CN102698312A - Skin wound repair hydrogel and preparation method thereof - Google Patents
Skin wound repair hydrogel and preparation method thereof Download PDFInfo
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- CN102698312A CN102698312A CN2012101638716A CN201210163871A CN102698312A CN 102698312 A CN102698312 A CN 102698312A CN 2012101638716 A CN2012101638716 A CN 2012101638716A CN 201210163871 A CN201210163871 A CN 201210163871A CN 102698312 A CN102698312 A CN 102698312A
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- aloe
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Abstract
The invention discloses a skin wound repair hydrogel and a preparation method thereof. The skin wound repair hydrogel contains aloe original gel, chitosan, beta-sodium glycerophosphate and water; pH is 7.0-7.5. The preparation method mainly comprises the following steps: mixing 1-4% (w/v) chitosan solution and aloe original gel in volume ratio of 1: 1-2 at 2-10 degrees centigrade, then dropwise adding beta-sodium glycerophosphate aqueous solution, adjusting pH of solution to 7.0-7.5, and forming the hydrogel at 4-50 degrees centigrade. The skin wound repair hydrogel provided by the invention is capable of promoting generation of skin capillarity tubes, is beneficial to growth of tissue to protect nerve endings of wounds and reduce pain, is used for treating suppurative dermatosis, superficial dermatomycosis, skin trauma and ultraviolet dermatitis, and is featured with effects of diminishing inflammation, sterilizing, alleviating pain, absorbing heat, anti-swelling, softening skins, relieving pain and improving scars.
Description
Technical field
The present invention is specifically related to a kind of skin wound repair hydrogel and preparation method thereof.
Background technology
The dressing that in the skin trauma reparation, uses comprises traditional dressing and synthesis type dressing.Traditional dressing mainly is made up of materials such as cotton, lint, gauzes, is characterized in having good water absorption, thereby can keeps the drying of wound surface.But traditional dressing can not stop wound surface to be infected effectively.And traditional dressing is easy and planing surface sticks together, and makes the wound surface of firm recovery impaired during removal probably once more.The macromolecule membrane of synthesis type dressing has better elastic and breathability, and common used material has polyurethane, polyethylene, silicone rubber, politef etc.But because its hygroscopicity and water penetration are bad, often cause wound surface place formation hydrops and cause the breeding of antibacterial, so macromolecule membrane is used for epidermis injury more, be not suitable for for large-area skin lesion.And synthesis type adjuvant catabolite in vivo untoward reaction such as be prone to cause inflammation.
Summary of the invention
The object of the present invention is to provide a kind of skin wound repair hydrogel.
Another object of the present invention is to provide the method for preparing of above-mentioned skin wound repair hydrogel.
The technical scheme that the present invention adopted is:
A kind of skin wound repair hydrogel contains chitosan, Aloe virgin rubber, sodium and water.
A kind of skin wound repair hydrogel is calculated by mass percentage, contains chitosan 1.5～2%, Aloe virgin rubber 45～50%, and sodium 1～4%, surplus is a water.
The main component of Aloe virgin rubber is a polysaccharide, mainly contains mannose (60.73%), galactose (16.42%), glucose (9.16%), and Aloe glue has antiinflammatory, antibacterial, analgesia, heat absorption detumescence, softening skin, improves effects such as scar.Can be used to treat skin injury, ultraviolet dermatitis, dermatosis, dermatosis or anaphylaxis dermatosis due to the high low temperature.
Chitosan has the effect that promotes blood coagulation, can be used as hemorrhage.It also can be used for the Wound filling material, and have antibacterial, promote wound healing, absorb Wound exudate, be difficult for effect such as syneresis, but also can penetration air and moisture, promote wound healing.
A kind of method for preparing of skin wound repair hydrogel comprises the steps:
Under 2～10 ℃, after mix 1:1～2 by volume with the Aloe virgin rubber with 1～4% (w/v) chitosan solution, stir, dropwise add the sodium aqueous solution, the pH value of regulator solution is 7.0～7.5,4～50 ℃ and forms gel down.
