CN109680498A - A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion - Google Patents
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion Download PDFInfo
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- CN109680498A CN109680498A CN201910028636.XA CN201910028636A CN109680498A CN 109680498 A CN109680498 A CN 109680498A CN 201910028636 A CN201910028636 A CN 201910028636A CN 109680498 A CN109680498 A CN 109680498A
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- chitosan
- gauze
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- silver ion
- mixed liquor
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M11/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with inorganic substances or complexes thereof; Such treatment combined with mechanical treatment, e.g. mercerising
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
- D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
- D06M13/325—Amines
- D06M13/328—Amines the amino group being bound to an acyclic or cycloaliphatic carbon atom
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M15/00—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment
- D06M15/01—Treating fibres, threads, yarns, fabrics, or fibrous goods made from such materials, with macromolecular compounds; Such treatment combined with mechanical treatment with natural macromolecular compounds or derivatives thereof
- D06M15/03—Polysaccharides or derivatives thereof
- D06M15/13—Alginic acid or derivatives thereof
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- D—TEXTILES; PAPER
- D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
- D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
- D06M16/00—Biochemical treatment of fibres, threads, yarns, fabrics, or fibrous goods made from such materials, e.g. enzymatic
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- Textile Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
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Abstract
The present invention provides a kind of medical preparation methods for resisting antibacterial gauze of nanometer-level silver ion, it should be the preparation method comprises the following steps: (1) takes nano-silver ionic solution, chitosan degerming mixture is added, mechanical stirring is uniformly mixed, and the chitosan mixed liquor that mass concentration is 5-6% is made；(2) hospital gauze is impregnated in chitosan mixed liquor 5-6 hours, is uniformly distributed the chitosan mixed liquor containing nano-silver ionic in the gauze, using autoclaving processing a period of time after taking-up, obtain that nanometer-level silver ion is medical to resist antibacterial gauze；The invention discloses a kind of preparation method of medical anti-, the antibacterial gauze of nanometer-level silver ion, gained gauze has the function such as long-acting, potent, quick-acting anti-, suppression sterilizations.
Description
Technical field
The present invention relates to hospital gauze field of material technology, and in particular to a kind of nanometer-level silver ion is medical to resist antibacterial gauze
Preparation method.
Background technique
Gauze is medical institutions' required article, and consumption is very large, but hospital gauze traditional for many years is always to use
Common sterile gauze does not have anti-, bacteria resistance function, and the chemosterilant on common sterile gauze is mostly organic disinfectant,
It is easy to generate human body the side effects such as certain drug resistance.Requirement as medical technology is constantly innovated, for medical yarn
It correspondinglys increase, thus to having anti-, suppression sterilizing function gauze, it is essential in medical institutions.
Nanometer-level silver ion has antibacterial more superior than general chemistry silver due to having zoic special construction and performance
Activity, the silver ion of 250 μ g/ml of content can quickly kill bacterium, and sterilizing rate is up to 99.99%, and broad-spectrum antiseptic promotes wound
Mouthful healing, it is nontoxic to the human body, nonirritant, the side effects such as have no drug resistance.
With going deep into researching wound healing, it was recognized that being run far deeper than using the purpose of dressing is to cover wound
Face, dressing must also can promote wound healing.Pervious viewpoint thinks to be as far as possible wound one dry environment of creation,
With the healing for reducing infection chance, being conducive to wound.But recent studies indicate that, the wound healing in wet environment
Faster.When causing defect of skin due to factors such as damage or diseases, often results in surface of a wound moisture, electrolyte and protein and lose
It loses, the open surface of a wound also adds the probability of infection, and the generation of above-mentioned complication can be reduced by being effectively sealing off the surface of a wound in early days.
A kind of chitosan using organic pressure-sensitive gel is disclosed in patent document CN103690301A disclosed in the China
Dressing is made of chitosan gauze, silicone pressure sensitive glue-line and release film；Chitosan gauze is to be coated on chitosan particle
Gauze body upper surface is prepared；Silicone pressure sensitive glue-line is to be coated in organic pressure-sensitive gel on non-woven fabrics matrix to prepare shape
At；The non-woven fabrics matrix of silicone pressure sensitive glue-line is incorporated on the gauze matrix of chitosan gauze.The chitosan particle of the invention
Can inhibit fibroblastic growth, to prevent scar from being formed, improve the healing of wound high quality, and organic pressure-sensitive gel
Wound is not glued when removing, and cambium will not be caused to damage；Soft comfortable when being pasted on wound, does not have pain when removing
Sense.The chitosan dressing of the invention can be used for chronic wounds such as bedsore, leg ulcer of foot, traumatic wounds knife incised wound, burn and scald, friction
Wound, the nursing and dressing of the wounds surface of a wound such as each section's wound.
But the hospital gauze material provided in the prior art there is also anti-microbial properties limited, the poor defect of anthemorrhagic performance.
Summary of the invention
Aiming at the problems existing in the prior art, resist antibacterial gauze the present invention provides a kind of nanometer-level silver ion is medical
Preparation method effectively compensates for defect of the existing technology.
