KR102510213B1 - The adhesive transparent wound covering material composition containing fumaria officinalis, pomegranate shell extract and comfrey leaf extract - Google Patents

Abstract

The present invention relates to an adhesive transparent wound covering material composition containing extracts of Fumaria officinalis, pomegranate peel, and comfrey leaves, which comprises purified water, ethanol, β-glucan, a Fumaria officinalis extract, a pomegranate peel extract, a comfrey leaf extract, panthenol, 1,2-hexanediol, 1,3-butylene glycol, ethylhexylglycerin, allantoin, disodium EDTA, and ammonium acryloyldimethyltaurate. According to the present invention, the adhesive transparent wound covering material composition comprising a natural extract such as a Fumaria officinalis extract, a Pomegranate peel extract, and a comfrey leaf extract and the like can protect an area with damaged skin barrier, such as dry skin and scalp, form a physical film on the skin and scalp where the skin barrier is broken, and maintain moisture in a skin environment to relive itchiness and scarring caused by dry skin.

Description

The adhesive transparent wound covering material composition containing fumaria officinalis, pomegranate shell extract and comfrey leaf extract}

The present invention relates to an adhesive transparent wound covering composition containing a coriander extract, a pomegranate peel extract, and a comfrey leaf extract, and more particularly, to protect areas where the skin barrier is damaged, such as dry skin and scalp, where the skin barrier is broken. It relates to an adhesive transparent wound covering composition containing corydalis extract, pomegranate peel extract, and comfrey leaf extract capable of forming a physical film on the skin and scalp and retaining moisture in the skin environment.

A wound is a state in which the continuity of tissue is destroyed by external pressure or a defect occurs in some area. Mild wounds such as simple trauma can be regenerated by self-healing function, but it is difficult to completely repair intractable wounds such as severe burns, complex wounds, bedsores, and surgical wounds. Intractable wounds or extensive wounds may leave defects in the functioning of the tissue, so treatment to quickly treat the wound and minimize various secondary side effects is essential.

It is known that the healing rate of wounds is about twice as fast when they are kept wet than when they are dry. Therefore, conventionally, a method of dressing with gauze soaked in a physiological solution or a solution containing a disinfectant has been used to maintain a wet state. However, this is cumbersome to manage because the dressing replacement cycle must be frequent, and not only the wound area but also the surrounding area is kept wet by a physiological solution or disinfectant, causing soreness of the skin.

Recently, a method of protecting the affected area using a wound covering material such as a hydrogel or a hydrocolloid, preventing water leakage from the body and absorbing exudate to maintain a moist environment has been widely used. However, there is a disadvantage in that it does not adhere well to the curved parts of the body and easily falls off, or a wound covering material suitable for the size of each used part must be used or cut.

In addition, liquid wound covering materials for use on light abrasions and the like of the skin have been developed and used. Here, nitrocellulose, polyurethane, polyvinylpyrrolidone or acrylate are used as main materials. Water, ethyl acetate, isooctane, etc. are used as solvents for preparing such liquid wound coating materials. known to be lacking.

Therefore, in order to protect the skin and scalp where the skin barrier is damaged, it contains natural extracts that are non-cytotoxic and non-irritating to form a physical film on the skin and scalp where the skin barrier is destroyed and to maintain moisture in the skin environment. There is a need to develop an adhesive transparent wound covering composition.

KR 10-2021-0060150 A(2021. 05. 26.)

The present invention has been made to solve the problems of the prior art, and the problem to be solved in the present invention is to form a physical film on the skin and scalp where the skin barrier is destroyed, and to maintain moisture in the skin environment. An object of the present invention is to provide an adhesive transparent wound covering composition containing comb corydalis extract, pomegranate peel extract and comfrey leaf extract.

Another object is to provide an adhesive transparent wound covering composition containing Corydalis extract, pomegranate peel extract and comfrey leaf extract that is easy to apply to curved parts of the body or skin with a complex three-dimensional structure and has elasticity and flexibility. It has a purpose.

In order to achieve the above object, the adhesive transparent wound covering composition containing corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention is purified water, ethanol, β-glucan, round comb Corydalis extract, pomegranate peel extract, comfrey leaf extract, panthenol, 1,2-hexanediol, 1,3-butylene glycol, ethylhexyl glycol It is characterized by including serine (Ethylhexylglycerin), allantoin, disodium EDTA and ammonium acryloyldimethyltaurate (Ammonium Acryloyldimethyltaurate).

