CN112354005B - Dressing for promoting healing of burn and scald wound surfaces and preparation method thereof - Google Patents
Dressing for promoting healing of burn and scald wound surfaces and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0014—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
Abstract
The invention discloses a dressing for promoting healing of burn and scald wound surfaces, which comprises the following raw materials in parts by weight: 17-23 parts of polyvinylpyrrolidone, 2-8 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 5-10 parts of glutathione, 0.5-0.8 part of chlorella extract, 0.3-0.5 part of levolactic acid, 0.5-1.2 parts of asiaticoside, 0.4-0.8 part of inositol nicotinate, 0.5-1 part of hydroxyethyl urea, 0.35-0.7 part of laurocapram, 1.5-3 parts of film forming agent, 2-5 parts of borneol, 1-4 parts of hydrogenated lecithin and 40-50 parts of purified water. The dressing provided by the invention takes polyvinylpyrrolidone as a matrix, and caffeic acid-4-3-hydroxypropyl morpholine ester and glutathione are added to promote the rapid healing of burn and scald wound surfaces. The chlorella extract and the L-lactic acid can regulate and control the synthesis of collagen at the wound surface, inositol nicotinate can relieve edema at the wound surface of burn and scald, and asiaticoside and hydroxyethyl urea avoid the adhesion of the dressing and the wound surface to damage the new tissue. The invention also provides a preparation method of the dressing for promoting the healing of the burn and scald wound, and the preparation process is simple and convenient, is easy to operate and is convenient for commercial production and application.
Description
Technical Field
The invention relates to the field of medical dressings, in particular to a dressing for promoting healing of burn and scald wound surfaces and a preparation method thereof.
Background
Burn and scald are injuries encountered in work and life of people, in real life, the phenomenon of burn and scald happens occasionally, after the burn and scald occur, the skin of the burn and scald part turns red and blisters, and the edema can be festered seriously. The wound surface is improperly treated, scars are often formed, the appearance is affected, and even physical and psychological damage of the whole body is caused. Generally, burn and scald ointment or dressing is applied to the wound surface. The medical dressing is a medical material for temporarily covering the surfaces of various burn wounds and scald wounds, can prevent the wounds from being affected by bacterial infection and other external factors, and plays a role in protecting the wounds and the wound surfaces. Conventional dressings are generally a gel-like substance that is applied to a burn wound. The wound surface can be isolated from the outside, tissue fluid exuded from the wound surface can be absorbed in time, bacteria, fungi and viruses are isolated, infection is controlled, and wound surface healing is promoted. However, the current medical dressing has a plurality of problems in the using process.
Wound healing is a complex process, but the general dressing does not have the function of promoting wound healing. The wound healing agent can not effectively promote wound healing in the using process, leads to long course of disease of patients, increases the burden of the patients, is easy to generate scars and influence the beauty of skin, or is easy to adhere to the wound to cause secondary wound, damages new tissues when being uncovered, and brings great pain to the patients. A great amount of various burn and scald dressings emerge in the market at present, such as animal collagen, chitosan and hyaluronic acid which are common burn and scald dressing raw materials, and the prepared burn and scald dressings can not well solve the problems.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide the dressing for promoting the healing of the burn and scald wound surface, effectively promoting the rapid healing of the wound surface and avoiding the formation of serious scar tissues.
The invention also aims to provide a preparation method of the dressing for promoting the healing of the burn and scald wound.
One of the purposes of the invention is realized by adopting the following technical scheme:
a dressing for promoting healing of burn and scald wounds comprises the following raw materials in parts by weight: 17-23 parts of polyvinylpyrrolidone, 2-8 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 5-10 parts of glutathione, 0.5-0.8 part of chlorella extract, 0.3-0.5 part of levolactic acid, 0.5-1.2 parts of asiaticoside, 0.4-0.8 part of inositol nicotinate, 0.5-1 part of hydroxyethyl urea, 0.35-0.7 part of laurocapram, 1.5-3 parts of film forming agent, 2-5 parts of borneol, 1-4 parts of hydrogenated lecithin and 40-50 parts of purified water.
Further, the feed comprises the following raw materials in parts by weight: 20 parts of polyvinylpyrrolidone, 5 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 7 parts of glutathione, 0.7 part of chlorella extract, 0.2 part of levolactic acid, 1 part of asiaticoside, 0.5 part of inositol nicotinate, 0.8 part of hydroxyethyl urea, 0.5 part of laurocapram, 2 parts of film-forming agent, 3 parts of borneol, 3 parts of hydrogenated lecithin and 45 parts of purified water.
