CN109010907B - A kind of functionality Wound-protection liquid body dressing and preparation method thereof - Google Patents
A kind of functionality Wound-protection liquid body dressing and preparation method thereof Download PDFInfo
- Publication number
- CN109010907B CN109010907B CN201810992151.8A CN201810992151A CN109010907B CN 109010907 B CN109010907 B CN 109010907B CN 201810992151 A CN201810992151 A CN 201810992151A CN 109010907 B CN109010907 B CN 109010907B
- Authority
- CN
- China
- Prior art keywords
- quaternary ammonium
- wound
- dressing
- ammonium salt
- liquid body
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0076—Sprayable compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/224—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials containing metals, e.g. porphyrins, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention provides a kind of functional Wound-protection liquid body dressing, including following component: chitosan quaternary ammonium salt 23-65%, organosilicon quaternary ammonium salt 18-50%, double-chain quaternary ammonium salt 15-46%, Sodium Hyaluronate 1-6%, vitamin B12 0.6-2%.Fluid present invention dressing is a kind of aerosol type molecular level stealth dressing, dressing formula is reasonable, each ingredient mutually merges, curative effect can be significantly improved using functional Wound-protection liquid body dressing of the invention, the pain degree for reducing patient, reduces the number of dressing, shortens the time of recovery from illness, with apparent advantage, it is worth clinical application.
Description
Technical field
The present invention relates to medical dressing technical field, in particular to a kind of functional Wound-protection liquid body dressing and its preparation side
Method.
Background technique
Infection is the disturbing factor of wound healing process most serious, is mainly manifested in the epithelial tissue for damaging remaining and postpones
Healing time, when pyemia occurs, epithelial growth can stop.So-called " pyemia " refers to by the different microorganisms of intrusion wound
It is proliferated and generates harmful toxicant, serious person can cause systemic toxicity profiles to react and threat to life.Inflammatory reaction is that wound is cured
The basis of conjunction, but excessive inflammatory reaction can be led to the necrosis of local organization cell, and the tissue of necrosis is that wound is hindered to be cured
The factor of conjunction, and if control may also result in systemic infection not in time, the in this way difficulty of wound healing more again, very
To being in peril of one's life, such as diabetic foot ulcer, pressure sore chronic wound, the surface of a wound is easy to settle down for bacterial clump, breeding, sometimes
Still be fungi or other microorganisms, this may be chronically exposed to due to the surface of a wound it is outer, be easy to pollute it is therefore, in addition other factors are such as
Poor blood supply, anoxic are also beneficial to the colonization of bacterium.It is abnormal caused by wound infection, mainly collagenic supersession disorder, infection
After area neutrophil phagocytosis bacterium, the protease and oxygen radical of release can destroy tissue, and making collagenolysis is more than deposition, draw
Play wounds delay healing.In the presence of infection, bacterium and inflammatory cell increase oxygen and the consumption of other nutriment, fibroblast metabolism
It is impaired, and there are many exudate after infection, increase wound localised tension, cause wound dehiscence.
In order to anti-infective, in wound using the phenomenon that antibiotic clinical commonplace.In fact, antibiotic is locally answered
With being also easy to produce antibody-resistant bacterium, and antibiotic, in wound surface concentration highest, in wound deep, concentration is progressively lower, and antibacterial effect is not achieved
Fruit is also easy to produce drug resistance instead.Another serious problems of antibiotic topical application are that contact allergy is caused to be reacted, especially for a long time
It is widely used in more obvious when chronic wounds.The application of some antibiotic can impair wound cells proliferation and epithelium is formed, and kill
Extremely it is beneficial to the macrophage (effect of commander-in-chief is equivalent in wound healing process) of healing, so, it does not mention typically
Topical application antibiotic is advocated, especially injection antibiotic should more forbid topical application.
