KR102605440B1 - Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient - Google Patents
Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient Download PDFInfo
- Publication number
- KR102605440B1 KR102605440B1 KR1020210027696A KR20210027696A KR102605440B1 KR 102605440 B1 KR102605440 B1 KR 102605440B1 KR 1020210027696 A KR1020210027696 A KR 1020210027696A KR 20210027696 A KR20210027696 A KR 20210027696A KR 102605440 B1 KR102605440 B1 KR 102605440B1
- Authority
- KR
- South Korea
- Prior art keywords
- extract
- weight
- cosmetic composition
- mixture
- motherwort
- Prior art date
Links
- 239000000284 extract Substances 0.000 title claims abstract description 98
- 239000000203 mixture Substances 0.000 title claims abstract description 74
- 239000002537 cosmetic Substances 0.000 title claims abstract description 42
- 240000002817 Leonurus sibiricus Species 0.000 title description 2
- 235000002434 Leonurus sibiricus Nutrition 0.000 title description 2
- 239000002075 main ingredient Substances 0.000 title description 2
- 238000005507 spraying Methods 0.000 title 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 claims abstract description 44
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 claims abstract description 44
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 33
- 239000008213 purified water Substances 0.000 claims description 30
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 18
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 18
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 244000192528 Chrysanthemum parthenium Species 0.000 claims description 14
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 13
- 241000186660 Lactobacillus Species 0.000 claims description 13
- 244000303040 Glycyrrhiza glabra Species 0.000 claims description 12
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims description 12
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 12
- 229940039696 lactobacillus Drugs 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 239000002904 solvent Substances 0.000 claims description 12
- 235000007232 Matricaria chamomilla Nutrition 0.000 claims description 10
- 241000219295 Portulaca Species 0.000 claims description 10
- 235000017945 Matricaria Nutrition 0.000 claims description 9
- 240000001341 Reynoutria japonica Species 0.000 claims description 9
- 235000018167 Reynoutria japonica Nutrition 0.000 claims description 9
- 229940059958 centella asiatica extract Drugs 0.000 claims description 9
- 235000020688 green tea extract Nutrition 0.000 claims description 9
- 229940094952 green tea extract Drugs 0.000 claims description 9
- 229940069445 licorice extract Drugs 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 9
- 244000197975 Solidago virgaurea Species 0.000 claims description 8
- 235000000914 Solidago virgaurea Nutrition 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 8
- 239000001331 rosmarinus officinalis leaf Substances 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- RARSHUDCJQSEFJ-UHFFFAOYSA-N p-Hydroxypropiophenone Chemical compound CCC(=O)C1=CC=C(O)C=C1 RARSHUDCJQSEFJ-UHFFFAOYSA-N 0.000 claims description 7
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 claims description 6
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 claims description 6
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 6
- 206010046935 Vaginal odour Diseases 0.000 claims description 6
- 229960000458 allantoin Drugs 0.000 claims description 6
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 6
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 claims description 6
- 229940097941 polyglyceryl-10 laurate Drugs 0.000 claims description 6
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims description 6
- 229940061605 tetrasodium glutamate diacetate Drugs 0.000 claims description 6
- UZVUJVFQFNHRSY-OUTKXMMCSA-J tetrasodium;(2s)-2-[bis(carboxylatomethyl)amino]pentanedioate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CC[C@@H](C([O-])=O)N(CC([O-])=O)CC([O-])=O UZVUJVFQFNHRSY-OUTKXMMCSA-J 0.000 claims description 6
- GAWWVVGZMLGEIW-GNNYBVKZSA-L zinc ricinoleate Chemical compound [Zn+2].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O.CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O GAWWVVGZMLGEIW-GNNYBVKZSA-L 0.000 claims description 6
- 229940100530 zinc ricinoleate Drugs 0.000 claims description 6
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims description 5
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 5
- 239000007864 aqueous solution Substances 0.000 claims description 5
- 229940100524 ethylhexylglycerin Drugs 0.000 claims description 5
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 5
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 5
- 206010056530 Vulvovaginal pruritus Diseases 0.000 claims 5
- 239000004378 Glycyrrhizin Substances 0.000 claims 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 claims 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims 1
- 229960004949 glycyrrhizic acid Drugs 0.000 claims 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims 1
- 235000019410 glycyrrhizin Nutrition 0.000 claims 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims 1
- 241000207925 Leonurus Species 0.000 abstract description 35
- 230000000694 effects Effects 0.000 abstract description 10
- 208000003251 Pruritus Diseases 0.000 abstract description 6
- 230000007803 itching Effects 0.000 abstract description 5
- 206010046914 Vaginal infection Diseases 0.000 description 20
- 201000008100 Vaginitis Diseases 0.000 description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 18
- 239000012071 phase Substances 0.000 description 15
- 208000024891 symptom Diseases 0.000 description 10
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
- 235000011187 glycerol Nutrition 0.000 description 9
- 230000003020 moisturizing effect Effects 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 7
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 5
- 244000042664 Matricaria chamomilla Species 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 4
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 210000001215 vagina Anatomy 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 230000002335 preservative effect Effects 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 206010040880 Skin irritation Diseases 0.000 description 2
- 208000007074 Trichomonas Vaginitis Diseases 0.000 description 2
- 208000025206 Trichomonas vaginitis urogenital infection Diseases 0.000 description 2
- 208000037009 Vaginitis bacterial Diseases 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- -1 and through this Substances 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 239000003595 mist Substances 0.000 description 2
- 230000036556 skin irritation Effects 0.000 description 2
- 231100000475 skin irritation Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
- 208000004746 Atrophic Vaginitis Diseases 0.000 description 1
- 206010003693 Atrophic vulvovaginitis Diseases 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 1
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 1
- 235000017443 Hedysarum boreale Nutrition 0.000 description 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 244000234609 Portulaca oleracea Species 0.000 description 1
- 235000001855 Portulaca oleracea Nutrition 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 244000261559 Smilax china Species 0.000 description 1
- 235000000485 Smilax china Nutrition 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 244000098338 Triticum aestivum Species 0.000 description 1
- 241001106462 Ulmus Species 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000012871 anti-fungal composition Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 230000037365 barrier function of the epidermis Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000003756 cervix mucus Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 229920002674 hyaluronan Polymers 0.000 description 1
- 229960003160 hyaluronic acid Drugs 0.000 description 1
- 230000004968 inflammatory condition Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 230000005722 itchiness Effects 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 201000010808 postmenopausal atrophic vaginitis Diseases 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 229940069774 quince extract Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 235000015639 rosmarinus officinalis Nutrition 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 230000001568 sexual effect Effects 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000002229 urogenital system Anatomy 0.000 description 1
- 206010046901 vaginal discharge Diseases 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cosmetics (AREA)
Abstract
본 발명은 익모초추출물을 포함하는 화장료 조성물에 관한 것으로, 가려움증, 건조함, 냄새 개선 효과가 있다.The present invention relates to a cosmetic composition containing motherwort extract, which has the effect of improving itching, dryness, and odor.
