CN113456877B - Organosilicon foam medical dressing and preparation method and application thereof - Google Patents
Organosilicon foam medical dressing and preparation method and application thereof Download PDFInfo
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- CN113456877B CN113456877B CN202110778387.3A CN202110778387A CN113456877B CN 113456877 B CN113456877 B CN 113456877B CN 202110778387 A CN202110778387 A CN 202110778387A CN 113456877 B CN113456877 B CN 113456877B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
Abstract
The invention discloses an organosilicon foam medical dressing and a preparation method and application thereof, belongs to the technical field of medical dressings, and particularly discloses the following raw materials in parts by weight: 90-110 parts of vinyl silicone oil, 20-60 parts of hydroxyl silicone oil, 0.1-4 parts of hydrogen-containing silicone oil, 10-40 parts of chitosan, 5-20 parts of sodium alginate, 10-50 parts of filler, 1-10 parts of white carbon black, 0.01-10 parts of inhibitor and 0.02-20 parts of catalyst. Meanwhile, the preparation method mainly comprises the following steps: mixing part of the raw materials uniformly to obtain group A glue; then uniformly mixing the rest raw materials to obtain a group B glue; and finally, mixing and stirring the group A glue and the group B glue uniformly, and vulcanizing to obtain the organic silicon foam medical dressing. The invention has good promotion effect on wound healing, can solve the problem that most of viscous materials in the prior art are polyurethane and acrylic resin which cause irritation and anaphylactic reaction to human bodies, and has great market application and popularization values.
Description
Technical Field
The invention relates to the technical field of medical dressings, in particular to an organic silicon foam medical dressing and a preparation method and application thereof.
Background
Medical dressings are items used to cover sores, wounds, or other lesions in medical material. With the intensive research on the pathophysiology of the wound healing process, people understand the wound healing process more and more deeply, thereby leading to the continuous improvement and development of medical wound dressings. At present, compared with the early days, the novel dressing for wound surface care is revolutionarily changed, and a plurality of medical dressings with different performances can be selected by clinical care personnel.
The medical dressing in the prior art comprises natural gauze, synthetic fiber dressing, polymeric film dressing, foaming polymeric dressing, hydrocolloid dressing, alginate dressing and the like. The natural gauze has strong performance of rapidly absorbing wound surface exudate, is simple in production and processing process, but has high permeability, is easy to dehydrate the wound surface and adhere to the wound surface, can cause mechanical injury again during replacement, and is easy to pass through external environment microorganisms, so that the probability of cross infection of the wound is high, and the frequent replacement process of the natural gauze in the using process is complicated, and the pain of a patient is easily increased. In addition, the poly-membrane dressing has the characteristic that gases such as oxygen, water vapor and the like can freely penetrate, cross infection can be prevented, and secondary mechanical damage can be avoided during replacement. In addition, most of the adhesive materials of the medical dressing in the prior art are polyurethane and acrylic resin, but the materials are easy to cause skin allergy.
Therefore, how to provide a medical dressing with antibacterial, hemostatic and exudate absorbing functions is a problem that needs to be solved by those skilled in the art.
Disclosure of Invention
In view of the above, the invention provides an organosilicon foam medical dressing which has the effects of stopping bleeding and absorbing seepage, can prevent cross infection of wounds and has low sensitization rate.
In order to achieve the purpose, the invention adopts the following technical scheme:
the organic silicon foam medical dressing comprises the following raw materials in parts by weight: 90-110 parts of vinyl silicone oil, 20-60 parts of hydroxyl silicone oil, 0.1-4 parts of hydrogen-containing silicone oil, 10-40 parts of chitosan, 5-20 parts of sodium alginate, 10-50 parts of filler, 1-10 parts of white carbon black, 0.01-10 parts of inhibitor and 0.02-20 parts of catalyst.
Preferably, the vinyl silicone oil is vinyl-terminated polydimethylsiloxane or side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 0.01-2.89% and a viscosity of 200-150000mPa & s;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 0.5-8.0%, and the viscosity is 25-100000mPa & s;
the hydrogen-containing silicone oil is terminal group type hydrogen-containing silicone oil or side chain type hydrogen-containing silicone oil; the hydrogen content of the hydrogen-containing silicone oil is 0.1-1.6%, and the viscosity is 5-3000mPa & s;
the pH value of the sodium alginate is 6.8-7.2, and the viscosity is less than or equal to 2000 mPa.
