CN105853252B - A kind of temperature-sensitive hydrogel and preparation method thereof for skin thermal damage - Google Patents
A kind of temperature-sensitive hydrogel and preparation method thereof for skin thermal damage Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/55—Phosphorus compounds
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- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The present invention relates to aesthetic restorative materials, specifically disclose a kind of temperature-sensitive hydrogel and preparation method thereof for skin thermal damage.The temperature-sensitive hydrogel includes following raw material components: chitosan, Sodium Hyaluronate, Geniposide, arbutin, barbaloin, menthol, remaining is distilled water.And preparation method thereof.Preparation method is, firstly, chitosan, Sodium Hyaluronate and Geniposide are mixed under the conditions of 4 DEG C of constant temperature, to form gel precursors mixture；Then, arbutin, barbaloin, menthol and distilled water are sequentially added in gel precursors mixture, stir evenly to get.The temperature-sensitive hydrogel has the advantage that (1) continued down；(2) moisturizing water lock is good, and use is more comfortable；(3) usable floor area, position are more flexible；(4) having improves the discomforts such as inflammatory reaction, scorching hot, tight, pain, promotes the superperformance of skin repair.
Description
Technical field
The present invention relates to aesthetic restorative materials, and in particular to a kind of temperature-sensitive hydrogel and its preparation for skin thermal damage
Method.
Background technique
In daily life, almost everyone live through skin thermal damage (such as sunburn or laser operation after it is non-selective
Thermal damage).Wherein sunburn is most common, often on the skin of exposure portion, occur the scarlet color spot of diffusivity, it is tight not
It is suitable, consciously burn or the symptoms such as tingle.Sunburn mainly takes local treatment, with cooling, moisturizing, anti-inflammatory, pacifies, relieves pain and be
Principle.After sunburn, people frequently with wet towel cold compress or after-sun recovery class product (such as moisturizing, repairs facial mask at whitening) into
The improvement of row malaise symptoms.
The skin thermal damage of the postoperative generation of laser beautifying is similar to after sunburn, is the most common complication in medical field.
Laser beautifying is the laser pulse using high-energy, for the treatment such as whitening, smoothing wrinkle, depilation, acne, black mole, senile plaque, still
Laser beautifying art can bring non-selective thermal damage simultaneously to therapentic part, destroy complete epidermal structure, and it is anti-to generate inflammation
It answers, shows as user's therapentic part (mostly based on face) and different degrees of burning heat sensation, picotement, pain, tight etc. occur
Malaise symptoms.Clinically to malaise symptoms after laser operation, common care method is main are as follows: 0.9% physiological saline cold wet compress
And the facial mask cold wet compress etc. of 4 DEG C of pre-coolings.
In conclusion thermal damage's cardinal symptom common in life is that damaged part burning heat sensation, tingling sensation, tight etc. occurs
Symptom.This requires ameliorative ways to be capable of providing continued down, a large amount of moisturizings, with the work for pacifying damage epidermis, anti-inflammatory analgetic
With.
According to above-mentioned requirements, at present to skin thermal damage, ameliorative way is broadly divided into cold wet compress and facial mask sticks two major classes,
But there are following three points deficiencies for current treatment method:
(1) continued down ability is poor.Since sunburn and laser beautifying postoperative skin temperature increase, continued down ability is needed
Alleviate the malaise symptoms such as burning heat sensation, picotement, the pain that damage location occurs.Clinically cooling effect is needed to hold time 30
Minute or more, it can just be obviously improved malaise symptoms.And the facial mask that cold wet compress at present is pre-chilled with 4 DEG C is several minutes to more than ten after sticking
Cooling effect can be played in minute, only cooling effect is obvious in a few minutes after use, extends cooling effect at any time and drops significantly
Low, the cooling duration is short, is unable to satisfy clinical requirement.
(2) liquid fluidity is big, water lock moisturizing is poor.Carrier of the facial mask as Essence, carrier fluid amount is limited, is sticking
Before, many Essences remain in facial mask bag, cause a large amount of losses, and also will appear facial mask dropping liquid, liquid at the initial stage that sticks
The problems such as flowing to lower skin because of gravity brings many inconvenience to user；And several minutes are being sticked to essence after more than ten minutes
It gradually lacks, loses replenishing water and preserving moisture effect；Extend as time go on, it is existing that facial mask even will appear different degrees of " back suction "
As aggravating therapentic part water shortage from user's skin intake water.