Description
본 발명은 화장료 조성물에 관한 것으로, 익모초추출물을 포함하며 와이존에 뿌리거나 바르는 화장료 조성물에 관한 것이다.The present invention relates to a cosmetic composition, which contains motherwort extract and is sprayed or applied to the Yzone.
질염이란 질의 염증상태를 이르는 말로 감염에 의한 질염, 질점막이 얇아져 생기는 위축성 질염 등이 있다. 질염의 가장 대표적인 증상은 냄새와 질분비물이다. 감염에 의한 질염은 원인에 따라 칸디다 질염, 세균성 질염, 트리코모나스 질염 등으로 나뉜다.Vaginitis refers to an inflammatory condition of the vagina and includes vaginitis caused by infection and atrophic vaginitis caused by thinning of the vaginal mucosa. The most typical symptoms of vaginitis are odor and vaginal discharge. Vaginitis caused by infection is divided into Candida vaginitis, bacterial vaginitis, and Trichomonas vaginitis depending on the cause.
가장 흔한 질염은 칸디다 질염으로 여성의 75%가 평생 적어도 한 번은 경험하며, 반복적으로 감염되기도 한다. 흔한 원인균은 칸디다 알비칸스라는 진균으로 칸디다 질염의 85~90%를 차지한다. 세균성 질염은 정상적인 질 내에서 질을 산성으로 유지하는 락토바실러스라는 유산균이 없어지고 혐기성 세균이 증식하면서 발생한다. 질 내에 존재하는 락토바실러스 유산균은 한 번 없어지고 나면 다시 서식하기 어려워 세균성 질염은 재발하기 쉽다. 트리코모나스 질염은 트리코모나스라는 원충에 의해 감염되는 질염으로, 칸디다 질염, 세균성 질염과 달리 성관계로 전파되는 특징이 있다.The most common vaginitis is Candida vaginitis, which 75% of women experience at least once in their lives, and may be infected repeatedly. The common causative bacteria is a fungus called Candida albicans, which accounts for 85-90% of Candida vaginitis. Bacterial vaginosis occurs when lactobacilli, which keep the vagina acidic, disappear and anaerobic bacteria proliferate in the normal vagina. Once the Lactobacillus acid bacteria present in the vagina disappear, it is difficult to recolonize, and bacterial vaginosis is prone to recurrence. Trichomonas vaginitis is a vaginitis infection caused by a protozoan called Trichomonas, and unlike candida vaginitis and bacterial vaginitis, it has the characteristic of being transmitted through sexual intercourse.
본 발명은 익모초추출물을 이용하여 대표적인 질염 증상인 냄새를 개선하고, 살균 효과가 있는 화장료 조성물을 제공하고자 한다.The present invention aims to provide a cosmetic composition that improves odor, a typical symptom of vaginitis, and has a sterilizing effect by using motherwort extract.
본 발명은 화장료 조성물 전체에 대하여, 익모초추출물 75.00~90.00 중량%, 정제수 1~15 중량%, 1,2-헥산다이올 0.10~5.00 중량%, 알란토인 0.001~0.20 중량%, 다이소듐이디티에이 0.001~0.10 중량%, 다이포타슘글리시리제이트 0.001~0.10 중량%, 소듐하이알루로네이트 0.001~0.1 중량%, 에틸헥실글리세린 0.0001~0.005 중량%, 다이프로필렌글라이콜 0.10~5.00 중량%를 혼합하여 혼합물을 제조하는 단계 (a); 옥틸도데세스-16 0.10~3.50 중량%, 폴리글리세릴-10라우레이트 0.10~3.50 중량%를 혼합한 뒤 상기 단계 (a)의 혼합물에 첨가하는 단계 (b); 클로헥시딘다이글루코네이트 20 %(v/v) 수용액 0.01~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (c); 징크리시놀리에이트 0.01~0.80 중량%, 테트라소듐글루타메이트다이아세테이트 0.01~0.50 중량%, 프로판다이올 0.001~0.10 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(d); 병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 포함하는 혼합추출물 0.001~0.50 중량%, 마치현추출물 0.001~0.5 중량%, 락토바실러스 배양액 0.001~0.1 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(e); 시트릭애씨드 0.001~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (f);를 포함하는 것을 특징으로 하는 화장료 조성물의 제조방법을 제공한다.The present invention contains 75.00-90.00% by weight of motherwort extract, 1-15% by weight of purified water, 0.10-5.00% by weight of 1,2-hexanediol, 0.001-0.20% by weight of allantoin, and 0.001% of disodium EDTA, based on the entire cosmetic composition. Mix ~0.10% by weight, dipotassium glycyrrhizate 0.001~0.10% by weight, sodium hyaluronate 0.001~0.1% by weight, ethylhexylglycerin 0.0001~0.005% by weight, and dipropylene glycol 0.10~5.00% by weight. Step (a) of preparing the mixture; Step (b) of mixing 0.10 to 3.50 wt% of octyldodeceth-16 and 0.10 to 3.50 wt% of polyglyceryl-10 laurate and adding them to the mixture of step (a); Step (c) of adding 0.01 to 0.50% by weight of a 20% (v/v) aqueous solution of chlorhexidine digluconate to the mixture of step (a); Step (d) adding 0.01 to 0.80 wt% of zinc ricinoleate, 0.01 to 0.50 wt% of tetrasodium glutamate diacetate, and 0.001 to 0.10 wt% of propanediol to the mixture of step (a); Mixed extract containing centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract 0.001~0.50% by weight, portulaca extract 0.001~0.5% by weight, Lactobacillus culture medium 0.001~ (e) adding 0.1% by weight to the mixture of step (a); It provides a method for producing a cosmetic composition comprising the step (f) of adding 0.001 to 0.50% by weight of citric acid to the mixture of step (a).
본 발명에 있어서, 상기 익모초추출물은, 바람직하게는 익모초추출물을 정제수 및 1,2-헥산다이올과 혼합하여 액상화 한 것이 좋다.In the present invention, the motherwort extract is preferably liquefied by mixing the motherwort extract with purified water and 1,2-hexanediol.
본 발명에 있어서, 상기 익모초추출물은, 바람직하게는 추출용매로 정제수를 이용하여 60~80℃에서 1~3시간 추출한 것이 좋다.In the present invention, the motherwort extract is preferably extracted at 60-80°C for 1-3 hours using purified water as an extraction solvent.