Has the advantages that: the organic silicon functional dressing provided by the invention contains chitosan, has the effects of stopping bleeding, adsorbing wound exudate and improving scar formation, and has the effects of obviously promoting the growth of granulation tissues of wounds, improving healing speed, inhibiting and killing various bacteria, promoting endothelial growth, reducing fibrous tissue hyperplasia and spot scar formation, and the effects of stopping bleeding of sodium alginate, and has the effects of resisting bacteria, stopping bleeding, adsorbing exudate and improving scars.
Preferably, the filler is methyl silicone resin or vinyl silicone resin.
Preferably, the particle size of the white carbon black is 10-100nm, and the purity is more than or equal to 99%.
Preferably, the catalyst is chloroplatinic acid-isopropyl alcohol complex, chloroplatinic acid-divinyltetramethyldisiloxane, chloroplatinic acid-tetramethyltetravinylcyclotetrasiloxane or chloroplatinic acid-polyvinyl silicone oil.
Preferably, the inhibitor is a natural aromatic compound, and the structural general formula of the natural aromatic compound is C n H 2n-x Or C n H 2n-x O y Wherein x =2,4,6,8,10.
Preferably, the natural aromatic compound is one or a combination of any several of phenylacetylene, 1-ethynyl-1-cyclohexanol, tetramethyl tetravinylcyclotetrasiloxane, 2-methyl-3-butynyl-2-ol, 3-methyl-1-ethynyl-3-ol, 3, 5-dimethyl-1-hexynyl-3-ol and 3-methyl-1-dodecyn-3-ol.
The preparation method of the organosilicon foam medical dressing is characterized by comprising the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain a group B gel;
(3) And mixing and stirring the group A glue and the group B glue uniformly, and vulcanizing to obtain the organic silicon foam medical dressing.
Preferably, in the step (3), the vulcanization temperature is 80-120 ℃, and the vulcanization time is 3-30min.
An application of a silicone foam medical dressing in a medical dressing.
According to the technical scheme, compared with the prior art, the invention discloses and provides the organosilicon foam medical dressing and the preparation method and the application thereof, the invention can effectively solve the problems that mechanical wound wounds are difficult to heal and scars are formed and the like caused by that the conventional medical dressings are mostly gauze, non-woven fabrics, absorbent cotton, hydrocolloid or sodium alginate directly contact the wounds, has a good promoting effect on wound healing, can solve the problems that in the prior art, most of viscous materials are polyurethane and acrylic resin and generate irritation and anaphylactic reaction on human bodies, and has great market application and popularization values.
Detailed Description
The following will clearly and completely describe the technical solutions in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The organic silicon pressure-sensitive adhesive comprises the following raw materials in parts by weight: 90 parts of vinyl silicone oil, 20 parts of hydroxyl silicone oil, 0.1 part of hydrogen-containing silicone oil, 10 parts of chitosan, 5 parts of sodium alginate, 10 parts of filler, 1 part of white carbon black, 0.01 part of inhibitor and 0.02 part of catalyst.
Wherein the hydrogen-containing silicone oil is end group type hydrogen-containing silicone oil or side chain type hydrogen-containing silicone oil, the hydrogen content of the hydrogen-containing silicone oil is 0.1 percent, and the viscosity is 5mPa & s;
the vinyl silicone oil is vinyl-terminated polydimethylsiloxane or side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 0.01% and a viscosity of 150000 mPas;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 0.5 percent, and the viscosity is 100000mPa & s;
the pH value of the sodium alginate is 6.8, and the viscosity is less than or equal to 2000 mPas.
The filler is methyl silicone resin.
The white carbon black has a particle size of 10-100nm and a purity of more than or equal to 99%.
The catalyst is one of chloroplatinic acid-isopropanol complex.
The inhibitor is a natural aromatic compound, and specifically is a mixture of phenylacetylene, 1-ethynyl-1-cyclohexanol and tetramethyltetravinylcyclotetrasiloxane in any proportion.
A preparation method of an organosilicon foam medical dressing specifically comprises the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain B group glue;
(3) Mixing the group A glue and the group B glue, stirring uniformly, and vulcanizing at 120 ℃ for 3min to obtain the organic silicon foam medical dressing.
