CN107669734A - Antibacterial cream of skin and preparation method thereof - Google Patents
Antibacterial cream of skin and preparation method thereof Download PDFInfo
- Publication number
- CN107669734A CN107669734A CN201710942004.5A CN201710942004A CN107669734A CN 107669734 A CN107669734 A CN 107669734A CN 201710942004 A CN201710942004 A CN 201710942004A CN 107669734 A CN107669734 A CN 107669734A
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- Prior art keywords
- skin
- antibacterial cream
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- antibacterial
- cream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to field of medicaments, more particularly to antibacterial cream of a kind of skin and preparation method thereof.The raw material that the antibacterial cream of skin includes following parts by weight is formed：2.0 10 parts of 3.0 9.5 parts of Blumea oil, 2.0 10 parts of peppermint oil, medicinal alcohol or the medicinal alcohol aqueous solution, 1.0 2.5 parts of carbomer resin, 1.5 4.5 parts of triethanolamine, 1.5 4.5 parts of nonionic emulsifier.The present invention also provides a kind of preparation method of the antibacterial cream of skin.Blumea oil, peppermint oil and medicinal alcohol all have the function that sterilizing in the present invention, can effectively kill the bacterium except skin surface.Simultaneously as Blumea oil can warming and activating meridian, the expansible pore of peppermint oil and blood vessel, Blumea oil and peppermint oil all possess the effect for helping effective sterilization component to penetrate into skin, so as to strengthen the drug effect of the present invention, ensure lasting medicine.
Description
Technical field
The present invention relates to field of medicaments, more particularly to antibacterial cream of a kind of skin and preparation method thereof.
Background technology
Skin infection and cutaneous lesions can all cause skin disease, and wherein skin disease caused by skin infection is more common.Skin
Skin infection is mainly caused by bacterium or fungi, such as staphylococcus aureus, Escherichia coli and Candida albicans etc..Therefore, skin
It is general using sterilization, antibacterial treatment method in dermopathic clinical treatment caused by skin infection.Existing disinfection skin
In medicine, mainly antibacterial constituents, such as the western patent medicine such as chlorohexidene are used.But these Western medicine bacteriostatics have irritation effect,
Be not suitable for sensitive.In order to solve the above problems, one of ordinary skill in the art using Chinese medicine sterilizing composition substitute Western medicine into
Point, such as chrysanthemum indicum, barberry, gleditsia sinensis etc., so as to reduce the excitant of bacteriostatic.Although the sterilization skin of these traditional Chinese medicine ingredients
Skin medicine excitant is low, but the persistence of drug effect is low.
The content of the invention
It is an object of the invention to provide a kind of antibacterial cream of skin, using traditional Chinese medicine ingredients, reduces its excitant, and utilize folium artemisiae argyi
Acted on the dredging collateral of peppermint, improve its lasting medicine.
In order to achieve the above object, the antibacterial cream of skin provided by the invention, in parts by weight, including：
The present invention is using Blumea oil and peppermint oil as main component.Blumea oil has antibacterial, antiviral, hemostasis work(
Effect, external application also can warming and activating meridian, the promoting flow of qi and blood circulation.Peppermint oil has the function that to sterilize antibacterial, is irritating to the skin effect, can cause
Pore is expanded, and deep vessels change, helps other active ingredients to penetrate into skin.
In order to further improve bactericidal effect, the present invention also added alcohol or its aqueous solution.In view of the stimulation of alcohol
Property, it is preferred to use percent by volume is 50% alcohol water blend.In general, alcohol concentration need to reach 75% (volume) can
With bactericidal effect, but inventor is had found by many experiments, is coordinating the premise of this composition in two of Blumea oil and peppermint oil
Under, using the alcohol of low concentration as aid antibacteria agent, it becomes possible to play effective sterilization, bacteriostasis, and will not be because of
A large amount of uses of alcohol cause strong impulse sense to patient.Meanwhile alcohol can promote local blood circulation, contribute to effectively into
Divide and go deep into skin.