Further, the film forming agent is cellulose nitrate.
The second purpose of the invention is realized by adopting the following technical scheme:
the preparation method of the dressing for promoting the healing of the burn and scald wound comprises the following steps:
(1) taking purified water which accounts for half of the total consumption, and dissolving polyvinylpyrrolidone in the purified water with the temperature of more than or equal to 90 ℃;
(2) adding caffeic acid-4-3-hydroxypropyl morpholine ester, glutathione, Chlorella extract, L-lactic acid, asiaticoside, inositol nicotinate, hydroxyethyl urea, and hydrogenated lecithin into the rest purified water, and emulsifying;
(3) and (3) mixing the solution in the step (1) and the components in the step (2), adding laurocapram, a film forming agent and borneol, stirring and fully mixing, and sterilizing to obtain the product.
Further, in the step (2), emulsification is carried out at the temperature of 40-50 ℃ and the stirring speed of 50-100 r/min.
Further, the stirring speed in the step (3) is 100-.
Further, the product is obtained by irradiation sterilization in the step (3).
Compared with the prior art, the invention has the beneficial effects that:
1. the invention provides a dressing for promoting healing of burn and scald wound surfaces, which is a liquid dressing, wherein polyvinylpyrrolidone is used as a matrix, caffeic acid-4-3-hydroxypropyl morpholine ester and glutathione are added, wherein the caffeic acid-4-3-hydroxypropyl morpholine ester is beneficial to improving the repair capability of the wound surfaces, the glutathione is beneficial to keeping normal immunity of organisms, and the two components are synergistic to promote rapid scabbing and healing of the burn and scald wound surfaces.
2. The dressing also comprises chlorella extract, levolactic acid and inositol nicotinate, wherein the chlorella extract and the levolactic acid can regulate and control the synthesis of collagen at the wound surface, are beneficial to wound healing and simultaneously avoid the formation of serious scars at the wound surface; inositol nicotinate is helpful for reducing abnormal permeability of blood vessels at the wound surface, relieving edema at the wound surface of burn and scald, and promoting wound surface healing.
3. The asiaticoside and the hydroxyethyl urea are added into the dressing, so that the stimulation of the prepared liquid dressing to the burn and scald wound surface is reduced, the wound surface adhesion and the injury of new tissues are avoided, the pain of a patient is relieved, and the rapid healing of the wound surface is facilitated.
4. The dressing disclosed by the invention is added with laurocapram, so that the permeation effect of the dressing is improved, and the drug effect is better exerted. The film forming agent is added to ensure that the wound surface is in an aseptic environment, and the possible pollution caused by the external environment is avoided.
5. The invention also provides a preparation method of the dressing for promoting the healing of the burn and scald wound, and the preparation process is simple and convenient, is easy to operate and is convenient for commercial production and application.
Detailed Description
The present invention is further described below with reference to specific embodiments, and it should be noted that, without conflict, any combination between the embodiments or technical features described below may form a new embodiment.
Example 1
A dressing for promoting healing of burn and scald wound surfaces comprises the following raw materials in parts by weight: 20 parts of polyvinylpyrrolidone, 5 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 7 parts of glutathione, 0.7 part of chlorella extract, 0.2 part of levolactic acid, 1 part of asiaticoside, 0.5 part of inositol nicotinate, 0.8 part of hydroxyethyl urea, 0.5 part of laurocapram, 2 parts of cellulose nitrate, 3 parts of borneol, 3 parts of hydrogenated lecithin and 45 parts of purified water.
The preparation method of the dressing for promoting the healing of the burn and scald wound comprises the following steps:
(1) taking purified water which accounts for half of the total consumption, and dissolving polyvinylpyrrolidone in the purified water with the temperature of more than or equal to 90 ℃;
(2) adding caffeic acid-4-3-hydroxypropyl morpholine ester, glutathione, Chlorella extract, L-lactic acid, asiaticoside, inositol nicotinate, hydroxyethyl urea, and hydrogenated lecithin into the rest purified water, and emulsifying at 45 deg.C and stirring at 80 r/min;
(3) mixing the solution in the step (1) and the components in the step (2), adding laurocapram, a film forming agent and borneol, fully mixing for 40min under the condition that the stirring speed is 120r/min, and performing irradiation sterilization treatment to obtain the product.
