CN104307032B - A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing - Google Patents
A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing Download PDFInfo
- Publication number
- CN104307032B CN104307032B CN201410616668.9A CN201410616668A CN104307032B CN 104307032 B CN104307032 B CN 104307032B CN 201410616668 A CN201410616668 A CN 201410616668A CN 104307032 B CN104307032 B CN 104307032B
- Authority
- CN
- China
- Prior art keywords
- liquid dressing
- alginate
- antibacterial
- pain relieving
- wound healing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention relates to a kind of formula of liquid dressing and preparation method that there is pain relieving, antibacterial, hemostasis and wound healing can be promoted, this Auxiliary Liquid Material is with water as solvent, and natural tea tree quintessence oil, allantoin, alginate, Hyaluronic Acid, gelatin, Polyethylene Glycol, glycerol, vitamin E are principle active component.The present invention has obvious inhibitory activity to the growth of multiple pathogen, to staphylococcus aureus, escherichia coli, Candida albicans killing rate up to 99%.And to skin and mucosa nonirritant, have the effect of pain relieving, hemostasis concurrently, it is adaptable to skin and the treatment of mucosa traumatic infection, and the healing of wound can be promoted.
Description
Technical field
The present invention relates to a kind of formula of liquid dressing and preparation method that there is pain relieving, antibacterial, hemostasis and wound healing can be promoted, this Auxiliary Liquid Material is with water as solvent, and natural tea tree quintessence oil, allantoin, alginate, Hyaluronic Acid, gelatin, Polyethylene Glycol, glycerol, vitamin E are principle active component.The present invention has obvious inhibitory activity to the growth of multiple pathogen, to staphylococcus aureus, escherichia coli, Candida albicans killing rate up to 99%.And to skin and mucosa nonirritant, have the effect of pain relieving, hemostasis concurrently, it is adaptable to skin and the treatment of mucosa traumatic infection, and the healing of wound can be promoted.
Technical background
People cause the various damages of human body skin to be inevitable in daily life and work, mainly include skin and the damage of mucosa wound surface.Add up according to World Health Organization (WHO), the nineteen ninety whole world lethal number of various wounds about 5,100,000 people.Showing according to health ministry statistical data, within 2005, wound is the 5th cause of the death in China city and rural area, accounts for the 6.17% of total death toll.The method treating wound on market mainly has powdery type medicine, adhesive bandage, ointments medicine and Auxiliary Liquid Material etc..The zest of wound surface is solved by current medicine the most substantially, but there is the water proofing property of medicine and breathability is poor, biocompatibility and the problem such as degradability is not ideal enough.The invention provides a kind of antibacterial, hemostasis and the liquid dressing of wound healing can be promoted, after this liquid dressing imposes on wound, there is analgesic hemostatic effect, and wound healing can be promoted, do not stay scar.
The present invention is main antibacterial with natural tea tree quintessence oil.Natural tea tree quintessence oil is by a kind of plants essential oil extracted in plant Melaleuca Alternifolia, has good antibacterial effect, all has staphylococcus aureus, escherichia coli and Candida albicans and good kills ability.The slow vaporization and tea tree ethereal oil tool protection skin effect is eased up, is possible not only to protection after imposing on affected part and skin care may also operate as long-acting effect, and sterilization drug effect can maintain 24 hours,.
Alginate is that brown seaweed processes, through refining, the natural macromolecular material obtained, and has hemostasis and promotes wound healing and the effect of skin regeneration.Calcium ion in alginate can displace the sodium ion in wound exudate, makes insoluble calcium alginate be converted into the sodium alginate of solubility.Sodium alginate has an ability absorbing big quantity of fluid, and after absorbing sepage, sodium alginate forms one layer of stable sodium alginate network gel in wound surface, makes wound surface maintain a moistening environment, thus beneficially wound healing and skin regeneration.It is dissolved in sepage after biodegradation, can completely strip, and fiber does not ends up on wound surface, and the calcium ion cemented out condenses in a large number in wound surface and can accelerate wound surface hemostasis.
