KR101879643B1 - Spray-type soft-melting polyurethane foam wound dressing and producing method thereof - Google Patents

Abstract

The present invention relates to a spray type soft polyurethane foam wound coating agent. When a certain time is elapsed after directly spraying the spray type soft polyurethane foam wound coating agent on a wounded area, the coating agent is foamed into the soft polyurethane foam such that a wound coating agent proper on a curved area of a human body can be obtained. By directly spraying the coating agent on a curved joint part or a hand part of a human body, a three-dimensional wound coating agent proper to the wounded area can be obtained. Since the wound coating agent has a soft foam shape, blood and exudate can be easily absorbed.

Description

[0001] Spray-type flexible polyurethane foam wound dressing and producing method [0002]

The present invention relates to a spray type flexible polyurethane foam wound dressing and a method of manufacturing the same. More particularly, the present invention relates to a spray type flexible polyurethane foam wound dressing which comprises a polyurethane prepolymer and a foamed composition separately charged into a spray container separated into two parts, And a foaming agent which is foamed into a polyurethane foam when it is aged, and a method for producing the same.

Treatment of wounds is a foundation of medicine and has a long history. According to Papyrus, it is said that from 5,000 BC, using oil, honey, and cotton for wound healing. Throughout history, many changes and developments have been made in the treatment of wounds. Since the publication of a study in 1962 by a zoologist Winter (Winter), which found that keeping wounds moist is more beneficial in healing than drying wounds and causing scabs, the usefulness of wet wounds Has been consistently proven and emphasized. A wet environment dressing method that prevents body fluid secreted from the wound from dehydrating or drying has now been found to facilitate wound healing.

Ideal wound dressings should maintain a moist environment between the wound and the wound dressing, have adequate absorbency and breathability, prevent dryness of the wound surface, and avoid burning of the surrounding normal skin. In addition, it has functionalities such as exchange of gas and prevention of intrusion of bacteria from the outside, and it should stick to the wound surface during exchange and not damage new tissue. In addition, it can be an ideal wound dressing if it is easy to observe the wound healing condition, is irritating, easy to use and economical. Research efforts to develop wound dressings that satisfy all of these ideal conditions are still underway.

In modern society, many people are suffering from serious burns and surgical injuries because of various safety accidents. In particular, when surgical injuries are caused to the joints and joints where there are many joints and valleys, the two-dimensional planar wound dressings which are commercially available are cut to fit the affected part, and then a plurality of pieces are dressed and then the second dressing So it was very difficult and uncomfortable to do dressing.

Korean Patent Registration No. 10-1560291 discloses a polyurethane-type surgical wound dressing and a method for manufacturing the same, which has a three-dimensional structure that is easy to apply to patients suffering from surgical injuries to a part having many joints and bending zones have. The wound dressing can innovatively reduce the time for dressing by doctors and nurses to patients who have suffered surgical injuries especially in the hand, and since the expensive wound dressing has to be cut and dressed, the remaining portion must be discarded. Which can reduce the economic burden of the patients. However, this type of wound dressing has various limitations in the size of the wrist, and there are restrictions on the use of the wrist because the patient has different surgical injuries.

Korean Patent Registration No. 10-1613904 and Korean Patent Registration No. 10-1125162 disclose a wound dressing material in which a polyurethane film is formed as a liquid wound dressing material directly applied to the affected part to protect the wound area when dried. Such wound dressings are easy to apply to the bending part of the human body, and the polyurethane film of the thin film is formed on the wound area after the volatile solution is evaporated by the body temperature of the human body. However, since the wound covering material forming the film form film is not capable of absorbing the exudates, it is difficult to apply to wounds causing exudates and hemorrhages, and it is difficult to apply to wounds with little exudates, scratches or sharp edges There is a limit that can be applied only to a slight wound of a slight vane.

Korean Patent Laid-Open Publication No. 10-2016-0075673 discloses a spray-type image dressing comprising a film-forming polymer and aluminum oxide particles. Such image dressing is applied to an image area by spraying, so that it is easy to use, but it is also formed as a thin film, and thus there is a problem that the exudate can not be absorbed as described above.

