KR20180076871A - Silicone resin composition, method for preparing the same and scar medicine containing the same - Google Patents

Abstract

The present invention relates to a silicone resin composition, a method for preparing the same, and a scar treatment agent comprising the same. More specifically, the silicone resin composition comprises a) 5 to 70 wt % of a silicone resin, b) 0 to 40 wt % of wax, c) 1 to 15 wt % of an emulsifier, d) 0.01 to 10 wt % of a drug, e) 0.01 to 10 wt % of an activator, f) 0 to 30 wt % of a UV blocking agent, g) 0 to 5 wt % of an antioxidant, h) 0 to 80 wt % of water, and i) 0.1 to 5 wt % of a preservative. According to the present invention, the silicone resin composition uses a biocompatible raw material harmless to a human body, and is convenient by being safely and smoothly spread without stickiness. Also, the silicone resin composition is rapidly dried, and forms a thin silicone film to form a scar protection and a moisture environment. The silicone resin composition is specialized for preventing and alleviating erythema or pigmentation of a scar by UV blocking and antioxidant efficacy. The absorption of a drug and an activator, which are active ingredients, is improved by a high occlusive property and skin softening. Thus, it is possible to more soften and flatten a scar compared to the related art, and a synergic effect is secured with respect to prevention, treatment, and alleviation of a scar. In addition, the silicone resin composition has excellent flexibility, waterproofing properties, and moisturizing properties.

Description

TECHNICAL FIELD [0001] The present invention relates to a silicone resin composition, a method of producing the same, and a scar therapeutic agent containing the same. BACKGROUND ART [0002] SILICONE RESIN COMPOSITION, METHOD FOR PREPARING THE SAME AND SCAR MEDICINE CONTAINING THE SAME,

More particularly, the present invention relates to a silicone resin composition, a method for producing the silicone resin composition, and a scar therapeutic agent containing the silicone resin composition. More particularly, the present invention relates to a silicone resin composition, It forms a film to protect scars and create a moisture environment. It is effective in preventing and improving erythema and pigmentation of scars due to ultraviolet shielding and antioxidant effect. It has a high occlusive property and skin softening, , A silicone resin composition which is improved in absorption of an active ingredient and has a synergistic effect on scar prevention, treatment and improvement by making the scar more smooth and flat compared to the prior art, and which is excellent in flexibility, water resistance and moisturizing property, The present invention relates to a scar remedy comprising

The scar tissue initiates a largely accurate and rapid wound healing response when the skin or dermis is injured, such as by cutting or burning, and the damaged tissue is created as part of the reconstruction or repair process. However, if the reconstitution or restoration process is not well controlled, even a normal healing process will result in excessive scarring and pain.

The scars differ from the surrounding skin in color, roughness, or flexibility of the skin, resulting in severe mental stress when appearing on the appearance area, and scars on the area where the stretching is caused damage the skin tissue again Resulting in treatment time, and consequent contraction of the surrounding tissue causes a great inconvenience of life.

Conventionally, a method of preventing or improving scarring using a silicone gel sheet or silicone ointment has been disclosed. However, since it is tacky, it is inconvenient to use, the effect of scar treatment is not greater than expected, and the effect of preventing pigmentation or erythema is insufficient.

Korea Patent Publication No. 2013-0120537

In order to solve the problems of the prior art as described above, the present invention provides a safe, smooth, and non-sticky material that is harmless to the human body and forms a thin silicon film as it dries quickly to provide scar protection and moisture environment And is effective for prevention and improvement of erythema and pigmentation of scar due to ultraviolet shielding and antioxidant effect. High occlusive property and skin softening improve the absorption of drugs and activators, that is, active ingredients, It is another object of the present invention to provide a silicone resin composition, a method for producing the silicone resin composition, and a scar treatment agent containing the silicone resin composition, which are superior in flexibility, waterproofness and moisturizing property, as well as synergistic effects for prevention, treatment and improvement of scars by making the contrast scars more smooth and flat do.

These and other objects of the present invention can be achieved by the present invention described below.

D) from 0.01 to 10% by weight of the drug; e) from 5 to 70% by weight of a silicone resin; b) from 0 to 40% by weight of wax; From 0.01 to 10% by weight of an activator, from 0 to 30% by weight of an ultraviolet screening agent, g) from 0 to 5% by weight of an antioxidant, h) from 0 to 80% by weight of water and i) By weight based on the total weight of the composition.

The present invention also provides a method for producing a silicone composition, comprising the steps of: A) mixing 5 to 70 wt% of a silicone resin, 0 to 40 wt% of a wax, 1 to 15 wt% of an emulsifier, and 0 to 30 wt% of an ultraviolet screening agent at 60 to 80 캜; And B) 0.01 to 10 wt% of the drug, 0.01 to 10 wt% of the activator, 0 to 5 wt% of the antioxidant, 0 to 80 wt% of water and 0.1 to 5 wt% of the preservative are added to the mixed mixture, And mixing the resultant mixture at 70 DEG C with stirring to form a silicone resin composition.