본 발명에 있어서, 상기 단계 (e)의 혼합추출물은, 바람직하게는 병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 정제수와 부틸렌글라이콜에 용해시킨 것이 좋다.In the present invention, the mixed extract of step (e) is preferably composed of centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract with purified water and butylene glycol. It is better to dissolve it in chol.
또한, 본 발명은 상기의 제조방법에 의해 제조된 화장료 조성물을 제공한다.Additionally, the present invention provides a cosmetic composition prepared by the above production method.
본 발명에 있어서, 상기 화장료 조성물은, 바람직하게는 질 냄새 제거용인 것일 수 있다.In the present invention, the cosmetic composition may be preferably used to remove vaginal odor.
본 발명은 익모초추출물을 이용하여 대표적인 질염 증상인 냄새를 개선하고, 살균 효과가 있는 화장료 조성물을 제공한다.The present invention provides a cosmetic composition that improves odor, a typical symptom of vaginitis, and has a sterilizing effect using motherwort extract.
본 발명은 사용 후 가려움증, 건조함, 냄새를 개선할 수 있는 화장료 조성물을 제공한다.The present invention provides a cosmetic composition that can improve itching, dryness, and odor after use.
본 발명은 익모초추출물을 주 원료로 하는 여성의 와이존에 뿌리거나 바르는 화장료 조성물을 제공한다.The present invention provides a cosmetic composition that can be sprayed or applied to a woman's Y-zone, which contains motherwort extract as the main ingredient.
익모초(Leonurus Sibiricus)는 꿀풀과의 두해살이풀로 임신과 산후에 유발되는 여러 병을 잘 낫게 한다고 알려져 있으며, 시력개선, 혈액순환 개선 등의 효능이 있다고 알려져 있다. Motherwort ( Leonurus Sibiricus ) is a biennial plant of the Lamiaceae family and is known to cure various diseases caused during pregnancy and postpartum. It is also known to have effects such as improving eyesight and improving blood circulation.
본 발명은 익모초추출물을 정제수 및 1,2-헥산다이올을 포함하는 용액으로 제조하여 액상으로 만들어 이용하였으며, 이를 통해 제형 안정성을 확보할 수 있었다. 바람직하게는 익모초추출물 0.90~1.10 중량%, 정제수 96.00~98.00 중량%, 1,2-헥산다이올 1.80~2.20 중량%로 구성되는 것이 좋다. In the present invention, motherwort extract was prepared in a liquid form using a solution containing purified water and 1,2-hexanediol, and through this, formulation stability was secured. Preferably, it is composed of 0.90-1.10% by weight of motherwort extract, 96.00-98.00% by weight of purified water, and 1.80-2.20% by weight of 1,2-hexanediol.
본 발명은 화장료 조성물 전체에 대하여, 익모초추출물 75.00~90.00 중량%, 정제수 1~15 중량%, 1,2-헥산다이올 0.10~5.00 중량%, 알란토인 0.001~0.20 중량%, 다이소듐이디티에이 0.001~0.10 중량%, 다이포타슘글리시리제이트 0.001~0.10 중량%, 소듐하이알루로네이트 0.001~0.1 중량%, 에틸헥실글리세린 0.0001~0.005 중량%, 다이프로필렌글라이콜 0.10~5.00 중량%를 혼합하여 혼합물을 제조하는 단계 (a); 옥틸도데세스-16 0.10~3.50 중량%, 폴리글리세릴-10라우레이트 0.10~3.50 중량%를 혼합한 뒤 상기 단계 (a)의 혼합물에 첨가하는 단계 (b); 클로헥시딘다이글루코네이트 20 %(v/v) 수용액 0.01~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (c); 징크리시놀리에이트 0.01~0.80 중량%, 테트라소듐글루타메이트다이아세테이트 0.01~0.50 중량%, 프로판다이올 0.001~0.10 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(d); 병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 포함하는 혼합추출물 0.001~0.50 중량%, 마치현추출물 0.001~0.5 중량%, 락토바실러스 배양액 0.001~0.1 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(e); 시트릭애씨드 0.001~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (f);를 포함하는 것을 특징으로 하는 화장료 조성물의 제조방법을 제공한다.The present invention contains 75.00-90.00% by weight of motherwort extract, 1-15% by weight of purified water, 0.10-5.00% by weight of 1,2-hexanediol, 0.001-0.20% by weight of allantoin, and 0.001% of disodium EDTA, based on the entire cosmetic composition. Mix ~0.10% by weight, dipotassium glycyrrhizate 0.001~0.10% by weight, sodium hyaluronate 0.001~0.1% by weight, ethylhexylglycerin 0.0001~0.005% by weight, and dipropylene glycol 0.10~5.00% by weight. Step (a) of preparing the mixture; Step (b) of mixing 0.10 to 3.50 wt% of octyldodeceth-16 and 0.10 to 3.50 wt% of polyglyceryl-10 laurate and adding them to the mixture of step (a); Step (c) of adding 0.01 to 0.50% by weight of a 20% (v/v) aqueous solution of chlorhexidine digluconate to the mixture of step (a); Step (d) adding 0.01 to 0.80 wt% of zinc ricinoleate, 0.01 to 0.50 wt% of tetrasodium glutamate diacetate, and 0.001 to 0.10 wt% of propanediol to the mixture of step (a); Mixed extract containing centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract 0.001~0.50% by weight, portulaca extract 0.001~0.5% by weight, Lactobacillus culture medium 0.001~ (e) adding 0.1% by weight to the mixture of step (a); It provides a method for producing a cosmetic composition comprising the step (f) of adding 0.001 to 0.50% by weight of citric acid to the mixture of step (a).
본 발명에 있어서, 상기 익모초추출물은 당업계에 공지된 통상적인 용매를 사용하여 제조될 수 있으며, 일 예로 물, 탄소수 1-4의 무수 또는 함수 저급 알코올, 프로필렌글리콜, 부틸렌글리콜, 글리세린 및 이들의 혼합물로 구성된 군으로부터 선택되는 추출용매를 이용하여 제조할 수 있으나, 바람직하게는 정제수 또는 다가알코올을 이용하는 것이 좋다. 더욱 바람직하게는 추출용매로 정제수를 이용하여 60~80℃에서 1~3시간 추출한 것이 좋다.In the present invention, the motherwort extract can be prepared using common solvents known in the art, examples of which include water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, and these. It can be prepared using an extraction solvent selected from the group consisting of a mixture of, but preferably purified water or polyhydric alcohol is used. More preferably, extraction is performed at 60 to 80°C for 1 to 3 hours using purified water as an extraction solvent.
본 발명에 있어서, 상기 1,2-헥산다이올(1,2-Hexanediol)은 독성 없는 방부제 기능을 가진 성분으로 화장료 조성물에 다양하게 사용된다.In the present invention, 1,2-hexanediol is a non-toxic preservative and is used in various cosmetic compositions.
