CN104586899B - A kind of aerosol and preparation method thereof for treating bedsore - Google Patents
A kind of aerosol and preparation method thereof for treating bedsore Download PDFInfo
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- CN104586899B CN104586899B CN201510065985.0A CN201510065985A CN104586899B CN 104586899 B CN104586899 B CN 104586899B CN 201510065985 A CN201510065985 A CN 201510065985A CN 104586899 B CN104586899 B CN 104586899B
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- antibacterial peptide
- treating bedsore
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Abstract
The present invention relates to a kind of aerosols and preparation method thereof for treating bedsore, belong to medicinal aerosol technical field.The aerosol is grouped as by following group:Antibacterial peptide, water soluble chitosan, synergist, stabilizer, propellant, surplus are pure water.Preparation method is:Antibacterial peptide solution and chitosan solution are prepared respectively, equivalent synergist and stabilizer are successively all added into two kinds of solution, then two kinds of solution are uniformly mixed, liquid is made, and filling, propellant is injected in sealing, and aerosol lid is up to product in pressure.Aerosol of the present invention passes through antibacterial peptide and water soluble chitosan compatibility; generate synergistic function; not only antibacterial anti-inflammatory is strong; and accelerating wound healing, the chitosan solution of clinical treatment bedsore excellent, ejection forms a film in skin surface quickly; the effective protection surface of a wound; infection risk is reduced, and the film can be degraded and absorbed, it is safe and clean, convenient;Aerosol active constituent is stablized, and effect efficacy time is long, is not necessarily to frequent drug administration, and biddability is good.
Description
Technical field
The present invention relates to a kind of aerosols, and in particular to a kind of aerosol and preparation method thereof for treating bedsore belongs to doctor
With aerosol spray technique field.
Background technology
Bedsore, also known as pressure sore, pressure ulcer etc., be since local organization is pressurized for a long time, occur continuous ischemia, anoxic,
It is malnutritive and cause tissue fester downright bad, be clinically one of most common complication, be more common in the critical state of an illness, long-term bed,
The patients such as unconsciousness, gatism, quadriplegia, trophic disturbance, dysbolism mostly occur in no muscle package or flesh
Sarcocyte is relatively thin, lacks the bone knuckle that adipose tissue protection is often pressurized again at.Bedsore not only brings pain to patient, has an effect on original
The recovery for sending out disease, even results in and suffers from septicemia, amputation or death, there are about 60,000 people to die of every year according to related document report
Bedsore complication.
Chitosan is a kind of natural biological polysaccharide generated after chitin is deacetylated, is that the unique alkalinity of nature is more so far
Sugar, natural resources very abundant.Due to excellent biocompatibility, antibiotic property, film forming, promoting to be cured effect, and can give birth to
Object degradation is safe and non-toxic, and chitosan is widely used in the fields such as medicine, food, bioengineering, especially chitosan and its spreads out
The rush of biology more acts on oneself and is confirmed by numerous scholar research institutes, is applied in clinic.As artificial skin, chitosan can promote
Into wound epithelialization, granulation tissue, accelerating wound healing are formed.
Antibacterial peptide is also known as antimicrobial peptide, is that biologic artifact generates during resisting the defense reaction of pathogenic microorganism
One kind have antimicrobial acivity micromolecule polypeptide class natural biological preparation, as a kind of new natural bio-antimicrobial agents
It attracts attention extensively.Bafillus natto antibacterial peptide is the recombinant antimicrobial peptide of bafillus natto NT-6 bacterial strains production, withered by her
Lavendustin(iturin), fragrant shepherd's purse element(fengycin)And Surfactin(surfactin)Three classes antibacterial lipopeptid homologue mixes
Close object composition.Studies have shown that the antibacterial peptide has preferable stability, in long-time high temperature(100 DEG C, 30 min)And wide scope
Under acid-base condition(pH 2~12)Not loss of activity are resistant to the hydrolysis of papain, pepsin and trypsase;Antibacterial
Spectrum is wide, can inhibit a variety of Gram-positives, negative pathogenic or putrefactivebacteria, especially have extremely strong inhibiting effect to mould;Have
Good water phase and an oil phase solvability, while oral administration safety is high.These good characteristics show the antibacterial peptide as a kind of novel
Natural bio-antimicrobial agents have broad prospect of application.