The present invention also provides a scar therapeutic agent comprising the silicone resin composition.

According to the present invention, it is possible to use a biocompatible raw material which is harmless to the human body, which is safe, smooth and free from tackiness, and forms a thin silicon film with rapid drying to form scar protection and moisture environment. It is effective for prevention and improvement of erythema and pigmentation. It has high occlusive property and skin softening to improve the absorption of drugs and activator, that is, the active ingredient, so that scars are smoothened and flattened , A synergistic effect on treatment and improvement, and a silicone resin composition excellent in flexibility, water resistance and moisturizing property, a method for producing the same, and a scar treatment agent containing the same.

FIG. 1 is a diagram showing the steps of preparing a scar remedy for confirming the effect of a scar, showing a series of scarring treatments on each of the four areas of the rabbit ear, And FIG.
FIG. 2 shows histograms of the silicone resin composition prepared in Example 4 and the commercially available scar drug administered to the four scars of the subject prepared in FIG. 1 for histology analysis twice a day for 4 weeks , Then stained with Masson's trichrome stain and photographed with a microscope.

Hereinafter, the silicone resin composition of the present invention, a method for producing the same, and a scar treatment agent containing the same will be described in detail.

The present inventors have found that a silicone resin composition comprising a drug and an activator added to a silicone resin mixture comprising a silicone resin, a wax and an emulsifier having a predetermined composition ratio, and optionally containing an ultraviolet screening agent, an antioxidant, water and / When applied, they are rapidly dried and form a thin occlusive property to provide adequate light pressure while promoting scar protection and rehydration, resulting in capillary permeability and collagen deposition it has been found that synergistic effect compared with the conventional technique is exhibited in the ultraviolet screening and antioxidant efficacy, and it is confirmed that the scar is greatly improved due to the reduced collagen deposition, As a result, the present invention has been completed.

The silicone resin composition of the present invention comprises: a) from 5 to 70% by weight of a silicone resin, b) from 0 to 40% by weight of wax, c) from 1 to 15% by weight of an emulsifier, d) 0 to 30% by weight of an ultraviolet screening agent; g) 0 to 5% by weight of an antioxidant; h) 0 to 80% by weight of water; and i) 0.1 to 5% by weight of a preservative.

As another example, the silicone resin composition of the present invention may comprise a) from 5 to 70% by weight of a silicone resin, b) from 1 to 40% by weight of wax, c) from 1 to 15% by weight of an emulsifier, d) From 0 to 80% by weight of water and from 0.1 to 5% by weight of a preservative, based on the total weight of the composition, Features

As another example, the silicone resin composition of the present invention may comprise a) 15 to 70% by weight of a silicone resin, b) 1 to 40% by weight of wax, c) 1 to 15% by weight of an emulsifier, d) 0.1 to 10% From 0 to 30% by weight of an activator, f) from 0 to 30% by weight of an ultraviolet screening agent, g) from 0 to 5% by weight of an antioxidant, h) from 0 to 80% by weight of water and i) Features

The a) silicone resin may be at least three kinds selected from the group consisting of silicone elastomer, film forming agent, silicone fluid and cyclic siloxane. In this case, the silicone resin is safe as a harmless and harmless raw material, And it forms a thin silicon film as it dries quickly, thereby protecting scars and creating a moisture environment.

A) the silicone resin comprises, for example, from 2 to 75% by weight of a silicone elastomer, from 0.5 to 20% by weight of a film former, from 0.5 to 45% by weight of a silicone fluid and from 0 to 80% by weight of a cyclic siloxane, based on 100% It is safe as a biocompatible raw material harmless to human body within this range, is convenient because it does not tacky smoothly while being dried, and forms a thin silicon film as it is dried quickly, thereby creating scar protection and moisture environment.

In another example, the a) silicone resin comprises 5 to 50 wt% of a silicone elastomer, 2 to 10 wt% of a film forming agent, 2 to 40 wt% of a silicone fluid, and 0.1 to 65 wt% of a cyclic siloxane, based on 100 wt% %. It is safe as a biocompatible raw material harmless to the human body within this range, and it is convenient because it does not tacky smoothly while being dried, and it forms a thin silicon film while drying quickly, thereby creating scar protection and moisture environment.

In another example, the a) silicone resin comprises 10 to 50 wt% of a silicone elastomer, 2 to 10 wt% of a film forming agent, 2 to 40 wt% of a silicone fluid, and 5 to 65 wt% of a cyclic siloxane based on 100 wt% %. It is safe as a biocompatible raw material harmless to the human body within this range, and it is convenient because it does not tacky smoothly while being dried, and it forms a thin silicon film while drying quickly, thereby creating scar protection and moisture environment.

The silicone elastomer may be, for example, a crosslinked silicone polymer having a weight average molecular weight of 100,000 g / mol or more, or 100,000 to 10,000,000 g / mol.