Current clinically common traditional dressing has various gauzes, cotton pad etc..Traditional dressing is at low cost, and raw material sources are wide
It is general, it is soft, there is stronger absorbability and can prevent wound exudate from gathering, has certain protective effect to the surface of a wound, so far
Still it is widely applied in various types of wounds.But with further understanding and requiring to wound healing, traditional dressing day
Benefit shows its limitation.Petrolatum gauze is a kind of traditional dry dressing, and production is simple, can protect wound to a certain extent
Face has gas permeability and certain hygroscopicity.But the vaseline ingredient in dressing has certain stimulation to the surface of a wound；Dressing table
Face is coarse, dry, and the surface of a wound that easily rubs causes to damage；The surface of a wound newly granulates and easily grows into the mesh of dressing, and when dressing causes to ache
Pain simultaneously damages the surface of a wound；Petrolatum gauze absorbability is poor, oozes out more patient for the surface of a wound and is not easily accepted by.
Clinically common synthetic dressing has film-type and foam type etc..Film dressing is the one side in bio-medical film
Painting is covered with pressure sensitive adhesive and is formed, and internal layer hydrophilic material can absorb wound exudate, and cladding material then has good gas permeability
And elasticity.Such dressing appearance transparent, convenient for observation；It can maintain the surface of a wound wet after use, necrotic tissue is promoted to fall off.But dressing
It easily causes sepage under film to gather after absorbing saturation, may induce or aggravate infection, therefore be only applicable to the surface of a wound of relative clean, be unsuitable for
Exudative and infective wound surface.Foam type dressing has porosity, has biggish absorptive capacity to liquid.Such dressing is to wound
Face has good protective effect, and heat preservation, moisture-retaining capacity are stronger, and dressing is lighter, and the patient feels are more comfortable.But some dressing is because viscous
Patch property is poor and needs external fixation system；Dressing is generally opaque, it is difficult to observe surface of a wound situation；Dressing hole is big, wound granulation group
It knits and easily grows into, it is difficult to cause demoulding, and vulnerable to germ contamination.
From the perspective of hospital, traditional dressing due to not having the functions such as treatment, reparation, in clinic application range by
To limitation.And with the quickening pace of modern life and the increasing of operating pressure, when people prefer to that wound healing can be shortened
Between, medical dressing dosage is reduced, nursing time is greatly shortened.
Summary of the invention
Mirror, the object of the present invention is to provide a kind of antibacterial, hemostasis, is relieved pain with this, prevents adhesion, and wound can be promoted to be cured
Close, reduce the formula and preparation method of the functional Wound-protection liquid body dressing of scar.
The technical scheme is that
A kind of functionality Wound-protection liquid body dressing, by mass percentage, the solid material containing 0.26-0.5%, surplus is
Water, wherein the solid material includes following component: chitosan quaternary ammonium salt 23-65%, organosilicon quaternary ammonium salt 18-50%, it is double
Chain quaternary ammonium salt 15-46%, Sodium Hyaluronate 1-6%, vitamin B12 0.6-2%, the sum of solid material each component are 100%.
Preferably, the functional Wound-protection liquid body dressing, by mass percentage, containing 0.3% solid material, surplus
For water, wherein the solid material includes following component: chitosan quaternary ammonium salt 27.4%, organosilicon quaternary ammonium salt 20%, double-strand
Quaternary ammonium salt 46%, Sodium Hyaluronate 6%, vitamin B12 0.6%, the sum of solid material each component are 100%.
It is furthermore preferred that the molecular weight of the Sodium Hyaluronate is 50~2000kDa.
It is furthermore preferred that the molecular weight of the Sodium Hyaluronate is 100kDa.
The present invention also provides the preparation methods of the functional Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6~10%；It will be saturating
Bright matter acid sodium and vitamin B12 are dissolved in water；
2) water is added in agitator tank, mixing speed is 15~25 revs/min, and chitosan quaternary ammonium salt and double-strand season is first added
Ammonium salt makes it completely dissolved, and the time 1~2 hour；
3) 6~10% organosilicone quaternary ammonium salting liquids of step 1) preparation are added while stirring again, are sufficiently stirred 2~3 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 30~50 revs/min, is sufficiently stirred, the time 3~4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.26~0.5%, semi-finished product of the pH value 4.8~7.2, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Preferably, in step 1), the mass concentration of organosilicone quaternary ammonium salting liquid is 6%.
Preferably, in step 5), pH value 6.8.