The present invention uses methylene chloride to substitute original concentrated sulfuric acid as solvent, and reaction temperature is mild, improves nitration reaction
Safety aoxidizes the by-product sulfuric acid of generation, can recycled again, reduce the yield of by-product acid, to reduce ring
Border pollution, and improve product yield and quality.
In order to achieve the above object, the present invention is achieved by the following technical programs:
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, the preparation method include the following steps:
(1) it prepares chitosan mixed liquor: taking nano-silver ionic solution, chitosan degerming mixture is added, mechanical stirring is mixed
Close the chitosan mixed liquor for being uniformly made that mass concentration is 5-6%；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine；
(2) hospital gauze is impregnated in chitosan mixed liquor 5-6 hours, mixes the chitosan containing nano-silver ionic
Liquid is uniformly distributed in the gauze, and using autoclaving processing a period of time after taking-up, it is medical anti-to obtain nanometer-level silver ion
Antibacterial gauze.
Preferably, the granular size of nano-silver ionic is 5-7nm in step (1).
Preferably, the mass concentration of silver ion is 250 μ g/ml in nano-silver ionic solution in step (1).
Preferably, the mass ratio of chitosan, sodium alginate and n-octyl amine is 2 in chitosan degerming mixture in step (1):
1:1。
Preferably, mechanical stirring speed is 240-250r/min in step (1).
Preferably, step (2) the mesohigh steam sterilization processing time is 10-15min.
The beneficial effects of the present invention are:
After sodium alginate is contacted with wound fluid, ion exchange occurs with the Na+ in blood, becomes hydrogel and is attached to
Wound surface plays the role of protection to wound in order to avoid infection to forming layer protecting film, can also provide one it is wet
Environment facilitates wound healing；N-octyl amine is introduced on sodium alginate skeleton, can be improved its performance well, it is effective to increase
Add drug loading and controlled release approach, to be conducive to the performance of medicine effect.Chitosan can increase sea in conjunction with inorganic material
The tensile property of mosanom improves the water absorption rate of dressing, after contacting blood, fibrin ferment can be released, in conjunction with calcium ion
The bleeding time is shortened in effect, reduces amount of bleeding, forms gel overlay in the healing on wound, promoting wound.
Contain 250 μ g/ml of nanometer-level silver ion in solution of the present invention, have stronger, quick-acting wide spectrums are anti-, suppression kill it is a variety of thin
Bacterium, and resist more by force, press down the functions such as bactericidal.In order to allow silver ion to be not easy to fall off from gauze, special addition is sticking
Silver ion is uniformly bonded in gauze by 5% chitosan using dip finishing technique, has been obtained stronger, quick-acting, wide spectrum and has been resisted, presses down
The long-acting sterilization functions gauzes such as sterilization, and have no drug resistance safely.Meet the anti-suppression bactericidal gauze of medical institutions' requirement.
Specific embodiment
In order to keep the purposes, technical schemes and advantages of the embodiment of the present invention clearer, implement below in conjunction with the present invention
Technical solution in example carries out clear, complete description, it is clear that and described embodiment is section Example of the invention, and
It is not all of embodiment.Based on the embodiment of the present invention, those of ordinary skill in the art are not before making the creative labor
Every other embodiment obtained is put, protection scope of the present invention is belonged to.
Embodiment 1:
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, the preparation method include the following steps:
(1) it prepares chitosan mixed liquor: 5nm nanometers of 0.25g silver ions being taken to be added to 1000ml chitosan degerming mixture
Solution in, be uniformly mixed with the revolving speed machinery of 240r/min, be made mass concentration be 5% chitosan mixed liquor；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine, chitosan, seaweed
The mass ratio of sour sodium and n-octyl amine is 2:1:1；
(2) hospital gauze is impregnated in chitosan mixed liquor 6 hours, makes the chitosan mixed liquor containing nano-silver ionic
It is uniformly distributed in the gauze, 15min is handled using autoclaving after taking-up, obtains that nanometer-level silver ion is medical to resist antibacterial yarn
Cloth.
Embodiment 2:
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, the preparation method include the following steps:
(1) it prepares chitosan mixed liquor: 6nm nanometers of 0.25g silver ions being taken to be added to 1000ml chitosan degerming mixture
Solution in, be uniformly mixed with the revolving speed machinery of 240r/min, be made mass concentration be 6% chitosan mixed liquor；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine, chitosan, seaweed
The mass ratio of sour sodium and n-octyl amine is 2:1:1；
(2) hospital gauze is impregnated in chitosan mixed liquor 5 hours, makes the chitosan mixed liquor containing nano-silver ionic
It is uniformly distributed in the gauze, 10min is handled using autoclaving after taking-up, obtains that nanometer-level silver ion is medical to resist antibacterial yarn
Cloth.