As another example, the silicone elastomer may be selected from the group consisting of crosslinked dimethicone or dimethicones, stearylmethyl-dimethylsiloxane copolymer, polysilicon-11, cetearyldimethicon-vinyl dimethicone crosspolymer, dimethicon- A crosslinked polymer, and a dimethicone-vinyl dimethicone crosslinked polymer.

In the present description, the weight average molecular weight can be measured by gel permeation chromatography.

The silicone fluid may be, for example, a nonvolatile silicone fluid, and is preferably a nonvolatile silicone oil, and may be, for example, a glass capillary viscometer according to ASTM D445, IP71 using Ubbelod (manufactured by Fisher Scientific Company) The volatile silicone oil may have a viscosity at 25 ° C of from 2 to 105,000 cts, from 4 to 95,000 cts, from 1,000 to 14,000 cts, or from 11,000 to 14,000 cts, and has excellent durability and ease of application within this range.

As another example, the silicone fluid may be a silicone fluid (1) having a viscosity of 1 to 20 cst or 1 to 10 cst, a silicone fluid (2) having 10,000 to 15,000 cst or 11,000 to 14,000 cst, A silicone fluid (2) which may be at least one selected from the group consisting of silicone fluids (3) having a viscosity of from 100,000 cSt to 110,000 cSt, preferably from 10,000 to 15,000 cSt or from 11,000 to 14,000 cSt, (3), most preferably a silicone fluid (1) having a viscosity of 1 to 20 cst or 1 to 10 cst and a silicone fluid (3) of 80,000 to 120,000 cst or 90,000 to 110,000 cst In this case, the touch feeling is good, and durability and ease of application are excellent.

The weight ratio of the silicone fluid 1 to the silicone fluid 3 may be, for example, 1: 0.1 to 0.9, 1: 0.1 to 0.5 or 1: 0.15 to 0.4, There is an excellent effect of ease.

The weight ratio of the silicone fluid 2 to the silicone fluid 3 may be, for example, 1: 1 to 5 or 1: 1.5 to 2.5. Within this range, the silicone fluid 2 and the silicone fluid 3 have a good touch feeling and excellent durability and ease of application .

As another example, the silicone fluid may be a linear silicone polymer, and may be at least one selected from the group consisting of linear dimethicone polymers, linear polydimethylsiloxane polymers, polymethylethylsiloxane and polymethiphenylsiloxane, Durability and ease of application are excellent.

The film forming agent may be one of various film-forming silicone resins known in the art, for example, MQ type silicone resin, T type silicone resin or a mixture thereof. Specific examples thereof include trimethylsiloxysilicate, It may be at least one member selected from the group consisting of cyclopentasiloxane, propylsilsesquinic acid resin, and silsesquioxane. In this case, the silicone resin composition may have improved fluidity and tactile sensation, and may improve dispersion of other additives such as drugs It is effective.

The film forming agent has a viscosity at 25 DEG C of 200 to 2,000 cSt, 300 to 1,500 cSt, and a viscosity at 25 DEG C, which are measured using a glass capillary viscometer Ubbelode (manufactured by Fisher Scientific Ltd.) according to ASTM D445, Or 400 to 1,000 cst. Within this range, it is possible to improve the fluidity and feel of the silicone resin composition and to improve the dispersion of other additives such as drugs.

The cyclic siloxane is not particularly limited as long as it is a cyclic siloxane commonly used in this technical field. For example, it may be a hypermethylated cyclic siloxane. Specific examples thereof include cyclotetrasiloxane such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane and the like And cyclohexasiloxane such as cyclopentasiloxane and dodecamethylcyclohexasiloxane, and the like.

The silicone resin may be, for example, 15 to 65% by weight, 20 to 65% by weight, 15 to 40% by weight, 15 to 30% by weight, or 15 to 25% by weight, It is safe as a raw material, it is soft and easy to use because it is not tacky, and it forms a thin silicon film as it dries quickly, thereby protecting scars and creating a moist environment.

The b) wax may be at least one selected from the group consisting of beads wax, paraffin, sorbitan olivate, and silicone wax. In this case, the stability and spreadability of the formulation are improved.

The wax may be, for example, 1 to 30 wt%, 1 to 25 wt%, 1 to 15 wt%, 3 to 10 wt%, 4 to 8 wt%, or 5 to 7 wt% The stability and spreadability of the formulation can be improved.

The c) emulsifier may be at least one selected from the group consisting of fatty alcohols having a carbon number of 15 to 26 and a silicone emulsifier. In this case, it is possible to use a biocompatible raw material harmless to the human body, It is safe, has a smooth effect, has no stickiness, and has a convenient effect.

The emulsifying agent c) may be, for example, 1 to 10% by weight, 2 to 8% by weight, 2 to 7% by weight, or 2 to 5% by weight and, within this range, There is no stickiness and there is a convenient effect.

