CN114225102A - Liquid dressing for wound protection and preparation method thereof - Google Patents
Liquid dressing for wound protection and preparation method thereof Download PDFInfo
- Publication number
- CN114225102A CN114225102A CN202111621290.8A CN202111621290A CN114225102A CN 114225102 A CN114225102 A CN 114225102A CN 202111621290 A CN202111621290 A CN 202111621290A CN 114225102 A CN114225102 A CN 114225102A
- Authority
- CN
- China
- Prior art keywords
- wound protection
- liquid
- liquid dressing
- antibacterial agent
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 55
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 22
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 20
- 239000002904 solvent Substances 0.000 claims abstract description 20
- 229920001577 copolymer Polymers 0.000 claims abstract description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 33
- 238000003756 stirring Methods 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 9
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 9
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 6
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 claims description 6
- DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 claims description 6
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 claims description 6
- FLKPEMZONWLCSK-UHFFFAOYSA-N diethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(=O)OCC FLKPEMZONWLCSK-UHFFFAOYSA-N 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 6
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 claims description 6
- 239000004014 plasticizer Substances 0.000 claims description 6
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 6
- -1 polydimethylsiloxane Polymers 0.000 claims description 6
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 6
- 239000001069 triethyl citrate Substances 0.000 claims description 6
- VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 claims description 6
- 235000013769 triethyl citrate Nutrition 0.000 claims description 6
- 229920001661 Chitosan Polymers 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- UQEAIHBTYFGYIE-UHFFFAOYSA-N hexamethyldisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 claims description 5
- 229940073561 hexamethyldisiloxane Drugs 0.000 claims description 5
- 239000003906 humectant Substances 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 229940057995 liquid paraffin Drugs 0.000 claims description 4
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical class O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 claims description 3
- ZILVNHNSYBNLSZ-UHFFFAOYSA-N 2-(diaminomethylideneamino)guanidine Chemical compound NC(N)=NNC(N)=N ZILVNHNSYBNLSZ-UHFFFAOYSA-N 0.000 claims description 3
- 229920002101 Chitin Polymers 0.000 claims description 3
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 claims description 3
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 claims description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 3
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical compound C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 3
- 150000003931 anilides Chemical class 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- FBSAITBEAPNWJG-UHFFFAOYSA-N dimethyl phthalate Natural products CC(=O)OC1=CC=CC=C1OC(C)=O FBSAITBEAPNWJG-UHFFFAOYSA-N 0.000 claims description 3
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 claims description 3
- 229960001826 dimethylphthalate Drugs 0.000 claims description 3
- 229940073505 ethyl vanillin Drugs 0.000 claims description 3
- 238000011049 filling Methods 0.000 claims description 3
- 229960005150 glycerol Drugs 0.000 claims description 3
- 239000001087 glyceryl triacetate Substances 0.000 claims description 3
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 3
- 238000010438 heat treatment Methods 0.000 claims description 3
- PQPVPZTVJLXQAS-UHFFFAOYSA-N hydroxy-methyl-phenylsilicon Chemical compound C[Si](O)C1=CC=CC=C1 PQPVPZTVJLXQAS-UHFFFAOYSA-N 0.000 claims description 3
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims description 3
- 229940075495 isopropyl palmitate Drugs 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims description 3
- 229960002622 triacetin Drugs 0.000 claims description 3
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 claims description 3
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 claims description 3
- 235000012141 vanillin Nutrition 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010040880 Skin irritation Diseases 0.000 abstract description 3
- 230000036556 skin irritation Effects 0.000 abstract description 3
- 231100000475 skin irritation Toxicity 0.000 abstract description 3
- 206010052428 Wound Diseases 0.000 description 22
- 208000027418 Wounds and injury Diseases 0.000 description 22
- 241000700159 Rattus Species 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 5
- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical group CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 5
- 230000003902 lesion Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 208000035874 Excoriation Diseases 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- 230000008034 disappearance Effects 0.000 description 2
- 229940035535 iodophors Drugs 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 240000007311 Commiphora myrrha Species 0.000 description 1
- 235000006965 Commiphora myrrha Nutrition 0.000 description 1
- 241001043298 Croton draco Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 1
- 244000131316 Panax pseudoginseng Species 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000009136 dragon's blood Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a liquid dressing for wound protection, and belongs to the technical field of liquid dressings. The liquid dressing for wound protection comprises the following components in percentage by mass: 3-18% of film forming agent, 82-97% of volatile solvent and 0-1% of auxiliary agent. The film forming agent is acrylate copolymer. The invention also discloses a preparation method of the liquid dressing for wound protection. The liquid dressing for wound protection, which is adopted by the invention, can solve the problems of high price and skin irritation of the existing liquid dressing, and has the advantages of good waterproofness and quick film forming.