Preferably, in step 1), after Sodium Hyaluronate and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is
35℃。
" organosilicon quaternary ammonium salt " in functionality Wound-protection liquid body dressing main component of the invention is a kind of novel cation table
Face activating agent.With lubricity, levelling and permeability are applied, there are also powerful bactericidal properties, can effectively inhibit G+Bacterium, G-Bacterium, ferment
Female bacterium.Its sterilization mechanism is: being mediated with organosilicon, ammonium cation group with bactericidal property is forcefully adsorbed in carefully
The surface of bacterium changes the permeability of bacteria cell wall, overflows endobacillary enzyme, coenzyme and metabolic intermediate, causes micro- life
Object ceases breathing function and lethal, to have the function that sterilization, antibacterial, that is, " contact is dead " has occurred.
Chitosan quaternary ammonium salt is that a low molecule quaternary ammonium salt is connected on chitosan 2 amino, and water solubility compares crust
Matter and chitosan are good.Chitosan quaternary ammonium salt enhances the electropositive of chitosan, there is its anti-microbial property than chitosan or doped quaternary ammonium salt
Greatly improve, and overcome chitosan only just there is the deficiency of restraining and sterilizing bacteria effect in acid condition, make its it is acid,
Good antibacterial effect is all played under neutral, alkaline condition.Not only with the property of typical quaternary ammonium salt, such as bacteria resistance and
Moisture absorbability and moisture retentivity, and maintain the original good film forming of chitosan, flocculability, wound healing, biocompatibility
With the performances such as biodegradability.
Double-chain quaternary ammonium salt is with " double certain herbaceous plants with big flowers methyl ammoniums " for representative, its advantage is that Disinfection Effect is reliable, stability is good,
It is non-stimulated to skin and mucosa, chemical property stablize, can long term storage, it is not volatile, it is corrosion-free to sterilizing objects, noresidue poison
Evil.It is a kind of cationic surfactant, and bactericidal effect changes first is that permeability barrier by destroying somatic cells surface
Attenuate the permeability of born of the same parents, ruptures thallus, second is that inhibiting or destroying the activity of desmoenzyme, and causes microorganism dead.It can be effective
Kill the microorganisms such as bacterial propagule, fungi, lipophilic virus.Double-chain quaternary ammonium salt is mainly used for environmental surfaces and sterilisation of objects such as skin
Skin mucous membrane sterilizing.
Sodium Hyaluronate is a kind of acid mucopolysaccharide, isolates the substance from bovine vitreous body first, and hyaluronic acid is
A kind of intrinsic ingredient, is a kind of glucan aldehydic acid in human body, and without species specificity, it is widely present in placenta, and amniotic fluid is brilliant
Shape body, articular cartilage, the tissue such as dermal layer of the skin；It is distributed in cytoplasm in organ, in cytoplasm, to contained therein thin
Born of the same parents and organelle itself play lubrication and nourishing effect, while providing the microenvironment of cell metabolism, it is that a kind of human body is natural
" hyaluronic acid " cooperation with other promote cytothesis smoothing wrinkle drugs a kind of gel is made, used by injecting method.It is transparent
Matter acid sodium can promote injury skin by the proliferation of promotion epidermal cell and differentiation and the effect of scavenging activated oxygen
Regeneration.Sodium Hyaluronate, egf and heparin are used cooperatively, the regeneration of epidermal cell can be accelerated, keeps skin delicacy smooth, it is rich
It is flexible.When skin is by slight burn and scald, the aqua cosmetics containing Sodium Hyaluronate are smeared on surface can reduce pain, accelerate
The healing of injury skin.
Vitamin B12 is called cobalamin, is vitamin uniquely containing metallic element.Commonly referred to as hematopoiesis vitamin, tool
There is the regenerated superior effect of skin, cytothesis and hematopoiesis all can't do without it, be the important components for promoting human metabolism.It can
Easily to solve the problems, such as following skin: the problems such as skin is tired out, obscure, dry skin；Produced by obvious desalination increases because of the age
Microgroove and wrinkle；After maintenance solarization, skin caused by the autumn and winter are dry and cold etc. is red and swollen, decortication, pain；Acne scar mark, mosquito are bitten
Scar, empyrosis scar；It is used after cosmetic surgery, it can be to avoid scar.
