CN103341203B - Medical dressing, preparation method of medical dressing and preparation method of dressing plaster - Google Patents
Medical dressing, preparation method of medical dressing and preparation method of dressing plaster Download PDFInfo
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- CN103341203B CN103341203B CN201310253525.1A CN201310253525A CN103341203B CN 103341203 B CN103341203 B CN 103341203B CN 201310253525 A CN201310253525 A CN 201310253525A CN 103341203 B CN103341203 B CN 103341203B
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Abstract
The invention provides a medical dressing, a preparation method of the medical dressing and the preparation method of a dressing plaster. The medical dressing comprises spirulina, spirulina extract and Chinese herbal medicines, wherein the spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ions and vitamins. The dressing plaster comprises a base layer, a bonding layer, an absorbing layer and a treating layer which are stacked sequentially, wherein the treating layer contains the dressing. The dressing comprising the spirulina and the spirulina extract has the treatment functions of stopping bleeding, promoting wound healing, killing and inhibiting bacteria, relieving pain and the like, and can be used for preventing wound infection. The dressing plaster has the functions of the dressing and is easy to use.
Description
Technical field
The present invention relates to a kind of medical treatment and nursing articles for use, relate to a kind of medical dressing, medical dressing manufacture method particularly and comprise the manufacture method of dressing paste of this dressing.
Background technology
Adhesive bandage, also can be described as dressing paste, is a kind of external sanitary material conventional during people live, has hemostasis, protects creation use.It is made up of the microscler adhesive plaster of sliver of centre with the dipped medicine of a fritter, and due to the restriction of its structure, adhesive bandage is only applicable to wound, and comparatively to show shallow, wound neatly clean, hemorrhage few and don't need the emergency protection of the minor cut or wound sewed up.But the service time of adhesive bandage is unsuitable long, needs short-term frequently to change.If after using it for a long time, the outer field adhesive plaster of adhesive bandage is airtight, will make the skin whitening of wound and wound circumference, deliquescing, causes the secondary infection of antibacterial.Like this, wound will be made more to worsen.
Moreover, for infect or wound surface more greatly or darker wound, due to the water absorption of adhesive bandage and breathability all poor, easily make bacterial growth breed, increase the weight of or cause infection.
On the other hand, when adhesive bandage and Wound contact, the lymph fluid usually can gushed out with wound and blood are bonded together, and are difficult to tear after wound healing, when overexerting, healing position can be made again to break and bleed.For head it off, in prior art, add the sealing coat preventing adhesion from adhering to, cause wound healing slack-off.
In view of this, develop the strong new medical of antimicrbial power and paste and have a great deal of practical meanings, it will avoid the secondary infection of existing adhesive bandage, and for more greatly or darker wound also can play effect that is antibacterial, more wound.
Further, expect that this novel medical plaster has sterilization simultaneously, reduces the treatment function such as pain, make it possible to disposable complete infected wound wrapping, protection and treatment.
It is known that spirulina is a kind of natural algae of safety non-toxic, repeatedly proves and experimental results demonstrate through expert, it, can be used safely without any toxicity human body.It is widely used as the health food of a kind of extra-nutrition, raising immunity.
Can recognize, spirulina is edible and with health role.But, not openly spirulina and the application of extract in medical plaster thereof.
Summary of the invention
In order to overcome the deficiencies in the prior art, one object of the present invention is that providing a kind of has the dressing paste strengthening anti-infection ability, promote medical dressing of the treatment function of wound healing and preparation method thereof and make with this dressing.
Another object of the present invention is to provide a kind ofly has the manufacture method of dressing paste promoting wound healing, sterilization, antibacterial, the medical dressing that reduces the treatment functions such as pain and make with this dressing.
An aspect of of the present present invention provides a kind of medical dressing, and it comprises: spirulina and/or its extract, wherein the extract of spirulina comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin.
Further, it is multiple that described ion comprises in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, potassium ion, and it is multiple that described vitamin comprises in vitamin A, C, E, B1, B2, B6, B12.
Further, described dressing is mixed with the body fluid that following Traditional medicine bubble obtains: the Chinese medicine with bactericidal antiphlogistic effect, the Chinese medicine with anastalsis, have analgesic effect Chinese medicine and/or there is the Chinese medicine of detumescence effect, promote the Chinese medicine of wound healing or promoting muscle growth functions.
