CN110559475A - Compound liquid dressing and preparation method thereof - Google Patents
Compound liquid dressing and preparation method thereof Download PDFInfo
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- CN110559475A CN110559475A CN201910887675.5A CN201910887675A CN110559475A CN 110559475 A CN110559475 A CN 110559475A CN 201910887675 A CN201910887675 A CN 201910887675A CN 110559475 A CN110559475 A CN 110559475A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/009—Materials resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
- A61L2300/208—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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Abstract
the invention discloses a compound liquid dressing and a preparation method thereof, wherein the compound liquid dressing comprises the following components in parts by mass: 0.2-2 parts of a film forming agent; 0.25-2 parts of an antibacterial agent; 0.05-2.5 parts of a humectant; wherein the total mass part of the compound liquid dressing is 100 parts, the balance is deionized water, and the deionized water is not lower than the purified water grade of Chinese pharmacopoeia; the preparation method comprises the following steps: s1, sterilizing; s2, adding 1/2 of deionized water, stirring and adding a film-forming agent at a rotating speed of 200r/min, then flushing the reaction container with 1/5 of the rest deionized water, adjusting the rotating speed to 40-80r/min, and continuously stirring for 3-5 h; s3, adding the antibacterial agent, the humectant and the residual deionized water, and continuously stirring for 2-3 h; s4, placing the solution prepared in the S3 in an elevated tank, standing for 24-36h to eliminate bubbles, and filling to obtain the compound liquid dressing, wherein the compound liquid dressing has the advantages that the wound is not easy to be injured again, and the antibacterial ability and the healing ability of the wound are improved.
Description
Technical Field
the invention relates to the technical field of medical surgery medicines, in particular to a compound liquid dressing and a preparation method thereof.
Background
Skin trauma refers to skin damage caused by mechanically or chemically traumatizing factors. Tissue protection and repair after skin trauma is one of the oldest subjects in medicine, and the traditional method mainly depends on dressings such as gauze, cotton pads, application and the like to cover wounds, and has the advantages of low cost and strong physical protection effect.
However, the skin wound repair by the conventional method is easy to cause granulation tissues to grow into meshes of the gauze to cause adhesion and scab, so that the wound is easily damaged again when the dressing such as the gauze, the cotton pad or the patch is removed, and patients are easy to suffer intolerable pain, so that the improvement space is still left.
Disclosure of Invention
Aiming at the defects in the prior art, the first purpose of the invention is to provide a compound liquid dressing which has the advantage of being not easy to injure the wound again.
The second purpose of the invention is to provide a preparation method of the compound liquid dressing, which has the advantage that the prepared compound liquid dressing has the advantage of being not easy to injure the wound again.
In order to achieve the first object, the invention provides the following technical scheme:
A compound liquid dressing comprises the following components in parts by mass:
0.2-2 parts of a film forming agent;
0.25-2 parts of an antibacterial agent;
0.05-2.5 parts of a humectant;
The compound liquid dressing comprises 100 parts of deionized water in parts by weight, and the balance of the deionized water, wherein the deionized water is not lower than the purified water grade of Chinese pharmacopoeia.
Adopt above-mentioned technical scheme, make compound liquid dressing through adopting the film-forming agent of certain quantity proportion, antiseptic and humectant and deionized water complex formulation, make compound liquid dressing only need wash compound liquid dressing directly to skin wound face when using, spraying wet compress or cover, high durability and convenient use, and simultaneously, cover skin wound face through the spraying, make compound liquid dressing form the protection film on skin wound surface, be favorable to carrying out isolation protection to skin wound, thereby make the granulation tissue that grows out be difficult to take place the adhesion with the dressing, and then make the wound be difficult to damage once more, be favorable to alleviateing patient's painful sense.
