CN106606798A - Medical hyaluronic acid bioremediation plaster and preparation method thereof - Google Patents
Medical hyaluronic acid bioremediation plaster and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention discloses a medical hyaluronic acid bioremediation plaster and a preparation method thereof; a hyaluronic acid raw liquid in the bioremediation plaster comprises the following components by the mass percentage: 0.001%-0.3% of a higher-molecular-weight hyaluronic acid, 0.001%-0.1% of a medium-molecular-weight hyaluronic acid, 0.001%-0.3% of an enzyme-digestion oligomeric hyaluronic acid, 0.01%-5% of butanediol, 1%-15% of glycerin, 0.001%-0.2% of dragosantol, 0.01%-1.5% of allantoin, 0.1%-0.8% of carbomer 980, 0.01%-0.6% of D-panthenol, 0.02%-1% of sodium hydroxide, 0.05%-5% of an aloe extract, 0.05%-3% of a licorice root extract, 0.001%-0.5% of methylparaben, and the balance purified water. The medical hyaluronic acid bioremediation plaster takes non-woven cloth or silk cloth as a substrate. The medical hyaluronic acid bioremediation plaster prepared from the hyaluronic acids with the high molecular weight, medium molecular weight and oligomeric molecular weight is applied in remediation and nursing of facial acne, eczematous dermatitis, and laser and photon rejuvenation postoperation, promotes wound surface healing, and achieves the effects of remediation and reconstruction of a skin barrier function.
Description
Technical field
The present invention relates to medical reparation field, and in particular to a kind of medical hyaluronic acid is biological prosthetic to be pasted and its preparation side
Method.
Background technology
Hyaluronic acid（Hyaluronic Acid, HA）For a kind of linear polysaccharide, by β -1,3- glucose acetamides（β-1,
3-N-acetylglucosamine）With β -1,4- gluconic acids（β-1,4-glucuronic acid）With β-Isosorbide-5-Nitrae glucosides key-shaped
Into repetition disaccharide unit, this disaccharides repetitive again with β -1,3 glycosidic bonds repeat connect, formed straight chain polymer polymer.
Hyaluronic acid can absorb the moisture of more than 500 times of relative self-molecules present amount, at the same can affect the transfer of cell, differentiation, growth,
Blood vessel transfer, immunological regulation and radicals scavenging etc..Additionally, hyaluronic acid does not have kind sex differernce, with extremely excellent life
Thing compatibility and biodegradability, in being widely used in medicine and skin care item.
Skin is the important storage vault of hyaluronic acid, while being also the important component of extracellular matrix, is maintaining skin
Form, 26S Proteasome Structure and Function aspect have important function.Almost all of tissue and liquid contain hyaluronic acid in human body, and machine
The body hyaluronic acid of more than half is enriched in epidermis and corium positioned at skin, and during skin wound healing, hyaluronic acid rises
Vital effect, is to reach one of material of wound after body injury earliest, combined with fibrinogen, in HA enzymes
The lower hydrolysis of effect, excites subsequent wound reparation until repairing completely.HA can also strengthen the effect of fibrin ferment in injury, make
For the catalyst that fibrin clot is formed.Monocytic pathology phagocytosis reaction can also be promoted simultaneously.Due to HA water conservations and hydrability
Can, by expanding intercellular space, promote signaling, bring up one and be suitable for inflammatory cell entrance and maintain its active ring
Border, exception, hyaluronic acid promotes the entrance of epidermal cell and sticks, and can also promote fibrocellular increment and migration.
The hyaluronic acid of different molecular weight has different expression ways during skin ultrastructure.Existing market product
Prepared by the hyaluronic acid of unimodal molecular weight mostly or the hyaluronic acid of several different molecular weights is arbitrarily arranged in pairs or groups, it is impossible to will be saturating
Barrier protection and repair maximization of the bright matter acid to skin.Molecular weight hyaluronic acid, the intermediate molecular weights such as Jing height of the present invention
The scientific matching of hyaluronic acid and digestion oligomerization hyaluronic acid, auxiliary in other palliative compositions, hyaluronic acid opposite is realized in perfection
The postoperative reparation of portion's acne, dermatitis and eczema, laser, photon delicate skin and nursing, promote wound healing, reach reconstruction skin
The effect of the barrier sexual function of skin.