In addition, with respect to 100 parts by weight of the purified water, 10 to 20 parts by weight of ethanol, 7 to 15 parts by weight of beta-glucan, 2 to 3 parts by weight of Corydalis extract, 3 to 5 parts by weight of pomegranate peel extract Comfrey leaf extract 1-2 parts by weight, panthenol 7-15 parts by weight, 1,2-hexanediol 2-5 parts by weight, 1,3-butylene glycol (1 ,3-Butylene glycol) 1-3 parts by weight, Ethylhexylglycerin 0.05-0.1 parts by weight, Allantoin 0.03-0.1 parts by weight, Disodium EDTA 0.01-0.05 parts by weight, and Characterized in that it comprises 1 to 3 parts by weight of ammonium acryloyldimethyltaurate (Ammonium Acryloyldimethyltaurate).

In addition, with respect to 100 parts by weight of the purified water, it is characterized in that it further comprises 3 to 7 parts by weight of a mixture obtained by mixing equal amounts of horseradish root extract, licorice extract, cnidium extract, eggplant extract, peony extract and epilobium place skerry extract.

In addition, the adhesive transparent wound coating composition containing the coriander extract, pomegranate peel extract and comfrey leaf extract is characterized in that it is formed at a viscosity of 300 to 7,000 cPs and a pH of 4 to 7.

According to the present invention, through an adhesive transparent wound covering composition containing natural extracts such as chamomile extract, pomegranate peel extract, and comfrey leaf extract, it protects areas where the skin barrier is damaged, such as dry skin and scalp, and the skin barrier is destroyed. And it forms a physical film on the scalp, and has an effect of relieving itching or scarring due to dry skin by maintaining moisture in the skin environment.

1 to 5 are photos before and after scalp application of an adhesive transparent wound coating material (Example 1) prepared using an adhesive transparent wound coating composition containing corydalis corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention am.
6 to 10 are photos before and after scalp application of the adhesive transparent wound coating material (Example 2) prepared using the adhesive transparent wound coating composition containing corydalis corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention am.

Hereinafter, the present invention will be described in detail.

In order to protect areas where the skin barrier is damaged, such as the skin and scalp, the present invention forms a physical film on the skin and scalp where the skin barrier is destroyed, and contains Corydalis extract, pomegranate rind extract, and It is intended to provide an adhesive transparent wound covering composition containing comfrey leaf extract, and the present invention is to provide purified water, ethanol, beta-glucan, corydalis chamomile extract, pomegranate peel extract, comfrey leaf extract, panthenol (panthenol), 1,2-hexanediol, 1,3-butylene glycol, ethylhexylglycerin, allantoin, disodium It is composed of disodium EDTA and ammonium acryloyldimethyltaurate.

More specifically, based on 100 parts by weight of purified water, 10 to 20 parts by weight of ethanol, 7 to 15 parts by weight of beta-glucan, 2 to 3 parts by weight of Corydalis extract, 3 to 3 parts by weight of pomegranate peel extract 5 parts by weight, comfrey leaf extract 1-2 parts by weight, panthenol 7-15 parts by weight, 1,2-hexanediol 2-5 parts by weight, 1,3-butylene glycol (1,3-Butylene glycol) 1-3 parts by weight, Ethylhexylglycerin 0.05-0.1 parts by weight, Allantoin 0.03-0.1 parts by weight, Disodium EDTA 0.01-0.05 parts by weight part and ammonium acryloyldimethyltaurate (Ammonium Acryloyldimethyltaurate) 1 to 3 parts by weight.

The adhesive transparent wound covering composition containing corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention is purified water, ethanol, beta-glucan, corydalis extract, pomegranate peel extract, comfrey Leaf extract, panthenol, 1,2-hexanediol, 1,3-butylene glycol, ethylhexylglycerin, allantoin ), disodium EDTA, and Ammonium Acryloyldimethyltaurate, each unique effective ingredient harmonizes with each other and complements each other, so that each ingredient can be used alone or only some of the ingredients can be used. It cannot be obtained by mixing.