Clinic is solves the above-mentioned problem, frequently with the method that facial mask is replaced in midway, come solve to extend temperature fall time,
The problem of ensuring moistening effect.But therapeutic progresses can be made to increase in this way, made troubles to user.
(3) usable floor area, position are limited.Existing product is designed mainly for skin of face, and also Chang Qi in living
There is the thermal damage of skin in his position, such as: laser depilation, and the folds such as oxter are more, surface imperfection, and facial mask and skin affinity are not
Good, shape is limited, and the demand for not being able to satisfy various treatment positions, treating area greatly reduces operability.It cannot expire completely
The demand of sufficient user can not bring reliable comfortable improvement to user.
Therefore, to skin by needed after slight thermal damage one kind can continued down, water carrying capacity is sufficient and does not drip,
Usable floor area, position are more flexible, and having improves the discomforts such as inflammatory reaction, scorching hot, tight, pain, promote the special of skin repair
Industry care product.
Summary of the invention
Aiming at the problems existing in the prior art, it is an object of the present invention to provide a kind of for skin thermal damage's
Temperature-sensitive hydrogel, can continued down, water carrying capacity is sufficient and does not drip, and usable floor area, position are more flexible, have improve it is scorching
The discomforts such as disease reaction, scorching hot, tight, pain, and skin repair can be promoted.
It is another object of the present invention to provide a kind of preparation methods of temperature-sensitive hydrogel for skin thermal damage.
In order to achieve the above object, the present invention is achieved by the following scheme.
Technical solution one:
A kind of temperature-sensitive hydrogel for skin thermal damage, which is characterized in that including following raw material components: chitosan, thoroughly
Bright matter acid sodium, Geniposide, arbutin, barbaloin, menthol, remaining is distilled water.
Preferably, the raw material components weight percent are as follows: the chitosan of 0.01-0.05%, 0.005-0.04% it is saturating
Bright matter acid sodium, the Geniposide of 0.01-0.06%, the arbutin of 0.5-1%, the barbaloin of 0.005-0.02%, 0.005-
0.01g/ml menthol, remaining is distilled water.
Preferably, the raw material components further include sodium glycero-phosphate；The weight percent of the sodium glycero-phosphate is 0.1-
0.5%.
Preferably, the raw material components further include hEGF EGF；The weight of the hEGF EGF
Measuring percentage is 2 × 10-7-5×10-7%.
Technical solution two:
A kind of preparation method of the temperature-sensitive hydrogel for skin thermal damage, which comprises the following steps:
Step 1, under the conditions of 4 DEG C of constant temperature, chitosan, Sodium Hyaluronate and Geniposide are mixed, before forming gel
Body mixture；
Step 2, arbutin, barbaloin, menthol and distilled water are sequentially added in gel precursors mixture, stirring is equal
It is even to get.
Preferably, in step 1, when mixing, addition has sodium glycero-phosphate.
Preferably, in step 2, hEGF EGF has been sequentially added in gel precursors mixture.
Temperature-sensitive hydrogel for skin thermal damage of the invention, with substantive distinguishing features following prominent and significant effect
Fruit:
(1) continued down ability is improved.1. this product itself temperature in 4 DEG C of preservations, use is low, can reduce rapidly
The burning heat sensation in user affected part.2. this product realizes the phase transition process from colloidal sol to gel during user sticks simultaneously,
And can control this colloidal sol sluggish phase change, extend transformation time, which was endothermic process, it is ensured that at 30 minutes to 60 minutes
It is interior to provide continued down effect to user.3. being added to menthol ingredient in this product, when menthol topical application, there is rush
Into blood circulation, refrigerant and anti-inflammatory, it is antipruritic, analgesic the effects of, refrigerant comfortable feeling can be brought to patient in use.
By the improvement of above three aspect, common facial mask cooling duration short problem is breached, can be continued in a long time
Alleviate the discomforts such as skin burns, tight.