The fatty alcohols having 15 to 26 carbon atoms may be, for example, fatty alcohols having 15 to 23 carbon atoms or fatty alcohols having 16 to 20 carbon atoms, and preferably cetyl alcohol.

The silicone emulsifier is not particularly limited as long as it is a silicone emulsifier commonly used in the art. For example, the silicone emulsifier is selected from the group consisting of a PEG silicone emulsifier, a branched polyglycerol silicone emulsifier and a crosslinking polyglycerol silicone emulsifier And in this case, the effect of keeping the silicone resin composition in a uniform state is great.

The silicone emulsifier may have a viscosity of 1,000 to 5,000 cst, 1,500 to 2,500 cst, or 1,600 to 2,000 cst, for example, and the effect of maintaining the silicone resin composition in a uniform state within this range is significant.

The polyglycerin-based silicone emulsifier may be a crosslinked polyglycerin-modified dimethicone, and specific examples thereof include polyglyceryl-3-disiloxane dimethicone, polyglyceryl-3-polydimethyldisiloxylethyl dimethicone, lauryl polyglycerol Polyglycerin-3 crosspolymer, polyethylene glycol-9 polydimethylsiloxy ethyl dimethicone, dimethicone-polyglycerin-3 crosspolymer, And at least one selected from the group consisting of cetyl dimethicone copolyol, phage-10 dimethicone, and polyethylene glycol-7 dimethicone.

The emulsifier may have an HLB (hydrophile-lipophile balance) of 1 to 14, preferably 2 to 11, as measured by Griffin's method, and the effect of keeping the silicone resin composition in a homogenized state within this range is significant.

The d) drug may be at least one selected from the group consisting of an antioxidant, an anti-cancer agent, an anti-inflammatory agent, a hormone agent, and a calcium channel blocker. In this case, the antioxidant effect is effective for prevention and improvement of scarlet erythema and pigmentation. There is a synergistic effect in prevention, treatment and improvement of scarring due to rapid absorption.

The d) drug may be, for example, 0.1 to 5 wt%, 0.1 to 3 wt%, 0.1 to 2 wt%, 0.5 to 2 wt%, 1 to 2 wt%, or 1.5 to 2 wt% It is effective for the prevention and improvement of erythema and pigmentation of scars by antioxidant effect and it has a synergy effect for prevention, treatment and improvement of scar due to rapid absorption.

The antioxidant may be, for example, an ascorbic acid derivative, and in this case, the antioxidative effect and the scar treatment effect are excellent.

The ascorbic acid derivative is not particularly limited as long as it is a conventionally used or commercially available ascorbic acid derivative in the technical field. For example, the ascorbic acid derivative may be ascorbic acid acylated as a single or multiple fatty acid group and ascorbic acid fatty acid ester thereof, Specific examples thereof include ascorbyl laurate, ascorbyl myristate, ascorbyl palmitate, ascorbyl isopalmitate, ascorbyl-6-palmitate, ascorbyl stearate, ascorbyl behenate and their Metal salts, and preferably at least one selected from the group consisting of ascorbyl tetraisopalmitate.

The anticancer agent may be, for example, 5-fluorouracil, bleomycin, and the like.

The anti-inflammatory agent can be, for example, dipotassium glycyrrhizinate, allantoin or a mixture thereof, preferably allantoin, and when used with water, disodium can be used in combination with a chelating agent such as dithiecy, The anti-inflammatory effect and skin soothing effect are excellent.

The allantoin and disodium edetate may be, for example, in a weight ratio of 1: 0.01 to 1: 0.5, 1: 0.05 to 1: 0.2, or 1: 0.08 to 1: 0.12, .

The hormone agent may be, for example, triamcinolone, which is effective for the improvement and treatment of scarring.

The calcium channel blocker may be verapamil, for example, and the scar treatment effect is excellent in this case.

The e) activator may be one or more selected from the group consisting of a vitamin derivative and an onion extract (Allium Cepa). In this case, the absorption into the scar with the drug is improved, thereby preventing, Synergy effect occurs.

E) the activator is, for example, 1 to 5% by weight, 1 to 5% by weight. 2 to 5% by weight, or 2 to 3% by weight. Within this range, absorption into the scar with the drug is improved, resulting in synergistic effects in preventing, treating and improving scarring in comparison with the prior art.

In the present description, vitamin derivatives and onion extracts can be used in the technical field or are not particularly limited when they are commercially available vitamin derivatives.

The vitamin derivative may be at least one kind selected from the group consisting of derivatives of vitamins A, C, D and E. In this case, the absorption of the vitamin into the scar with the drug is improved to prevent, Synergy occurs.

The onion extract may be, for example, an extract of a dried onion containing water, alcohol or water-alcohol, and a dried onion known as a dried onion chip obtained from a stock plant onion, for example, Extracting the components with an extracting solvent and then evaporating the extract solution (leaching solution) at an elevated temperature of 30 ° C or higher under reduced pressure to obtain an onion extract, followed by dissolving in water, alcohol or water-alcohol to obtain onion extract Can be obtained.