Korean Patent Laid-Open Publication No. 10-2014-0046871 discloses a rigid polyurethane foam for spraying which is prepared by mixing an isocyanate resin with a resin mixture composed of a polyol, a catalyst, a crosslinking agent, a physical property aid, and water as a foaming agent. Such a rigid polyurethane foam hardly has an elongation and is very hard, so that it is difficult to apply to various human body wounds such as a bent part or a water part of the human body, and when applied to a human body, the movement of the affected part is unnatural and can not absorb blood or exudates There is a problem. In addition, toxic tin-based catalysts or amine-based catalysts are used to form rigid polyurethane foams, which is detrimental when used in the human body.

In addition, polyurethane prepolymer terminated with isocyanate (NCO) and a foam composition are conventionally used in the manufacture of polyurethane foam wound dressings. However, the polyurethane prepolymer terminated with isocyanate has low NCO% when exposed to air, Since the polyurethane prepolymer and the foamed composition are stored in a separate container, it is difficult to apply the two materials quantitatively at the time of patient treatment to apply them to the wound. There is a problem.

Korean Patent Registration No. 10-1560291 Korean Patent Registration No. 10-1613904 Korean Patent Registration No. 10-1125162 Korean Patent Publication No. 10-2016-0075673 Korean Patent Publication No. 10-2014-0046871

Disclosure of the Invention The present invention has been made to solve the problems occurring when a conventional two-dimensional flat wound dressing is applied to an image and a surgical wound of a bent part of a human body such as a hand part and a joint part, And it is an object of the present invention to provide a spray-type flexible polyurethane foam wound dressing which can be foamed with a polyurethane foam when a predetermined time has elapsed so that a wound dressing suitable for a bent portion of a human body can be obtained.

To achieve these and other advantages and in accordance with the purpose of the present invention,

(a) adding an isocyanate to a polyol and reacting to prepare an isocyanate-terminated polyurethane prepolymer; (b) preparing a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose, and 3 to 7 parts by weight of a surfactant; (c) filling 10 to 90 parts by weight of the polyurethane prepolymer and 5 to 80 parts by weight of the propellant on one side of the spray container separated into two parts so that the contents are not mixed; And (d) filling the other side of the spray container with 10-90 parts by weight of the foam composition and 5-80 parts by weight of the propellant.

In the above production process, it is preferable to use an ethylene oxide / propylene oxide copolymer having a molecular weight of 3,000 or more and an ethylene oxide content of 20 to 90% by weight as the polyol.

In the above production process, the polyol and the isocyanate are preferably mixed in a weight ratio of 8 to 10: 1 to 2.

Further, according to the present invention,

A spray button for discharging the contents of the spray container and a nozzle through which the contents of the spray container are discharged,

10 to 90 parts by weight of an isocyanate-terminated polyurethane prepolymer prepared by reacting a polyol with isocyanate and 5 to 80 parts by weight of a propellant are filled in one side of the spray container,

10 to 90 parts by weight of a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose and 3 to 7 parts by weight of a surfactant, -80 parts by weight,

Wherein when the discharging button is pressed, the charged contents are mixed in a nozzle and discharged, followed by foaming to form a flexible polyurethane foam wound dressing.

In the wound dressing, the polyol is preferably an ethylene oxide / propylene oxide copolymer having a molecular weight of 3,000 or more and an ethylene oxide content of 20 to 90% by weight.

In the wound dressing, the polyol and isocyanate are preferably mixed in a weight ratio of 8 to 10: 1 to 2.

In the wound dressing, the nozzle is preferably a static mixer.

The spray-type flexible polyurethane foam wound dressing of the present invention can be sprayed directly onto the curved joints of a human body or on the hand, thereby obtaining a customized wound dressing having a three-dimensional structure suitable for a traumatic region. In addition, since the wound dressing obtained after spraying is in the form of a foamed soft polyurethane foam, it is easy to absorb blood and exudates. Especially, in case of a surgical wound such as an emergency where hemorrhage occurs frequently, a hemostatic agent Can also be utilized.

