CN112274689A

CN112274689A - Waterproof wound-protecting liquid dressing and preparation method thereof

Info

Publication number: CN112274689A
Application number: CN201910671350.3A
Authority: CN
Inventors: 王风华; 彭长生; 神丹; 丁显玉; 顾升荣
Original assignee: Jiangsu Changjiyong Biotechnology Co ltd
Current assignee: Jiangsu Changjiyong Biotechnology Co ltd
Priority date: 2019-07-24
Filing date: 2019-07-24
Publication date: 2021-01-29

Abstract

The invention relates to a waterproof wound-protecting liquid dressing and a preparation method thereof. In particular to a liquid dressing which is convenient to be smeared on a wound, can quickly form a film, can quickly isolate the wound from the outside, and can block water and bacteria and a preparation method thereof. The preparation method comprises the following steps: adding a film-forming agent, a tackifier, a plasticizer, a bacteriostatic agent and a solvent into a reaction container, heating and stirring to form uniform gel, vacuumizing to remove bubbles, and filling to obtain the waterproof wound-protecting liquid dressing. The liquid dressing prepared by the method has the advantages of film forming property, extensibility, waterproof performance, air permeability, heavy metal residue detection and qualified initial pollution bacteria detection. The invention is suitable for small wound surfaces, has the advantages of rapid film forming, wound surface sealing and protection, can be used for joint combination parts, does not influence bathing, swimming and the like, automatically falls off after 48 hours, can replace solid band-aid and the like.

Description

Waterproof wound-protecting liquid dressing and preparation method thereof

Technical Field

The invention relates to a waterproof wound-protecting liquid dressing and a preparation method thereof. In particular to a waterproof wound-protecting liquid dressing which is convenient to be smeared on a wound, enables the wound to be quickly isolated from the outside and has the bacterium-resisting effect and a preparation method thereof. Belongs to the technical field of wound nursing medical instruments.

Background

For small wounds such as scratches and abrasions in daily life, people usually adopt the band-aid for treatment. The traditional non-woven fabric band-aid has obvious use defects, not only influences the free movement of a wound part, but also easily whitens the skin of the part where the adhesive tape is stuck, and even causes adverse reactions of skin allergy to some people. In recent years, liquid dressing begins to enter daily life as a novel band-aid, is smeared on a wound, is not limited by a joint, can form a film quickly, is not required to be fixed by an adhesive tape, and is low in cost. According to the invention, the film-forming agents polyvinyl alcohol and polyvinyl butyral are modified, phenolic resin and polyacrylic resin materials are used as tackifiers, plasticizers and bacteriostats are added, and the liquid dressing is modified, so that the film-forming agent has excellent ductility and flexibility, good waterproof and breathable effects, and can fall off naturally after two days.

The phenolic resin and polyacrylic resin auxiliary materials have good performances of strong adhesive force, no toxicity, aging resistance, heat resistance and the like. As an environment-friendly material and a drug auxiliary material, the liquid dressing can increase the ductility and the flexibility of the product, can improve the film forming effect of the liquid dressing and increase the comfort of film forming in the process of acting with film forming agents such as polyvinyl alcohol and polyvinyl butyral, and has practical significance.

Disclosure of Invention

The invention aims to provide a waterproof and wound-protecting liquid dressing and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the waterproof wound protecting liquid dressing consists of filming agent 6-16 wt%, tackifier 0.5-3 wt%, plasticizer 3-12 wt%, bacteriostat 0.5-2 wt% and solvent 67-90 wt%.

The film-forming agent is the mixture of polyvinyl alcohol and polyvinyl butyral, and the mixing ratio is 0.5-1.0;

the tackifier is one of phenolic resin and polyacrylic resin;

the plasticizer is a mixture of two or more than three of diethyl/butyl phthalate, ethyl acetate, glycerol, rosin, propylene glycol and castor oil;

the bacteriostatic agent is one or more of ethylparaben, phenoxyethanol and chlorphenesin.