In the invention, the film forming agent can be one or more of chitosan derivatives, glucosamine derivatives, protein film forming agents, acrylic resin film forming agents, butadiene resin film forming agents, polyurethane film forming agents, nitrocellulose film forming agents, propylene resin modified casein film forming agents, acrylic resin polyurethane copolymer resins, polyurethane modified nitrocellulose film forming agents and the like, wherein the chitosan derivatives comprise one or more of carboxymethyl chitosan, carboxymethyl chitosan sodium salt, hydroxyethyl chitosan, hydroxypropyl chitosan, chitosan quaternary ammonium salt and chitosan hydrochloride, and the glucosamine derivatives comprise one or more of glucosamine hydrochloride, glucosamine sulfate, glucosamine hydrochloride and glucosamine sulfate.
In the present invention, the antibacterial agent may be one or more of vanillin type compound antibacterial agent, ethyl vanillin type compound antibacterial agent, anilide type antibacterial agent, imidazole type antibacterial agent, thiazole type antibacterial agent, isothiazolone derivative antibacterial agent, quaternary ammonium salt type antibacterial agent, biguanidine type antibacterial agent, phenol type antibacterial agent, chitin, mustard, castor oil, horseradish, etc.
in the present invention, the humectant may be one or more of glycerin, butylene glycol, polyethylene glycol, propylene glycol, hexylene glycol, xylitol, polypropylene glycol, sorbitol, amino acids, sodium lactate, urea, vegetable protein, soybean protein, animal protein, hydrolyzed protein, collagen, hyaluronic acid, glycoprotein, chondroitin sulfate, ceramide, and the like.
the skin wound is repaired by directly spraying or washing the skin wound surface, so that the positions of certain wound parts such as oral cavity, anus, joints and the like which are inconvenient to use the traditional dressing are more convenient to repair, and the application range of the compound liquid dressing is favorably expanded.
Meanwhile, the compound liquid dressing is adopted to repair the skin wound in a mode of flushing or spraying, so that the antibacterial capacity and the healing capacity of the skin wound are improved, and the repair speed of the skin wound is higher.
The invention is further configured to: the film forming agent is one or more of glucosamine derivatives.
by adopting the technical scheme, one or more glucosamine derivatives are used as the film forming agent, so that the time for forming the protective film on the wound by the compound liquid dressing is favorably shortened, the antibacterial capability and the healing capability of the skin wound are favorably improved, and the repair speed of the skin wound is faster; meanwhile, the protective film formed by the compound liquid dressing can be automatically degraded, so that the grown granulation tissue is not easy to adhere to the dressing, and the dressing change of a patient is painless.
the invention is further configured to: the molecular weight of the glucosamine derivative is not less than 80 kDa.
by adopting the technical scheme, the adhesiveness of the compound liquid dressing and the skin wound is favorably enhanced by controlling the molecular weight of the glucosamine derivative, so that the compound liquid dressing is more easily adhered to the skin wound to form a protective film, and the grown granulation tissue is more difficult to adhere to the dressing, thereby alleviating the pain of a patient during dressing change, and simultaneously, the compound liquid dressing is also favorable for better improving the antibacterial capability and the healing capability of the skin wound, so that the repair speed of the skin wound is faster.
The invention is further configured to: the antibacterial agent is one or more of quaternary ammonium salt antibacterial materials.
by adopting the technical scheme, one or more of the quaternary ammonium salt antibacterial materials are used as the antibacterial agent, the quaternary ammonium salt antibacterial materials are cationic antibacterial agents, and the antibacterial effect is achieved through physical adsorption, so that the use of antibiotics is reduced, drug resistance is not generated, meanwhile, the quaternary ammonium salt antibacterial materials are more easily attached to the protective film to achieve a long-time antibacterial effect, the skin wound is enabled to be less prone to infection, and the repair speed of the skin wound is accelerated.
the invention is further configured to: the humectant comprises one or more of glycerol, 1, 2-hexanediol, 1, 3-butanediol and sodium hyaluronate.
By adopting the technical scheme, one or more of glycerol, 1, 2-hexanediol, 1, 3-butanediol and sodium hyaluronate are used as the humectant, so that the moisturizing effect of the compound liquid dressing is improved, a moist environment is provided for skin wounds better, and the healing speed of the wounds is accelerated.