Further, what described Chinese medicine comprised in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng is multiple.
Further, described dressing contains Mel.
Further, described dressing obtains according to following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly.
On the other hand, the invention provides a kind of manufacture method of medical dressing, it comprises the following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly and obtain described medical dressing.
On the other hand, the invention provides a kind of manufacture method of dressing paste, it comprises the following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly and obtain medical dressing;
Step S400: aforementioned medical dressing is spread upon on dressing paste equably.
Further, the medical dressing that every square metre is smeared 300-600 milliliter step S300 and obtains in step S400.
Further again, described dressing paste has the secondth district being positioned at center and the firstth district surrounding this secondth district, and carry out step S500 in described secondth district: proceed to smear or spray with the medical dressing that every square metre of 200-400 milliliter step S300 is obtained on the second region, and make described treatment layer dry.
The Advantageous Effects of the technique scheme of the embodiment of the present invention is:
Product of the present invention, owing to adopting spirulina and extract thereof as anti-biotic material, therefore has very strong inhibitory action to pathogenic microorganism, and use safety, to human non-toxic's side effect.During additional Chinese medicine, can bactericidal antiphlogistic effectively, and improve the microcirculation of damaging surrounding tissue, play analgesia, anti-bacteria breeding and repair the effect of wound.
Accompanying drawing explanation
Below in conjunction with drawings and Examples, the present invention is further described.
Fig. 1 is the top view of the dressing paste according to one embodiment of the present invention;
Fig. 2 is the profile of dressing paste shown in Fig. 1 along A-A ' line;
Fig. 3 is the top view of the dressing paste according to another embodiment of the present invention;
Fig. 4 is the profile of dressing paste shown in Fig. 3 along B-B ' line.
Detailed description of the invention
For making the object, technical solutions and advantages of the present invention clearly understand, below in conjunction with detailed description of the invention also with reference to accompanying drawing, the present invention is described in more detail.Should be appreciated that, these describe just exemplary, and do not really want to limit the scope of the invention.In addition, in the following description, the description to known features and technology is eliminated, to avoid unnecessarily obscuring concept of the present invention.
In the medical dressing of the embodiment of the present invention, the most important thing is to include spirulina and extract thereof, wherein the extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide, ion and vitamin.Active substance has superoxide dismutase.It is multiple that ion comprises in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, potassium ion, and it is multiple that vitamin comprises in vitamin A, C, E, B1, B2, B6, B12.
In addition, containing a large amount of calcium ions in spirulina extract, the formation of thrombokinase can be promoted.Spirulina and extract thereof have into colloidality.Specifically, by there is Na+/Ca2+ ion exchange with sepage in spirulina and extract thereof, form the stable network gel of one deck at wound surface, thus build a microenvironment being beneficial to tissue growth (micro-acid, anaerobic or hypoxia, appropriateness moistening) for wound/wound.This micro-acid, anaerobic or hypoxia, the moistening wound climate of appropriateness facilitate the release of somatomedin, stimulate cellular proliferation, improve regeneration capacity and the signaling of epidermis cell, thus promote wound healing; Phycocyanin, chlorophyll etc. simultaneously in spirulina extract have the effect significantly promoting wound healing.
Owing to defining the gel of protective effect in wound surface, so wound surface forms confined space, completely cut off to make wound and extraneous antibacterial; Meanwhile, the environmental benefits of moistening, the micro-acid in confined space plays a role in neutrophilic granulocyte, thus strengthens local bactericidal ability, reduces infection rate.On the other hand, the polysaccharide in extract can improve the nonspecific cellular immune function of body, and can promote that body turns specific humoral immune function, thus improves the ability resisting pathogenic bacteria, poisoning intrusion.
By forming gelatinous protecting film (water gel), can avoid occurring wound infection according to the dressing of the embodiment of the present invention.Owing to having stronger anti-infection ability, it is comparatively large or compared with the treatment of gash that it can also be used for wound surface.