본 발명에 있어서, 상기 알란토인(Allantoin)은 밀의 싹 등에서 추출한 천연물질 또는 합성물질을 이용할 수 있으며, 보습, 상처 치유, 자극 완화 등의 효과가 있다고 알려져 있다.In the present invention, the allantoin can be a natural substance or a synthetic substance extracted from wheat sprouts, etc., and is known to have effects such as moisturizing, wound healing, and irritation relief.
본 발명에 있어서, 상기 다이소듐이디티에이(Disodium EDTA)는 화장품의 금속이온을 봉쇄 함으로써 산패 방지, 향료 화합물 보호 등의 효과가 있는 안정제 성분이다.In the present invention, Disodium EDTA is a stabilizer ingredient that is effective in preventing rancidity and protecting fragrance compounds by blocking metal ions in cosmetics.
본 발명에 있어서, 상기 다이포타슘글리시리제이트(Dipotassium Glycyrrhizate)는 감초뿌리에서 추출한 천연성분으로, 항염효과가 있어 민감성 피부에 도움을 주며, 피지조절, 피부 표피장벽의 손상 회복 등의 효과가 있다고 알려져 있다.In the present invention, Dipotassium Glycyrrhizate is a natural ingredient extracted from licorice root, has an anti-inflammatory effect, helps sensitive skin, and has effects such as sebum control and recovery of damage to the skin epidermal barrier. It is known.
본 발명에 있어서, 상기 소듐하이알루로네이트(Sodium Hyaluronate)는 히알루론산이라고 불리기도 하며, 천연 보습인자로 주변의 수분을 끌어당기는 효과가 있다.In the present invention, the sodium hyaluronate is also called hyaluronic acid and is a natural moisturizing factor that has the effect of attracting moisture from the surrounding area.
본 발명에 있어서, 상기 에틸헥실글리세린(Ethylhexylglycerin)은 화장료 조성물에 첨가 시 끈적임을 개선할 수 있으며, 방부 성분의 효능을 향상시키며, 보습 효과가 있다.In the present invention, ethylhexylglycerin can improve stickiness when added to a cosmetic composition, improves the effectiveness of preservative ingredients, and has a moisturizing effect.
본 발명에 있어서, 상기 다이프로필렌글라이콜(Dipropylene Glycol)은 보습제로 사용된다.In the present invention, Dipropylene Glycol is used as a moisturizing agent.
본 발명에 있어서, 상기 옥틸도데세스-16(Octyldodeceth-16)는 촉감이 좋고 특이 취를 가진 백색의 페이스트로 가용화제 역할을 수행하여 화장품의 불안정안 상태를 안정화 시키는 역할을 한다.In the present invention, Octyldodeceth-16 is a white paste with a good feel and a specific odor, and serves as a solubilizer to stabilize the unstable state of cosmetics.
본 발명에 있어서, 상기 폴리글리세릴-10라우레이트(Polyglyceryl-10 Laurate)는 가용화제로 구조상 피부에 닿는 부분이 수상으로 구성되어 가볍고 끈적이지 않는 사용감을 주는 효과가 있다.In the present invention, the polyglyceryl-10 laurate is a solubilizer, and the part that touches the skin is structurally composed of an aqueous phase, so it has the effect of providing a light and non-sticky feeling.
본 발명의 향료는 TNC사의 TNCR-205551 또는 TNCR-305545를 이용할 수 있다. 향료를 이용하지 않을 경우 정제수를 해당 중량% 만큼 증량하여 제조하는 것이 좋다.The fragrance of the present invention can be used as TNCR-205551 or TNCR-305545 from TNC. If flavoring is not used, it is recommended to manufacture it by increasing the amount of purified water by the corresponding weight%.
본 발명에 있어서, 상기 클로헥시딘다이글루코네이트(Chlorhexidine Digluconate)는 살균제, 소독제, 방부제 등으로 이용하는 성분이나 피부 자극을 유발할 우려가 있어, 씻어내는 화장료 조성물에는 전체 중량에 대하여 0.1 중량% 이하로 사용하는 것이 좋다고 알려져 있다. 본 발명은 화장료 조성물 전체에 대하여 클로헥시딘다이글루코네이트 0.048 중량%, 정제수 0.192 중량%로 이루어진 클로헥시딘다이글루코네이트 20 %(v/v) 수용액을 사용하였으며 이에 따라 피부 자극을 더욱 완화할 수 있었다.In the present invention, Chlorhexidine Digluconate is an ingredient used as a disinfectant, disinfectant, preservative, etc., but has the risk of causing skin irritation, so it should be used in washable cosmetic compositions at 0.1% by weight or less based on the total weight. It is known to be good to use. In the present invention, a 20% (v/v) aqueous solution of chlorhexidine digluconate consisting of 0.048% by weight of chlorhexidine digluconate and 0.192% by weight of purified water was used for the entire cosmetic composition, thereby further alleviating skin irritation. Could.
본 발명에 있어서, 상기 징크리시놀리에이트(Zinc Ricinoleate)는 냄새 분자와 결합하여 냄새 분자를 비활성화 시키는 효과가 있다.In the present invention, the zinc ricinoleate has the effect of deactivating odor molecules by binding to them.
본 발명에 있어서, 상기 테트라소듐글루타메이트다이아세테이트(Tetrasodium Glutamate Diacetate)는 금속이온의 생성을 봉쇄하는 역할을 한다.In the present invention, Tetrasodium Glutamate Diacetate serves to block the production of metal ions.
본 발명에 있어서, 상기 프로판다이올(Propanediol) 옥수수 유래의 천연 성분으로 점도 조절, 유화 안정, 보습 등의 효과가 있다.In the present invention, propanediol, a natural ingredient derived from corn, has effects such as viscosity control, emulsion stabilization, and moisturizing.
본 발명은 익모초추출물 외에 병풀추출물(Centella Asiatica Extract), 호장근추출물(Polygonum Cuspidatum Root Extract), 황금추출물(Scutellaria Baicalensis Root Extract), 녹차추출물(Camellia Sinensis Leaf Extract), 스페인감초추출물(Glycyrrhiza Glabra (Licorice) Root Extract), 마트리카리아꽃추출물(Chamomilla Recutita (Matricaria) Flower Extract), 로즈마리잎추출물(Rosmarinus Officinalis (Rosemary) Leaf Extract), 마치현추출물(Portulaca Oleracea Extract)을 사용하는데, 이를 통해 한층 증진된 가려움, 건조함, 냄새 개선 등의 질염 증상 개선능을 확인할 수 있었다. In addition to motherwort extract, the present invention includes Centella Asiatica Extract, Polygonum Cuspidatum Root Extract, Scutellaria Baicalensis Root Extract, Green Tea Extract ( Camellia Sinensis Leaf Extract), and Spanish Licorice Extract ( Glycyrrhiza Glabra (Licorice) ) Root Extract, Chamomilla Recutita (Matricaria) Flower Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, and Portulaca Oleracea Extract are used, which further improves itchiness. , the ability to improve vaginitis symptoms such as dryness and odor improvement was confirmed.
