KR20210060150A - Wound dressing material composition and wound dressing material containing the same - Google Patents

Abstract

The present invention relates to a wound dressing composition comprising: 20-60 parts by weight of polyurethane; 1-20 parts by weight of a silicone polymer; and the remaining solvent. The wound dressing composition according to the present invention protects a wound part and maintains a wet environment by being rapidly dried to form a film when coated on skin and alleviates itching, inflammation, and scarring caused by dry skin. In addition, the wound dressing composition according to the present invention has elasticity and flexibility after forming the film, can be maintained on a curved part of the skin for a long time, and allows contact with water such as light shower with a waterproof effect.

Description

Wound dressing material composition and wound dressing material containing the same}

The present invention relates to a wound coating composition and a wound coating material comprising the same, and more particularly, when applied to a wound, a film is formed to protect the wound area, and by maintaining a moist environment, itching or scarring caused by dry skin is relieved. It relates to a wound coating composition that can give and a wound coating material comprising the same.

Skin wounds have been known to heal from BC using animal oil, honey, and various plants. A variety of wet dressings have been developed since Winter published a paper in 1962 stating that keeping wounds wet is more beneficial for wound healing.

In addition, recently, liquid wound coverings for use in light abrasions of the skin have been developed and used. Here, nitrocellulose, polyurethane, polyvinylpyrrolidone or acrylate, etc. are mainly used. Water, ethyl acetate, alcohol, isooctane, and the like are used as a solvent for preparing such a liquid wound covering. However, it is known that the liquid wound coverings do not have a function of alleviating scars that may be caused by a wound, and do not have a function of alleviating itchiness or inflammation of a wound.

Meanwhile, in general, siloxane polymers are used in the form of creams and patches to alleviate the occurrence of scars caused by wounds. However, in the case of the cream, it is easily removed and it is difficult to act on the skin for a long time. In the case of the patch, there is a disadvantage that it does not adhere well to the curved part of the body and falls off easily.

Therefore, in order to solve the problems of the prior art described above, the inventors have repeatedly researched to develop a liquid wound covering material that can protect the wound area by forming a film when applied to a wound and maintain a moist environment. As a result, polyurethane and siloxane If a mixture of polymers can be dissolved in a solvent to prepare a homogeneous and stable solution that does not cause phase separation, the present invention has been completed by conceiving that it can be applied as a liquid wound coating material that can quickly dry and form a film when applied to skin. It came to the following.

Patent Document 1. Korean Registered Patent Publication No. 10-1879643 Patent Document 2. Korean Registered Patent Publication No. 10-0838428

Accordingly, the present invention has been conceived in view of the above problems, and an object of the present invention is to provide a liquid wound covering composition capable of protecting a wound area by forming a film when applied to a wound and maintaining a moist environment.

In addition, another object of the present invention is to provide a wound coating material having elasticity and flexibility, which is easy to apply to a curved part of the body or a complex three-dimensional skin by including the liquid wound coating composition.

The present invention for achieving the object as described above, 20 to 60 parts by weight of polyurethane; 1 to 20 parts by weight of a silicone polymer; It provides a wound covering composition comprising; and the remainder of the solvent.

The silicone polymer is any one or two selected from hexamethyldisiloxane (HMDSO), octamethyltrisiloxane (OMTSO), cyclopentasiloxane (CPSO), polydimethylsiloxane (PDMS), and hydroxy-terminated polydimethylsiloxane (HTPDMS). It is characterized in that it is a mixture of the above.

The solvent is water, methanol, ethanol, propanol, isopropanol, butanol, pentanol, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, isopentyl acetate, dimethyl ketone, methyl ethyl ketone, diethyl ketone, diisopropyl adipate. , Isopropyl myristate, isopropyl palmitate, mineral oil, pentane, hexane, heptane, octane, isooctane, nonane, decane, and isododecane.

The wound coating composition is characterized in that the viscosity is 50 ~ 1,000 cp, pH 4.5 ~ 6.5.