The solvent is one or two of isopropanol and absolute ethyl alcohol, wherein the mixing ratio of the isopropanol to the absolute ethyl alcohol is 0.5-1.0.

A preparation method of a waterproof and wound-protecting liquid dressing comprises the following steps:

1) adding a solvent, a plasticizer, a film forming agent, a tackifier and a bacteriostatic agent into a reaction container in sequence, and stirring at a low speed of 50-100rpm for 2-5 hours at a temperature of 50-70 ℃ to form uniform gel;

2) standing or vacuumizing for a short time to remove bubbles, and filling to obtain the liquid dressing product.

The packaging of the waterproof wound-protecting liquid dressing selects a packaging tube or a bottle with strong sealing performance, preferably a section-smearing type packaging tube, a bottle with a brush or a sheet, a vacuum bottle and the like.

The film-forming agent, the plasticizer, the bacteriostatic agent and the solvent can be prepared into liquid convenient to apply, so that the liquid can be quickly formed into a film, the wound is quickly isolated from the outside, the normal movement of the applied part is not influenced, and the cost is low.

Detailed Description

Example 1: taking the configuration 100g as an example, take by weight:

polyvinyl alcohol 5g

Polyvinyl butyral 10g

Phenolic resin 0.8g

Phthalic acid diethyl ester 5g

Glycerol 3g

Nipagin ethyl ester 0.5g

Isopropanol 27.7g

48g of absolute ethyl alcohol

1) Adding a solvent, a plasticizer, a film forming agent, a tackifier and a bacteriostatic agent into a reaction container in sequence, and stirring at a low speed of 50rpm for 5 hours at a temperature of 50 ℃ to form uniform gel;

2) standing or vacuumizing for a short time to remove bubbles, and filling to obtain the liquid dressing product when the bubbles disappear.

Example 2: taking the configuration 100g as an example, take by weight:

polyvinyl alcohol 3g

Polyvinyl butyral 3g

Phenolic resin 2g

Ethyl acetate 5g

Rosin 3g

Castor oil 2g

Glycerol 2g

Phenoxyethanol 1g

Isopropanol 29g

50g of absolute ethyl alcohol

1) Adding a solvent, a plasticizer, a film forming agent, a tackifier and a bacteriostatic agent into a reaction container in sequence, and stirring at a low speed of 70rpm for 3 hours at a temperature of 60 ℃ to form uniform gel;

Example 3: taking the configuration 100g as an example, take by weight:

polyvinyl alcohol 4g

Polyvinyl butyral 6g

Polyacrylic resin 3g

Rosin 3g

Castor oil 2g

Dibutyl phthalate 2g

Glycerol 3g

Chlorophytidine 1.5g

Phenoxyethanol 0.5g

Isopropanol 25g

50g of absolute ethyl alcohol

1) Adding a solvent, a plasticizer, a film forming agent, a tackifier and a bacteriostatic agent into a reaction container in sequence, and stirring at a low speed of 70rpm for 3 hours at a temperature of 65 ℃ to form uniform gel;

Example 4: taking the configuration 100g as an example, take by weight:

polyvinyl alcohol 8g

Polyvinyl butyral 8g

Phenolic resin 0.5g

Ethyl acetate 1g

Propylene glycol 2g

Rosin 2g

Castor oil 3g

Ethyl paraben 1g

Chlorophytidine 0.5g

Isopropanol 39g

35g of anhydrous ethanol

1) Adding a solvent, a plasticizer, a film forming agent, a tackifier and a bacteriostatic agent into a reaction container in sequence, and stirring at a low speed of 70rpm for 2 hours at a temperature of 70 ℃ to form uniform gel;

Examples of the experiments

Experimental example 1 measurement of film Forming time

The film forming time after the dressing is coated is not more than 3 min. Taking a certain amount of liquid dressing, coating the liquid dressing on a flat plate, starting timing, wherein the coating thickness is 0.5mm, the coating area is about 2cm multiplied by 3cm =6cm2, timing is finished after the liquid dressing is volatilized to form a film, and the film forming time is calculated.