The liquid onion extract may be, for example, 5 to 60 wt%, 10 to 50 wt%, 10 to 40 wt%, or 10 to 15 wt% of the solvent.

The alcohol may be at least one selected from the group consisting of ethanol, isopropanol, propanol, butylene glycol and propylene glycol.

In the present description, the weight of the onion extract is based on the solids content.

As a specific example, the onion extract may be prepared as follows:

Dried onions can be extracted with purified water, for example, as a ratio of 1:16 drug (dried onion) to extraction solvent (water). The ratio of dry chemical to natural extract corresponds to 1.8: 1 or 1.5-2.2: 1. The ratio of dry chemical to liquid extract is 0.16: 1. Drugs (eg, 16 kg onion chips) are exclusively leached with hot water (80-90 ° C). Then, the leachate is evaporated at 55 ° C or higher under reduced pressure to obtain an onion extract (concentrated extract). Here, heating is carried out briefly (141 ° C for 3 seconds). The resulting onion extract is a concentrated liquid, which is dissolved in a water, alcohol or water-alcohol mixture to give liquid extracts of the abovementioned proportions. Here a reddish brown to brown liquid with characteristic aroma is produced. This extract is miscible with water in any ratio and has a relative density of 1.00 to 1.03 g / ml at 20 占 폚. When water / alcohol (especially ethanol) is used in processing, approximately 13 to 20% (v / v) of alcohol (e.g., ethanol) may be present. The dry residue (after 2 hours at 105 캜) is at least 7.0% (m / m). With respect to microbiological purity, the product meets the requirements of Category 3 of German Pharmacopeia 10.

The f) ultraviolet screening agent may be, for example, an inorganic ultraviolet screening agent, an organic ultraviolet screening agent, or a mixture thereof. In this case, the ultraviolet screening agent is effective in preventing and improving erythema and pigmentation of a scar.

The f) ultraviolet screening agent may be, for example, 0.1 to 30 wt%, 0 to 20 wt%, 0.1 to 20 wt%, 0 to 15 wt%, or 0.1 to 15 wt% It is effective in preventing and improving pigmentation.

The inorganic ultraviolet screening agent is not particularly limited when it is an inorganic ultraviolet screening agent ordinarily used in the art, but it may preferably be zinc oxide, titanium oxide or a mixture thereof, preferably zinc oxide. In this case, It is effective in preventing and improving erythema and pigmentation.

The organic ultraviolet screening agent may be at least one selected from the group consisting of octinosate, octylsaltate, octocrylene and avobenzone, although it is not particularly limited in the case of an organic ultraviolet screening agent ordinarily used in the art , Preferably octinosate. In this case, it is effective in preventing and improving erythema and pigmentation of the scar.

As another example, the ultraviolet screening agent may be at least one selected from the group consisting of benzophenones such as dihydroxybenzophenone, melanin, ethyl paraaminobenzoate, 2-ethylhexyl paradimethylbenzoate, synonym, 2-ethylhexyl phamethoxycinnamate, 2 (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, anthranilate, cinnamate, salicylate, derivatives of dibenzoylmethane, derivatives of camphor, derivatives of triazine, derivatives of benzotriazole, derivatives of benzylmalonate, derivatives of benzimidazole, derivatives of imidazoline, benzoalyl, derivatives of p-aminobenzoic acid, titanium oxide and oxides Zinc, and the like.

The h) water may be, for example, from 0.1 to 80% by weight, from 30 to 80% by weight, from 45 to 70% by weight, or from 50 to 65% by weight and sufficiently dissolving the drug, activator, antioxidant, , Is gentle and has no stickiness, is convenient and helps to form a thin silicon film as it dries quickly.

The h) water may be, for example, purified water or distilled water.

The g) antioxidant may be, for example, 0.1 to 5% by weight, 0.5 to 3% by weight or 0.5 to 2% by weight, and within this range, it is effective in preventing and improving erythema and pigmentation of scar.

In the present invention, the antioxidant is not particularly limited as long as it is an antioxidant commonly used in the art. For example, it may be at least one selected from the group consisting of butylhydroxyanisole, gallic acid, propyl gallate, and erythorbic acid.

The f) preservative may be, for example, imidazolidinyl urea, methylparaben, salicylic acid, methylchloroisothiazolinone, methylisothiazolinone, ethylparaben, But are not limited to, ethylparaben, butylparaben, propylparaben, isopropylparaben, phenoxyethanol, DMDM Hydantoin, 1,2-hexanediol (1,2, -Hexanediol, capryloylglycine, glyceryl caprylate, sodium levulinate, zinc gluconate, copper gluconate, zinc pyrrolidone carboxylate acid, copper pyrrolidone carboxylate acid, phytosphingosine , Phytosphingosine derivatives, benzoyl peroxide, pyrrothonol amine, zinc pyrocite, selenium sulfide, econazole, ketoconazole, erythromycin and clindamycin It is at least one, and preferably 1,2-hexanediol, and in this case is excellent in preserving effects of the silicone resin composition.