The water gel available protecting nerve ending that surface is formed, avoids the stimulation of outer bound pair wound surface, eliminates damage, so cicatrization is few.On the other hand, due to water gel not easily with wound adhesion, so be easy to remove after wound healing, reduce wound pain.Therefore, in use, do not need additionally to add sealing coat of the prior art, save cost.
The experiment effect of above-mentioned dressing and dressing paste is described below by way of an embodiment:
Example 1:
The observation of curative effect of spirulina dressing treatment chronic infection wound
From in March, 2010-2011, year July successively docks subject chronic infection wound patient at Beijing hospital dressing room and has 85 examples altogether, wherein male 50 example, women 35 example.6-59 years old ages.Wound: (2cm × 2cm × 1cm)-(5cm × 4cm × 0.5cm).Wound location: extremity 55 example, breast abdomen 16 example, back and other positions 14 example.1-6 months wound persistent period.Wherein wound 50 example, postoperative infection 20 example, burn and scald infects 10 routine animal bite 5 examples.
Pass through inquiry medical history, wound local evaluation and diagnostic test by nurse during first visit, understand the health status of patient.Through comprehensive assessment, all selected patients are all without the systemic disease affecting wound healing, and wound local all once used antibacterials, and wound exudate antibacterial culturing all has infection in various degree.Nurse by assessment result and the suitable principle of primary condition be divided into observation group 45 example and matched group 40 routine.Two groups of patient's basic condition comparing difference not statistically significants, have comparability.
Two groups of wounds are by before standard method and treatment and treat afterwards that within 7-10 days, gathering wound exudate does antibacterial culturing.The relatively therapeutic effect of wound infection.The wound for the treatment of first two groups all has infection in various degree, is mainly staphylococcus aureus, staphylococcus epidermidis, streptococcus pyogenes, Pseudomonas aeruginosa, escherichia coli, Klebsiella Pneumoniae etc., and wherein 5 examples merge fungal infection.
Spirulina dressing manufacture method can be prepared according to the technology of existing technology or exploitation in the future, and at this, description is omitted.
Following wound processing method is adopted to observation group: adopt spirulina dressing treatment.There are part yellow slough, old granulation for basilar part and ooze out more wound, clean a wound with normal saline and after surrounding skin, wound covering be close in spirulina dressing.1 times/day, treat after 7-10 days that wound stops oozing out, necrotic tissue cleaning is thorough, depending on wound depth, scope, changes 2-3 days into and changes dressings 1 time.Assess wound curative effect when at every turn changing dressings.Matched group adopts following wound processing method: treat wound according to a conventional method, 1 times/day, changes 2-3 days into and change dressings 1 time after 7-10 days.
Observation index and efficacy assessment standard: observe the dressing change frequency of two groups of wounds, the minimizing/removal of time and wound secretion, wound surface color and luster, granulation growth, healing time.Effective evaluation standard is as follows: healing: wound epithelium covers completely, detects local non-oxidation reaction through 3% hydrogen peroxide; Effective: wound secretion reduces or wound surface reduces; Invalid: wound surface before the treatment after without change or deepen, expand.
Observation group's spirulina dressing treatment after 7-10 days wound exudate antibacterial culturing be all negative, infected wound cure rate is 100.0%, matched group conventional therapy after 7-10 days wound exudate antibacterial culturing 15 example be negative, infected wound cure rate is 37.5%, two groups are compared, and difference has statistical significance (X
2=42.05, P<0.01).Comparitive study after two groups of Wound healing and bone regenerations is in table 1.
Effective percentage (%) and II phase healing rate (%) after table 1 liang group Wound healing and bone regeneration
Wound reaches healing by disintegration tissue repair, wound contraction and epithelium regeneration.And wound infection causes bacteriotoxin solubilising protein and collagen fiber, cause bleeding and thrombosis, affect wound healing; Infect causes synthetic hormone to reduce simultaneously, and hormone breaddown increases, and causes hypermetabolism state and sepsis, cicatrize a wound more difficult, and antibacterials are abused in recent years, make the infected wound caused by conditioned pathogen Resistant strain be difficult to control, cause wounds delay to heal.Medical, the medical value of spirulina obtain the whole world and extensively admit, now the mechanism of action of spirulina dressing in chronic infection wound repair is described below: the polysaccharides contained in (1) spirulina and phycocyanin have good anti-bacteria effect, spirulina has very strong promotion humoral immunization effect simultaneously, strengthens the functions such as lymphocyte activity.(2) spirulina has that to significantly improve Cobra venom endonuclease active and increase DNA and repair anabolic effect to the excision of damage dna, thus enhances the repair of cell to DNA damage.