본 발명에 있어서, 상기 단계 (e)의 혼합추출물은, 병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 정제수와 부틸렌글라이콜에 용해시킨 것을 사용하는 것이 좋으며, 일 예로 상품명 'MultiEX BSASM Plus' (바이오스펙스럼 社)을 사용할 수 있다. 또한 각 추출물은 당업계에 공지된 통상적인 용매를 사용하여 제조될 수 있으며, 일 예로 물, 탄소수 1-4의 무수 또는 함수 저급 알코올, 프로필렌글리콜, 부틸렌글리콜, 글리세린 및 이들의 혼합물로 구성된 군으로부터 선택되는 추출용매를 이용하여 제조할 수 있다.In the present invention, the mixed extract of step (e) includes centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract dissolved in purified water and butylene glycol. It is recommended to use what is ordered, and as an example, you can use the product name 'MultiEX BSASM Plus' (Biosspectrum Co., Ltd.). In addition, each extract can be prepared using a common solvent known in the art, for example, a group consisting of water, anhydrous or hydrous lower alcohol with 1-4 carbon atoms, propylene glycol, butylene glycol, glycerin, and mixtures thereof. It can be prepared using an extraction solvent selected from.
상기 부틸렌글라이콜(Butylene Glycol)은 용제로 사용되며, 각 성분을 용해시키는 역할을 한다. 또한 수분을 끌어당기는 기능이 있어 보습효과를 주기도 한다. The butylene glycol is used as a solvent and serves to dissolve each component. It also has the function of attracting moisture, providing a moisturizing effect.
본 발명에 있어서, 상기 단계 (e)의 락토바실러스 배양액은, 락토바실러스를 대량으로 증식시킨 것을 말한다. 본 발명의 락토바실러스 배양액은, 정제수, 글리세린, 부틸렌글라이콜, 1,2-헥산다이올과 혼합하여 이용하는 것이 좋은데, 바람직하게는, 락토바실러스 배양액 0.10~2.00 중량%, 정제수 80.00~90.00 중량%, 글리세린 5~15 중량%, 부틸렌글라이콜 0.1~2 중량%, 1,2-헥산다이올 0.1~4 중량%를 혼합하는 것이 좋다. 상기 범위에 따라 혼합될 경우 본 발명의 화장료 조성물의 제형을 안정적으로 유지할 수 있다.In the present invention, the Lactobacillus culture medium in step (e) refers to a product in which Lactobacillus is grown in large quantities. The Lactobacillus culture medium of the present invention is preferably used by mixing with purified water, glycerin, butylene glycol, and 1,2-hexanediol, preferably 0.10 to 2.00% by weight of Lactobacillus culture medium and 80.00 to 90.00% by weight of purified water. , it is recommended to mix 5 to 15% by weight of glycerin, 0.1 to 2% by weight of butylene glycol, and 0.1 to 4% by weight of 1,2-hexanediol. When mixed according to the above range, the formulation of the cosmetic composition of the present invention can be stably maintained.
본 발명에 있어서, 상기 단계 (e)의 마치현 추출물은, 상기 익모초 추출물과 동일하게 제조될 수 있으며, 당업계에 공지된 통상적인 용매를 사용하여 제조될 수도 있다. 일 예로 물, 탄소수 1-4의 무수 또는 함수 저급 알코올, 프로필렌글리콜, 부틸렌글리콜, 글리세린 및 이들의 혼합물로 구성된 군으로부터 선택되는 추출용매를 이용하여 제조할 수 있다.In the present invention, the Portulaca vulgaris extract of step (e) may be prepared in the same manner as the motherwort extract, and may also be prepared using a conventional solvent known in the art. For example, it can be prepared using an extraction solvent selected from the group consisting of water, anhydrous or hydrous lower alcohols having 1 to 4 carbon atoms, propylene glycol, butylene glycol, glycerin, and mixtures thereof.
본 발명의 화장료 조성물은 바람직하게는 액상 타입의 스프레이, 즉 미스트(mist) 제형인 것이 좋다. 또한, 본 발명의 화장료 조성물은 당 업계에서 미스트 제조시 통상적으로 사용하는 보조제를 첨가하여 제조할 수 있다.The cosmetic composition of the present invention is preferably a liquid type spray, that is, a mist formulation. Additionally, the cosmetic composition of the present invention can be prepared by adding auxiliaries commonly used in the production of mist in the art.
본 발명의 화장료 조성물의 바람직한 사용량은 당업자에 의해 적절하게 선택될 수 있다. The preferred usage amount of the cosmetic composition of the present invention can be appropriately selected by a person skilled in the art.
본 발명의 화장료 조성물은 하나 이상의 여성 비뇨생식기계 관련 질병병 예방 또는 치료 활성을 나타내는 물질과 함께 투여될 수 있다.The cosmetic composition of the present invention can be administered together with one or more substances showing activity in preventing or treating diseases related to the female genitourinary system.
이하, 본 발명의 내용을 하기 실시예 및 실험예를 통해 더욱 상세히 설명하고자 한다. 다만, 본 발명의 권리범위가 하기 실시예에만 한정되는 것은 아니고, 그와 등가의 기술적 사상의 변형까지를 포함한다.Hereinafter, the contents of the present invention will be described in more detail through the following examples and experimental examples. However, the scope of the present invention is not limited to the following examples, but also includes modifications of the technical idea equivalent thereto.
[실시예 1 : 익모초추출물의 제조][Example 1: Preparation of Motherwort extract]
건조된 익모초 100 g에 1,000 ml의 정제수를 가하고 80 ℃에서 2시간 열수추출한 뒤, 3 ㎛, 1 ㎛, 0.45 ㎛ 순서로 여과하고 이를 농축하였다. 110 ℃에서 2시간 건조하여 완전건조시킨 뒤 건조중량을 확인한 결과를 아래 표 1에 나타내었다. 1,000 ml of purified water was added to 100 g of dried motherwort, subjected to hot water extraction at 80°C for 2 hours, filtered through 3 ㎛, 1 ㎛, and 0.45 ㎛ in that order, and then concentrated. After drying at 110°C for 2 hours to completely dry, the dry weight was checked and the results are shown in Table 1 below.
익모초추출물의 제조를 3회 반복하여 익모초추출물의 수득량을 확인한 결과, 평균 18.4 g/L 수득되는 점을 확인하였다.As a result of confirming the yield of Motherwort extract by repeating the preparation of Motherwort extract three times, it was confirmed that an average of 18.4 g/L was obtained.
