CN110121368A

CN110121368A - Silicon resin composition, preparation method and the treating acne agent comprising it

Info

Publication number: CN110121368A
Application number: CN201780081658.1A
Authority: CN
Inventors: 朴一圭; 金炫廷; 姜辉珠
Original assignee: GENEWEL CO Ltd
Current assignee: GENEWEL CO Ltd
Priority date: 2016-12-28
Filing date: 2017-12-15
Publication date: 2019-08-13
Also published as: WO2018124572A1; KR101921727B1; JP6821054B2; JP2020501868A; KR20180076871A

Abstract

The present invention relates to a kind of silicon resin composition, preparation method and comprising its treating acne agent, the silicon resin composition includes: a) silicone resin of 5~70 weight %, b) wax of 0~40 weight %, c) emulsifier of 1~15 weight %, d) drug of 0.01~10 weight %, e) activator of 0.01~10 weight %, f) UV blockers of 0~30 weight %, g) antioxidant of 0~5 weight %, h) water of 0~80 weight % and the i) preservative agent of 0.1~5 weight %.A kind of silicon resin composition is provided according to the present invention, preparation method and treating acne agent comprising it, harmless biocompatibility raw material is used in the silicon resin composition, therefore safety, and it is soft and inviscid when smearing and facilitate, it is quick-drying to be formed simultaneously thin silicon films and protect scar and form moist environment, pass through ultraviolet blocking-up and anti-oxidation efficacy, there is special efficacy to the erythema or pigmentation of preventing and improve scar, and pass through high occlusive effect and dermalaxia, improve the absorption of drug and activator, i.e., improve the absorption of active constituent, therefore, compared with prior art, soften scar more and flat, to prevent, synergistic effect is generated in terms for the treatment of and improvement scar, and there is excellent flexibility, waterproofness and moisture retention.

Description

Silicon resin composition, preparation method and the treating acne agent comprising it

Technical field

The present invention relates to a kind of silicon resin composition, preparation method and treating acne agent comprising it to relate in more detail And a kind of silicon resin composition, preparation method and the treating acne agent comprising it, use is to people in the silicon resin composition The harmless biocompatibility raw material of body, therefore safety, and while smearing is soft and inviscid and facilitate, shape while rapid draing Scar is protected at thin silicon films and forms moist environment, by ultraviolet blocking-up and anti-oxidation efficacy, to prevention and improves scar Erythema or pigmentation have special efficacy, and by high occlusive effect (high occlusive property) and skin it is soft Change, improves the absorption of drug and activator, that is, improve the absorption of active constituent, therefore, compared with prior art, make scar more Add softening and flat, to generate synergistic effect in terms of preventing, treating and improving scar, and with excellent flexibility, Waterproofness and moisture retention.

Background technique

For scar tissue, when skin or corium injured (cutting or burn etc.), our body starts to carry out substantially Accurate and quick wound healing reaction, to generate the scar group of a part of the reconstruction or repair process as damaged tissues It knits.But rebuild or repair process when not adjusted well, even normal agglutination, also result in excessively Scar and pain.

Scar and the skin of surrounding the color of skin, roughness or in terms of difference occurs, when scar occurs In external portion, lead to serious stress, and the scar at the position stretched caused to be damaged its skin histology again, Therefore the treatment time needed is long, and thus the contraction of caused surrounding tissue causes big inconvenience to life.

It is disclosed in the prior art using Silica hydrogel piece or silicon ointment and prevents or improve the method etc. of scar, but existed Following problems: viscosity cause it is inconvenient for use, the therapeutic effect of scar it is not anticipated that it is good, and prevent pigmentation or erythema It is not sufficiently effective.

[existing technical literature]

[patent document]

KR published patent the 2013-0120537th

Summary of the invention

Technical problems to be solved

In the prior art as described above in order to solve the problems, such as, the purpose of the present invention is to provide a kind of combinations of silicone resin Object, preparation method and the treating acne agent comprising it use harmless bio-compatible in silicon resin composition Property raw material, therefore safety, and while smearing is soft and inviscid and facilitate is quick-drying to be formed simultaneously thin silicon films and protect scar Trace simultaneously forms moist environment, by ultraviolet blocking-up and anti-oxidation efficacy, to the erythema or pigmentation for preventing and improving scar With special efficacy, and by high occlusive effect and dermalaxia, improve the absorption of drug and activator, that is, improve active constituent Absorption therefore compared with prior art, soften scar more and flat, thus in terms of preventing, treating and improving scar Synergistic effect is generated, and there is excellent flexibility, waterproofness and moisture retention.

Above-mentioned purpose of the invention and other purposes can be realized by invention described below.

Technical solution

To achieve the goals above, the present invention provides a kind of silicon resin composition, characterized by comprising: a) 5~70 weight The silicone resin of amount %, b) wax of 0~40 weight %, c) emulsifier of 1~15 weight %, d) drug of 0.01~10 weight %, E) activator of 0.01~10 weight %, f) UV blockers of 0~30 weight %, g) antioxidant of 0~5 weight %, H) water of 0~80 weight % and i) preservative agent of 0.1~5 weight %.

In addition, the present invention provides a kind of preparation method of silicon resin composition, which comprises the following steps: A) At 60~80 DEG C, by the silicone resin of 5~70 weight %, the wax of 0~40 weight %, 1~15 weight % emulsifier and 0~30 The UV blockers of weight % are stirred and mix；And B) 0.01~10 weight is added into the mixed mixture Measure the drug of %, the activator of 0.01~10 weight %, the antioxidant of 0~5 weight %, the water of 0~80 weight % and 0.1~ The preservative agent of 5 weight %, and be stirred and mix at 45~70 DEG C.

