CN102526567B - Ointment and medicine composite formula for removing tinea unguium and preparation method thereof - Google Patents
Ointment and medicine composite formula for removing tinea unguium and preparation method thereof Download PDFInfo
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- CN102526567B CN102526567B CN201110437785.5A CN201110437785A CN102526567B CN 102526567 B CN102526567 B CN 102526567B CN 201110437785 A CN201110437785 A CN 201110437785A CN 102526567 B CN102526567 B CN 102526567B
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Abstract
The invention relates to an ointment and medicine composite formula for removing tinea unguium and a preparation method thereof. The ointment comprises 3-5% of lithargyrum, 1-2% of calomel, 8-12% of potassium iodide, 3-6% of amorolfine, 25-35% of vaseline, 8-12% of lanolin, 25-35% of allantoin, and the balance of zinc oxide and white wax which account for 50% respectively. The medicine comprises 15-25% of radix stemonae, 15-25% of radix sophorae flavescentis, 15-25% of pseudolarix, 15-25% of balsam, 5-10% of borneol and the balance of vinegar. The preparation method comprises the following steps of: (1) mixing and stirring the accessories of the ointment, and heating to obtain ointment; and (2) grinding the accessories of the medicine into powder, and mixing the powder with the vinegar to obtain the medicine. The ointment is smeared to soften the nails with tinea unguium, and the medicine is applied to kill fungi and promote the growth of new nails. Through the invention, the cure rate is high, and the reoccurrence of tinea unguium can be effectively suppressed; and the ointment and medicine provided by the invention are safe without side effect and have an obvious curative effect and a short treatment period.
Description
Technical field
The present invention relates to remove the medicament of tinea unguium, especially a kind of for removing the ointment of tinea unguium and medicament combination preparation and preparation method thereof.
Background technology
Chinese patent CN1319563C, a kind of topical agent for the treatment of tinea unguium is disclosed, by A cream, B cream and medicinal liquid three parts, formed, main component is comprised of Flos Impatientis, Oleum Ocimi Gratissimi, Cortex Dictamni etc., have the effect of bactericidal antiphlogistic, disinfectant antipruritic, this invention is used for the treatment of in the process of tinea unguium, first with A cream, removes disease first, with medicinal liquid sterilization, then with B cream, promote new first growth again.
Chinese patent CN101693040B, discloses a kind of medicament for the treatment of tinea unguium and preparation method thereof, and this medicament comprises for removing the ointment of disease first and for killing fungus and expedite the emergence of the medicinal liquid of new first.The composition of ointment and weight proportion: carbamide 300-600 part, boric acid 100-200 part, salicylic acid 200-400 part, benzoic acid 100-200 part, phenol 60-100 part, 800 parts, cocaine hydrochloride 10-15 part and vaseline.The composition of medicinal liquid and weight proportion: Cortex Pseudolaricis 3-8 part, Fructus Cnidii 3-8 part, Radix Sophorae Flavescentis 3-8 part, Semen Hydnocarpi 3-8 part, salicylic acid 5-15 part, benzoic acid 5-15 part, glacial acetic acid 20-30 part, Mylabris 2-4 part, 85 parts of Camphora 2-4 part and 75% ethanol.This invention is first removed disease first by smearing ointment, then by smearing medicinal liquid killing fungus and expediting the emergence of new first.
The effect that above two disclosed medicaments of patent are used for the treatment of tinea unguium is unsatisfactory, some poison of drug side effect are larger, easily cause the untoward reaction such as skin allergy, some medicine therapeutic processes are long, drug effect is unbalanced, and effect can not be lasting, and the composition of medication is too complicated, cost is higher, has increased patient's treatment cost.
Summary of the invention
For above existing for removing the deficiency of the medicament of tinea unguium, the object of this invention is to provide a kind of evident in efficacy, have no side effect, treatment cycle is shorter for removing ointment and the medicament combination preparation of tinea unguium, and the preparation method of this ointment and medicament combination preparation.
The object of the invention is by realizing by the following technical solutions:
For removing ointment and the medicament combination preparation of tinea unguium, comprise ointment and medicament, wherein ointment is for softening tinea unguium, so that remove tinea unguium and promote the growth of new fingernail, described medicament is used for killing fungus and promotes the growth of new fingernail, and composition and the weight proportion of described ointment are as follows:
Potassium iodide 8-12%, Amorolfine 3-6%, vaseline 25-35%, lanoline 8-12%, allantoin 25-35%, surplus is additive;
Composition and the weight proportion of described medicament are as follows:
Radix Stemonae 15-25%, Radix Sophorae Flavescentis 15-25%, Cortex Pseudolaricis 15-25%, Flos Impatientis 15-25%, Borneolum Syntheticum 5-10%, surplus is vinegar.
As the preferred technical solution of the present invention, described ointment also comprises once 3-5% of close stone roller, Calomelas 1-2%; Described additive comprises that weight portion respectively accounts for half zinc oxide and white beeswax.
