CN103341203A - Medical dressing, preparation method of medical dressing and preparation method of dressing plaster - Google Patents
Medical dressing, preparation method of medical dressing and preparation method of dressing plaster Download PDFInfo
- Publication number
- CN103341203A CN103341203A CN2013102535251A CN201310253525A CN103341203A CN 103341203 A CN103341203 A CN 103341203A CN 2013102535251 A CN2013102535251 A CN 2013102535251A CN 201310253525 A CN201310253525 A CN 201310253525A CN 103341203 A CN103341203 A CN 103341203A
- Authority
- CN
- China
- Prior art keywords
- dressing
- spirulina
- wound
- ion
- gram
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Abstract
The invention provides a medical dressing, a preparation method of the medical dressing and the preparation method of a dressing plaster. The medical dressing comprises spirulina, spirulina extract and Chinese herbal medicines, wherein the spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ions and vitamins. The dressing plaster comprises a base layer, a bonding layer, an absorbing layer and a treating layer which are stacked sequentially, wherein the treating layer contains the dressing. The dressing comprising the spirulina and the spirulina extract has the treatment functions of stopping bleeding, promoting wound healing, killing and inhibiting bacteria, relieving pain and the like, and can be used for preventing wound infection. The dressing plaster has the functions of the dressing and is easy to use.
Description
Technical field
The present invention relates to a kind of medical treatment and nursing articles for use, relate to a kind of medical dressing, medical dressing manufacture method particularly and comprise the manufacture method of the dressing paste of this dressing.
Background technology
Adhesive bandage also can be described as dressing paste, is a kind of external hygienic material commonly used during people live, and has hemostasis, protects creation usefulness.It is to be made of with the microscler adhesive plaster that a fritter soaked the sliver of medicine the centre, because the restriction of its structure, it is neatly clean, hemorrhage few and don't need the emergency protection of minor cut or wound of sewing up that adhesive bandage only is applicable to that wound is comparatively shown shallow, wound.But the service time of adhesive bandage is unsuitable long, needs short-term frequently to change.If use it after for a long time, the outer field adhesive plaster of adhesive bandage is airtight, will make skin whitening, the deliquescing of wound and wound circumference, causes the secondary infection of antibacterial.Like this, wound is worsened more.
Moreover, for the wound that infects or wound surface is bigger or darker, because water absorption and the breathability of adhesive bandage are all relatively poor, make the bacterial growth breeding easily, increase the weight of or cause infection.
On the other hand, when adhesive bandage contacts with wound, usually can be bonded together with lymph fluid and the blood that wound is gushed out, treat to be difficult to tear behind the wound healing, when overexerting, can make the healing position break again and bleed.Be head it off, increased the sealing coat that prevents that adhesion from adhering in the prior art, cause wound healing slack-off.
In view of this, develop the strong new medical subsides of antimicrbial power and have a great deal of practical meanings, it will avoid the secondary infection of existing adhesive bandage, and also can play antibiotic, the more effect of wound for bigger or darker wound.
Further, expect that this novel medical subsides have treatment functions such as sterilization, minimizing pain simultaneously, make it possible to disposable finish wrapping, protection and the treatment of infected wound.
Be known that spirulina is a kind of natural algae of safety non-toxic, prove repeatedly and experimental results demonstrate that through the expert it does not have any toxicity to human body, can use safely.It is widely used as the health food of a kind of extra-nutrition, raising immunity.
Can recognize that spirulina is edible and with health role.But, not openly spirulina and the application of extract aspect medical subsides thereof.
Summary of the invention
In order to overcome the deficiencies in the prior art, one object of the present invention is the dressing paste that a kind of medical dressing with the treatment function that strengthens anti-infection ability, promotes wound healing and preparation method thereof is provided and makes with this dressing.
Another object of the present invention provides a kind of manufacture method with the dressing paste that promotes wound healing, sterilization, antibacterial, the medical dressing that reduces treatment functions such as pain and make with this dressing.
An aspect of of the present present invention provides a kind of medical dressing, and it comprises: spirulina and/or its extract, wherein the extract of spirulina comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin.
Further, described ion comprises that multiple in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, the potassium ion, described vitamin comprise multiple among vitamin A, C, E, B1, B2, B6, the B12.
Further, described dressing is mixed with the body fluid that following Chinese medicine infusion obtains: have the bactericidal antiphlogistic effect Chinese medicine, have anastalsis Chinese medicine, have the Chinese medicine of analgesic effect and/or have the detumescence effect Chinese medicine, promote the Chinese medicine of wound healing or promoting muscle growth functions.
Further, described Chinese medicine comprises multiple in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, the Radix Notoginseng.
Further, described dressing contains Mel.
Further, described dressing obtains according to following steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly.
On the other hand, the invention provides a kind of manufacture method of medical dressing, it may further comprise the steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly and obtain described medical dressing.
On the other hand, the invention provides a kind of manufacture method of dressing paste, it may further comprise the steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly and obtain medical dressing;
Step S400: aforementioned medical dressing is spread upon on the dressing paste equably.
Further, in step S400 every square metre smear the medical dressing that 300-600 milliliter step S300 makes.
Further again, described dressing paste has second district that is positioned at the center and first district that surrounds this second district, and carry out step S500 in described second district: the medical dressing that makes with every square metre of 200-400 milliliter step S300 in second district is proceeded to smear or spray, and makes described treatment layer dry.
