CN111068124B - Polypropylene/tea polyphenol patch for intraperitoneal repair and preparation method and application thereof - Google Patents
Polypropylene/tea polyphenol patch for intraperitoneal repair and preparation method and application thereof Download PDFInfo
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Abstract
The polypropylene in the polypropylene/tea polyphenol patch for intraperitoneal repair prepared by the invention has good tensile strength, chemical substance erosion resistance and light foreign body sensation, can promote the growth of fibroblast in an organism, has low price of tea polyphenol, good biological safety, stable property, good antibacterial property, hydrophilicity and biocompatibility, and safe performance, can prevent the problem of in vivo infection of an implant material, and remarkably reduces complications such as intestinal adhesion and the like caused by the contact of the polypropylene with abdominal organs.
Description
Technical Field
The invention relates to the technical field of medical materials and preparation thereof, in particular to a polypropylene/tea polyphenol patch for intraperitoneal repair and a preparation method and application thereof.
Background
After the self-repairing sheet material is applied to the hernia repair, the recurrence rate of abdominal wall hernia is obviously reduced, and the incidence rate of postoperative chronic pain is also reduced. Tensionless hernia repair has become a classic procedure widely used clinically, with millions of surgical patches being applied worldwide for repair of abdominal wall defects every day. The traditional tension-free hernia repair is to place a patch material outside the peritoneum, so that the safety problem of abdominal viscera is avoided. With medical advances, laparoscopic Intraperitoneal hernia repair (IPOM) has been shown to provide more benefit to patients, reducing the recurrence rate and the infection rate of incisions. The technology has gradually gained attention and acceptance of the majority of clinicians through the innovative development of more than ten years. However, the IPOM technique also presents new challenges for patch materials, which must be biocompatible anti-adhesion patches for intra-abdominal repair.
The patch for the abdominal cavity applied clinically comprises a biological patch and a synthetic patch, and most of the patches depend on imports, are expensive and have complex manufacturing process. Researches show that although the biological patch has a better anti-adhesion effect in the abdominal cavity, the risk of infection, patch displacement and contraction still exists, and compared with the synthetic patch, the biological patch has insufficient strength and high recurrence risk; while the synthetic patches still present varying degrees of risk of adhesion.
Most of the current anti-adhesion materials are developed based on polypropylene (PP), which benefits from the remarkably good properties of polypropylene: high tensile strength, resistance to chemical attack and good integration of granulation tissue. The PP material with light weight and large meshes has the advantages of light foreign body sensation, promotion of fibroblast growth in a body and the like, can well control the risks of infection and displacement of the patch, and has irreplaceable advantages. However, the pure PP patch for intra-abdominal repair has risks of organ adhesion, intestinal obstruction, intestinal fistula, sinus formation and the like. After the patch material is implanted into the body as a foreign body, the induction of chronic inflammatory reaction can cause fibroblast aggregation, adhesion formation and the like. Thus, a PP patch material with good biocompatibility cannot be used as an anti-adhesion patch. The intraperitoneal application of PP material was intensively investigated as a hot spot in the first world hernia surgery year held in milan in 2015, based on the excellent properties of PP material. The compounding of the anti-adhesion material on the basis of the PP material to reduce the complications related to the patch is a hotspot and difficulty in the current abdominal wall defect repair research.
The polydopamine is a hydrophilic and biocompatible macromolecule, can be oxidized and polymerized on the surface of a polypropylene material through dopamine, and has stable properties. The action mechanism of the dopamine-dopamine composite material is derived from catechol and amino functional groups of dopamine, the structure can establish covalent and non-covalent interaction with the surface of a polypropylene material, and the covalent and non-covalent interaction is stably attached and coated on the surface of the polypropylene material through complex physical and chemical effects to form a layer of polydopamine membrane, so that the polypropylene-polydopamine composite material can be used as an intraperitoneal repairing material. However, polypropylene-polydopamine composite materials still have certain disadvantages: dopamine is a neurotransmitter, has certain biological efficacy, has certain limitation and safety in vivo application, and simultaneously has expensive raw dopamine material and higher cost. Therefore, an anti-adhesion patch material with excellent performance, simple manufacturing process and low cost is required.
Disclosure of Invention
The invention aims to overcome at least one defect of the prior art and provides a preparation method of a polypropylene/tea polyphenol patch for intraperitoneal repair, and the patch prepared by the method has good mechanical property, biocompatibility, excellent anti-adhesion property and anti-infection property and low price.
Another object of the present invention is to provide a polypropylene/tea polyphenol patch for intraperitoneal repair.
Another object of the present invention is to provide the use of the polypropylene/tea polyphenol patch for intraperitoneal repair.
