CN104784066A - Ultraviolet-resistant silica gel composition - Google Patents
Ultraviolet-resistant silica gel composition Download PDFInfo
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- CN104784066A CN104784066A CN201510168588.6A CN201510168588A CN104784066A CN 104784066 A CN104784066 A CN 104784066A CN 201510168588 A CN201510168588 A CN 201510168588A CN 104784066 A CN104784066 A CN 104784066A
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- polydimethylsiloxane
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Abstract
Ultraviolet-resistant silica gel composition comprises cross-linked PDMS (polydimethylsiloxane), PDMS, annular siloxane, titanium dioxide nanoparticles and zinc oxide nanoparticles. The silica gel composition is formed by compounding the cross-linked PDMS, the PDMS, the volatile annular siloxane, the titanium dioxide particles and the zinc oxide nanoparticles. The titanium dioxide particles and the zinc oxide particles are well dispersed in the composition through control on particle sizes of the titanium dioxide particles and the zinc oxide particles as well as surface lipophilic modification, and scar treatment with silica gel and ultraviolet resistance of skin sunscreen products are realized through control on the concentration of the titanium dioxide particles and the zinc oxide particles.
Description
Technical field
The present invention relates to a kind of anti-ultraviolet Silica hydrogel compositions.
Background technology
Cicatrix is the mode of appearance of normal skin tissue caused after various wound and the general designation of tissue pathologies change, is generally divided into epigenetic-surface reworking, hypertrophic cicatrix, atrophic scar and keloid.The pathological tissue difference of hypertrophic cicatrix and abnormal scar is thickening of cicatrix deep collagen fiber.Hypertrophy cicatrix shows as protuberate, and profile is irregular, is uneven, and flushing is congested, and matter is real tough.Keloid is the result of collagen fiber hyperplasia in skin injury agglutination, shows as and exceeds normal skin, and shape differs, the benign tumors that the red matter of color is hard.Cicatrix growth exceedes certain limit, various complication can occur, the destruction of such as profile and functional activity obstacle etc., brings huge human body misery and psychic pain to patient.
Research shows, certain humidity and ventilative environment can reduce undue growth [the Quinn K. J. of scar tissue, Evans J.H., Courtney J. M., Gaylor J.D.S., Reid W.H. Non pressure treatment of hypertrophic scars. Burns.1985,12,102 – 108.].Silica hydrogel has good permeability, also has certain steam breathability, can keep the certain moist and ventilative environment of skin area.At present, Silica hydrogel has been widely used in hypertrophy cicatrix and keloidal treatment.Mainly Silica hydrogel cicatrix pad pasting [the Perkins K. of early application; Davey R.B.; Walis A. Silicone gel:A new treatment for burn scars and constracture. Burns. 1983,9 (3), 201; Sun Ping Wei, Liu Chang, Tai rather just, thank to Jiangning, Sun Hui, Shen Jun, Xia Chenglin, yellow Aiwa.Silica hydrogel cicatrix pad pasting prevents and treats the clinical research of hypertrophic cicatrix after wound.Zhenjiang medical college journal, 2000,10 (2), 324-326.]。Silica hydrogel pad pasting can be affixed in affected part, naturally bonds, but joint part or not easily paste smooth place and need to bandage and make it close contact.Attractive in appearance owing to affecting, patient neither feel quite pleased for using Silica hydrogel pad pasting at visible damage position.Silica hydrogel pad pasting to use continuously and to need to reach 12 hours every day, to a certain degree limits movable and work on daytime.
Newer product can apply or be sprayed at skin area and the rapid film forming Silica hydrogel of energy at present.This series products can be convenient to use in any position, solves Silica hydrogel pad pasting at joint part or not easily paste smooth place and contact bad problem.And this Silica hydrogel forms very thin one deck on skin, motion and work can not be affected, also can not affect the attractive in appearance of visible damage position.In the market apply or be sprayed at skin area and can rapid film forming Silica hydrogel product based on the Dermatix of the international drugmaker of the Kelo-cote of United States advanced technology company and U.S. Wei Lang.Also there is the product such as DOW CORNING 1544 and DOW CORNING 1688 in Dow corning company.