The useful technique effect of the technique scheme of the embodiment of the invention is:
Therefore product of the present invention has very strong inhibitory action to pathogenic microorganism owing to adopt spirulina and extract thereof as anti-biotic material, and uses safety, and human body is had no side effect.When adding Chinese medicine, the microcirculation of the damage of bactericidal antiphlogistic, and improvement effectively surrounding tissue plays the effect of analgesia, inhibition bacterial reproduction and reparation wound.
Description of drawings
The present invention is further described below in conjunction with drawings and Examples.
Fig. 1 is the vertical view according to the dressing paste of one embodiment of the present invention;
Fig. 2 is that dressing paste shown in Fig. 1 is along the profile of A-A ' line;
Fig. 3 is the vertical view according to the dressing paste of another embodiment of the present invention;
Fig. 4 is that dressing paste shown in Fig. 3 is along the profile of B-B ' line.
The specific embodiment
For making the purpose, technical solutions and advantages of the present invention more cheer and bright, below in conjunction with the specific embodiment and with reference to accompanying drawing, the present invention is described in more detail.Should be appreciated that these descriptions are exemplary, and do not really want to limit the scope of the invention.In addition, in the following description, omitted the description to known features and technology, to avoid unnecessarily obscuring concept of the present invention.
In the medical dressing of the embodiment of the invention, the most important thing is to include spirulina and extract thereof, wherein the extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide, ion and vitamin.Active substance has superoxide dismutase.Ion comprises that multiple in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, the potassium ion, vitamin comprise multiple among vitamin A, C, E, B1, B2, B6, the B12.
In addition, contain a large amount of calcium ions in the spirulina extract, can promote the formation of thrombokinase.Spirulina and extract thereof have into colloidality.Specifically, Na+/Ca2+ ion exchange by taking place with sepage in spirulina and extract thereof, form the stable netted gel of one deck on the wound surface, thereby be beneficial to the microenvironment (little acid, anaerobic or hypoxia, appropriate moistening) of tissue growth for wound/one of wound construction.This little acid, anaerobic or hypoxia, the moistening wound environment of appropriateness have promoted the release of somatomedin, stimulate cellular proliferation, and the regeneration capacity and the cell that improve epidermis cell move, thereby promote wound healing; Phycocyanin in the spirulina extract, chlorophyll etc. have the effect of tangible promotion wound healing simultaneously.
Owing to the gel that has formed protective effect in wound surface, so wound surface forms confined space, so that wound and extraneous antibacterial are isolated; Simultaneously, the environment moistening, little acid in the confined space is conducive to neutrophilic granulocyte and plays a role, thereby strengthens the local bactericidal ability, reduces infection rate.On the other hand, the polysaccharide in the extract can improve the nonspecific cellular immune function of body, and can promote body to change different in nature humoral immune function, thereby improves the ability of resisting pathogenic bacteria, poisoning intrusion.
By forming gelatinous protecting film (water gel), can avoid occurring wound infection according to the dressing of the embodiment of the invention.Owing to have a stronger anti-infection ability, it is big or than the treatment of gash that it can also be used for wound surface.
The stimulation of outer bound pair wound surface is avoided slightly in the effective neuroprotective of the water gel end that the surface forms, and eliminates damage, so cicatrization is few.On the other hand, because water gel is difficult for and the wound adhesion, so behind wound healing, be easy to remove, reduce wound pain.Therefore, in use, do not need additionally to add sealing coat of the prior art, save cost.
Below by an embodiment experiment effect of above-mentioned dressing and dressing paste is described:
Example 1:
The observation of curative effect of spirulina dressing treatment chronic infection wound
Successively dock subject chronic infection wound patient 85 examples altogether at Beijing hospital dressing room from year July in March, 2010-2011, male's 50 examples wherein, women's 35 examples.6-59 years old ages.Wound: (2cm * 2cm * 1cm)-(5cm * 4cm * 0.5cm).Wound site: extremity 55 examples, breast abdomen 16 examples, back and other positions 14 examples.1-6 months wound persistent period.Wound 50 examples wherein, postoperative infection 20 examples, burn and scald infects 10 routine animal bite 5 examples.
Assessed and diagnostic test by inquiry medical history, wound part by the nurse during first visit, understand patient's health status.Through comprehensive assessment, all selected patients all do not have the systemic disease that influences wound healing, and antibacterials were all once used in the wound part, and the wound exudate antibacterial culturing all has infection in various degree.The nurse is divided into observation group's 45 example and matched group 40 examples by assessment result and the suitable principle of primary condition.Two groups of patient's basic condition comparing difference not statistically significants have comparability.
7-10 days collection wound exudate are done the antibacterial cultivation two groups of wounds reach treatment by standard method and before treating after.The therapeutic effect that compares wound infection.Treating preceding two groups wound all has in various degree infection, is mainly staphylococcus aureus, staphylococcus epidermidis, streptococcus pyogenes, Pseudomonas aeruginosa, escherichia coli, Klebsiella Pneumoniae etc., and wherein 5 examples merge fungal infection.
Spirulina dressing manufacture method can be omitted its detailed description at this according to the technology preparation of existing technology or exploitation in the future.
Observation group is adopted following treatment of wounds method: adopt the spirulina dressing treatment.Part yellow slough, old granulation are arranged and ooze out more wound for basilar part, with normal saline clean a wound and surrounding skin after, wound cover is close in spirulina dressing.1 time/day, treat after 7-10 days that wound stops to ooze out, necrotic tissue cleaning is thorough, looks wound depth, scope, changes 2-3 days into and changes dressings 1 time.Assess wound curative effect when at every turn changing dressings.Matched group adopts following treatment of wounds method: treat wound according to a conventional method, 1 time/day, change 2-3 days into after 7-10 days and change dressings 1 time.
