CN113143992A - Skin antibacterial cream and preparation method thereof - Google Patents
Skin antibacterial cream and preparation method thereof Download PDFInfo
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- CN113143992A CN113143992A CN202110543023.7A CN202110543023A CN113143992A CN 113143992 A CN113143992 A CN 113143992A CN 202110543023 A CN202110543023 A CN 202110543023A CN 113143992 A CN113143992 A CN 113143992A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Abstract
The invention discloses a skin bacteriostatic cream and a preparation method thereof, wherein the skin bacteriostatic cream comprises the following raw materials in parts by weight: 3.0-9.5 parts of moxa leaf oil, 2.0-10.0 parts of peppermint oil, 2.0-10.0 parts of medical alcohol or medical alcohol water solution, 1.0-2.5 parts of carbomer resin, 1.5-4.5 parts of triethanolamine and 1.5-4.5 parts of non-ionic emulsifier. The invention also provides a preparation method of the skin antibacterial cream. The blumea oil, the peppermint oil and the medical alcohol have the effects of sterilization and disinfection, and can effectively kill bacteria on the surface of skin. Meanwhile, the blumea oil can warm the channels and dredge the collaterals, the peppermint oil can expand pores and blood vessels, and the blumea oil and the peppermint oil have the effect of helping the effective sterilization components to permeate into the skin, so that the drug effect of the invention is enhanced, and the durability of the drug effect is ensured.
Description
Technical Field
The invention relates to a skin bacteriostatic cream, in particular to a skin bacteriostatic cream and a preparation method thereof, belonging to the technical field of medicine preparation.
Background
Skin infections and skin lesions can cause skin disorders, with skin disorders caused by skin infections being more common. Skin infections are mainly caused by bacteria or fungi, such as staphylococcus aureus, escherichia coli, candida albicans, and the like. Therefore, clinical treatments of skin diseases caused by skin infections generally employ disinfection and bacteriostasis treatment methods. The existing skin disinfection and sterilization medicines mainly adopt antibacterial components, such as chlorhexidine and other western patent medicines. However, these western bacteriostatic agents have an irritant effect and are not suitable for sensitive skin. In order to solve the problems, the technical personnel of the field adopt the traditional Chinese medicine sterilization components to replace western medicine components, such as wild chrysanthemum, barberry root, Chinese honeylocust fruit and the like, so as to reduce the irritation of the bacteriostatic agent. Although these herbal ingredients have low irritation to skin sterilizing agents, the duration of the drug action is low.
Disclosure of Invention
The invention aims to solve the problems and provide a skin bacteriostatic cream and a preparation method thereof.
The invention realizes the purpose through the following technical scheme: a skin antibacterial cream and its preparation method are provided, which comprises oleum folium Artemisiae Argyi, oleum Menthae Dementholatum, alcohol, carbomer resin, triethanolamine and emulsifier; according to the weight portion, the blumea oil is 3.0-9.5 portions, the peppermint oil is 2.0-10.0 portions, the alcohol is 2.0-10.0 portions, the carbomer resin is 1.0-2.5 portions, the triethanolamine is 1.5-4.5 portions, and the emulsifier is 1.5-4.5 portions.
As a still further scheme of the invention: the alcohol may be medical alcohol or medical alcohol water solution.
As a still further scheme of the invention: the medical alcohol water solution used by the alcohol is 50% (V/V) medical alcohol water solution.
As a still further scheme of the invention: the carbomer resin is carbomer resin 940.
As a still further scheme of the invention: the emulsifier is a nonionic emulsifier, and the emulsifier is span 80.
As a still further scheme of the invention: the skin antibacterial cream also contains 50-100 parts of polyvinylpyrrolidone.
As a still further scheme of the invention: the skin antibacterial cream also contains 0.03-0.17 part of preservative; the preservative is preferably paraben.
As a still further scheme of the invention: the skin antibacterial cream also contains 0.01-0.07 part of edible pigment.
A skin antibacterial cream is prepared by the following steps:
s1, mixing carbomer resin with purified water to fully dissolve the carbomer resin;
s2, mixing oleum folium Artemisiae Argyi, oleum Menthae Dementholatum, medical alcohol or medical alcohol water solution, and nonionic emulsifier uniformly;
s3, uniformly mixing the mixture of S1 and the mixture of S2;
s4, adding triethanolamine into the mixture of S3, stirring uniformly, standing and solidifying to obtain the skin antibacterial cream.
As a still further scheme of the invention: the preparation method further comprises adding one or more of polyvinylpyrrolidone, antiseptic, and food color in step S2 or S3.
