CN113952502A - Multifunctional silicone gel dressing and preparation method thereof - Google Patents
Multifunctional silicone gel dressing and preparation method thereof Download PDFInfo
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- CN113952502A CN113952502A CN202010701501.8A CN202010701501A CN113952502A CN 113952502 A CN113952502 A CN 113952502A CN 202010701501 A CN202010701501 A CN 202010701501A CN 113952502 A CN113952502 A CN 113952502A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
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Abstract
The invention relates to a multifunctional silicone gel dressing and a preparation method thereof, belonging to the field of medical cosmetology. The multifunctional silicone gel dressing comprises silicone, tetrahexyldecanol ascorbate and emulsifier, and its preparation method is disclosed. The invention combines silicone and tetrahexyldecyl ascorbate substances to develop a multi-effect silicone gel dressing. The dressing integrates multiple functional effects: excellent film forming property, water locking property and hydration property, scar removal and itching relief, and scar prevention and treatment; good skin absorbability, and rapid action of effective components; can inhibit melanin generation, and has effects of whitening and brightening skin; can prevent lipid peroxidation and skin aging, and resist oxidation; can promote collagen synthesis and resist aging; can reduce cell or DNA damage caused by UV, and protect against ultraviolet rays.
Description
Technical Field
The invention relates to the field of dressings and production processes thereof, in particular to a multifunctional silicone gel dressing and a preparation method thereof.
Background
After burns, wounds and surgical operations, because the skin soft tissue at the wound healing part is seriously damaged and can not be completely repaired by self, the fibrous tissue replaces the skin soft tissue to form hyperplastic scars or keloids, and local symptoms which influence the skin function and the beauty are left. Nearly 4 million people in China suffer from scars. Scars are troubling people's normal life, study, marriage and the like, and especially when the scars are formed on exposed parts, the scars seriously affect and attack people's self-esteem.
The essence of a scar is an abnormal, incompetent tissue without normal skin tissue structure and physiological function, which loses normal tissue vitality. Scars are always an imperfect replacement for damaged tissue. From a mechanical point of view, the tensile resistance is weakened; from a nutritional perspective, a barrier to oxygen and nutrient communication is formed; from a functional point of view, deformities and dysfunctions of damaged tissues are often caused by contraction and traction. For example, if scar tissue formation is insufficient, the damaged tissue may not be under normal tension, which may cause many complications, such as weakness in the scar that heals the abdominal wall incision, renewed scarring of the scar or gradual bulging of the abdominal contents out under the action of intra-abdominal pressure to form an abdominal hernia. Conversely, if the scar is formed excessively, it can cause serious topographical or functional problems. From the aesthetic point of view, the color and luster of the scars on the skin surface are mostly inconsistent with the surrounding tissues, and some scars have protrusions and recesses and are hard to touch, which is the most clinical treatment reason for patients at present. At present, clinical medicine is mainly treated by means of surgical repair and drug softening, and the treatment method has long period and high cost. Therefore, research on non-operative scar prevention methods and products is a subject of common attention in medical circles at home and abroad.
Silicone gel is a first-line product recommended by medical experts worldwide for treating scars, has the characteristics of low surface tension and water evaporation resistance, can play the same role as the epithelial cuticle, promotes the scar to restore the stability of the internal environment, and relieves the congestion of capillary vessels and the hyperplasia of fibers, thereby preventing the formation of hyperplastic scars. However, the efficacy of the existing gel products is mostly focused on preventing scars, but the efficacy of improving the skin beauty is not satisfactory.
Therefore, there is a need in the art for a multi-effect product that has both scar prevention and treatment effects, and also promotes improved skin cosmetic aesthetics.
Disclosure of Invention
In order to overcome the defects of the existing products, the invention aims to provide a multifunctional silicone gel dressing which overcomes the defects that the traditional silicone gel has relatively few effects, has multiple effects of promoting the skin to be beautified and beautiful and has obvious curative effect.
Meanwhile, the invention also provides a preparation method of the multifunctional silicone gel dressing.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a multifunctional silicone gel dressing comprises dimethicone Q7-9120, dimethicone TI-1050, silicone elastomer TI-3021, silicone resin TI-7021, tetrahexyldecanol ascorbate, and emulsifier.