[실시예 2 : 익모초추출물을 포함하는 화장료 조성물 제조][Example 2: Preparation of a cosmetic composition containing motherwort extract]
본 실시예에서는 상기 실시예 1의 익모초추출물을 포함하는 화장료 조성물을 제조하였다. 각 성분의 중량%는 익모초추출물을 포함하는 화장료 조성물 전체 중량에 대한 비율로 나타내었다.In this example, a cosmetic composition containing the motherwort extract of Example 1 was prepared. The weight percent of each ingredient was expressed as a ratio to the total weight of the cosmetic composition containing motherwort extract.
A 상의 익모초추출물은 정제수 및 1,2-헥산다이올을 이용하여 액상화하였다(익모초추출물 1.00 중량%, 정제수 97.00 중량%, 1,2-헥산다이올 2.00 중량% 혼합한 액상화된 익모초추출물).The motherwort extract in phase A was liquefied using purified water and 1,2-hexanediol (liquefied motherwort extract mixed with 1.00% by weight of motherwort extract, 97.00% by weight of purified water, and 2.00% by weight of 1,2-hexanediol).
액상화된 익모초추출물 80.06 중량%, 정제수 8.4488 중량%, 1,2-헥산다이올 2.02 중량%, 알란토인 0.10 중량%, 다이소듐이디티에이 0.02 중량%, 다이포타슘글리시리제이트 0.05 중량%, 소듐하이알루로네이트 0.01 중량%, 에틸헥실글리세린 0.0012 중량%, 다이프로필렌글라이콜 2.50 중량%를 혼합하여 A 상을 제조하였다.Liquefied motherwort extract 80.06% by weight, purified water 8.4488% by weight, 1,2-hexanediol 2.02% by weight, allantoin 0.10% by weight, disodium EDTA 0.02% by weight, dipotassium glycyrrhizate 0.05% by weight, sodium high Phase A was prepared by mixing 0.01% by weight of aluronate, 0.0012% by weight of ethylhexylglycerin, and 2.50% by weight of dipropylene glycol.
B 상으로 옥틸도데세스-16 1.50 중량%, 폴리글리세릴-10라우레이트 1.50 중량%, 향료 1.2 중량%를 혼합하여 용해시킨 후 A 상과 혼합하였다. 향료는 TNC사의 TNCR-205551을 이용하였다. 향료를 이용하지 않을 경우 A 상의 정제수를 해당 중량%만큼 증량하여 제조하는 것이 좋다.In phase B, 1.50% by weight of octyldodeceth-16, 1.50% by weight of polyglyceryl-10 laurate, and 1.2% by weight of fragrance were mixed and dissolved and then mixed with phase A. The fragrance used was TNC's TNCR-205551. If flavoring is not used, it is recommended to manufacture it by increasing the amount of purified water in phase A by the corresponding weight%.
C 상, D 상, E 상, F 상은 각각 별도의 용기에 계량하였다. C 상은 클로헥시딘다이글루코네이트 20 %(v/v) 수용액을 0.24 중량%을 사용하였다. D 상은 정제수 1.24 중량%, 징크리시놀리에이트 0.42 중량%, 테트라소듐글루타메이트다이아세테이트 0.26 중량%, 프로판다이올 0.08 중량%를 혼합하여 사용하였다. E 상의 병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물은 바이오스펙스럼 社의 'MultiEX BSASM Plus' 제품을 사용하였으며, 0.1 중량% 사용하였다. E 상의 마치현추출물은 마치현을 실시예 1과 동일한 방법으로 추출한 것을 사용하였으며, 마치현추출물을 정제수, 글리세린, 부틸렌글라이콜, 1,2-헥산다이올과 혼합한 것을 0.1 중량% 사용하였다(마치현추출물 0.001 중량%, 정제수 0.086 중량%, 글리세린 0.01 중량%, 부틸렌글라이콜 0.001 중량%, 1,2-헥산다이올 0.002 중량%를 혼합한 마치현추출물혼합물).Phases C, D, E, and F were each weighed in separate containers. Phase C used 0.24% by weight of 20% (v/v) aqueous solution of chlorhexidine digluconate. Phase D was used by mixing 1.24% by weight of purified water, 0.42% by weight of zinc ricinoleate, 0.26% by weight of tetrasodium glutamate diacetate, and 0.08% by weight of propanediol. For the Centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, Matricaria flower extract, and rosemary leaf extract in phase E, 'MultiEX BSASM Plus' from BioSpecsrum was used, and was used at 0.1% by weight. Portulaca fragrant extract in phase E was used by extracting Portulaca vulgaris in the same manner as in Example 1, and 0.1% by weight of Portulaca vulgaris extract mixed with purified water, glycerin, butylene glycol, and 1,2-hexanediol was used (Portulaca vulgaris extract Portulaca fragrant extract mixture containing 0.001% by weight, 0.086% by weight of purified water, 0.01% by weight of glycerin, 0.001% by weight of butylene glycol, and 0.002% by weight of 1,2-hexanediol).
E 상의 락토바실러스 배양액은 제형 안정성을 위해 정제수, 글리세린, 부틸렌글라이콜, 1,2-헥산다이올을 혼합한 것을 0.05 중량% 사용하였다(락토바실러스 배양액 1.00 중량%, 정제수 86.00 중량%, 글리세린 10.00 중량%, 부틸렌글라이콜 1.00 중량%, 1,2-헥산다이올 2.00 중량% 혼합한 락토바실러스 배양액 혼합물). F 상은 시트릭애씨드 0.1 중량%를 사용하였다. The Lactobacillus culture medium in phase E was a mixture of purified water, glycerin, butylene glycol, and 1,2-hexanediol at 0.05% by weight for formulation stability (Lactobacillus culture medium 1.00% by weight, purified water 86.00% by weight, glycerin 10.00%). Weight%, Lactobacillus culture mixture mixed with 1.00% by weight of butylene glycol and 2.00% by weight of 1,2-hexanediol). Phase F used 0.1% by weight of citric acid.
C 상, D 상, E 상, F 상을 순서대로 A 상에 교반 용해 하여 익모초추출물을 포함하는 화장료 조성물을 제조하였다.Phase C, D, E, and F were sequentially stirred and dissolved in phase A to prepare a cosmetic composition containing motherwort extract.
[실시예 3 - 9 : 익모초추출물의 함량을 달리하여 화장료 조성물 제조][Example 3-9: Preparation of cosmetic composition by varying the content of motherwort extract]
액상화된 익모초추출물의 함량을 달리하여 상기 실시예 2와 동일하게 화장료 조성물을 제조하였다. 액상화된 익모초추출물의 감소량은 A 상의 정제수 함량을 증량하여 제조하였다.A cosmetic composition was prepared in the same manner as in Example 2, varying the content of the liquefied motherwort extract. The reduced amount of liquefied motherwort extract was prepared by increasing the purified water content of phase A.