Clinical observation shows, and spirulina dressing treatment chronic infection wound is one Therapeutic Method safely and effectively.Spirulina clinic is applied.
In another embodiment, medical dressing of the present invention is mixed with the liquid that one or more Traditional medicine bubbles following obtain: the Chinese medicine with bactericidal antiphlogistic effect, the Chinese medicine with anastalsis, have the Chinese medicine of analgesic effect and/or have the Chinese medicine of detumescence effect.According to concrete purposes, the Chinese medicine with above-mentioned various effect can be selected.
Particularly, dressing can be mixed with at least one in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng.Further, this dressing can contain Mel.
In one embodiment, the medical dressing of the embodiment of the present invention is obtained by following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly.
Wherein, in step S100, the capacity of water can also be 3500,4000,4500,5000,5500 milliliters; Boiling the rear persistent period can also be 30,40,50 minutes etc., when be desirably in boil the rear lasting long period time, the firepower of firing equipment can be turned down; The liquid capacity taken out in step S200 correspondingly can be correspondingly 1750,2000,2250,2500,2750 milliliters.But be not limited to aforementioned proportion, suitable adjustment can be done on aforementioned proportion basis.
Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis and Mel have bactericidal antiphlogistic effect, to resist pathogenic microorganism and pathogenic microbe killing, promote growth and the reparation of damaged blood vessels neurocyte, and recover the vigor of subcutaneous capillary cell.Radix Notoginseng and Folium Nelumbinis have the effect of hemostasis removing heat from blood, can reduce and ooze out, ease the pain, and promote wound healing, protect from infection.Radix Notoginseng also has the effect of pain relieving and detumescence.
Such as, by being dissolved in water with above-mentioned quality or the roughly proportional more Cortex Phellodendri of volume, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng, liquid can be obtained by above-mentioned steps preparation; Then this liquid and spirulina and/or its extract and Mel are mixed mutually, make dressing, to realize making in enormous quantities.That is, above-mentioned quality or volume are exemplary, as long as roughly proportional with this tittle, can make the dressing of similar effect.
Due in this dressing containing the medicine possessing bactericidal antiphlogistic function, so wound can be repaired in time, accelerating wound.
The following describes the action principle of this dressing paste.
The dressing paste of the embodiment of the present invention, comprises basic unit stacked successively, adhesive layer, absorbed layer and containing the treatment layer of dressing comprising spirulina and extract thereof.Absorbed layer can be positioned at the centre position of adhesive layer.
The manufacture method of the dressing paste of the embodiment of the present invention, comprises the following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and/or spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly and obtain described medical dressing;
Step S400: spread upon equably on the absorbed layer of dressing paste by aforementioned medical dressing, forms treatment layer.
Wherein, in step S100, the capacity of water can also be 3500,4000,4500,5000,5500 milliliters; Boiling the rear persistent period can also be 30,40,50 minutes, when be desirably in boil the rear lasting long period time, the firepower of firing equipment can be turned down; The liquid capacity taken out in step S200 correspondingly can be correspondingly 1750,2000,2250,2500,2750 milliliters.But be not limited to aforementioned proportion, suitable adjustment can be done on aforementioned proportion basis.
Further, can in step S400 every square metre smear the obtained medical dressing of 300-600 milliliter step S300.
In addition, the dressing paste of the embodiment of the present invention has the second district 242 being positioned at center and the first district 241 surrounding this secondth district, and carry out step S500 in this secondth district 242: the medical dressing smearing 200-400 milliliter step S300 obtained with every square metre in the second district 242 proceeds to smear or spray, and make treatment layer dry.
Except having identical with general adhesive bandage compressing by physics except the hemostasia effect that reaches, also have by promoting that the function of coagulation process is accelerated in the formation of thrombokinase according to the dressing paste of the embodiment of the present invention.