First, in order to form an adhesive transparent wound coating composition containing corydalis extract, pomegranate peel extract and comfrey leaf extract in liquid form, a solvent is used to obtain a uniform solution by dissolving other compositions, the solvent As water, ethanol, methanol, propanol, isopropanol, butanol, pentanol, methyl acetate, ethyl acetate, propyl acetate, butyl acetate, isopentyl acetate, dimethyl ketone, methyl ethyl ketone, diethyl ketone, diisopropyl adipate, Any one selected from isopropyl palmitate, pentane, hexane, heptane, octane, isooctane, nonane, decane, and isododecane, or a mixed solvent of two or more may be used.

In the present invention, a mixture of purified water and ethanol is used.

If purified water and ethanol are used in less than the above range, it is difficult to sufficiently dissolve other compositions and it is difficult to obtain a uniform solution.

Beta-glucan is a high molecular component composed of several glucoses extracted from the cell walls of yeasts such as mushrooms, oats, barley, and seaweed. It induces the secretion of angiogenic factors and has excellent skin healing and anti-aging effects that regenerate normal new skin. play a role

If beta-glucan is included in an amount less than the above range, the effect is insignificant, and if it is included in an amount exceeding the above range, physical properties may deteriorate due to a content greater than necessary.

First, the method for preparing the extracts used in the present invention is not particularly limited, and may be performed by conventional methods known in the art, such as solvent extraction, hot water extraction, reflux cooling extraction, ultrasonic extraction and filtration.

In the present invention, extraction is performed through solvent extraction using an organic solvent, and the organic solvent used for this purpose may be selected from ethanol, methanol, butanol, ether, ethyl acetate, chloroform or a mixture of these organic solvents, preferably 70% to use ethanol.

First, Corydalis Corydalis extract is prepared by washing, drying, and pulverizing Corydalis Corydalis, extracting by adding a solvent, filtering, concentrating under reduced pressure, and freeze-drying.

More specifically, 500 to 1,000 parts by weight of 70% ethanol was mixed with 100 parts by weight of 100 parts by weight of 100 parts by weight of 100 parts by weight of corystal, which was washed, dried to a moisture content of 5% by weight or less, and pulverized to a size of 100 to 200 mesh. It is prepared by repeatedly extracting 2 to 5 times for 4 hours, filtering, concentrating with a rotary evaporator, and freeze-drying.

Here, if the extraction temperature and extraction time are out of range, the extraction efficiency may decrease or the components may change.

Preferably, 700 parts by weight of 70% ethanol is mixed with 100 parts by weight of 100 parts by weight of Corydalis, which is washed, dried to a water content of 5% by weight or less, and pulverized to a size of 150 mesh, extracted three times for 3 hours at 70 ° C, and filtered. After that, it is concentrated with a rotary evaporator and lyophilized for 72 hours to make a powder with a size of 300 mesh.

Round comb corydalis (Fumaria officinalis) is an annual plant of the dicotyledonous poppy plant Papaveraceae, and is effective in moisturizing the skin and improving the skin barrier.

If the Corydalis chamomile extract is included in an amount less than the above range, the skin moisturizing and skin barrier improvement effects are insignificant, and if it is included in an amount exceeding the above range, the physical properties may be deteriorated due to the content more than necessary.

Pomegranate peel extract is prepared by washing, drying and pulverizing pomegranate peel, extracting by adding a solvent, filtering, concentrating under reduced pressure, and freeze-drying.

More specifically, 500 to 1,000 parts by weight of 70% ethanol was mixed with 100 parts by weight of pomegranate peel, which was washed, dried to a moisture content of 5% by weight or less, and pulverized to a size of 100 to 200 mesh. After repeated extraction and filtration 2 to 5 times over time, it is prepared by concentrating with a rotary evaporator and freeze-drying.

Here, if the extraction temperature and extraction time are out of range, the extraction efficiency may decrease or the components may change.

Preferably, 700 parts by weight of 70% ethanol is mixed with 100 parts by weight of pomegranate peel, which is washed, dried to a water content of 5% by weight or less, and pulverized to a size of 150 mesh, extracted three times for 3 hours at 70 ° C, and filtered. Then, it is concentrated with a rotary evaporator and lyophilized for 72 hours to make a powder with a size of 300 mesh.

Pomegranate peel has skin astringent and beauty effects, and at the same time, it is effective against skin harmful bacteria such as Staphylococcus aureus, Pseudomonas epidermis, acne-causing bacteria, Propionibacterium acnes, and Escherichia coli (E. coli), etc., it can prevent skin troubles, and it has pharmacological action to inhibit insecticide, dysentery, etc., and to inhibit influenza bacillus and skin fungus.