Carbomer resin is the polyacrylic acid of crosslinking, is widely used as dispersion stabilizer in the art and thickening thickens
Agent；Carbomer resin and triethanolamine are used cooperatively in the present invention, using crosslinked action of the latter to the former, in carbomer tree
In the case of fat usage amount very little, effective thick stabilization effect is can be achieved with, active ingredient in antibacterial cream is improved and contains relatively
Amount.Meanwhile there is certain moisture-keeping function, moist antipruritic effect can be played.Further, it is preferable to use carbomer resin
940。
The effect of nonionic emulsifier is further to promote the active ingredient of oil phase and dissolving each other for water-phase component, improved
The stability of antibacterial cream.The selection of nonionic emulsifier has no particular limits, as long as it can be used for pharmaceuticals in this area
Emulsifying agent can be used；It is preferred that using Span series, further preferably Span 80 is used.
Further, PVP 50-100 parts can be also contained in the antibacterial cream of skin of the invention.Polyethylene
Base pyrrolidones can further improve lotion viscosity, change the rheological behavior of lotion as supplementary thickener；Polyethylene simultaneously
Base pyrrolidones is non-stimulated to skin, eyes, can strengthen the moistening and lubricant effect of lotion.
Further, preservative 0.03-0.17 parts can be also contained in the antibacterial cream of skin of the invention.Choosing for antiseptic
Select and be not particularly limited, as long as the antiseptic in this area available for medical material can be used.It is preferred that use nipagin esters.
Further, food coloring 0.01-0.07 parts can be also contained in the antibacterial cream of skin of the invention.
The present invention also provides the preparation method of the antibacterial cream of skin, comprises the following steps：
S1, carbomer resin mixed with purified water, carbomer resin is fully dissolved；
S2, Blumea oil, peppermint oil, medicinal alcohol or the medicinal alcohol aqueous solution, nonionic emulsifier be well mixed；
S3, the mixture of S1 mixture and S2 is well mixed；
S4, triethanolamine is added into S3 mixture, stirred, stood solidification, obtain the antibacterial cream of skin.
Further, the preparation method be additionally included in S2 or S3 steps add PVP, preservative,
One or more steps of food coloring.
Further, the preparation method also includes：
S5, by the antibacterial cream of S4 skin it is filling, sterilizing and packaging operation.
Beneficial effects of the present invention are：
Blumea oil, peppermint oil and medicinal alcohol all have the function that sterilizing, can effectively kill except skin surface
Bacterium.Simultaneously as Blumea oil can warming and activating meridian, the expansible pore of peppermint oil and blood vessel, Blumea oil and peppermint oil all possess
Help effective sterilization component to penetrate into the effect of skin, so as to strengthen the drug effect of the present invention, ensure lasting medicine.Polyvinyl pyrrole
Pyrrolidone and triethanolamine improve the moisturizing of the present invention, moisturizing effect, play itching-relieving action.
Embodiment
Technical scheme will be clearly and completely described below, it is clear that described embodiment is only
Part of the embodiment of the present invention, rather than whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art
The every other embodiment obtained under the premise of creative work is not made, belongs to the scope of protection of the invention.
Embodiment 1
The formula and preparation method of the antibacterial cream of skin shown in the present embodiment are as follows：
S1,2.5g carbomer resins 940 are mixed with 50mL purified waters, carbomer resin 940 is fully dissolved；
S2,5g Blumea oils, 5g peppermint oils, 15g 15% (V/V) the medicinal alcohol aqueous solution, 3g Spans 80 mixed
It is even；
S3, the mixture of S1 mixture and S2 is well mixed；
S4,1.5g triethanolamines are added into S3 mixture, stirred, stood solidification, obtain the antibacterial cream of skin.This
Embodiment provides a kind of antibacterial cream of typical skin.
Embodiment 2
The formula and preparation method of the antibacterial cream of skin shown in the present embodiment are as follows：
S1,2.5g carbomer resins 940 are mixed with 20mL purified waters, carbomer resin 940 is fully dissolved；
S2,8g Blumea oils, 10g peppermint oils, 5g medicinal alcohols, 3g Spans 80 be well mixed；
S3, the mixture of S1 mixture and S2 is well mixed；
S4,1.5g triethanolamines are added into S3 mixture, stirred, stood solidification, obtain the antibacterial cream of skin.
Present embodiments provide a kind of specific enhancing fungistatic effect and the stronger antibacterial cream of skin of excitant.
