CN202191515U - Composite sponge dressing - Google Patents
Composite sponge dressing Download PDFInfo
- Publication number
- CN202191515U CN202191515U CN2011201497371U CN201120149737U CN202191515U CN 202191515 U CN202191515 U CN 202191515U CN 2011201497371 U CN2011201497371 U CN 2011201497371U CN 201120149737 U CN201120149737 U CN 201120149737U CN 202191515 U CN202191515 U CN 202191515U
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- chitosan
- wound
- sponge
- dressing
- polyvinyl alcohol
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Abstract
The utility model discloses a composite sponge dressing which is characterized by consisting of a non-woven layer and a chitosan sterilization sponge adhered onto the non-woven layer. The non-woven layer is provided with breathable micropores. The chitosan sterilization sponge comprises polyvinyl alcohol and chitosan or comprises gentamicin, polyvinyl alcohol and chitosan, wherein the proportion of the polyvinyl alcohol and the chitosan is 10:1-1:10. The non-woven layer is provided with the breathable micropores so as to achieve the effects of isolating bacteria and protecting the surface of a wound; the chitosan sterilization sponge is in direct contact with the surface of the wound, while the dressing is not adhered to the surface of the wound; the polyvinyl alcohol possibly improves the film-forming property and persistence of the chitosan; and the gentamicin can better inhibit bacterium growth and achieves long-acting sterilization. The composite sponge dressing can cover the surface of the wound, contributes to wound healing, prevents bacterial attack, can be clung to the surface of the wound, absorb the exudate out of the surface of the wound, and has certain flexibility and strength.
Description
[technical field]
This utility model belongs to medical dressing field, and more particularly, this utility model relates to a kind of sponge material of preventing and treating wound infection and short its reparation.
[background technology]
The wound of skin is clinical common disease, and the method for general treatment is to adopt dressing covering and protection and provide the environment that is beneficial to wound healing.For a comparatively long period of time, using the most general surgical wound dressings is medical absorbent cotton and gauze.It can play certain facilitation to the treatment of wound, but has very big deficiency.When for example it used, the wound surface granulation tissue was grown in dressing and is caused adhesion; During releasing, be prone to cause the secondary wound; Owing to the wound surface hydrops is prone to cause bacterial infection.
Chitosan has excellent biological compatibility and biodegradability, and has functions such as good film property, anticoagulant property, promotion wound healing and anti-corrosive antibacterial, and purified chitosan fine powder can promote wound healing significantly.The thin film of processing with chitosan, or with other fiber such as Cotton Gossypii, cellulose etc. altogether the non-woven fabrics made of mud can be used as good wound dressing, be used for protecting wound surface; With the various medical number material that chitin fiber is processed, the clinical practice that supplies scald, scratch, laceration of skin etc., evident in efficacy; Show that mainly wound is reactionless, have the effect of antibacterial, antiinflammatory, promotion tissue growth, shortened the curative effect cycle; And the wound surface after the healing is similar with normal structure, no cicatrix.Because it is the antigenicity of chitosan is weak and good biocompatibility, therefore of many uses at pharmaceutical sanitary fields such as burn, wound, cornea disease, beauty treatment, orthopedic, hard tissue repair, wound surface hemostasis.But it is poor, yielding that present list exists pliability with chitosan as external dressing, and bactericidal effect waits not enough inadequately by force.
Polyvinyl alcohol is a kind of nontoxic, non-irritating hydrophilic high polymer, has advantages such as good film-forming property, pliability are strong, safety non-toxic, has been widely used in pharmaceutical preparation, effects such as performance control drug release or protection formulation products profile.
[summary of the invention]
This utility model is to the deficiency of existing medical absorbent cotton, gauze and surgical wound dressings; A kind of composite sponge dressing is provided, and this dressing is made up of nonwoven layer and the chitosan antibacterial sponge that adheres on the nonwoven layer, and nonwoven layer is provided with ventilative micropore; Can play effect at a distance from bacterium, protection wound surface; Chitosan antibacterial sponge directly contacts with wound surface, but the adhesion of dressing and wound surface can not take place, and polyvinyl alcohol wherein can improve the film property and the persistency of chitosan; Gentamycin is bacteria growing inhibiting better, realizes long-acting bactericidal.The composite sponge dressing of this utility model can not only flap coverage, helps wound healing, prevents bacteria attack, can also be close to wound surface, absorbs from the effusive transudate of wound surface, and has certain pliability and intensity.
The technical scheme that this utility model is dealt with problems and adopted:
A kind of composite sponge dressing, this dressing is made up of nonwoven layer and the chitosan antibacterial sponge that adheres on the nonwoven layer.