The invention is further configured to: the compound liquid dressing comprises the following components in parts by mass:
1 part of glucosamine hydrochloride; 0.25 part of organosilicon quaternary ammonium salt; 2 parts of 1, 3-butanediol; 0.5 part of 1, 2-hexanediol; and 96.25 parts of deionized water.
By adopting the technical scheme, the glucose hydrochloride is used as a film forming agent, the organosilicon quaternary ammonium salt is used as an antibacterial agent, the 1, 3-butanediol and the 1, 2-hexanediol are used as humectants, and the components are cooperatively matched with each other according to a certain dosage ratio, so that the compound liquid dressing is favorable for better playing a role, has a better antibacterial effect and a better effect of promoting wound healing, and is favorable for accelerating the repair speed of skin wounds.
in order to achieve the second object, the invention provides the following technical scheme:
A preparation method of the compound liquid dressing comprises the following steps:
S1, sterilizing the reaction container and the instruments to be used;
S2, adding 1/2 amount of deionized water into the reaction container, stirring at a rotating speed of 200r/min, adding the film forming agent while stirring, controlling the film forming agent not to coagulate into a dough, after the addition is finished, flushing the reaction container with 1/5 amount of deionized water of the rest amount of deionized water, adjusting the rotating speed to 40-80r/min, and continuously stirring for 3-5 hours;
S3, when the clear solution without particles is prepared in the S2, adding the antibacterial agent and the humectant, washing the reaction container with the residual deionized water, controlling the stirring speed at 40-80r/min and the stirring temperature at 25-50 ℃, and continuously stirring for 2-3 h;
S4, placing the solution prepared in the S3 in an elevated tank, standing for 24-36h to eliminate bubbles, and filling to obtain the compound liquid dressing.
By adopting the technical scheme, the stirring speed and the temperature of the compound liquid dressing in the preparation process are controlled, so that the production efficiency of the compound liquid dressing is improved, meanwhile, the degradation of macromolecular polymers is reduced as much as possible, the film forming performance of the compound liquid dressing is better, the antibacterial effect of the compound liquid dressing is improved, the effect of promoting wound healing is improved, and the repair speed of skin wounds is higher.
The invention is further configured to: the operations of step S1, step S2 and step S3 are all performed in a clean environment of not less than 10 ten thousand levels.
by adopting the technical scheme, the preparation operation of the compound liquid dressing is carried out in a clean environment which is not lower than 10 ten thousand levels, so that the compound liquid dressing is not easy to be polluted, the risk of skin wound infection is favorably reduced, the antibacterial effect of the compound liquid dressing is favorably improved, the effect of wound healing is favorably promoted, and the repair speed of the skin wound is faster.
The invention is further configured to: in step S2, the stirring temperature was controlled to 40 ℃.
By adopting the technical scheme, the stirring temperature is controlled to be 40 ℃, so that the degradation of macromolecular polymers is reduced as much as possible, the film-forming performance of the compound liquid dressing is better, the antibacterial effect of the compound liquid dressing is improved, the effect of promoting wound healing is promoted, and the repair speed of skin wounds is faster.
The invention is further configured to: in the step S4, the standing time is 24 h.
By adopting the technical scheme, the standing time of the compound liquid dressing is controlled, so that the antibacterial effect of the compound liquid dressing and the effect of promoting wound healing are improved, and the repair speed of skin wounds is higher.