Therefore, as compared with the conventional products which were individually cut in the wound dressing according to the patient's condition, the patient can be treated promptly, thereby reducing the pain and medical burden of the patient and reducing the time required for hemostasis and dressing. Nurses can effectively manage more patients.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1A is a schematic diagram of an example of a spray type flexible polyurethane foam wound dressing of the present invention. FIG.
1B shows an example of a static mixer.
Fig. 2 shows an example using the spray-type flexible polyurethane foam wound dressing of the present invention.
Fig. 3 shows an example of use of the spray-type polyurethane foam wound dressing of the present invention when sprayed using a general nozzle.

The spray-type flexible polyurethane foam wound dressing of the present invention,

A spray button for discharging the contents of the spray container and a nozzle through which the contents of the spray container are discharged,

10 to 90 parts by weight of an isocyanate-terminated polyurethane prepolymer prepared by reacting a polyol with isocyanate and 5 to 80 parts by weight of a propellant are filled in one side of the spray container,

10 to 90 parts by weight of a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose and 3 to 7 parts by weight of a surfactant, -80 parts by weight,

When the discharging button is pushed, the charged contents are mixed in a nozzle and discharged, followed by foaming to form a soft polyurethane foam wound dressing.

The method of manufacturing a spray-type flexible polyurethane foam wound dressing according to the present invention comprises the steps of:

(a) adding an isocyanate to a polyol and reacting to prepare an isocyanate-terminated polyurethane prepolymer;

(b) preparing a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose, and 3 to 7 parts by weight of a surfactant;

(c) filling 10 to 90 parts by weight of the polyurethane prepolymer and 5 to 80 parts by weight of the propellant on one side of the spray container separated into two parts so that the contents are not mixed; And

(d) filling the other side of the spray container with 10-90 parts by weight of the foam composition and 5-80 parts by weight of the propellant.

Hereinafter, the present invention will be described in more detail.

1. Polyurethane Prepolymer  Produce

Polyol and isocyanate are reacted to prepare a polyurethane prepolymer.

First, the polyol is added, and the mixture is stirred at a stirring speed of 130 to 170 rpm, heated to 45 to 55 ° C, and stirred for 25 to 35 minutes. To the stirred polyol is added isocyanate under a nitrogen atmosphere. When the temperature starts to increase as the reaction proceeds, the reaction is continued at 75 to 85 ° C until the NCO content (%) reaches the theoretical value.

The NCO content (%) is preferably 3.0 to 7.0%, and most preferably 3.5 to 4.5%. When the NCO% is 3.0 or less, the viscosity of the synthesized polyurethane prepolymer becomes too high, so that injection after filling is not smooth, and when it is mixed with the foamed composition, the foam is formed at a high rate, On the contrary, when the NCO% is 7.0 or more, foam formation is not smooth and cell and pore are formed large, which is not suitable for use as a wound covering material.

The polyurethane prepolymer terminated with isocyanate is obtained by the above reaction, and the polyurethane prepolymer terminated with isocyanate can be foamed without additional catalyst by mixing the foam composition.

Examples of polyols include polypropylene oxide glycols, polyethylene oxide glycols, polytetramethylene ether glycols, ethylene oxide / propylene oxide copolymers, polytetrahydrofuran / ethylene oxide copolymers, polytetrahydrofuran / propylene oxide copolymers, polybutylene carbonate A mixture of at least one selected from glycol, polyhexamethylene carbonate glycol, polycaprolactone glycol, polyethylene adipate, polybutylene adipate, polyneopentyl adipate and polyhexamethylene adipate is used.

The polyurethane prepolymer of the present invention has hydrophilicity and foamed foam itself should be capable of absorbing moisture. Therefore, an ethylene oxide / propylene oxide copolymer having a molecular weight of 3,000 or more and an ethylene oxide content of 20 to 90% by weight is preferably used as the polyol It is particularly preferable to use them.

The isocyanates include aromatic, aliphatic and substituted isocyanates or mixtures thereof. Examples of the isocyanate compound include 2,4-toluene diisocyanate, 2,6-toluene diisocyanate, methylene diphenyl diisocyanate, 1,5-naphthalene diisocyanate, toluidine diisocyanate, hexamethylene- Diisocyanate, xylene diisocyanate, cyclohexylene-1,4-diisocyanate, lysine diisocyanate and tetramethylene-xylene diisocyanate are mixed and used. It is preferable to use a mixture of at least one selected from isophorone diisocyanate, 2,4-toluene diisocyanate, 2,6-toluene diisocyanate and methylene diphenyl isocyanate, and it is particularly preferable to use toluene diisocyanate desirable.