3Example
3
4Example
4
5Example
5
6Example
6
7Example
7
8Example
8
9Example
9
익모초
추출물liquefied
motherwort
extract
[실험예 1 : 익모초추출물을 포함하는 화장료 조성물의 사용감 평가][Experimental Example 1: Evaluation of the feeling of use of a cosmetic composition containing motherwort extract]
본 실험에서는 익모초추출물을 포함하는 화장료 조성물의 사용감을 평가하고자 하였다. 20~40대 여성 25명을 임의로 선발하여 본 발명의 익모초추출물을 포함하는 화장료 조성물 사용 후 가려움이 개선되는 정도, 보습 효과에 대하여 5점 척도법(1:매우 나쁘다, 5:매우 좋다)을 사용하여 사용감 평가를 수행하였다.In this experiment, we attempted to evaluate the feeling of use of a cosmetic composition containing motherwort extract. Twenty-five women in their 20s to 40s were randomly selected and evaluated for the degree to which itching was improved and the moisturizing effect after using the cosmetic composition containing the motherwort extract of the present invention using a 5-point scale (1: very bad, 5: very good). A usability evaluation was performed.
2Example
2
3Example
3
4Example
4
5Example
5
6Example
6
7Example
7
8Example
8
9Example
9
개선itch
improvement
개선smell
improvement
선호도Overall
preference
상기 표 4에서 보듯이, 본 발명의 익모초추출물의 함량에 따라 가려움 개선, 보습감, 냄새 개선 등에 차이를 보이는 점을 확인하였다. 특히, 실시예 3, 4, 5는 제형이 비교적 불안정한 점이 관찰되었는데, 이에 따라 화장료 조성물의 효능이 전달되지 못한 것으로 나타났다.As shown in Table 4 above, it was confirmed that there were differences in itching, moisturizing, and odor improvement depending on the content of the motherwort extract of the present invention. In particular, in Examples 3, 4, and 5, it was observed that the formulation was relatively unstable, and as a result, the efficacy of the cosmetic composition was not delivered.
[실험예 2 : 익모초추출물을 포함하는 화장료 조성물의 질염 증상 완화 효과][Experimental Example 2: Effect of relieving vaginitis symptoms of a cosmetic composition containing motherwort extract]
본 실험에서는 상기 실험예 1에 의해 사용감이 가장 좋은 것으로 나타난 실시예 2를 이용하여 질염 증상(가려움, 건조함, 냄새 등) 완화 정도를 평가하였다. 질염 증상을 겪고있는 여성 13명을 임의로 선정하여 주 3회 사용 시 질염 증상 완화 정도를 5점 척도법(1:매우 나쁘다, 5:매우 좋다)으로 평가하였다.In this experiment, the degree of relief of vaginitis symptoms (itching, dryness, odor, etc.) was evaluated using Example 2, which was shown to have the best feeling of use according to Experimental Example 1. Thirteen women suffering from vaginitis symptoms were randomly selected and the degree of relief from vaginitis symptoms when used three times a week was evaluated on a 5-point scale (1: very bad, 5: very good).
상기 표 5에서 보듯이, 본 발명의 익모초추출물을 포함하는 화장료 조성물은 1회 사용시에도 질염 증상을 완화하는 효과를 보였으며 2회 사용시부터는 질염 증상이 효과적으로 완화되는 점을 확인하였다.As shown in Table 5, it was confirmed that the cosmetic composition containing the motherwort extract of the present invention was effective in alleviating vaginitis symptoms even when used once, and that vaginitis symptoms were effectively alleviated from the second use.
Claims (6)
익모초추출물 75.00~90.00 중량%, 정제수 1~15 중량%, 1,2-헥산다이올 0.10~5.00 중량%, 알란토인 0.001~0.20 중량%, 다이소듐이디티에이 0.001~0.10 중량%, 다이포타슘글리시리제이트 0.001~0.10 중량%, 소듐하이알루로네이트 0.001~0.1 중량%, 에틸헥실글리세린 0.0001~0.005 중량%, 다이프로필렌글라이콜 0.10~5.00 중량%를 혼합하여 혼합물을 제조하는 단계 (a);
옥틸도데세스-16 0.10~3.50 중량%, 폴리글리세릴-10라우레이트 0.10~3.50 중량%를 혼합한 뒤 상기 단계 (a)의 혼합물에 첨가하는 단계 (b);
클로헥시딘다이글루코네이트 20 %(v/v) 수용액 0.01~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (c);
징크리시놀리에이트 0.01~0.80 중량%, 테트라소듐글루타메이트다이아세테이트 0.01~0.50 중량%, 프로판다이올 0.001~0.10 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(d);
병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 포함하는 혼합추출물 0.001~0.50 중량%, 마치현추출물 0.001~0.5 중량%, 락토바실러스 배양액 0.001~0.1 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계(e);
시트릭애씨드 0.001~0.50 중량%를 상기 단계 (a)의 혼합물에 첨가하는 단계 (f);를 포함하는 것을 특징으로 하는 질 가려움증 및 질 냄새 제거용 화장료 조성물의 제조방법.
Regarding the entire cosmetic composition,
Motherwort extract 75.00~90.00% by weight, purified water 1~15% by weight, 1,2-hexanediol 0.10~5.00% by weight, allantoin 0.001~0.20% by weight, disodium EDTA 0.001~0.10% by weight, dipotassium glycyrrhizin. Step (a) of preparing a mixture by mixing 0.001 to 0.10% by weight of zate, 0.001 to 0.1% by weight of sodium hyaluronate, 0.0001 to 0.005% by weight of ethylhexylglycerin, and 0.10 to 5.00% by weight of dipropylene glycol;
Step (b) of mixing 0.10 to 3.50 wt% of octyldodeceth-16 and 0.10 to 3.50 wt% of polyglyceryl-10 laurate and adding them to the mixture of step (a);
Step (c) of adding 0.01 to 0.50% by weight of a 20% (v/v) aqueous solution of chlorhexidine digluconate to the mixture of step (a);
Step (d) adding 0.01 to 0.80 wt% of zinc ricinoleate, 0.01 to 0.50 wt% of tetrasodium glutamate diacetate, and 0.001 to 0.10 wt% of propanediol to the mixture of step (a);
Mixed extract containing centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract 0.001~0.50% by weight, portulaca extract 0.001~0.5% by weight, Lactobacillus culture medium 0.001~ (e) adding 0.1% by weight to the mixture of step (a);
A method for producing a cosmetic composition for removing vaginal itching and vaginal odor, comprising the step (f) of adding 0.001 to 0.50% by weight of citric acid to the mixture of step (a).