The invention has the beneficial effects that: the skin antibacterial cream and its preparation method are reasonable in design, and adopts oleum folium Artemisiae Argyi and oleum Menthae Dementholatum as main ingredients. The oleum folium Artemisiae Argyi has antibacterial, antiviral, and hemostatic effects, and also has effects of warming and activating meridian, promoting qi circulation, and promoting blood circulation when used externally. The oleum Menthae Dementholatum has antibacterial and antibacterial effects, and can stimulate skin to cause pore expansion and deep blood vessel change, and help other effective components penetrate into skin, and the oleum folium Artemisiae Argyi, oleum Menthae Dementholatum and medical alcohol have antibacterial and disinfectant effects, and can effectively kill bacteria on skin surface. Meanwhile, the blumea oil can warm the channels and dredge the collaterals, the peppermint oil can expand pores and blood vessels, and the blumea oil and the peppermint oil have the effect of helping the effective sterilization components to permeate into the skin, so that the drug effect of the invention is enhanced, and the durability of the drug effect is ensured. The polyvinyl pyrrolidone and the triethanolamine improve the moisturizing effect of the invention and have the function of relieving itching.
Drawings
FIG. 1 is a schematic diagram showing the formulation ratio of the present invention.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example one
Referring to fig. 1, a skin antibacterial cream and a preparation method thereof, including moxa leaf oil, peppermint oil, alcohol, carbomer resin, triethanolamine and an emulsifier; according to the weight portion, the blumea oil is 3.0-9.5 portions, the peppermint oil is 2.0-10.0 portions, the alcohol is 2.0-10.0 portions, the carbomer resin is 1.0-2.5 portions, the triethanolamine is 1.5-4.5 portions, and the emulsifier is 1.5-4.5 portions.
Further, in the embodiment of the present invention, the alcohol may be medical alcohol or a medical alcohol aqueous solution.
Furthermore, in the embodiment of the present invention, the medical alcohol aqueous solution used in the alcohol is 50% (V/V) medical alcohol aqueous solution, and generally, the alcohol concentration needs to reach 75% (V/V) to have a bactericidal effect, but the inventor finds, through a large number of experiments, that the alcohol with a low concentration is used as an auxiliary bactericide under the premise of matching with the two components of the argyi leaf oil and the peppermint oil, so that the effective bactericidal and bacteriostatic effects can be achieved, and a strong stimulation feeling can not be caused to a patient due to the large amount of the alcohol. Meanwhile, alcohol can promote local blood circulation and is helpful for effective components to penetrate into skin.
Further, in the present embodiment, the carbomer resin is carbomer resin 940, which is a cross-linked polyacrylic acid, widely used in the art as a dispersion stabilizer and a viscosity increasing thickener; according to the invention, carbomer resin and triethanolamine are used in a matching manner, and the cross-linking effect of the latter on the carbomer resin is utilized, so that an effective thickening and stabilizing effect can be realized under the condition of small using amount of the carbomer resin, and the relative content of effective components in the antibacterial cream is improved. Meanwhile, the product has certain moisturizing effect and can achieve the effects of moistening and relieving itching.
Further, in the embodiment of the invention, the emulsifier is a nonionic emulsifier, and the emulsifier is span 80, so that mutual solubility of effective components of the oil phase and water phase components is further promoted, and stability of the antibacterial cream is improved. The nonionic emulsifier is not particularly limited and any emulsifier that can be used in the art for pharmaceuticals can be used.
Furthermore, in the embodiment of the invention, the skin antibacterial cream also contains 50-100 parts of polyvinylpyrrolidone, and the polyvinylpyrrolidone is used as an auxiliary thickener, so that the viscosity of the cream can be further improved, and the rheological property of the cream can be changed; meanwhile, the polyvinylpyrrolidone has no stimulation to skin and eyes, and can enhance the moistening and lubricating effects of the ointment.
In the embodiment of the invention, the skin bacteriostatic cream further comprises 0.03-0.17 part of preservative, and the selection of the antibacterial agent is not particularly limited, and any antibacterial agent which can be used in medical materials in the field can be used. Preferably, paraben is used.
Furthermore, in the embodiment of the invention, the skin bacteriostasis cream also contains 0.01-0.07 part of edible pigment.
A skin antibacterial cream is prepared by the following steps:
s1, mixing carbomer resin with purified water to fully dissolve the carbomer resin;
s2, mixing oleum folium Artemisiae Argyi, oleum Menthae Dementholatum, medical alcohol or medical alcohol water solution, and nonionic emulsifier uniformly;
s3, uniformly mixing the mixture of S1 and the mixture of S2;
s4, adding triethanolamine into the mixture of S3, stirring uniformly, standing and solidifying to obtain the skin antibacterial cream.
Further, in the embodiment of the present invention, the preparation method further includes a step of adding one or more of polyvinylpyrrolidone, preservative, and food color in the step of S2 or S3.