Example 2
A dressing for promoting healing of burn and scald wound surfaces comprises the following raw materials in parts by weight: 17 parts of polyvinylpyrrolidone, 2 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 5 parts of glutathione, 0.5 part of chlorella extract, 0.3 part of levolactic acid, 0.5 part of asiaticoside, 0.4 part of inositol nicotinate, 0.5 part of hydroxyethyl urea, 0.35 part of laurocapram, 1.5 parts of cellulose nitrate, 2 parts of borneol, 1 part of hydrogenated lecithin and 40 parts of purified water.
The preparation method of the dressing for promoting the healing of the burn and scald wound comprises the following steps:
(1) taking purified water which accounts for half of the total consumption, and dissolving polyvinylpyrrolidone in the purified water with the temperature of more than or equal to 90 ℃;
(2) adding caffeic acid-4-3-hydroxypropyl morpholine ester, glutathione, Chlorella extract, L-lactic acid, asiaticoside, inositol nicotinate, hydroxyethyl urea, and hydrogenated lecithin into the rest purified water, and emulsifying at 40 deg.C and stirring at 50 r/min;
(3) mixing the solution in the step (1) and the components in the step (2), adding laurocapram, a film forming agent and borneol, fully mixing for 30min under the condition that the stirring speed is 100r/min, and performing irradiation sterilization treatment to obtain the product.
Example 3
A dressing for promoting healing of burn and scald wound surfaces comprises the following raw materials in parts by weight: 23 parts of polyvinylpyrrolidone, 8 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 10 parts of glutathione, 0.8 part of chlorella extract, 0.5 part of levolactic acid, 1.2 parts of asiaticoside, 0.8 part of inositol nicotinate, 1 part of hydroxyethyl, 0.7 part of laurocapram, 3 parts of cellulose nitrate, 5 parts of borneol, 4 parts of hydrogenated lecithin and 50 parts of purified water.
The preparation method of the dressing for promoting the healing of the burn and scald wound comprises the following steps:
(1) taking purified water which accounts for half of the total consumption, and dissolving polyvinylpyrrolidone in the purified water with the temperature of more than or equal to 90 ℃;
(2) adding caffeic acid-4-3-hydroxypropyl morpholine ester, glutathione, Chlorella extract, L-lactic acid, asiaticoside, inositol nicotinate, hydroxyethyl urea, and hydrogenated lecithin into the rest purified water, and emulsifying at 50 deg.C and stirring speed of 100 r/min;
(3) mixing the solution in the step (1) and the components in the step (2), adding laurocapram, a film forming agent and borneol, fully mixing for 60min under the condition that the stirring speed is 150r/min, and performing irradiation sterilization treatment to obtain the product.
Comparative example 1
Comparative example 1 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: caffeic acid-4-3-hydroxypropyl morpholine ester was omitted and the procedure in example 1 was repeated.
Comparative example 2
Comparative example 2 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: glutathione was omitted and the procedure was as in example 1.
Comparative example 3
Comparative example 3 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: caffeic acid-4-3-hydroxypropyl morpholine ester was omitted, and the amount of glutathione was adjusted to 12 parts, and the rest was the same as in example 1.
Comparative example 4
Comparative example 4 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: glutathione was omitted, and the amount of caffeic acid-4-3-hydroxypropyl morpholine ester was adjusted to 12 parts, and the rest was the same as in example 1.
Comparative example 5
Comparative example 5 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: chlorella extract was omitted and the procedure was as in example 1.
Comparative example 6
Comparative example 6 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: the L-lactic acid was omitted and the procedure was as in example 1.
Comparative example 7
Comparative example 7 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: inositol nicotinate was omitted and the procedure was as in example 1.
Comparative example 8
Comparative example 8 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: asiaticoside is omitted and the rest is the same as in example 1.
Comparative example 9
Comparative example 9 provides a dressing for promoting healing of a burn and scald wound, which is different from example 1 in that: the hydroxyethyl urea was omitted and the procedure was as in example 1.
Comparative example 10
Comparative example 10 provides a dressing for promoting healing of a burn and scald wound, which differs from example 1 in that: hydroxyethyl urea was omitted, and the amount of asiaticoside used was adjusted to 1.8 parts, all the other things being equal to example 1.
Selecting 110 SD rats, each half of male and female, randomly dividing into 11 groups, and depilating with depilatory (10% sodium sulfide) 24 hr before experiment to remove hair from the back of the rats with depilatory area of about 20cm2After ether anesthesia, the melted paraffin is dripped to a depilatory part to manufacture a II-degree burn and scald model of the skin on the back of the rat. The wound sites were coated with the dressings of example 1 and comparative examples 1 to 10, respectively, uniformly and each time, with a thickness of about 3mm, and the sites were bandaged with sterile gauze, administered twice a day, once in the morning and evening, and administered for 14 days continuously, and the scab areas of the wound sites of 7d and 14d were counted, respectively, and the results are shown in table 1.