The polyol and the isocyanate are particularly preferably used in a weight ratio of 8 to 10: 1 to 2.

The polyurethane prepolymer may include known additives such as an antioxidant. Examples of the antioxidant include phenyl-beta-naphthalamine, cysteine hydrochloride, dibutylhydroxytoluene, nordihydrogu Azaretic acid, butylhydroxyanisole, phosphoric acid, citric acid, ascorbic acid, erysorbic acid, IRGANOX B1411, IRGANOX B1411, IRGANOX B1412, IRGANOX B1410, IRGANOX B101, IRGANOX B101, IRGANOX B900, IRGANOX B910, IRGANOX B105, , IRGANOX PS802, IRGAFOS P-EPQ, and the like. It is preferable to use one or more selected from among phosphoric acid, citric acid, dibutylhydroxytoluene, butylhydroxyanisole, IRGANOX 1010, IRGANOX 1035, IRGANOX 1076 and IRGANOX 1330 as the antioxidant. It is preferable that the antioxidant is added in the range of 0.05 to 5% by weight based on the total weight of the polyurethane prepolymer. The antioxidant is added together with the polyol.

2. Preparation of foam compositions

The foam composition comprises 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of cellulose, and 3 to 7 parts by weight of surfactant.

The main component of the foam composition is water, which is a foam, and since it is a main component of water, it can form a soft structure upon foaming.

Glycerin is a component added to provide a moisturizing function to the wound, and additionally participates in the foaming reaction with the water during the foaming reaction to delay the rate of the foaming reaction so that the foam gradually forms. Therefore, when the content of glycerin is too low, the foaming speed is very fast, so that it is difficult to form into a sheet form. In case of spraying, glycerin is added in an excessive amount because foaming is completed and hardened after leaving the nozzle.

Cellulose has a moisturizing function and acts as a thickening agent, and it imparts a ricosity to the foaming liquid itself, and plays a role of delaying the formation of foaming foam by first meeting with NCO. Representative examples include carboxymethylcellulose, carboxyethylcellulose and the like.

As the surfactant, the size of the pores of the polyurethane foam and the opening ratio of the pores are controlled, and a known surfactant is selected and used. Examples of the surfactant include F-68, F-87, F-88, F-108 and F-127 of BASF Corporation, ethylene oxide / propylene oxide block copolymer, L- 688, L-5420, SZ-1703, L-6900, L-3150, Y-7931, L-1580, L-5340, L-5333, L-6701, L-5740M, L-3002 and L-626 . It is preferable to use a high-molecular-weight medical grade surfactant composed of an ethylene oxide / propylene oxide block copolymer as a surfactant.

The foamed composition may further contain components such as pigments, drugs, absorption aids and the like as needed, and these components are used according to known capacity and method.

3. Charging in spray bottle

The polyurethane prepolymer and the foamed composition are each filled in a spray container of a completely separated structure in two parts so that the contents of the respective parts are not mixed. As a material of the spray container, a commonly used material can be used, and aluminum is typically used. When the two liquids are mixed, they can not be used immediately because they are foamed.

10 to 90 parts by weight of a polyurethane prepolymer and 5 to 80 parts by weight of a propellant are charged into one side of the spray container. Preferably 30 to 50 parts by weight of a polyurethane prepolymer and 30 to 50 parts by weight of a propellant, and most preferably 30 to 40 parts by weight of a polyurethane prepolymer and 60 to 70 parts by weight of a propellant. And 10 to 90 parts by weight of the foam composition and 5 to 80 parts by weight of the propellant are charged to the other side of the spray container. Preferably, 30 to 50 parts by weight of the foam composition and 30 to 50 parts by weight of the propellant are filled, and most preferably 30 to 40 parts by weight of the foam composition and 60 to 70 parts by weight of the propellant are filled. As the propellant, a liquefied gas such as dimethyl ether or LPG may be used, and it is more preferable to use dimethyl ether.