In addition, the present invention provides a kind for the treatment of acne agent, which is characterized in that include the silicon resin composition.

Beneficial effect

According to the present invention it is possible to provide a kind of silicon resin composition, preparation method and the treating acne agent comprising it, institute It is soft and without viscous when stating in silicon resin composition using harmless biocompatibility raw material, therefore safety, and smearing Property and facilitate, it is quick-drying to be formed simultaneously thin silicon films and protect scar and form moist environment, by ultraviolet blocking-up and anti- Oxidation efficiency has special efficacy to the erythema or pigmentation of preventing and improve scar, and soft by high occlusive effect and skin Change, improves the absorption of drug and activator, that is, improve the absorption of active constituent, therefore, compared with prior art, make scar more Add softening and flat, to generate synergistic effect in terms of preventing, treating and improving scar, and with excellent flexibility, Waterproofness and moisture retention.

Detailed description of the invention

Fig. 1 is the test sequence figure for showing schematically a series of following processes: as confirming the effect for the treatment of acne agent Preparation process, placed 3 weeks after four positions of rabbit ear form identical wound, then confirm the scar of generation, be used in combination Each position is treated in treating acne agent.

Fig. 2 is to carry out histologic analysis (histology analysis), the silicone resin group that will be prepared in embodiment 4 Conjunction object and the scar bought in the market were respectively coated four scars of the subjects prepared in described Fig. 1 with drug, with 1 day 2 coatings 4 weeks, are then dyed (staining) and are used afterwards by tri- color of Masson (Masson's trichrome) decoration method The photo of microscope photographing.

Specific embodiment

Hereinafter, to silicon resin composition of the invention, preparation method and comprising its treating acne agent carry out it is detailed Explanation.

The present inventor's confirmation will add in the silicone compound being made of the silicone resin, wax and emulsifier of predetermined composition ratio Enter drug and activator and the silicon resin composition as needed comprising UV blockers, antioxidant, water and/or preservative agent It is quick-drying to be formed simultaneously thin silicon films (high occlusive effect) and protect scar and form moist environment when being coated on scar (rehydration), it and provides pressure appropriate (light pressure), therefore reduces the permeability of capillary (capillary permeability) and collagen deposition (collagen deposition) and greatly improve scar, and And it is soft and inviscid and easy-to-use when smearing, in particular, compared with prior art, in ultraviolet blocking-up and anti-oxidation efficacy side Face shows synergistic effect, based on this further studied as a result, completing the present invention.

Silicon resin composition of the invention is characterized in that, includes: a) silicone resin of 5~70 weight %, b) 0~40 weight The activation of the wax of amount %, c) emulsifier of 1~15 weight %, d) drug of 0.01~10 weight %, e) 0.01~10 weight % Agent, f) UV blockers of 0~30 weight %, g) antioxidant of 0~5 weight %, h) water of 0~80 weight % and i) The preservative agent of 0.1~5 weight %.

As another example, silicon resin composition of the invention is characterized in that, includes: a) silicon of 5~70 weight % Resin, b) wax of 1~40 weight %, c) emulsifier of 1~15 weight %, d) drug of 0.01~10 weight %, e) 0.01~ The activator of 10 weight %, f) UV blockers of 0~30 weight %, g) antioxidant of 0~5 weight %, h) 0~80 weight The water of amount % and i) preservative agent of 0.1~5 weight %.

As another example, silicon resin composition of the invention is characterized in that, includes: a) silicon of 15~70 weight % Resin, b) wax of 1~40 weight %, c) emulsifier of 1~15 weight %, d) drug of 0.1~10 weight %, e) 0.5~10 The activator of weight %, f) UV blockers of 0~30 weight %, g) antioxidant of 0~5 weight %, h) 0~80 weight The water of amount % and i) preservative agent of 0.1~5 weight %.

As an example, a) silicone resin can be selected from silicone elastomer, film forming agent, silicon fluid and annular siloxane In three kinds or more, in this case, have the effect that due to being harmless biocompatibility raw material, Safety, and while smearing, is soft and inviscid and facilitate, it is quick-drying to be formed simultaneously thin silicon films and protect scar and formed wet Moisten environment.

As an example, relative to the silicone resin for amounting to 100 weight %, a) silicone resin can be 2~75 weights Measure the silicone elastomer of %, the film forming agent of 0.5~20 weight %, the silicon fluid of 0.5~45 weight % and the ring-type of 0~80 weight % The mixing of siloxanes is had the effect that in the range due to being harmless biocompatibility raw material, peace Entirely, soft and inviscid and facilitate when and smearing, it is quick-drying to be formed simultaneously thin silicon films and protect scar and formed wet Environment.

As another example, relative to the silicone resin for amounting to 100 weight %, a) silicone resin can be 5~50 weights Measure the silicone elastomer of %, the film forming agent of 2~10 weight %, the silicon fluid of 2~40 weight % and the cyclic annular silicon of 0.1~65 weight % The mixing of oxygen alkane is had the effect that in the range due to being harmless biocompatibility raw material, safe, And it is soft and inviscid and facilitate when smearing, it is quick-drying to be formed simultaneously thin silicon films and protect scar and form wet ring Border.

As another example, relative to the silicone resin for amounting to 100 weight %, a) silicone resin can be 10~50 weights Measure the silicone elastomer of %, the film forming agent of 2~10 weight %, the silicon fluid of 2~40 weight % and the cyclic annular silicon oxygen of 5~65 weight % The mixing of alkane is had the effect that in the range due to being harmless biocompatibility raw material, safe, and And it is soft and inviscid and facilitate when smearing, it is quick-drying to be formed simultaneously thin silicon films and protect scar and form moist environment.

As an example, it is 100 that the silicone elastomer, which can be weight average molecular weight, 000g/mol or more or 100,000 The silicon polymer of the crosslinking of~10,000,000g/mol.

As another example, the silicone elastomer can be dimethyl silicone polymer or poly dimethyl silicon selected from crosslinking Siloxane derivative, stearyl methyl-dimethyl silicone copolymers, GRANSIL GCM-5, cetearyl polydimethylsiloxanes Alkane-vinyl dimethicone cross polymer, dimethyl silicone polymer-phenyl vinyl dimethyl silicone polymer crosslinking One or more of polymer and dimethyl silicone polymer-vinyl dimethicone cross polymer.

Weight average molecular weight can pass through gel permeation chromatography (gel permeation in the present invention Chromatography it) measures.

As an example, the silicon fluid can be non-volatile silicon fluid, preferably non-volatile silicone oil, specifically Example can be according to ASTM D445, IP71 and (flying generation, you are scientific and technological used as the Ubbelohde viscometer of glass capillary tube viscometer Company manufacture) measurement the viscosity at 25 DEG C be 2~105,000cts, 4~95,000cts, 1,000~14,000cts or The volatile silicone oils of 11,000~14,000cts have the effect of that durability and property easy to apply are excellent in the range.

As another example, the silicon fluid that it is 1~20cst or 1~10cst selected from above-mentioned viscosity that silicon fluid, which can be, (1), above-mentioned viscosity is the silicon fluid (2) of 10,000~15,000cst or 11,000~14,000cst and above-mentioned viscosity is 80,000~120,000cst or 90, one or more of silicon fluid (3) of 000~110,000cst, preferably above-mentioned viscosity It is 80,000~120 for the silicon fluid (2) and above-mentioned viscosity of 10,000~15,000cst or 11,000~14,000cst, The mixing of the silicon fluid (3) of 000cst or 90,000~110,000cst, most preferably above-mentioned viscosity be 1~20cst or 1~ The silicon fluid (3) that the silicon fluid (1) of 10cst and above-mentioned viscosity are 80,000~120,000cst or 90,000~110,000cst Mixing, in this case, sense of touch is excellent, and has the effect of that durability and property easy to apply are excellent.

As an example, the weight ratio of the silicon fluid (1) and the silicon fluid (3) can be 1:0.1~0.9,1: 0.1~0.5 or 1:0.15~0.4, in the range, sense of touch is excellent, and has the effect of that durability and property easy to apply are excellent.

As an example, the weight ratio of the silicon fluid (2) and the silicon fluid (3) can be 1:1~5 or 1:1.5 ~2.5, in the range, sense of touch is excellent, and has the effect of that durability and property easy to apply are excellent.

As another example, the silicon fluid can be linear silicon polymer, and specific example can be selected from linear Dimethicone (dimethicone) polymer, linear polydimethylsiloxane- (polydimethylsiloxane) polymer, One or more of polymethy ethylsiloxane and polymethylphenylsiloxane have durability and easily apply in this case The excellent effect of cloth.

As an example, the film forming agent can be one in well known various film forming silicone resin in the technical field Kind, such as can be MQ type silicone resin, T-type silicone resin or their mixing, specific example and can be selected from trimethyl silane One or more of oxygroup esters of silicon acis, ring five dimethyl silicone polymer, propyl silsesquioxane resin and silsesquioxane, at this In the case of kind, improve the mobility and sense of touch of silicon resin composition, and there is the dispersions of other additives such as improvement drug Effect.

As an example, according to ASTM D445, IP71 and viscous used as capillary glass tube for the film forming agent The viscosity of the film forming agent at 25 DEG C of Ubbelohde viscometer (ThermoFisher Scientific Company manufacture) measurement of degree meter can be 200 ~2,000cst, 300~1,500cst or 400~1,000cst, in the range, improve silicon resin composition mobility and Sense of touch, and have the effect of improving the dispersion of other additives such as drug.

When the annular siloxane is annular siloxane usually used in the technical field, it is not particularly limited, such as Can be hyper-methylation annular siloxane, specific example can be cyclotetrasiloxane selected from octamethylcy-clotetrasiloxane etc., One of cyclohexasiloxane of six siloxanes of the cyclopentasiloxane of decamethylcyclopentaandoxane etc. and ten diformazan basic rings etc. with On.

As an example, a) silicone resin can be 15~65 weight %, 20~65 weight %, 15~40 weights %, 15~30 weight % or 15~25 weight % are measured, are had the effect that in the range due to being harmless biology Compatibility raw material, therefore safety, and while smearing, is soft and inviscid and facilitate, it is quick-drying to be formed simultaneously thin silicon films and protect Shield scar simultaneously forms moist environment.

As an example, the b) wax can be one in beeswax, paraffin, the smooth olive oleate of sorb and silicon wax Kind or more, in this case, have the effect of promoting the stability and smear of preparation.

As an example, the b) wax can be 1~30 weight %, 1~25 weight %, 1~15 weight %, 3~10 Weight %, 4~8 weight % or 5~7 weight % have the effect of promoting the stability and smear of preparation in the range.

As an example, the fatty alcohol (fatty that it is 15~26 selected from carbon atom number that the c) emulsifier, which can be, Alcohols) and one or more of silicon emulsifier, in this case, have the effect that the emulsifying effectiveness of script is excellent, And due to using harmless biocompatibility raw material, safety, when smearing, is soft and inviscid and facilitates.

As an example, the c) emulsifier can for 1~10 weight %, 2~8 weight %, 2~7 weight % or 2~ 5 weight % have the effect that the emulsifying effectiveness of script is excellent in the range, and while smearing it is soft and inviscid and just Benefit.

As an example, the fatty alcohol (fatty alcohols) that the carbon atom number is 15~26 can be carbon atom The fatty alcohol that the fatty alcohol or carbon atom number that number is 15~23 are 16~20, preferably can be cetanol.

As an example, when the silicon emulsifier is silicon emulsifier usually used in the technical field, not by special Limitation, such as can be and emulsified selected from PEG eka-silicon emulsifier, branched chain type polyglycereol eka-silicon emulsifier and cross-linking type polyglycereol eka-silicon Silicon resin composition is maintained at the excellent effect of homogenized condition in this case by one or more of agent.

As an example, the above-mentioned viscosity of the silicon emulsifier can be 1,000~5,000cst, 1,500~2, Silicon resin composition is maintained at the excellent effect of homogenized condition in the range by 500cst or 1,600~2,000cst.

As an example, the polyglycereol eka-silicon emulsifier can be the polyglycerol-modified polydimethylsiloxanes of cross-linking type Alkane, specific example can be selected from -3 disiloxane dimethyl silicone polymer of polyglycereol, -3 poly dimethyl silicon hydroxyl second of polyglycereol Base dimethyl silicone polymer, -3 poly dimethyl silicon ethoxy dimethyl silicone polymer of lauryl polyglycereol, dimethyl silicone polymer - - 3 cross-linked polymer of polyglycereol, -3 cross-linked polymer of lauryl dimethicone/polyglycereol, -9 poly dimethyl of polyethylene glycol Silicon ethoxy dimethyl silicone polymer, dimethicone copolyol, Abil EM 90, PEG-10 One or more of -7 dimethyl silicone polymer of dimethyl silicone polymer and polyethylene glycol.

As an example, for the emulsifier, the parent measured by Griffin method (Griffin's method) Water lipophile balance (hydrophile-lipophile balance, HLB) can be 1~14, preferably can be 2~11, at this In range, silicon resin composition is maintained to the excellent effect of homogenized condition.

As an example, the d) drug can be logical selected from antioxidant, anticancer agent, antiphlogistic, hormone preparation and calcium One or more of road retarding agent, in this case, by anti-oxidation efficacy etc., to the erythema or color for preventing and improving scar It is plain calm with special efficacy, and by quickly absorbing, there is synergistic effect in terms of preventing, treating and improving scar.

As an example, the d) drug can for 0.1~5 weight %, 0.1~3 weight %, 0.1~2 weight %, 0.5~2 weight %, 1~2 weight % or 1.5~2 weight %, in the range, by anti-oxidation efficacy etc., to preventing and change The erythema or pigmentation of kind scar have special efficacy, and by quickly absorbing, have in terms of preventing, treating and improving scar Synergistic effect.

As an example, the antioxidant can be ascorbic acid derivates, in this case, antioxidant effect And treating acne significant effect.

The ascorbic acid derivates are Vitamin C that is usually used in the technical field or can buying on the market It when acid derivative, is not particularly limited, such as can be the ascorbic acid being acylated by single or multiple fatty acid groups and conduct The ascorbic acid aliphatic ester of its salt, specific example can be selected from ascorbyl dodecanoate, ascorbic acid myristic acid The different palmitate of ester, ascorbyl palmitate, ascorbic acid, ascorbic acid -6- palmitate, ascorbyl stearate, One or more of ascorbic acid behenate and their metal salt, preferably can be Ascorbyl Tetraisopalmitate.

As an example, the anticancer agent can be 5 FU 5 fluorouracil, bleomycin etc..

As an example, the antiphlogistic can be dipotassium glycyrrhizinate, allantoin or their mixing, preferably allantois Element when being used together with water, can be used together with the chelating agent of such as EDETATE SODIUM etc., in this case, anti-inflammatory effects and Skin sedation excellent effect.

As an example, the weight ratio of the allantoin and EDETATE SODIUM can for 1:0.01~1:0.5,1:0.05~ 1:0.2 or 1:0.08~1:0.12, in the range, anti-inflammatory effects and skin sedation excellent effect.

As an example, the hormone preparation can be triamcinolone, and in this case, having improves and treat scar Effect.

As an example, the calcium channel blocker can be Verapamil, and in this case, the treatment of scar is imitated Fruit is excellent.

As an example, the e) activator can be selected from vitamin derivative and Bulbus Allii Cepae extract (Allium One or more of Cepa), in this case, the effect inside scar is absorbed into together with drug to be improved, therefore, Compared with prior art, synergistic effect is generated in terms of preventing, treating and improving scar.

As an example, the e) activator can be 1~5 weight %, 1~5 weight %, 2~5 weight % or 2~3 Weight %, in the range, the effect inside scar is absorbed into together with drug to be improved, therefore, with prior art phase Than generating synergistic effect in terms of preventing, treating and improving scar.

Vitamin derivative and Bulbus Allii Cepae extract are that can use in the technical field or can be in market in the present invention When the vitamin derivative of upper purchase, it is not particularly limited.

As an example, the vitamin derivative can be selected from vitamin A, vitamin C, vitamin D and dimension life One or more of the derivative of plain E is absorbed into the effect inside scar together with drug and is changed in this case It is kind, therefore, compared with prior art, synergistic effect is generated in terms of preventing, treating and improving scar.

As an example, the Bulbus Allii Cepae extract can be the extract of the dry onion containing water, alcohol or water-alcohol, tool The example of body can be as follows: at 40~90 DEG C, will be known as the dry onion sheet obtained from onion maternal plant (stock plant) Dry onion, extract its ingredient using Extraction solvent, then under reduced pressure and 30 DEG C or more of rising at a temperature of, make above-mentioned Solution (leachate) evaporation is extracted, Bulbus Allii Cepae extract is obtained, the onion that subsequent dissolution obtains liquid in water, alcohol or water-alcohol mentions Take object.

As an example, in the Bulbus Allii Cepae extract of the liquid, the solvent can be 5~60 weight %, 10~50 Weight %, 10~40 weight % or 10~15 weight %.

As an example, the alcohol can be selected from one of ethyl alcohol, isopropanol, propyl alcohol, butanediol and propylene glycol More than.

The weight of Bulbus Allii Cepae extract is on the basis of solid content in the present invention.

As specific example, the Bulbus Allii Cepae extract can be prepared as follows:

As an example, dry onion can use essence with the ratio of the drug (dry onion) of 1:16 and Extraction solvent (water) Water processed extracts.The ratio of dry drug and natural extract is equivalent to 1.8:1 or 1.5~2.2:1.Dry drug with The ratio of liquid extract is 0.16:1.Drug (for example, onion sheet of 16kg) is only with (80~90 DEG C) of hot water leachings.Later, Under reduced pressure and at 55 DEG C or more, leachate is evaporated, obtained Bulbus Allii Cepae extract (extract of concentration).Wherein, it carries out of short duration Heating (being carried out 3 seconds at 141 DEG C).The Bulbus Allii Cepae extract of generation is the liquid of concentration, is dissolved in water, alcohol or water-alcohol The liquid extract of aforementioned proportion is obtained in mixture.Wherein, the liquid of rufous or brown with characteristic fragrance is made. The extract can be mixed with arbitrary proportion with water, with the relative density of 1.00~1.03g/mL at 20 DEG C.Processed When using water/alcohol (in particular, ethyl alcohol) in journey, may exist the alcohol (for example, ethyl alcohol) of about 13~20% (v/v).Dry is residual Object (at 105 DEG C after 2 hours) is stayed to be at least 7.0% (m/m).About microbiological purity, product meets Deutscher Arzneibucs (German Pharmacopeia) the requirement of 10 entry 3.

As an example, the f) UV blockers can be inorganic UV blocking agent, organic uv blocks Agent and their mixing have special efficacy to the erythema or pigmentation of preventing and improve scar in this case.

As an example, the f) UV blockers can for 0.1~30 weight %, 0~20 weight %, 0.1~ 20 weight %, 0~15 weight % or 0.1~15 weight % are in the range, heavy to the erythema or pigment of preventing and improve scar Have special efficacy.

When the inorganic UV blocking agent is the inorganic UV blocking agent that usually can be used in the technical field, no It is particularly limited, it is preferred that can be zinc oxide, titanium oxide or their mixing, preferably zinc oxide, in this case, There is special efficacy to the erythema or pigmentation of preventing and improve scar.

When the organic uv blocking agent is the organic uv blocking agent that usually can be used in the technical field, no It is particularly limited, it is preferred that can be in octyl methoxycinnamate, octyl salicylate, Octocrilene and Avobenzone More than one, preferably octyl methoxycinnamate is in this case, heavy to the erythema or pigment of preventing and improve scar Have special efficacy.

As another example, the UV blockers can be the benzophenone selected from dihydroxy benaophenonel etc. Class, melanin, ethylaminobenzoate, p-(dimethylamino)-benzoic acid 2- ethylhexyl, Cinoxate, p-methoxycinnamic acid 2- ethylhexyl, 2- (2- hydroxy-5-methyl base phenyl) benzotriazole, urocanic acid, ortho-aminobenzoic acid, cinnamate, salicylic acid Ester, the derivative of dibenzoyl methane, the derivative of camphor, the derivative of triazine, the derivative of benzophenone, β, β '-hexichol The derivative of base acrylate, the derivative of benzotriazole, the derivative of benzyl malonic acid ester, benzimidazole derivative, miaow One or more of oxazoline, the derivative of benzo allyl, the derivative of p-aminobenzoic acid, titanium oxide and zinc oxide etc..

As an example, the h) water can for 0.1~80 weight %, 30~80 weight %, 45~70 weight % or 50~65 weight %, in the range, sufficiently dissolution drug, activator and antioxidant etc., when smearing it is soft and inviscid and It is convenient, and help quick-drying to be formed simultaneously thin silicon films.

As an example, the h) water can be Purified Water or distilled water.

As an example, the g) antioxidant can be 0.1~5 weight %, 0.5~3 weight % or 0.5~2 weight % is measured, in the range, there is effect to the erythema or pigmentation of preventing and improve scar.

When antioxidant is antioxidant usually used in the technical field in the present invention, it is not particularly limited, such as It can be selected from one or more of butylated hydroxy anisole, gallic acid, propylgallate and arabo-ascorbic acid.

As an example, the f) preservative agent can be selected from imidazolidinyl urea (Imidazolidinyl Urea), right Methyl hydroxybenzoate (Methylparaben), salicylic acid (Salicylic acid), methylchloroisothiazandnone (Methylchloroisothiazolinone), methylisothiazolinone (Methylisothiazolinone), para hydroxybenzene Ethyl formate (Ethylparaben), butyl p-hydroxybenzoate (Butylparaben), propylparaben (Propylparaben), p-Hydroxybenzoic acid isopropyl ester (Isopropylparaben), Phenoxyethanol (Phenoxyethanol), DMDM hydantoin (DMDM Hydantoin), 1,2- hexylene glycol (1,2-Hexanediol), decoyl Glycine, glycerol caprylate, levulic acid sodium, zinc gluconate, copper gluconate, zinc pyrrolidone carboxylate, pyrrolidones carboxylic Sour copper, phytosphingosine, Phytosphingosine derivate, benzoyl peroxide, piroctone olamine salt, zinc pyrithione, sulphur Change one or more of selenium, econazole, ketoconazole, erythromycin and clindamycin, preferably 1,2- hexylene glycol, in such case Under, the preservation effect of silicon resin composition is excellent.

The preparation method of silicon resin composition of the invention is characterised by comprising following steps: A) at 60~80 DEG C, By the ultraviolet of the silicone resin of 5~70 weight %, the wax of 1~40 weight %, the emulsifier of 1~15 weight % and 0~30 weight % Line blocking agent is stirred and mixes；And B) into the mixed mixture be added 0.01~10 weight % drug, The guarantor of the activator of 0.01~10 weight %, the antioxidant of 0~5 weight %, the water of 0~80 weight % and 0.1~5 weight % Agent is deposited, and is stirred and mixes at 45~70 DEG C.

The step A) and step B) used in ingredient include all above-mentioned contents.

As an example, the step A) in mixing can at 60~75 DEG C, 65~70 DEG C or 63~67 DEG C into Row.

As an example, the step B) in, at 50~75 DEG C, the drug or part of it and water are mixed Close and prepare mixed solution, the mixed solution is charged first to the step A) in prepare mixture in and mix, then The activator, antioxidant and preservative agent can be added, in this case, have the effect that and be uniformly dispersed, therefore make Standby silicon resin composition can mildly be applied to skin and inviscid therefore easy-to-use, and improve active constituent It absorbs.

As an example, the step B) mixed solution can will be described at 60~70 DEG C or at 63~67 DEG C Drug or part of it are mixed with water and are prepared.

As an example, the mixed solution is added to the step A) in prepare mixture when, the mixing Solution may remain in 50~75 DEG C, has the effect that be uniformly dispersed in the range, therefore the silicon resin composition prepared It can be mildly applied to skin and inviscid therefore easy-to-use, and improve the absorption of active constituent.

As an example, the step B) in, when mixed solution is added to mixture, the mixed solution can be protected It holds at 60~70 DEG C or 63~67 DEG C.

As an example, the mixed solution is added to the step A) in prepare mixture, be subsequently cooled to The activator, antioxidant and preservative agent can be added at 45~55 DEG C, have the effect that dispersion is equal in the range It is even, therefore the silicon resin composition prepared can mildly be applied to skin and inviscid therefore easy-to-use, and improve work The absorption of property ingredient.

As another example, the mixed solution is added to the step A) in prepare mixture, then cool down The activator, antioxidant and preservative agent can be added when to 48~52 DEG C.

Treating acne agent of the invention is characterized in that comprising the silicon resin composition.

Treating acne agent is not limited by its title in the present invention, be may include all preventions, is improved or treat scar Drug, such as may include scar improver, scar inhibitor, scar drug etc..

As an example, the treating acne agent can be piece (sheet) type, white type or gel-type, preferably can be White type or gel-type have the effect that soft and inviscid when smearing and facilitate, can arbitrarily adjust in this case Therapentic part and it is easy, and economy is excellent.

It as an example, can according to the ultraviolet light blocking index (SPE) of the treating acne agent of 24444 standard of ISO Think 25 or more, 30 or more or 30 to 50, in the range, other physical properties of silicon resin composition will not be generated negative It influences, and by ultraviolet blocking-up, there is special efficacy to the erythema or pigmentation of preventing and improve scar.

As an example, according to the antioxidant effect of the treating acne agent of DPPH method can for 40% or more, 45% or more, 50% or more or more than 50%, in the range, other physical properties of silicon resin composition will not be generated negative Face is rung, and by antioxidant effect, has special efficacy to the erythema or pigmentation of preventing and improve scar.

Hereinafter, proposing preferred embodiment, but following embodiments are only used for illustrating this hair to help to understand the present invention Bright, various modifications may be made in the range of scope of the invention and technical idea and modification, this is for those skilled in the art Be for member it is specific, this deformation and modification also belong to the range of claims.

[embodiment]

The ingredient for including in the silicone compound of following Examples and Comparative Examples is following DOW CORNING (Dow Corning) the product of company.

1) silicone elastomer

1-1) ST- elastomer (Elastomer) 10

1-2)TI-3021

2) silicone resin (film forming agent)

2-1) TI-7021 (400~1,000cst)

3) silicon fluid (fluid)

3-1) TI-2021 (2~4cst, for improving sense of touch)

3-2) (various range of viscosities, the product used are 95 to TI-1050, the product of 000~105,000cst, for adjusting Save viscosity)

3-3) Q7-9120 (11,875~13,125cst)

4) annular siloxane

4-1) ST- cyclomethicone (Cyclomethicone) 5-NF

Embodiment 1 (patch-type)

By the silicone compound (Q7-9120:TI-3021:TI-1050: elastomer 10:TI-7021:5-NF=of 64.5g 1:6:2:8:3:80 weight ratio) it is heated to 70 and stirs.The cetanol as emulsifier of the beeswax of 25g and 7g are stirred under 70 It mixes and adds, when being then thoroughly mixed, temperature is reduced to 55, and the ascorbic acid four of the Bulbus Allii Cepae extract of 2g, 0.5g is added The 1,2- hexylene glycol as preservative agent of different palmitate and 1g.It is added in container before complete cooling.

Embodiment 2 (white type or gel-type)

20g silicone compound (TI-1050:TI-2021:TI-3021:TI-7021: elastomer 10=10:30: 20:10:30 weight ratio) in be added 4g silicon emulsifier (Dow corning ES-5300, viscosity 1800mm²/ s) and 7g The smooth olive oleate of sorb, is heated to 65 and stirs.The allantoin of 0.5g, the EDTA of 0.05g are added in another reactor The Purified Water of disodium, 64.45g is heated to 65 and stirs.Under 65, the content of the reactor equipped with Purified Water is slowly fallen Enter in the reactor equipped with silicone resin and stirs.When being mutually thoroughly mixed stop heating, and 50 under addition 2g Bulbus Allii Cepae extract, The 1,2- hexylene glycol as preservative agent of the tocopherol acetate of 1g, 1g.Continue stirring to complete cooling.

Embodiment 3 (white type or gel-type)

20g silicone compound (TI-1050:TI-2021:TI-3021:TI-7021: elastomer 10=10:30: 20:10:30 weight ratio) in be added the zinc oxide of 10g, the octyl methoxycinnamate of 5g, 4g silicon emulsifier (Dow Corning ES-5300, viscosity 1800mm²/ s), the smooth olive oleate of sorb of 5g, be heated to 65 and stir.At another The Purified Water of the allantoin of 0.5g, the EDETATE SODIUM of 0.05g, 51.45g are added in reactor, is heated to 65 and stirs.65 Under, the content of the reactor equipped with Purified Water is poured slowly into the reactor equipped with silicone resin and is stirred.Mutually it is thoroughly mixed When stop heating, and 50 under addition the Bulbus Allii Cepae extract of 2g, the tocopherol acetate of 1g, 1g 1, the 2- as preservative agent oneself Glycol.Continue stirring to complete cooling.

Embodiment 4 (white type or gel-type)

20g silicone compound (TI-1050:TI-2021:TI-3021:TI-7021: elastomer 10=10:30: 20:10:30 weight ratio) in be added 4g silicon emulsifier (Dow corning ES-5300, viscosity 1800mm²/ s) and 7g The smooth olive oleate of sorb, is heated to 65 and stirs.The Verapamil of 0.1g, the allantois of 0.5g are added in another reactor The Purified Water of element, the EDETATE SODIUM of 0.05g and 64.35g, is heated to 65 and stirs.Under 65, the reactor of Purified Water will be housed Content be poured slowly into the reactor equipped with silicone resin and stir.Stop heating when being mutually thoroughly mixed, and is added under 50 The Bulbus Allii Cepae extract of 2g, the tocopherol acetate of 1g, 1g the 1,2- hexylene glycol as preservative agent.Continue to stir to completely cold But.

Embodiment 5 (white type or gel-type)

20g silicone compound (TI-1050:TI-2021:TI-3021:TI-7021: elastomer 10:5-NF=5: 30:25:10:25:5 weight ratio) in be added 4g silicon emulsifier (Dow corning ES-5300, viscosity 1800mm²/ s) and The smooth olive oleate of the sorb of 7g, is heated to 65 and stirs.The Verapamil of 0.1g, 0.5g is added in another reactor The Purified Water of allantoin, the EDETATE SODIUM of 0.05g and 64.35g is heated to 65 and stirs.It, will be anti-equipped with Purified Water under 65 It answers the content of device to be poured slowly into the reactor equipped with silicone resin and stirs.Stop heating when being mutually thoroughly mixed, and under 50 The 1,2- hexylene glycol as preservative agent of the Bulbus Allii Cepae extract of 2g, the tocopherol acetate of 1g, 1g is added.Continue to stir to complete It is cooling.

Embodiment 6 (does not contain wax pattern)

40g silicone compound (Q7-9120:TI-1050:TI-3021:TI-7021: elastomer 10=1:6:13: 5:75 weight ratio) in the silicon emulsifier of 4g is added (Dow corning Emulsifier 10, HLB ratio is 2.2%, and viscosity is 1100~3500cps or cst), and stir at normal temperature.The allantoin of 0.5g, 0.05g is added in another reactor The Purified Water of EDETATE SODIUM and 55.45g is heated to 60 and stirs.Reactor equipped with Purified Water is completely cooling, then by it Content is poured slowly into the reactor equipped with silicone resin and stirs.When being mutually thoroughly mixed, high-speed stirred is carried out using homogenizer.

Comparative example 1~4 (the treating acne agent that can be bought on the market)

Kelo-cote external-use gel (Topical Gel) (Formulated is used respectively as comparative example 1~4 Solution LLC company manufacture), Kelo-cote Solaire (manufacture of Formulated Solutions LLC company), Dermatix gel (Dermatix Ultra gel) (manufacture of Toshiki International Singapore Pte company) And Bentlax gel (gel) (Tai Guk drugmaker).

[test example]

The scar of the silicon resin composition and comparative example 1~4 that prepare in the embodiment 4~5 is measured by following methods The characteristic of trace therapeutic agent, the results are shown in the following table 1 and Fig. 2.

* it antioxidant effect: is measured by DPPH method, numerical value is higher, then more shows excellent antioxidant effect.

* ultraviolet light blocks performance (SPF): according to ISO 2444, being measured by human body patch test.

* sticky degree: measure on the basis of sense of touch when sample to be applied to skin, be expressed as when inviscid +++, it glues Property it is common when be expressed as ++, viscosity it is very big when be expressed as+.

[table 1]

It distinguishes	Embodiment 4	Embodiment 5	Comparative example 1	Comparative example 2	Comparative example 3	Comparative example 4
							Antioxygenic property	52	53	1	10	2	38
Ultraviolet light blocks performance	32	30	0	30	0	0
							Viscosity	+++	+++	+	+	+++	++

As shown in table 1, compared with the comparative example 1~4 for belonging to the prior art, silicon resin composition of the invention can be confirmed (embodiment 4,5) there is excellent antioxygenic property and ultraviolet light to block performance, and when smearing is soft and absolutely not sticky.

In addition, as shown in Fig. 2, silicone resin of the invention can be confirmed compared with as the comparative example 3 of the prior art and 4 Abnormal collagen (disorganized collagen) is greatly decreased in composition (embodiment 4), and makes normal glue Former albumen (normal pattern collagen) increases.

Claims

1. a kind of silicon resin composition is, characterized by comprising: a) silicone resin of 5~70 weight %, b) 0~40 weight % Wax, c) emulsifier of 1~15 weight %, d) drug of 0.01~10 weight %, e) activator of 0.01~10 weight %, f) 0 The UV blockers of~30 weight %, g) antioxidant of 0~5 weight %, h) water of 0~80 weight % and i) 0.1~5 weight Measure the preservative agent of %.

2. silicon resin composition according to claim 1, which is characterized in that a) silicone resin be selected from silicone elastomer, Three kinds or more in film forming agent, silicon fluid and annular siloxane.

3. silicon resin composition according to claim 2, which is characterized in that relative to amount to 100 weight % silicone resin, A) the silicone resin is the silicon stream of the silicone elastomer of 2~75 weight %, the film forming agent of 0.5~20 weight %, 0.5~45 weight % The mixing of the annular siloxane of body and 0~80 weight %.

4. silicon resin composition according to claim 1, which is characterized in that the b) wax is selected from beeswax, paraffin, sorb One or more of smooth olive oleate and silicon wax.

5. silicon resin composition according to claim 1, which is characterized in that the silicon resin composition includes 1~40 weight Measure the b) wax of %.

6. silicon resin composition according to claim 1, which is characterized in that the c) emulsifier is to be selected from carbon atom number One or more of 15~26 fatty alcohol and silicon emulsifier.

7. silicon resin composition according to claim 1, which is characterized in that the d) drug is selected from antioxidant, disappears One or more of scorching agent and calcium channel blocker.

8. silicon resin composition according to claim 1, which is characterized in that the e) activator is selected from vitamin-derived One or more of object and Bulbus Allii Cepae extract.

9. silicon resin composition according to claim 1, which is characterized in that the f) UV blockers are inorganic UVs Line blocking agent, organic uv blocking agent and their mixing.

10. silicon resin composition according to claim 1, which is characterized in that the silicon resin composition includes 0.1~30 F) the UV blockers of weight %.

11. silicon resin composition according to claim 1, which is characterized in that the silicon resin composition includes 0.1~5 G) the antioxidant of weight %.

12. silicon resin composition according to claim 1, which is characterized in that the silicon resin composition includes 0.1~80 H) the water of weight %.

13. silicon resin composition according to claim 1, which is characterized in that the f) preservative agent is selected from imidazolidinyl Urea, methyl p-hydroxybenzoate, salicylic acid, methylchloroisothiazandnone, methylisothiazolinone, ethyl-para-hydroxybenzoate, Butyl p-hydroxybenzoate, propylparaben, p-Hydroxybenzoic acid isopropyl ester, Phenoxyethanol, DMDM hydantoin, 1, 2- hexylene glycol, decoyl glycine, glycerol caprylate, levulic acid sodium, zinc gluconate, copper gluconate, 2-pyrrolidone-5-carboxylic acid Zinc, 2-pyrrolidone-5-carboxylic acid's copper, phytosphingosine, Phytosphingosine derivate, benzoyl peroxide, piroctone olamine salt, One or more of zinc pyrithione, selenium sulfide, econazole, ketoconazole, erythromycin and clindamycin.

14. a kind of preparation method of silicon resin composition, which comprises the following steps:

A) at 60~80 DEG C, by the silicone resin of 5~70 weight %, the wax of 1~40 weight %, 1~15 weight % emulsifier And 0~30 the UV blockers of weight % be stirred and mix；And

B) be added into the mixed mixture drug of 0.01~10 weight %, the activator of 0.01~10 weight %, 0~ The preservative agent of the antioxidant of 5 weight %, the water of 0~80 weight % and 0.1~5 weight %, and stirred at 45~70 DEG C It mixes and mixes.

15. the preparation method of silicon resin composition according to claim 14, which is characterized in that the step B) in, At 50~75 DEG C, the drug or part of it and water are mixed and prepare mixed solution, the mixed solution is first added Enter in the mixture prepared into the step A) and mix, the activator, antioxidant and preservative agent is then added.

16. the preparation method of silicon resin composition according to claim 15, which is characterized in that add the mixed solution When entering the mixture prepared into the step A), the mixed solution is maintained at 50~75 DEG C.

17. the preparation method of silicon resin composition according to claim 15, which is characterized in that add the mixed solution Enter the mixture prepared into the step A), is subsequently cooled to that the activator, antioxidant and guarantor are added at 45~55 DEG C Deposit agent.

18. a kind for the treatment of acne agent, which is characterized in that include silicon resin composition described in any one of claims 1 to 13.

19. treating acne agent according to claim 18, which is characterized in that the treating acne agent be piece type, white type or Gel-type.

20. treating acne agent according to claim 18, which is characterized in that controlled according to the scar of ISO24444 standard The ultraviolet light blocking index (SPE) for treating agent is 25 or more.

21. treating acne agent according to claim 17, which is characterized in that according to the treating acne agent of DPPH method Antioxidant effect is 40% or more.