Described nonwoven layer is provided with ventilative micropore.
Described chitosan antibacterial sponge is for including the chitosan antibacterial sponge that ratio is 10: 1 to 1: 10 polyvinyl alcohol and chitosan.
Described chitosan antibacterial sponge for comprise gentamycin, ratio is the chitosan antibacterial sponge of 10: 1 to 1: 10 polyvinyl alcohol and chitosan.
The beneficial effect of this utility model: this dressing is made up of nonwoven layer and the chitosan antibacterial sponge that adheres on the nonwoven layer; Nonwoven layer is provided with ventilative micropore, can play the effect at a distance from bacterium, protection wound surface, and chitosan antibacterial sponge directly contacts with wound surface; But the adhesion of dressing and wound surface can not take place; Polyvinyl alcohol wherein can improve the film property and the persistency of chitosan, and gentamycin is bacteria growing inhibiting better, realizes long-acting bactericidal.The composite sponge dressing of this utility model can not only flap coverage, helps wound healing, prevents bacteria attack, can also be close to wound surface, absorbs from the effusive transudate of wound surface, and has certain pliability and intensity.
[description of drawings]
Fig. 1 is the sketch map of this utility model
Among the figure: 1, nonwoven layer; 2, chitosan antibacterial sponge
[specific embodiment]
Combine following instance to further describe this utility model, the following example is intended to further illustrate this utility model method for preparing at present, and these embodiment do not limit the present invention in any way the scope of the claim that awaits the reply.
Embodiment 1: the preparation of composite sponge dressing
With deacetylation be 86%, the hydrochloric acid chitosan of viscosity 0.65pa.s, be dissolved in the distilled water, process chitosan-containing 5% (W/V) glue.Other gets polyvinyl alcohol (model 1750 ± 50) and is dissolved in the water; Process the poly-vinyl alcohol solution of 5% (W/V); 5% (W/V) poly-vinyl alcohol solution and 5% (W/V) chitosan glue are mixed and made into mixed solution according to 1: 5 volume ratio; Be poured in the nappy (thickness is about 5-12mm), in-20 ℃ of refrigerators, behind the freezing 6-8h, freeze cool-drying and handle the formation sponge.Take out sponge;, sponge one side adheres on the nonwoven layer after dipping in a small amount of 75% ethanol; Suitable size is cut into the sponge that lyophilizing is handled in dry back under aseptic condition; And aseptic being packaged in the transparent or semitransparent polyurethane packaging material, cobalt 60 radiation sterilizations with 10-30KGy promptly get composite sponge dressing.
As shown in Figure 1, this chitosan antibacterial dressing comprises nonwoven layer 1, chitosan antibacterial sponge 2, and nonwoven layer 1 is provided with ventilative micropore, is stained with chitosan antibacterial sponge 2 on it.
Embodiment 2: contain the preparation of the composite sponge dressing of gentamycin
With deacetylation be 86%, the chitosan of viscosity 0.65pa.s, be dissolved in the acetum of 3% (V/V), process chitosan-containing 5% (W/V) glue.Other gets polyvinyl alcohol (model HA26) and is dissolved in the water; Process the poly-vinyl alcohol solution of 5% (W/V); 5% (W/V) poly-vinyl alcohol solution and 5% (W/V) chitosan glue are mixed and made into mixed solution according to 5: 1 volume ratio, add the injection liquid of gentamicin mixing, be poured in the nappy (thickness is about 5-12mm); In-20 ℃ of refrigerators, behind the freezing 6-8h, freeze cool-drying and handle the formation sponge.Take out sponge;, sponge one side adheres on the nonwoven layer after dipping in a small amount of 75% ethanol; Suitable size is cut into the sponge that lyophilizing is handled in dry back under aseptic condition; And aseptic being packaged in the transparent or semitransparent polyurethane packaging material, cobalt 60 radiation sterilizations with 10-30KGy promptly get composite sponge dressing.
Embodiment 3: the bacteriostatic test of composite sponge dressing
At first preparation mixes the bacterium culture medium flat board, and a little cultured staphylococcus aureus of picking, bacillus pyocyaneus and escherichia coli slant culture are processed bacteria suspension in physiological saline solution 5ml respectively with inoculating loop.Get in the culture dish that bacteria suspension 1.0ml is added to sterilizing-drying, add and be cooled to the common nutrient broth agar culture medium about 50 ℃, shake up, treat after the abundant condensation subsequent use.Carry out bacteriostatic test then, the composite sponge dressing of embodiment 2 preparation is cut into the disk of 1.0cm, mix on the bacterium culture medium flat board through being affixed on behind the ultraviolet disinfection 30min.Do blank with method with collagen sponge, be inverted for 35 ℃～37 ℃ and cultivate 20～24h, observe the bacterial growth situation.The composite sponge dressing of embodiment 2 preparations all has stronger inhibitory action to staphylococcus aureus, bacillus pyocyaneus and escherichia coli, and antibacterial circle diameter reaches more than the 2.0cm.