The content of the invention
It is an object of the invention to provide a kind of biological prosthetic patch of medical hyaluronic acid for having a scientific matching, can eliminate skin
Skin inflammation, promotes wound healing, reaches the effect of the barrier sexual function of reconstruction skin.
To reach above-mentioned purpose, the present invention is employed the following technical solutions：
A kind of biological prosthetic patch of medical hyaluronic acid, including：The hyaluronic acid stoste that matrix is adsorbed with matrix.Wherein hyalomitome
Sour stoste includes the component of following percentage：The molecular weight hyaluronic acids such as 0.001%～0.3% height, decile in 0.001%～0.1%
Son amount hyaluronic acid, 0.001%～0.3% digestion oligomerization hyaluronic acid, 0.01%～5% butanediol, 1%～15% glycerine, 0.001%
～0.2% bisabolol, 0.01%～1.5% allantoin, 0.1%～0.8% Carbopol, 0.01%～0.6% D-pantothenyl aleohol, 0.02%
～1% NaOH, 0.05%～5% aloe extract, 0.05%～3% licorice root extract, 0.001%～0.5% methyl hydroxybenzoate,
Remaining is purified water.Its mesostroma is non-woven fabrics or silk fabric carrier.
The high molecular weight hyaluronic acid of the present invention has good lubricity and film forming, can be formed in skin surface
The netted hydration shell of gas, adjusts the water balance of skin and can effectively completely cut off the intrusion of the pathogen such as extraneous bacterial micro-organism；
There is intermediate molecular weight hyaluronic acid cell migration to act on, and hydrolyze in the presence of hyaluronidase, effectively facilitate tissue damage
Reparation；Digestion oligomerization hyaluronic acid can infiltrate into skin base layer, and moisturizing maintenance is provided from root, while removing excessive
Free radical, stimulate circulation, blood vessel hyperplasia and regulate and control the synthesis of collagen.The biological prosthetic patch of medical hyaluronic acid of the present invention
Using the scientific matching of high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion oligomerization hyaluronic acid, three association
Same-action, high molecular weight hyaluronic acid forms protecting film and provides wet environment, and intermediate molecular weight hyaluronic acid promotes cell
Migration and tissue damage reparation, digestion oligomerization hyaluronic acid is stimulated circulation, promotes granulation growth, accelerating wound healing energy
Power.
Butanediol is 1,3- dihydroxy butane, is one kind of polyalcohol, often makees NMF, because butanediol is that small molecule is protected
Wet composition, so water ratio very little is grabbed, while also there is certain bacteriostasis.
Glycerine is glycerine, as NMF, avoids periwound skin from suffering damage while sepage can be absorbed.
Bisabolol is a kind of composition in yellow chamomile, it is possible to provide good skin-friendliness, while with anti-inflammatory suppression
Bacterium acts on, and there is an optimum concentration, and validity is reduced on the contrary after optimum concentration.
Allantoin is 5- Allantoins, is that one kind is releived composition, can mitigate outside stimulus, improve medical hyalomitome
The skin-friendliness of sour biology maintenance patch, promotion cell growth.
Carbomer is polyacrylic resin, is common thickener.And Carbopol viscosity is higher, residual solvent is less,
Biocompatibility is more excellent.
D-pantothenyl aleohol is the NMF that can be penetrated deep into, and stimulates the growth of epithelial cell, promotes wound healing and play to disappear
Inflammation effect.
Aloe extract has skin whitening, moisturizing, antiallergy, the regeneration for promoting injury tissue and healing function.
Licorice root extract is the composition for having a medical value extracted from Radix Glycyrrhizae, and it has clearing heat and detoxicating, anti-inflammatory and anti-
Abnormal ability, can suitably alleviate allergic symptom of the only a few to hyaluronic acid autopath.
Methyl hydroxybenzoate is a kind of efficient germicide, heat-resist, and the growth to suppressing bacterial micro-organism has work well
With the holding time of the biological prosthetic patch of medical hyaluronic acid can be extended.
NaOH adjusts that medical hyaluronic acid is biological prosthetic to be labelled to skin optimal pH as antalkali.