Can avoid occurring wound infection according to the dressing paste of the embodiment of the present invention, easy to use.Owing to having stronger anti-infection ability, it is comparatively large or compared with the treatment of gash that it can also be used for wound surface.
Due to the effect of the dressing of the embodiment of the present invention, at the water gel available protecting nerve ending that wound surface is formed, avoid the stimulation of outer bound pair wound surface, eliminate damage, so cicatrization is few.On the other hand, due to water gel not easily with wound adhesion, so be easy to remove after wound healing, reduce wound pain.Therefore, do not need additionally to add sealing coat of the prior art, simplify production technology.
In one embodiment, be the mixture that spirulina and extract thereof and Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Mel, Radix Notoginseng obtain through bubble boiling for the preparation of the dressing of dressing paste.In addition, other architectural feature of this dressing paste is roughly the same with the individual features of the dressing paste shown in Fig. 1, does not repeat them here.
Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis and Mel have bactericidal antiphlogistic effect, to resist pathogenic microorganism and pathogenic microbe killing, promote growth and the reparation of damaged blood vessels neurocyte, and recover the vigor of subcutaneous capillary cell.Radix Notoginseng and Folium Nelumbinis have the effect of hemostasis removing heat from blood, can reduce and ooze out, ease the pain, and promote wound healing, protect from infection.Radix Notoginseng also has the effect of pain relieving and detumescence.
Due in this dressing containing the medicine possessing bactericidal antiphlogistic function, so wound can be repaired in time, accelerating wound.Like this, the dressing paste utilizing this medicine carrying dressing to make disposablely can complete the wrapping of infected wound, protection and treatment.
Moreover general adhesive bandage can not be used for the treatment of scald, burn, in order to avoid there is suppurative infection.According to the dressing paste of the present embodiment, improving microcirculation by selecting the appropriate proportioning of component of dressing to reach, promoting tissue regeneration, the multiple effect of antiinflammatory and acceleration ulcer healing, can be used in scalding and the treatment of burn.
Fig. 1 is the top view of the dressing paste according to one embodiment of the present invention.Fig. 2 is the profile of dressing paste shown in Fig. 1 along A-A ' line.This dressing paste comprises basic unit 11 stacked successively, adhesive layer 12, absorbed layer 13 and containing the treatment layer 14 of dressing comprising spirulina and/or its extract.Except spirulina and/or its extract, dressing can also comprise the additives such as cosolvent.As shown in Figure 2, absorbed layer 13 is positioned at the centre position of adhesive layer 12, and treatment layer 14 is positioned on absorbed layer 13, and its length can be equal, or absorbed layer 13 and treatment layer 14 specific adhesion layer 12 narrow.
The material of basic unit 11 can be the one in non-woven fabrics, PVC film with holes and spandex fabric.The material of adhesive layer 12 can be the one in pressure sensitive adhesive, PUR and adhesive sticker.The material of absorbed layer 13 can be non-woven fabrics or modification Absorbable rod azelon fabric.The extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide and ion.
Such as, the manufacture method of this dressing paste can be as follows: adopt injection or running roller method adhesive sticker uniform spreading to be located at the surface of the basic unit 11 that PCV film with holes is formed, to form adhesive layer 12; The non-woven fabrics of suitable size is placed in the center, surface of adhesive layer 12, to form absorbed layer 13; Dressing of the present invention to be coated on absorbed layer 13 and to carry out drying, thus forming treatment layer 14.Spirulina and extract thereof can be prepared according to the technology of existing technology or exploitation in the future, and at this, description is omitted.Although depict each functional layer in a layered fashion in the drawings, those skilled in the art can easily know, some or all ofly can permeate, combines, overlapping between each layer.Such as, treatment layer 14 has a little microbedding infiltration in absorbed layer 13.Other layers can have interpenetrative like this structure equally.