(2) liquid fluidity is reduced, water lock moisturizing ability is improved.1. temperature-sensitive hydrogel prepared by this product, joined
Biological cross-linker Geniposide, Geniposide are a kind of excellent natural biological crosslinking agents, can be with protein, collagen, gelatin and shell
The crosslinkings such as glycan make biomaterial, can guarantee hydrogel cross-linking effect, improve cross-link intensity and forming ability, make this production
Product reduce mobility at colloidality with good, compensate for the shortcomings that common facial mask is using initial stage dropping liquid.2. being added as guarantor
The Sodium Hyaluronate of aqua, Sodium Hyaluronate can form one layer of ventilative film in skin surface, keep skin smooth wet, can be with
Improve skin-nourishing metabolism, make skin it is tender, it is smooth, go wrinkle, increase elasticity, prevent aging, be good again while moisturizing
Skin penetration enhancer；Its hyalomitome molecule can carry 500 times or more of moisture, improve the moisturizing performance of this product, protect
The effect for continuing moisturizing in use is demonstrate,proved.By the use of both the above component, water lock and moisturizing energy are substantially increased
Power, at the same compensate for common facial mask using when the disadvantage dripped with moisturizing deficiency.Skin water shortage is effectively relieved and using discomfort etc.
Problem.
(3) usable floor area, position are flexible.The said goods are collosol state, can be taken in right amount by different area, different parts
With more more convenient than common facial mask.And its applicating property is good, can not stay dead angle, smears uniformly, compensates for existing product pair completely
The limitation of area and position.
(4) other the effective biotic components added in this product, can further enhance effect.For example, sodium glycero-phosphate
Addition, the converging network structure of chitosan can be made to be strengthened, compared with chitosan alone, drug release time is obviously prolonged；
HEGF EGF, arbutin can promote the reparation of epidermis, moisturize the skin；Arbutin, barbaloin and menthol can
Improve inflammatory reaction, relieve pain.
Specifically,
Sodium glycero-phosphate: temperature increases, and the hydrogen bond action on chitosan between amino and hydrone is more and more weaker and phosphoric acid
The effect of glycerol salt and hydrone is more and more stronger, when phosphoglycerol salt takes away the combination water on most amino, exposes
The amino come can promote molten with the amino or hydroxyl generation interaction of hydrogen bond formation gel network on other chitosan chains
Liquid changes rapidly to gel.
HEGF EGF: promote cell division, hence it is evident that accelerate beauty, after cosmetic operation and other skin traumas etc.
Wound healing, and keep the surface of a wound flat and smooth, abnormal pigmentary deposit on the skin trace is made to reduce or disappear and reduce pigmentation.Increase moisture content of skin, into
And increase skin elasticity, moisturizing.
Arbutin: feature is quickly alleviating pain, and anti-inflammatory power is strong, eliminates redness rapidly, healing is fast, preventing from scar.
Barbaloin: being the principle active component of aloe extract, a variety of amino acid that there is needed by human body to want, while aloe
Glycosides also has moisturizing, sun-proof, softening skin, anti-inflammatory anti-itch, and analgesic sterilizes, is antibacterial, decomposing the effects of toxin.
In conclusion compared with prior art, the present invention be have can continued down, water carrying capacity is sufficient and does not drip,
The more flexible advantage in usable floor area, position.Have simultaneously and promote skin repair ability, it is anti-to improve the inflammation that user occurs
It answers, is scorching hot, is tight, the special and professional care product that pain etc. is uncomfortable.
Detailed description of the invention
The present invention is described in further details in the following with reference to the drawings and specific embodiments.
Fig. 1 is the liquid schematic diagram of the temperature-sensitive hydrogel for skin thermal damage of the invention；
Fig. 2 is the gel schematic diagram of the temperature-sensitive hydrogel for skin thermal damage of the invention.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
It will be appreciated that the following example is merely to illustrate the present invention, and it is not construed as limiting the scope of the invention.