Embodiment 4: the short tissue injury healing test of composite sponge dressing
The wista mouse that body weight is about 170-200g is divided into 3 groups at random, every group of 10 animals.Animal is anaesthetized sb. generally through lumbar injection (0.5mg/100g body weight) with 7% chloral hydrate.The back fixedly animal of anesthesia is also shaved the hair except that the back; Shave the hair district holostrome skin trauma sample that to cut away a diameter be 1cm then at its back; Be attached at the site of injury of three groups of laboratory animals respectively with composite sponge dressing, common hospital gauze and the clinical practice adhesive bandage of embodiment 1 preparation; And with the fixing sponge of an elastic bandage of sterilizing, after wrapping the 5th day and the 12nd day can obtain system and histological result of study.
The histologic analysis of wound: after totally checking skin wound sample, at once in the neutral formalin solution with sample stuck-at-0% (volume ratio) with the sponge wrapping.The skin wound tissue is become the shred of 0.5cm * 2.5cm by vivisection, and is embedded in the hard paraffin, is cut into the 4um size, then uses HE stain.Healing effect is obtained by Histological research.
The computerized morphometric Analysis of epidermal wound healing: miniature wound sample is positioned on the microscope carrier; Then image is shown on the computer screen by means of CCD camera (Mitsubishi); Utilize a kind of image analysis software; Through measuring the distance of wound left and right edges in the screen, thereby obtain the refresh rate of wound epidermis.Then, can confirm the length of the new epithelial tissue that produces of wound surface, this length is defined as the length overall of the epidermis of the new growth of wound left and right edges.
The result shows: after the 12d, generally, three experimental mice wounds almost cover with newborn epithelial tissue again; Histological research finds; Wrapping hospital gauze group obviously is worse than chitosan-polyvinyl alcohol lyophilizing sponge group and clinical practice adhesive bandage group at wound healing effect, simultaneously, though the composite sponge dressing of embodiment 1 preparation and clinical practice adhesive bandage group naked eyes are seen roughly suitable; The histology shows similar: skin is suitable for reading almost completely to be covered by thin epithelium; The deckzelle of epithelium just can be regarded breeding and the initial stage of breaking up gradually as, in addition, finds to have healing fiber vascular tissue on the corium; This tissue contains fiber, the blood vessel of deposition collagen and expansion.They are similar in nature; Utilize computerized morphometry credit to analyse; Through measuring the length of the new epithelium of growth from two edges, the speed of wound healing of finding them also is close to identical, the composite sponge dressing of embodiment 1 preparation even more even more ideal with the adhesive bandage group than clinical.In a word, the composite sponge dressing of this utility model preparation has ideal short tissue injury healing ability.
Claims (2)
1. composite sponge dressing is characterized in that: this dressing is made up of nonwoven layer and the chitosan antibacterial sponge that adheres on the nonwoven layer.
2. a kind of composite sponge dressing as claimed in claim 1 is characterized in that: described nonwoven layer is provided with ventilative micropore.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201497371U CN202191515U (en) | 2011-05-12 | 2011-05-12 | Composite sponge dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011201497371U CN202191515U (en) | 2011-05-12 | 2011-05-12 | Composite sponge dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN202191515U true CN202191515U (en) | 2012-04-18 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011201497371U Expired - Fee Related CN202191515U (en) | 2011-05-12 | 2011-05-12 | Composite sponge dressing |
Country Status (1)
| Country | Link |
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| CN (1) | CN202191515U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109505124A (en) * | 2018-12-04 | 2019-03-22 | 东华大学 | A kind of antibacterial cotton sticking patch and its preparation and application |
| CN114010835A (en) * | 2021-10-28 | 2022-02-08 | 安徽同力新材料有限公司 | Production process of ultrahigh-filtration medical breathable bag beneficial to healing |
-
2011
- 2011-05-12 CN CN2011201497371U patent/CN202191515U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109505124A (en) * | 2018-12-04 | 2019-03-22 | 东华大学 | A kind of antibacterial cotton sticking patch and its preparation and application |
| CN114010835A (en) * | 2021-10-28 | 2022-02-08 | 安徽同力新材料有限公司 | Production process of ultrahigh-filtration medical breathable bag beneficial to healing |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120418 Termination date: 20130512 |