Fig. 3 is the top view of the dressing paste according to another embodiment of the present invention.Fig. 4 is the profile of dressing paste shown in Fig. 3 along B-B ' line.This dressing paste comprises basic unit 21 stacked successively, adhesive layer 22, absorbed layer 23 and containing the treatment layer 24 of dressing comprising spirulina and extract thereof.Except spirulina and extract thereof, dressing can also comprise the additives such as cosolvent.As shown in the figure, absorbed layer 23 and treatment layer 24 are positioned at the centre of adhesive layer 22, and the length for the treatment of layer 24 is less than or equal to the length of absorbed layer 23.Treatment layer 24 comprises first district 241 and second district 242 with different dressing concentration.
The material of basic unit 21 can be the one in non-woven fabrics, PVC film with holes and spandex fabric.The material of adhesive layer 22 can be the one in pressure sensitive adhesive, PUR and adhesive sticker.The material of absorbed layer 23 can be non-woven fabrics or modification Absorbable rod azelon fabric.The extract of spirulina comprises phycocyanin, chlorophyll, active substance, polysaccharide and ion.
Equally, although depict each functional layer and functional area with the form of layering and zoning in the drawings, but those skilled in the art can easily know, some or all ofly can permeate, combine, overlapping between each layer, each district can have different shapes and size.Such as, treatment layer 24 has a little microbedding infiltration in absorbed layer 23.Other layers can have interpenetrative like this structure equally.
As shown in Figure 3, the first district 241 is oval ring, and the second district 242 is oval, and they are symmetrical about the centrage one-tenth of this treatment layer.In other embodiments, can form that its shape is annulus, the firstth district of Q-RING, rhombus ring etc. and there is the secondth district of circle, square, rhombus or other suitable shape.
Such as, the manufacture method of this dressing paste can be as follows: adopt injection or running roller method adhesive sticker uniform spreading to be located at the surface of the basic unit 21 that PCV film with holes is formed, to form adhesive layer 22; The non-woven fabrics of applicable wound area size is arranged in the center, surface of adhesive layer 22, to form absorbed layer 23; Drying is carried out on the surface except the peripheral part dressing comprising spirulina and extract thereof being sprayed on absorbed layer 23, then this dressing be again sprayed on absorbed layer 23 be positioned at central authorities region on and carry out drying, thus forming the treatment layer 24 comprising the first district 241 and the second district 242, the dressing content in such second district 242 is just greater than the first district 241.Dressing can also be coated on absorbed layer by additive method by those skilled in the art, such as, smears the dressing of variable concentrations respectively in different field.Spirulina and extract thereof can be prepared according to the technology of existing technology or exploitation in the future, and at this, description is omitted.
About the treatment layer 24 completed, the second district 242 being positioned at central authorities preferably comprises spirulina and the extract thereof of more high-load compared to the first district 241 of periphery, thus the position being conducive to directly contacting with wound forms gelatinous protecting film quickly.
In one embodiment, be the mixture that spirulina and extract thereof and Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Mel, Radix Notoginseng are formed for the preparation of the dressing of dressing paste.In addition, other architectural feature of this dressing paste is roughly the same with the individual features of the dressing paste shown in Fig. 2, does not repeat them here.
Such as, the manufacture method of this dressing paste can comprise: make the first mixed solution based on aforesaid step S100, S200, S300; The second mixed solution is made based on the step similar with aforesaid step S100, S200, S300, wherein the weight of Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng is correspondingly lower than the weight of the Chinese medicine of the same race adopted during making the first mixed solution, and the weight of spirulina and/or spirulina extract will correspondingly higher than the weight of the spirulina adopted during making the first mixed solution and/or spirulina extract; First and second mixed solutions are sprayed on firstth district corresponding respectively to the treatment layer that will be formed of absorbed layer (such as respectively, the first district 241 in Fig. 3) and the secondth district is (such as, the second district 242 in Fig. 3) region on and carry out drying, thus formed treatment layer.
Preferably, be sprayed on content corresponding to spirulina and extract thereof in the first mixed solution on the region in the firstth district lower than the content be sprayed on corresponding to spirulina and extract thereof in the second mixed solution on the region in the secondth district, the position being beneficial to directly contact with wound forms gelatinous protecting film quickly; And the content be sprayed on corresponding to the above-mentioned Chinese medicine in the first mixed solution on the region in the firstth district is higher than the content be sprayed on corresponding to these Chinese medicines in the second mixed solution on the region in the secondth district, to strengthen the effects such as sterilization, pain relieving.