Preferably, the hyaluronic acid stoste in the biological prosthetic patch of medical hyaluronic acid includes the component of following percentage：
The molecular weight hyaluronic acids such as 0.08% height, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3% fourth two
Alcohol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% NaOH,
0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
Preferably, the molecular weight of high molecular weight hyaluronic acid is more than 1800 kDa, preferably 2000 kDa；Medium molecule
The molecular weight of amount hyaluronic acid is 400 kDa～800 kDa, and preferably 680 kDa, the molecular weight of digestion oligomerization hyaluronic acid is less than
10 kDa, preferably 5600 Da.
Preferably, the matter of high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion oligomerization hyaluronic acid
Amount is than being 4:1:5.
Preferably, the matrix in the biological prosthetic patch of medical hyaluronic acid adopts non-woven fabrics or silk fabric for carrier.
Preferably, the biological prosthetic patch of medical hyaluronic acid adopts Co60 irradiation sterilizations.
Present invention also offers the preparation method of the biological prosthetic patch of medical hyaluronic acid, each distributed components and not can be made
Influence each other, the biological prosthetic patch stability of medical hyaluronic acid of preparation is optimum.
The preparation method of the biological prosthetic patch of above-mentioned medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Preferably, it is 5～7, preferably 6.2 that step 3 NaOH adjusts hyaluronic acid stoste pH value.
Compared with prior art, the invention has the beneficial effects as follows：
（1）Prepared using the scientific matching of equimolecular quantity hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid
Medical hyaluronic acid it is biological prosthetic patch particular for the postoperative reparation of face acnes, dermatitis and eczema, laser, photon delicate skin and shield
Reason, promotes wound healing, reaches effect of barrier sexual function of reconstruction skin etc.；
（2）Bisabolol and D-pantothenyl aleohol are added, diminish inflammation the factor, skin permeation deep layer, stimulate epithelial cell growth, promote wound
Mouth healing；
（3）Natural aloe extract and licorice root extract is added, the biological prosthetic patch of medical hyaluronic acid is at utmost played
Repair to skin, while reducing probability of the only a few patient to hyaluronic acid allergic symptom.
（4）Allantoin is added, the skin-friendliness of the biological prosthetic patch of medical hyaluronic acid is improve, mitigates environmental stimuli thing
Bring the skin irritatin caused by skin into.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.1% intermediate molecular weight hyaluronic acid, 2.9% butanediol, 8% glycerine, 0.05% is red
Bisabol, 0.1% allantoin, 0.2% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5%
Licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 800
kDa。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：High molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 2
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：0.1% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 2.0% butanediol, 8% glycerine, 0.05% red does not have
Medicine alcohol, 0.1% allantoin, 0.15% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5% is sweet
Grass roots extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of intermediate molecular weight hyaluronic acid is 680 kDa；The molecular weight of digestion oligomerization hyaluronic acid is 8000
Da。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：Intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 3
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.1% digestion oligomerization hyaluronic acid, 2.0% butanediol, 8% glycerine, 0.05% red does not have
Medicine alcohol, 0.1% allantoin, 0.2% Carbopol, 0.2% D-pantothenyl aleohol, 0.1% NaOH, 0.5% aloe extract, 0.5% is sweet
Grass roots extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600
Da。
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：High molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbopol are added to into appropriate purified water
In, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 4
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.08% height, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 5
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.1% height, 0.08% intermediate molecular weight hyaluronic acid, 0.02% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 8000 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 6
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.08% height, 0.1% intermediate molecular weight hyaluronic acid, 0.02% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 7
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.02% height, 0.08% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3%
Butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydroxide
Sodium, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
Embodiment 8
A kind of biological prosthetic patch of medical hyaluronic acid, the hyaluronic acid stoste that its matrix is adsorbed includes following mass percent
Component：The molecular weight hyaluronic acids such as 0.065% height, 0.065% intermediate molecular weight hyaluronic acid, 0.065% digestion oligomerization hyalomitome
Acid, 3% butanediol, 8% glycerine, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% hydrogen
Sodium oxide molybdena, 0.5% aloe extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
The molecular weight of high molecular weight hyaluronic acid is 2000 kDa；The molecular weight of intermediate molecular weight hyaluronic acid is 680
kDa；The molecular weight of digestion oligomerization hyaluronic acid is 5600 Da.