Dimethyl silicone oil Q7-9120, dimethyl silicone oil TI-1050, silicone elastomer TI-3021, silicone resin TI-7021, tetrahexyldecyl ascorbate, and emulsifier by mixing at a certain ratio to obtain silicone gel dressing. The silicone gel dressing coating forms a protective layer, reduces the water loss through the epidermis, and ensures that scars are softened, smooth and flat under the action of sufficient hydration; the silicone gel dressing coating forms a semi-permeable film within 3 minutes, so that the skin can breathe smoothly, physical, chemical and microorganism are effectively prevented from invading scar positions, itching is effectively relieved, fibroblasts can be generated normally in the protected environment, and abnormal scars are prevented; meanwhile, the deficiency or excess of the growth factors is corrected, and the scar repair is completed through bidirectional adjustment and rearrangement.
As a further aspect of the invention: the tetrahexyldecyl ascorbate is an oil-soluble vitamin C derivative, has the characteristics of excellent transdermal absorbability, melanin generation inhibition, lipid peroxidation prevention and skin aging prevention, collagen synthesis promotion, cell or DNA damage reduction and the like caused by UV, and further has the effects of easy skin absorption, whitening and skin brightening, oxidation resistance, aging resistance and ultraviolet ray resistance.
As a further aspect of the invention: the formula of the multifunctional silicone gel dressing comprises the following components in percentage by weight: 12 percent of dimethyl silicone oil Q7-9120, 12 percent of dimethyl silicone oil TI-1050, 40 percent of organic silicon elastomer TI-3021, 16 percent of organic silicon resin TI-7021, 0.05-3 percent of tetrahexyldecanol ascorbic acid ester and 17-19.95 percent of emulsifier.
As a further aspect of the invention: the viscosity of the simethicone Q7-9120 is 12500cst,
the viscosity of the dimethyl silicone oil TI-1050 is 100000cst, the viscosity of the organic silicon elastomer TI-3021 is 300000cst, and the viscosity of the organic silicon resin TI-7021 is 700mm2/s。
As a further aspect of the invention: the emulsifier is at least one of span 60, span 80, glyceryl monostearate, tween 60 or tween 80.
A preparation method of a multifunctional silicone gel dressing comprises the following steps:
(1) weighing all raw materials;
(2) adding dimethyl silicone oil Q7-9120, dimethyl silicone oil TI-1050, an organic silicon elastomer TI-3021, an organic silicon resin TI-7021 and an emulsifier into an oil phase reaction kettle, heating and stirring, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform;
(3) after stirring uniformly, cooling to room temperature, adding tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min to obtain a dressing;
(4) filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
Preferably, in the step (2), the stirring temperature is 60-70 ℃.
Preferably, in the step (2), the stirring speed is 60-80 rpm.
Preferably, in the step (3), the stirring speed is 90-100 rpm.
The invention has the beneficial effects that: the dressing integrates multiple functional effects: excellent film forming property, water locking property and hydration property, scar removal and itching relief, and scar prevention and treatment; good skin absorbability, and rapid action of effective components; can inhibit melanin generation, and has effects of whitening and brightening skin; can prevent lipid peroxidation and skin aging, and resist oxidation; can promote collagen synthesis and resist aging; can reduce cell/DNA damage caused by UV, and protect against ultraviolet rays.
The preparation method of the multifunctional silicone gel dressing is simple to operate, easy to control and suitable for industrial popularization and application.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art are briefly introduced below.
Fig. 1 is a flow chart of a method for preparing a multifunctional silicone gel dressing according to an embodiment of the invention.
Detailed Description
Example 1
The multifunctional silicone gel dressing comprises the following components in percentage by weight: 12% of dimethyl silicone oil Q7-9120 with the viscosity of 12500cst, 12% of dimethyl silicone oil TI-1050 with the viscosity of 100000cst, 40% of silicone elastomer TI-3021 with the viscosity of 300000cst, 16% of silicone resin TI-7021, 0.05% of tetrahexyldecanol ascorbate, and 19.95% of silicone oil with the viscosity of 700mm2Glycerol monostearate in/s.
The preparation method of the multifunctional silicone gel dressing, as shown in fig. 1, comprises the following steps:
(1) weighing all raw materials;
(2) adding 12g of dimethyl silicone oil Q7-9120, 12g of dimethyl silicone oil TI-1050, 40g of organic silicon elastomer TI-3021, 16g of organic silicon resin TI-7021 and 19.95g of glycerin monostearate into an oil phase reaction kettle, heating and stirring at 65 ℃, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform, wherein the stirring speed is 75 rmp;
(3) after stirring uniformly, cooling to room temperature, adding 0.05g of tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min at the stirring speed of 95rmp to obtain the dressing;
(4) filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
Example 2
The multifunctional silicone gel dressing comprises the following components in percentage by weight: 12% of dimethyl silicone oil Q7-9120 with the viscosity of 12500cst, 12% of dimethyl silicone oil TI-1050 with the viscosity of 100000cst, 40% of silicone elastomer TI-3021 with the viscosity of 300000cst, 16% of silicone resin TI-7021, 1% of tetrahexyldecanol ascorbate, and 19% of silicone oil with the viscosity of 700mm2Glycerol monostearate in/s.