Due in this dressing containing the medicine possessing bactericidal antiphlogistic function, so wound can be repaired in time, accelerating wound.Like this, the dressing paste utilizing this medicine carrying dressing to make disposablely can complete the wrapping of infected wound, protection and treatment.
According to the embodiment of the present invention, provide there is hemostasis, promote wound healing, sterilization, antibacterial, the medical dressing and the dressing paste that reduce the treatment functions such as pain.Because the coating pharmaceutical products adopted all adopts natural extract material, natural materials, Chinese herbal medicine etc., thus its to human body be safety, ecological, environmental protective and having no side effect.
The experiment effect of above-mentioned dressing and dressing paste is below described by an embodiment again:
Example 2:
In March ,-2013 in March, 2012 at the shallow table abscess 65 Cases of Patients of Low Potassium of certain hospital admission, age 18-65 year, wound surface or otch≤2.Get rid of and suffer from diabetes, tuberculosis, allergic constitution person.Position 2, the identity recognition number end figure place adopting first visit to register is divided into spirulina dressing paste group 33 example and traditional group 32 example at random divided by the method for 2.
After otch routine disinfection, the capable local anesthesia of 2% lidocaine hydrochloride, cuts along abscess major diameter, and to focus edge, remove the inner slough of abscess and pus, fill vaseline gauze cloth in otch, operation wrapped up by external use sterile gauze.Start next day to change dressings, the next day 1 time.Cover otch with spirulina dressing when spirulina dressing group is changed dressings, cover wound with common dressing when traditional group is changed dressings, until wound healing.Healing time be from from Abscess incision to the required natural law of otch recovery from illness.
Respectively in the sepage situation at assessment in the 1st, 3,7 day 2 groups of patient incision positions, within the 21st day, do efficacy evaluation, pain degree, wound healing situation when record is changed dressings.The assessment of sepage amount and score: estimate sepage amount according to the infiltration situation of dressing and select corresponding score value.Dry without sepage meter 0 point, within 24 hours, sepage <5ml is a small amount of meter 1 point, and 5-10ml is middle gauge 2 points, and >=10ml is large gauge 3 points.
The sepage amount difference not statistically significant of 2 groups of patients the 1st day cutting part, the sepage amount spirulina dressing group of the 3rd, 7 day cutting part is less than traditional group; Pain degree average when spirulina dressing group is changed dressings is lower than traditional group, and healing time is shorter than traditional group, in table 2.The total effective rate of 2 groups of patients is 100%, has no adverse reaction.The therapeutic evaluation in the 21st day of spirulina group is better than traditional group, in table 3.
The sepage situation at table 2,2 groups of patient incision positions, pain degree and healing time compare
*P<0.05，**P<0.01
The comparison [example (%)] of table 3,2 groups of patients therapeutic evaluation in the 21st day
| Group | n | Recovery from illness | Effective | Take a turn for the better | Invalid |
| Spirulina group | 33 | 24（72.7%） | 7（21.2%） | 2（6.1%） | 0 |
| Traditional group | 32 | 14（43.8%） | 10（31.3%） | 8（25.0%） | 0 |
Z=2.542，P<0.05
Make dressing paste, spirulina or extract interpolation Chinese medicine ingredients owing to having selected pure spirulina or extract and make dressing paste, find that adding Chinese medicine ingredients makes dressing paste, than be separately the dressing paste made with spirulina or extract suppression microorganism, reduce in pain more obvious.The spirulina selected due to the embodiment of the present invention and extract, Chinese crude drug, Mel etc. are all the natural materials not carrying out any artificial interpolation or change, so effectively can ensure that its effective ingredient is all from above-mentioned material itself.
Due to the Thief zone effect of effective ingredient in the dressing of spirulina group, can aspirates tissue transudate, keep otch dry, reduce tissue edema, avoid skin maceration, be conducive to wound healing.This studies the sepage amount difference not statistically significant of 2 groups of patients the 1st day cutting part, and change dressings the 3rd day and the 7th day, the sepage amount of spirulina group cutting part is less than traditional group.