Description
Technical Field
The invention relates to the technical field of liquid dressings, in particular to a liquid dressing for wound protection and a preparation method thereof.
Background
The skin is an important multifunctional organ of the human body and is also the organ with the largest area. The skin is a barrier for the human body to contact with the external environment, and plays a role of protecting the body, but is also very easy to be damaged. The wound types comprise burns, scalds, cuts, abrasions and the like, but because the skin has an important function, the skin abrasion caused by operation incisions and various traumas can be nursed as soon as possible, the problems of skin pollution, inflammation and the like are avoided, and the skin tissue and function are recovered.
The existing skin wound protection is mainly carried out by dressing, the dressing is wrapped on the wound, and the wound is prevented from being polluted by the outside. Traditional dressings such as gauze are often opaque, do not have a waterproof function, and do not have a better protective effect. The ideal wound repair environment is to have good breathability and barrier properties under conditions effective to keep the wound wet to some extent. The liquid dressing is a novel wound dressing, and the existing liquid dressing is added with important extracts of pseudo-ginseng, dragon's blood, myrrh and the like, so that the dressing has certain irritation to skin and higher price.
Disclosure of Invention
The invention aims to provide a liquid dressing for wound protection, which solves the problems of high price and skin irritation of the existing liquid dressing. Another object of the present invention is to provide a method for preparing a liquid dressing for wound protection.
In order to achieve the aim, the invention provides a liquid dressing for wound protection, which comprises the following components in percentage by mass: 3-18% of film forming agent, 82-97% of volatile solvent and 0-1% of auxiliary agent.
Preferably, the film-forming agent is an acrylate copolymer.
Preferably, the volatile solvent is one or more of ethanol, isopropanol, polydimethylsiloxane, polyethyl phenyl methyl siloxane, hexamethyl disiloxane, isooctane, acetone and diethyl ether.
Preferably, the auxiliary agent is one or a mixture of softening humectant, plasticizer and antibacterial agent.
Preferably, the softening and moisturizing agent is one or a mixture of glycerol, liquid paraffin and sodium hyaluronate.
Preferably, the plasticizer is one or a mixture of triethyl citrate, tributyl citrate, isopropyl palmitate, glyceryl triacetate, dimethyl phthalate, diethyl phthalate, dibutyl phthalate and dibutyl sebacate.
Preferably, the antibacterial agent is one or a mixture of more of water-soluble chitosan, vanillin antibacterial agents, ethyl vanillin antibacterial agents, anilide antibacterial agents, imidazole antibacterial agents, thiazole antibacterial agents, isothiazolone derivative antibacterial agents, quaternary ammonium salt antibacterial agents, biguanidine antibacterial agents, phenol antibacterial agents and chitin.
The preparation method of the liquid dressing for wound protection comprises the following steps:
s1, adding the volatile solvent into a liquid preparation tank, and stirring at the room temperature at the rotating speed of 500r/min for 5-20 min;
s2, heating the liquid preparation tank to 40-60 ℃, continuously stirring at the rotating speed of 500r/min, adding the film forming agent, and uniformly mixing;
s3, cooling to room temperature, and continuing stirring for 1-3h at the rotating speed of 800-;
s4, adding the auxiliary agent into the mixed liquid prepared in the step S3, stirring while adding the auxiliary agent, wherein the stirring speed during adding is 500r/min, and stirring for 60min at the rotating speed of 1000r/min after adding;
and S5, standing for 30min, and filling after bubbles completely disappear.
The liquid dressing for wound protection and the preparation method thereof have the advantages and positive effects that:
1. the raw materials in the liquid dressing are all conventional materials, so that the price is low, and the cost of the liquid dressing is favorably reduced.
2. The liquid dressing is not added with traditional Chinese medicine components, so that the irritation is small.
3. The liquid dressing has high film forming speed and better waterproof effect, and is favorable for promoting the healing of wounds.