Allantoin is the derivant of uric acid, fairly obvious to the Healing of skin.Tissue can be promoted to produce natural debridement effect, remove downright bad material；Cell proliferation can be obviously promoted, make rapidly granulation tissue grow up, shorten healing time.After applicating liquid dressing, it is possible not only to alleviate wound pain, the most good antiinflammation, strengthens healing effect.
Hyaluronic Acid is a kind of acid mucopolysaccharide, first isolates this material from bovine vitreous body.Hyaluronic Acid demonstrates multiple important physiological function with molecular structure and the physicochemical property of its uniqueness in body, such as lubricating joint, the permeability of regulation blood vessel wall, regulates protein, Water-Electrolyte diffusion and operating, promotes wound healing etc..Hyaluronic Acid is a kind of multi-functional substrate, and it can improve skin-nourishing metabolism, makes that skin is tender, smooth, wrinkle removing, increase is elastic, prevent aging, is again good Percutaneous absorption enhancer while moisturizing.
Gelatin has hemostasis and promotes the function of wound healing, and in the present invention in addition to applying its effect, gelatin and Polyethylene Glycol, as a kind of thickening agent, slow down the volatilization of natural tea tree quintessence oil.Glycerol and vitamin E are used for increasing the affinity of liquid dressing and wound surface, make liquid dressing preferably act on wound surface, play pain relieving, hemostasis, the antibacterial and effect of promotion wound healing.When this Auxiliary Liquid Material is applied to skin surface, one layer of liquid film can be formed at skin surface, there is no uncomfortable sensation, there is the effect of pain relieving, and waterproof and dustproof can be played, stop the effects such as microorganism invasion, and healthy skin is also had certain skin effect.As time went on, Auxiliary Liquid Material can slowly volatilize, degrade, and leaves no trace.
Based on the respective physiologically active of above-mentioned substance, the present invention by its compatibility, to prepare a kind of pain relieving, hemostasis, antibacterial and promote the liquid dressing of wound healing, serves extensive patients.
Summary of the invention
It is an object of the invention to provide a kind of pain relieving, antibacterial, stop blooding and promote the formula of liquid dressing and the preparation method of wound healing.The liquid dressing that the present invention provides has broad spectrum antibacterial, growth to multiple pathogen has obvious inhibitory activity, to staphylococcus aureus, escherichia coli, Candida albicans sterilization rate up to 99%, and to skin and mucosa nonirritant, it is adaptable to skin and the treatment of mucosa traumatic infection.In addition, the present invention also has analgesic hemostatic effect, can make wound healing, and keep the smooth and fine and smooth of skin.
Technical scheme is as follows:
1, a kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing, it is characterised in that with natural tea tree quintessence oil, allantoin, alginate, Hyaluronic Acid, gelatin, Polyethylene Glycol, glycerol, vitamin E as principle active component.
2, foregoing liquid dressing, it is characterised in that the content of alginate is 0.01-1%, described alginate can be one or more mixing in sodium alginate, potassium alginate, calcium alginate, ammonium alginate.
3, foregoing liquid dressing, it is characterised in that alginate can be high M type, high G type or MG mixed type.
4, foregoing liquid dressing, it is characterised in that the content of tea tree ethereal oil is at 0.01%-3%.
5, foregoing liquid dressing, it is characterised in that the content of allantoin is at 0.01-0.1%.
6, foregoing liquid dressing, it is characterised in that the content of Hyaluronic Acid is at 0.01-5%.
7, foregoing liquid dressing, it is characterised in that the consumption of gelatin is 0.1-1%.
8, foregoing liquid dressing, it is characterized in that, allantoin, alginate, Hyaluronic Acid, gelatin, Polyethylene Glycol are weighed up by formula ratio, is dissolved in water, drip the tea tree ethereal oil of formula ratio and appropriate glycerol and vitamin E again, remix and be settled to required volume.
Detailed description of the invention
Embodiment 1:
Taking in the beaker of allantoin 0.1g, alginate 2g, Hyaluronic Acid 1g, gelatin 1g, Polyethylene Glycol 10g to 1L, the 500mL that adds water dissolves, then adds tea tree ethereal oil 0.1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, fill, radiation sterilization,.