Said Aloe virgin rubber is prepared by following method: get fresh aloe, after cleaning, sterilizing, stripping blade is got sarcocarp, and Mechanical Crushing is centrifugal, gets supernatant and is the Aloe virgin rubber.
Said Aloe is Aloe vulgaris, Aloe ferox Miller, Aloe vera L.var. chinensis(Haw.)Berg. or backsword formula Aloe.
Said sterilization is meant Aloe is placed irradiation 10～30min under the ultraviolet.
Said centrifugal concrete operations are: 5000～15000 commentaries on classics/min high speed centrifugations, 1～30min.
The chitosan solution of said 1%～4% (w/v) is prepared by following method: with the acetum dissolving chitosan of 0.5%～3% (v/v); Prepare the chitosan solution of 1%～4% (w/v); Getting the chitosan solution molecular weight of packing into is in the dialyzer of 1000-14000kDa; Place distilled water to dialyse under 4～37 ℃ 1～7 day, it is 1～4% (w/v) that the chitosan solution after the dialysis dilution is concentrated into concentration, and pH value is 6.0～6.5.
Said concentrating is meant at 50～70 ℃ of transpiring moistures.
Said sodium aqueous solution is prepared by following method: with distilled water preparation sodium aqueous solution, the membrane filtration sterilization with 0.22um obtains aseptic sodium aqueous solution.
The concentration of sodium aqueous solution is 40% (w/v).
Beneficial effect of the present invention is:Skin wound repair hydrogel of the present invention can promote the skin capillary tube to generate, and helps tissue growth, and protection wound surface teleneuron eases the pain.Can be used for treating suppurative dermatosis, superficial fungi dermatoses and skin injury, ultraviolet dermatitis, have antiinflammatory, antibacterial, analgesia, heat absorption detumescence, softening skin, pain relieving, improve the effect of scar.
The specific embodiment
Below in conjunction with embodiment the present invention is further described, but is not limited thereto.
Embodiment 1
1, the extraction of Aloe virgin rubber
Choose 10 years bright Aloe vulgariss of tissue regeneration promoting, after tap water cleans up, clean twice, place in sterile working's platform, ultra-vioket radiation sterilization 30min with distilled water.After sterilization is accomplished, get sarcocarp with the scalpel stripping blade, sarcocarp with the juice extractor fragmentation after, in the centrifuge tube of the 50mL that packs into, behind the 15000 commentaries on classics/min high speed centrifugation 5min, separation obtaining supernatant, is aseptic Aloe virgin rubber.
2, the preparation of chitosan solution
During the acetum that the 4g chitosan joins 100mL 3% (v/v) dissolved, 40 ℃ of following stirring and dissolving obtained separating the chitosan solution of 4% (w/v).Get the 50mL chitosan solution and pack in the 3000kDa dialyzer, under 4 ℃, place 2L distilled water dialysis 6 days, every other day change water.The chitosan solution that to dialyse then after the dilution places beaker, is placed on that transpiring moisture is concentrated to 50mL in 50 ℃ of baking ovens, and the pH value of the chitosan solution behind the dialysis purification is about 6.3.
3, the preparation of sodium solution
With the sodium of distilled water preparation 40% (w/v), the membrane filtration sterilization with 0.22um obtains aseptic sodium aqueous solution.
4, preparation gel
Under 4 ℃, 4% chitosan solution after the dialysis with after the Aloe virgin rubber mixes according to volume ratio 1:1, is stirred, dropwise add sodium then, between the pH value 7.2～7.4 of regulator solution.In 37 ℃ of (body temperature) 5min, just can form gel.
Method for using: gel is applied in the affected part gets final product.
