CN104083590B - Aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof - Google Patents
Aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof Download PDFInfo
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- CN104083590B CN104083590B CN201410350762.4A CN201410350762A CN104083590B CN 104083590 B CN104083590 B CN 104083590B CN 201410350762 A CN201410350762 A CN 201410350762A CN 104083590 B CN104083590 B CN 104083590B
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Abstract
The invention discloses aloe barbadensis Miller composition gels freeze-dried powder external use plaster, including patch, aloe barbadensis Miller composition gels freeze-dried powder is placed with the adsorptive pads of patch；Aloe barbadensis Miller composition gels freeze-dried powder is made up of following component：Gotu Kola P.E, aloe vera gel juice, octyl glycidyl ether, carbomer, HPMC, natural polysaccharide alginate, N sodium lauroyl sarcosines, lauryl glucoside, vitamin B5, plant type cereal amino acid extract.The present invention provides a kind of aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof, avoid wound patch using when turn white, promote the resume speed of wound, it is dominant in terms of the percutaneous absorbtion rate in initial dose stage, effective blood concentration can be maintained for a long time and shown excellent period of validity.
Description
Technical field
The present invention relates to a kind of patch and preparation method thereof, particularly relates to a kind of Curacao used at wound
Aloe composition gel freeze-dried powder external use plaster and preparation method thereof.
Background technology
At present, the external use plaster and the adsorptive pads for the patch of Wound contact used in wound opening position, the adsorptive pads
For the common cotton pad by sterilization, being only capable of playing prevents Wound contact air or by allotrylic effect.External use plaster makes
Used time will completely cut off to wound site, also so that wound can not enter while avoiding wound with air and abnormal contact
Row is ventilative, and wound is sealed in patch, it is easy to turns white, and its speed recovered is also more slowly, or even also result in wound
Purulence is sent out, is unfavorable for the normal recovery of wound.
The content of the invention
In view of this, the present invention provides a kind of aloe barbadensis Miller composition gels freeze-dried powder external use plaster and its making side
Method, avoid wound patch using when turn white, promote the resume speed of wound, the percutaneous absorbtion rate side in initial dose stage
Face is dominant, and can maintain effective blood concentration for a long time and show excellent period of validity.
To solve above technical problem, the technical scheme is that：
Aloe barbadensis Miller composition gels freeze-dried powder external use plaster, including patch, storehouse is placed with the adsorptive pads of patch
Drag-line aloe composition gel freeze-dried powder；The aloe barbadensis Miller composition gels freeze-dried powder by following parts by weight raw material group
Part composition：1~10 part of Gotu Kola P.E；3~12 parts of aloe vera gel juice；5~10 parts of octyl glycidyl ether；Card ripple
1~4 part of resin；5~20 parts of HPMC；2~4 parts of natural polysaccharide alginate；N- sodium lauroyl sarcosines 5~10
Part；5~10 parts of lauryl glucoside；1~2 part of vitamin B5；5~10 parts of plant type cereal amino acid extract.
Further, above-mentioned aloe barbadensis Miller composition gels freeze-dried powder is made up of the material component of following parts by weight：
3~7 parts of Gotu Kola P.E；5~10 parts of aloe vera gel juice；7~8 parts of octyl glycidyl ether；Carbomer 2~3
Part；10~15 parts of HPMC；2~4 parts of natural polysaccharide alginate；6~9 parts of N- sodium lauroyl sarcosines；Bay
6~9 parts of base glucoside；1~2 part of vitamin B5；6~9 parts of plant type cereal amino acid extract.
Optimal, the aloe barbadensis Miller composition gels freeze-dried powder is made up of the material component of following parts by weight：Product
Avenge careless 5 parts of extract；7 parts of aloe vera gel juice；7 parts of octyl glycidyl ether；3 parts of carbomer；Hydroxypropyl methylcellulose
13 parts of element；3 parts of natural polysaccharide alginate；7 parts of N- sodium lauroyl sarcosines；7 parts of lauryl glucoside；2 parts of vitamin B5；
7 parts of plant type cereal amino acid extract.