Embodiment 2:
Taking in the beaker of allantoin 0.2g, alginate 5g, Hyaluronic Acid 2g, gelatin 0.5g, Polyethylene Glycol 5g to 1L, the 500mL that adds water dissolves, then adds tea tree ethereal oil 1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, fill, radiation sterilization,.
Embodiment 3:
Taking in the beaker of allantoin 0.3g, alginate 0.5g, Hyaluronic Acid 0.5g, gelatin 0.5g, Polyethylene Glycol 5g to 1L, the 500mL that adds water dissolves, then adds tea tree ethereal oil 1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, fill, radiation sterilization,.
Claims (5)
1. a pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing, it is characterised in that take allantoin 0.1g, alginic acid
Salt 2g, Hyaluronic Acid 1g, gelatin 1g, Polyethylene Glycol 10g to 1L beaker in, the 500mL that adds water dissolve, then add Camellia sinensis essence
Oil 0.1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, fill, radiation sterilization, i.e. make
Obtain described liquid dressing.
2. a pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing, it is characterised in that take allantoin 0.2g, alginic acid
Salt 5g, Hyaluronic Acid 2g, gelatin 0.5g, Polyethylene Glycol 5g to 1L beaker in, the 500mL that adds water dissolve, then add Camellia sinensis essence
Oil 1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, fill, radiation sterilization, the most prepared
Described liquid dressing.
3. a pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing, it is characterised in that take allantoin 0.3g, alginic acid
Salt 0.5g, Hyaluronic Acid 0.5g, gelatin 0.5g, Polyethylene Glycol 5g to 1L beaker in, the 500mL that adds water dissolves, then adds Camellia sinensis
Quintessence oil 1g, glycerol and vitamin E mix in right amount, add water and supply volume, after stirring, and fill, radiation sterilization, i.e. make
Obtain described liquid dressing.
4. the liquid dressing described in any one of claim 1-3, it is characterised in that described alginate selected from sodium alginate, potassium alginate,
One or more in calcium alginate, ammonium alginate.
5. the liquid dressing described in any one of claim 1-3, it is characterised in that described alginate is selected from high M type, high G type
Or MG mixed type.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410616668.9A CN104307032B (en) | 2014-11-05 | 2014-11-05 | A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410616668.9A CN104307032B (en) | 2014-11-05 | 2014-11-05 | A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104307032A CN104307032A (en) | 2015-01-28 |
| CN104307032B true CN104307032B (en) | 2016-11-16 |
Family
ID=52362432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410616668.9A Active CN104307032B (en) | 2014-11-05 | 2014-11-05 | A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104307032B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105709273B (en) * | 2016-04-08 | 2018-08-31 | 杭州吉为医疗科技有限公司 | A kind of liquid medical dressing containing polyethylene glycol |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104997591A (en) * | 2015-08-24 | 2015-10-28 | 泰州市榕兴医疗用品股份有限公司 | Vitamin E gel dressing |
| CN106619823A (en) * | 2016-10-14 | 2017-05-10 | 柳州环山科技有限公司 | Ointment for therapy of eczema and preparation method of same |
| CN106377793A (en) * | 2016-11-16 | 2017-02-08 | 广东泰宝医疗科技股份有限公司 | Compound liquid dressing and preparation method thereof |
| CN107252456A (en) * | 2017-06-09 | 2017-10-17 | 成都珂萝瑞诗化妆品有限公司 | A kind of swelling reducing and pain easing gel and preparation method thereof |
| CN107670098A (en) * | 2017-11-28 | 2018-02-09 | 苏州汇涵医用科技发展有限公司 | A kind of wound healing liquid dressing and preparation method thereof |
| CN107670099A (en) * | 2017-11-28 | 2018-02-09 | 苏州汇涵医用科技发展有限公司 | A kind of liquid dressing and preparation method thereof |
| CN108635618B (en) * | 2018-08-01 | 2021-08-20 | 浙江派菲特新材料科技有限公司 | Preparation method of medical adhesive with healing promoting and repairing functions |
| CN108969795B (en) * | 2018-08-29 | 2019-09-10 | 海南一鸿实业发展有限公司 | One kind is for difficult healedmyocardial surface of a wound functional liquid dressing and preparation method thereof |