Compared with prior art, the beneficial effects of the present invention are:
A. fluid present invention dressing is a kind of aerosol type molecular level stealth dressing, and dressing formula is rationally, synergistic, respectively at
Split-phase mutually merges, and forms QAS polymer, when solution spraying is after skin or surface of a wound surface, i.e., in skin or surface of a wound formation one
Layer stablizes fine and close positively charged reticular membrane, has extremely strong absorption to microorganisms such as negatively charged bacterium, fungi, viruses
Effect, the respiratory enzyme for causing pathogen to depend on for existence is ineffective and death by suffocation, plays physical sterilization or bacteriostasis, simultaneously
Infection can also be isolated.Fluid present invention dressing has the function of broad-spectrum antiseptic, promotes healing, reduces scar, and to clinically
The difficult healedmyocardial surface of a wound also has good therapeutic effect.
B. the present invention be suitable for any shape infection face or the surface of a wound, the surface of a wound that traditional dressing is not fixed easily: hand, foot,
The positions such as joint, Hui Yin, genitals, fluid present invention functional dressing have good adaptability；In use process, glue can be not necessarily to
Cloth is fixed, and the secondary damage of surface of a wound dressing is reduced, to significantly reduce the pain of patient.
C. transparent membrane is formed after the functional Wound-protection liquid body dressing spray drying of the present invention, makes one mesh of healing state of the surface of a wound
It is clear, the surface of a wound for not needing wrapping can directly observe wound repair situation after fluid present invention dressing.
D. the functional Wound-protection liquid body dressing of the present invention can significantly improve curative effect, reduce the pain degree of patient, reduce dressing
Number, shorten the time of recovery from illness, have apparent advantage, be worth clinical application.
E. the preparation method of liquid dressing provided by the present invention, for each component chemical property and design, rationally adjust
The technological parameter of the adding order of whole each component and each step keeps liquid dressing performance of the invention more stable, therapeutic effect
More preferably.
Specific embodiment
In order to be best understood from the technology of the present invention content, specific embodiment is provided below, the present invention is described further.
Embodiment 1
A kind of functionality Wound-protection liquid body dressing, by mass percentage, containing 0.26% solid material, surplus is water,
In, the solid material includes following component: chitosan quaternary ammonium salt 23%, organosilicon quaternary ammonium salt 50%, double-chain quaternary ammonium salt
19%, Sodium Hyaluronate (molecular weight 50kDa) 6%, vitamin B12 2%, the sum of solid material each component is 100%.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6%, by hyalomitome
After sour sodium and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is 35 DEG C.
2) suitable quantity of water is added in agitator tank, sets blender mixing speed as 25 revs/min, chitosan quaternary ammonium is first added
Salt and double-chain quaternary ammonium salt, make it completely dissolved, and the time 1 hour；
3) 6% organosilicone quaternary ammonium salting liquid of step 1) preparation is added while stirring again, is sufficiently stirred 2 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 30 revs/min, is sufficiently stirred, the time 4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.26%, semi-finished product of the pH value 7.2, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Embodiment 2
A kind of functionality Wound-protection liquid body dressing, by mass percentage, containing 0.5% solid material, surplus is water,
In, the solid material includes following component: chitosan quaternary ammonium salt 65%, organosilicon quaternary ammonium salt 18%, double-chain quaternary ammonium salt
15%, Sodium Hyaluronate (molecular weight 2000kDa) 1%, vitamin B12 1%, the sum of solid material each component is 100%.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6%, by hyalomitome
After sour sodium and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is 35 DEG C.
2) water is added in agitator tank, sets blender mixing speed as 25 revs/min, be first added chitosan quaternary ammonium salt and
Double-chain quaternary ammonium salt makes it completely dissolved, and the time 1 hour；
3) 6% organosilicone quaternary ammonium salting liquid of step 1) preparation is added while stirring again, is sufficiently stirred 2 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 30 revs/min, is sufficiently stirred, the time 4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.5%, semi-finished product of the pH value 4.8, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Embodiment 3
A kind of functionality Wound-protection liquid body dressing, by mass percentage, containing 0.3% solid material, surplus is water,
In, the solid material includes following component: chitosan quaternary ammonium salt 27.4%, organosilicon quaternary ammonium salt 20%, double-chain quaternary ammonium salt
46%, Sodium Hyaluronate (molecular weight 100kDa) 6%, vitamin B12 0.6%, the sum of solid material each component is 100%.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6%, by hyalomitome
After sour sodium and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is 35 DEG C.