The preparation method of the biological prosthetic patch of medical hyaluronic acid, comprises the following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
The biological prosthetic patch of 1 medical hyaluronic acid is tested to laser operation white mouse wound healing effect
Take 15 Wistar big white mouse, body weight about 120g is randomly divided into after five groups and carried out back with 6.5% sodium sulfide solution and take off
Hair is processed, and depilation area is 2.5 cm × 2 cm, normal after distilled water flushing is clean to feed 12h.Laser is used after being anesthetized with ether
Beam carries out surface of a wound cutting along depilation position, and rate of cutting is 0.5m/min, causes laser beam postoperative wound.
Reference examples：With example 1, but it is not added with hyaluronic acid.
Medical hyaluronic acid prepared by embodiment 1, embodiment 2, embodiment 3 and embodiment 4 is biological prosthetic to stick on
Each mouse back is simultaneously wound with sterile bandage, and daily dressing once, observes the last healing time of the surface of a wound（With decrustation as final healing
Point）.The results are shown in Table 1.
The biological prosthetic patch of the different medical hyaluronic acids of table 1 is to white mouse wound healing effect after laser operation
Conclusion：（1）Embodiment 1, embodiment 2, embodiment 3, embodiment 4 are compared with control group, and healing time substantially shortens, and says
It is bright：Hyaluronic acid is obviously promoted wound healing.（2）Embodiment 1, embodiment 2, embodiment 3 are using two kinds of differences point
The hyaluronic acid of son amount, wound healing time is all more than 14 days, and digestion oligomerization hyaluronic acid and high equimolecular quantity is transparent
Matter acid accounting is higher, and wound healing time is shorter.（3）The healing time of embodiment 4 is foreshortened to 12 ± 1 days, shows three kinds of differences point
The hyaluronic acid synergy of son amount, to the wound healing best results after laser operation, the hyaluronic acid of high equimolecular quantity can
Wound moist environment is kept, while forming barrier film prevents outside contamination, and the hyaluronic acid of intermediate molecular weight can promote group
The reparation of damage is knitted, digestion oligomerization hyaluronic acid is permeable to skin base layer, further repair the impaired surface of a wound.
Test 2
Three kinds of hyaluronan molecule amounts are with the impact for comparing wound healing
15 facial mild acnes and the patient with light inflammation are chosen, wherein man 5, female 10, average age 25.5
Year.Being classified as surface of a wound degree in five groups, and five groups at random does not have significant difference to ensure that experimental result has contrast value.
The medical hyaluronic acid prepared in embodiment 4, embodiment 5, embodiment 6, embodiment 7 and embodiment 8 biological prosthetic is sticked
On acne surface, sooner or later respectively once, continuously stick more than two weeks until wound healing.Statistics wound healing time, the results are shown in Table
2。
2 three kinds of hyaluronan molecule amounts of table match somebody with somebody the Healing for comparing mild acne and carrying light inflammation patient
Conclusion：The healing effect with comparison acne of different molecular weight hyaluronic acid is different, when high equimolecular quantity and digestion oligomerization
When hyaluronic acid contents are higher, healing effect is optimal, and high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid and digestion are few
The mass ratio of poly- hyaluronic acid is 4:1:When 5, as long as acne healing time 10 ± 1 days.
Test 3
Regulating and controlling effect of the biological prosthetic patch of medical hyaluronic acid to scalding healing
Take 8 Wistar big white mouse, body weight about 120g, be randomly divided into after two groups carries out back depilation with 6.5% sodium sulfide solution
Process, depilation area is 2.5 cm × 2 cm, normal after distilled water flushing is clean to feed 12h.With 80 DEG C of water after being anesthetized with ether
Scald and process 15s, and ensure that scalding area does not have notable difference.
The medical hyaluronic acid of the preparation of Example 4 is biological prosthetic to stick on each mouse back and is twined with sterile bandage
Around daily dressing once, is continuously sticked two weeks, and by table 3 its average scalding area size is recorded（It is defined by scab forming time）.
Reference examples：With example 1, but it is not added with hyaluronic acid.
Conclusion：The biological prosthetic patch of medical hyaluronic acid substantially, quickly heals to minor scald healing effect with scald wound is promoted
Conjunction ability.
Claims (9)
1. the biological prosthetic patch of a kind of medical hyaluronic acid, it is characterised in that include：The hyaluronic acid that matrix is adsorbed with matrix is former
Liquid.
2. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that hyaluronic acid stoste include with
The component of lower percentage：The molecular weight hyaluronic acids such as 0.001%～0.3% height, 0.001%～0.1% intermediate molecular weight hyaluronic acid,
0.001%～0.3% digestion oligomerization hyaluronic acid, 0.01%～5% butanediol, 1%～15% glycerine, 0.001%～0.2% opopanax
Alcohol, 0.01%～1.5% allantoin, 0.1%～0.8% Carbopol, 0.01%～0.6% D-pantothenyl aleohol, 0.02%～1% hydroxide
Sodium, 0.05%～5% aloe extract, 0.05%～3% licorice root extract, 0.001%～0.5% methyl hydroxybenzoate, remaining is purifying
Water.
3. hyaluronic acid stoste according to claim 2, it is characterised in that including the component of following percentage：0.08% is high
Equimolecular quantity hyaluronic acid, 0.02% intermediate molecular weight hyaluronic acid, 0.1% digestion oligomerization hyaluronic acid, 3% butanediol, 8% is sweet
Oil, 0.05% bisabolol, 0.2% allantoin, 0.1% Carbopol, 0.2% D-pantothenyl aleohol, 0.07% NaOH, 0.5% aloe
Extract, 0.5% licorice root extract, 0.2% methyl hydroxybenzoate, remaining is purified water.
4. the hyaluronic acid stoste according to Claims 2 or 3, it is characterised in that the molecule of high molecular weight hyaluronic acid
Amount is more than 1800 kDa；The molecular weight of intermediate molecular weight hyaluronic acid be 400 kDa～800 kDa, digestion oligomerization hyaluronic acid
Molecular weight be less than 10 kDa.
5. the hyaluronic acid stoste according to Claims 2 or 3, it is characterised in that high molecular weight hyaluronic acid, middle decile
The mass ratio of son amount hyaluronic acid and digestion oligomerization hyaluronic acid is 4:1:5.
6. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that the matrix be non-woven fabrics or
Silk fabric is carrier.
7. the biological prosthetic patch of medical hyaluronic acid according to claim 1, it is characterised in that be applied to face acnes, skin
The postoperative reparation of scorching eczema, laser, photon delicate skin and nursing, promote wound healing, reach the barrier of reconstruction skin
The effect of sexual function.
8. the composition of the biological prosthetic patch of medical hyaluronic acid being based on described in claim 1, it is characterised in that preparation process is included
Following steps：
Step one：By high molecular weight hyaluronic acid, intermediate molecular weight hyaluronic acid, digestion oligomerization hyaluronic acid and Carbomer
980 are added in appropriate purified water, side edged stirring at low speed, fully it is swelling overnight, as the first component after being well mixed；
Step 2：By butanediol, glycerine, bisabolol, D-pantothenyl aleohol, aloe extract, licorice root extract, allantoin, oxybenzene
Methyl esters is added in appropriate purified water, as the second component after being uniformly dispersed；
Step 3：First component and the second component are mixed, is stirred in mixing, remaining purified water needed for being subsequently adding is stirred
NaOH is added after mixing 1 hour；
Step 4：The hyaluronic acid stoste being well mixed is poured in sterile aluminum foil bag, non-woven fabrics is put into or silk fabric matrix is filled
Divide absorption, pack after sealing, Co60 sterilizings, obtain the biological prosthetic patch of medical hyaluronic acid.
9. the preparation process of the biological prosthetic patch of medical hyaluronic acid according to claim 8, it is characterised in that in step 3 plus
The pH value for entering hyaluronic acid stoste after NaOH is 5～7.
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| CN107007876A (en) * | 2017-06-02 | 2017-08-04 | 江苏昌吉永生物科技股份有限公司 | Hyaluronic acid medical aseptic dressing and preparation method thereof |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN104983647A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Deep restoration mask and making method thereof |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
-
2016
- 2016-12-07 CN CN201611113430.XA patent/CN106606798A/en not_active Withdrawn
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1686158A (en) * | 2005-03-21 | 2005-10-26 | 凌沛学 | Adhesive bandage containing hyaluronic acid biological composition |
| CN104983647A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Deep restoration mask and making method thereof |
| CN105194719A (en) * | 2015-10-28 | 2015-12-30 | 成都清科生物科技有限公司 | Facial wound restoration dressing and plaster, and preparation methods thereof |
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