Embodiment 1:
Using 100g as total amount, 2g chitosan, 2g Sodium Hyaluronate, 28.8g sodium glycero-phosphate, the capital 3.5mg Buddhist nun are weighed respectively
It is flat, 3.8 × 10-2Ng hEGF EGF, 50mg arbutin, 1g barbaloin, 0.5g menthol, remaining is distilled water.
Step 1, under the conditions of 4 DEG C of constant temperature, chitosan, Sodium Hyaluronate, sodium glycero-phosphate and Geniposide are mixed,
Form gel precursors mixture；
Step 2, hEGF EGF, arbutin, barbaloin, peppermint are sequentially added in gel precursors mixture
Brain and distilled water are stirred evenly to get the temperature-sensitive hydrogel for skin thermal damage, and are stored under the conditions of 4 DEG C.
The temperature-sensitive hydrogel obtained for skin thermal damage, wherein including chitosan, the 0.02g/ml of 0.02g/ml
Sodium Hyaluronate, the sodium glycero-phosphate of 0.288g/ml, the Geniposide of 0.035mg/ml and 3.8 × 10-4People's table of ng/ml
The arbutin of skin growth factor EGF, 0.5mg/ml, the barbaloin of 0.01g/ml, 5mg/ml menthol, remaining is distilled water.
Embodiment 2:
Using 100g as total amount, 5g chitosan, 4g Sodium Hyaluronate, 50g sodium glycero-phosphate, 6mg Geniposide, 5 are weighed respectively
×10-2Ng hEGF EGF, 100mg arbutin, 2g barbaloin, 1g menthol, remaining is distilled water.
Step 1, under the conditions of 4 DEG C of constant temperature, chitosan, Sodium Hyaluronate, sodium glycero-phosphate and Geniposide are mixed,
Form gel precursors mixture；
Step 2, hEGF EGF, arbutin, barbaloin, peppermint are sequentially added in gel precursors mixture
Brain and distilled water are stirred evenly to get the temperature-sensitive hydrogel for skin thermal damage, and are stored under the conditions of 4 DEG C.
The temperature-sensitive hydrogel obtained for skin thermal damage, wherein saturating comprising 0.05g/ml chitosan, 0.04g/ml
Bright matter acid sodium, 0.5g/ml sodium glycero-phosphate, 0.06mg/ml Geniposide and 5 × 10-4Ng/ml hEGF EGF,
1mg/ml arbutin, 20mg/ml barbaloin, 10mg/ml menthol, remaining is distilled water.
Embodiment 3:
Using 100g as total amount, weigh respectively 1g chitosan, 0.5g Sodium Hyaluronate, 10g sodium glycero-phosphate, 1mg Geniposide,
2×10-2Ng hEGF EGF, 0.5g arbutin, 50mg barbaloin, 50mg menthol, remaining is distilled water.
Step 1, under the conditions of 4 DEG C of constant temperature, chitosan, Sodium Hyaluronate, sodium glycero-phosphate and Geniposide are mixed,
Form gel precursors mixture；
Step 2, hEGF EGF, arbutin, barbaloin, peppermint are sequentially added in gel precursors mixture
Brain and distilled water are stirred evenly to get the temperature-sensitive hydrogel for skin thermal damage, and are stored under the conditions of 4 DEG C.
The temperature-sensitive hydrogel obtained for skin thermal damage, wherein transparent comprising 0.01g/ml chitosan, 5mg/ml
Matter acid sodium, 0.1g/ml sodium glycero-phosphate, 0.01mg/ml Geniposide and 2 × 10-4Ng/ml hEGF EGF,
5mg/ml arbutin, 0.5mg/ml barbaloin, 0.5mg/ml menthol, remaining is distilled water.
In addition, the temperature-sensitive hydrogel for skin thermal damage of preparation forms hydrogel state at 37 DEG C.It can pass through
The ratio of chitosan and Sodium Hyaluronate is controlled, controls gel at 37 DEG C or so, so that gel formation time was at 30 minutes or more
Within 60 minutes.
As shown in Figure 1 and Figure 2, Fig. 1 is the liquid of hydrogel manufactured in the present embodiment, and Fig. 2 is water manufactured in the present embodiment
The gel of gel.