The technical scheme adopted by the invention is as follows:
a preparation method of polypropylene/tea polyphenol patch for intraperitoneal repair comprises the following steps:
step (1): preparing 50-200mmol/L N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution, adding tea polyphenol, and adjusting the dosage to obtain tea polyphenol with the solubility of 1.0-4.0 mg/mL;
step (2): after the tea polyphenol is completely dissolved, adding a polypropylene mesh into the solution, and stirring and reacting for 12-72 hours at the temperature of 10-40 ℃ in the air atmosphere;
and (3): taking out the polypropylene mesh, soaking in deionized water for 5-20min, washing with deionized water and anhydrous ethanol for 2-5 times, respectively, drying with inert gas to obtain polypropylene/tea polyphenol patch, and sealing in dark.
Tea polyphenol is a green plant extract, the performance is safe, the safety of application in human body has been proved and widely accepted, the tea polyphenol and dopamine have similar catechol structures, a polydopamine-like nano-film can be formed on the surface of the material, the nano-film is stably attached and coated on the surface of a polypropylene material through complex physical and chemical actions, the biological safety is good, the property is stable, the hydrophilic property and the biocompatibility are good, the polypropylene material does not directly contact abdominal organs, complications such as intestinal adhesion caused by the polypropylene contacting the abdominal organs can be greatly reduced, meanwhile, the tea polyphenol also has antibacterial performance, the problem of in-vivo infection of the implant material can be better prevented and treated, the tea polyphenol raw material is low in price and wide in source, belongs to green renewable resources, and has great application prospect.
The N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution acts to regulate and control the pH environment of the reaction, the reaction is carried out in the air atmosphere, the covalent and non-covalent interaction is established between the tea polyphenol and the surface of the polypropylene material, and the tea polyphenol is stably polymerized and attached to and coated on the surface of the polypropylene material through complex physical and chemical actions to form a layer of polymerized nano-film. The preparation method takes the traditional abdominal wall defect repair material as a raw material, the implementation process is simple and easy, the cost is low, and the obtained product has good mechanical property/biocompatibility and excellent anti-adhesion property.
Preferably, the concentration of the N, N-dihydroxyethylglycine-sodium hydroxide buffer solution is 100 mmol/L.
Preferably, step (2) is: after the tea polyphenol is completely dissolved, adding a polypropylene mesh into the solution, stirring and reacting at 25-30 ℃ in the air atmosphere at the rotation speed of 100-1000rpm for 30-50 h. More preferably, the rotation speed is 300-.
In the experimental process, the preparation process conditions are found to be regulated and controlled, such as: the reaction concentration, the reaction time, the reaction temperature, the stirring speed and the like of the tea polyphenol can effectively regulate and control the thickness of the obtained polymeric membrane.
More preferably, the rotation speed in step (2) is 400 rpm.
Preferably, the polypropylene mesh is a medical light-weight patch woven from polypropylene, and the polypropylene mesh can be used directly without any treatment after purchase. Preferably, the mesh diameter of the polypropylene mesh is 0.1mm-1 cm. The polypropylene mesh with the mesh diameter of 0.1mm-1cm is selected, so that the prepared polypropylene/tea polyphenol patch for intraperitoneal repair can keep a certain mesh structure, tissue ingrowth and free access of macrophages and leucocytes are facilitated, and the polypropylene/tea polyphenol patch has good tissue strength, tensile strength and infection resistance.
The polypropylene/tea polyphenol patch for intraperitoneal repair prepared by the method.
The invention also discloses application of the polypropylene/tea polyphenol patch for intraperitoneal repair in hernia repair. The polypropylene in the polypropylene/tea polyphenol patch for intraperitoneal repair has good tensile strength, chemical substance erosion resistance and light foreign body sensation, and can promote fibroblast of an organism to grow in, the tea polyphenol coated on the surface of the polypropylene has good antibacterial property, hydrophilicity and biocompatibility, and the performance is safe, so that the polypropylene patch can prevent and treat the problem of in-vivo infection of an implant material, remarkably reduce intestinal adhesion and other complications caused by the contact of the polypropylene with abdominal organs, has almost no potential safety hazard, and can be applied to hernia repair.
Compared with the prior art, the invention has the beneficial effects that: (1) the polypropylene/tea polyphenol patch for intraperitoneal repair prepared by the invention contains a layer of poly tea polyphenol membrane, tea polyphenol is used as a green plant extract, the price is low, the biological safety is good, the property is stable, the good hydrophilicity and biocompatibility are realized, the poly tea polyphenol patch is stably attached and coated on the surface of a polypropylene material through a complex physical and chemical effect to form a layer of polymeric nano membrane, so that the polypropylene material is not directly contacted with abdominal organs, and complications such as intestinal adhesion and the like caused by the fact that the polypropylene is contacted with the abdominal organs are reduced; the polypropylene has good tensile strength, chemical substance erosion resistance and light foreign body sensation, and can promote the growth of fibroblasts in the body;
(2) the polypropylene/tea polyphenol patch prepared by the invention still keeps a certain mesh structure, is beneficial to tissue ingrowth and free access of macrophages and leucocytes, has better tissue strength, tensile strength and infection resistance, and meanwhile, the tea polyphenol also has antibacterial property and can better prevent and treat the in vivo infection problem of the implant material;
(3) the preparation method provided by the invention is simple in process, low in cost and stable in property.