Embodiment 3:
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, the preparation method include the following steps:
(1) it prepares chitosan mixed liquor: 5nm nanometers of 0.25g silver ions being taken to be added to 1000ml chitosan degerming mixture
Solution in, be uniformly mixed with the revolving speed machinery of 250r/min, be made mass concentration be 5% chitosan mixed liquor；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine, chitosan, seaweed
The mass ratio of sour sodium and n-octyl amine is 2:1:1；
(2) hospital gauze is impregnated in chitosan mixed liquor 6 hours, makes the chitosan mixed liquor containing nano-silver ionic
It is uniformly distributed in the gauze, 15min is handled using autoclaving after taking-up, obtains that nanometer-level silver ion is medical to resist antibacterial yarn
Cloth.
Embodiment 4:
A kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, the preparation method include the following steps:
(1) it prepares chitosan mixed liquor: 7nm nanometers of 0.25g silver ions being taken to be added to 1000ml chitosan degerming mixture
Solution in, be uniformly mixed with the revolving speed machinery of 250r/min, be made mass concentration be 6% chitosan mixed liquor；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine, chitosan, seaweed
The mass ratio of sour sodium and n-octyl amine is 2:1:1；
(2) hospital gauze is impregnated in chitosan mixed liquor 5 hours, makes the chitosan mixed liquor containing nano-silver ionic
It is uniformly distributed in the gauze, 10min is handled using autoclaving after taking-up, obtains that nanometer-level silver ion is medical to resist antibacterial yarn
Cloth.
By gauze obtained by the embodiment of the present invention and gauze in the prior art, wound is wrapped up respectively, tests its performance,
The result is as follows:
| Infect probability/% | Bleeding stopping period/min | Healing time/day | |
| Embodiment 1 | 5 | 1 | 4 |
| Embodiment 2 | 5 | 1 | 4 |
| Embodiment 3 | 4 | 1 | 4 |
| Embodiment 4 | 5 | 1 | 4 |
| Existing gauze | 35 | 3 | 7 |
As seen from the above table, present invention gained gauze compare with the gauze that provides in the prior art, have anti-infective well
Performance (antibacterial action is strong), hemostasis is fast, and wound healing time is short.
It should be understood that for those of ordinary skills, it can be modified or changed according to the above description,
And all these modifications and variations should all belong to the protection domain of appended claims of the present invention.
Claims (6)
1. a kind of medical preparation method for resisting antibacterial gauze of nanometer-level silver ion, which is characterized in that the preparation method includes as follows
Step:
(1) it prepares chitosan mixed liquor: taking nano-silver ionic solution, chitosan degerming mixture is added, mechanical stirring mixing is equal
It is even, the chitosan mixed liquor that mass concentration is 5-6% is made；
Wherein, the constituent of chitosan degerming mixture is chitosan, sodium alginate and n-octyl amine；
(2) hospital gauze is impregnated in chitosan mixed liquor 5-6 hours, keeps the chitosan mixed liquor containing nano-silver ionic equal
It is even distribution in the gauze, after taking-up using autoclaving processing a period of time, obtain nanometer-level silver ion it is medical resist it is antibacterial
Gauze.
2. the medical preparation method for resisting antibacterial gauze of nanometer-level silver ion according to claim 1, which is characterized in that described
The granular size of nano-silver ionic is 5-7nm in step (1).
3. the medical preparation method for resisting antibacterial gauze of nanometer-level silver ion according to claim 1, which is characterized in that described
The mass concentration of silver ion is 250 μ g/ml in nano-silver ionic solution in step (1).
4. the medical preparation method for resisting antibacterial gauze of nanometer-level silver ion according to claim 1, which is characterized in that described
The mass ratio of chitosan, sodium alginate and n-octyl amine is 2:1:1 in chitosan degerming mixture in step (1).
5. the medical preparation method for resisting antibacterial gauze of nanometer-level silver ion according to claim 1, which is characterized in that described
Mechanical stirring speed is 240-250r/min in step (1).
6. the medical preparation method for resisting antibacterial gauze of nanometer-level silver ion according to claim 1, which is characterized in that described
Step (2) mesohigh steam sterilization handles the time as 10-15min.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111364232A (en) * | 2020-03-27 | 2020-07-03 | 石狮市致高纺织实业有限公司 | Antibacterial and mildewproof cotton fabric and preparation process thereof |
| CN111544202A (en) * | 2019-09-29 | 2020-08-18 | 华中科技大学同济医学院附属协和医院 | Self-adhesive gauze and preparation method thereof |
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| CN103046162A (en) * | 2013-01-21 | 2013-04-17 | 海南大学 | Preparation method of modified sodium alginate electrospun nanofibers |
| CN105107008A (en) * | 2015-09-16 | 2015-12-02 | 中南民族大学 | Hydroxybutyl chitosan/oxidized sodium alginate/nano-silver composite hydrogel dressing plaster |
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| CN111364232A (en) * | 2020-03-27 | 2020-07-03 | 石狮市致高纺织实业有限公司 | Antibacterial and mildewproof cotton fabric and preparation process thereof |
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Application publication date: 20190426 |