4. The preparation method of the liquid dressing is simple and easy to operate, does not need complex equipment, has less equipment investment and easy control of the process, and the prepared liquid dressing has more stable performance.
Detailed Description
A liquid dressing for wound protection comprises the following components in percentage by mass: 3-18% of film forming agent, 82-97% of volatile solvent and 0-1% of auxiliary agent.
The film forming agent is acrylate copolymer.
The volatile solvent is one or more of ethanol, isopropanol, polydimethylsiloxane, polyethyl phenyl methyl siloxane, hexamethyl disiloxane, isooctane, acetone, and diethyl ether.
The auxiliary agent is one or a mixture of more of a softening humectant, a plasticizer and an antibacterial agent.
The softening humectant is one or more of glycerol, liquid paraffin and sodium hyaluronate.
The plasticizer is one or more of triethyl citrate, tributyl citrate, isopropyl palmitate, triacetin, dimethyl phthalate, diethyl phthalate, dibutyl phthalate and dibutyl sebacate.
The antibacterial agent is one or more of water-soluble chitosan, vanillin antibacterial agent, ethyl vanillin antibacterial agent, anilide antibacterial agent, imidazole antibacterial agent, thiazole antibacterial agent, isothiazolone derivative antibacterial agent, quaternary ammonium salt antibacterial agent, biguanidine antibacterial agent, phenol antibacterial agent and chitin.
The preparation method of the liquid dressing for wound protection comprises the following steps:
s1, adding the volatile solvent into a liquid preparation tank, and stirring at the room temperature at the rotating speed of 500r/min for 5-20 min;
s2, heating the liquid preparation tank to 40-60 ℃, continuously stirring at the rotating speed of 500r/min, adding the film forming agent, and uniformly mixing;
s3, cooling to room temperature, and continuing stirring for 1-3h at the rotating speed of 800-;
s4, adding the auxiliary agent into the mixed liquid prepared in the step S3, stirring while adding the auxiliary agent, wherein the stirring speed during adding is 500r/min, and stirring for 60min at the rotating speed of 1000r/min after adding;
and S5, standing for 30min, and filling after bubbles completely disappear.
The technical solution of the present invention is further illustrated by the following examples.
Example one
The liquid dressing for wound protection comprises the following components in percentage by mass: 3% of film forming agent and 97% of volatile solvent.
The film forming agent is triisopropyl silicon-based acrylate.
The volatile solvent is polydimethylsiloxane.
Example two
The liquid dressing for wound protection comprises the following components in percentage by mass: 6% of film forming agent and 94% of volatile solvent.
The film forming agent is triisopropyl silicon-based acrylate.
The volatile solvent is hexamethyldisiloxane.
EXAMPLE III
The liquid dressing for wound protection comprises the following components in percentage by mass: 12% of film forming agent, 87% of volatile solvent and 1% of auxiliary agent.
The film forming agent is triisopropyl silicon-based acrylate.
The volatile solvent is polydimethylsiloxane.
The auxiliary agent is sodium hyaluronate and triethyl citrate, and the mass fraction of the auxiliary agent is 50 percent respectively.
Example four
The liquid dressing for wound protection comprises the following components in percentage by mass: 18% of film forming agent, 81% of volatile solvent and 1% of auxiliary agent.
The film forming agent is triisopropyl silicon-based acrylate.
The volatile solvent is polydimethylsiloxane.
The auxiliary agent comprises 10% of sodium hyaluronate, 10% of liquid paraffin, 20% of triethyl citrate and 60% of water-soluble chitosan in percentage by mass.
EXAMPLE five
The liquid dressing for wound protection comprises the following components in percentage by mass: 6% of film forming agent, 93% of volatile solvent and 1% of auxiliary agent.
The film forming agent is triisopropyl silicon-based acrylate.
The volatile solvent is hexamethyldisiloxane.
The auxiliary agent comprises 20% of glycerol, 20% of triethyl citrate and 60% of water-soluble chitosan in percentage by mass.