As the preferred technical solution of the present invention, composition and the weight proportion of described ointment are: close stone roller once 4%, Calomelas 1%, potassium iodide 10%, Amorolfine 5%, vaseline 30%, lanoline 10%, allantoin 30%, zinc oxide 5%, white beeswax 5%.
As the preferred technical solution of the present invention, composition and the weight proportion of described medicament are: the Radix Stemonae 20%, and Radix Sophorae Flavescentis 20%, Cortex Pseudolaricis 20%, Flos Impatientis 20%, Borneolum Syntheticum 5%, surplus is vinegar.
As the preferred technical solution of the present invention, described vinegar is that concentration is the acetum of 5-10%.
As the preferred technical solution of the present invention, described vinegar is that concentration is 6% acetum.
For removing the preparation method of ointment and the medicament of tinea unguium, comprise the following steps:
(1) by the close stone roller preparing by weight once, Calomelas, potassium iodide, Amorolfine, vaseline, lanoline and white beeswax puts into container mix and blend, container heated simultaneously, makes white beeswax melting;
(2) allantoin preparing by weight and zinc oxide are added in said mixture, and fully stirring makes it form body of paste, makes ointment;
(3) by the Radix Stemonae preparing by weight, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Flos Impatientis and Borneolum Syntheticum pulverize, then fully mix and make medicament with vinegar.
As the preferred technical solution of the present invention, the container of described step (1) comprises stainless-steel pan or ceramic pot.
As the preferred technical solution of the present invention, the heating-up temperature of described step (1) is no more than 90 ℃, and is incubated 5 to 10 minutes.
As the preferred technical solution of the present invention, the medicament that described step (3) makes after mixing also needs through sealing brewed 1 to 2 months.
The invention has the beneficial effects as follows: with respect to prior art, the present invention is first by smearing ointment for softening tinea unguium, so that remove tinea unguium and promote the growth of new fingernail, then by medicament killing fungus and promote the growth of new fingernail.Cure rate of the present invention is high, and can effectively contain to there is the recurrence of tinea unguium safety, no pain, have no side effect, be that a kind of drug effect is balanced, lasting, treatment cost is low, have no side effect, the medicine for external use for the treatment of tinea unguium evident in efficacy, treatment cycle is shorter.
The specific embodiment
Embodiment mono-
For removing ointment and the medicament combination preparation of tinea unguium, comprise ointment and medicament, wherein ointment is for softening tinea unguium, so that remove tinea unguium and promote the growth of new fingernail, described medicament is for killing fungus and promote the growth of new fingernail, composition and the weight proportion of described ointment are as follows: potassium iodide 8%, Amorolfine 3%, vaseline 30%, lanoline 12%, allantoin 35%, surplus is additive.Described in the present embodiment, additive comprises that weight portion respectively accounts for half zinc oxide and white beeswax.
In the present embodiment, composition and the weight proportion of described medicament are as follows: the Radix Stemonae 15%, and Radix Sophorae Flavescentis 15%, Cortex Pseudolaricis 25%, Flos Impatientis 25%, Borneolum Syntheticum 5%, surplus is that concentration is 5% acetum.
For removing the preparation method of ointment and the medicament of tinea unguium, comprise the following steps:
(1) potassium iodide preparing by weight, Amorolfine, vaseline, lanoline and white beeswax are put into container mix and blend, container is heated simultaneously, make white beeswax melting;
(2) allantoin preparing by weight and zinc oxide are added in said mixture, and fully stirring makes it form body of paste, makes ointment;
(3) by the Radix Stemonae preparing by weight, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Flos Impatientis and Borneolum Syntheticum pulverize, then fully mix and make medicament with vinegar.
In the present embodiment, the container of described step (1) comprises stainless-steel pan or ceramic pot, and heating-up temperature is no more than 90 ℃, and is incubated 5 to 10 minutes.The medicament that described step (3) makes after mixing need to be through sealing brewed 1 to 2 months.
Embodiment bis-
For removing ointment and the medicament combination preparation of tinea unguium, comprise ointment and medicament, composition and the weight proportion of described ointment are as follows: potassium iodide 12%, Amorolfine 6%, vaseline 35%, lanoline 8%, allantoin 25, surplus is additive.Described in the present embodiment, additive comprises that weight portion respectively accounts for half zinc oxide and white beeswax.
Composition and the weight proportion of described medicament are as follows: the Radix Stemonae 25%, and Radix Sophorae Flavescentis 25%, Cortex Pseudolaricis 15%, Flos Impatientis 15%, Borneolum Syntheticum 10%, surplus is that concentration is 10% acetum.The preparation method of described ointment and medicament is identical with embodiment mono-.
Embodiment tri-
For removing ointment and the medicament combination preparation of tinea unguium, comprise ointment and medicament, composition and the weight proportion of described ointment are as follows: close stone roller once 4%, Calomelas 1%, potassium iodide 10%, Amorolfine 5%, vaseline 30%, lanoline 10%, allantoin 30%, zinc oxide 5%, white beeswax 5%.
Composition and the weight proportion of described medicament are: the Radix Stemonae 20%, and Radix Sophorae Flavescentis 20%, Cortex Pseudolaricis 20%, Flos Impatientis 20%, Borneolum Syntheticum 5%, surplus is that concentration is 6% acetum.