10 to 90 parts by weight of a polyurethane prepolymer and 5 to 80 parts by weight of a propellant are charged into one side of the spray container. And 10 to 90 parts by weight of the foam composition and 5 to 80 parts by weight of the propellant are charged to the other side of the spray container. As the propellant, a liquefied gas such as dimethyl ether or LPG may be used, and it is more preferable to use dimethyl ether.

The mixing ratio of the polyurethane prepolymer and the foamed composition may be different within the above range, and it is particularly preferable that the polyurethane prepolymer is mixed and discharged at a weight ratio of 1: 1.

When the button on the top of the spray container is sprayed, the polyurethane prepolymer and the foam composition are mixed with each other through the nozzle, and the mixture is applied to the wound area. When a predetermined time has elapsed, the polyurethane foam is foamed into a soft polyurethane foam. The time for completion of the foaming and covering with the wound dressing varies depending on the composition of the foam mixture, but is usually completed within 1 to 5 minutes.

As the nozzle, a normal nozzle can be used, but it is more preferable to use a static mixer. When a static mixer is used, the polyurethane prepolymer and the foamed composition are uniformly mixed in the discharge process, and the foam is foamed into a uniform and dense polyurethane foam having a uniform pore size and a cell size. An example of a static mixer is shown in FIG.

The spray-type flexible polyurethane foam wound dressing of the present invention thus formed is formed of a hydrophilic polyurethane foam to protect the wound site and to absorb blood and exudates. In addition, since it is applied by spraying, it is suitably formed in the bending part of the human body, and can be quickly applied to the patient in an emergency in which hemostasis is required.

Hereinafter, the present invention will be described in more detail with reference to examples. The following examples illustrate the invention and are not to be construed as limiting the scope of the invention.

< Example  1>

Spray type flexible polyurethane foam Wound dressing  Produce

1. Polyurethane Prepolymer  Produce

A polyurethane prepolymer was prepared at the compounding ratio shown in Table 1 below.

First, an ethylene oxide / propylene oxide copolymer polyol was charged into the reactor, heated to 50 ° C, and stirred for 30 minutes. After stirring, toluene diisocyanate (TDI) was added to the reaction mixture. When the reaction started to increase, the reaction was carried out at 80 ° C.

Raw material Input (g) Ethylene oxide / propylene oxide copolymer polyol 890 Toluene diisocyanate (TDI) 145 The viscosity of the synthesized prepolymer (cps / at 30 &lt; 0 &gt; C) 4,990

By the reaction, a polyurethane prepolymer terminated with a liquid isocyanate is obtained.

2. Preparation of foam compositions

A foam composition was prepared in the ratio shown in Table 2 below.

Raw material Input (g) Deionized water 1,000 Carboxymethylcellulose 20 F-127 5 glycerin 50 Formulation (g) 1,075

3. Spray type polyurethane foam Wound dressing  Produce

As shown in Fig. 1A, 50 parts by weight of the polyurethane prepolymer (liquid A) and 50 parts by weight of dimethyl ether were charged into one part of an aluminum container divided into two parts, and 50 parts by weight of the foamed composition (liquid B) And 50 parts by weight of dimethyl ether. The static mixer 2 is used as the injection nozzle, and when the discharge button 1 is pressed, the two liquids are mixed in the static mixer 2 and discharged. When the discharged foamed mixture solution has elapsed in about 2 to 3 minutes, a foam-like wound dressing material is obtained.

< Example  2>

Spray type flexible polyurethane foam Wound dressing  use

The spray-type flexible polyurethane foam wound dressing prepared in Example 1 was used in the hand and is shown in Fig.

As shown in FIG. 2, (a) the coating is applied directly to the wound area, and (b) foam is formed after a certain time, thereby forming a foam-like wound dressing. If the bubble is completely bended, it does not fall off the bent part but is attached to the bruise part as it is bent (c). (D) shows a second dressing material for protecting the waterproof and polyurethane foam wound dressings from the polyurethane foam wound dressings using an adhesive polyurethane film dressing material.

< Comparative Example >

A polyurethane prepolymer and a foamed composition were prepared at the same blending ratio as in Example 1 above.