The preparation method of aloe barbadensis Miller composition gels freeze-dried powder external use plaster, comprises the following steps：
A, No.1 composition makes, and Gotu Kola P.E, carbomer and natural polysaccharide alginate are added into storehouse draws
In rope Aloe gel juice, No.1 composition is obtained after being stirred for uniformly；
B, No. two compositions make, by HPMC, N- sodium lauroyl sarcosines, vitamin B5 and plant type
Cereal amino acid extract is added in octyl glycidyl ether, and No. two compositions are obtained after being stirred for uniformly；
C, No. three compositions make, and No.1 composition are mixed with No. two compositions, and the mixture stirs
Then obtain No. three compositions；
D, No. four compositions are made, and lauryl glucoside is added in blend compositions, are obtained after being stirred for uniformly
No. four compositions；
E, freeze-dried powder makes；
F, freeze-dried powder is inserted in adsorptive pads.
Step E is that obtained in step D No. four compositions are first frozen into solid-state in an aseptic environment, then by solid-state
Composition is placed in vacuum environment and heated so that water sublimed therein is dried to obtain freeze-dried powder.
Compared with prior art, the present invention has following beneficial effect：
Gotu Kola P.E has the synergy effect mutually cooperateed with the active material in aloe vera gel juice in the present invention
Should, epithelial hyperplasia, the stroke for promoting normal granulation tissue generation, guiding normal collagenous fibres on the one hand can be activated, is added
The normal healing of fast wound or the surface of a wound, it on the other hand can also suppress fibroblast proliferation, prevent its hyperplasia and without expanding
Dissipate, so as to prevent the formation of abnormal scars, while also there is anti-inflammation, the function of antipruritic；
Preferably, octyl glycidyl ether of the present invention has certain moisture retention, product is set to feel to moisten when using to relax
It is suitable, while the antibacterial effect of product can also be lifted, strengthen it and suppress the ability of abnormal smell of body；
Preferably, the carbomer in the present invention is used as thickening stabilizing agent with HPMC compounding so that matches somebody with somebody
The effect of square patch is more stable and lasting.
Embodiment
The core thinking of the present invention is to provide a kind of aloe barbadensis Miller composition gels freeze-dried powder external use plaster and its making
Method, avoid wound patch using when turn white, promote the resume speed of wound, the percutaneous absorbtion rate in initial dose stage
Aspect is dominant, and can maintain effective blood concentration for a long time and show excellent period of validity.
In order that those skilled in the art more fully understands technical scheme, with reference to specific embodiment pair
The present invention is described in further detail.
Embodiment 1
A, No.1 composition makes, by 1 part of Gotu Kola P.E, 1 part of carbomer and 2 parts of natural polysaccharide alginates
Add in 3 parts of aloe vera gel juice, No.1 composition is obtained after being stirred for uniformly；
B, No. two compositions make, by 5 parts of HPMCs, 5 parts of N- sodium lauroyl sarcosines, 1 part of vitamin B5
And 5 parts of plant type cereal amino acid extracts are added in 5 parts of octyl glycidyl ethers, No. two groups are obtained after being stirred for uniformly
Compound；
C, No. three compositions make, and No.1 composition are mixed with No. two compositions, and the mixture stirs
Then obtain No. three compositions；
D, No. four compositions are made, and 5 portions of lauryl glucosides are added in blend compositions, are obtained after being stirred for uniformly
Obtain No. four compositions；
E, freeze-dried powder is made, and obtained in step D No. four compositions are frozen into solid-state in an aseptic environment, then will be solid
The composition of state is placed in vacuum environment and heated so that water sublimed therein is dried to obtain freeze-dried powder；
F, freeze-dried powder is inserted in adsorptive pads.