Embodiment 2
1, the extraction of Aloe virgin rubber
Choose 10 years bright Aloe vulgariss of tissue regeneration promoting, after tap water cleans up, clean twice, place then in sterile working's platform, ultra-vioket radiation sterilization 30min with distilled water.After sterilization is accomplished, get sarcocarp with the scalpel stripping blade, sarcocarp with the juice extractor fragmentation after, in the centrifuge tube of the 50mL that packs into, behind the 15000 commentaries on classics/min high speed centrifugation 5min, separation obtaining supernatant, is aseptic Aloe virgin rubber.
2, the preparation of chitosan solution
During the acetum that the 4g chitosan joins 100mL 3% (v/v) dissolved, 40 ℃ of following stirring and dissolving obtained separating the chitosan solution of 4% (w/v).Get the 50mL chitosan solution and pack in the 3000kDa dialyzer, under 4 ℃, place 2L distilled water dialysis 6 days, every other day change water.The chitosan solution that to dialyse then after the dilution places beaker, is placed on that transpiring moisture is concentrated to 50mL in 50 ℃ of baking ovens, and the pH value of the chitosan solution behind the dialysis purification is about 6.3.
3, the preparation of sodium solution
With the sodium of distilled water preparation 40% (w/v), the membrane filtration sterilization with 0.22um obtains aseptic sodium aqueous solution.
4, preparation gel
Under 2 ℃, 4% chitosan solution after the dialysis with after the Aloe virgin rubber mixes according to volume ratio 1:1.7, is stirred, dropwise add sodium then, between the pH value 7.2～7.4 of regulator solution.In 37 ℃ of (body temperature) 5min, just can form gel.
Method for using: gel is applied in the affected part gets final product.
Embodiment 3
Choose 6 years bright Aloe vulgariss of tissue regeneration promoting, after tap water cleans up, clean twice, place then in sterile working's platform, ultra-vioket radiation sterilization 30min with distilled water.After sterilization is accomplished, get sarcocarp with the scalpel stripping blade, sarcocarp with the juice extractor fragmentation after, in the centrifuge tube of the 50mL that packs into, behind the 15000 commentaries on classics/min high speed centrifugation 5min, separation obtaining supernatant, is aseptic Aloe virgin rubber.
2, the preparation of chitosan solution
During the acetum that the 4g chitosan joins 100mL 3% (v/v) dissolved, 40 ℃ of following stirring and dissolving obtained separating the chitosan solution of 4% (w/v).Get the 50mL chitosan solution and pack in the 3000kDa dialyzer, under 4 ℃, place 2L distilled water dialysis 6 days, every other day change water.The chitosan solution that to dialyse then after the dilution places beaker, is placed on that transpiring moisture is concentrated to 50mL in 60 ℃ of baking ovens, and the pH value of the chitosan solution behind the dialysis purification is about 6.3.
3, the preparation of sodium solution
With the sodium of distilled water preparation 40% (w/v), the membrane filtration sterilization with 0.22um obtains aseptic sodium aqueous solution.
4, preparation gel
Under 10 ℃, 4% chitosan solution after the dialysis with after the Aloe virgin rubber mixes according to volume ratio 1:2, is stirred, dropwise add sodium then, between the pH value 7.2～7.4 of regulator solution.In 37 ℃ of (body temperature) 5min, just can form gel.
Method for using: gel is applied in the affected part gets final product.
Efficacy experiment:
Get 20 SD rats about 150g, be divided into experimental group 1,2,3 and blank control group at random, two groups of rat backs are done depilation and are handled; Behind the 75% alcohol disinfecting skin, respectively do the otch of a 1 * 1cm in the both sides, back, the blank group lets it heal voluntarily; The skin wound repair hydrogel of the embodiment of the invention 1～3 is smeared in experimental group wound bottom surface; Respectively at 3,7,14 days record wound healing rates.The result shows, smeared skin wound repair hydrogel of the present invention after, the healing rate of wound surface significantly improves (seeing table 1).