Accept ultraviolet irradiation in appropriate amount and be of value to health, but excessively accepting ultraviolet radiation then can cause some dermatosis for a long time.By UVB(ultraviolet B radiation) excessive exposure can cause the acute sunburn of skin, and make skin produce erythema, occur irritated or phenomenon of burning.The penetration capacity of UVA (long wave ultraviolet) is stronger, can arrive skin corium and bring disaster to subcutaneous tissue, producing lasting, cumulative photo oxidative damage, can also cause skin photo-ageing to Skin Cell, the normal immune system of infringement skin.The energy force rate normal skin of cicatrix to uvioresistant (UV) radiation is more weak.Under especially new for scar scar is exposed to UV, because UV can increase melanin, thus it is black that scar position is added, thus affect therapeutic effect [Dan little Hong, Zhao Chunli.The preparation of organosilicon/composite titania material and anti-ultraviolet property analysis. Chinese Plastics 2012,26(9), 69-71.]。
Applying or being sprayed at skin area and can the main component of rapid film forming Silica hydrogel product be crosslinked polydimethylsiloxane, polydimethylsiloxane, aerosil particle, D5 etc. in the market.These products do not have anti-ultraviolet function.
Summary of the invention
The present invention provides a kind of anti-ultraviolet Silica hydrogel compositions technical problem to solve exactly.
For solving the problems of the technologies described above, the technical solution of a kind of anti-ultraviolet Silica hydrogel compositions of the present invention is:
Comprise crosslinked polydimethylsiloxane, polydimethylsiloxane, annular siloxane, also containing titanium dioxide nano-particle, zinc oxide nano-particle.
Described crosslinked polydimethylsiloxane accounts for by weight 15%45% of described compositions; Polydimethylsiloxane accounts for by weight 1%15% of described compositions; Annular siloxane accounts for by weight 30%70% of described compositions; Titanium dioxide nano-particle accounts for by weight 1%10% of described compositions; Zinc oxide nano-particle accounts for by weight 1%10% of described compositions.
As preferably, described annular siloxane is D5; Described five siloxanes account for by weight 40%60% of described compositions.
As preferably, described polydimethylsiloxane viscosity is between 10 cSt100000 cSt.
As preferably, described polydimethylsiloxane viscosity is between 1000 cSt30000 cSt.
As preferably, lipophile process has been carried out on described zinc oxide nano-particle surface, and particle diameter is between 10-60 nm.
As preferably, described titanium dioxide nano-particle accounts for by weight 1%5% of described compositions.
As preferably, described polydimethylsiloxane accounts for by weight 5%10% of described compositions.
As preferably, described crosslinked polydimethylsiloxane accounts for by weight 25%40% of described compositions.
The technique effect that the present invention can reach is: do not have anti-ultraviolet function in Silica hydrogel treating acne product in the market.Silica hydrogel provided by the invention is that polydimethylsiloxane, volatile cyclic silicones, TiO 2 particles, zinc oxide nano-particle is composited with crosslinked polydimethylsiloxane.By regulating and controlling the particle diameter of TiO 2 particles and zinc oxide particles, the surperficial lipophile of TiO 2 particles and zinc oxide particles is modified to reach fine dispersion in the product, the concentration of TiO 2 particles and zinc oxide particles, realizes the anti-ultraviolet property of Silica hydrogel treating acne and antitan agent product.
Below in conjunction with detailed description of the invention, the present invention is further detailed explanation.
Detailed description of the invention
Elaboration detailed is further done to the present invention below.
The object of this invention is to provide a kind of uvioresistant titanium dioxide nano-particle, zinc oxide nano-particle and Silica hydrogel compositions, for the treatment of cicatrix, thus avoid ultraviolet on the impact of the especially new scar site treatment effect of scar.Said composition also can be used for the sun-proof of skin.