Observation index and efficacy assessment standard: minimizing/removal, wound surface color and luster, granulation growth, the healing time of observing dressing change frequency, time and the wound secretion of two groups of wounds.The effective evaluation standard is as follows: healing: the wound epithelium covers fully, detects local non-oxidation reaction through 3% hydrogen peroxide; Effectively: wound secretion reduces or wound surface dwindles; Invalid: wound surface does not have change or deepens, enlarges before and after treatment.
Observation group with the spirulina dressing treatment after 7-10 days the wound exudate antibacterial culturing all negative, the infected wound cure rate is 100.0%, the matched group conventional therapy after 7-10 days wound exudate antibacterial culturing 15 example negative, the infected wound cure rate is 37.5%, two groups relatively, and difference has statistical significance (X
2=42.05, P＜0.01).Curative effect behind two groups of Wound healing and bone regenerations relatively sees Table 1.
Effective percentage (%) and II phase healing rate (%) behind the table 1 liang group Wound healing and bone regeneration
Wound is to reach healing by disintegration tissue repair, wound contraction and epithelium regeneration.And wound infection causes bacteriotoxin solubilising protein and collagen fiber, causes bleeding and thrombosis, influences wound healing; Infection simultaneously causes that synthetic hormone reduces, and hormone breaddown increases, and causes hypermetabolism state and sepsis, it is more difficult to cicatrize a wound, and antibacterials are abused in recent years, make the caused infected wound of conditioned pathogen Resistant strain be difficult to control, cause the wounds delay healing.Medical, the medical value of spirulina obtain the whole world and extensively admit, now the mechanism of action of spirulina dressing in the chronic infection wound repair is described below: the polysaccharides and the phycocyanin that contain in (1) spirulina have the good restraining bacterial action, spirulina has very strong promotion humoral immunization effect simultaneously, strengthens functions such as lymphocyte activity.(2) spirulina has the active and increase DNA reparation anabolic effect to the excision of damage dna of obvious raising Cobra venom endonuclease, thereby has strengthened the repair of cell to DNA damage.
Clinical observation shows that spirulina dressing treatment chronic infection wound is a kind of safe and effective therapeutic method.Spirulina is worth clinical application.
In another embodiment, medical dressing of the present invention is mixed with the liquid that following one or more Chinese medicine infusions obtain: have the bactericidal antiphlogistic effect Chinese medicine, have anastalsis Chinese medicine, have the Chinese medicine of analgesic effect and/or have the Chinese medicine of detumescence effect.Can select to have the Chinese medicine of above-mentioned various effects according to concrete purposes.
Particularly, dressing can be mixed with at least a in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, the Radix Notoginseng.Further, this dressing can contain Mel.
In one embodiment, the medical dressing of the embodiment of the invention obtains by following steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly.
Wherein, the capacity of water can also be 3500,4000,4500,5000,5500 milliliters among the step S100; Boil the back and the persistent period can also be 30,40,50 minutes etc., boil the back when continuing the long period when being desirably in, can turn the firepower of firing equipment down; The liquid capacity that takes out among the step S200 correspondingly can correspondingly be 1750,2000,2250,2500,2750 milliliters.But be not limited to aforementioned proportion, can do suitable adjustment on the aforementioned proportion basis.
Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis and Mel have the bactericidal antiphlogistic effect, so that opposing pathogenic microorganism and pathogenic microbe killing promote growth and the reparation of damaged blood vessels neurocyte, and the vigor that recovers subcutaneous blood capillary cell.Radix Notoginseng and Folium Nelumbinis have the effect of hemostasis removing heat from blood, can reduce and ooze out, ease the pain, and promote wound healing, protect from infection.Radix Notoginseng also has the effect of pain relieving and detumescence.
For example, can with above-mentioned quality or volume roughly proportional more Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng be dissolved in the water, obtain liquid by the above-mentioned steps preparation; Then this liquid and spirulina and/or its extract and Mel are mixed mutually, make dressing, to realize making in enormous quantities.That is to say that above-mentioned quality or volume are exemplary, so long as roughly proportional with this tittle, can make the dressing of similar effect.
Owing to contain the medicine that possesses the bactericidal antiphlogistic function in this dressing, so can in time repair wound, accelerating wound.
The following describes the action principle of this dressing paste.
The dressing paste of the embodiment of the invention comprises stacked successively basic unit, adhesive layer, absorbed layer and contains the treatment layer of the dressing that comprises spirulina and extract thereof.Absorbed layer can be positioned at the centre position of adhesive layer.
The manufacture method of the dressing paste of the embodiment of the invention may further comprise the steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly and obtain described medical dressing;
Step S400: aforementioned medical dressing is spread upon equably on the absorbed layer of dressing paste, form the treatment layer.
Wherein, the capacity of water can also be 3500,4000,4500,5000,5500 milliliters among the step S100; Boiling the back can also be 30,40,50 minutes the persistent period, boils the back when continuing the long period when being desirably in, and can turn the firepower of firing equipment down; The liquid capacity that takes out among the step S200 correspondingly can correspondingly be 1750,2000,2250,2500,2750 milliliters.But be not limited to aforementioned proportion, can do suitable adjustment on the aforementioned proportion basis.
Further, can be in step S400 every square metre smear the medical dressing that 300-600 milliliter step S300 makes.
In addition, the dressing paste of the embodiment of the invention has second district 242 that is positioned at the center and first district 241 that surrounds this second district, and carry out step S500 in this second district 242: in second district 242, smear the medical dressing that 200-400 milliliter step S300 makes with every square metre and proceed to smear or spray, and make the treatment layer dry.