The test samples were the liquid dressing samples 1, 2, 3 and 4 prepared according to examples 1, 2, 3 and 4, respectively. And commercially available forest, New Skin, and one-time smear film formation times were measured, three times for each sample. The result shows that the film forming time of the samples 1-4 is shorter than that of other liquid band-aids sold in the market.

TABLE 1 film formation time test results

Experimental example 2 air permeability measurement

The air permeability of the first layer coated with the dressing is not less than 300g/m²And 24 h. The water vapor transmission rate of the film formed by applying the first layer of the dressing was tested according to the method specified in YY/T0471.2-2004, and the applied thickness was about 0.5mm and the area was about 6cm by 6cm =36cm²Each sample was subjected to 3 experiments. The result shows that the air permeability is qualified, and the air permeability effect is better than that of similar products.

TABLE 2 air permeability test results

Experimental example 3 measurement of stretchability

The curing dressing is stretched by 20 percent, and the maximum load is less than or equal to 7.0N/cm. Applying a certain amount of liquid dressing on a flat plate, wherein the application size is 2cm × 4cm =8cm²After the film was evaporated to a film, the film was peeled off for stretchability testing according to YY/T0471.4-2004 contact wound dressing test method part 4 for comfort. Each sample was tested 3 times and the results showed that examples 1-4 passed, the Xiaolin and New Skin failed and the extensibility passed.

TABLE 3 extensibility test results

Experimental example 4 Water repellency measurement

The membrane is not dissolved for more than 10 hours after soaking in water. Taking a certain amount of liquid dressing, smearing the liquid dressing on a flat plate, putting the flat plate in water for 10h after the liquid dressing is volatilized to form a film, and taking out for observation. The results show that the water repellency was acceptable.

TABLE 4 results of Water repellency test

Experimental example 5 pH measurement

The pH range is 5.5-7.5. The pH was measured according to the method of measuring pH of 0631 in the fourth part of the "Chinese pharmacopoeia" 2015 edition. The results show that the pH values are in accordance with the specification.

Experimental example 6 determination of heavy Metal content

The heavy metal content of the dressing is not more than 20 mu g/g. According to a GB/T14233.1-2008 medical transfusion, blood transfusion and injection apparatus test method, a first part is as follows: chemical analysis methods were used for the tests. The results show that the heavy metal content meets the specifications.

Experimental example 7 initial contamination determination

The initial contamination bacteria number of the dressing is less than or equal to 100 cfu/g. According to the provisions of appendix C of GB/T15980. The results show that the initial contaminating bacteria meet the specifications.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. A waterproof wound-protecting liquid dressing is prepared from filming agent (6-16 wt.%), tackifier (0.5-3), plasticizer (3-12), bacteriostatic agent (0.5-2) and solvent (67-90) through adding all the components to reactor, heating while stirring to form uniform gel, vacuumizing to remove air bubbles, and loading.

2. The liquid dressing of claim 1, wherein the film-forming agent is a mixture of polyvinyl alcohol and polyvinyl butyral at a ratio of 0.5-1.0.

3. The liquid dressing of claim 1, wherein the adhesion promoter is one of a phenolic resin and an acrylic resin.

4. The liquid dressing of claim 1, wherein the plasticizer is a mixture of two or more of diethyl/butyl phthalate, ethyl acetate, glycerol, propylene glycol, rosin and castor oil.

5. The liquid dressing of claim 1, wherein the bacteriostatic agent is one or more of ethylparaben, phenoxyethanol and chlorphenesin.

6. The liquid dressing of claim 1, wherein the solvent is one or a mixture of isopropyl alcohol and absolute ethyl alcohol, and the mixing ratio of isopropyl alcohol to absolute ethyl alcohol is 0.5-1.0.

7. A method of making a liquid dressing according to claim 1, comprising the steps of:

8. The method for preparing a liquid dressing for preventing water and wounds according to claim 7, wherein the packaging is selected from a packaging tube or bottle with high sealing performance, preferably a cut-off coating type packaging tube, a bottle with brush or sheet, a vacuum bottle and the like.