The process for producing the silicone resin composition of the present invention comprises the steps of: A) mixing 5 to 70% by weight of a silicone resin, 1 to 40% by weight of wax, 1 to 15% by weight of an emulsifier and 0 to 30% by weight of an ultraviolet screening agent, ; And B) 0.01 to 10 wt% of the drug, 0.01 to 10 wt% of the activator, 0 to 5 wt% of the antioxidant, 0 to 80 wt% of water and 0.1 to 5 wt% of the preservative are added to the mixed mixture, And agitating and mixing at 70 ° C.

The components used in steps A) and B) above include all of the above-mentioned contents.

The mixing in step A) may be carried out at 60 to 75 占 폚, 65 to 70 占 폚, or 63 to 67 占 폚, for example.

In step B), for example, a mixed solution prepared by mixing the drug or a part thereof with water at 50 to 75 ° C is first added to and mixed with the mixture prepared in step A), and then mixed with the activator, In this case, the silicone resin composition is uniformly dispersed, and the produced silicone resin composition softens on the skin and is not tacky, so that it is easy to use and the absorption of the active ingredient is improved.

The mixed solution of step B) may be prepared by mixing the drug or a part thereof with water at 60 to 70 ° C or 63 to 67 ° C, for example.

When the mixture solution is added to the mixture prepared in the step A), it can be maintained at 50 to 75 ° C, for example, and the dispersion is homogeneous within the range, so that the silicone resin composition is soft and does not stick to the skin It is easy to use and has an effect of improving the absorption of the active ingredient.

When the mixed solution is added to the mixture in the step B), it may be maintained at 60 to 70 ° C or 63 to 67 ° C, for example.

The activator, the antioxidant and the preservative may be added to the mixture prepared in the step A), for example, when the mixture is cooled to 45 to 55 ° C, the dispersion is uniform within the range, The produced silicone resin composition softens on the skin and is not tacky, so that it is easy to use and the absorption of the active ingredient is improved.

As another example, the activator, the antioxidant, and the preservative may be added to the mixture prepared in the step A), and then the mixture is cooled to 48 to 52 ° C.

The scar remedy of the present invention is characterized by comprising the silicone resin composition.

In the present description, the scar therapeutic agent is not limited to the name, but may be any of those which prevent, ameliorate or treat scarring, and examples thereof include scar remedy, scar inhibitor, scar drug and the like.

The scar remedy may be, for example, a sheet type, a cream type or a gel type, preferably a cream type or a gel type. In this case, the scar remedy is convenient because it does not stick to the skin smoothly and can be arbitrarily adjusted It has a simple and economical effect.

The scar therapeutic agent may have an ultraviolet barrier property (SPE) according to ISO 24444 of, for example, 25 or more, 30 or more, or 30 to 50, and within this range, the other properties of the silicone resin composition may be adversely affected It is effective in preventing and improving erythema and pigmentation caused by UV rays.

The scar remedy may be, for example, 40% or more, 45% or more, 50% or more, or 50% or more of the antioxidative effect by the DPPH method. If the scar therapeutic agent does not adversely affect other physical properties of the silicone resin composition It is also effective for prevention and improvement of erythema and pigmentation caused by antioxidant effect.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the present invention. Such variations and modifications are intended to be within the scope of the appended claims.

[Example]

The components contained in the silicone resin mixture in the following examples and comparative examples are as follows from Dow Corning.

1) Silicone elastomer

1-1) ST-Elastomer 10

1-2) TI-3021

2) silicone resin ( Film forming agent )

2-1) TI-7021 (400-1,000 cSt)

3) Silicone fluid

3-1) TI-2021 (2 ~ 4 cst) used to improve touch feeling)

3-2) TI-1050 (Viscosity range is varied, 95,000 ~ 105,000 cst product is used for viscosity control)

3-3) Q7-912 0 (11,875-13,125 cst)

4) Annular Siloxane

4-1) ST-Cyclomethicone 5-NF

Example  1 (stick type)

64.5 g of the silicone resin mixture (Q7-9120: TI-3021: TI-1050: Elastomer 10: TI-7021: 5-NF = 1: 6: 2: 8: 3: 80 weight ratio) . 25 g of beeswax and 7 g of cetyl alcohol as an emulsifier were added with stirring at 70. When completely mixed, the temperature was lowered to 55, 2 g of onion extract, 0.5 g of ascorbyl tetraisopalmitate and 1 g of 1,2-hexanediol 1 g. Put it in a container before completely cooking.