in conclusion, the invention has the following beneficial effects:
1. By adopting the macromolecular glucosamine derivative as the film forming agent, the compound liquid dressing is favorable for forming a protective film on the surface of the skin wound, so that the compound liquid dressing can play a role of isolation and protection within a certain time, and the protective film is favorable for self-degradation, so that the grown granulation tissue is not easy to adhere to the dressing, and the dressing change of a patient is free from pain;
2. By adopting the quaternary ammonium salt antibacterial agent as the antibacterial agent and the quaternary ammonium salt antibacterial agent as the cationic antibacterial agent, the antibacterial effect is achieved through the physical adsorption effect, the use of antibiotics can be reduced, the drug resistance can not be generated, the antibacterial effect can be achieved for a long time by attaching the antibacterial agent on the protective film, and the risk of wound infection is effectively reduced;
3. the humectant is beneficial to providing a moist environment for the wound and accelerating the healing speed of the wound;
4. The stirring speed and the temperature of the compound liquid dressing in the preparation process are controlled, so that the production efficiency of the compound liquid dressing is improved, the degradation of macromolecular polymers is reduced as far as possible, the film-forming performance of the compound liquid dressing is better, the antibacterial effect of the compound liquid dressing is improved, the effect of promoting wound healing is facilitated, and the repair speed of skin wounds is higher.
Drawings
fig. 1 is a process flow chart of the preparation method of the compound liquid dressing of the invention.
Detailed Description
The present invention will be described in further detail with reference to the accompanying drawings and examples.
In the following examples, chitosan hydrochloride of model FT2565 from Shaanxi Runfeng biotechnology Limited is used.
in the following examples, chlorhexidine acetate from the Hubei Federation pharmaceutical Co., Ltd was used.
in the following examples, sorbitol was used as a commercial product No. 001 of Simarone Biotech Ltd.
In the following examples, glucosamine hydrochloride obtained from Gji dry Biotech, Inc. of Henan province was used.
In the following examples, Quaternary ammonium silicone salt from Wuhanxin Jiali Biotech GmbH was used.
In the following examples, 1, 3-butanediol obtained from Shanghai eosin industries, Ltd is used as 1, 3-butanediol.
In the following examples, 1, 2-hexanediol, available from Foshan New aviation Biotechnology Ltd under the trade name 0001, was used as 1, 2-hexanediol.
In the following examples, castor oil was produced from commercial product of Cinan Rach, Inc. under the reference number 2019.
In the following examples, glycerin obtained from Jun Chemicals, Inc. of Jinan Kai is used.
Example 1
a compound liquid dressing comprises the following components:
0.2kg of chitosan hydrochloride; 0.25kg of chlorhexidine acetate; 0.05kg of sorbitol; 99.5kg of deionized water.
the preparation method of the compound liquid dressing comprises the following steps:
S1, firstly, cleaning and disinfecting the stirring tank and the appliances needing to be used;
S2, adding 49.75kg of deionized water into the stirring tank, starting stirring, stirring at the rotating speed of 200r/min, slowly adding 0.2kg of chitosan hydrochloride while stirring, enabling the chitosan hydrochloride not to coagulate into a dough, after the addition is finished, washing the stirring tank by using 9.95kg of deionized water of the rest deionized water, adjusting the rotating speed to 40r/min, and continuously stirring for 5 hours;
S3, when a clear solution without particles is prepared in the S2, adding 0.25kg of chlorhexidine acetate and 0.05kg of sorbitol, washing the stirring tank by using 39.8kg of residual deionized water, controlling the stirring speed to be 40r/min, controlling the stirring temperature to be 25 ℃, and continuously stirring for 3 hours;
S4, placing the solution prepared in the S3 in an elevated tank, standing for 24 hours to eliminate bubbles, and filling to obtain the compound liquid dressing.
Example 2
A compound liquid dressing comprises the following components:
1.1kg of chitosan hydrochloride; chlorhexidine acetate 1.13 kg; 1.3kg of sorbitol; 96.47kg of deionized water.
the preparation method of the compound liquid dressing comprises the following steps:
S1, firstly, cleaning and disinfecting the stirring tank and the appliances needing to be used;
S2, adding 48.235kg of deionized water into a stirring tank, starting stirring, stirring at the rotating speed of 200r/min, slowly adding 1.1kg of chitosan hydrochloride while stirring, enabling the chitosan hydrochloride not to coagulate into a dough, flushing the stirring tank with 9.647kg of deionized water of the rest deionized water after the addition is finished, adjusting the rotating speed to 40r/min, and continuously stirring for 5 hours;
s3, when a clear solution without particles is prepared in the S2, adding 1.13kg of chlorhexidine acetate and 1.3kg of sorbitol, flushing the stirring tank by 38.588kg of residual deionized water, controlling the stirring speed to be 40r/min and the stirring temperature to be 25 ℃, and continuously stirring for 3 hours;
s4, placing the solution prepared in the S3 in an elevated tank, standing for 24 hours to eliminate bubbles, and filling to obtain the compound liquid dressing.