If the pomegranate peel extract is contained in an amount less than the above range, the skin moisturizing and skin astringent and antibacterial effects are insignificant, and if it is contained in an amount exceeding the above range, the physical properties may be deteriorated due to the content more than necessary.

Comfrey leaf extract is prepared by washing, drying and pulverizing comfrey leaves, extracting by adding a solvent, filtering, concentrating under reduced pressure, and freeze-drying.

More specifically, 500 to 1,000 parts by weight of 70% ethanol was mixed with 100 parts by weight of comfrey leaves washed, dried to a moisture content of 5% by weight or less, and pulverized to a size of 100 to 200 mesh, followed by 2 to 4 parts by weight at 60 to 80 ° C. After repeated extraction and filtration 2 to 5 times over time, it is prepared by concentrating with a rotary evaporator and freeze-drying.

Here, if the extraction temperature and extraction time are out of range, the extraction efficiency may decrease or the components may change.

Preferably, 700 parts by weight of 70% ethanol was mixed with 100 parts by weight of comfrey leaves washed, dried to a moisture content of 5% by weight or less, and pulverized to a size of 150 mesh, extracted three times for 3 hours at 70 ° C, and filtered. Then, it is concentrated with a rotary evaporator and lyophilized for 72 hours to make a powder with a size of 300 mesh.

Comfrey contains ingredients that are not found in general plants, such as allantoin and germanium, along with various vitamin ingredients. In particular, allantoin promotes the growth of new cells to help relieve skin itchiness and skin irritation, soothe, anti-allergic, antibacterial, It is effective in antioxidant and bactericidal action.

If comfrey leaf extract is contained in an amount less than the above range, the efficacy of skin itching, skin irritation relief, soothing, anti-allergy, antibacterial, antioxidant and bactericidal action is insignificant, and if it is contained in excess of the above range, it is more than necessary. Due to the content, physical properties may rather deteriorate.

Panthenol is a viscous transparent liquid at room temperature. It is an alcohol analog of pantothenic acid and is a provitamin of B5. It is used as a moisturizer, humectant and softener in pharmaceuticals and cosmetics. And it serves to accelerate the healing rate of epithelial wounds.

If panthenol is included below the above range, the role of relieving itching and inflammation of the skin, supplying moisture, improving elasticity, and accelerating the healing rate of epithelial wounds is insignificant. Due to the above content, the physical properties may rather deteriorate.

1,2-hexanediol (1,2-Hexanediol) has both hydrophobic and hydrophilic properties and has the structure of a surfactant. , Not only does it act as a preservative, but it also mixes well with water and has emulsifying properties in oil components, so it helps active ingredients that do not mix well with water to mix well, thereby enhancing stability.

If 1,2-hexanediol is included below the above range, it is difficult to increase the overall stability in addition to the role of a moisturizer, preservative and preservative. may be lowered

1,3-Butylene glycol (1,3-Butylene glycol) is a viscous liquid with an odorless sweetness. It has wettability, solubility and antibacterial properties. It has little irritation or toxicity to the skin. It absorbs moisture from the air. It has the ability to attract moisture and keeps the skin moist, so it has high moisturizing power. In addition, the glycol component has a high preservative function, so it supplements the preservative function.

If 1,3-butylene glycol is included in an amount less than the above range, it is difficult to sufficiently act as a moisturizing agent and preservative, and if it is included in an amount exceeding the above range, the physical properties may be deteriorated due to the content more than necessary. .

Ethylhexylglycerin is an organic compound of alcohol as a glyceryl ether component. It improves dry and damaged skin moisturization, has a deodorizing effect that inhibits the growth of anaerobic bacteria that cause odor, and plays a role in increasing antibacterial power. do.

If ethylhexylglycerin is included below the above range, it is difficult to sufficiently increase the moisturizing power, deodorizing effect, and antibacterial power, and when it is included in excess of the above range, the physical properties may deteriorate due to the content more than necessary.

Allantoin is an active moisturizing ingredient that is a naturally derived ingredient that can be extracted from various plants such as comfrey and sugar beet. It has anti-allergic and anti-inflammatory properties.