Example  2 (cream or gel type)

A silicone emulsifier (Dow corning ES-5300, viscosity 1800 mm < ² >) was added to 20 g of a silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: / s) and 7 g of sorbitan olivate, and the mixture is heated to 65 and stirred. In another reactor, add 0.5 g of allantoin, 0.05 g of disodium dithiophosphate, and 64.45 g of purified water. The mixture is heated to 65 and stirred. 65, the contents of the reactor containing the purified water are slowly poured into the reactor containing the silicone resin and stirred. When the phases are completely mixed, stop heating and add 2 g of onion extract, 1 g of tocopheryl acetate and 1 g of 1,2-hexanediol as a preservative. Continue stirring until completely cooled.

Example  3 (cream or gel type)

20 g of a silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: 10: 30 by weight), 10 g of zinc oxide, 5 g of octinosate, (Dow corning ES-5300, viscosity 1800 mm ² / s) 4 g and sorbitan olivate 5 g, and heat to 65 and stir. In another reactor, 0.5 g of allantoin, 0.05 g of disodium dithiophosphate and 51.45 g of purified water are added and the mixture is heated to 65 and stirred. 65, the contents of the reactor containing the purified water are slowly poured into the reactor containing the silicone resin and stirred. When the phases are completely mixed, stop heating and add 2 g of onion powder, 1 g of tocopheryl acetate and 1 g of 1,2-hexanediol as preservative. Continue stirring until completely cooled.

Example  4 (cream or gel type)

A silicone emulsifier (Dow corning ES-5300, viscosity 1800 mm < ² >) was added to 20 g of a silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10 = 10: 30: 20: / s) and 7 g of sorbitan olivate, and the mixture is heated to 65 and stirred. In another reactor, 0.1 g of verapamil, 0.5 g of allantoin, 0.05 g of disodium dithiophosphate and 64.35 g of purified water are added and the mixture is heated to 65 and stirred. 65, the contents of the reactor containing the purified water are slowly poured into the reactor containing the silicone resin and stirred. When the phases are completely mixed, stop heating and add 2 g of onion powder, 1 g of tocopheryl acetate and 1 g of 1,2-hexanediol as preservative. Continue stirring until completely cooled.

Example  5 (cream or gel type)

20 g of a silicone resin mixture (TI-1050: TI-2021: TI-3021: TI-7021: Elastomer 10: 5-NF = 5: 30: 5300, viscosity 1800 mm ² / s) and 7 g of sorbitan olivate, and the mixture is heated to 65 and stirred. In another reactor, 0.1 g of verapamil, 0.5 g of allantoin, 0.05 g of disodium dithiophosphate and 64.35 g of purified water are added and the mixture is heated to 65 and stirred. 65, the contents of the reactor containing the purified water are slowly poured into the reactor containing the silicone resin and stirred. When the phases are completely mixed, stop heating and add 2 g of onion powder, 1 g of tocopheryl acetate and 1 g of 1,2-hexanediol as preservative. Continue stirring until completely cooled.

Example  6 (wax-free type)

(Dow corning Emulsifier 10, HLB ratio of 2.2%) was added to 40 g of a silicone resin mixture (Q7-9120: TI-1050: TI-3021: TI-7021: Elastomer 10 = 1: 6: Viscosity 1100 ~ 3500 cps or cst) and stir at room temperature. In another reactor, 0.5 g of allantoin, 0.05 g of disodium dithiophosphate and 55.45 g of purified water are added, and the mixture is heated to 60 and stirred. After the reactor containing the purified water is completely cooled, the contents are slowly poured into a reactor containing the silicone resin and stirred. When the phases are completely mixed, high-speed stirring is performed using a homogenizer.

Comparative Example  1 to 4 (commercially available scar remedy)

Kelo-cote Solaire (manufactured by Formulated Solutions LLC), Dermatix Ultra gel (manufactured by Toshiki International Singapore Pte Ltd.), and Bentlax gel (Taihei Pharmaceutical Co., Ltd.) were used as Comparative Examples 1 to 4 Respectively.

[Test Example]

Properties of the silicone resin composition prepared in Examples 4 to 5 and the scar treatments of Comparative Examples 1 to 4 were measured by the following methods, and the results are shown in Table 1 and FIG. 2 below.

* Antioxidant effect: Measured by DPPH method. The higher the value, the better the antioxidant effect.

* UV protection performance (SPF): Measured by human skin patch test according to ISO 2444.

The degree of stickiness was measured on the basis of the touch feeling when the sample was applied to the skin, and +++, ++ in the case of no stickiness, + in the case of very sticky.

division Example 4 Example 5 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Antioxidant performance 52 53 One 10 2 38 UV protection performance 32 30 0 30 0 0 Stickiness +++ +++ + + +++ ++

As shown in Table 1, the silicone resin compositions of the present invention (Examples 4 and 5) are excellent in antioxidation performance and ultraviolet shielding performance compared to Comparative Examples 1 to 4, .

Further, as shown in FIG. 2, the silicone resin composition of the present invention (Example 4) greatly reduces abnormal collagen compared to Comparative Examples 3 and 4, and increases normal pattern collagen .