Example 3
A compound liquid dressing comprises the following components:
2kg of chitosan hydrochloride; 2kg of chlorhexidine acetate; 2.5kg of sorbitol; 93.5kg of deionized water.
The preparation method of the compound liquid dressing comprises the following steps:
S1, firstly, cleaning and disinfecting the stirring tank and the appliances needing to be used;
s2, adding 46.75kg of deionized water into the stirring tank, starting stirring, stirring at a rotating speed of 200r/min, slowly adding 2kg of chitosan hydrochloride while stirring, enabling the chitosan hydrochloride not to coagulate into a dough, after the addition is finished, washing the stirring tank with 9.35kg of deionized water of the rest deionized water, adjusting the rotating speed to 40r/min, and continuously stirring for 5 hours;
S3, when a clear solution without particles is prepared in the S2, adding 2kg of chlorhexidine acetate and 2.5kg of sorbitol, washing the stirring tank by 37.4kg of residual deionized water, controlling the stirring speed at 40r/min and the stirring temperature at 25 ℃, and continuously stirring for 3 hours;
S4, placing the solution prepared in the S3 in an elevated tank, standing for 24 hours to eliminate bubbles, and filling to obtain the compound liquid dressing.
example 4
a compound liquid dressing comprises the following components:
1kg of chitosan hydrochloride; 0.25kg of chlorhexidine acetate; 2.5kg of sorbitol; 96.25kg of deionized water.
The preparation method of the compound liquid dressing comprises the following steps:
S1, firstly, cleaning and disinfecting the stirring tank and the appliances needing to be used;
S2, adding 48.125kg of deionized water into a stirring tank, starting stirring, stirring at the rotating speed of 200r/min, slowly adding 1kg of chitosan hydrochloride while stirring, enabling the chitosan hydrochloride not to coagulate into a dough, after the addition is finished, washing the stirring tank by using 9.625kg of deionized water of the rest deionized water, adjusting the rotating speed to 40r/min, and continuously stirring for 5 hours;
s3, when a clear solution without particles is prepared in the S2, adding 0.25kg of chlorhexidine acetate and 2.5kg of sorbitol, washing the stirring tank by using 38.5kg of residual deionized water, controlling the stirring speed to be 40r/min, controlling the stirring temperature to be 25 ℃, and continuously stirring for 3 hours;
S4, placing the solution prepared in the S3 in an elevated tank, standing for 24 hours to eliminate bubbles, and filling to obtain the compound liquid dressing.
Example 5
the difference from example 4 is that:
in step S2, deionized water is added to flush the stirring tank, the rotation speed is adjusted to 60r/min, and stirring is continued for 4 h.
In step S3, deionized water is added to flush the stirring tank, the stirring speed is controlled at 60r/min, the stirring temperature is controlled at 37.5 ℃, and the stirring is continued for 2.5 h.
In step S4, the standing time of the solution in the head tank is controlled to be 30 h.
Example 6
The difference from example 4 is that:
In step S2, deionized water is added to flush the stirring tank, the rotation speed is adjusted to 80r/min, and stirring is continued for 3 h.
in step S3, deionized water is added to flush the stirring tank, the stirring speed is controlled at 80r/min, the stirring temperature is controlled at 50 ℃, and the stirring is continued for 2 h.
In step S4, the standing time of the solution in the head tank is controlled to be 36 h.
Example 7
The difference from example 4 is that:
in step S2, deionized water is added to flush the stirring tank, the rotation speed is adjusted to 50r/min, and stirring is continued for 3 h.
in step S3, deionized water is added to flush the stirring tank, the stirring speed is controlled at 50r/min, the stirring temperature is controlled at 40 ℃, and the stirring is continued for 2 h.