For removing the preparation method of ointment and the medicament of tinea unguium, comprise the following steps:
(1) by the close stone roller preparing by weight once, Calomelas, potassium iodide, Amorolfine, vaseline, lanoline and white beeswax puts into container mix and blend, container heated simultaneously, makes white beeswax melting;
(2) allantoin preparing by weight and zinc oxide are added in said mixture, and fully stirring makes it form body of paste, makes ointment;
(3) by the Radix Stemonae preparing by weight, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Flos Impatientis and Borneolum Syntheticum pulverize, then fully mix and make medicament with vinegar.
In the present embodiment, the container of described step (1) comprises stainless-steel pan or ceramic pot, and heating-up temperature is no more than 90 ℃, and is incubated 5 to 10 minutes.The medicament that described step (3) makes after mixing need to be through sealing brewed 1 to 2 months.
When the present invention uses, can soften tinea unguium, promote horny layer to transform, removing the necrotic tissue and promoting granulation, is conducive to remove tinea unguium, and energy killing fungus, promotes the growth of new fingernail.Below for two examples: people from Jiangyan City of Mrs Qian ，56Sui， Jiangsu Province, 10 toes are suffered from tinea unguium, after adopting the combination preparation treatment of ointment of the present invention and medicament, recovery from illness in three months.People from Jiangyan City of Mr. Wang ，42Sui， Jiangsu Province, 4 fingers are suffered from tinea unguium, after adopting the combination preparation treatment of ointment of the present invention and medicament, recovery from illness in two months.
Claims (1)
1. for removing a preparation method for ointment and the medicament combination preparation of tinea unguium, it is characterized in that said method comprising the steps of:
Composition and the weight proportion of described ointment are as follows: close stone roller once 4%, Calomelas 1%, potassium iodide 10%, Amorolfine 5%, vaseline 30%, lanoline 10%, allantoin 30%, zinc oxide 5%, white beeswax 5%;
Composition and the weight proportion of described medicament are as follows: the Radix Stemonae 20%, and Radix Sophorae Flavescentis 20%, Cortex Pseudolaricis 20%, Flos Impatientis 20%, Borneolum Syntheticum 5%, surplus is vinegar, described vinegar is that concentration is 6% acetum;
(1) by the close stone roller preparing by weight once, Calomelas, potassium iodide, Amorolfine, vaseline, lanoline and white beeswax puts into container mix and blend, container heated simultaneously, makes white beeswax melting;
(2) allantoin preparing by weight and zinc oxide are added in said mixture, and fully stirring makes it form body of paste, makes ointment;
(3) by the Radix Stemonae preparing by weight, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Flos Impatientis and Borneolum Syntheticum pulverize, then fully mix and make medicament with vinegar;
The container of described step (1) comprises stainless-steel pan or ceramic pot; The heating-up temperature of described step (1) is no more than 90 ℃, and is incubated 5 to 10 minutes; The medicament that described step (3) makes after mixing also needs through sealing brewed 1 to 2 months.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110437785.5A CN102526567B (en) | 2011-12-23 | 2011-12-23 | Ointment and medicine composite formula for removing tinea unguium and preparation method thereof |
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| CN201110437785.5A CN102526567B (en) | 2011-12-23 | 2011-12-23 | Ointment and medicine composite formula for removing tinea unguium and preparation method thereof |
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| CN102526567A CN102526567A (en) | 2012-07-04 |
| CN102526567B true CN102526567B (en) | 2014-01-22 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103819941A (en) * | 2014-02-12 | 2014-05-28 | 铜陵瑞莱科技有限公司 | Iron oxide red pigment containing balsamine pollen |
| CN105878515A (en) * | 2016-05-27 | 2016-08-24 | 廖鲜芳 | Matching agent for treating onychomycosis |
| CN110833584A (en) * | 2018-08-16 | 2020-02-25 | 安徽世龙生物医药科技有限公司 | Impatiens balsamina antibacterial liquid and preparation method thereof |
| CN109820973A (en) * | 2019-03-07 | 2019-05-31 | 江西鼎中科技有限公司 | A kind of nano-calcium carbonate magnesium ointment for treating onychomycosis |
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| CN1070108A (en) * | 1991-09-03 | 1993-03-24 | 蒋明 | The prescription and the compound method thereof of finger, toenail ringworm paste |
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Address after: 541002 No. two, No. 5, West Road, Xiangshan District, Guilin, the Guangxi Zhuang Autonomous Region Patentee after: Cheng Meiyu Address before: 225500, room 71, building 305, Zhongtian village, Jiangyan Town, Jiangyan City, Jiangsu, Taizhou Patentee before: Cheng Meiyu |
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Address after: 225500, room 71, building 305, Zhongtian village, Jiangyan Town, Jiangyan City, Jiangsu, Taizhou Patentee after: Cheng Meiyu Address before: 541002 No. two, No. 5, West Road, Xiangshan District, Guilin, the Guangxi Zhuang Autonomous Region Patentee before: Cheng Meiyu |
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