Embodiment 2
A, No.1 composition makes, by 10 parts of Gotu Kola P.Es, 4 parts of carbomers and 4 parts of natural polysaccharide alginic acids
Salt is added in 12 parts of aloe vera gel juice, and No.1 composition is obtained after being stirred for uniformly；
B, No. two compositions make, by 20 parts of HPMCs, 10 parts of N- sodium lauroyl sarcosines, 2 parts of vitamins
B5 and 10 part of plant type cereal amino acid extract is added in 10 parts of octyl glycidyl ethers, and two are obtained after being stirred for uniformly
Number composition；
C, No. three compositions make, and No.1 composition are mixed with No. two compositions, and the mixture stirs
Then obtain No. three compositions；
D, No. four compositions are made, and 10 portions of lauryl glucosides are added in blend compositions, after being stirred for uniformly
Obtain No. four compositions；
E, freeze-dried powder is made, and obtained in step D No. four compositions are frozen into solid-state in an aseptic environment, then will be solid
The composition of state is placed in vacuum environment and heated so that water sublimed therein is dried to obtain freeze-dried powder；
F, freeze-dried powder is inserted in adsorptive pads.
Embodiment 3
Optimal, the aloe barbadensis Miller composition gels freeze-dried powder is made up of the material component of following parts by weight：Product
Avenge careless 5 parts of extract；7 parts of aloe vera gel juice；7 parts of octyl glycidyl ether；3 parts of carbomer；Hydroxypropyl methylcellulose
13 parts of element；3 parts of natural polysaccharide alginate；7 parts of N- sodium lauroyl sarcosines；7 parts of lauryl glucoside；2 parts of vitamin B5；
7 parts of plant type cereal amino acid extract.
A, No.1 composition makes, by 5 parts of Gotu Kola P.Es, 3 parts of carbomers and 3 parts of natural polysaccharide alginates
Add in 7 parts of aloe vera gel juice, No.1 composition is obtained after being stirred for uniformly；
B, No. two compositions make, by 13 parts of HPMCs, 7 parts of N- sodium lauroyl sarcosines, 2 parts of vitamin B5s
And 7 parts of plant type cereal amino acid extracts are added in 7 parts of octyl glycidyl ethers, No. two groups are obtained after being stirred for uniformly
Compound；
C, No. three compositions make, and No.1 composition are mixed with No. two compositions, and the mixture stirs
Then obtain No. three compositions；
D, No. four compositions are made, and 7 portions of lauryl glucosides are added in blend compositions, are obtained after being stirred for uniformly
Obtain No. four compositions；
E, freeze-dried powder is made, and obtained in step D No. four compositions are frozen into solid-state in an aseptic environment, then will be solid
The composition of state is placed in vacuum environment and heated so that water sublimed therein is dried to obtain freeze-dried powder；
F, freeze-dried powder is inserted in adsorptive pads.
Experimental example 1
The rabbit that the patch of common patch and embodiment 1~3 is shaved to back hair in advance in laboratory to more enters
Row contrast experiment, rabbit back of being in shaves hair location, and standardized bar is about 1CM wound respectively, by common patch and embodiment 1
~3 patch is respectively acting on the wound site of four different rabbit, and its result is as shown in table 1 below.
Table 1
There is slight blushing the wound that embodiment 1~3 acts on after experiment, and no inflammation hair purulence phenomenon produces；It is and common
Patch effect wound blushing is more serious, is also having moderate inflammation hair purulence phenomenon to occur close to wound.Can by table 1
See, the effect of the present embodiment more common patch of its effect when acting on the wound of 1CM length is more preferable, is capable of the dimension of longer time
Hold effective blood concentration.
Experimental example 2
It is with the difference of experimental example 1, this experimental example rabbit back of being in marks a wound for being about 3CM, its result
It is as shown in table 2 below.
Table 2
There is slight blushing the wound that embodiment 1~3 acts on after experiment, and embodiment 1 has minor irritation as use, real
Apply example 2~3 and make use without inflammation hair purulence phenomenon；Common patch effect wound blushing is more serious, has close to wound
Heavier inflammation hair purulence phenomenon occurs.
It the above is only the preferred embodiment of the present invention, it is noted that above-mentioned preferred embodiment is not construed as pair
The limitation of the present invention, protection scope of the present invention should be defined by claim limited range.For the art
For those of ordinary skill, without departing from the spirit and scope of the present invention, some improvements and modifications can also be made, these change
Enter and retouch and also should be regarded as protection scope of the present invention.