50 parts by weight of the prepared polyurethane prepolymer and 50 parts by weight of the foamed composition were stirred at 3,000 rpm for 10 seconds and supplied onto a silicone release paper (Yulchon Chemical Co.) fixed at an angle of 45 degrees to flow the foamed mixture along the inclined surface. After 2 minutes passed after the foaming mixture solution was allowed to flow down, a polyurethane foam layer having a tacky gel state was formed, dried in a hot air drier at 100 ° C for 3 minutes, and dried in a hot air drier at 70 ° C for 24 hours And then aged to prepare a two-dimensional planar wound dressing of 5 mm thickness.

< Experimental Example  1>

Wound dressing  Check physical properties

Physical properties of the wound dressings of Example 1 and Comparative Example were measured as follows.

The spray-type flexible polyurethane foam wound dressing of Example 1 was prepared by coating a certain amount of the wound dressing on a release paper and then having a thickness of 5 mm.

The specimens were prepared in the size of 5 cm × 5 cm in Example 1 and Comparative Example, and the absorption rate of the wound interface, the absorbency (%) and the moisture permeability of the entire wound covering material were measured as follows. .

(1) Wounds Contact surface  Absorption rate

About 0.5 cc of distillation was dropped using a pipette about 2 cm away from the specimen, and the time until the distilled water was completely absorbed to the surface of the wound dressing was measured. A total of 20 samples were measured and their mean values were obtained.

(2) Wound dressing  Total absorbency (%)

The initial weight (A) of the wound dressing was allowed to stand at room temperature for 24 hours. The initial weight (A) was measured and stored for 24 hours in distilled water at 37 ° C. The weight of the wound dressing was measured. Absorbance was calculated from the measured weight using the following equation.

Absorption (%) = (B-A) / A x 100

(3) Moisture permeability

The moisture permeability was measured using a thermo-hygrostat according to ASTM E 96-94 (Desiccant Method). At this time, the temperature of the thermo-hygrostat was 37 ° C and the relative humidity was 80%.

division Example 1 Comparative Example Absorption rate of wound interface (sec) 2 3 Absorbency (%) of whole wound dressing 1,120 1,190 Water vapor permeability (g / m 2/24 hrs) 9,150 8,980

As can be seen from the results in Table 3, the spray-type flexible polyurethane foam wound dressing of the present invention is superior to the two-dimensional planar wound dressing of the comparative example in that the wound dressing, which is one of the physical characteristics essential to the wound dressing, The effect of absorption rate, absorption degree, and moisture permeability is not low. Therefore, it can be usefully used for dressing surgical wounds such as bending part joints and hand parts of a human body in which a large amount of exudates are generated, images and the like.

< Experimental Example  2>

Wound dressing Wound healing effect  Confirm

The wound healing effects of the wound dressings of Example 1 and Comparative Example were measured as follows.

The wound-type polyurethane foam wound dressing of Example 1 was coated with a certain amount on a release paper to prepare a wound dressing with a thickness of 5 mm.

The wound dressing materials of Example 1 and Comparative Example were 5 cm × 5 cm in size, and the wound healing effect was confirmed by using 250-300 g of rat body weight around 6-8 weeks after birth.

First, the rats were anesthetized with abdominal aortic aneurysm. The intubation or oxygen supply was not performed separately, but the ventilation of the room air was made voluntarily. Surgery of the side and back was completely removed, and the hair was completely removed with an epilator. The surgical site was disinfected with povidone and alcohol, and aseptic surgery was performed as far as possible. After making skin defect of 80πmm2 on the back area, the wound area was washed with physiological saline solution and wiped with dry gauze. Then, the wound dressing material was attached about 1cm wider than the wound area, 2 pieces of gauze were covered thereon, and the wound dressing material was prevented from falling off The body was lightly fixed with a resilient bandage. After 3 days, 6 days, 9 days, 12 days, and 15 days after dressing, dressings were changed. Degree of epidermalization of skin defects over time and desorption of new tissue at dressing exchange and tissue biopsy using optical microscope And the wound healing effect was measured. The measured results were classified into four stages of E (Excellent), G (Good), F (Fair) and P (Poor), and the results are shown in Table 4 below.

division Example 1 Comparative Example Wound healing effect E E

As can be seen from the results of Table 4 above, the spray type flexible polyurethane foam wound dressing of the present invention shows that the wound healing effect in the in vivo test in an animal experiment is superior to the conventional two-dimensional flat wound dressing Respectively. Therefore, it can be usefully used for dressing surgical wounds such as bending part joints and swollen parts of the human body and the like, where exudates are generated in large amounts.