Male SD rats 30 were divided into 6 groups numbered 1, 2, 3, 4, 5 and 6. Removing the hair on the back of the experimental rat, making a lesion with the length of about 2cm on the back, correspondingly smearing the liquid dressing prepared in the first to fifth embodiments on the lesion on the back of the rats in 1 to 5 groups respectively, and smearing once a day; group 6 rats served as a control group and were not treated for dorsal lesions. All 6 groups of rats were fed in a single cage. Rats were observed for healing of the dorsal lesions on days 3 and 7, respectively, and recorded, with the results shown in table 1.
TABLE 16 rat wound healing status
According to the experimental results in the table 1, the liquid dressing disclosed by the invention has good film forming property and has a good promotion effect on the healing of the wound surface.
30 volunteers were sampled and divided into 6 groups, numbered 1, 2, 3, 4, 5 and 6. Taking 2cm x2cm skin from the inner side of the forearm of the volunteer, smearing iodophor on the skin, drying, smearing the liquid dressing of examples 1-5 on the skin of 1-5 groups of volunteers respectively, and covering the iodophor with the liquid dressing; group 6 was a control group, and no dressing was applied. After film formation, the film was washed with running water for 1min, and the time for disappearance of iodophors was observed, and the results are shown in Table 2.
TABLE 2 disappearance of iodophors
According to the experimental results in table 2, the liquid dressing of the present invention has a good waterproof effect.
Therefore, the liquid dressing for wound protection, which is disclosed by the invention, can solve the problems of high price and skin irritation of the existing liquid dressing, and has the advantages of good waterproofness and quick film forming.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solutions of the present invention and not for limiting the same, and although the present invention is described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that: modifications and equivalents may be made to the invention without departing from the spirit and scope of the invention.
Claims (8)
1. The liquid dressing for wound protection is characterized by comprising the following components in percentage by mass: 3-18% of film forming agent, 82-97% of volatile solvent and 0-1% of auxiliary agent.
2. A liquid dressing for wound protection according to claim 1, wherein: the film forming agent is an acrylate copolymer.
3. A liquid dressing for wound protection according to claim 1, wherein: the volatile solvent is one or more of ethanol, isopropanol, polydimethylsiloxane, polyethyl phenyl methyl siloxane, hexamethyl disiloxane, isooctane, acetone and diethyl ether.
4. A liquid dressing for wound protection according to claim 1, wherein: the auxiliary agent is one or a mixture of more of a softening humectant, a plasticizer and an antibacterial agent.
5. A liquid dressing for wound protection according to claim 4, wherein: the softening humectant is one or a mixture of glycerol, liquid paraffin and sodium hyaluronate.
6. A liquid dressing for wound protection according to claim 4, wherein: the plasticizer is one or a mixture of triethyl citrate, tributyl citrate, isopropyl palmitate, glyceryl triacetate, dimethyl phthalate, diethyl phthalate, dibutyl phthalate and dibutyl sebacate.
7. A liquid dressing for wound protection according to claim 4, wherein: the antibacterial agent is one or more of water-soluble chitosan, vanillin antibacterial agent, ethyl vanillin antibacterial agent, anilide antibacterial agent, imidazole antibacterial agent, thiazole antibacterial agent, isothiazolone derivative antibacterial agent, quaternary ammonium salt antibacterial agent, biguanidine antibacterial agent, phenol antibacterial agent and chitin.