Claims (21)

a) from 5 to 70% by weight of a silicone resin, b) from 0 to 40% by weight of waxes, c) from 1 to 15% by weight of an emulsifier, d) from 0.01 to 10% by weight of a drug, e) 0 to 30% by weight of a blocking agent, g) 0 to 5% by weight of an antioxidant, h) 0 to 80% by weight of water and i) 0.1 to 5% by weight of a preservative.
Silicone resin composition. The method according to claim 1,
Wherein the a) silicone resin is at least three kinds selected from the group consisting of a silicone elastomer, a film forming agent, a silicone fluid and a cyclic siloxane
Silicone resin composition. 3. The method of claim 2,
Wherein the silicone resin is a mixture of 2 to 75% by weight of a silicone elastomer, 0.5 to 20% by weight of a film former, 0.5 to 45% by weight of a silicone fluid and 0 to 80% by weight of a cyclic siloxane based on 100% Featured
Silicone resin composition. The method according to claim 1,
The b) wax is at least one selected from the group consisting of beads wax, paraffin, sorbitan olivate, and silicone wax
Silicone resin composition. The method according to claim 1,
And b) the wax is contained in an amount of 1 to 40% by weight
Silicone resin composition. The method according to claim 1,
Wherein the c) emulsifier is at least one selected from the group consisting of fatty alcohols having 15 to 26 carbon atoms and silicone emulsifiers
Silicone resin composition. The method according to claim 1,
The d) drug is at least one selected from the group consisting of an antioxidant, an anti-inflammatory agent and a calcium channel blocker
Silicone resin composition. The method according to claim 1,
Wherein the e) activator is at least one selected from the group consisting of a vitamin derivative and an onion extract (Allium Cepa)
Silicone resin composition. The method according to claim 1,
The f) ultraviolet screening agent is an inorganic ultraviolet screening agent, an organic ultraviolet screening agent, or a mixture thereof
Silicone resin composition. The method according to claim 1,
And the f) ultraviolet screening agent is contained in an amount of 0.1 to 30% by weight
Silicone resin composition. The method according to claim 1,
And g) the antioxidant is contained in an amount of 0.1 to 5% by weight
Silicone resin composition. The method according to claim 1,
And h) water is contained in an amount of 0.1 to 80% by weight
Silicone resin composition. The method according to claim 1,
The f) preservative may be selected from the group consisting of Imidazolidinyl Urea, Methylparaben, Salicylic acid, Methylchloroisothiazolinone, Methylisothiazolinone, Ethylparaben Butylparaben, propylparaben, isopropylparaben, phenoxyethanol, DMDM Hydantoin, 1,2-hexanediol, and the like. ), Capryloylglycine, glyceryl caprylate, sodium levorinate, zinc gluconate, copper gluconate, zinc pyrrolidone carboxylate acid, copper pyrrolidone carboxylate acid, phytosphingosine, One selected from the group consisting of a tosin phosphodiester, benzoyl peroxide, pyrrothonol amine, zinc pyrocite, selenium sulfide, econazole, ketoconazole, erythromycin and clindamycin Characterized in that the dealer
Silicone resin composition. A) mixing 5 to 70% by weight of a silicone resin, 1 to 40% by weight of wax, 1 to 15% by weight of an emulsifier and 0 to 30% by weight of an ultraviolet screening agent at 60 to 80 캜 with stirring; And
B) 0.01 to 10% by weight of the drug, 0.01 to 10% by weight of the activator, 0 to 5% by weight of the antioxidant, 0 to 80% by weight of water and 0.1 to 5% by weight of the preservative are added to the mixed mixture, Lt; RTI ID = 0.0 > C, < / RTI >
A method for producing a silicone resin composition. 15. The method of claim 14,
In the step B), a mixture solution prepared by mixing the drug or a part thereof with water at 50 to 75 ° C is first added to the mixture prepared in the step A), mixed, and then the activator, the antioxidant and the preservative Characterized in that
A method for producing a silicone resin composition. 16. The method of claim 15,
Characterized in that the mixed solution is maintained at 50 to 75 ° C when it is added to the mixture prepared in the step A)
A method for producing a silicone resin composition. 16. The method of claim 15,
Wherein the activator, the antioxidant and the preservative are added to the mixture prepared in the step A), and then the mixture is cooled to 45 to 55 ° C.
A method for producing a silicone resin composition. A silicone resin composition comprising the silicone resin composition according to any one of claims 1 to 13
Scar remedy. 19. The method of claim 18,
Wherein the scar therapeutic agent is a sheet type, a cream type or a gel type
Scar remedy. 19. The method of claim 18,
The scar therapeutic agent is characterized by having an ultraviolet barrier index (SPE) according to ISO 24444 of 25 or more
Scar remedy. 18. The method of claim 17,
Wherein the scar therapeutic agent has an antioxidative effect by DPPH method of 40% or more
Scar remedy.

Images