Moisture treatment is that Britain Jorge doctor Winter proposed in 1962, and it is defined as and uses various wet union dressing (or maintenance otch appropriateness is moistening), promotes cell changes and growth, is beneficial to the method for wound healing.Although moisture is few in spirulina dressing paste, but it provides a wet environment for healing, he is by ion exchange and admittedly lock avoiding causing and organizing hydropenia of water effective, for otch builds the healing environment of the appropriate moistening and micro-acid of hypoxia, promotes the growth of new granulation tissue.This research spirulina group Abscess incision patient applies spirulina dressing paste, and the curative effect of the 21st day is better than traditional group, and healing time is shorter than traditional group.
This result of study prompting spirulina dressing posts and significantly suppresses microorganism, reduces and bear, create the moist environment being conducive to tissue growth, accelerate wound healing, effectively alleviate wound pain degree, promoting granulation tissue growth etc., is one new method safely and effectively.
The above is only exemplary embodiment of the present invention, but not for limiting the scope of the invention, protection scope of the present invention is determined by appended claim.
Should be understood that, above-mentioned detailed description of the invention of the present invention only for exemplary illustration or explain principle of the present invention, and is not construed as limiting the invention.Therefore, any amendment made when without departing from the spirit and scope of the present invention, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.In addition, claims of the present invention be intended to contain fall into claims scope and border or this scope and border equivalents in whole change and modification.
Claims (5)
1. a medical dressing, comprise spirulina and spirulina extract, wherein spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin, it is multiple that described ion comprises in calcium ion, copper ion, iron ion, zinc ion, phosphonium ion, magnesium ion, potassium ion, it is multiple that described vitamin comprises in vitamin A, C, E, B1, B2, B6, B12
Wherein, described dressing is mixed with the liquid that following Traditional medicine bubble obtains: the Chinese medicine with bactericidal antiphlogistic effect, the Chinese medicine with anastalsis, have analgesic effect Chinese medicine and/or there is the Chinese medicine of detumescence effect, promote the Chinese medicine of wound healing or promoting muscle growth functions, it is multiple that described Chinese medicine comprises in Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, Radix Notoginseng, described dressing contains Mel, it is characterized in that, described dressing obtains according to following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly.
2. a medical dressing manufacture method, is characterized in that comprising the following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly and obtain medical dressing, wherein spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin.
3. a manufacture method for dressing paste, is characterized in that comprising the following steps:
Step S100: by Cortex Phellodendri, Radix Rumicis Japonici, Radix Sophorae Flavescentis, Flos Chrysanthemi Indici, Folium Isatidis, Folium Nelumbinis, each 10-20 of Radix Notoginseng gram with water 3000-6000 milliliter boil latter lasting 20-60 minute for subsequent use;
Step S200: temperature drops to when 20-40 spends and correspondingly takes out 1500-3000 milliliters of liquid;
Step S300: spirulina and spirulina extract 80-150 gram, Mel 50-100 gram are added above-mentioned 1500-3000 milliliters of liquid and stir evenly and obtain medical dressing, wherein spirulina extract comprises phycocyanin, chlorophyll, superoxide dismutase, polysaccharide, ion and vitamin;
Step S400: spread upon equably on the absorbed layer of dressing paste by described medical dressing, forms treatment layer.
4. method as claimed in claim 3, is characterized in that smearing the obtained medical dressing of 300-600 milliliter step S300 for every square metre in step S400.
5. method as claimed in claim 3, it is characterized in that: described dressing paste has the secondth district being positioned at center and the firstth district surrounding this secondth district, and carry out step S500 in described secondth district: proceed to smear or spray with the medical dressing that every square metre of 200-400 milliliter step S300 is obtained on the second region, and make described treatment layer dry.
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| CN110124087B (en) * | 2019-06-10 | 2021-01-26 | 江苏农林职业技术学院 | Preparation method of band-aid based on flavonoid active ingredients in tassel leaves |
| CN112999403A (en) * | 2021-03-01 | 2021-06-22 | 中国科学院烟台海岸带研究所 | Preparation method of oral cavity repairing film |
| CN114288459A (en) * | 2021-12-06 | 2022-04-08 | 山东速康医疗科技有限公司 | Preparation method of medical silicone foam dressing |
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