Except having identical with general adhesive bandage passing through the hemostasia effect that physics oppresses to reach, also have by the formation that promotes thrombokinase according to the dressing paste of the embodiment of the invention and to accelerate the function of coagulation process.
Dressing paste according to the embodiment of the invention can avoid occurring wound infection, the convenient use.Owing to have a stronger anti-infection ability, it is big or than the treatment of gash that it can also be used for wound surface.
Because the effect of the dressing of the embodiment of the invention, at the effective neuroprotective of water gel end that wound surface forms slightly, avoid the stimulation of outer bound pair wound surface, eliminate and damage, so cicatrization is few.On the other hand, because water gel is difficult for and the wound adhesion, so behind wound healing, be easy to remove, reduce wound pain.Therefore, do not need additionally to add sealing coat of the prior art, simplify production technology.
In one embodiment, be the mixture that spirulina and extract thereof and Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Mel, Radix Notoginseng get through the bubble boiling for the preparation of the dressing of dressing paste.In addition, other architectural feature of this dressing paste and the individual features of the dressing paste shown in Fig. 1 are roughly the same, do not repeat them here.
Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis and Mel have the bactericidal antiphlogistic effect, so that opposing pathogenic microorganism and pathogenic microbe killing promote growth and the reparation of damaged blood vessels neurocyte, and the vigor that recovers subcutaneous blood capillary cell.Radix Notoginseng and Folium Nelumbinis have the effect of hemostasis removing heat from blood, can reduce and ooze out, ease the pain, and promote wound healing, protect from infection.Radix Notoginseng also has the effect of pain relieving and detumescence.
Owing to contain the medicine that possesses the bactericidal antiphlogistic function in this dressing, so can in time repair wound, accelerating wound.Like this, the dressing paste that utilizes this medicine carrying dressing to make can disposablely be finished wrapping, protection and the treatment of infected wound.
Moreover general adhesive bandage can not be used for the treatment of scald, burn, in order to avoid suppurative infection occurs.According to the dressing paste of present embodiment, the appropriate proportioning of the component by selecting dressing reaches the multiple effect that improves microcirculation, promotes tissue regeneration, antiinflammatory and acceleration ulcer healing, can be used in to scald and the treatment of burn.
Fig. 1 is the vertical view according to the dressing paste of one embodiment of the present invention.Fig. 2 is that dressing paste shown in Fig. 1 is along the profile of A-A ' line.This dressing paste comprises stacked successively basic unit 11, adhesive layer 12, absorbed layer 13 and contains the treatment layer 14 of the dressing that comprises spirulina and/or its extract.Except spirulina and/or its extract, dressing can also comprise additives such as cosolvent.As shown in Figure 2, absorbed layer 13 is positioned at the centre position of adhesive layer 12, and treatment layer 14 is positioned on the absorbed layer 13, and its length can equate that perhaps absorbed layer 13 and treatment layer 14 specific adhesion layer 12 are narrow.
The material of basic unit 11 can be a kind of in non-woven fabrics, PVC film with holes and the spandex fabric.The material of adhesive layer 12 can be a kind of in pressure sensitive adhesive, PUR and the adhesive sticker.The material of absorbed layer 13 can be that non-woven fabrics or modification can absorb the azelon fabric.The extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide and ion.
For example, the manufacture method of this dressing paste can be as follows: adopt to spray or the running roller method evenly is laid on the surface of the basic unit 11 that PCV film with holes constitutes with adhesive sticker, to form adhesive layer 12; Place suitably big or small non-woven fabrics the surface of adhesive layer 12 to hit exactly, to form absorbed layer 13; Be coated in dressing of the present invention on the absorbed layer 13 and carry out drying, thereby form treatment layer 14.Spirulina and extract thereof can omit its detailed description at this according to the technology preparation of existing technology or exploitation in the future.Although in the drawings with the form of layering each functional layer of having drawn, those skilled in the art can easily know, can some or all ofly permeate between each layer, in conjunction with, overlapping.For example, treatment layer 14 has a little microbedding infiltration in absorbed layer 13.Other layers can have interpenetrative like this structure equally.
Fig. 3 is the vertical view according to the dressing paste of another embodiment of the present invention.Fig. 4 is that dressing paste shown in Fig. 3 is along the profile of B-B ' line.This dressing paste comprises stacked successively basic unit 21, adhesive layer 22, absorbed layer 23 and contains the treatment layer 24 of the dressing that comprises spirulina and extract thereof.Except spirulina and extract thereof, dressing can also comprise additives such as cosolvent.As shown in the figure, absorbed layer 23 and treatment layer 24 are positioned at the centre of adhesive layer 22, and the length for the treatment of layer 24 is less than or equal to the length of absorbed layer 23.Treatment floor 24 comprises first district 241 and second district 242 with different dressing concentration.
The material of basic unit 21 can be a kind of in non-woven fabrics, PVC film with holes and the spandex fabric.The material of adhesive layer 22 can be a kind of in pressure sensitive adhesive, PUR and the adhesive sticker.The material of absorbed layer 23 can be that non-woven fabrics or modification can absorb the azelon fabric.The extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide and ion.
Equally, although in the drawings with the form of layering and zoning drawn each functional layer and functional area, but those skilled in the art can easily know, can some or all ofly permeate between each layer, in conjunction with, overlapping, each district can have different shapes and size.For example, treatment layer 24 has a little microbedding infiltration in absorbed layer 23.Other layers can have interpenetrative like this structure equally.