2) water is added in agitator tank, sets blender mixing speed as 25 revs/min, be first added chitosan quaternary ammonium salt and
Double-chain quaternary ammonium salt makes it completely dissolved, and the time 1 hour；
3) 6% organosilicone quaternary ammonium salting liquid of step 1) preparation is added while stirring again, is sufficiently stirred 2 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 30 revs/min, is sufficiently stirred, the time 4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.3%, semi-finished product of the pH value 6.8, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Embodiment 4
A kind of functionality Wound-protection liquid body dressing, the proportion of each component are same as Example 3.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 10%, by hyalomitome
After sour sodium and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is 35 DEG C.
2) water is added in agitator tank, sets blender mixing speed as 15 revs/min, be first added chitosan quaternary ammonium salt and
Double-chain quaternary ammonium salt makes it completely dissolved, time 2 h；
3) 10% organosilicone quaternary ammonium salting liquid of step 1) preparation is added while stirring again, is sufficiently stirred 3 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 50 revs/min, is sufficiently stirred, the time 3 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.3%, semi-finished product of the pH value 7.0, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Embodiment 5
A kind of functionality Wound-protection liquid body dressing, the proportion of each component are same as Example 3.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6%, by hyalomitome
Sour sodium and vitamin B12 are dissolved in water；
2) water is added in agitator tank, sets blender mixing speed as 25 revs/min, be first added chitosan quaternary ammonium salt and
Double-chain quaternary ammonium salt makes it completely dissolved, and the time 1 hour；
3) 6% organosilicone quaternary ammonium salting liquid of step 1) preparation is added while stirring again, is sufficiently stirred 2 hours；
4) Sodium Hyaluronate of step 1) preparation and the aqueous solution of vitamin B12, setting blender stirring are finally added
Speed is 30 revs/min, is sufficiently stirred, the time 4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measures solid content
0.3%, semi-finished product of the pH value 6.9, after Sterility testing is qualified, bottle body is dispensed, as finished product.
Embodiment 6
A kind of functionality Wound-protection liquid body dressing, the proportion of each component are same as Example 3.
The preparation method of the functionality Wound-protection liquid body dressing, comprising the following steps: press formula ratio, weigh each solid material
And water, mixing stir evenly, and after Sterility testing is qualified, bottle body packing, as finished product.
Comparative example 1
A kind of functionality Wound-protection liquid body dressing, by mass percentage, containing 1% solid material, surplus is water, wherein
The solid material includes following component: chitosan quaternary ammonium salt 10%, organosilicon quaternary ammonium salt 60%, double-chain quaternary ammonium salt
19.5%, Sodium Hyaluronate (molecular weight 100kDa) 10%, vitamin B12 0.5%, the sum of solid material each component is
100%.
The preparation method of the functionality Wound-protection liquid body dressing, it is same as Example 3.
Test example 1:
The past health row debridement and suturing patient 800 that 1.1 Object Selections are gone to a doctor in clinical hospitals emergency surgery,
Age 10-64 (average 43) years old, wherein facial injury 130, upper limb wound 330, lower limb injury 340.It is randomly divided into 8
Group, experimental group 1~6 use the liquid dressing of Examples 1 to 6, and control group 1 uses the liquid dressing of comparative example 1.Each group patient exists
Age, gender, disease etc. analyze no difference of science of statistics (P > 0.05).
1.2 method
1.2.1 experimental group removes surface of a wound foreign matter or dirt, is wiped 2 times with 0.5% iodophor disinfection solution, each 3-5min
Afterwards, the thimerosal on the surface of a wound is washed away with 0.9% physiological saline, is irrigated with hydrogen peroxide solution, then rushed with 0.9% physiological saline
Thimerosal is removed, by asptic technique, necrotic tissue is cut off, carries out suture.After operation, by functional liquid dressing of the present invention
Solution is uniformly sprayed on wound, is covered with sterile gauze, immobilization with adhesive tape.Dressing change frequency is determined according to wound situation, until wound
Mouth healing is intact.
1.2.2 control group 1 with 1.2.1 method, but using comparative example 1 dressing.