In use, by the temperature-sensitive hydrogel even application obtained for being used for skin thermal damage in the postoperative user of laser therapy
Rear or entire face are treated, guarantees about 2-3 millimeters of thickness；In coating process, overlay can absorb the portion of sticking
The temperature of position, gradually forms gel, gel integrally removes overlay after being formed completely, uses knot in 30 minutes to 60 minutes
Beam.
Although embodiment of the present invention is described above, the invention is not limited to above-mentioned specific implementations
Scheme, above-mentioned specific embodiment are only schematical, directiveness, rather than restrictive.The common skill of this field
Art personnel under the enlightenment of this specification, in the case where not departing from the range that the claims in the present invention are protected, can also do
A variety of form out, these belong to the column of protection of the invention.
Claims (5)
1. a kind of temperature-sensitive hydrogel for skin thermal damage, which is characterized in that including following raw material components: chitosan, transparent
Matter acid sodium, Geniposide, arbutin, barbaloin, menthol, remaining is distilled water；Wherein, the raw material components weight percent
Are as follows: the chitosan of 0.01-0.05%, the Sodium Hyaluronate of 0.005-0.04%, the Geniposide of 0.01-0.06%, 0.5-1%
Arbutin, the barbaloin of 0.005-0.02%, 0.005-0.01g/ml menthol, remaining is distilled water；The raw material components are also
Including sodium glycero-phosphate；The weight percent of the sodium glycero-phosphate is 0.1-0.5%.
2. the temperature-sensitive hydrogel according to claim 1 for skin thermal damage, which is characterized in that the raw material components are also
Including hEGF EGF.
3. the temperature-sensitive hydrogel according to claim 2 for skin thermal damage, which is characterized in that the human epidermal growth
The weight percent of factor EGF is 2 × 10-7-5×10-7%.
4. a kind of preparation method of the temperature-sensitive hydrogel described in claim 1 for skin thermal damage, which is characterized in that including
Following steps:
Step 1, under the conditions of 4 DEG C of constant temperature, chitosan, Sodium Hyaluronate and Geniposide are mixed, it is mixed to form gel precursors
Close object；When mixing, addition has sodium glycero-phosphate；
Step 2, arbutin, barbaloin, menthol and distilled water are sequentially added in gel precursors mixture, is stirred evenly, i.e.,
?.
5. the preparation method of the temperature-sensitive hydrogel according to claim 4 for skin thermal damage, which is characterized in that step
In 2, hEGF EGF is sequentially added in gel precursors mixture.
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| CN108354854A (en) * | 2018-04-24 | 2018-08-03 | 珀莱雅化妆品股份有限公司 | A kind of preparation method of the chitosan-based anti-acne hydrogel of temperature sensitive type used for cosmetic |
| CN108478485A (en) * | 2018-05-04 | 2018-09-04 | 邵立坤 | A kind of temperature-sensitive hydrogel facial mask and preparation method thereof |
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| CN104288828A (en) * | 2014-10-29 | 2015-01-21 | 广西信业生物技术有限公司 | Medical biological scar-inhibiting rhytidectomy dressing and preparation method thereof |
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2016
- 2016-03-31 CN CN201610201450.6A patent/CN105853252B/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101537205A (en) * | 2009-04-10 | 2009-09-23 | 暨南大学 | Degradable medical hemostatic non-viscous material and preparation method thereof |
| CN103027867A (en) * | 2011-09-30 | 2013-04-10 | 天津市中科健新材料技术有限公司 | Finishing liquor applied on wet tissue and available for after-sun makeup removal and repair |
| CN102698312A (en) * | 2012-05-24 | 2012-10-03 | 南方医科大学 | Skin wound repair hydrogel and preparation method thereof |
| CN103006687A (en) * | 2013-01-12 | 2013-04-03 | 何黎 | Functional preparation for laser postoperative skin regeneration and preparation method |
| CN104288828A (en) * | 2014-10-29 | 2015-01-21 | 广西信业生物技术有限公司 | Medical biological scar-inhibiting rhytidectomy dressing and preparation method thereof |
| CN104491915A (en) * | 2015-01-06 | 2015-04-08 | 穆向明 | Postoperative anti-adhesion medical dressing and preparation method thereof |
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