Claims (3)
1. aloe barbadensis Miller composition gels freeze-dried powder external use plaster, it is characterised in that be placed with storehouse in the adsorptive pads of patch
Drag-line aloe composition gel freeze-dried powder；The aloe barbadensis Miller composition gels freeze-dried powder by following parts by weight raw material group
Part composition：5 parts of Gotu Kola P.E；7 parts of aloe vera gel juice；7 parts of octyl glycidyl ether；3 parts of carbomer；Hydroxypropyl
13 parts of methylcellulose；3 parts of natural polysaccharide alginate；7 parts of N- sodium lauroyl sarcosines；7 parts of lauryl glucoside；Dimension life
Plain 2 parts of B5；7 parts of plant type cereal amino acid extract.
2. the preparation method of aloe barbadensis Miller composition gels freeze-dried powder external use plaster according to claim 1, its feature
It is, comprises the following steps：
A, No.1 composition is made, and Gotu Kola P.E, carbomer and natural polysaccharide alginate are added into Curacao reed
In luxuriant growth gel juice, No.1 composition is obtained after being stirred for uniformly；
B, No. two compositions make, by HPMC, N- sodium lauroyl sarcosines, vitamin B5 and plant type cereal
Amino acid extract is added in octyl glycidyl ether, and No. two compositions are obtained after being stirred for uniformly；
C, No. three compositions make, and No.1 composition are mixed with No. two compositions, and the mixture is stirred then
Obtain No. three compositions；
D, No. four compositions are made, and lauryl glucoside is added in blend compositions, and No. four are obtained after being stirred for uniformly
Composition；
E, freeze-dried powder makes；
F, freeze-dried powder is inserted in adsorptive pads.
3. the preparation method of aloe barbadensis Miller composition gels freeze-dried powder external use plaster according to claim 2, its feature
It is, step E is that obtained in step D No. four compositions are first frozen into solid-state in an aseptic environment, then by the group of solid-state
Compound is placed in vacuum environment and heated so that water sublimed therein is dried to obtain freeze-dried powder.
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| CN201410350762.4A CN104083590B (en) | 2014-07-22 | 2014-07-22 | Aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof |
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| CN201410350762.4A CN104083590B (en) | 2014-07-22 | 2014-07-22 | Aloe barbadensis Miller composition gels freeze-dried powder external use plaster and preparation method thereof |
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| CN104083590B true CN104083590B (en) | 2017-12-05 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106267168A (en) * | 2015-05-12 | 2017-01-04 | 浙江海汇医疗科技有限公司 | A kind of women breast-feeding their children paste with cracked nipple |
| CN108969508A (en) * | 2018-09-21 | 2018-12-11 | 珠海汉盈科技有限公司 | The spontaneous hotting mask of promotion burn wound reparation containing aloe extract |
| CN115414306A (en) * | 2022-08-26 | 2022-12-02 | 广州舒客实业有限公司 | Oral anti-inflammatory composition, gel and application in oral care product |
| CN115487128A (en) * | 2022-08-26 | 2022-12-20 | 广州舒客实业有限公司 | Composition and gel for repairing oral mucosa and application of composition and gel in oral care product |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806855A (en) * | 2005-11-30 | 2006-07-26 | 合肥恒星医疗用品有限公司 | Wet wound dressing containing plant effective ingredient |
| CN101491492A (en) * | 2009-02-04 | 2009-07-29 | 北京如日中天科技发展有限公司 | Full aloe gelatin |
| CN102423249A (en) * | 2011-11-25 | 2012-04-25 | 铜陵洁雅生物科技股份有限公司 | Medical nursing wet tissue with functions of deodorizing and preventing bedsore and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1806855A (en) * | 2005-11-30 | 2006-07-26 | 合肥恒星医疗用品有限公司 | Wet wound dressing containing plant effective ingredient |
| CN101491492A (en) * | 2009-02-04 | 2009-07-29 | 北京如日中天科技发展有限公司 | Full aloe gelatin |
| CN102423249A (en) * | 2011-11-25 | 2012-04-25 | 铜陵洁雅生物科技股份有限公司 | Medical nursing wet tissue with functions of deodorizing and preventing bedsore and preparation method thereof |
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