Silica hydrogel provided by the invention is that polydimethylsiloxane, volatile cyclic silicones, TiO 2 particles, zinc oxide particles etc. are composited with crosslinked polydimethylsiloxane.
The crosslinked polydimethylsiloxane cross-linking agent that the present invention uses, polydimethylsiloxane, volatile cyclic silicones, TiO 2 particles etc. are commercial product.As crosslinked polydimethylsiloxane can be the DOW CORNING TI-3021 SILICONE ELASTOMER BLEND of Dow corning company.Polydimethylsiloxane can Dow corning company there is the DOW CORNING TI-1050 FLUID(10 of different viscosities, 30000,100000 cST).Crosslinked polydimethylsiloxane or the polydimethylsiloxane of high molecular weight is mixed with volatile cyclic silicones can have the spreadability, film property and the skinfeel that keep it.According to the research of Dow Corning company, volatility cyclotetrasiloxane (D4) and D5 (D5) are when absorbing through skin, D4 have be less than 0.5 wt% and D5 have be less than 0.1 wt% absorbed [Marina L. Jovanovic by mouse whole body system, Joan M. McMahon, Debra A. McNett, Joseph M. Tobin, Kathleen P. Plotzke.Regulatory Toxicology and Pharmacology 2008, 50, 239–248]。Preferably by the volatility D5 that skin less absorbs in the present invention, can be the XIAMETER PMX-0245 Cyclopentasiloxane of Dow corning company.TiO 2 particles can be the nanometer particle of different size, and on market, supplier is a lot.Preferred particle narrow size distribution, the titanium dioxide nano-particle of particle diameter between 10-60 nm.Zinc oxide particles can be the nanometer particle of different size, and on market, supplier is a lot.Preferred particle narrow size distribution, the zinc oxide nano-particle of particle diameter between 10-60 nm.By adjustment polydimethylsiloxane cross-linking agent, polydimethylsiloxane, volatile cyclic silicones, TiO 2 particles, the ratio of zinc oxide, can ensure obstruct steam performance, permeability, paintability and the anti-ultraviolet property of product simultaneously.
The ultraviolet screening ability of titanium dioxide nano-particle and zinc oxide nano-particle and its uniformity coefficient disperseed at application system have much relations, disperse better with identical and that quantity the is equal TiO 2 particles of distribution at application system for initial size, its shielding ultraviolet rays ability is stronger.The crosslinked polydimethylsiloxane cross-linking agent that the present invention uses, polydimethylsiloxane, volatile cyclic silicones etc. are non-polar high polymer or nonpolar micromolecular compound, therefore the present invention carries out surperficial lipophile process to titanium dioxide nano-particle and zinc oxide nano-particle surface, to realize titanium dioxide nano-particle and zinc oxide nano-particle fine dispersion in the base.In the present invention, titanium dioxide nano-particle and zinc oxide nano-particle surface treatment with organosiloxane process, organic aliphatic acid and Ficus caricaL, coupling agent treatment or polyhydric alcohol process etc., can preferably have organic siloxane process.
In Silica hydrogel treating acne product of the present invention after titanium dioxide nano-particle used and zinc oxide nano-particle, its product should have good sun-proof ability.In order to reach, there is higher SPF value, ensure the permeability and paintability etc. of product simultaneously, in the present invention, titanium dioxide nano-particle and zinc oxide nano-particle addition should be all 1 wt% ~ 10 wt% of product gross mass, are preferably all 1 wt% ~ 5 wt%.
In order to reach good sun-proof ability, permeability and paintability, as preferably, described crosslinked polydimethylsiloxane accounts for by weight 15%45% of described compositions; Polydimethylsiloxane accounts for by weight 1%15% of described compositions; Annular siloxane accounts for by weight 30%70% of described compositions;
As preferably, described annular siloxane is D5; Described five siloxanes account for by weight 40%60% of described compositions.
Lipophile process has been carried out on described zinc oxide nano-particle surface,
As preferably, described polydimethylsiloxane viscosity is between 10 cSt100000 cSt.