TABLE 1
| Group of | Healing area 7d (cm)2） | Healing area of 14d (cm)2） |
| Example 1 | 11.25 | 18.79 |
| Comparative example 1 | 4.31 | 8.84 |
| Comparative example 2 | 5.23 | 10.64 |
| Comparative example 3 | 5.55 | 10.96 |
| Comparative example 4 | 6.17 | 11.85 |
| Comparative example 5 | 8.07 | 14.19 |
| Comparative example 6 | 8.20 | 14.35 |
| Comparative example 7 | 7.63 | 13.59 |
| Comparative example 8 | 7.94 | 13.97 |
| Comparative example 9 | 8.15 | 14.59 |
| Comparative example 10 | 8.24 | 14.70 |
It can be seen from table 1 that the rate of wound healing in rats in example 1 is higher than that in comparative examples 1 to 10. In comparative examples 1 to 4, one component of caffeic acid-4-3-hydroxypropyl morpholine ester and glutathione is omitted, or the dosage of the rest component is adjusted after one component is omitted, as can be seen from table 1, the healing capacity of the dressing after component adjustment on the wound surface is reduced, the healing area is far smaller than that of example 1 when the dressing is used at 7d and 14d, and the results show that caffeic acid-4-3-hydroxypropyl morpholine ester in the liquid dressing provided by the invention is helpful for improving the repair capacity of the wound surface, glutathione is helpful for keeping the normal immunity of an organism, and the two components cooperate to promote the rapid healing of the wound surface of burn and scald.
In comparative examples 5 to 7, one of chlorella extract, lactic acid and inositol nicotinate is omitted, and the scab healing area is reduced to a certain extent compared with that in example 1, because the chlorella extract and lactic acid can regulate and control the synthesis of collagen at the wound, the wound healing is facilitated, and inositol nicotinate is helpful for reducing the permeability abnormality of blood vessels at the wound, relieving the edema at the wound of burn and scald, and promoting the scab healing of the wound.
In comparative examples 8 to 10, one of asiaticoside and hydroxyethyl urea was omitted, or the dosage of asiaticoside was adjusted after the hydroxyethyl urea was omitted, and the obtained dressings all had a certain healing promoting effect after being applied to the wound on the back of rats, but the scab healing area was reduced to some extent compared with example 1, because the inventive dressings reduce irritation of the prepared liquid dressings to the burned and scalded wound by adding asiaticoside and hydroxyethyl urea, and simultaneously avoid adhesion of the dressings and the wound, which contributed to rapid healing of the wound.
4 rats of 14d each used in example 1 and comparative example 7 were sacrificed after anesthesia, the skin of the wound area was taken, the wet weight and dry weight of the skin were weighed, and the moisture content of the wound area was calculated: wound moisture content = skin wet weight-skin dry weight, results are shown in table 2.
TABLE 2
| Group of | Moisture content of wound surface (mg) |
| Example 1 | 0.104 |
| Comparative example 7 | 0.119 |
As shown in Table 2, the moisture content of the wound surface in the example 1 is lower than that of the wound surface in the comparative example 7, which shows that the inositol nicotinate in the dressing of the invention is helpful for reducing the abnormal permeability of blood vessels at the wound surface and relieving edema at the wound surface of burn and scald.
The remaining rats of example 1 and the rats of each comparative example were continuously administered to heal the wound, and the scar proliferation index of each group was calculated from 6 rats of example 1 and 6 rats of comparative examples 5 to 6, respectively, according to the following formula: scar hyperplasia index = the vertical height of the apex of the scar prominence to the subcutaneous muscle tissue/the vertical height of the normal skin surface around the scar to the subcutaneous muscle tissue.
Scar skin tissue blocks at the wound surface are taken and placed in 10% formaldehyde solution for fixation for 24h, dehydration and embedding are carried out to prepare paraffin sections, fixing is carried out by adopting 4% paraformaldehyde, the vertical height from the highest point of scar prominence to subcutaneous muscle tissue and the vertical height from the normal skin surface around the scar to the subcutaneous muscle tissue are measured under an optical microscope, and scar hyperplasia index is calculated, wherein the results are shown in table 3.