Example 2
An organosilicon foam medical dressing, organosilicon pressure-sensitive adhesive include the following raw materials of part by weight: 110 parts of vinyl silicone oil, 60 parts of hydroxyl silicone oil, 4 parts of hydrogen-containing silicone oil, 40 parts of chitosan, 20 parts of sodium alginate, 50 parts of filler, 10 parts of white carbon black, 10 parts of inhibitor and 20 parts of catalyst.
Wherein the hydrogen-containing silicone oil is terminal group type hydrogen-containing silicone oil or side chain type hydrogen-containing silicone oil, the hydrogen content of the hydrogen-containing silicone oil is 1.6%, and the viscosity of the hydrogen-containing silicone oil is 3000mPa & s;
the vinyl silicone oil is vinyl-terminated polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 2.89% and a viscosity of 200 mPas;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 8.0 percent, and the viscosity is 25mPa & s;
the pH value of the sodium alginate is 7.2, and the viscosity is less than or equal to 2000 mPas.
The filler is one of vinyl silicone resin.
The white carbon black has a particle size of 10-100nm and a purity of more than or equal to 99%.
The catalyst is chloroplatinic acid-divinyl tetramethyl disiloxane.
The inhibitor is natural aromatic compound, specifically 3-methyl-1-ethynyl-3-ol, 3, 5-dimethyl-1-hexynyl-3-ol and 3-methyl-1-dodecyn-3-ol in any ratio.
A preparation method of an organosilicon foam medical dressing specifically comprises the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain a group B gel;
(3) Mixing the group A glue and the group B glue, stirring uniformly, and vulcanizing at 80 ℃ for 30min to obtain the organic silicon foam medical dressing.
Example 3
An organosilicon foam medical dressing, organosilicon pressure-sensitive adhesive include the following raw materials of part by weight: 100 parts of vinyl silicone oil, 40 parts of hydroxyl silicone oil, 2 parts of hydrogen-containing silicone oil, 25 parts of chitosan, 13 parts of sodium alginate, 30 parts of filler, 5.5 parts of white carbon black, 5 parts of inhibitor and 10 parts of catalyst.
Wherein the hydrogen-containing silicone oil is end group type hydrogen-containing silicone oil or side chain type hydrogen-containing silicone oil, the hydrogen content of the hydrogen-containing silicone oil is 7.6 percent, and the viscosity is 1500mPa & s;
the vinyl silicone oil is side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 1.4% and a viscosity of 80000 mPas;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 4.2 percent, and the viscosity is 50000mPa & s;
the pH value of the sodium alginate is 7, and the viscosity is less than or equal to 2000 mPas.
The filler is one of methyl silicone resins.
The white carbon black has a particle size of 10-100nm and a purity of more than or equal to 99%.
The catalyst is chloroplatinic acid-tetramethyl tetravinylcyclotetrasiloxane.
The inhibitor is natural aromatic compound, specifically 2-methyl-3-butynyl-2-ol, 3-methyl-1-ethynyl-3-ol and 3, 5-dimethyl-1-hexynyl-3-ol in any proportion.
A preparation method of an organosilicon foam medical dressing specifically comprises the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain B group glue;
(3) Mixing the group A glue and the group B glue, stirring uniformly, and vulcanizing at 100 ℃ for 16min to obtain the organic silicon foam medical dressing.
Example 4
An organosilicon foam medical dressing, organosilicon pressure-sensitive adhesive include the following raw materials of part by weight: 95 parts of vinyl silicone oil, 30 parts of hydroxyl silicone oil, 1 part of hydrogen-containing silicone oil, 12 parts of chitosan, 8 parts of sodium alginate, 20 parts of filler, 3 parts of white carbon black, 2 parts of inhibitor and 5 parts of catalyst.
Wherein the hydrogen-containing silicone oil is side chain type hydrogen-containing silicone oil, the hydrogen content of the hydrogen-containing silicone oil is 3.8 percent, and the viscosity is 800mPa & s;
the vinyl silicone oil is side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 0.7% and a viscosity of 120000 mPas;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 2.1 percent, and the viscosity is 750000mPa & s;
the pH value of the sodium alginate is 6.9, and the viscosity is less than or equal to 2000 mPas.
The filler is one of vinyl silicone resin.
The white carbon black has a particle size of 10-100nm and a purity of more than or equal to 99%.
The catalyst is one of chloroplatinic acid-polyvinyl silicone oil.