1.2.3 control group 2 but does not spray fluid present invention dressing with the method for 1.2.1, using routine disinfection.
1.3 observation index patient wound's first intention times, dressing change frequency, infection rate.
1.4 statistical procedures
2, result
Patient wound's first intention time, dressing change frequency, infection rate, which compare, sees Tables 1 and 2
1 primary wound healing time of table, dressing change frequency compare (x ± s)
| Group | Number of cases | Healing time (D) | Dressing change frequency (secondary) |
| Experimental group 1 | 100 | 3.27±2.12 | 2.01±0.46 |
| Experimental group 2 | 100 | 3.10±2.10 | 2.20±1.11 |
| Experimental group 3 | 100 | 2.21±2.54 | 1.05±0.47 |
| Experimental group 4 | 100 | 4.04±2.22 | 3.05±0.25 |
| Experimental group 5 | 100 | 5.24±2.40 | 3.14±0.85 |
| Experimental group 6 | 100 | 5.82±2.45 | 3.88±0.74 |
| Control group 1 | 100 | 7.33±2.47 | 5.29±1.55 |
| Control group 2 | 100 | 7.84±2.63 | 6.27±1.47 |
2 infection rate of table compares
3, interpretation of result
As can be seen that using routine disinfection solution from table 1, table 2, healing time is long, and dressing change frequency is more, infection rate
Height, statistical analysis have apparent statistical significance (P < 0.01), using fluid present invention dressing significantly reduce dressing change frequency,
Healing time, infection rate substantially reduce.
Test example 2
1.1 clinical data abdominal post-operation liquefied fats patient 400, male 230, female 170.Age 20~50
Year, average (36.51 ± 7.12) year.Subtotal gastrectomy 89, proctectomy 45, cholecystectomy 60, Cesarean esction
104, uterectomy 41, Appendectomy 61.Average cuts area 7.1cm × 2.3cm, clinical manifestation are postoperative
There is yellow sepage in (5.13 ± 1.78) d, and is mixed with fat drop.Patient is divided into 8 groups at random, implementation is respectively adopted in observation group
The dressing of example 1~6, control group 1 use the liquid dressing of comparative example 1, and each group Gender, disease, size incision, faces at the age
Bed performance etc. comparing difference is not statistically significant (P > 0.05), is comparable.
1.2 method
1.2.1 observation group is sprayed on the basis of routine care using the functional Wound-protection liquid body dressing of the present invention,
Patient incision's surrounding skin smear washing using iodine solution first, the most obvious and serious place of patient's liquefaction of fat into
Row is taken out stitches, and is cut off surrounding necrotic tissue, is cleaned with physiological saline cotton balls, and cleaning is finished is dried with sterile gauze.To routine
After processing is completed, notch and surrounding skin are sprayed with functional Wound-protection liquid body dressing of the invention, 3-5 spray/time, it is thorough
After the sprinkling of bottom, then the drainage of row Conventional filler, it is applied with sterile gauze and is fixed, dressing frequency is determined according to the case where wound extravasating
It is fixed, generally 1 time/d or 2~3 times/week.
1.2.2 control group 1 is treated using the dressing of comparative example 1.
1.2.3 control group 2 is treated using traditional dressing.
1.3 evaluation method
1.3.1 therapeutic effect observes and records wound healing situation after patient treats 1 week, and healing situation is divided into 3 grades, fullys recover from an illness
More: notch all healed；Effective: wound extravasating significantly reduces, and granulation growth is normal；Invalid: wound extravasating does not have without reduction
Grow granulation.
1.3.2 when treatment condition observes and records patient from first dressing to the dressing change frequency during fully recovering of leaving hospital, recovery from illness
Between, pain degree.Pain degree is divided into 4 grades: 0 point, pain is not present in when dressing；1 point, there is pain in when dressing, but not shadow
Ring sleep；2 points, there is obvious pain in when dressing, causes certain interference to sleep；3 points, when dressing, has an intense pain, and sleeps necessary
By analgestic.