TABLE 3
| Group of | Index of scar hyperplasia |
| Example 1 | 1.06 |
| Comparative example 5 | 1.79 |
| Comparative example 6 | 1.94 |
From table 3, the scar proliferation index of example 1 is lower than that of comparative examples 5 and 6, which shows that the dressing of the invention is added with chlorella extract and levolactic acid, and by regulating and controlling the synthesis of collagen at the wound surface, the severe scar at the wound surface healing part is avoided, the scar proliferation index is effectively reduced, and the skin flatness after the wound surface healing is improved.
In conclusion, the liquid dressing provided by the invention avoids the adhesion between the dressing and the wound surface and relieves the wound surface edema through the synergistic effect of the components, and simultaneously avoids the formation of serious scars at the wound surface, thereby affecting the beauty of the skin, effectively improving the healing speed of the wound surface, relieving the pain of patients and having good clinical application prospect.
The above embodiments are only preferred embodiments of the present invention, and the protection scope of the present invention is not limited thereby, and any insubstantial changes and substitutions made by those skilled in the art based on the present invention are within the protection scope of the present invention.
Claims (7)
1. The dressing for promoting the healing of the burn and scald wound surface is characterized by comprising the following raw materials in parts by weight: 17-23 parts of polyvinylpyrrolidone, 2-8 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 5-10 parts of glutathione, 0.5-0.8 part of chlorella extract, 0.3-0.5 part of levolactic acid, 0.5-1.2 parts of asiaticoside, 0.4-0.8 part of inositol nicotinate, 0.5-1 part of hydroxyethyl urea, 0.35-0.7 part of laurocapram, 1.5-3 parts of film forming agent, 2-5 parts of borneol, 1-4 parts of hydrogenated lecithin and 40-50 parts of purified water.
2. The dressing for promoting healing of burn and scald wound surfaces according to claim 1 is characterized by comprising the following raw materials in parts by weight: 20 parts of polyvinylpyrrolidone, 5 parts of caffeic acid-4-3-hydroxypropyl morpholine ester, 7 parts of glutathione, 0.7 part of chlorella extract, 0.2 part of levolactic acid, 1 part of asiaticoside, 0.5 part of inositol nicotinate, 0.8 part of hydroxyethyl urea, 0.5 part of laurocapram, 2 parts of film-forming agent, 3 parts of borneol, 3 parts of hydrogenated lecithin and 45 parts of purified water.
3. The dressing for promoting healing of burn and scald wound surfaces according to claim 1 or 2, wherein the film forming agent is cellulose nitrate.
4. The preparation method of the dressing for promoting healing of burn and scald wound surfaces as claimed in any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) taking purified water which accounts for half of the total consumption, and dissolving polyvinylpyrrolidone in the purified water with the temperature of more than or equal to 90 ℃;
(2) adding caffeic acid-4-3-hydroxypropyl morpholine ester, glutathione, Chlorella extract, L-lactic acid, asiaticoside, inositol nicotinate, hydroxyethyl urea, and hydrogenated lecithin into the rest purified water, and emulsifying;
(3) and (3) mixing the solution in the step (1) and the components in the step (2), adding laurocapram, a film forming agent and borneol, stirring and fully mixing, and sterilizing to obtain the product.
5. The preparation method of the dressing for promoting healing of burn and scald wound surfaces according to claim 4, wherein in the step (2), emulsification is carried out at a temperature of 40-50 ℃ and a stirring speed of 50-100 r/min.
6. The method for preparing the dressing for promoting wound healing of burns and scalds according to claim 4, wherein the stirring speed in the step (3) is 100-150r/min, and the stirring time is 30-60 min.
7. The preparation method of the dressing for promoting healing of burn and scald wound surfaces according to claim 4, wherein the product is obtained by irradiation sterilization in the step (3).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011254990.3A CN112354005B (en) | 2020-11-11 | 2020-11-11 | Dressing for promoting healing of burn and scald wound surfaces and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011254990.3A CN112354005B (en) | 2020-11-11 | 2020-11-11 | Dressing for promoting healing of burn and scald wound surfaces and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112354005A CN112354005A (en) | 2021-02-12 |
| CN112354005B true CN112354005B (en) | 2021-07-27 |
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| CN115501125A (en) * | 2022-10-20 | 2022-12-23 | 澳门科技大学 | H for repairing skin lesions 2 S donor gel and H 2 Preparation method of S donor gel |
| CN115581798B (en) * | 2022-11-01 | 2023-06-23 | 珠海市雅莎医疗器械有限公司 | Liquid wound dressing for improving dark complexion and preparation method thereof |
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