certain percentage, stir and make lysine and tea polyphenols mixed solution;
2) Ludox is joined in the mixed solution of lysine and tea polyphenols;
3) in the mixed solution of Ludox and lysine and tea polyphenols, add a certain amount of surfactant that it is mixed homogeneously, obtain comprehensive silicon gel;
4) by comprehensive silicon gel centrifugal dehydration, and thoroughly clean filter cake with deionized water, then pulverize, obtain comprehensive silicon gel powder body, this powder body is added with powder quality than being in the distilled water of 1.5 ﹕ 1, at 40～60 DEG C of temperature of stirring, heat mix homogeneously and obtain silicon gel and protect wound dressing
Its concrete preparation process is: 5～100g lysine and 2～30g tea polyphenols are joined in 1kg deionized water and dissolved, stir, make lysine and tea polyphenols mixed solution, under stirring, in described mixed solution, add Ludox 200mL, after 0.001～0.003g surfactant is dissolved in 10mL deionized water, join in the mixed solution of Ludox and lysine and tea polyphenols, Ludox is mixed homogeneously with lysine and tea polyphenols, obtain comprehensive silicon gel, then centrifuge dehydration, and thoroughly clean filter cake with deionized water, pulverize again, obtain comprehensive silicon gel powder body, this powder body is added with powder quality than being in the distilled water of 1.5 ﹕ 1, at 40～60 DEG C of temperature of stirring, heating mix homogeneously obtains silicon gel and protects wound dressing.
2. comprehensive silicon gel according to claim 1 protects the preparation method of wound dressing, it is characterized in that: described surfactant is cationic surfactant polyacrylamide, zwitterionic surfactant hexadecyldimethyl benzyl ammonium amine second lactone or anion surfactant dodecyl sodium sulfate.
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| CN201310115112.7A CN103191459B (en) | 2013-04-06 | 2013-04-06 | Composite silica gel protective dressing and preparation method thereof |
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| CN201310115112.7A CN103191459B (en) | 2013-04-06 | 2013-04-06 | Composite silica gel protective dressing and preparation method thereof |
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| CN103191459B true CN103191459B (en) | 2014-08-06 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103550828B (en) * | 2013-10-17 | 2016-01-27 | 中国科学院动物研究所 | A kind of skin renewal method based on hair follicle stem cells and Silica hydrogel dressing |
| CN104436290B (en) * | 2014-11-07 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Functional dressing for inhibiting scar hyperplasia and preparation method thereof |
| CN104814886A (en) * | 2015-04-10 | 2015-08-05 | 浙江省诸暨市珠力神医用品有限公司 | Silicon gel combination |
| CN107296975A (en) * | 2017-08-03 | 2017-10-27 | 江苏亿茂滤材有限公司 | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof |
| CN111068124B (en) * | 2018-10-19 | 2021-04-13 | 中山大学 | Polypropylene/tea polyphenol patch for intraperitoneal repair and preparation method and application thereof |
| CN111298199B (en) * | 2020-04-13 | 2020-12-01 | 中国医科大学附属第一医院 | Temporary implant for orthopedics department and preparation method thereof |
| CN113332488A (en) * | 2021-05-31 | 2021-09-03 | 南昌智产科技有限公司 | Medical silica gel foam dressing and preparation method thereof |
| CN116019963B (en) * | 2022-12-02 | 2023-09-22 | 江苏弘生生物工程有限公司 | Preparation method of medical silica gel foam dressing |
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| CN1274595C (en) * | 2004-12-07 | 2006-09-13 | 中国乐凯胶片集团公司 | Process for preparing silicon gel carrying silver ion |
| CN100512808C (en) * | 2005-10-19 | 2009-07-15 | 浙江杭康海洋生物药业有限公司 | Externally applied compound amino acid prepn for promoting wound healing and its preparation process and application thereof |
| ATE523210T1 (en) * | 2007-09-30 | 2011-09-15 | Meda Ab | SILICONE GEL-BASED COMPOSITIONS FOR WOUND HEALING AND SCARS REDUCTION |
| CN101156867A (en) * | 2007-10-19 | 2008-04-09 | 北京协和建昊医药技术开发有限责任公司 | Tea polyphenol pellicle and method for making same |
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