If allantoin is included in an amount less than the above range, it is difficult to sufficiently enhance the regenerative effect, soothing effect, anti-allergy and anti-inflammatory function, and if it is included in an amount exceeding the above range, the physical properties may deteriorate due to the content more than necessary. there is.

Disodium EDTA is a sequestering agent for metal ions. It dissolves well in water and prevents metal ions or products from being corroded or rancid due to mixing of air over time, so that oxides and harmful substances are not generated. It acts as a catalyst and prevents discoloration to help the composition permeate into the skin and be well absorbed.

If disodium EDTA is included below the above range, it is difficult to sufficiently perform the role of catalyst and discoloration prevention, and when it is included beyond the above range, physical properties may deteriorate due to the content more than necessary. .

Ammonium Acryloyldimethyltaurate (Ammonium Acryloyldimethyltaurate) is UV-stable, functions in a wide pH range, is soluble in water, and has excellent dispersibility.

If ammonium acryloyldimethyltaurate is included in an amount less than the above range, the dispersing ability is not sufficiently exhibited, making it difficult to adjust the viscosity to a desired level. this may deteriorate.

The viscosity of the adhesive transparent wound coating composition containing the corydalis extract, pomegranate peel extract, and comfrey leaf extract of the present invention as described above may be formed at a viscosity of 300 to 7,000 cPs and a pH of 4 to 7.

Through this, when applied to the skin and scalp, etc., it dries quickly to form a film to protect the damaged area, maintain a moist environment, and relieve itching, inflammation, and scarring caused by dry skin.

If the viscosity of the adhesive transparent wound covering composition containing the corydalis extract, pomegranate peel extract, and comfrey leaf extract of the present invention as described above is less than 300 cPs, it is not easy to apply to the skin and scalp, and evenly applied to the necessary area. It may not be applied, and if it exceeds 7,000 cPs, a problem in that it is not easy to form a film occurs when applied to the skin or scalp.

In the present invention, the purified water may be further included by mixing equal amounts of algae root extract, licorice extract, cnidaria extract, forsythia extract, peony extract, and epilobium place skerry extract.

More specifically, it further comprises 3 to 7 parts by weight of a mixture obtained by mixing equal amounts of horseradish root extract, licorice extract, cnidium extract, palm tree extract, peony extract and epilobium place keri extract with respect to 100 parts by weight of the purified water.

Through this, moisturizing, nutrition, and conditioning are further imparted to the adhesive transparent wound covering composition containing the Corydalis extract, pomegranate peel extract, and comfrey leaf extract of the present invention to protect damaged areas of the skin and scalp, maintain a moist environment, , itching and inflammation due to dry skin, it is possible to promote the alleviation of scarring.

The algae root extract, licorice extract, cnidium extract, eggplant extract, and peony extract are prepared by washing, drying, pulverizing, extracting by adding a solvent, filtering, concentrating under reduced pressure, and freeze-drying.

More specifically, 500 to 1,000 parts by weight of 70% ethanol is mixed with 100 parts by weight of each root, licorice, cnidium, branch, and peony that are washed, dried to a moisture content of 5% by weight or less, and pulverized to a size of 100 to 200 mesh. After repeated extraction and filtration 2 to 5 times for 2 to 4 hours at 60 to 80 ° C., concentrated with a rotary evaporator and freeze-dried.

Preferably, 700 parts by weight of 70% ethanol was mixed with 100 parts by weight of each root, licorice, cnidium, branch, and peony that were washed and dried to a moisture content of 5% by weight or less and pulverized to a size of 150 mesh, followed by mixing 3 parts by weight of 70% ethanol at 70 ° C. After repeated extraction and filtration three times over time, the mixture was concentrated with a rotary evaporator and lyophilized for 72 hours to make a powder with a size of 300 mesh.

For skin that is sensitive to skin irritation caused by surfactants and preservatives, galgeun relieves irritation and soothes the skin, and its main ingredient, flavonoids, manages the skin, suppresses active oxygen, which is the cause of skin aging, and prevents skin oxidation. It provides nutrition and conditioning to help vitality and vitality.

Licorice has antioxidant and whitening effects through the containment of isoliquiritigenin, a large amount of polyphenol component.

Cnidium has a unique fragrance, protects the skin by suppressing active oxygen through antioxidant action, and blocks moisture evaporation of the skin, thereby providing moisturizing power and providing skin conditioning effect.