< Experimental Example  3>

In vitro cytotoxicity

The cytotoxicity of the wound dressings of Example 1 and Comparative Example was evaluated as follows.

The wound-type polyurethane foam wound dressing of Example 1 was coated with a certain amount on a release paper to prepare a wound dressing with a thickness of 5 mm.

The wound dressings of Example 1 and Comparative Example were 5 cm × 5 cm in size and subjected to cell culture test. Experimental methods are ISO 10993 Biological evaluation of medical devices Part 5: Test for in vitro cytotoxicity , and Test on extracts. In the test group, 20 ml of MEM medium was added per 25 ㎠ of the surface area of the specimen and the mixture was extracted at 37 ° C for 24 hours. Cells were cultured for 3-4 days in a minium essential medium (MEM) containing 10% Fatal bovine serum. L-929 cells were aliquoted at a concentration of 1 × 10 ⁵ cells and monolayer was cultured in a MEM culture medium. After the medium was removed, the extract was treated and cultured at 37 ° C. for 1, 3, 5 and 7 days in a 5% CO ₂ incubator Cells were observed with a post-microscope. The cell proliferation behavior was evaluated by MTT assay as an evaluation criterion for cytotoxicity shown in Table 5 below. The results of the experiment are shown in Table 6 below.

As can be seen from the results of Tables 5 and 6 above, the spray-type flexible polyurethane foam wound dressing of the present invention is an in- vivo test ( in vivo test showed that the wound healing effect was similar to that of conventional two dimensional planar wound dressings and that the in vitro test results were also grade 1 and were not different from conventional two dimensional planar dressings. Therefore, it can be usefully used for dressing surgical wounds such as bending part joints and swollen parts of the human body and the like, where exudates are generated in large amounts.

(1): Discharge button (2) Static mixer

Claims (7)

(a) adding an isocyanate to a polyol and reacting to prepare an isocyanate-terminated polyurethane prepolymer;
(b) preparing a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose, and 3 to 7 parts by weight of a surfactant;
(c) filling 10 to 90 parts by weight of the polyurethane prepolymer and 5 to 80 parts by weight of the propellant on one side of the spray container separated into two parts so that the contents are not mixed; And
(d) filling 10-90 parts by weight of the foam composition and 5-80 parts by weight of the propellant onto the other side of the spray container. The method according to claim 1,
Wherein the polyol is an ethylene oxide / propylene oxide copolymer having a molecular weight of 3,000 or more and an ethylene oxide content of 20 to 90% by weight. 3. The method according to claim 1 or 2,
Wherein the polyol and the isocyanate are mixed at a weight ratio of 8 to 10: 1 to 2. A spray button for discharging the contents of the spray container and a nozzle through which the contents of the spray container are discharged,
10 to 90 parts by weight of an isocyanate-terminated polyurethane prepolymer prepared by reacting a polyol with isocyanate and 5 to 80 parts by weight of a propellant are filled in one side of the spray container,
10 to 90 parts by weight of a foam composition comprising 900 to 1,100 parts by weight of deionized water, 40 to 60 parts by weight of glycerin, 15 to 25 parts by weight of a cellulose and 3 to 7 parts by weight of a surfactant, -80 parts by weight,
Characterized in that when the discharging button is pressed, the filled contents are mixed in the nozzle and discharged, followed by foaming to form a soft polyurethane foam wound dressing. 5. The method of claim 4,
Wherein the polyol is an ethylene oxide / propylene oxide copolymer having a molecular weight of 3,000 or more and an ethylene oxide content of 20 to 90% by weight. The method according to claim 4 or 5,
Characterized in that the polyol and the isocyanate are mixed in a weight ratio of from 8 to 10: 1 to 2. The spray for forming a flexible polyurethane foam wound dressing. 5. The method of claim 4,
Wherein the nozzle is a static mixer. &Lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt; A spray for forming a flexible polyurethane foam wound dressing.

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