1.4 statistical procedures
2 results
2.1 patient outcomes compare
3 therapeutic effect of table compares
| Group | Number of cases | Recovery from illness | It is effective | In vain | Effective percentage/% |
| Observation group 1 | 50 | 31 | 15 | 4 | 92% |
| Observation group 2 | 50 | 30 | 16 | 4 | 92% |
| Observation group 3 | 50 | 36 | 13 | 1 | 98% |
| Observation group 4 | 50 | 29 | 16 | 5 | 90% |
| Observation group 5 | 50 | 30 | 14 | 6 | 88% |
| Observation group 6 | 50 | 29 | 14 | 7 | 86% |
| Control group 1 | 50 | 25 | 13 | 12 | 76% |
| Control group 2 | 50 | 20 | 16 | 14 | 72% |
2.2 patient's cure times, dressing change frequency, pain degree compare
4 cure time of table, dressing change frequency, pain degree compare (x ± s)
3 interpretations of result
From table 3, table 4 as can be seen that compared with the control group, present invention functionality Wound-protection liquid body dressing can significantly improve treatment
Effect, reduces the pain degree of patient, reduces the number of dressing, shorten the time of recovery from illness, has apparent advantage, and worth clinic pushes away
Wide application.This is mainly due to functional protective dressings of the invention to be sprayed to the surface of a wound, and it is attached can to form molecular level physical antiseptic film
On the surface of a wound, both can also be isolated infection with long-acting broad-spectrum antibacterial, while building certain humidity environment for wound face,
To advantageously promote the division growth of notch cell, accelerate the growth of granulation, and then promote the healing of notch.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Within mind and principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (6)
1. a kind of functionality Wound-protection liquid body dressing, which is characterized in that by mass percentage, the solid containing 0.26-0.5% is former
Material, surplus is water, wherein the solid material includes following component: chitosan quaternary ammonium salt 23-65%, organosilicon quaternary ammonium salt
18-50%, double-chain quaternary ammonium salt 15-46%, Sodium Hyaluronate 1-6%, vitamin B12 0.6-2%, solid material each group divide it
Be 100%；
The functional Wound-protection liquid body dressing the preparation method comprises the following steps:
1) organosilicon quaternary ammonium salt is dissolved in water and is configured to the organosilicone quaternary ammonium salting liquid that mass concentration is 6~10%；By hyalomitome
After sour sodium and vitamin B12 are dissolved in water, adjusting pH is 5.0, and temperature is 35 DEG C；
2) water is added in agitator tank, mixing speed is 15~25 revs/min, and chitosan quaternary ammonium salt and double-strand quaternary ammonium is first added
Salt makes it completely dissolved, and the time 1~2 hour；
3) 6~10% organosilicone quaternary ammonium salting liquids of step 1) preparation are added while stirring again, are sufficiently stirred 2~3 hours；
4) finally add step 1) preparation Sodium Hyaluronate and vitamin B12 aqueous solution, mixing speed be 30~50 turns/
Minute, it is sufficiently stirred, the time 3~4 hours；
5) filtering of mixed solution obtained by step 4) is placed in container, overnight to eliminate bubble, next day measurement solid content exists
0.26~0.5%, semi-finished product of the pH value 4.8~7.2, after Sterility testing is qualified, bottle body packing, as finished product.
2. functionality Wound-protection liquid body dressing according to claim 1, which is characterized in that by mass percentage, contain 0.3%
Solid material, surplus is water, wherein the solid material includes following component: chitosan quaternary ammonium salt 27.4%, organosilicon
Quaternary ammonium salt 20%, double-chain quaternary ammonium salt 46%, Sodium Hyaluronate 6%, vitamin B12 0.6%, the sum of solid material each component are
100%.
3. functionality Wound-protection liquid body dressing according to claim 1, which is characterized in that the molecular weight of the Sodium Hyaluronate
For 50~2000kDa.
4. functionality Wound-protection liquid body dressing according to claim 3, which is characterized in that the molecular weight of the Sodium Hyaluronate
For 100kDa.
5. functionality Wound-protection liquid body dressing according to claim 1, which is characterized in that in step 1), organosilicon quaternary ammonium salt
The mass concentration of solution is 6%.