The preparation method of the multifunctional silicone gel dressing, as shown in fig. 1, comprises the following steps:
(1) weighing all raw materials;
(2) firstly, adding 12g of dimethyl silicone oil Q7-9120, 12g of dimethyl silicone oil TI-1050, 40g of organic silicon elastomer TI-3021, 16g of organic silicon resin TI-7021 and 19g of glycerin monostearate into an oil phase reaction kettle, heating and stirring at 65 ℃, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform, wherein the stirring speed is 75 rmp;
(3) after stirring uniformly, cooling to room temperature, adding 1g of tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min at the stirring speed of 95rmp to obtain the dressing;
(4) filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
Example 3
The multifunctional silicone gel dressing comprises the following components in percentage by weight: 12% of dimethyl silicone oil Q7-9120 with the viscosity of 12500cst, 12% of dimethyl silicone oil TI-1050 with the viscosity of 100000cst, 40% of silicone elastomer TI-3021 with the viscosity of 300000cst, 16% of silicone resin TI-7021, 2% of tetrahexyldecanol ascorbate, and 18% of silicone oil with the viscosity of 700mm2Glycerol monostearate in/s.
The preparation method of the multifunctional silicone gel dressing, as shown in fig. 1, comprises the following steps:
(1) weighing all raw materials;
(2) firstly, adding 12g of dimethyl silicone oil Q7-9120, 12g of dimethyl silicone oil TI-1050, 40g of organic silicon elastomer TI-3021, 16g of organic silicon resin TI-7021 and 18g of glycerin monostearate into an oil phase reaction kettle, heating and stirring at 65 ℃, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform, wherein the stirring speed is 75 rmp;
(3) after stirring uniformly, cooling to room temperature, adding 2g of tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min at the stirring speed of 95rmp to obtain the dressing;
(4) filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
Example 4
The multifunctional silicone gel dressing comprises the following components in percentage by weight: 12% of dimethyl silicone oil Q7-9120 with the viscosity of 12500cst, 12% of dimethyl silicone oil TI-1050 with the viscosity of 100000cst, 40% of organic silicon elastomer TI-3021 with the viscosity of 300000cst, 16% of organic silicon resin TI-7021 and 3% of tetrahexylDecyl alcohol ascorbic acid ester, 17% viscosity 700mm2Glycerol monostearate in/s.
The preparation method of the multifunctional silicone gel dressing, as shown in fig. 1, comprises the following steps:
(1) weighing all raw materials;
(2) firstly, adding 12g of dimethyl silicone oil Q7-9120, 12g of dimethyl silicone oil TI-1050, 40g of organic silicon elastomer TI-3021, 16g of organic silicon resin TI-7021 and 17g of glycerin monostearate into an oil phase reaction kettle, heating and stirring at 65 ℃, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform, wherein the stirring speed is 75 rmp;
(3) after stirring uniformly, cooling to room temperature, adding 3g of tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min at the stirring speed of 95rmp to obtain the dressing;
(4) filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
After the multifunctional silicone gel dressing is smeared, a protective layer is formed on the surface of the skin, the barrier function of the stratum corneum is recovered, the water loss through the epidermis is reduced, and the full hydration is favorable for softening, smoothing and flattening scars; the multifunctional silicone gel dressing coating forms a semi-permeable film within 3 minutes, so that the skin can breathe smoothly, physical, chemical and microorganism are effectively prevented from invading scar positions, itching is effectively relieved, fibroblasts can be normally generated in a protected environment, and abnormal scars are prevented; meanwhile, the composition can promote the formation of normal fibroblasts, bidirectionally regulate growth factors and promote the repair of scars.
More importantly, the multifunctional silicone gel dressing has good skin absorbability, so that the effective components can quickly take effect; can inhibit melanin generation, and has effects of whitening and brightening skin; can prevent lipid peroxidation and skin aging, and resist oxidation; can promote collagen synthesis and resist aging; can reduce cell or DNA damage caused by UV, and protect against ultraviolet rays. Among them, the effect of example 2 is the most excellent.
The tetrahexyl decyl ascorbate which is easily absorbed by skin, whitens and brightens the skin, resists oxidation, aging and ultraviolet rays is introduced into the silicone gel to prepare the multifunctional silicone gel dressing, and the preparation method is simple to operate, easy to control and suitable for industrial popularization and application.