Above embodiment is merely and introduces preferred case of the present invention, and to those skilled in the art, any conspicuous variation and the improvement in the scope that does not deviate from spirit of the present invention, carried out all should be regarded as a part of the present invention.For example; The method for preparing of skin wound repair hydrogel of the present invention; Except can adopting the Aloe virgin rubber that from Aloe vulgaris, extracts, can also adopt Aloe kind, like the Aloe virgin rubber that extracts in Aloe ferox Miller, Aloe vera L.var. chinensis(Haw.)Berg. or the backsword formula Aloe from other; All can realize the object of the invention, fall in protection scope of the present invention.
Claims (10)
1. a skin wound repair hydrogel contains chitosan, Aloe virgin rubber, sodium and water.
2. skin wound repair hydrogel according to claim 1 is calculated by mass percentage, contains chitosan 1.5～2%, Aloe virgin rubber 45～50%, and sodium 1～4%, surplus is a water.
3. the method for preparing of a skin wound repair hydrogel comprises the steps:
Under 2～10 ℃, after mix 1:1～2 by volume with the Aloe virgin rubber with 1～4% (w/v) chitosan solution, stir, dropwise add the sodium aqueous solution, the pH value of regulator solution is 7.0～7.5,4～50 ℃ and forms gel down.
4. the method for preparing of skin wound repair hydrogel according to claim 3 is characterized in that, said Aloe virgin rubber is prepared by following method: get fresh aloe; After cleaning, sterilizing, stripping blade is got sarcocarp, Mechanical Crushing; Centrifugal, get supernatant and be the Aloe virgin rubber.
5. the method for preparing of skin wound repair hydrogel according to claim 3; It is characterized in that; The chitosan solution of said 1%～4% (w/v) is prepared by following method: with the acetum dissolving chitosan of 0.5%～3% (v/v); Prepare the chitosan solution of 1%～4% (w/v), getting the chitosan solution molecular weight of packing into is in the dialyzer of 1000-14000kDa, places distilled water to dialyse 1～7 day under 4～37 ℃; It is 1～4% (w/v) that chitosan solution after the dialysis dilution is concentrated into concentration, and pH value is 6.0～6.5.
6. the method for preparing of skin wound repair hydrogel according to claim 3; It is characterized in that; Said sodium aqueous solution is prepared by following method: with distilled water preparation sodium aqueous solution; Membrane filtration sterilization with 0.22um obtains aseptic sodium aqueous solution.
7. the method for preparing of skin wound repair hydrogel according to claim 4 is characterized in that, said Aloe is Aloe vulgaris, Aloe ferox Miller, Aloe vera L.var. chinensis(Haw.)Berg. or backsword formula Aloe.
8. the method for preparing of skin wound repair hydrogel according to claim 4 is characterized in that, said sterilization is meant Aloe is placed irradiation 10～30min under the ultraviolet.
9. the method for preparing of skin wound repair hydrogel according to claim 4 is characterized in that, said centrifugal concrete operations are: 5000～15000 commentaries on classics/min high speed centrifugations, 1～30min.
10. according to the method for preparing of claim 3 or 6 described skin wound repair hydrogels, it is characterized in that the concentration of sodium aqueous solution is 40% (w/v).