The wound covering composition is queensland nut oil, pine needle extract, gosam extract, okyongsan extract, menthol, peppermint, mint, emu oil, beta glucan, Eoseongcho extract, ginseng extract, elm root extract, broccoli extract, gosam extract, sesame fruit Extract, Portulaca oleracea extract, Burdock extract, Calendula extract, Chamomile extract, Papaya extract, Angelicae extract, Siho extract, Macmundong extract, Cheonmundong extract, Aloes extract, Centella asiatica extract, Licorice extract, Audi extract, Sangbaek skin extract, Green tea extract Flower extract, aloe vera leaf extract, herbal extract, licorice extract, olive oil, jojoba seed oil, camellia flower oil, almond oil, rosemary leaf extract, pine extract, sharon seed extract, thistle extract, hydroxyethylurea, ceramide, 1, It is characterized in that it further comprises at least one component selected from the group consisting of 3-butyrene, 1,2-hexanediol, and betaine.

In addition, the present invention provides a wound covering material comprising the wound covering composition.

When the wound coating composition according to the present invention is applied to the skin, it dries quickly to form a film, thereby protecting the wound area and maintaining a moist environment, and can relieve itching and inflammation caused by dry skin, as well as the occurrence of scars. In addition, since the wound covering composition according to the present invention has elasticity and flexibility after film formation, it can be maintained for a long time in a curved part of the skin, and has a waterproof effect, so that it is possible to contact with water such as a light shower.

Hereinafter, the wound coating composition according to the present invention and the wound coating material including the same will be described in detail with examples and comparative examples.

First, in the present invention, 20 to 60 parts by weight of polyurethane; 1 to 20 parts by weight of a silicone polymer; It provides a wound covering composition comprising; and the remainder of the solvent.

In general, polyurethane is a biomaterial that has been most widely used as a medical polymer material over the past several decades because it is flexible and has high mechanical strength. It is widely known to be used as a material such as artificial organs due to its excellent blood and tissue compatibility. In addition, silicone polymers are also proven polymer materials that are most commonly used in the human body, and have various formulations from liquid to solid depending on molecular weight and degree of crosslinking. In addition, it has excellent blood compatibility and is also widely used as a material such as artificial organs.

Therefore, in the present invention, a polyurethane and a silicone polymer are used as the main material of the wound covering composition, and the polyurethane may be a commercially available product of medical grade.

In addition, the silicone polymer is any one selected from hexamethyldisiloxane (HMDSO), octamethyltrisiloxane (OMTSO), cyclopentasiloxane (CPSO), polydimethylsiloxane (PDMS), and hydroxy-terminated polydimethylsiloxane (HTPDMS). Or it may be a mixture of two or more.

In particular, when using a mixture of two as the silicone polymer, one having a high molecular weight having a molecular weight in the range of 200,000 to 1,000,000, and the other having a low molecular weight silicone polymer having a range of 100 to 5,000 is adopted as a liquid wound coating composition. It is more preferable because it can maximize the effect of reducing scars while controlling the viscosity of the skin.

At this time, a solvent is used to obtain a uniform solution by dissolving polyurethane and silicone polymer to form a liquid wound coating composition. As the solvent, water, methanol, ethanol, propanol, isopropanol, butanol, pentanol, Methyl acetate, ethyl acetate, propyl acetate, butyl acetate, isopentyl acetate, dimethyl ketone, methyl ethyl ketone, diethyl ketone, diisopropyl adipate, isopropyl myristate, isopropyl palmitate, mineral oil, pentane, hexane, Any one or two or more mixed solvents selected from heptane, octane, isooctane, nonane, decane, and isododecane are preferably used.

The liquid wound coating composition according to the present invention is preferably formed of 20 to 60 parts by weight of the polyurethane, 1 to 20 parts by weight of the silicone polymer, and the remainder of the solvent as a liquid band-type wound coating material. Can be manufactured.

The liquid wound covering composition formed as described above has a viscosity of 50 to 1,000 cp and a pH of 4.5 to 6.5. When applied to the skin, it dries quickly and forms a film to protect the wound area and maintain a moist environment. It is more preferable because it can relieve itching and inflammation, and scarring.