The inhibitor is natural aromatic compound, and specifically is one or combination of any more of phenylacetylene, 1-ethynyl-1-cyclohexanol, tetramethyltetravinylcyclotetrasiloxane, 2-methyl-3-butynyl-2-ol, 3-methyl-1-ethynyl-3-ol, 3, 5-dimethyl-1-hexynyl-3-ol and 3-methyl-1-dodecyn-3-ol.
A preparation method of an organosilicon foam medical dressing specifically comprises the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain B group glue;
(3) Mixing the group A glue and the group B glue, stirring uniformly, and vulcanizing at 90 ℃ for 10min to obtain the organic silicon foam medical dressing.
Example 5
An organosilicon foam medical dressing, organosilicon pressure-sensitive adhesive include the following raw materials of part by weight: 105 parts of vinyl silicone oil, 50 parts of hydroxyl silicone oil, 3 parts of hydrogen-containing silicone oil, 30 parts of chitosan, 17 parts of sodium alginate, 40 parts of filler, 7.5 parts of white carbon black, 7.5 parts of inhibitor and 15 parts of catalyst.
Wherein the hydrogen-containing silicone oil is end group type hydrogen-containing silicone oil, the hydrogen content of the hydrogen-containing silicone oil is 1.2%, and the viscosity is 2300mPa & s;
the vinyl silicone oil is side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 2.0% and a viscosity of 100000mPa & s;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 6.2 percent, and the viscosity is 750000 mPa.s;
the pH value of the sodium alginate is 7.1, and the viscosity is less than or equal to 2000 mPas.
The filler is one of methyl silicone resins.
The grain diameter of the white carbon black is 10-100nm, and the purity is more than or equal to 99%.
The catalyst is one of chloroplatinic acid-polyvinyl silicone oil.
The inhibitor is natural aromatic compound, specifically 1-ethynyl-1-cyclohexanol, tetramethyl tetravinylcyclotetrasiloxane, 2-methyl-3-butynyl-2-ol and 3, 5-dimethyl-1-hexynyl-3-ol in any proportion.
A preparation method of an organic silicon foam medical dressing specifically comprises the following steps:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain a group B gel;
(3) Mixing the group A glue and the group B glue, stirring uniformly, and vulcanizing at 110 ℃ for 23min to obtain the organic silicon foam medical dressing.
Technical effects
Study of hemostatic action of Patch
1 test drugs
The products obtained in examples 1 and 2.
2 animals and Environment
SD rat, weight 200-220g, provided by Experimental animals center of Guangxi medical university, qualification: SCXK cinnamon 2014-0002. Animals were housed in air-conditioned rooms.
3 Experimental methods
30 mice weighing 18-22g, half of each male and female, were randomly divided into 3 groups, which were blank control group, patch group of example 1, patch group of example 2, and 10 mice each. The mice in each group are anesthetized by 10% chloral hydrate, the shaving area on the two sides of the spinal column is about 2cmx2cm, a surgical blade is used for scratching 1cmx1cm # on the skin to manufacture a bleeding wound surface, a blank medical adhesive plaster, the patch in example 1 and the patch in example 2 are immediately and respectively pasted on the bleeding wound surface, the patch is uncovered for observing the bleeding condition about 30S, the observation is carried out for 1 time every 30S, the bleeding stopping time is taken until the wound surface is not bled, and the bleeding stopping time is recorded. The results are shown in Table 1.
Table 1 effect of example 1 and example 2 patches on hemostasis of body surface wounds (± s, n = 10)
Group of | Hemostasis time(s) |
Blank control group | 246.02±12.07 |
Example 1 Patch | 192.04±19.55 |
EXAMPLE 2 Patch preparation | 185.51±13.60* |
Comparison with blank control: * P <0.05; * P <0.01
4 results
As can be seen from Table 1, the patches of examples 1 and 2 were statistically significantly different from the placebo group in that they were able to shorten the bleeding time on the surface wound (P <0.05, P < -0.01).
Adsorption seepage test
1 test drugs
The products obtained in examples 1 and 2.
2 method of experiment
Referring to the national medical industry Standard YY/T0471.1-2004 contact wound dressing test method part 1 of the liquid absorbability
Preparation of test solution: consists of a solution of sodium chloride and calcium chloride containing 142mmol of sodium ions and 2.5mmol of calcium ions. The ion content of the solution is equivalent to human serum or wound exudate. 8.298g of sodium chloride and 0.368g of calcium chloride dihydrate were dissolved in a volumetric flask with deionized water and diluted to 1L.