In step S4, the standing time of the solution in the head tank is controlled to be 24 h.
example 8
A compound liquid dressing comprises the following components:
1kg of glucosamine hydrochloride; 0.25kg of organosilicon quaternary ammonium salt; 2kg of 1, 3-butanediol; 0.5kg of 1, 2-hexanediol; 96.25kg of deionized water.
The preparation method of the compound liquid dressing comprises the following steps:
S1, firstly, cleaning and disinfecting the stirring tank and the appliances needing to be used;
s2, adding 48.125kg of deionized water into a stirring tank, starting stirring, stirring at a rotating speed of 200r/min, slowly adding 1kg of glucosamine hydrochloride while stirring, enabling the glucosamine hydrochloride not to be coagulated into a dough, flushing the stirring tank with 9.625kg of the rest deionized water after the addition is finished, adjusting the rotating speed to 50r/min, and continuously stirring for 3 hours;
S3, when a clear solution without particles is prepared in the S2, adding 0.25kg of organosilicon quaternary ammonium salt, 2kg of 1, 3-butanediol and 0.5kg of 1, 2-hexanediol, washing a stirring tank by using 38.5kg of the rest deionized water, controlling the stirring speed to be 50r/min, controlling the stirring temperature to be 40 ℃, and continuously stirring for 2 hours;
S4, placing the solution prepared in the S3 in an elevated tank, standing for 24 hours to eliminate bubbles, and filling to obtain the compound liquid dressing.
example 9
The difference from example 8 is that: the glucosamine hydrochloride in the compound liquid dressing is replaced by chitosan hydrochloride.
Example 10
the difference from example 8 is that: the component organosilicon quaternary ammonium salt in the compound liquid dressing is replaced by castor oil.
Example 11
The difference from example 8 is that: the components of 1, 3-butanediol and 1, 2-hexanediol in the compound liquid dressing are replaced by glycerol.
example 12
The difference from example 8 is that: the dosage of the glucose hydrochloride in the compound liquid dressing is replaced by 1.5kg, and the dosage of the deionized water is correspondingly replaced by 95.75 kg.
Example 13
The difference from example 8 is that: the usage amount of the component organosilicon quaternary ammonium salt in the compound liquid dressing is replaced by 0.5kg, and the usage amount of the deionized water is correspondingly replaced by 96 kg.
Example 14
The difference from example 8 is that: the dosage of the component 1, 3-butanediol in the compound liquid dressing is replaced by 2.3kg, the dosage of the component 1, 2-hexanediol is replaced by 0.7kg, and the dosage of deionized water is correspondingly replaced by 95.75 kg.
Experiment 1
0.1mL of bacterial liquid (strain concentration 10)6cfu/mL) was uniformly coated on an LB agar plate, and the compound liquid dressing prepared in the above examples and comparative examples was sprayed on the surface of the LB agar plate to cover the bacterial liquid, and the applied and covered LB agar plate was used as a control group, and then the LB agar plate was cultured in a 37 ℃ incubator for 16 hours, and each of the examples, comparative examples and control group was subjected to 4 plate experiments, and the bacteriostatic ratio (%) of the cultured strain on the LB agar plate was measured.
Experiment 2
The compound liquid dressing prepared by the above examples and comparative examples is used for animal skin wound repair experiments, and the details are as follows:
the experimental animals adopt wistar rats, each group is 10, the weight is 250g-300g, the male and female parts are half, the backs of the rats are depilated by 8% sodium sulfide solution, pentobarbital sodium is administered to the abdominal cavity after 24 hours, circular full-skin symmetrical incisions with the diameter of about 2.0cm are detected at positions 2.0cm away from the two sides of the spinal column by surgical scissors after anesthesia is successful, then the rats are disinfected by 70% alcohol solution, and finally the compound liquid dressings prepared by the above embodiments and comparative examples are respectively sprayed on the wounds of the rats of different groups and are bound by using a patch, in addition, the wounds are directly bound by using the patch as a control group, and the healing condition of the wounds and the condition of granulation tissue adhesion patch are observed and recorded.