6. functionality Wound-protection liquid body dressing according to claim 1, which is characterized in that in step 5), pH value 6.8.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810992151.8A CN109010907B (en) | 2018-08-29 | 2018-08-29 | A kind of functionality Wound-protection liquid body dressing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810992151.8A CN109010907B (en) | 2018-08-29 | 2018-08-29 | A kind of functionality Wound-protection liquid body dressing and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109010907A CN109010907A (en) | 2018-12-18 |
| CN109010907B true CN109010907B (en) | 2019-10-29 |
Family
ID=64625985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810992151.8A Active CN109010907B (en) | 2018-08-29 | 2018-08-29 | A kind of functionality Wound-protection liquid body dressing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010907B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110559475A (en) * | 2019-09-19 | 2019-12-13 | 广州博民生物科技有限公司 | Compound liquid dressing and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100471528C (en) * | 2006-06-09 | 2009-03-25 | 山东省医疗器械研究所 | Liquid wound-dressing with functions of promoting heal of wound and bacterial-resisting |
| CN103301501B (en) * | 2013-06-18 | 2015-05-06 | 王珍 | Medical liquid dressing and preparation method thereof |
| CN103495199B (en) * | 2013-10-08 | 2015-10-21 | 山东赛克赛斯药业科技有限公司 | A kind of laser for the treatment of is burnt and the hydrogel wound dressing and preparation method thereof of burn and scald |
| CN107854722B (en) * | 2017-10-31 | 2020-11-10 | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | Two-component liquid dressing for wound repair and using method thereof |
-
2018
- 2018-08-29 CN CN201810992151.8A patent/CN109010907B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN109010907A (en) | 2018-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3672655B1 (en) | Biomaterial and methods of making and using said biomaterial | |
| CN106822988B (en) | Alginate fiber functional dressing and application thereof, and alginate fiber functional dressing patch | |
| CN107617121B (en) | Biological induction active dressing for skin wound surface and preparation method and application thereof | |
| CN109432481A (en) | A kind of polyurethane dressing of hemostatic and antibacterial and preparation method thereof | |
| CN105012993A (en) | Medical and antibacterial cationic biogel dressing and preparation method thereof | |
| CN106377791A (en) | Bamboo alginate functional dressing and preparation method thereof | |
| CN111068103B (en) | Long-acting antibacterial gel dressing for operation wound and preparation method thereof | |
| CN110859989B (en) | Liquid band-aid and preparation method thereof | |
| CN105168238A (en) | Hyaluronic temperature-sensitive gel and preparation method and application thereof | |
| CN106947095A (en) | A kind of preparation method for wound healing antibacterial type hydrogel | |
| CN1686158A (en) | Adhesive bandage containing hyaluronic acid biological composition | |
| US20050181025A1 (en) | Preparation for wound healing and prevention of bandage adhesion to the wound | |
| CN111166932B (en) | Liquid wound spray dressing and preparation method thereof | |
| CN104740141B (en) | A kind of antimicrobial spray and preparation method thereof | |
| CN109010907B (en) | A kind of functionality Wound-protection liquid body dressing and preparation method thereof | |
| CN109432483B (en) | Medical dressing for accelerating wound healing and preparation method and application thereof | |
| CN111991612A (en) | Preparation method of liquid dressing with analgesic and antibacterial functions | |
| EP3585422B1 (en) | Antiseptic composition comprising unithiol and dimethylsulfoxide, use of the composition and method of wound treatment with its use | |
| CN107595819B (en) | A kind of Nano diamond modified liquid adhesive bandage and preparation method thereof | |
| RU2284824C1 (en) | Surgical antiseptic glue "argacol" | |
| CN109200326A (en) | Dressing and bandage for wound healing | |
| CN108096276A (en) | A kind of debridement healing washing lotion and its application | |
| EP3656404A1 (en) | Film for topical use for treating skin lesions and method for producing and applying same | |
| CN111729127A (en) | Dressing for wound care and preparation method thereof | |
| CN110251716A (en) | A kind of wound care gel dressing and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20221021 Address after: 570100 South District, second floor, building 1, No. 10, Jianshe SANHENG Road, Jinpan, Longhua District, Haikou City, Hainan Province Patentee after: HAINAN YIHONG INDUSTRIAL DEVELOPMENT Co.,Ltd. Address before: 4 / F, building 01, No. 10, SANHENG Road, Jinpan Jianshe, Longhua District, Haikou City, Hainan Province 570100 Patentee before: HAINAN HONGYI MEDICAL INSTRUMENT Co.,Ltd. |