As preferably, described polydimethylsiloxane viscosity is between 1000 cSt30000 cSt.
As preferably, described polydimethylsiloxane accounts for by weight 5%10% of described compositions.
As preferably, described crosslinked polydimethylsiloxane accounts for by weight 25%40% of described compositions.
Titanium dioxide nano-particle in the present invention and zinc oxide nano-particle, except anti-ultraviolet property, can also improve the viscosity of Silica hydrogel product, improve Silica hydrogel to the attachment of skin area and the antifouling property improving Silica hydrogel.
Experimental technique in following embodiment, if no special instructions, is conventional method.
The polydimethylsiloxane (DOW CORNING TI-3021 SILICONE ELASTOMER BLEND) crosslinked by 35 wt%, 53 wt% D5s, 7 wt% polydimethylsiloxane (DOW CORNING TI-1050 FLUID, 30000 cST), 3 wt% oleophylic titanium dioxide nano-particle (Shanghai Jiang Lu Industrial Co., Ltd.s, nano titanium oxide, model 04, mean diameter 30 nm) and 2 wt% oleophylic zinc oxide nano-particle (Hangzhou Wanjing New Material Co., Ltd., nano zine oxide, mean diameter 50 nm) at room temperature stirring obtains compositions.
In embodiment 1, the paintability test comparison sample of compositions is Kelo-cote, and test position is the forearm position participating in tester.Found by contrast test, in embodiment 1, compositions can easily apply, and in embodiment 1, the thickness of the thickness of compositions coat and the gel layer of Kelo-cote product is suitable.
What in embodiment 1, the testing vapor transmission of compositions adopted is moisture vapor transmission cup weight method, and test instrunment is that PERME wins close water vapor permeation rate tester.In embodiment 1, the reference sample of the testing vapor transmission of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, crosses and within 20 minutes, to allow in compositions after D5 volatilization, measure its water vapor transmittance, then divided by the water vapor transmittance of pure collagen film.In embodiment 1, Silica hydrogel compositions is coated in the water vapor transmittance on collagen film is 62% of the water vapor transmittance of pure collagen film.Illustrate that in embodiment 1, compositions has certain water vapor rejection performance.
That in embodiment 1, the permeability test of compositions adopts is pressure differential method (GB/T 1038-2000), and test instrunment is Jinan blue streak Labthink VAS-VBS air permeability tester.In embodiment 1, the reference sample of the permeability test of compositions is collagen film.Method of testing is coated on collagen film by Silica hydrogel compositions in embodiment 1, crosses and within 20 minutes, to allow in compositions after D5 volatilization, measure its permeability, then divided by the permeability of pure collagen film.In embodiment 1, Silica hydrogel compositions is coated in 77 % that the permeability on collagen film is the permeability of pure collagen film.Illustrate that in embodiment 1, compositions has good permeability.
What in embodiment 1, the evaluation of the treating acne effect of compositions adopted is Hypertrophic rabbit ear scar model.The card punch that the rabbit ear facies ventralis diameter divided in the New Zealand white rabbit of 4 2.5-3 kg is about 1 cm forms a sphere shaped markup, every ear 6 place, and interval is greater than 1 cm, avoids blood vessel, skin and lower perichondrium thereof in excision circle, cartilage-preserving.Wound polyurethane film is covered to healing.Wound on New Zealand white rabbit ear is left intact in contrast (A group).Wound on another ear once, is treated 30 days (B group) with compositions coating in embodiment 1 every day.Put to death white rabbit when the 36th day, cut the holostrome rabbit ear tissue specimen at scar tissue place at cicatrix peak, fixing in formalin, after paraffin embedding, section, serial dehydration, transparent, hematoxylin-eosin staining, carry out histological observation.Cicatrix index (HI) is for cicatrix peak is to distance (s) and the cicatrix periphery normal skin surface on perichondrium surface to the ratio (HI=s/n) of the distance (n) on perichondrium surface.The method that experimental data is checked with t carries out statistical procedures, and p< 0.05 has statistical significance for difference.The average scar hypertrophy index of matched group (A group) is 1.86, and the average scar index for the treatment of group (B group) is 1.17.A, B group is compared, p <0.01.Above data illustrate, in embodiment 1, compositions has the effect significantly suppressing scar hyperplasia.