As shown in Figure 3, first district 241 is oval ring, and second district 242 is oval, and they are about the centrage one-tenth symmetry of this treatment layer.In other embodiments, can form second district that it is shaped as first district of annulus, Q-RING, rhombus ring etc. and has circle, square, rhombus or other suitable shape.
For example, the manufacture method of this dressing paste can be as follows: adopt to spray or the running roller method evenly is laid on the surface of the basic unit 21 that PCV film with holes constitutes with adhesive sticker, to form adhesive layer 22; The surface that the non-woven fabrics that is fit to the wound area size is arranged in adhesive layer 22 hits exactly, to form absorbed layer 23; The dressing that will comprise spirulina and extract thereof is sprayed on the surface except peripheral part of absorbed layer 23 and carries out drying, then be sprayed on this dressing on the zone that is positioned at central authorities of absorbed layer 23 again and carry out drying, thereby form the treatment floor 24 that comprises first district 241 and second district 242, the dressing content in such second district 242 is just greater than first district 241.Those skilled in the art can also be coated in dressing on the absorbed layer by additive method, for example, smears the dressing of variable concentrations respectively in different field.Spirulina and extract thereof can omit its detailed description at this according to the technology preparation of existing technology or exploitation in the future.
About the treatment layer 24 that completes, second district 242 that is positioned at central authorities preferably comprises more spirulina and the extract thereof of high-load than first district 241 of periphery, thereby the position that is conducive to directly contact with wound forms gelatinous protecting film quickly.
In one embodiment, be the mixture that spirulina and extract thereof and Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Mel, Radix Notoginseng form for the preparation of the dressing of dressing paste.In addition, other architectural feature of this dressing paste and the individual features of the dressing paste shown in Fig. 2 are roughly the same, do not repeat them here.
For example, the manufacture method of this dressing paste can comprise: make first mixed solution based on aforesaid step S100, S200, S300; Based on making second mixed solution with the similar step of aforesaid step S100, S200, S300, wherein the weight of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng correspondingly is lower than the weight of the Chinese medicine of the same race that adopts when making first mixed solution, and the weight of spirulina and/or spirulina extract will correspondingly be higher than the spirulina that adopts when making first mixed solution and/or the weight of spirulina extract; First district that first and second mixed solutions are sprayed on the treatment floor that corresponding respectively to of absorbed layer will form respectively (for example, first district 241 among Fig. 3) and second district (for example, second district 242 among Fig. 3) on the zone and carry out drying, thereby forms the treatment layer.
Preferably, the content that is sprayed on corresponding to spirulina and extract thereof in first mixed solution on the zone in first district is lower than the content that is sprayed on corresponding to spirulina and extract thereof in second mixed solution on the zone in second district, and the position that is beneficial to directly contact with wound forms gelatinous protecting film quickly; And the content that is sprayed on corresponding to the above-mentioned Chinese medicine in first mixed solution on the zone in first district is higher than the content that is sprayed on corresponding to these Chinese medicines in second mixed solution on the zone in second district, to strengthen effects such as sterilization, pain relieving.
Owing to contain the medicine that possesses the bactericidal antiphlogistic function in this dressing, so can in time repair wound, accelerating wound.Like this, the dressing paste that utilizes this medicine carrying dressing to make can disposablely be finished wrapping, protection and the treatment of infected wound.
According to the embodiment of the invention, provide have hemostasis, promote wound healing, sterilization, antibacterial, the medical dressing and the dressing paste that reduce treatment functions such as pain.Because the medicine coating that adopts all adopts natural extract material, natural materials, Chinese herbal medicine etc., so it is safety, ecological, environmental protective to human body and has no side effect.
The experiment effect of above-mentioned dressing and dressing paste is below described by an embodiment again:
Example 2:
Year March in March, 2012-2013 is in shallow table abscess patient 65 examples of certain hospital admission, age 18-65 year, wound surface or otch≤2.Get rid of and suffer from diabetes, tuberculosis, allergic constitution person.Last 2 figure place of the identity recognition number that adopts first visit to register are divided into spirulina dressing paste group 33 example and traditional group 32 examples at random divided by 2 method.
Behind the otch routine disinfection, the capable local anesthesia of 2% lidocaine hydrochloride is cut along the abscess major diameter, to the focus edge, removes the inner slough of abscess and pus, fills the kpetrolatum gauze bar in the otch, and operation is finished in the wrapping of external use sterile gauze.Begin next day to change dressings, the next day 1 time.Cover otch with spirulina dressing when spirulina dressing group is changed dressings, cover wound with common dressing when traditional group is changed dressings, until wound healing.Healing time for from cutting from abscess to the otch required natural law of fully recovering.
In the sepage situation of 2 groups of patient's cutting parts of assessment in the 1st, 3,7 day, did efficacy evaluation, and recorded pain degree, wound healing situation when changing dressings in the 21st day respectively.The assessment of sepage amount and score: estimate the sepage amount and select corresponding score value according to the infiltration situation of dressing.Dry no sepage meter 0 minute, sepage＜5ml was a small amount of meter 1 minute in 24 hours, and 5-10ml is middle amount meter 2 minutes, and 〉=10ml is a large amount of meters 3 minutes.
The sepage amount difference not statistically significant of the 1st day cutting part of 2 groups of patients, the sepage amount spirulina dressing group of the 3rd, 7 day cutting part is less than traditional group; Pain degree average when spirulina dressing group is changed dressings is lower than traditional group, and healing time is shorter than traditional group, sees Table 2.2 groups of patients' total effective rate is 100%, has no adverse reaction.The therapeutic evaluation in the 21st day of spirulina group is better than traditional group, sees Table 3.
