CN106983784A - A kind of scar eliminating silicone gel and preparation method thereof - Google Patents
A kind of scar eliminating silicone gel and preparation method thereof Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/30—Zinc; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Abstract
The present invention relates to biomedicine technical field, and in particular to a kind of scar eliminating silicone gel and preparation method thereof.The silicone gel is made up of following raw material：1 ~ 10 part of dimethicone, 10 ~ 30 parts of HMDO, 20 ~ 60 parts of dimethyl silicone polymer self-crosslinking polymer, 0 ~ 10 part of natural plants antiseptic, 0 ~ 5 part of antipruritic.In the presence of HMDO, dimethicone and dimethyl silicone polymer self-crosslinking polymer quickly can be crosslinked with other components to be combined, and HMDO has strong volatility, each material crosslinking can be quickly promoted to form thin film after combining, it is brought into close contact well with epidermis, ensure the aquation of skin, with the effect for smoothing and softening scar caused by various external causes, while each composition Synergistic, it is significant to improve scar pigmentation, improve the symptoms such as scar itch, erythema.
Description
Technical field
The present invention relates to biomedicine technical field, and in particular to a kind of scar eliminating silicone gel and preparation method thereof.
Background technology
Scar is that histology regeneration can not be fully achieved after body is damaged and repairing for progress is substituted with connective tissue,
A kind of compensatory incomplete regen-eration, its essence be it is a kind of do not possess regular skin structure and function, exception, unsound group
Knit.Burn, scald, surgical operation etc. are the main causes for causing skin histology hyperplastic scar, while collagenic supersession is unbalance, flesh
The factors such as fibroblastic contraction, the change of dermal extracellular matrix composition can also produce hyperplastic scar.
Silica hydrogel is the line product that global medical expert recommends treatment scar, can create preferable environment for scar.
In addition, silicone gel has the small feature of permeability to hydrone, it can play and be acted on epithelium cuticula identical, promote to burn
Scar recovers the stability of interior environment after wound, mitigates capillary injection and fibroplasia, so as to prevent the shape of hyperplastic scar
Into.But, existing Silica hydrogel product is more greasy, is difficult to absorb after smearing, for scar pigmentation, improve scar itch,
It is often unsatisfactory on the effects such as erythema.
The content of the invention
In order to overcome the defect of prior art, it is an object of the invention to provide a kind of scar eliminating silicone gel, with quick
It can be combined closely after film forming, smearing with epidermis, can significantly improve scar pigmentation, improve scar itch and red
Spot, evident in efficacy, short treating period.
Meanwhile, the present invention, which is also resided in, provides a kind of preparation method of scar eliminating silicone gel.
In order to realize the above object the technical solution adopted in the present invention is：
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：1 ~ 10 part of dimethicone, hexamethyl two
10 ~ 30 parts of siloxanes, 20 ~ 60 parts of dimethyl silicone polymer self-crosslinking polymer, 0 ~ 10 part of natural plants antiseptic, antipruritic 0 ~
5 parts.
The viscosity of above-mentioned scar eliminating silicone gel is 10 ~ 20Pa.s.
Optionally, the natural plants antiseptic be 2 ~ 5 parts of moutan bark extract solution, 3 ~ 4 parts of aloe-emodin, matrine 2 ~
5 parts, wherein moutan bark extract solution, aloe-emodin and matrine is oiliness extract.
Optionally, the antipruritic is calamine；Its parts by weight consumption is 2 ~ 5 parts.
Optionally, the molecular weight of the dimethyl silicone polymer self-crosslinking polymer is 8000 ~ 20000.
Optionally, the viscosity of the HMDO is 10cst ~ 50cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and antipruritic are added
Agent, stirs, filling, that is, completes.
Scar eliminating silicone gel of the present invention, with dimethicone, HMDO, dimethyl silicone polymer self-crosslinking
Polymer is prepared from for silicone composition, further to use moutan bark extract solution, aloe-emodin, matrine compound as anti-
Bacterium composition, using calamine as antipruritic composition, wherein in the presence of HMDO, dimethicone and poly- diformazan
Radical siloxane self-crosslinking polymer can quickly be crosslinked with the active ingredient in antimicrobial component and antipruritic composition and combine, and six
Tetramethyldisiloxane has strong volatility, can quickly promote each material crosslinking to form thin film after combining, well
It is brought into close contact with epidermis, it is ensured that the aquation of skin, tool smooths and softens scar caused by various external causes, while moutan bark is carried
Take liquid, aloe-emodin, matrine poly- in dimethicone and dimethyl silicone polymer self-crosslinking as the anti-scar composition of antibacterial
Under the promotion of compound, synergistic function is played with antipruritic calamine, it is significant to improve scar pigmentation, improve scar scabies
Itch, the symptom such as erythema, can significantly treat various hyperplastic scars.