In embodiment 1, the sun protection of compositions is evaluated by SPF (sun protection factor) SPF (sun protection factor), and test instrunment is the SPF-290S ultraviolet SPF (sun protection factor) measuring system of Optometrics company of the U.S..Method of testing Silica hydrogel compositions in embodiment 1 is coated on the 3M transpore adhesive tape of simulation human body skin, then measures spf value with SPF-290S.In embodiment 1, the SPF (sun protection factor) SPF of Silica hydrogel compositions is 24.5 (>15), illustrates that in embodiment 1, compositions has good anti-ultraviolet property.
Claims (9)
1. an anti-ultraviolet Silica hydrogel compositions, comprises crosslinked polydimethylsiloxane, polydimethylsiloxane, annular siloxane, it is characterized in that: also containing titanium dioxide nano-particle, zinc oxide nano-particle.
2. the anti-ultraviolet Silica hydrogel compositions of one according to claim 1, is characterized in that: described crosslinked polydimethylsiloxane accounts for by weight 15% 45% of described compositions; Polydimethylsiloxane accounts for by weight 1% 15% of described compositions; Annular siloxane accounts for by weight 30% 70% of described compositions; Titanium dioxide nano-particle accounts for by weight 1% 10% of described compositions; Zinc oxide nano-particle accounts for by weight 1% 10% of described compositions.
3. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: described annular siloxane is D5; Described five siloxanes account for by weight 40% 60% of described compositions.
4. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: described polydimethylsiloxane viscosity is between 10 cSt 100000 cSt.
5. the anti-ultraviolet Silica hydrogel compositions of one according to claim 4, is characterized in that: described polydimethylsiloxane viscosity is between 1000 cSt 30000 cSt.
6. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: lipophile process has been carried out on described zinc oxide nano-particle surface, and particle diameter is between 10-60 nm.
7. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: described titanium dioxide nano-particle accounts for by weight 1% 5% of described compositions.
8. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: described polydimethylsiloxane accounts for by weight 5% 10% of described compositions.
9. the anti-ultraviolet Silica hydrogel compositions of one according to claim 2, is characterized in that: described crosslinked polydimethylsiloxane accounts for by weight 25% 40% of described compositions.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168045A (en) * | 2015-09-07 | 2015-12-23 | 天津嘉氏堂科技有限公司 | Scar sun-screening and repairing silicon gel and preparation method thereof |
| CN106517307A (en) * | 2016-10-31 | 2017-03-22 | 苏州宇希新材料科技有限公司 | Preparation method for oil soluble nano zinc oxide |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
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| CN102802572A (en) * | 2009-06-18 | 2012-11-28 | 先进生物技术公司 | Silicone scar treatment preparation |
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| CN102802572A (en) * | 2009-06-18 | 2012-11-28 | 先进生物技术公司 | Silicone scar treatment preparation |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168045A (en) * | 2015-09-07 | 2015-12-23 | 天津嘉氏堂科技有限公司 | Scar sun-screening and repairing silicon gel and preparation method thereof |
| CN105168045B (en) * | 2015-09-07 | 2018-07-17 | 天津嘉氏堂科技有限公司 | A kind of sun-proof reparation Silica hydrogel of scar and preparation method |
| CN106517307A (en) * | 2016-10-31 | 2017-03-22 | 苏州宇希新材料科技有限公司 | Preparation method for oil soluble nano zinc oxide |
| CN106517307B (en) * | 2016-10-31 | 2017-12-01 | 苏州宇希新材料科技有限公司 | A kind of preparation method of oil solubility nanometer zinc oxide |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
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Application publication date: 20150722 |