Embodiment 3
On the basis of embodiment 1,50g PVPs are added in step s 2, other are the same as embodiment 1.
Present embodiments provide a kind of antibacterial cream of highly viscous skin.
Embodiment 4
On the basis of embodiment 1,50g PVPs are added in step s3, are added in step s 4
0.15g ethylparabens and 0.05g Tea Green Pigments, other are the same as embodiment 1.
The present embodiment provides a kind of apparent greeny antibacterial cream of skin.
The foregoing is only a specific embodiment of the invention, but protection scope of the present invention is not limited thereto, any
Those familiar with the art the invention discloses technical scope in, change or replacement can be readily occurred in, should all be contained
Cover within protection scope of the present invention.Therefore, protection scope of the present invention described should be defined by scope of the claims.
Claims (10)
1. the antibacterial cream of skin, it is characterised in that in parts by weight, including：
2. the antibacterial cream of skin according to claim 1, it is characterised in that the antibacterial cream of skin uses medicinal alcohol.
3. the antibacterial cream of skin according to claim 1, it is characterised in that the antibacterial cream of skin is cured using 50% (V/V)
Use alcohol water blend.
4. the antibacterial cream of skin according to claim 1, it is characterised in that the carbomer resin is carbomer resin 940.
5. the antibacterial cream of skin according to claim 1, it is characterised in that the nonionic emulsifier is Span 80.
6. the antibacterial cream of skin according to claim any one of 1-5, it is characterised in that also contain in the antibacterial cream of skin
PVP 50-100 parts.
7. the antibacterial cream of skin according to claim any one of 1-5, it is characterised in that also contain in the antibacterial cream of skin
Preservative 0.03-0.17 parts；The preservative is preferably nipagin esters.
8. the antibacterial cream of skin according to claim any one of 1-5, it is characterised in that also contain in the antibacterial cream of skin
Food coloring 0.01-0.07 parts.
9. the preparation method of the antibacterial cream of skin according to claim any one of 1-8, it is characterised in that including following step
Suddenly：
S1, carbomer resin mixed with purified water, carbomer resin is fully dissolved；
S2, Blumea oil, peppermint oil, medicinal alcohol or the medicinal alcohol aqueous solution, nonionic emulsifier be well mixed；
S3, the mixture of S1 mixture and S2 is well mixed；
S4, triethanolamine is added into S3 mixture, stirred, stood solidification, obtain the antibacterial cream of skin.
10. preparation method according to claim 9, it is characterised in that the preparation method is additionally included in S2 or S3 steps
Middle addition PVP, preservative, one or more steps of food coloring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710942004.5A CN107669734A (en) | 2017-10-11 | 2017-10-11 | Antibacterial cream of skin and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710942004.5A CN107669734A (en) | 2017-10-11 | 2017-10-11 | Antibacterial cream of skin and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107669734A true CN107669734A (en) | 2018-02-09 |
Family
ID=61140208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710942004.5A Pending CN107669734A (en) | 2017-10-11 | 2017-10-11 | Antibacterial cream of skin and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN107669734A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613823A (en) * | 2019-10-21 | 2019-12-27 | 王建武 | Traditional Chinese medicine composition for treating beriberi and bromhidrosis, preparation method thereof and medicine containing traditional Chinese medicine composition |
| CN113318163A (en) * | 2021-06-11 | 2021-08-31 | 俏福圣药业有限公司 | Formula for treating skin inflammation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269230A (en) * | 1999-04-05 | 2000-10-11 | 韩星温 | Chinese medicinal skin disinfectant |
-
2017
- 2017-10-11 CN CN201710942004.5A patent/CN107669734A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1269230A (en) * | 1999-04-05 | 2000-10-11 | 韩星温 | Chinese medicinal skin disinfectant |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613823A (en) * | 2019-10-21 | 2019-12-27 | 王建武 | Traditional Chinese medicine composition for treating beriberi and bromhidrosis, preparation method thereof and medicine containing traditional Chinese medicine composition |
| CN113318163A (en) * | 2021-06-11 | 2021-08-31 | 俏福圣药业有限公司 | Formula for treating skin inflammation |
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| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20180209 |
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| RJ01 | Rejection of invention patent application after publication |