The preparation method of scar eliminating silicone gel of the present invention, it is easy to operate, it is easy to control, suitable for industrial application.
Embodiment
Technical scheme is described in detail below by specific embodiment.
The viscosity of the scar eliminating silicone gel prepared in following embodiments and comparative example is 10 ~ 20Pa.s.
Embodiment 1
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：5 parts of dimethicone, the silicon of hexamethyl two
10 parts of oxygen alkane, 60 parts of dimethyl silicone polymer self-crosslinking polymer, 2 parts of moutan bark extract solution, 3 parts of aloe-emodin, matrine 2
Part, 3 parts of calamine；Wherein moutan bark extract solution, aloe-emodin and matrine are oiliness extract；Dimethyl silicone polymer
The molecular weight of self-crosslinking polymer is 8000；The viscosity of HMDO is 15cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and stove are added sweet
Stone, stirs, filling in medical aluminum-plastic packaged pipe, that is, completes.
Embodiment 2
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：1 part of dimethicone, the silicon of hexamethyl two
30 parts of oxygen alkane, 20 parts of dimethyl silicone polymer self-crosslinking polymer, 2 parts of moutan bark extract solution, 4 parts of aloe-emodin, matrine 3
Part, 5 parts of calamine；Wherein moutan bark extract solution, aloe-emodin and matrine are oiliness extract；Dimethyl silicone polymer
The molecular weight of self-crosslinking polymer is 10000；The viscosity of HMDO is 50cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and stove are added sweet
Stone, stirs, filling in medical aluminum-plastic packaged pipe, that is, completes.
Embodiment 3
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：10 parts of dimethicone, the silicon of hexamethyl two
15 parts of oxygen alkane, 45 parts of dimethyl silicone polymer self-crosslinking polymer, 5 parts of moutan bark extract solution, 3 parts of aloe-emodin, matrine 2
Part, 2 parts of calamine；Wherein moutan bark extract solution, aloe-emodin and matrine are oiliness extract；Dimethyl silicone polymer
The molecular weight of self-crosslinking polymer is 20000；The viscosity of HMDO is 10cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and stove are added sweet
Stone, stirs, filling in plastic tube, that is, completes.
Embodiment 4
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：10 parts of dimethicone, the silicon of hexamethyl two
15 parts of oxygen alkane, 45 parts of dimethyl silicone polymer self-crosslinking polymer；The molecular weight of dimethyl silicone polymer self-crosslinking polymer is
20000；The viscosity of HMDO is 10cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
It is filling in plastic tube after dimethyl silicone polymer self-crosslinking polymer is well mixed, that is, complete.
Embodiment 5
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：8 parts of dimethicone, the silicon of hexamethyl two
20 parts of oxygen alkane, 40 parts of dimethyl silicone polymer self-crosslinking polymer, 2 parts of moutan bark extract solution, 3 parts of aloe-emodin, matrine 5
Part, 4 parts of calamine；Wherein moutan bark extract solution, aloe-emodin and matrine are oiliness extract；Dimethyl silicone polymer
The molecular weight of self-crosslinking polymer is 20000；The viscosity of HMDO is 10cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and stove are added sweet
Stone, stirs, filling in plastic tube, that is, completes.
Embodiment 6
A kind of scar eliminating silicone gel, is prepared from by the raw material of following parts by weight：7 parts of dimethicone, the silicon of hexamethyl two
25 parts of oxygen alkane, 38 parts of dimethyl silicone polymer self-crosslinking polymer, 3 parts of moutan bark extract solution, 3.5 parts of aloe-emodin, kuh-seng
3 parts of alkali, 3 parts of calamine；Wherein moutan bark extract solution, aloe-emodin and matrine are oiliness extract；Poly dimethyl silicon
The molecular weight of oxygen alkane self-crosslinking polymer is 20000；The viscosity of HMDO is 10cst.
The preparation method of above-mentioned scar eliminating silicone gel, including take by weight dimethicone, HMDO,
After dimethyl silicone polymer self-crosslinking polymer is well mixed, moutan bark extract solution, aloe-emodin, matrine and stove are added sweet
Stone, stirs, filling in plastic tube, that is, completes.