| CN112107724A (en) * | 2019-06-21 | 2020-12-22 | 西安博和医疗科技有限公司 | Liquid dressing and preparation method thereof |
| CN111012944A (en) * | 2019-12-30 | 2020-04-17 | 山东星之诚生物科技有限公司 | Liquid dressing based on alginate and hyaluronic acid and preparation method thereof |
| CN112057670A (en) * | 2020-09-30 | 2020-12-11 | 贯皓医疗科技(惠州市)有限公司 | Liquid dressing for wound |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100423785C (en) * | 2004-11-16 | 2008-10-08 | 周广刚 | Liquid dressing |
| CN1739808A (en) * | 2005-07-25 | 2006-03-01 | 周广刚 | Liquid dressing |
| CN103083713B (en) * | 2012-12-10 | 2015-12-23 | 江苏华亿细胞组织工程有限公司 | A kind of aseptic polymerization wound-surface cover dressing |
| CN103301501B (en) * | 2013-06-18 | 2015-05-06 | 王珍 | Medical liquid dressing and preparation method thereof |
| CN103341203B (en) * | 2013-06-24 | 2015-04-22 | 张延海 | Medical dressing, preparation method of medical dressing and preparation method of dressing plaster |
-
2014
- 2014-11-05 CN CN201410616668.9A patent/CN104307032B/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105709273B (en) * | 2016-04-08 | 2018-08-31 | 杭州吉为医疗科技有限公司 | A kind of liquid medical dressing containing polyethylene glycol |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104307032A (en) | 2015-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104307032B (en) | A kind of pain relieving, antibacterial, stop blooding and promote the liquid dressing of wound healing | |
| CN106334067B (en) | Gynecological gel containing silver ion antibacterial agent, preparation method and application | |
| US20070098671A1 (en) | Composition and method of treatment for irritated skin | |
| CN102949709B (en) | External gel used for treating diabetic foot, and preparation method and application thereof | |
| CN105107007B (en) | A kind of medical protective dressing of cation and preparation method thereof | |
| US20100284951A1 (en) | Novel compositions for the treatment of wounds and skin care | |
| US20080145461A1 (en) | Formulation and method of making a topical pain relief composition | |
| CN102133340A (en) | Chinese herbal wound and burn patch for external use and preparation method thereof | |
| CN106963837A (en) | Skin trauma nursing essential oil and its preparation method and application | |
| CN105749331A (en) | Salvia sclarea wound dressing and preparation method thereof | |
| RU2381810C1 (en) | Wound healing gel balm | |
| AU2015217576A1 (en) | Nasal and sinus wash compositions and methods | |
| CN107669734A (en) | Antibacterial cream of skin and preparation method thereof | |
| CN107596355A (en) | A kind of Medical pain easing, the exterior-applied gel subsided a swelling, brought down a fever and preparation method thereof | |
| CN106620652A (en) | Nano-ion antibacterial tissue regeneration promoting care solution and preparation method thereof | |
| CN102579537A (en) | Medicament for treating diabetic foot and deep ulcer | |
| CN103191163B (en) | Skin wound repairing pharmaceutical composition | |
| CN101837068B (en) | Preparation process of zanthoxylum oil spray and application thereof | |
| CN106955291B (en) | A kind of antibacterial anti-inflammatory medicament and preparation method thereof | |
| CN104382998A (en) | Carbomer gel and preparation method thereof | |
| CN104189940A (en) | Antibacterial liquid dressing containing chitosan hydrochloride and preparation method thereof | |
| CN107469038A (en) | A kind of emulsifiable paste for treating tinea pedis and preparation method thereof | |
| RU2807890C1 (en) | Hydrophilic composition for treatment of wounds of various etiologies based on juice of kalanchoe pinnate | |
| CN111700825B (en) | Oily composition for oral health care, preparation method and application thereof | |
| CN113230205B (en) | Gynecological gel preparation and preparation method and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20190118 Address after: Room 911-912, 5 blocks, Huadu Commercial Plaza, 288 Haoxi Road, Gangzha District, Nantong City, Jiangsu Province Patentee after: Nantong Tianshengda Trading Co., Ltd. Address before: No. 399 Bingshui Road, Xiqing District, Tianjin, Tianjin Patentee before: Tianjin Polytechnic University |