8. A method of manufacturing a liquid dressing for wound protection according to any one of claims 1 to 7, comprising the steps of:
s1, adding the volatile solvent into a liquid preparation tank, and stirring at the room temperature at the rotating speed of 500r/min for 5-20 min;
s2, heating the liquid preparation tank to 40-60 ℃, continuously stirring at the rotating speed of 500r/min, adding the film forming agent, and uniformly mixing;
s3, cooling to room temperature, and continuing stirring for 1-3h at the rotating speed of 800-;
s4, adding the auxiliary agent into the mixed liquid prepared in the step S3, stirring while adding the auxiliary agent, wherein the stirring speed during adding is 500r/min, and stirring for 60min at the rotating speed of 1000r/min after adding;
and S5, standing for 30min, and filling after bubbles completely disappear.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111621290.8A CN114225102A (en) | 2021-12-28 | 2021-12-28 | Liquid dressing for wound protection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111621290.8A CN114225102A (en) | 2021-12-28 | 2021-12-28 | Liquid dressing for wound protection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114225102A true CN114225102A (en) | 2022-03-25 |
Family
ID=80763769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111621290.8A Pending CN114225102A (en) | 2021-12-28 | 2021-12-28 | Liquid dressing for wound protection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114225102A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115160482A (en) * | 2022-07-26 | 2022-10-11 | 武汉工程大学 | Skin protection membrane material and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251720A (en) * | 2019-07-22 | 2019-09-20 | 陕西佰傲再生医学有限公司 | Liquid dressing and preparation method thereof |
| CN110559475A (en) * | 2019-09-19 | 2019-12-13 | 广州博民生物科技有限公司 | Compound liquid dressing and preparation method thereof |
| CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
| CN112274689A (en) * | 2019-07-24 | 2021-01-29 | 江苏昌吉永生物科技股份有限公司 | Waterproof wound-protecting liquid dressing and preparation method thereof |
-
2021
- 2021-12-28 CN CN202111621290.8A patent/CN114225102A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110251720A (en) * | 2019-07-22 | 2019-09-20 | 陕西佰傲再生医学有限公司 | Liquid dressing and preparation method thereof |
| CN112274689A (en) * | 2019-07-24 | 2021-01-29 | 江苏昌吉永生物科技股份有限公司 | Waterproof wound-protecting liquid dressing and preparation method thereof |
| CN110559475A (en) * | 2019-09-19 | 2019-12-13 | 广州博民生物科技有限公司 | Compound liquid dressing and preparation method thereof |
| CN112156224A (en) * | 2020-01-20 | 2021-01-01 | 海南海默斯医学生物科技有限公司 | Composition for preparing keratin liquid dressing and preparation method and application thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115160482A (en) * | 2022-07-26 | 2022-10-11 | 武汉工程大学 | Skin protection membrane material and preparation method and application thereof |
| CN115160482B (en) * | 2022-07-26 | 2023-11-17 | 武汉工程大学 | Skin protection film material and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112316205A (en) | External asiaticoside gel dressing and preparation method thereof | |
| CA2002404A1 (en) | Delivery system for pharmaceutical or therapeutic actives | |
| CN105411919A (en) | Skin caring product made from roses and preparation method thereof | |
| CN110251720A (en) | Liquid dressing and preparation method thereof | |
| CN114225102A (en) | Liquid dressing for wound protection and preparation method thereof | |
| CN107550753A (en) | A kind of composition and preparation method thereof with skin repair, anti-senescence function | |
| CN111228207B (en) | Dampness-rash-eliminating hip-protecting cream and preparation method thereof | |
| US20200376064A1 (en) | Use of a vegetal extract as an active agent in tissue re-epithelizing and cicatrizing processes | |
| CN112107724A (en) | Liquid dressing and preparation method thereof | |
| CN104840428A (en) | Hyaluronic acid-chitosan microsphere carrying epidermal growth factor and preparation method and application of hyaluronic acid-chitosan microsphere | |
| KR20210096056A (en) | A topical pharmaceutical composition for treating or preventing scar | |
| CN111643723B (en) | Liquid dressing containing icodextrin | |
| CN110507558B (en) | Wound repair hyaluronic acid mask liquid and preparation method thereof | |
| Chelu et al. | Aloe vera-based hydrogels for wound healing: properties and therapeutic effects. Gels. 2023; 9: 539 | |
| CN109224124B (en) | Liquid dressing for stopping bleeding and promoting healing | |
| KR20210060150A (en) | Wound dressing material composition and wound dressing material containing the same | |
| CN109432065A (en) | A kind of stealthy net acne patch of konjaku glucomannan | |
| CN105107013B (en) | A kind of floorboard with high oil content biological composite membrane and preparation method thereof | |
| CN104971345B (en) | Emodin gelatin microsphere and nano-silver composite gel preparation for treating burns and scalds | |
| CN113289055A (en) | Green liquid adhesive bandage with antibacterial function and preparation method thereof | |
| CN113041189A (en) | Antioxidant moisturizing essence body lotion and preparation method thereof | |
| CN106309489B (en) | A medicinal patch for relieving skin inflammation, and its preparation method | |
| CN1228054C (en) | Artificial skin powder prepn containing sodium hyaluronate and its prepn | |
| CN109865126A (en) | Wound surface nurses ointment and preparation method thereof | |
| CN115006337B (en) | Double-layer hydrophilic gel patch for repairing skin wound surface and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220325 |