In addition, the wound covering composition according to the present invention may further contain functional ingredients to obtain itchiness or inflammation relief, skin soothing, disinfecting and moisturizing effects, etc., for alleviating itching, Queensland nut oil, pine needle extract, high ginseng extract, Okyongsan extract, menthol, peppermint or mint, emu oil, beta-glucan, Eoseongcho extract, ginseng extract, elm tree root extract, broccoli extract, gosam extract, perilla fruit extract, mascot extract, burdock extract, calendula extract, Chamomile extract, papaya extract, angelica extract, siho extract, licorice extract, astronomical dong extract or aloe vera extract, centella asiatica extract, licorice extract, mulberry extract for skin soothing, lettuce extract, green tea extract, matricaria flower extract, aloe vera , Herb extract, licorice essence, olive oil, jojoba seed oil, camellia flower oil, almond oil, rosemary leaf extract, pine extract, sharon seed extract, thistle extract, hydroxyethylurea, ceramide, 1,3-butyrene for moisturizing It is preferable to further include at least one component selected from the group consisting of 1,2-hexanediol and betaine.

In addition, in the present invention, it is possible to provide a wound covering material by molding into a liquid band type according to a known method, including the wound covering composition described above.

Hereinafter, specific examples according to the present invention will be described in detail together with comparative examples.

[Example]

(Production Example 1-5)

A liquid wound coating composition was formed in which various silicone polymers shown in Table 1 below were mixed in a polyurethane solution (40% by weight, solvent: ethanol/isopropyl palmitate).

Manufacturing example Polyurethane content (parts by weight) Silicone polymer content (parts by weight) Manufacturing Example 1 10 0.3 (PDMS) Manufacturing Example 2 10 0.3 (HTPDMS) Manufacturing Example 3 10 0.3 (HMDSO) Manufacturing Example 4 10 0.3 (OMTSO) Manufacturing Example 5 10 0.3 (CPSO)

(Production Example 6-10)

To the liquid wound coating composition obtained from Preparation Example 1, various inflammation alleviating components shown in Table 2 were added to form a liquid wound coating composition.

Manufacturing example Composition content of Preparation Example 1 (parts by weight) Inflammation relief component content (parts by weight) Manufacturing Example 6 10.3 0.043 (emu oil) Manufacturing Example 7 10.3 0.043 (betaglucan) Manufacturing Example 8 10.3 0.043 (Eoseongcho extract) Manufacturing Example 9 10.3 0.043 (Gosam extract) Manufacturing Example 10 10.3 0.043 (chamomile extract)

(Production Example 11-15)

A liquid wound coating composition was formed by adding various itching relief ingredients shown in Table 3 below to the liquid wound coating composition obtained from Preparation Example 10.

Manufacturing example Composition content of Preparation Example 10 (parts by weight) Content of itching relief ingredients (parts by weight) Manufacturing Example 11 10.343 0.02 (Queensland Nut Oil) Manufacturing Example 12 10.343 0.02 (pine needle extract) Manufacturing Example 13 10.343 0.02 (menthol) Manufacturing Example 14 10.343 0.02 (Okyongsan extract) Manufacturing Example 15 10.343 0.02 (mint)

(Production Example 16-20)

Various skin soothing ingredients shown in Table 4 below were added to the liquid wound coating composition obtained from Preparation Example 11 to form a liquid wound coating composition.

Manufacturing example Composition content of Preparation Example 11 (parts by weight) Skin soothing ingredient content (parts by weight) Manufacturing Example 16 10.363 0.04( Centella asiatica extract) Manufacturing Example 17 10.363 0.04 (Liquorice extract) Manufacturing Example 18 10.363 0.04 (green tea extract) Manufacturing Example 19 10.363 0.04 (Aloe vera extract) Manufacturing Example 20 10.363 0.04(Angelicae extract)

(Production Example 21-25)

Various moisturizing components shown in Table 5 below were added to the liquid wound coating composition obtained from Preparation Example 16 to form a liquid wound coating composition.