The sepage situation of table 2,2 groups of patient's cutting parts, pain degree and healing time are relatively
*P<0.05，**P<0.01
The comparison of table 3,2 groups of patients therapeutic evaluation in the 21st day [example (%)]
| Group | n | Recovery from illness | Produce effects | Take a turn for the better | Invalid |
| The spirulina group | 33 | 24（72.7%） | 7（21.2%） | 2（6.1%） | 0 |
| Traditional group | 32 | 14（43.8%） | 10（31.3%） | 8（25.0%） | 0 |
Z=2.542，P<0.05
Make dressing paste owing to selected for use pure spirulina or extract to make dressing paste, spirulina or extract interpolation Chinese medicine ingredients, find to add Chinese medicine ingredients and make dressing paste, than be separately the dressing paste made with spirulina or extract suppress microorganism, reduce aspect the pain more obvious.Because the spirulina that the embodiment of the invention is selected for use and extract thereof, Chinese crude drug, Mel etc. all are the pure natural materials that do not carry out any artificial interpolation or change, so can guarantee effectively that its effective ingredient is all from above-mentioned material itself.
Because the high osmosis of effective ingredient can be drawn and be organized transudate in the dressing of spirulina group, keep the otch drying, reduce tissue edema, avoid the skin maceration, be conducive to wound healing.This studies the sepage amount difference not statistically significant of the 1st day cutting part of 2 groups of patients, and changes dressings the 3rd day and the 7th day, and the sepage amount of spirulina group cutting part is less than traditional group.
Moisture treatment is that Britain Jorge doctor Winter proposed in 1962, and it is defined as and uses various wet union dressing (or maintenance otch appropriateness is moistening), promotes cell changes and growth, is beneficial to the method for wound healing.Although moisture is few in the spirulina dressing paste, but it provides a moist environment for healing, he is by ion exchange and lock avoiding causing and organizing hydropenia of water effective admittedly, has built the healing environment of the appropriate moistening and little acid of hypoxia for otch, promotes the growth of new granulation tissue.This research spirulina group abscess is cut the patient and is used the spirulina dressing paste, and the 21st day curative effect is better than traditional group, and healing time is shorter than traditional group.
The dressing of this result of study prompting spirulina posts the obvious suppression microorganism, reduces and bear, creation is conducive to the moist environment of tissue growth, accelerates wound healing, effectively alleviates the wound pain degree, promoting granulation tissue growth etc., is a kind of new method safely and effectively.
The above only is exemplary embodiment of the present invention, but not is used for restriction protection scope of the present invention, and protection scope of the present invention is determined by appended claim.
Should be understood that the above-mentioned specific embodiment of the present invention only is used for exemplary illustration or explains principle of the present invention, and is not construed as limiting the invention.Therefore, any modification of under situation without departing from the spirit and scope of the present invention, making, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.In addition, claims of the present invention are intended to contain whole variations and the modification in the equivalents that falls into claims scope and border or this scope and border.
Claims (10)
1. medical dressing, it comprises: spirulina and/or its extract, wherein spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin.
2. dressing as claimed in claim 1, it is characterized in that, described ion comprises that multiple in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, the potassium ion, described vitamin comprise multiple among vitamin A, C, E, B1, B2, B6, the B12.
3. dressing as claimed in claim 2, it is characterized in that described dressing is mixed with the liquid that following Chinese medicine infusion obtains: have the bactericidal antiphlogistic effect Chinese medicine, have anastalsis Chinese medicine, have the Chinese medicine of analgesic effect and/or have the detumescence effect Chinese medicine, promote the Chinese medicine of wound healing or promoting muscle growth functions.
4. dressing as claimed in claim 3 is characterized in that, described Chinese medicine comprises multiple in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, the Radix Notoginseng.
5. dressing as claimed in claim 4 is characterized in that, described dressing contains Mel.
6. dressing as claimed in claim 5 is characterized in that, described dressing obtains according to following steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly.
7. the manufacture method of a medical dressing is characterized in that may further comprise the steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly and obtain medical dressing.
8. the manufacture method of a dressing paste is characterized in that may further comprise the steps:
Step S100: with each 10-20 gram water 3000-6000 milliliter of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng boil the back continue 20-60 minute standby;
Step S200: temperature drops to 20-40 correspondingly takes out the 1500-3000 milliliters of liquid when spending;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid stir evenly and obtain medical dressing;
Step S400: described medical dressing is spread upon equably on the absorbed layer of dressing paste, form the treatment layer.
9. method as claimed in claim 8 is characterized in that smearing the medical dressing that 300-600 milliliter step S300 makes for every square metre in step S400.