Drawings
FIG. 1 is a graph of the experiment of example 1 at day 10 after the polypropylene/tea polyphenol patch for intraperitoneal repair was implanted into the abdominal cavity of a rat.
Detailed Description
The drawings are only for purposes of illustration and are not to be construed as limiting the invention. For a better understanding of the following embodiments, certain features of the drawings may be omitted, enlarged or reduced, and do not represent the size of an actual product; it will be understood by those skilled in the art that certain well-known structures in the drawings and descriptions thereof may be omitted.
Example 1
A polypropylene/tea polyphenol patch for intraperitoneal repair is prepared by the following steps:
step (1): preparing 50mL of N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution with the concentration of 100mmol/L, and adding 0.05g of tea polyphenol to ensure that the final concentration of the tea polyphenol is 1 g/L;
step (2): after the tea polyphenol is completely dissolved, adding a polypropylene mesh with the size of 3 multiplied by 3cm, immediately stirring and reacting at the temperature of 28 ℃, wherein the rotating speed is 400rpm, and reacting for 48 hours;
and (3): and taking out the polypropylene mesh, soaking the polypropylene mesh in deionized water for 10min, washing the polypropylene mesh and absolute ethyl alcohol respectively for 3 times, and drying the polypropylene mesh and the absolute ethyl alcohol in nitrogen to obtain the white polypropylene/tea polyphenol patch.
Example 2
A polypropylene/tea polyphenol patch for intraperitoneal repair is prepared by the following steps:
step (1): preparing 50mL of N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution with the concentration of 100mmol/L, and adding 0.2g of tea polyphenol to ensure that the final concentration of the tea polyphenol is 4 g/L;
step (2): after the tea polyphenol is completely dissolved, adding a 2 x 3cm polypropylene mesh, and immediately carrying out stirring reaction at 28 ℃ at the rotating speed of 400rpm for 48 hours;
and (3): and taking out the polypropylene mesh, soaking the polypropylene mesh in deionized water for 10min, washing the polypropylene mesh and the deionized water and absolute ethyl alcohol respectively for 3 times, and drying the polypropylene mesh and the absolute ethyl alcohol in nitrogen to obtain the white polypropylene/tea polyphenol patch.
Example 3
A polypropylene/tea polyphenol patch for intraperitoneal repair is prepared by the following steps:
step (1): preparing 50mL of N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution with the concentration of 100mmol/L, and adding 0.25g of tea polyphenol to ensure that the final concentration of the tea polyphenol is 5 g/L;
step (2): after the tea polyphenol is completely dissolved, adding a 2 x 2cm polypropylene mesh, and immediately carrying out stirring reaction at 28 ℃ at the rotating speed of 400rpm for 48 hours;
and (3): and taking out the polypropylene mesh, soaking the polypropylene mesh in deionized water for 10min, washing the polypropylene mesh and the deionized water and absolute ethyl alcohol respectively for 3 times, and drying the polypropylene mesh and the absolute ethyl alcohol in nitrogen to obtain the white polypropylene/tea polyphenol patch.
Animal examples
3 female SD rats weighing about 250g-300g are anesthetized by intraperitoneal injection with 1% sodium pentobarbital, the dosage is 50ml/kg, and the anesthesia induction time is 8 min. The abdomen of the rat was then exposed and a 6X 6cm hairless area was cleared in the center of the abdomen with scissors. A conventional sterile drape was used to make two approximately 3.5cm long skin incisions in the rat flank, 4cm apart, parallel to the longitudinal axis of the rat trunk, with a scalpel, and then the layers of the abdominal muscles were separated and incised layer by layer along the incisions into the abdominal cavity.
The polypropylene/tea polyphenol patch prepared in example 1-3 was sterilized with ethylene oxide, gently placed in the abdominal cavity, four corners of the patch were sutured and fixed to the inside of the abdominal wall with absorbable sutures, and the abdominal cavity was closed layer by layer. Then, the mental and dietary conditions of the rats are observed, the abdominal cavity is opened after 10 days, and the patches are observed for the existence and severity of adhesion.