Manufacturing example Composition content of Preparation Example 16 (parts by weight) Moisturizing ingredient content (parts by weight) Manufacturing Example 21 10.403 0.04 (olive oil) Manufacturing Example 22 10.403 0.04(Jojoba seed oil) Manufacturing Example 23 10.403 0.04 (camellia flower oil) Manufacturing Example 24 10.403 0.04 (hydroxyethylurea) Manufacturing Example 25 10.403 0.04 (ceramide)

The liquid wound covering composition obtained from Preparation Examples 1 to 20 has a pale yellow color, is a transparent and viscous solution, and can be stored and used in a glass container formed of a brush or spatula type can that is easy to apply to the skin.

(Test Example)

The liquid wound covering composition obtained from Preparation Example 21 was cast and completely dried to prepare a film-shaped wound covering, and a film prepared from the thus prepared film-shaped wound covering and the conventional liquid band commercialized (Comparative Example 1: Polyurethane-based, Comparative Example 2: nitrocellulose-based) were measured for tensile strength, elongation and moisture permeability (WVTR @36°C), and the results are shown in Table 6 below.

Properties Test example Comparative Example 1 Comparative Example 2 Tensile strength (Mpa) 13.7 19.2 8.5 Elongation (%) 711.64 768.3 35.65 WVTR(g/m ² day) 2,040 1,240 300 pH* 4.85 7.87 3.01

*pH is the measured value of the liquid wound covering composition

As shown in Table 6, the wound coating material prepared from the liquid wound coating composition according to the present invention not only has excellent mechanical properties such as tensile strength and elongation, but also has a greater moisture permeability compared to the commercially available conventional products, resulting in a wet environment. It can maintain, and by the addition of various functional ingredients, itching and inflammation can be relieved, moisturizing and skin soothing effects can be obtained.

Claims (6)

20 to 60 parts by weight of polyurethane;
1 to 20 parts by weight of a silicone polymer; And
The balance of the solvent; wound coating composition containing. The method of claim 1, wherein the silicone polymer is hexamethyldisiloxane (HMDSO), octamethyltrisiloxane (OMTSO), cyclopentasiloxane (CPSO), polydimethylsiloxane (PDMS), and hydroxy-terminated polydimethylsiloxane (HTPDMS). Wound coating composition, characterized in that any one or a mixture of two or more selected from. The method of claim 1, wherein the solvent is water, methanol, ethanol, propanol, isopropanol, butanol, pentanol, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, isopentyl acetate, dimethyl ketone, methyl ethyl ketone, diethyl ketone. , Diisopropyl adipate, isopropyl myristate, isopropyl palmitate, mineral oil, pentane, hexane, heptane, octane, isooctane, nonane, decane, and isododecane. The wound covering composition. The wound coating composition according to claim 1, wherein the wound coating composition has a viscosity of 50 to 1,000 cp and a pH of 4.5 to 6.5. The method of claim 1, wherein the wound covering composition is Queensland nut oil, pine needle extract, gosam extract, Okyongsan extract, menthol, mint, mint, emu oil, beta glucan, Eoseongcho extract, ginseng extract, elm tree root extract, broccoli extract , Sophora ginseng extract, Japanese ginseng fruit extract, portulaca oleracea extract, burdock extract, calendula extract, chamomile extract, papaya extract, angelica extract, shiho extract, licorice extract, cheonmundong extract, aloes extract, centella extract, mulberry extract, licorice extract Green Tea Extract, Matricaria Flower Extract, Aloe Vera Leaf Extract, Herb Extract, Licorice Extract, Olive Oil, Jojoba Seed Oil, Camellia Flower Oil, Almond Oil, Rosemary Leaf Extract, Pine Extract, Mugunghwa Seed Extract, Thistle Extract, Hydroxyethyl Urea, ceramide, 1,3-butyrene, 1,2-hexanediol, and wound coating composition, characterized in that it further comprises at least one component selected from the group consisting of betaine. The wound coating material comprising the wound coating composition of any one of claims 1 to 5.