The results of the above experiments are shown in Table 1.
TABLE 1
according to the comparison of the data of the examples 1 to 4 in the table 1, the compound liquid dressing is favorable for better forming a protective film at the skin wound to isolate and protect the wound by controlling the dosage of each component in the compound liquid dressing, so that the antibacterial capability of the skin wound is favorably improved, and the repair speed of the skin wound is faster.
According to the data comparison of the embodiment 4-7 in the table 1, the degradation of macromolecular polymers in the compound liquid dressing is favorably reduced by controlling the stirring speed and the temperature in the preparation process of the compound liquid dressing, so that the film-forming property of the compound liquid dressing is better, the compound liquid dressing is favorably prevented from being isolated and protected from wounds by better forming a protective film, the antibacterial effect of the compound liquid dressing and the effect of promoting the healing of the wounds are better, and the healing speed of the wounds is favorably accelerated.
According to the comparison of the data of the example 7 and the example 8 in the table 1, the glucosamine derivative is used as the film forming agent, the quaternary ammonium salt antibacterial material is used as the antibacterial agent, and the 1, 3-butanediol and the 1, 2-hexanediol are matched to form the humectant, so that the components are better matched with each other in a synergistic manner to exert a better effect, the antibacterial capability of the compound liquid dressing is enhanced, the wound healing capability is promoted, and the wound healing speed is higher.
according to the data comparison of the examples 8 to 11 in the table 1, the compound liquid dressing can better improve the antibacterial ability and the wound healing promoting ability of the compound liquid dressing only when the glucose hydrochloride, the organosilicon quaternary ammonium salt, the 1, 3-butanediol and the 1, 2-hexanediol are synergistically matched with each other, so that the wound healing speed is higher, and the compound liquid dressing is easy to influence the effect due to the lack of any component.
According to the comparison of the data of example 8 and examples 12-14 in table 1, the antibacterial ability and the wound healing promoting ability of the compound liquid dressing can be better improved only when the glucose hydrochloride, the organosilicon quaternary ammonium salt, the 1, 3-butanediol and the 1, 2-hexanediol are matched by specific dosage, so that the wound healing speed is higher, and the effect of the compound liquid dressing is easily influenced by changing the dosage of any component.
According to the comparison of the data of the examples 1-14 in the table 1 and the data of the control group, the compound liquid dressing is adopted to spray the skin wound, so that the compound liquid dressing is beneficial to forming a protective film at the skin wound to isolate granulation tissues and apply the granulation tissues, the granulation tissues are less prone to being adhered to the application in the recovery process, the pain of a patient during dressing change is relieved, meanwhile, the antibacterial capacity and the healing capacity of the skin wound are enhanced, and the healing speed of the skin wound is higher. In addition, the total content of the film-forming agent, the antibacterial agent and the humectant in the compound liquid dressing only needs to reach 0.5-6.5%, so that the compound liquid dressing has good antibacterial performance and the effect of promoting wound healing, the cost is saved, and meanwhile, the influence of chemical substances on the environment is reduced.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (10)
1. a compound liquid dressing is characterized in that: the paint comprises the following components in parts by mass:
0.2-2 parts of a film forming agent;
0.25-2 parts of an antibacterial agent;
0.05-2.5 parts of a humectant;
the compound liquid dressing comprises 100 parts of deionized water in parts by weight, and the balance of the deionized water, wherein the deionized water is not lower than the purified water grade of Chinese pharmacopoeia.
2. the compound liquid dressing according to claim 1, wherein: the film forming agent is one or more of glucosamine derivatives.
3. the compound liquid dressing according to claim 1, wherein: the molecular weight of the glucosamine derivative is not less than 80 kDa.
4. the compound liquid dressing according to claim 1, wherein: the antibacterial agent is one or more of quaternary ammonium salt antibacterial materials.
5. The compound liquid dressing according to claim 1, wherein: the humectant comprises one or more of glycerol, 1, 2-hexanediol, 1, 3-butanediol and sodium hyaluronate.