Through experimental observation, after 10 days, the abdominal cavities of 3 rats are opened, no infection, no cladding effusion and pus accumulation are observed in the abdominal cavities, no obvious adhesion is observed in the patch, the filiform mesenteric adhesion is observed on the edge of part of the patch, no adhesion of abdominal cavity organs such as small intestine and the like is observed, one surface of the patch contacting the abdominal cavity organs is basically abdominated, and fig. 1 is an experimental diagram of the 10 th day after the polypropylene/tea polyphenol patch for intraperitoneal repair in example 1 is implanted in the abdominal cavity of the rat.
It should be understood that the above-mentioned embodiments of the present invention are only examples for clearly illustrating the technical solutions of the present invention, and are not intended to limit the specific embodiments of the present invention. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention claims should be included in the protection scope of the present invention claims.
Claims (6)
1. A preparation method of a polypropylene/tea polyphenol patch for intraperitoneal repair is characterized by comprising the following steps:
step (1): preparing 50-200mmol/L N, N-dihydroxyethyl glycine-sodium hydroxide buffer solution, adding tea polyphenol, and adjusting the dosage to obtain tea polyphenol with the solubility of 1.0-4.0 mg/mL;
step (2): after the tea polyphenol is completely dissolved, adding a polypropylene mesh into the solution, and stirring and reacting for 12-72 hours at the temperature of 10-40 ℃ in the air atmosphere;
and (3): taking out the polypropylene mesh, soaking in deionized water for 5-20min, washing with deionized water and anhydrous ethanol for 2-5 times, respectively, drying with inert gas to obtain polypropylene/tea polyphenol patch, and sealing in dark.
2. The method of preparing an intraperitoneal patch of polypropylene/tea polyphenol according to claim 1, wherein the concentration of said N, N-dihydroxyethylglycine-sodium hydroxide buffer solution is 100 mmol/L.
3. The method for preparing a polypropylene/tea polyphenol patch for intraperitoneal repair according to claim 1, wherein the step (2) is: after the tea polyphenol is completely dissolved, adding a polypropylene mesh into the solution, stirring and reacting at 25-30 ℃ in the air atmosphere at the rotation speed of 100-1000rpm for 30-50 h.
4. The method of preparing a polypropylene/tea polyphenol patch for intraperitoneal repair according to claim 1, wherein the mesh diameter of the polypropylene mesh is 0.1mm-1 cm.
5. An intraperitoneal patch of polypropylene/tea polyphenol for use in repair, prepared by a method according to any one of claims 1 to 4.
6. Use of an intraperitoneal patch of polypropylene/tea polyphenol for repair according to claim 5 in a repair material.
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| CN107237134A (en) * | 2017-07-14 | 2017-10-10 | 天津工业大学 | A kind of supper-fast hydrophilic preparation method of modified polypropene non-woven fabrics of polyphenol |
| CN107312139A (en) * | 2017-08-23 | 2017-11-03 | 四川大学 | The preparation method and application of anti-oxidant poly- tea polyphenol nano material |
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| WO2011147409A2 (en) * | 2010-05-27 | 2011-12-01 | Hemoteq Ag | Coating of endoprostheses with a coating consisting of a tight mesh of polymer fibres |
| KR101257996B1 (en) * | 2010-11-01 | 2013-04-30 | 아주대학교산학협력단 | Immobilization method of bioactive molecules using polyphenoloxidase |
| CN103191459B (en) * | 2013-04-06 | 2014-08-06 | 广东泰宝医疗科技股份有限公司 | Composite silica gel protective dressing and preparation method thereof |
| CN204542981U (en) * | 2015-04-13 | 2015-08-12 | 王辉 | For the material that abdominal-wall defect intraperitoneal is repaired |
| CN204745089U (en) * | 2015-05-07 | 2015-11-11 | 王辉 | A antiseized even polypropylene net piece material that what was used for damaged repair of stomach wall gathers dopamine peridium |
| CN104800889A (en) * | 2015-05-07 | 2015-07-29 | 王辉 | Preparation method of anti-adhesion polypropylene mesh coated with polydopamine for abdominal wall defect repair and obtained mesh material |
| KR101875291B1 (en) * | 2016-12-22 | 2018-07-05 | 김지수 | Functional patch attachable to brassiere |
| CN107158447B (en) * | 2017-07-06 | 2023-11-17 | 华南理工大学 | Antibacterial zein dressing with controllable orientation and preparation method thereof |
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| CN107237134A (en) * | 2017-07-14 | 2017-10-10 | 天津工业大学 | A kind of supper-fast hydrophilic preparation method of modified polypropene non-woven fabrics of polyphenol |
| CN107312139A (en) * | 2017-08-23 | 2017-11-03 | 四川大学 | The preparation method and application of anti-oxidant poly- tea polyphenol nano material |
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