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| CN104623719A (en) * | 2015-02-03 | 2015-05-20 | 广东泰宝医疗科技股份有限公司 | Chitosan hydrogel dressing and preparation method of chitosan hydrogel dressing |
| CN105363064A (en) * | 2015-11-02 | 2016-03-02 | 石森林 | Compound aloe vera polysaccharide gel antiseptic dressing for treating burns |
| CN105381159A (en) * | 2015-11-02 | 2016-03-09 | 浙江中医药大学 | Compound aloe barbadensis polysaccharide topical gel used for treating burn |
| CN105853252A (en) * | 2016-03-31 | 2016-08-17 | 中国人民解放军第四军医大学 | Thermosensitive hydrogel for skin thermal damage and preparation method thereof |
| CN107349469A (en) * | 2017-07-22 | 2017-11-17 | 聊城大学 | The preparation method and application of tracheal strips wound repair temperature-sensitive hydrogel |
| CN110869062A (en) * | 2017-07-19 | 2020-03-06 | 贝拉英特拉大学 | Film for topical application in the treatment of skin lesions and method for obtaining and applying same |
| CN111420117A (en) * | 2020-03-31 | 2020-07-17 | 陕西朗泰生物科技有限公司 | Preparation method of gel containing stem cell exosomes for skin wound repair |
| CN112535761A (en) * | 2020-12-28 | 2021-03-23 | 苏州举健生物科技有限公司 | Antibacterial hemostatic healing-promoting gel, preparation method and application thereof |
| CN113171417A (en) * | 2021-04-26 | 2021-07-27 | 贵州扬生医用器材有限公司 | Wound surface disinfectant and preparation method and application thereof |
| CN114306720A (en) * | 2022-01-04 | 2022-04-12 | 武汉同向医疗器械有限公司 | Wound dressing containing aloe gel and preparation method thereof |
| CN115634251A (en) * | 2022-07-22 | 2023-01-24 | 河南稷道数字栽培研究院有限公司 | Preparation method of aloe gel externally applied medicine for wound |
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| CN104623719A (en) * | 2015-02-03 | 2015-05-20 | 广东泰宝医疗科技股份有限公司 | Chitosan hydrogel dressing and preparation method of chitosan hydrogel dressing |
| CN105363064B (en) * | 2015-11-02 | 2018-06-05 | 石森林 | A kind of compound aloe barbadensis Miller polysaccharide gel antiseptic dressing for treatment burn |
| CN105363064A (en) * | 2015-11-02 | 2016-03-02 | 石森林 | Compound aloe vera polysaccharide gel antiseptic dressing for treating burns |
| CN105381159A (en) * | 2015-11-02 | 2016-03-09 | 浙江中医药大学 | Compound aloe barbadensis polysaccharide topical gel used for treating burn |
| CN105381159B (en) * | 2015-11-02 | 2019-07-26 | 浙江中医药大学 | It is a kind of for treat burn compound aloe barbadensis Miller polysaccharide external-use gel |
| CN105853252B (en) * | 2016-03-31 | 2019-01-15 | 中国人民解放军第四军医大学 | A kind of temperature-sensitive hydrogel and preparation method thereof for skin thermal damage |
| CN105853252A (en) * | 2016-03-31 | 2016-08-17 | 中国人民解放军第四军医大学 | Thermosensitive hydrogel for skin thermal damage and preparation method thereof |
| CN110869062A (en) * | 2017-07-19 | 2020-03-06 | 贝拉英特拉大学 | Film for topical application in the treatment of skin lesions and method for obtaining and applying same |
| US11058712B2 (en) | 2017-07-19 | 2021-07-13 | Universidade Da Beira Interior | Film for topical application in the treatment of skin lesions and method of obtaining and applying same |
| CN107349469A (en) * | 2017-07-22 | 2017-11-17 | 聊城大学 | The preparation method and application of tracheal strips wound repair temperature-sensitive hydrogel |
| CN111420117A (en) * | 2020-03-31 | 2020-07-17 | 陕西朗泰生物科技有限公司 | Preparation method of gel containing stem cell exosomes for skin wound repair |
| CN112535761A (en) * | 2020-12-28 | 2021-03-23 | 苏州举健生物科技有限公司 | Antibacterial hemostatic healing-promoting gel, preparation method and application thereof |
| CN113171417A (en) * | 2021-04-26 | 2021-07-27 | 贵州扬生医用器材有限公司 | Wound surface disinfectant and preparation method and application thereof |
| CN114306720A (en) * | 2022-01-04 | 2022-04-12 | 武汉同向医疗器械有限公司 | Wound dressing containing aloe gel and preparation method thereof |
| CN115634251A (en) * | 2022-07-22 | 2023-01-24 | 河南稷道数字栽培研究院有限公司 | Preparation method of aloe gel externally applied medicine for wound |
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