10. method as claimed in claim 8, it is characterized in that: described dressing paste has second district that is positioned at the center and first district that surrounds this second district, and carry out step S500 in described second district: the medical dressing that makes with every square metre of 200-400 milliliter step S300 in second district is proceeded to smear or spray, and makes described treatment layer dry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310253525.1A CN103341203B (en) | 2013-06-24 | 2013-06-24 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310253525.1A CN103341203B (en) | 2013-06-24 | 2013-06-24 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103341203A true CN103341203A (en) | 2013-10-09 |
| CN103341203B CN103341203B (en) | 2015-04-22 |
Family
ID=49276061
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310253525.1A Active CN103341203B (en) | 2013-06-24 | 2013-06-24 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103341203B (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611185A (en) * | 2013-12-03 | 2014-03-05 | 安徽缘远博爱生物技术有限公司 | Antiseptic radix sophorae flavescentis soluble hemostatic gauze |
| CN103623458A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Pseudo-ginsheng blood circulation and healing promoting water-soluble hemostatic gauze |
| CN103623459A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Dissoluble hemostatic gauze for sterilizing, diminishing inflammation and promoting granulation |
| CN104307032A (en) * | 2014-11-05 | 2015-01-28 | 天津工业大学 | Liquid dressing capable of stopping pain and bleeding, resisting bacteria and promoting wound healing |
| CN104998295A (en) * | 2015-07-03 | 2015-10-28 | 宁夏职业技术学院 | Liquid woundplast, and preparation method thereof |
| CN105816547A (en) * | 2016-03-30 | 2016-08-03 | 吴美燕 | Method for preparing band-aid unguent |
| CN107617121A (en) * | 2017-10-13 | 2018-01-23 | 广州润虹医药科技股份有限公司 | A kind of skin wound biology induced activity dressing and its preparation method and application |
| CN107929792A (en) * | 2017-12-16 | 2018-04-20 | 广东泰宝医疗科技股份有限公司 | A kind of activated carbon fibre dressing with pain-relieving functions and preparation method thereof |
| CN109432483A (en) * | 2018-11-08 | 2019-03-08 | 广州润虹医药科技股份有限公司 | A kind of medical dressing and its preparation method and application accelerating wound healing |
| CN110124087A (en) * | 2019-06-10 | 2019-08-16 | 江苏农林职业技术学院 | Preparation method based on the adhesive bandage of flavones active component in tasselled leaf |
| CN112999403A (en) * | 2021-03-01 | 2021-06-22 | 中国科学院烟台海岸带研究所 | Preparation method of oral cavity repairing film |
| CN114288459A (en) * | 2021-12-06 | 2022-04-08 | 山东速康医疗科技有限公司 | Preparation method of medical silicone foam dressing |
| CN117224453A (en) * | 2023-11-15 | 2023-12-15 | 北京小鹿科技有限公司 | Antibacterial skin-friendly wet tissue containing camellia and preparation method thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245398A (en) * | 1996-12-09 | 2000-02-23 | 凯尔文·温斯顿·邓肯 | Method of biological control |
| US20020120242A1 (en) * | 2000-12-22 | 2002-08-29 | Tyrrell David John | Absorbent articles with hydrophilic compositions containing botanicals |
| CN1506121A (en) * | 2002-12-09 | 2004-06-23 | 张冠中 | Magnetotherapeutic pain-relieving scar-melting flexible fabric bandage |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN101240243A (en) * | 2007-10-19 | 2008-08-13 | 陈世平 | Fresh water cultivation of series function fresh-keeping spirulina platensis and spirulina maxima |
| CN101249104A (en) * | 2008-03-12 | 2008-08-27 | 耿建华 | Traditional Chinese medicine preparation for eliminating scar |
| CN101797286A (en) * | 2009-07-15 | 2010-08-11 | 袁力克 | Chinese traditional medicine combination for alleviating wound infections and suture reaction after surgery and preparation method thereof |
| CN102336610A (en) * | 2011-09-01 | 2012-02-01 | 安徽师范大学 | Chinese medicine composition for promoting plant wound heeling |
-
2013
- 2013-06-24 CN CN201310253525.1A patent/CN103341203B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1245398A (en) * | 1996-12-09 | 2000-02-23 | 凯尔文·温斯顿·邓肯 | Method of biological control |
| US20020120242A1 (en) * | 2000-12-22 | 2002-08-29 | Tyrrell David John | Absorbent articles with hydrophilic compositions containing botanicals |
| CN1506121A (en) * | 2002-12-09 | 2004-06-23 | 张冠中 | Magnetotherapeutic pain-relieving scar-melting flexible fabric bandage |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
| CN101240243A (en) * | 2007-10-19 | 2008-08-13 | 陈世平 | Fresh water cultivation of series function fresh-keeping spirulina platensis and spirulina maxima |
| CN101249104A (en) * | 2008-03-12 | 2008-08-27 | 耿建华 | Traditional Chinese medicine preparation for eliminating scar |
| CN101797286A (en) * | 2009-07-15 | 2010-08-11 | 袁力克 | Chinese traditional medicine combination for alleviating wound infections and suture reaction after surgery and preparation method thereof |
| CN102336610A (en) * | 2011-09-01 | 2012-02-01 | 安徽师范大学 | Chinese medicine composition for promoting plant wound heeling |
Non-Patent Citations (4)
| Title |
|---|
| 刘志伟: "《察汗淖尔螺旋藻 完美的营养使者》", 31 December 2009, article "螺旋藻的营养成分及营养评价", pages: 66-87 * |
| 杨智勇等: "《旋普瑞医学论文汇编》", 31 December 1996, article "螺旋藻的主要成分和药物作用", pages: 52-59 * |
| 果淑香等: "《创造发明1000例 发明大王 生物卷》", 31 December 2001, article "螺旋藻的发现及其开发利用", pages: 56-60 * |
| 麦燕琼: "《月补越靓》", 31 December 2010, article "螺旋藻的成分", pages: 122 * |
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611185A (en) * | 2013-12-03 | 2014-03-05 | 安徽缘远博爱生物技术有限公司 | Antiseptic radix sophorae flavescentis soluble hemostatic gauze |