The present invention is not limited to the above-mentioned embodiments, and based on the technical solutions disclosed in the present invention, those skilled in the art can make some substitutions and modifications to some technical features without creative efforts according to the disclosed technical contents, and these substitutions and modifications are all within the protection scope of the present patent.
Claims (8)
1. The multifunctional silicone gel dressing is characterized by comprising dimethicone Q7-9120, dimethicone TI-1050, a silicone elastomer TI-3021, silicone resin TI-7021, tetrahexyldecanol ascorbate and an emulsifier.
2. The multifunctional silicone gel dressing according to claim 1, wherein the formulation comprises, in weight percent: 12 percent of dimethyl silicone oil Q7-9120, 12 percent of dimethyl silicone oil TI-1050, 40 percent of organic silicon elastomer TI-3021, 16 percent of organic silicon resin TI-7021, 0.05-3 percent of tetrahexyldecanol ascorbic acid ester and 17-19.95 percent of emulsifier.
3. The multifunctional silicone gel dressing according to claims 1 and 2, wherein the viscosity of dimethicone Q7-9120 is 12500cst, the viscosity of dimethicone TI-1050 is 100000cst, the viscosity of silicone elastomer TI-3021 is 300000cst, and the viscosity of silicone resin TI-7021 is 700mm2/s。
4. The multifunctional silicone gel dressing according to claims 1 and 2, wherein the emulsifier is at least one of span 60, span 80, glyceryl monostearate, tween 60 or tween 80.
5. The preparation method of the multifunctional silicone gel dressing according to claims 1-4, characterized by comprising the following steps:
weighing all raw materials;
adding dimethyl silicone oil Q7-9120, dimethyl silicone oil TI-1050, an organic silicon elastomer TI-3021, an organic silicon resin TI-7021 and an emulsifier into an oil phase reaction kettle, heating and stirring, controlling the negative pressure of the reaction kettle to be-0.07 to-0.06 MPa, and stirring for 20min till the mixture is completely uniform;
after stirring uniformly, cooling to room temperature, adding tetrahexyldecyl ascorbate into the reaction kettle, and continuously stirring for 5-6min to obtain a dressing;
filling, inspecting, packaging, inspecting finished products, and warehousing qualified products.
6. The preparation method of the multifunctional silicone gel dressing according to claim 5, wherein in the step (2), the stirring temperature is 60-70 ℃.
7. The preparation method of the multifunctional silicone gel dressing according to claim 5, wherein in the step (2), the stirring speed is 60-80 rpm.
8. The preparation method of the multifunctional silicone gel dressing according to claim 5, wherein in the step (3), the stirring speed is 90-100 rpm.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168045A (en) * | 2015-09-07 | 2015-12-23 | 天津嘉氏堂科技有限公司 | Scar sun-screening and repairing silicon gel and preparation method thereof |
| CN107157986A (en) * | 2017-05-22 | 2017-09-15 | 天津嘉氏堂科技有限公司 | With the Silica hydrogel and preparation method for hiding the flaw, treating scar |
| FR3053247A1 (en) * | 2016-07-01 | 2018-01-05 | L'oreal | COSMETIC PROCESS FOR TREATING KERATINIC MATERIALS USING A COMPOSITION COMPRISING ASCORBIC ACID |
| CN110121368A (en) * | 2016-12-28 | 2019-08-13 | 株式会社界优维 | Silicon resin composition, preparation method and the treating acne agent comprising it |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
-
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- 2020-07-21 CN CN202010701501.8A patent/CN113952502A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168045A (en) * | 2015-09-07 | 2015-12-23 | 天津嘉氏堂科技有限公司 | Scar sun-screening and repairing silicon gel and preparation method thereof |
| FR3053247A1 (en) * | 2016-07-01 | 2018-01-05 | L'oreal | COSMETIC PROCESS FOR TREATING KERATINIC MATERIALS USING A COMPOSITION COMPRISING ASCORBIC ACID |
| CN110121368A (en) * | 2016-12-28 | 2019-08-13 | 株式会社界优维 | Silicon resin composition, preparation method and the treating acne agent comprising it |
| CN107157986A (en) * | 2017-05-22 | 2017-09-15 | 天津嘉氏堂科技有限公司 | With the Silica hydrogel and preparation method for hiding the flaw, treating scar |
| CN110227176A (en) * | 2018-03-05 | 2019-09-13 | 江苏昌吉永生物科技股份有限公司 | Scar eliminating silicone gel dressing and preparation method thereof |
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