CN103285418A - Novel biological antibacterial dressing aerosol based on large-area burn wound - Google Patents
Novel biological antibacterial dressing aerosol based on large-area burn wound Download PDFInfo
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- CN103285418A CN103285418A CN2013102386717A CN201310238671A CN103285418A CN 103285418 A CN103285418 A CN 103285418A CN 2013102386717 A CN2013102386717 A CN 2013102386717A CN 201310238671 A CN201310238671 A CN 201310238671A CN 103285418 A CN103285418 A CN 103285418A
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- antibacterial dressing
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Abstract
The invention relates to novel biological antibacterial dressing aerosol based on a large-area burn wound. The novel biological antibacterial dressing aerosol is produced by placing biological antibacterial dressing and compressed gas nitrogen taken as a propellant into an aerosol pot together, wherein the biological antibacterial dressing comprises chitosan, acetic acid, lysozyme and nano pearl powder. According to the biological antibacterial dressing aerosol, the drug is evenly sprayed on the surface of burns, and a layer of protective film is formed on the wound, so that the novel biological antibacterial dressing aerosol has the functions of preventing and treating wound infection, promoting wound healing and inhibiting the growth of scars, the function of quickly killing clinical common bacteria on the burns, and a very good sterilization effect, does not have toxic or side effects to a human body, and is less prone to drug resistance.
Description
Technical field
The present invention relates to a kind of new bio antiseptic dressing aerosol that the large-area burns wound surface is used for the treatment of, particularly a kind of natural biological pharmaceutical aerosol agent formulation that contains the treatment burn of chitosan.
Background technology
Burn is a kind of common exogenous injury of human body, and burn not only causes the damage of skin, and can cause serious systemic reaction, and especially large-area burns, general reaction are particularly violent, so early stage correct processing of burn wound is the key measure of protecting from infection.
In order to control courses of infection, human invention is also used antibiotic.Present antibiotic effect has been subjected to the huge challenge of problems such as drug resistance, toxic and side effects and cure rate are more and more lower.Therefore seek natural biomaterial, developing direction and trend that to study safe and effective biological function dressing be this field.
When wound surface occurred, body's immunity descended, and Nutrition and Metabolism and microcirculation are unbalance, a large amount of tissue fluids are detained or are oozed out, and arginine concentration sharply descends a large amount of negative charges of wound surface enrichment in the part of wound surface and blood, wound very easily infects simultaneously, and it is very slow that wound healing becomes.So, wound healing not only need antiinflammatory, antibacterial, protect from infection, and need to replenish more other material of overlying tissue of necessary nutrient substance and structure.
At present clinically, for the large-area burns wound surface, need the repeated multiple times debridement to change dressings when adopting plaster treatment, big and increase the weight of the patient suffering to the wound surface zest, cause healing slow, infect easily, can't normally recover, and easily cause multiple complications.
The objective of the invention is to overcome the shortcoming and defect of above-mentioned prior art, develop a kind of new bio antiseptic dressing aerosol, be used for the treatment of large-area burns.
Summary of the invention
The technical issues that need to address of the present invention are based on the new bio antiseptic dressing aerosol that the large-area burns wound surface is used, overcome the deficiency that prior art exists, need not any chemicals and antibiotic prerequisite under, can realize quick sterilization, lasting sterilization again, and provide suitable nutritional support, accelerating wound, the wound surface cicatrix that alleviates.
Technical scheme of the present invention:
Biological antibacterial dressing aerosol of the present invention comprises:
(1) the biological antibacterial dressing compositions of the fluid form for the treatment of effective dose adds the biological antibacterial dressing compositions in the aerosol container aerosol container of more an amount of Compressed Gas nitrogen being packed into earlier during its preparation.
Described biological antibacterial dressing compositions contains:
(a) chitosan: 0.1～10%,
(b) acetic acid: 0.1～2%,
(c) lysozyme: 0.1～5%,
(d) nanometer Margarita powder: 0.02～5 %,
(e) water: 0～99.86%;
(f) Compressed Gas nitrogen;
Above-mentioned lysozyme is a kind of in staphylococcus lysozyme, endogenous or the exogenous lysozyme or their compound enzyme.