Comparative example 1
This comparative example scar eliminating silicone gel, as different from Example 3, is prepared from by the raw material of following parts by weight：Six
15 parts of tetramethyldisiloxane, 55 parts of dimethyl silicone polymer self-crosslinking polymer, 5 parts of moutan bark extract solution, aloe-emodin 3
Part, 2 parts of matrine, 2 parts of calamine.Other be the same as Examples 3.
Comparative example 2
This comparative example scar eliminating silicone gel, as different from Example 3, is prepared from by the raw material of following parts by weight：Two
10 parts of methyl-silicone oil, 15 parts of HMDO, 45 parts of dimethyl silicone polymer self-crosslinking polymer, moutan bark extract solution 10
Part, 2 parts of calamine.Other be the same as Examples 3.
Comparative example 3
This comparative example scar eliminating silicone gel, as different from Example 3, is prepared from by the raw material of following parts by weight：Two
10 parts of methyl-silicone oil, 15 parts of HMDO, 55 parts of dimethyl silicone polymer self-crosslinking polymer, moutan bark extract solution 7
Part, 3 parts of aloe-emodin, 2 parts of matrine.Other be the same as Examples 3.
Comparative example 4
This comparative example scar eliminating silicone gel, as different from Example 3, is prepared from by the raw material of following parts by weight：Two
10 parts of methyl-silicone oil, 15 parts of HMDO, 55 parts of dimethyl silicone polymer self-crosslinking polymer, 12 parts of calamine.Its
His be the same as Example 3.
Test example
Test method：Using animal hyperplastic scar model, embodiment 3, comparative example 1 ~ 4 are evaluated by clinical therapeutic efficacy and prepared
Silicone gel effect；
Build animal hyperplastic scar model：New Zealand's large ear rabbit 20 is chosen, 3~4 months rabbit ages, rabbit ear perfects, body weight
2.0~3.0Kg, artificial mixed fodder point cage is fed, and adaptability feeds 72h, and scar model, wound doctor are set up in rabbit ear veutro
Covered with polyurethane transparent dressing until healing.
Packet：20 New Zealand's large ear rabbits for having built scar model are randomly divided into A, B, C, D, E, 5 groups, every group 4
Only, the silicone gel that wherein A groups are prepared using embodiment 3；The silicone gel that B groups are prepared using comparative example 1；C groups are using contrast
Silicone gel prepared by example 2；The silicone gel that D groups are prepared using comparative example 3；The silicone gel that E groups are prepared using comparative example 4；
Every group of usage and dosage is：Smear sooner or later daily twice, it is continuous to smear 28 days.
As a result count：Pigment deposition situation is observed at each scar model scar after 28 days and to scar hyperplasia, erythema
Deng improvement situation analyzed；
Wherein it is for the analysis method that scar hyperplasia, erythema improve situation：Put to death within 28th day rabbit and cut scar sample, mark
Originally scar tissue center and periphery junctional area are derived from, with fixed in paraformaldehyde solution, is carried out through FFPE, HE, VG dyeing
Histological observation.
Result of the test shows that A groups scar is almost without macroscopic pigmentation, and scar tissue is flatter, into fiber finer
Born of the same parents are less, and cell space is smaller, and collagen is sparse, arrange relatively regular；
B group scars have macroscopic pigmentation, and scar tissue thickness is thickened substantially, and fibroblast is more and big, and collagen is fine
The fine and close thick, arrangement disorder of dimension；
Substantially, scar tissue slightly has to be thickened C group scars pigmentation, and fibroblast becomes many and cell space is larger, and collagen is thin
Fiber is finer and close, and arrangement is not regular enough；
Substantially, scar tissue thickness is thickened substantially D group scars pigmentation, and fibroblast is more and big, and collagenous fibres are fine and close thick
Greatly, arrangement disorder；
Substantially, scar tissue thickness is thickened substantially E group group scars pigmentation, and fibroblast is more and big, and collagenous fibres are fine and close
Thick, arrangement disorder；
Above-mentioned each group difference is statistically significant（P<0.01）.