2.1 the silicone foam medical dressings obtained in examples 1 and 2 were cut into a size of 5cm × 5cm, precisely weighed, and placed in a petri dish, respectively.
2.2 test solutions preheated to 37. + -. 1 ℃ are added, the mass of which is 40 times that of the test material. + -. 0.5g.
2.3 move into the drying oven and keep it at 37 + -1 deg.C for 30min.
2.4 holding one corner or end of the sample with tweezers, hanging for 30s, precisely weighing
3 calculation of results
At a rate of per 100cm 2 The average mass of the dressing absorbing the solution represents the absorbed amount. The results are shown in tables 2 and 3.
Table 2: example 1 results of adsorption bleed test
Table 3 example 2 results of the adsorption bleed test:
4 conclusion
As can be seen from the above tables 2 and 3, the silicone foam medical dressings obtained in the examples 1 and 2 of the present invention have a certain function of absorbing seepage.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (9)
1. The medical organosilicon foam dressing is characterized by comprising the following raw materials in parts by weight: 90-110 parts of vinyl silicone oil, 20-60 parts of hydroxyl silicone oil, 0.1-4 parts of hydrogen-containing silicone oil, 10-40 parts of chitosan, 5-20 parts of sodium alginate, 10-50 parts of filler, 1-10 parts of white carbon black, 0.01-10 parts of inhibitor and 0.02-20 parts of catalyst.
2. The silicone foam medical dressing of claim 1, wherein the vinyl silicone oil is a vinyl terminated polydimethylsiloxane or a side vinyl polydimethylsiloxane; the vinyl silicone oil has a vinyl content of 0.01-2.89% and a viscosity of 200-150000mPa · s;
the hydroxyl silicone oil is hydroxyl-terminated silicone oil; the hydroxyl content of the hydroxyl silicone oil is 0.5-8.0%, and the viscosity is 25-100000mPa & s;
the hydrogen-containing silicone oil is terminal group type hydrogen-containing silicone oil or side chain type hydrogen-containing silicone oil; the hydrogen content of the hydrogen-containing silicone oil is 0.1-1.6%, and the viscosity is 5-3000mPa & s;
the pH value of the sodium alginate is 6.8-7.2, and the viscosity is less than or equal to 2000 mPa.
3. The silicone foam medical dressing according to claim 1, wherein the filler is methyl silicone resin or vinyl silicone resin.
4. The medical dressing of claim 1, wherein the white carbon black has a particle size of 10-100nm and a purity of 99% or more.
5. The silicone foam medical dressing of claim 1, wherein the catalyst is chloroplatinic acid-isopropanol complex, chloroplatinic acid-divinyltetramethyldisiloxane, chloroplatinic acid-tetramethyltetravinylcyclotetrasiloxane or chloroplatinic acid-polyvinylsilicone oil.
6. The silicone foam medical dressing of claim 1, wherein the inhibitor is a natural aromatic compound having a general structural formula of Cn H2 n-x or Cn H2 n-xOy, wherein x =2,4,6,8,10.
7. The silicone foam medical dressing of claim 6, wherein the natural aromatic compound is one or a combination of any of phenylacetylene, 1-ethynyl-1-cyclohexanol, tetramethyltetravinylcyclotetrasiloxane, 2-methyl-3-butynyl-2-ol, 3-methyl-1-ethynyl-3-ol, 3, 5-dimethyl-1-hexynyl-3-ol, and 3-methyl-1-dodecyn-3-ol.
8. The method of making a silicone foam medical dressing of any of claims 1-7, comprising the steps of:
(1) Uniformly mixing the vinyl silicone oil, the filling agent, the white carbon black, the hydrogen-containing silicone oil, the hydroxyl silicone oil and the inhibitor to obtain A group adhesive;
(2) Uniformly mixing the chitosan, the sodium alginate and the catalyst to obtain a group B gel;
(3) And mixing and stirring the group A glue and the group B glue uniformly, and vulcanizing to obtain the organic silicon foam medical dressing.
9. The method for preparing the silicone foam medical dressing according to claim 8, wherein in the step (3), the vulcanization temperature is 80-120 ℃, and the vulcanization time is 3-30min.
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