Said chitosan is the derivant of chitin after refining, deacetylated, and its technology of preparing is reported in about " the preferred research of chitosan production technology " document in that Marine University Of Zhanjiang's journal the 17th volume the 2nd is interim.Be summarized as follows:
Say that chitin is immersed in the hydrochloric acid solution of 1.9mol/L, be warming up to 65 ℃-70 ℃ and kept 1 to 1.5 hour that reaching the degraded critical point at it is to take out.After the flush away acid solution, immerse in the sodium hydroxide solution of 2.5mol/L, be warming up to 70 ℃ to 75 ℃ and kept 2.5 to 3 hours, behind the flush away alkali liquor, using distilled water drip washing 2 to 3 times and pressure sterilizing, the chitosan that can obtain to address.
Above-mentioned biological antibacterial dressing aerosol prepares by the following method:
Behind distilled water, acetate dissolution chitosan, under 50-55 ℃ of temperature, nitrogen protection, add lysozyme, nanometer Margarita powder in proportion, stir preparation 4-8 hour, filter, obtain described biological dressing; Then this biological antibacterial dressing and Compressed Gas nitrogen are together inserted aerosol container, namely make the new bio antiseptic dressing aerosol that a kind of large-area burns wound surface is used.
Foundation of the present invention: adopt raw materials such as chitosan and lysozyme, by chitosan combination degradation technique, make chitosan, degradation of chitosan product and lysozyme three reach Synergistic biocidal potentiation purpose; Utilize preserving moisture and film forming characteristics of chitosan, and the nutritional support that provides of nanometer Margarita powder, further promote wound healing and suppress the cicatrix growth.Utilize lysozyme degradation technique and nitrogen protection, suppress the oxidation of product in preparation process, keep the activity of biomaterial.
Chitosan has hemostasis and promotes the effect of wound healing, and good film-forming property, and its film is easily combined closely with wound surface, is used for burn, not only can avoid bacterial infection, and can breathe freely, and absorbs the transudate of wound, slows down pain, the promotion wound healing.
Lysozyme has very strong sterilizing ability, can cut off glycine peptide bond in the malignant bacteria whole cell peptidoglycan composition (GLY-GLY key) rapidly, sterilization rapidly, and make the cell polar difficulty produce drug resistance to it.
Margarita powder has the promoting tissue regeneration and ulcer healing effect, aminoacid in the Margarita powder and trace element provide the prescribing adequate nutrition environment for the wound surface Skin Cell, the specific surface area of nanometer Margarita powder increases simultaneously, wherein the dissolubility of slightly solubility composition and dissolution velocity obviously increase, its concentration of liquid outside Skin Cell is significantly improved, can further promote wound healing and suppress the growth of wound surface cicatrix of skin.
This biological antibacterial dressing adopts the atomizing design; form administration with aerosol; medicinal liquid can be sprayed directly on to wound surface; easy to use; not limited by area, position; do not influence normal activity, the more important thing is and avoid smearing, wipe the pain and the wound surface that cause when changing dressings and damage again, be beneficial to the faster recovery of wound surface.
The present invention with nitrogen as Compressed Gas; on the one hand as the impelling carrier of biological antibiotic fluid dressing, fluid dressing is contained in and adopts nitrogen protection in the hermetic container on the other hand, can avoid and the contacting of air, light; suppress oxidation and the degraded of product, improve the stability of product.
Therefore, when this biological antibacterial dressing aerosol is sprayed onto wound, can kill the various common clinical bacterium of wound fast, and drug resistance golden staphylococci, multidrug resistant bacillus pyocyaneus are had specially good effect, solve the dressing field and used antibiotics easily to produce the problem of Resistant strain; Form layer protecting film at wound surface simultaneously, have the control traumatic infection, promote wound healing and suppress cicatrix growth effect.
The specific embodiment
By following embodiment the specific embodiment of the present invention is described, but protection scope of the present invention is not limited to this.
Embodiment 1-7
According to following ratio preparation biological antibacterial dressing
Embodiment
| ? | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| Chitosan | 0.1 | 0.2 | 0.4 | 0.6 | 0.8 | 1.0 | 1.2 |
| Lysozyme | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
| Nanometer Margarita powder | 0.2 | 0.2 | 0.5 | 0.5 | 0.5 | 2 | 1 |
The biological antibacterial dressing of above-described embodiment to the sterilizing rate of escherichia coli, bacillus pyocyaneus, golden staphylococci, Candida albicans all greater than 90%.
Claims (3)
1. biological antibacterial dressing aerosol, it is characterized in that, the biological antibacterial dressing compositions and the Compressed Gas nitrogen that comprise the fluid form for the treatment of effective dose, earlier the biological antibacterial dressing compositions is added in the aerosol container during its preparation, an amount of Compressed Gas nitrogen is packed in the aerosol container, wherein the biological antibacterial dressing compositions contains again:
(a) chitosan: 0.1～10%,
(b) acetic acid: 0. 1～2%,
(c) lysozyme: 0. 1～5%,
(d) nanometer Margarita powder: 0.02～5%,
(e) water: 78～99.68%.
2. biological antibacterial dressing aerosol as claimed in claim 1 is characterized in that, above-mentioned lysozyme is a kind of or their compound enzyme of staphylococcus lysozyme, endogenous or exogenous lysozyme.
3. biological antibacterial dressing aerosol as claimed in claim 1, it is characterized in that, its preparation method comprises the steps: with behind distilled water, the acetate dissolution chitosan, under 50-70 ℃ of temperature, nitrogen protection, add lysozyme, nanometer Margarita powder in proportion, stir preparation 4-8 hour, filter, obtain described biological antibacterial dressing; Then this biological antibacterial dressing and Compressed Gas nitrogen are inserted in the aerosol container, namely make the new bio antiseptic dressing aerosol that a kind of large-area burns wound surface is used.
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| CN2013102386717A CN103285418A (en) | 2013-06-17 | 2013-06-17 | Novel biological antibacterial dressing aerosol based on large-area burn wound |
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| CN2013102386717A CN103285418A (en) | 2013-06-17 | 2013-06-17 | Novel biological antibacterial dressing aerosol based on large-area burn wound |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796466A (en) * | 2016-05-20 | 2016-07-27 | 中山市天图精细化工有限公司 | Pearl powder aerosol |
| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364646A (en) * | 2002-01-21 | 2002-08-21 | 徐云龙 | Biological dressing and its preparing method |
| CN1732896A (en) * | 2004-08-12 | 2006-02-15 | 浙江山下湖珍珠集团股份有限公司 | Nanometer pearl spray and method for preparing the same |
| CN102113540A (en) * | 2011-01-28 | 2011-07-06 | 上海海洋大学 | Composite biological preservative for refrigerating trichiurus haumela and preparation method thereof |
-
2013
- 2013-06-17 CN CN2013102386717A patent/CN103285418A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1364646A (en) * | 2002-01-21 | 2002-08-21 | 徐云龙 | Biological dressing and its preparing method |
| CN1732896A (en) * | 2004-08-12 | 2006-02-15 | 浙江山下湖珍珠集团股份有限公司 | Nanometer pearl spray and method for preparing the same |
| CN102113540A (en) * | 2011-01-28 | 2011-07-06 | 上海海洋大学 | Composite biological preservative for refrigerating trichiurus haumela and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796466A (en) * | 2016-05-20 | 2016-07-27 | 中山市天图精细化工有限公司 | Pearl powder aerosol |
| CN105796466B (en) * | 2016-05-20 | 2019-02-01 | 中山市天图精细化工有限公司 | A kind of pearl powder aerosol |
| CN109675091A (en) * | 2019-01-26 | 2019-04-26 | 湖南博隽生物医药有限公司 | A kind of biological dressing and preparation method thereof for eliminating scar |
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Application publication date: 20130911 |