Jisil has a unique fragrance, protects the skin by suppressing active oxygen through antioxidant action, and blocks pore contraction and moisture evaporation of the skin, thereby providing moisturizing power and having skin conditioning effects.

Peony has soothing, anti-inflammatory and antibacterial action through peonyflorin component, has anti-aging effect by promoting activation of collagen fiber, and has effect of protecting skin by suppressing active oxygen through antioxidant action.

Epilobium place cheri extract is extracted from the outpost of Epilobium fleischeri, and helps to shrink pores by controlling conditioning agents, astringents, and sebum.

If a mixture containing equal amounts of horseradish root extract, licorice extract, cnidium extract, eggplant extract, peony extract, and epilobium placellary extract is included in an amount less than the above range, each effect is insignificant, and the above range If it is included in excess, each unique scent can be strengthened to give a sense of rejection, and due to the content more than necessary, physical properties may rather deteriorate.

According to the present invention, through an adhesive transparent wound covering composition containing natural extracts such as chamomile extract, pomegranate peel extract, and comfrey leaf extract, it protects areas where the skin barrier is damaged, such as dry skin and scalp, and the skin barrier is destroyed. And it forms a physical film on the scalp, and has an effect of relieving itching or scarring due to dry skin by maintaining moisture in the skin environment.

Hereinafter, the present invention will be described in more detail through examples. However, it is clear to those skilled in the art that the following examples are only intended to specifically illustrate the present invention and do not limit the scope of the present invention. That is, simple modifications or changes of the present invention can be easily performed by a person skilled in the art, and all such modifications or changes can be considered to be included in the scope of the present invention.

An adhesive transparent wound covering material was prepared with the components shown in Table 1 below.

Ingredients (parts by weight) Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Purified water 100 100 100 100 100 100 100 100 100 100 ethanol 15 15 15 15 15 15 15 15 15 15 beta glucan 10 10 10 10 10 10 10 10 10 10 Round Comb Corydalis Extract 2.5 2.5 2.5 - - 2.5 2.5 - - 4 Pomegranate Peel Extract 4 4 - 4 - 4 - 4 - 7 Comfrey Leaf Extract 1.5 1.5 - - 1.5 - 1.5 1.5 - 3 panthenol 10 10 10 10 10 10 10 10 10 10 1,2-Hexanediol 3 3 3 3 3 3 3 3 3 3 1,3-butylene glycol 2 2 2 2 2 2 2 2 2 2 Ethylhexylglycerin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 allantoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Disodium EDT 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 0.03 Ammonium Acryloyl Dimethyl Taurate 2 2 2 2 2 2 2 2 2 2 Almond root extract, licorice extract, cnidium extract, branch extract, peony extract, and epilobium placercery extract - 5 - - - - - - - -

Based on the composition of Table 1, each component was evenly mixed and stirred to dissolve at 60 to 70 ° C. Then, it was cooled at room temperature to prepare an adhesive transparent wound covering material.

Experiment: Clinical trial

(1) Measurement of interfollicular erythema and follicular erythema pustules on the scalp

Scalp improvement through the adhesive transparent wound covering material (Examples 1 and 2) and Comparative Examples 1 to 8 prepared using the adhesive transparent wound covering composition containing the corydalis corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention In order to verify the effect, AI-Scalp grader was used to measure erythema between hair follicles and erythema follicular pustules on the scalp quantitatively.

The AI-Scalp grader was tested before application and 4 weeks after application on a total of 8 people with more than 1 point on a scale of 0 to 3 (0 normal, 1 mild, 2 moderate, 3 severe), that is, more than mild symptoms, and the results are shown in the table 2 and Table 3.

<Erythema between the hair follicles of the scalp> Before application 4 weeks after application Erythema between hair follicles Example 1 2.0 0.3 56% improvement Example 2 2.3 0.5 60% improvement Comparative Example 1 2.3 1.6 23% improvement Comparative Example 2 1.6 0.6 33% improvement Comparative Example 3 1.8 1.0 26% improvement Comparative Example 4 2.3 1.1 40% improvement Comparative Example 5 2.3 1.0 43% improvement Comparative Example 6 2.6 1.3 43% improvement Comparative Example 7 2.3 2.0 10% improvement Comparative Example 8 2.3 0.6 56% improvement