| CN103623458A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Pseudo-ginsheng blood circulation and healing promoting water-soluble hemostatic gauze |
| CN103623459A (en) * | 2013-12-03 | 2014-03-12 | 安徽缘远博爱生物技术有限公司 | Dissoluble hemostatic gauze for sterilizing, diminishing inflammation and promoting granulation |
| CN103623458B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of pseudo-ginseng blood-circulation-invigovating promoting healing water-soluble hemostatic gauze |
| CN103623459B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of soluble stanching gauze of germicidal anti-inflammatory myogenic |
| CN103611185B (en) * | 2013-12-03 | 2016-02-24 | 安徽缘远博爱生物技术有限公司 | A kind of Radix Sophorae Flavescentis sterilization soluble stanching gauze |
| CN104307032A (en) * | 2014-11-05 | 2015-01-28 | 天津工业大学 | Liquid dressing capable of stopping pain and bleeding, resisting bacteria and promoting wound healing |
| CN104998295A (en) * | 2015-07-03 | 2015-10-28 | 宁夏职业技术学院 | Liquid woundplast, and preparation method thereof |
| CN105816547A (en) * | 2016-03-30 | 2016-08-03 | 吴美燕 | Method for preparing band-aid unguent |
| CN107617121A (en) * | 2017-10-13 | 2018-01-23 | 广州润虹医药科技股份有限公司 | A kind of skin wound biology induced activity dressing and its preparation method and application |
| CN107617121B (en) * | 2017-10-13 | 2020-09-01 | 广州润虹医药科技股份有限公司 | Biological induction active dressing for skin wound surface and preparation method and application thereof |
| CN107929792A (en) * | 2017-12-16 | 2018-04-20 | 广东泰宝医疗科技股份有限公司 | A kind of activated carbon fibre dressing with pain-relieving functions and preparation method thereof |
| CN109432483A (en) * | 2018-11-08 | 2019-03-08 | 广州润虹医药科技股份有限公司 | A kind of medical dressing and its preparation method and application accelerating wound healing |
| CN110124087A (en) * | 2019-06-10 | 2019-08-16 | 江苏农林职业技术学院 | Preparation method based on the adhesive bandage of flavones active component in tasselled leaf |
| CN112999403A (en) * | 2021-03-01 | 2021-06-22 | 中国科学院烟台海岸带研究所 | Preparation method of oral cavity repairing film |
| CN114288459A (en) * | 2021-12-06 | 2022-04-08 | 山东速康医疗科技有限公司 | Preparation method of medical silicone foam dressing |
| CN117224453A (en) * | 2023-11-15 | 2023-12-15 | 北京小鹿科技有限公司 | Antibacterial skin-friendly wet tissue containing camellia and preparation method thereof |
| CN117224453B (en) * | 2023-11-15 | 2024-02-06 | 北京小鹿科技有限公司 | Antibacterial skin-friendly wet tissue containing camellia and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103341203B (en) | 2015-04-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103341203B (en) | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster | |
| CN107185031B (en) | A kind of biologically active medical dressing and preparation method thereof | |
| CN101879283A (en) | Novel membrane spraying preparation for skin trauma and preparation method | |
| CN102670929B (en) | Composite for injury healing and preparing method thereof | |
| CN101129787A (en) | Burn cream | |
| CN105169455B (en) | A kind of burn and scald external application first aid medical dressing and preparation method thereof | |
| Doanh et al. | The use of a water extract from the bark of Choerospondias axillaris in the treatment of second decree burns | |
| Hu et al. | Clinical efficacy of wet dressing combined with chitosan wound dressing in the treatment of deep second‐degree burn wounds: A prospective, randomised, single‐blind, positive control clinical trial | |
| CN106943235A (en) | Belly protective belt after a kind of caesarean section | |
| CN105709273A (en) | Medical liquid dressing containing polyethylene glycol | |
| CN111012945B (en) | Waterproof traditional Chinese medicine liquid band-aid and preparation method thereof | |
| CN104474536A (en) | Fresh agrimonia pilosa medicine preparation for treating wounds | |
| CN103690903B (en) | A kind of Chinese traditional compound medicine for the treatment of the injuries such as burn and scald decubital ulcer | |
| Hao et al. | Dermlin and silver nanoparticles combined antibacterial dressing for skin wound repair | |
| CN100391479C (en) | Wound protecting and treating smearing prepn | |
| CN109432483A (en) | A kind of medical dressing and its preparation method and application accelerating wound healing | |
| CN102028875B (en) | Medicament for treating open wound and preparation method thereof | |
| CN101332286B (en) | Traditional Chinese medicine composition for treating skin disease and preparation method thereof | |
| CN204275112U (en) | A kind of alginate medical dressing | |
| CN105381101A (en) | Medicine used for treating burns, scalds and bedsore and preparation method thereof | |
| CN105168503B (en) | It is a kind of to be used to prevent external medicine composition of radiodermatitis and preparation method thereof | |
| CN203017195U (en) | Band-aid with silver ion anti-bacterial function | |
| CN101214280B (en) | Chinese medicine for treating burn, scald and sores and preparation thereof | |
| CN110801464A (en) | Sanhua energy-gathering wound emergency medicine oil and preparation method thereof | |
| CN203042644U (en) | Aloe wound paste |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Zhang Yanhai Inventor after: Liu Shuhua Inventor after: Gao Cuijing Inventor before: Zhang Yanhai Inventor before: Chen Shiping Inventor before: Liu Shuhua Inventor before: Gao Cuijing |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: INVENTOR; FROM: ZHANG YANHAI CHEN SHIPING LIU SHUHUA GAO CUIJING TO: ZHANG YANHAI LIU SHUHUA GAO CUIJING |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |