CN107617121B - Biological induction active dressing for skin wound surface and preparation method and application thereof - Google Patents
Biological induction active dressing for skin wound surface and preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medical materials, and particularly relates to a skin wound biological induction active dressing, and a preparation method and application thereof. The invention relates to a biological induction active dressing for skin wound surfaces, which comprises the following components in parts by weight: 18-22 parts of chitosan polymer, 30-50 parts of sodium alginate, 5-9 parts of sodium phenytoin, 12-18 parts of strontium-doped borate bioactive glass, 5-10 parts of spirulina powder, 16-22 parts of ethanol, 13-17 parts of glycerol and 300 parts of water for injection 200-. The biological induction active dressing for the skin wound surface provided by the invention has scientific and reasonable compatibility, the components interact with each other, an optimum environment is provided for the growth and healing of the wound, and the biological induction active dressing has obvious antibacterial, anti-inflammatory and analgesic effects.
Description
Technical Field
The invention belongs to the technical field of medical materials, and particularly relates to a skin wound biological induction active dressing, and a preparation method and application thereof.
Background
The medical dressing is a medical material which is covered on a wound and has the functions of temporary protection, infection prevention and healing promotion on the wound. Human skin is a barrier to maintain the internal environment stable and prevent the invasion of microorganisms, skin wounds due to ulcers, burns, etc. cause a series of problems such as infection, loss of moisture, and dysfunction of the immune system, and dressings generally provide a good environment for wound repair by absorbing exudates, keeping the wound surface moist, and preventing bacterial contamination of wounds and new tissue growth.
The traditional dressings commonly used in clinic such as various gauzes, cotton pads and the like are mostly processed from cotton, linen and linen, although the traditional dressings are wide in source, low in cost and simple to manufacture, have no obvious promotion effect on wound healing, are rough and dry in surface and easy to rub to cause further damage to the wound, granulation tissues growing on the wound easily grow into meshes of the dressings, the dressings are easily pulled to cause pain and damage to the wound when the dressings are changed, the traditional gauzes are poor in water absorption, patients with more wound exudation often need to be changed for many times, the clinical workload is increased, dressing fibers are also easy to fall off, and foreign body reaction is caused. With the continuous and intensive research on the pathophysiological mechanism in the wound healing process, people realize that the purpose of using the dressing is not only to cover the wound surface and prevent bleeding and infection, but also that the ideal dressing can have the effect of promoting wound healing. Therefore, in order to protect the wound surface and promote the wound healing more effectively, a plurality of dressings are added with components such as medicines or epidermal growth factors, and the like, thereby becoming functional dressings.
Chinese patent application 105854069A discloses an alginate dressing containing a drug for promoting wound healing and a preparation method thereof, wherein the alginate dressing comprises the following components: 50-99.9 parts of alginate, 0.1-25 parts of a drug for promoting wound healing and 0.01-15 parts of a surfactant; the alginate dressing containing the medicine for promoting wound healing can be used for wound surfaces with difficult healing and tissue defect wound surfaces, absorbs exudates, provides a wet environment required by wound surface healing, can effectively promote wound healing, but the effect of promoting wound healing needs to be improved.
The Chinese patent application CN105079858A discloses a wound sterilization and repair liquid dressing and a preparation method thereof, wherein the wound sterilization and repair liquid dressing is a double-emulsion system solution with sterilization and repair functions, which is formed by taking water-soluble aminopolysaccharide, a sterilization preservative and a high-molecular polymer sterilization disinfectant as main active ingredients and taking a high-molecular emulsifier as an emulsifier, can promote wound healing, resist exudation, inhibit bacteria and prevent infection, and is suitable for the washing or wet dressing treatment of related wounds such as burn, scald, incised wound, chronic infection wound and the like. However, the liquid dressing is usually in a liquid state, has poor stability and inconvenient use process, and cannot meet the use requirements of people.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a biological induction active dressing for skin wound surfaces, and a preparation method and application thereof. The biological induction active dressing for the skin wound surface provided by the invention has the advantages of scientific and reasonable compatibility, convenient use and obvious effects of diminishing inflammation, resisting bacteria and promoting wound surface healing.
The invention provides a biological induction active dressing for skin wound surfaces, which comprises the following components in parts by weight:
18-22 parts of chitosan polymer, 30-50 parts of sodium alginate, 5-9 parts of sodium phenytoin, 12-18 parts of strontium-doped borate bioactive glass, 5-10 parts of spirulina powder, 16-22 parts of ethanol, 13-17 parts of glycerol and 300 parts of water for injection 200-.
Further, the skin wound biological induction active dressing comprises the following components in parts by weight:
20 parts of chitosan polymer, 40 parts of sodium alginate, 7 parts of phenytoin sodium, 15 parts of strontium-doped borate bioactive glass, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerol and 250 parts of water for injection.
Further, the chitosan polymer is composed of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 2-4: 1-3.
Further, the chitosan polymer is composed of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 3: 2.
Furthermore, the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22:18:32:2: 4.
further, the grain size of the strontium-doped borate bioactive glass is less than 10 μm.
In addition, the invention also provides a preparation method of the skin wound biological induction active dressing, which comprises the following steps:
s1, taking half amount of water for injection, adding chitosan polymer, fully stirring, adding phenytoin sodium and spirulina powder, uniformly stirring, removing bubbles, transferring to a sterilization tank, and performing sterilization treatment to obtain a mixture A;
s2, adding sodium alginate into the mixed solution of glycerol and ethanol, stirring uniformly, adding the rest of water for injection, and stirring fully to obtain a mixture B;
s3, uniformly mixing the mixture A obtained in the step S1, the mixture B obtained in the step S2 and the strontium-doped borate bioactive glass, removing bubbles, paving a film, drying, sterilizing in a sterilizing tank, and packaging to obtain the strontium-doped borate bioactive glass.
Further, the sterilization temperature in the steps S1 and S3 is 115-135 ℃.
The invention also requests to protect the application of the skin wound biological induction active dressing in promoting wound healing.
The chitosan polymer material has the performances of moisture absorption, moisture preservation, bacteriostasis, hemostasis and the like, the dressing disclosed by the invention utilizes the chitosan polymer compounded by carboxymethyl chitosan and chitosan hydrochloride to synergistically play the effects of bacteriostasis, inflammation diminishing and pain relieving with the components of spirulina powder, phenytoin sodium and the like, and tests show that the skin wound surface biological induction active dressing disclosed by the invention has a remarkable inhibiting effect on staphylococcus aureus, beta hemolytic streptococcus, pseudomonas aeruginosa and candida albicans; anti-inflammatory tests show that compared with a control group, the skin wound biological induction active dressing prepared by the invention can obviously reduce the ear weight difference of mice, has a better anti-inflammatory effect, and has an anti-inflammatory effect superior to that of compound dexamethasone emulsifiable paste. In addition, the strontium-doped borate bioactive glass with good biodegradability and bioactivity is added to the skin wound biological induction active dressing as a carrier, so that on one hand, the release speed of active ingredients in the dressing can be controlled, on the other hand, platelets and plasma can be well adsorbed in the dressing, the generation of growth factors is promoted, the proliferation capacity of cells is improved, the growth of granulation tissues and epithelial tissues is promoted, and the healing of the wound is facilitated.
Compared with the prior art, the invention has the technical advantages that:
(1) the biological induced active dressing for the skin wound surface has the effects of bacteriostasis, inflammation diminishing and pain easing, and can effectively relieve the pain of patients. (2) The biological induction active dressing for the skin wound surface is convenient to use, has strong capability of absorbing exudates, does not adhere to the wound, and has strong moisturizing performance. (3) The biological induction active dressing for the skin wound has a good effect of promoting wound healing, wherein the fastest healing time is 13 days.
Detailed Description
The present invention is further described in the following description of the specific embodiments, which is not intended to limit the invention, but various modifications and improvements can be made by those skilled in the art according to the basic idea of the invention, within the scope of the invention, as long as they do not depart from the basic idea of the invention.
In the invention, the strontium-doped borate bioactive glass is purchased from Schottky (Shanghai) precision materials and equipment International trade company; carboxymethyl chitosan CAS: 83512-85-0; chitosan hydrochloride CAS: 70694-72-3; sodium alginate CAS: 630-93-3; spirulina powder CAS: 724424-92-4.
Example 1A dressing with biological inducing activity for skin wound surface
The skin wound biological induction active dressing comprises the following components in parts by weight:
18 parts of chitosan polymer, 50 parts of sodium alginate, 9 parts of phenytoin sodium, 12 parts of strontium-doped borate bioactive glass, 10 parts of spirulina powder, 22 parts of ethanol, 13 parts of glycerol and 200 parts of water for injection; the chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 2: 1; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22:18:32:2: 4.
the preparation method comprises the following steps:
s1, taking half amount of water for injection, adding chitosan polymer, fully stirring, adding phenytoin sodium and spirulina powder, uniformly stirring, removing bubbles, transferring to a sterilization tank at 115 ℃ for sterilization treatment, and obtaining a mixture A;
s2, adding sodium alginate into the mixed solution of glycerol and ethanol, stirring uniformly, adding the rest of water for injection, and stirring fully to obtain a mixture B;
s3, uniformly mixing the mixture A obtained in the step S1, the mixture B obtained in the step S2 and the strontium-doped borate bioactive glass, degassing, spreading a film, drying, sterilizing in a sterilizing tank at 115 ℃, and packaging to obtain the strontium-doped borate bioactive glass.
Example 2A dressing with biological inducing activity for skin wound surface
The skin wound biological induction active dressing comprises the following components in parts by weight:
20 parts of chitosan polymer, 40 parts of sodium alginate, 7 parts of phenytoin sodium, 15 parts of strontium-doped borate bioactive glass, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerol and 250 parts of water for injection. The chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 3: 2; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22:18:32:2: 4.
the preparation method comprises the following steps:
s1, adding a half amount of water for injection into chitosan polymer, stirring, adding phenytoin sodium and spirulina powder, stirring uniformly, degassing, transferring to a 125 ℃ sterilization tank, and sterilizing to obtain a mixture A;
s2, adding sodium alginate into the mixed solution of glycerol and ethanol, stirring uniformly, adding the rest of water for injection, and stirring fully to obtain a mixture B;
s3, uniformly mixing the mixture A obtained in the step S1, the mixture B obtained in the step S2 and the strontium-doped borate bioactive glass, degassing, spreading a film, drying, sterilizing in a sterilization tank at 125 ℃, and packaging to obtain the strontium-doped borate bioactive glass.
Example 3A dressing with biological inducing activity for skin wound surface
The skin wound biological induction active dressing comprises the following components in parts by weight:
22 parts of chitosan polymer, 30 parts of sodium alginate, 5 parts of phenytoin sodium, 18 parts of strontium-doped borate bioactive glass, 5 parts of spirulina powder, 16 parts of ethanol, 17 parts of glycerol and 300 parts of water for injection; the chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 4: 3; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22:18:32:2: 4.
the preparation method comprises the following steps:
s1, adding a half amount of water for injection into chitosan polymer, stirring, adding phenytoin sodium and spirulina powder, stirring uniformly, removing bubbles, transferring to a sterilization tank at 135 ℃ for sterilization to obtain a mixture A;
s2, adding sodium alginate into the mixed solution of glycerol and ethanol, stirring uniformly, adding the rest of water for injection, and stirring fully to obtain a mixture B;
s3, uniformly mixing the mixture A obtained in the step S1, the mixture B obtained in the step S2 and the strontium-doped borate bioactive glass, removing bubbles, paving a film, drying, sterilizing in a sterilization tank at 135 ℃, and packaging to obtain the strontium-doped borate bioactive glass.
Comparative example 1 biological induction active dressing for skin wound surface
The skin wound biological induction active dressing comprises the following components in parts by weight:
20 parts of chitosan polymer, 40 parts of sodium alginate, 7 parts of phenytoin sodium, 15 parts of strontium-doped borate bioactive glass, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerol and 250 parts of water for injection; the chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 1: 1; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22:18:32:2: 4.
the preparation method is similar to example 2.
The difference from example 2 is that the chitosan-based polymer consists of carboxymethyl chitosan and chitosan hydrochloride in a weight ratio of 1: 1.
Comparative example 2 biological induction active dressing for skin wound surface
The skin wound biological induction active dressing comprises the following components in parts by weight:
20 parts of chitosan polymer, 40 parts of sodium alginate, 7 parts of phenytoin sodium, 15 parts of strontium-doped borate bioactive glass, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerol and 250 parts of water for injection; the chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 3: 2; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22: 20: 32:2: 2.
the preparation method is similar to example 2.
The difference from the example 2 is that the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, the molar ratio of each component is 6:8:8:22: 20: 32:2: 2, i.e. increase B2O3The molar fraction of SrO is reduced.
Test example I, in vitro bacteriostatic test of dressing with skin wound biological induction activity
1. Test materials: the skin wound biological induction active dressings prepared in examples 1-3 and comparative examples 1-2 of the present invention.
2. The test method comprises the following steps:
preparing test bacterial liquid: respectively inoculating staphylococcus aureus, beta hemolytic streptococcus, pseudomonas aeruginosa and candida albicans into a beef extract culture solution in a sterile operating room, and performing conventional culture at the temperature of 28-30 ℃.
Adopting agar perforation diffusion method, dividing the aseptic culture dish into 5 groups, each group comprises 4, pouring 15-20mL of sterilized beef extract culture solution into each aseptic culture dish, sucking 0.1mL of test bacteria solution of staphylococcus aureus, beta hemolytic streptococcus, pseudomonas aeruginosa and candida albicans by an aseptic pipette after the beef extract culture solution is solidified, adding the test bacteria solution onto the culture dish, uniformly coating, and adding different strains into each culture dish in each group.
After the coating, the culture medium was perforated with 5 holes at equal intervals using a sterilized stainless steel punch having an outer diameter of 4 mm. The dressings prepared in examples 1 to 3 and comparative examples 1 to 2 were completely dissolved in sterile water, 30. mu.l of the solutions of the dressings prepared in examples 1 to 3 and comparative examples 1 to 2 were respectively sucked by a microsyringe, and an equivalent amount of physiological saline was added to one well of the center of the solution to prepare a control group and labeled. Culturing the bacteria at 38 deg.C for 24h, measuring the diameter of inhibition zone (measured by inhibition diameter mm), repeating the test for 3 times, and taking the average value.
3. And (3) test results: the test results are shown in table 1.
TABLE 1 bacteriostatic test data for skin wound bio-induced active dressing
As can be seen from Table 1, the bacteriostatic diameter of the skin wound biological induction active dressing prepared by the invention on staphylococcus aureus is larger than 23.8mm, the bacteriostatic diameter on beta hemolytic streptococcus is larger than 32.1mm, the bacteriostatic diameter on pseudomonas aeruginosa is larger than 34.1mm, and the bacteriostatic diameter on white staphylococcus is larger than 30.3mm, namely, the dressing has obvious inhibitory action on staphylococcus aureus, beta hemolytic streptococcus, pseudomonas aeruginosa and white candida, and the bacteriostatic effect of the skin wound biological induction active dressing in the comparative examples 1-2 is obviously different from that of the dressing in the examples 1-3, so that the dressing has scientific and reasonable compatibility of components and better bacteriostatic action.
Test example two, anti-inflammatory test of dressing with skin wound biological induction activity
1. Test subjects: 60 male mice of Kunming species, weighing 40-50 g.
2. Test materials: the skin wound biological induction active dressing and the compound dexamethasone emulsifiable paste prepared in the embodiments 1 to 3 and the comparative example 1 of the invention are purchased from Jilin labor-saving peptide pharmaceutical Co., Ltd, and are in a Chinese medicine standard H84202427.
3. The test method comprises the following steps:
the method comprises the following steps of randomly dividing 60 mice into 6 groups, wherein each group comprises 10 mice, namely a control group, a dexamethasone group, examples 1-3 groups and a comparative example 1 group, uniformly coating 50 mu l of dimethylbenzene on the right ear of each group of mice, using the left ear as a control, and coating the right ear of each group of mice with the following medicaments after 2h of inflammation:
control group: smearing normal saline; dexamethasone group: smearing compound dexamethasone emulsifiable paste; example 1 group: smearing 1g/ml of the skin wound biological induction active dressing prepared in the example 1; example 2 group: smearing 1g/ml of the skin wound biological induction active dressing prepared in the example 2; example 3 group: smearing 1g/ml of the skin wound biological induction active dressing prepared in the example 3; comparative example 1 group: 1g/ml of the biological induction active dressing for the skin wound surface prepared in the comparative example 1 is smeared.
And (3) removing the vertebra after the medicine is applied for 10 hours, killing the patient, cutting two ears along the auricle, punching round ear pieces on the same parts of the left ear and the right ear by using an 8mm puncher, weighing, and calculating the ear weight difference, wherein the ear weight difference is equal to the weight of the round ear piece of the right ear and the weight of the round ear piece of the left ear.
4. And (3) test results: the test results are shown in table 2.
TABLE 2 influence of biologically induced active dressing on mouse otoxin xylene-induced swelling of skin wounds
| Group of | N/only | Ear weight difference/mg |
| Control group | 10 | 8.21±1.23 |
| Dexamethasone group | 10 | 5.13±0.52** |
| EXAMPLE 1 group | 10 | 4.42±0.95**a |
| EXAMPLE 2 group | 10 | 3.98±0.76**a |
| EXAMPLE 3 group | 10 | 4.36±0.68**a |
| Comparative example 1 group | 10 | 5.41±1.12** |
Note: there was a very significant difference (P < 0.01) compared to the control group; a is significantly different from the group of the comparative example 1 (P < 0.05).
As can be seen from Table 2, compared with the control group, the groups of examples 1 to 3 can significantly reduce the ear weight difference of mice, have better anti-inflammatory effect, and the anti-inflammatory effect is better than that of the compound dexamethasone cream, wherein the best effect of example 2 is the best embodiment of the invention; compared with the comparative example 1, the anti-inflammatory effect of the dressing with skin wound biological induction activity prepared in the embodiment 2 of the invention has significant difference, which shows that the chitosan polymer compounded by carboxymethyl chitosan and chitosan hydrochloride and each component are mutually synergistic and have significant anti-inflammatory effect.
Test example III test for promoting wound healing by using skin wound biological induction active dressing
1. Test subjects: 50 male mice of Kunming species, weighing 40-50 g.
2. Test materials: the skin wound biological induction active dressing prepared in the examples 1-3 of the invention is the same as the skin wound dressing (except that the strontium-doped borate biological active glass is not contained, the rest is the same as the example 2).
3. The test method comprises the following steps:
50 mice were randomly divided into 5 groups of 10 mice each, control group, skin wound dressing group, and examples 1-3 groups. After the abdominal injection anesthesia of 5 groups of rats, mechanical full-layer skin wound surfaces with the diameter of 2cm and the depth and subcutaneous muscle fascia are manufactured on the two sides of the back, the hemostasis is performed by sterile gauze, and the medicine coating process is as follows:
the control group is loaded into gauze by 0.5mL of physiological saline to cover the wound surface; the example 1-3 groups and the skin wound dressing group were each coated with the prepared dressing and replaced every other day.
Wound healing rates were determined at 5d and 10d, where wound healing rate is (initial wound area-non-healed wound area)/initial wound area × 100%. And recording the wound healing time, wherein the wound healing time is one of traditional indexes for evaluating wound healing and is defined as the time required by complete epithelialization of the wound, and the epithelialization depends on visual observation.
4. And (3) test results: the test results are shown in table 3.
TABLE 3 mouse wound healing
Note: significant difference (P < 0.05) compared to control group; there was a very significant difference (P < 0.01) compared to the control group; a is obviously different from the skin wound dressing group (P is less than 0.05); aa is very different from the skin wound dressing group (P is less than 0.01).
As can be seen from Table 3, the dressing prepared by the invention has a remarkable effect of promoting wound healing. Compared with a control group, the wound healing rate of a mouse using the skin wound biological induction active dressing is higher, the healing time is short, wherein the best effect is obtained in example 2, and the healing time is 13 days, which is the best example of the invention; compared with a skin wound dressing group, the skin wound biological induction active dressing prepared in the embodiment 2 of the invention has significance in promoting the healing of the mouse wound, which shows that the formula of the skin wound biological induction active dressing prepared in the invention is reasonable, and the strontium-doped borate biological induction active glass has obvious effect of promoting the healing of the wound.
Claims (5)
1. The biological induction active dressing for the skin wound surface is characterized by comprising the following components in parts by weight:
20 parts of chitosan polymer, 40 parts of sodium alginate, 7 parts of phenytoin sodium, 15 parts of strontium-doped borate bioactive glass, 8 parts of spirulina powder, 19 parts of ethanol, 15 parts of glycerol and 250 parts of water for injection;
the chitosan polymer consists of carboxymethyl chitosan and chitosan hydrochloride according to the weight ratio of 3: 2; the chemical component of the strontium-doped borate bioactive glass is Na2O-K2O-MgO-CaO-B2O3-SiO2-P2O5SrO, and the molar ratio of the components is 6:8:8:22:18:32:2: 4.
2. A wound bio-inducing active dressing according to claim 1, wherein the particle size of the strontium doped borate bioactive glass is less than 10 μm.
3. A method of preparing a dressing having skin wound biological inducing activity according to any one of claims 1-2, comprising the steps of:
s1, taking half amount of water for injection, adding chitosan polymer, fully stirring, adding phenytoin sodium and spirulina powder, uniformly stirring, removing bubbles, transferring to a sterilization tank, and performing sterilization treatment to obtain a mixture A;
s2, adding sodium alginate into the mixed solution of glycerol and ethanol, stirring uniformly, adding the rest of water for injection, and stirring fully to obtain a mixture B;
s3, uniformly mixing the mixture A obtained in the step S1, the mixture B obtained in the step S2 and the strontium-doped borate bioactive glass, removing bubbles, paving a film, drying, sterilizing in a sterilizing tank, and packaging to obtain the strontium-doped borate bioactive glass.
4. The method for preparing a dressing with skin wound biological induction activity as claimed in claim 3, wherein the sterilization temperature in the steps S1 and S3 is 115-135 ℃.
5. Use of a dressing according to claim 1 for the promotion of wound healing.
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| CN109550071B (en) * | 2018-12-05 | 2021-08-24 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material, preparation method and application thereof, and polyurethane sponge product |
| WO2020113474A1 (en) * | 2018-12-05 | 2020-06-11 | 中国科学院深圳先进技术研究院 | Polyurethane sponge material, preparation method therefor, use thereof and polyurethane sponge article |
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| CN113698560B (en) * | 2021-09-13 | 2024-01-26 | 深圳先进技术研究院 | Antibacterial and anti-inflammatory composite hydrogel precursor liquid and preparation method and application thereof |
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