Embodiment 3 compares comparative example 1, and comparative example 1 saves dimethicone, improves dimethione self-crosslinking polymer
Consumption, the above results show that embodiment 3 prevents the treatment of the generation of hyperplastic scar for preventing pigmentation at scar
Effect is substantially better than comparative example 1, it can be seen that dimethicone, dimethione self-crosslinking polymer are simultaneously in use, energy
It is enough to play synergistic function between moutan bark extract solution, aloe-emodin, matrine and antipruritic well, lift silicone
Gel prevents pigmentation at scar, prevents effect of cell tissue hyperplasia at scar, significantly can prevent wound from being formed
Obvious scar；
Embodiment 3 is compared in comparative example 2, comparative example 2 and saves aloe-emodin and matrine, is extracted using single moutan bark
Liquid；Embodiment 3 compares comparative example 3, and comparative example 3 eliminates antipruritic；Embodiment 3 compares comparative example 4, and comparative example 4 eliminates male
Root bark of tree peony extract solution, aloe-emodin and matrine, as a result show, embodiment 3 prevents hyperplasia for preventing pigmentation at scar
The therapeutic effect of the generation of scars is substantially better than comparative example 2, comparative example 3 and comparative example 4, it can be seen that, using aloe rheum officinale
Element, aloe-emodin and matrine are used in combination, then compound antipruritic, in dimethicone, HMDO and poly- two
In the presence of methylsiloxane self-crosslinking polymer, there is synergistic function each other, silicone can be obviously improved
Gel prevents pigmentation at scar, prevents effect of cell tissue hyperplasia at scar, significantly can prevent wound from being formed
Obvious scar.
Silicone gel prepared by above-described embodiment 1 ~ 2 and embodiment 5 ~ 6 is to preventing pigmentation at scar, preventing Hypertrophic
The effect of scar and embodiment 3 are substantially equivalent.Silicone gel prepared by embodiment 4 can be quickly one layer thin in scar surface formation
Film, fits well with superficial skin, and it is excessive to overcome traditional silicone gel oiliness on the market, smears inconvenient, it is impossible to quick
The defect of film forming.
Claims (6)
1. a kind of scar eliminating silicone gel, it is characterised in that be prepared from by the raw material of following parts by weight：Dimethicone 1 ~
10 parts, 10 ~ 30 parts of HMDO, 20 ~ 60 parts of dimethyl silicone polymer self-crosslinking polymer, natural plants antiseptic 0 ~
10 parts, 0 ~ 5 part of antipruritic.
2. scar eliminating silicone gel as claimed in claim 1, it is characterised in that the natural plants antiseptic carries for moutan bark
2 ~ 5 parts of liquid, 3 ~ 4 parts of aloe-emodin, 2 ~ 5 parts of matrine are taken, wherein moutan bark extract solution, aloe-emodin and matrine is
Oiliness extract.
3. scar eliminating silicone gel as claimed in claim 1, it is characterised in that the antipruritic is calamine；Its parts by weight
Number consumption is 2 ~ 5 parts.
4. scar eliminating silicone gel as claimed in claim 1, it is characterised in that the dimethyl silicone polymer self-crosslinking polymerization
The molecular weight of thing is 8000 ~ 20000.
5. scar eliminating silicone gel as claimed in claim 1, it is characterised in that the viscosity of the HMDO is
10cst~50cst。
6. a kind of preparation method of scar eliminating silicone gel as described in any one of claim 1 ~ 5, it is characterised in that including by
After parts by weight take dimethicone, HMDO, dimethyl silicone polymer self-crosslinking polymer well mixed, add male
Root bark of tree peony extract solution, aloe-emodin, matrine and antipruritic, stir, filling, that is, complete.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108403623A (en) * | 2018-05-29 | 2018-08-17 | 南京华开生物科技有限公司 | silicone scar gel |
| CN108714141A (en) * | 2018-05-29 | 2018-10-30 | 南京华开生物科技有限公司 | Silicone scar spray |
| CN109762100A (en) * | 2018-11-01 | 2019-05-17 | 扬州大学 | A kind of aloe-emodin/carbon nano-particle anti-bacterial hydrogel and preparation method thereof |
| CN109762100B (en) * | 2018-11-01 | 2021-05-14 | 扬州大学 | Aloe-emodin/carbon nano-particle antibacterial hydrogel and preparation method thereof |
| CN109908076A (en) * | 2019-03-25 | 2019-06-21 | 河南沃迈生物科技有限公司 | A kind of silicone gel |
| CN113318094A (en) * | 2021-05-08 | 2021-08-31 | 广州贝昊医疗科技有限公司 | Silicone gel patch containing plant herbal components and manufacturing method thereof |
| CN114668884A (en) * | 2022-03-31 | 2022-06-28 | 湖南有美生物科技有限公司 | Scar dressing containing traditional Chinese medicine exosomes and preparation method thereof |
| CN114699508A (en) * | 2022-04-12 | 2022-07-05 | 南京天朗制药有限公司 | Silicone gel and preparation method and application thereof |
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