<Follicular erythema pustules of the scalp> Before application 4 weeks after application follicular erythema pustules Example 1 2.3 0.6 56% improvement Example 2 2.3 0.4 63% improvement Comparative Example 1 2.3 1.3 33% improvement Comparative Example 2 1.6 0.6 33% improvement Comparative Example 3 2.3 1.0 43% improvement Comparative Example 4 1.8 0.6 40% improvement Comparative Example 5 2.6 1.1 50% improvement Comparative Example 6 2.1 0.6 50% improvement Comparative Example 7 2.6 2.1 16% improvement Comparative Example 8 2.5 0.8 56% improvement

As shown in Tables 2 and 3, the adhesive transparent wound coating material prepared using the adhesive transparent wound coating composition containing the corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention (Examples 1 and 2) It can be seen that the improvement effect of interfollicular erythema and follicular erythema pustules is higher than that of Comparative Examples 1 to 7. This is because it was prepared through the optimal mixing ratio including all of the Corydalis extract, pomegranate peel extract, and comfrey leaf extract in Examples 1 and 2, so it forms a physical film on the scalp where the barrier is destroyed, and maintains moisture in the skin environment It is interpreted as a result of showing an improvement by doing so.

In addition, Comparative Example 8 was prepared by exceeding the mixing ratio of the present invention, but including all of the corydalis extract, pomegranate peel extract, and comfrey leaf extract, and in terms of the effect, Example 1 prepared with the mixing ratio of the present invention can be found similar to Therefore, it is determined that it is appropriate to prepare through the mixing ratio of the present invention in consideration of the viscosity and economic feasibility of the composition.

(2) Observation of scalp condition

The adhesive transparent wound covering material (Examples 1 and 2) prepared using the adhesive transparent wound coating composition containing the corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention was applied to the youngest 40 years old and the oldest 60 years old 10 people (5 males, 5 females) were divided into before application and 4 weeks after application, and the condition of the scalp in the front center, crown, left side, right side, and occipital region of the scalp was observed. The results are shown in Figures 1 to 10.

1 to 5 are photos before and after scalp application of the transparent adhesive wound coating material (Example 1) prepared using the adhesive transparent wound coating composition containing the corydalis corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention. 6 to 10 are before scalp application of the adhesive transparent wound coating material (Example 2) prepared using the adhesive transparent wound coating composition containing the corydalis chamomile extract, pomegranate peel extract and comfrey leaf extract according to the present invention. This is the after photo.

As shown in FIGS. 1 to 10, the adhesive transparent wound coating material (Examples 1 and 2) prepared using the adhesive transparent wound coating composition containing the corydalis extract, pomegranate peel extract and comfrey leaf extract according to the present invention It can be seen that after 4 weeks of scalp application, all 10 applied persons showed improvement by forming a physical film on the scalp where the skin barrier was destroyed and maintaining moisture in the skin environment.

Claims (4)

Regarding 100 parts by weight of purified water,
10-20 parts by weight of ethanol, 7-15 parts by weight of beta-glucan, 2-3 parts by weight of Corydalis extract, 3-5 parts by weight of pomegranate peel extract, 1-2 parts by weight of comfrey leaf extract , 7-15 parts by weight of panthenol, 2-5 parts by weight of 1,2-Hexanediol, 1-3 parts by weight of 1,3-butylene glycol ethylhexylglycerin 0.05-0.1 parts by weight, allantoin 0.03-0.1 parts by weight, disodium EDTA 0.01-0.05 parts by weight and ammonium acryloyldimethyltaurate ) An adhesive transparent wound coating composition containing 1 to 3 parts by weight of Corydalis extract, pomegranate peel extract and comfrey leaf extract.
delete According to claim 1,
With respect to 100 parts by weight of the purified water,
Corydalis extract, pomegranate rind extract and comfrey leaf, characterized in that it further comprises 3 to 7 parts by weight of a mixture obtained by mixing equal amounts of algae root extract, licorice extract, cnidium extract, eggplant extract, peony extract and epilobium placerary extract in equal amounts An adhesive transparent wound covering composition containing an extract.
According to claim 1,
The adhesive transparent wound covering composition,
An adhesive transparent wound covering composition containing a coriander extract, a pomegranate peel extract, and a comfrey leaf extract, characterized in that it is formed at a viscosity of 300 to 7,000 cPs and a pH of 4 to 7.

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