상기 익모초추출물은,
익모초추출물을 정제수 및 1,2-헥산다이올과 혼합하여 액상화 한 것을 특징으로 하는 질 가려움증 및 질 냄새 제거용 화장료 조성물의 제조방법.
According to paragraph 1,
The motherwort extract,
A method for producing a cosmetic composition for removing vaginal itching and vaginal odor, characterized in that motherwort extract is liquefied by mixing it with purified water and 1,2-hexanediol.
상기 익모초추출물은,
추출용매로 정제수를 이용하여 60~80℃에서 1~3시간 추출한 것을 특징으로 하는 질 가려움증 및 질 냄새 제거용 화장료 조성물의 제조방법.
According to paragraph 2,
The motherwort extract,
A method for producing a cosmetic composition for removing vaginal itching and vaginal odor, characterized in that it is extracted at 60-80°C for 1-3 hours using purified water as an extraction solvent.
상기 단계 (e)의 혼합추출물은,
병풀추출물, 호장근추출물, 황금추출물, 녹차추출물, 스페인감초추출물, 마트리카리아꽃추출물, 로즈마리잎추출물을 정제수와 부틸렌글라이콜에 용해시킨 것을 특징으로 하는 질 가려움증 및 질 냄새 제거용 화장료 조성물의 제조방법.
According to paragraph 1,
The mixed extract of step (e) is,
A cosmetic composition for removing vaginal itching and vaginal odor, comprising centella asiatica extract, Japanese knotweed extract, goldenrod extract, green tea extract, Spanish licorice extract, matricaria flower extract, and rosemary leaf extract dissolved in purified water and butylene glycol. Manufacturing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210027696A KR102605440B1 (en) | 2021-03-02 | 2021-03-02 | Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020210027696A KR102605440B1 (en) | 2021-03-02 | 2021-03-02 | Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20220124027A KR20220124027A (en) | 2022-09-13 |
| KR102605440B1 true KR102605440B1 (en) | 2023-11-23 |
Family
ID=83286654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020210027696A KR102605440B1 (en) | 2021-03-02 | 2021-03-02 | Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR102605440B1 (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102165565B1 (en) | 2019-07-22 | 2020-10-14 | 주식회사 오퍼스아시아 | Cosmetic composition with excellent blemish and blemishes |
| KR102165567B1 (en) | 2019-07-22 | 2020-10-14 | 주식회사 오퍼스아시아 | Cosmetic composition with excellent skin moisturizing effect |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101983990B1 (en) * | 2017-04-12 | 2019-05-31 | 주식회사 지엘컴퍼니 | Cleansing composition comprising natural raw material extract and wet tissue comprising the same |
| KR102172448B1 (en) | 2018-11-28 | 2020-10-30 | 바이오스펙트럼 주식회사 | A antibacterial composition containing the defatted Camellia's seed extract and the feminine cleanser composition comprising the same |
| KR20200120280A (en) * | 2019-04-12 | 2020-10-21 | 전예진 | Cleanser composition women's vagina and method for manufacturing the same |
| KR102219594B1 (en) * | 2019-04-25 | 2021-02-24 | 담양죽순 영농조합법인 | Cosmetic composition comprising bamboo sprout peel extract |
| KR102036339B1 (en) | 2019-05-29 | 2019-10-25 | 동국대학교 경주캠퍼스 산학협력단 | Antiinflammatory, Antibacterial and Antifungal Composition containing Ulmus macrocarpa Hance, Leonurus sibiricus L. and Smilax china L. Root Extract and Pharmaceutical Composition for Preventing or Treating Vaginitis, and Composition for Female Cleansing Agent containing the same |
-
2021
- 2021-03-02 KR KR1020210027696A patent/KR102605440B1/en active IP Right Grant
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102165565B1 (en) | 2019-07-22 | 2020-10-14 | 주식회사 오퍼스아시아 | Cosmetic composition with excellent blemish and blemishes |
| KR102165567B1 (en) | 2019-07-22 | 2020-10-14 | 주식회사 오퍼스아시아 | Cosmetic composition with excellent skin moisturizing effect |
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220124027A (en) | 2022-09-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN106334067B (en) | Gynecological gel containing silver ion antibacterial agent, preparation method and application | |
| US5266318A (en) | Skin therapeutic mixture containing cold-processsed aloe vera extract, with yellow sap and aloin removed | |
| EP2278986B1 (en) | A product for topical administration | |
| JPH10298096A (en) | Synergistic herbal extract | |
| CN105943445B (en) | A kind of foodcare liquid and preparation method thereof | |
| CN106109534B (en) | Itching relieving repair liquid containing silver ion antibacterial agent, preparation method and application | |
| KR102366247B1 (en) | Wet wipe composition and its manufacturing method | |
| KR102345209B1 (en) | Sanitizer composition has excellent anti-viral effect, sterilization effect and skin moisturizing effect | |
| EP2367557B1 (en) | Composition for the treatment of inflammatory diseases of the oral and pharyngeal cavity | |
| CN114146014A (en) | Compound menthyl nicotinate plant polysaccharide emulsifiable paste and preparation method thereof | |
| KR102605440B1 (en) | Cosmetic composition for spraying or applying to women's Y-zone, which uses Leonurus sibiricus extract as the main ingredient | |
| KR102160699B1 (en) | Scalp Detox-Improving Hair Gel Cream Composition | |
| EP0668768B1 (en) | Composition for controlling dermatomycoses and their agents, as well as transpiration and bodily odours | |
| KR101082819B1 (en) | Functional composition derived from natural material for alleviating atopic dermatitis | |
| CN111973523A (en) | Anti-allergy purslane repairing mask and preparation method thereof | |
| KR102607410B1 (en) | Antibacterial composition containing extracts of above-ground parts of glechoma grandis and skin external preparation containing the same | |
| CN110787104A (en) | Compound traditional Chinese medicine toothpaste and preparation method and application thereof | |
| KR20100088478A (en) | Composition for treatment of a burn and preparing method thereof | |
| CN116236555A (en) | Mask fragrance spray containing Chinese herbal medicine active ingredients and preparation method thereof | |
| KR100977063B1 (en) | Herb medicine extracts containing body cleanser composition | |
| KR102292487B1 (en) | Composition for feminine hygiene care containing Copaiba resin extract | |
| KR102510213B1 (en) | The adhesive transparent wound covering material composition containing fumaria officinalis, pomegranate shell extract and comfrey leaf extract | |
| US11058738B2 (en) | Herbal preparation for accelerating wounds and skin inflammations healing, especially for treatment of herpes and acne, and its application | |
| CN111700825B (en) | Oily composition for oral health care, preparation method and application thereof | |
| AU2021103390A4 (en) | A Skincare Oil |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| E902 | Notification of reason for refusal | ||
| E701 | Decision to grant or registration of patent right | ||
| GRNT | Written decision to grant |