6. the compound liquid dressing according to any one of claims 1-5, wherein: the compound liquid dressing comprises the following components in parts by mass:
1 part of glucosamine hydrochloride; 0.25 part of organosilicon quaternary ammonium salt; 2 parts of 1, 3-butanediol; 0.5 part of 1, 2-hexanediol; and 96.25 parts of deionized water.
7. A method of preparing a compound liquid dressing as claimed in any one of claims 1 to 6, wherein: the method comprises the following steps:
s1, sterilizing the reaction container and the instruments to be used;
S2, adding 1/2 amount of deionized water into the reaction container, stirring at a rotating speed of 200r/min, adding the film forming agent while stirring, controlling the film forming agent not to coagulate into a dough, after the addition is finished, flushing the reaction container with 1/5 amount of deionized water of the rest amount of deionized water, adjusting the rotating speed to 40-80r/min, and continuously stirring for 3-5 hours;
s3, when the clear solution without particles is prepared in the S2, adding the antibacterial agent and the humectant, washing the reaction container with the residual deionized water, controlling the stirring speed at 40-80r/min and the stirring temperature at 25-50 ℃, and continuously stirring for 2-3 h;
s4, placing the solution prepared in the S3 in an elevated tank, standing for 24-36h to eliminate bubbles, and filling to obtain the compound liquid dressing.
8. The method for preparing the compound liquid dressing as claimed in claim 7, which is characterized in that: the operations of step S1, step S2 and step S3 are all performed in a clean environment of not less than 10 ten thousand levels.
9. The method for preparing the compound liquid dressing as claimed in claim 7, which is characterized in that: in step S2, the stirring temperature was controlled to 40 ℃.
10. the method for preparing the compound liquid dressing as claimed in claim 7, which is characterized in that: in the step S4, the standing time is 24 h.
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| CN111643723A (en) * | 2020-06-29 | 2020-09-11 | 华仁药业股份有限公司 | Liquid dressing containing icodextrin |
| CN111729124A (en) * | 2020-06-29 | 2020-10-02 | 华仁药业股份有限公司 | Wound dressing containing icodextrin |
| CN113577378A (en) * | 2021-08-28 | 2021-11-02 | 上海纤瑞生物技术有限公司 | Fibronectin liquid wound spray dressing and preparation method and application thereof |
| CN114225102A (en) * | 2021-12-28 | 2022-03-25 | 浙江蓝禾医疗用品有限公司 | Liquid dressing for wound protection and preparation method thereof |
| CN114225100A (en) * | 2021-12-22 | 2022-03-25 | 浙江清荣生物科技发展有限公司 | Porphyridium-based liquid dressing and preparation method thereof |
| WO2022133629A1 (en) * | 2020-12-21 | 2022-06-30 | 江苏奇力康皮肤药业有限公司 | Spray type liquid bandage and preparation method therefor |
| CN116019965A (en) * | 2023-03-27 | 2023-04-28 | 江苏亨瑞生物医药科技有限公司 | Collagen film dressing and preparation method thereof |
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| CN113577378A (en) * | 2021-08-28 | 2021-11-02 | 上海纤瑞生物技术有限公司 | Fibronectin liquid wound spray dressing and preparation method and application thereof |
| CN114225100A (en) * | 2021-12-22 | 2022-03-25 | 浙江清荣生物科技发展有限公司 | Porphyridium-based liquid dressing and preparation method thereof |
| CN114225102A (en) * | 2021-12-28 | 2022-03-25 | 浙江蓝禾医疗用品有限公司 | Liquid dressing for wound protection and preparation method thereof |
| CN116173291A (en) * | 2023-03-08 | 2023-05-30 | 重庆医科大学附属第二医院 | Chitosan recombinant humanized collagen gel and preparation method and application thereof |
| CN116019965A (en) * | 2023-03-27 | 2023-04-28 | 江苏亨瑞生物医药科技有限公司 | Collagen film dressing and preparation method thereof |
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