Example two
The formula and the preparation method of the skin antibacterial cream shown in the embodiment are as follows:
s1, mixing 2.5g of carbomer resin 940 with 50mL of purified water to fully dissolve the carbomer resin 940;
s2, mixing 5g of oleum folium Artemisiae Argyi, 5g of oleum Menthae Dementholatum, 15g of 15% (V/V) medical alcohol water solution, and 3g of span 80;
s3, uniformly mixing the mixture of S1 and the mixture of S2;
s4, adding 1.5g of triethanolamine into the mixture of S3, uniformly stirring, standing and solidifying to obtain the skin antibacterial cream. This example provides a typical skin bacteriostatic cream.
EXAMPLE III
The formula and the preparation method of the skin antibacterial cream shown in the embodiment are as follows:
s1, mixing 2.5g of carbomer resin 940 with 20mL of purified water to fully dissolve the carbomer resin 940;
s2, mixing 8g of blumea oil, 10g of peppermint oil, 5g of medical alcohol and 3g of span 80 uniformly;
s3, uniformly mixing the mixture of S1 and the mixture of S2;
s4, adding 1.5g of triethanolamine into the mixture of S3, uniformly stirring, standing and solidifying to obtain the skin antibacterial cream.
The embodiment provides a skin bacteriostatic cream which specifically enhances the bacteriostatic effect and has strong irritation.
Example four
In addition to example two, 50g of polyvinylpyrrolidone was added in step S2, and the procedure was otherwise the same as in example two.
This example provides a high viscosity skin bacteriostatic cream.
EXAMPLE five
The same procedure as in example two was repeated except that 50g of polyvinylpyrrolidone was added in step S3 and 0.15g of ethylparaben and 0.05g of tea green pigment were added in step S4.
The embodiment provides a skin bacteriostatic cream with a green appearance.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference sign in a claim should not be construed as limiting the claim concerned.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (10)
1. A skin antibacterial cream comprises oleum folium Artemisiae Argyi, oleum Menthae Dementholatum, alcohol, carbomer resin, triethanolamine and emulsifier; the method is characterized in that: according to the weight portion, the blumea oil is 3.0-9.5 portions, the peppermint oil is 2.0-10.0 portions, the alcohol is 2.0-10.0 portions, the carbomer resin is 1.0-2.5 portions, the triethanolamine is 1.5-4.5 portions, and the emulsifier is 1.5-4.5 portions.
2. A skin bacteriostatic cream according to claim 1, characterized in that: the alcohol may be medical alcohol or medical alcohol water solution.
3. A skin bacteriostatic cream according to claim 2, characterized in that: the medical alcohol water solution used by the alcohol is 50% (V/V) medical alcohol water solution.
4. A skin bacteriostatic cream according to claim 1, characterized in that: the carbomer resin is carbomer resin 940.
5. A skin bacteriostatic cream according to claim 1, characterized in that: the emulsifier is a nonionic emulsifier, and the emulsifier is span 80.
6. A skin bacteriostatic cream according to claims 1-5, characterized in that: the skin antibacterial cream also contains 50-100 parts of polyvinylpyrrolidone.
7. A skin bacteriostatic cream according to claims 1-5, characterized in that: the skin antibacterial cream also contains 0.03-0.17 part of preservative; the preservative is preferably paraben.
8. A skin bacteriostatic cream according to claims 1-5, characterized in that: the skin antibacterial cream also contains 0.01-0.07 part of edible pigment.
9. A skin antibacterial cream is prepared by the following steps:
s1, mixing carbomer resin with purified water to fully dissolve the carbomer resin;
s2, mixing oleum folium Artemisiae Argyi, oleum Menthae Dementholatum, medical alcohol or medical alcohol water solution, and nonionic emulsifier uniformly;
s3, uniformly mixing the mixture of S1 and the mixture of S2;
s4, adding triethanolamine into the mixture of S3, stirring uniformly, standing and solidifying to obtain the skin antibacterial cream.
10. The method of claim 9, further comprising the step of adding one or more of polyvinylpyrrolidone, preservative, food coloring in step S2 or S3.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110543023.7A CN113143992A (en) | 2021-05-19 | 2021-05-19 | Skin antibacterial cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110543023.7A CN113143992A (en) | 2021-05-19 | 2021-05-19 | Skin antibacterial cream and preparation method thereof |
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| Publication Number | Publication Date |
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| CN113143992A true CN113143992A (en) | 2021-07-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110543023.7A Withdrawn CN113143992A (en) | 2021-05-19 | 2021-05-19 | Skin antibacterial cream and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059300A (en) * | 2022-11-29 | 2023-05-05 | 伊犁弥玥泉生物科技有限公司 | Skin antibacterial paste and preparation process thereof |
-
2021
- 2021-05-19 CN CN202110543023.7A patent/CN113143992A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116059300A (en) * | 2022-11-29 | 2023-05-05 | 伊犁弥玥泉生物科技有限公司 | Skin antibacterial paste and preparation process thereof |
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| PB01 | Publication | ||
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| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20210723 |