Currently, the clinical treatment of bedsore is mainly physical therapy and drug therapy.Its drug treatment is with antibacterial anti-inflammatory
It is main, validity is lacked for musculature regeneration, wound healing, so clinical efficacy is unsatisfactory;Most of antibacterials are not
Only certain toxic side effect, and dosage form is paste or aqua, and inconvenient for use, easy to pollute, frequent medication, biddability is poor.And have
The research for closing bedsore aerosol is actually rare, Chinese invention " a kind of chitosan-based bedsore aerosol and preparation method thereof ", application
Numbers 201110201687.1 disclose a kind of chitosan-based bedsore aerosol and preparation method thereof, which is molten in spirit of vinegar
Tea tree ethereal oil and emulsifier are added in the chitosan solution of solution, indentation propellant obtains a kind of emulsion-type aerosol.But due to this
Antibacterial material tea tree ethereal oil is that effumability ingredient needs frequent drug administration, biddability so effect efficacy time is short in aerosol
Difference;In addition, pure chitosan promotes wound repair process slow, curative effect is not very notable.
Invention content
The object of the present invention is to provide a kind of aerosols and preparation method thereof for treating bedsore, overcome the prior art not
Foot, is dedicated to developing a kind for the treatment of bedsore aerosol safe and clean, convenient, biddability is good, curative effect is good, simple for process, easily
In large-scale production.
To achieve the above object, the technical solution adopted by the present invention is as follows:
A kind of aerosol for treating bedsore, is grouped as by following group:
Antibacterial peptide 0.1~2%, water soluble chitosan 0.2~1.5%, synergist 1~5%, stabilizer 0.5~3%, propellant
20~48%, surplus is pure water.
The antibacterial peptide is bafillus natto antibacterial peptide, is the composite antibacterial of bafillus natto NT-6 bacterial strains production
Peptide, by iturin(iturin), fragrant shepherd's purse element(fengycin)And Surfactin(surfactin)Three classes antibacterial lipopeptid is same
It is the mixture composition of object;
The water soluble chitosan is carboxymethyl chitosan or low molecular weight(3-50kDa)Chitosan;
The synergist is vitamin B2;
The stabilizer is sodium chloride or potassium chloride;
The propellant is dimethyl ether.
The present invention also provides a kind of preparation methods of aerosol that treating bedsore, include the following steps:
(1)Two parts of pure water of equivalent are taken, prepare antibacterial peptide solution and chitosan solution respectively;
(2)To step(1)Equivalent synergist and stabilizer, stirring and dissolving are successively all added in prepared two kinds of solution;
(3)By step(2)Prepared two kinds of solution be uniformly mixed and be made liquid, sterilization is filling, and sealing, injection is cast
Agent, up to product after aerosol lid in pressure.
The beneficial effects of the invention are as follows:
1. the recombinant antimicrobial peptide and water soluble chitosan compatibility that are produced by bafillus natto NT-6 bacterial strains, generate association
Same synergistic effect, antibiosis, the two Synergistic antimicrobial, not only has a broad antifungal spectrum, antibacterial anti-inflammatory ability are stronger;Promote to be cured aspect, antibacterial
Peptide enhances nutrition, in vitamin B2In the presence of cooperate with chitosan acceleration of tissue repair, wound healing, clinical treatment bedsore effect
Fruit is splendid;
2. the chitosan solution that aerosol of the present invention sprays forms a film in skin surface quickly, the can effectively protect surface of a wound, reduce
Infection risk, and the film can be degraded and absorbed, it is safe and clean, convenient;
3. aerosol active constituent of the present invention is stablized, effect efficacy time is long, is not necessarily to frequent drug administration, and biddability is good.
Specific implementation mode
The present invention is described in further details below by example, these examples are only used for illustrating the present invention, and unlimited
The scope of the present invention processed;
Embodiment 1
At room temperature, two part of 29 g pure water is taken(Total 58 g)1.5 g antibacterial peptides and 0.5 g carboxymethyl chitosans are dissolved respectively
Solution is made in sugar;1.0 g vitamin Bs are all successively added into two solution2(Total 2.0 g)With 1.5 g sodium chloride(Total 3.0
g), stirring and dissolving;Above two solution is uniformly mixed, liquid is made, sterilization is filling, sealing, 35 g dimethyl ether of injection, in pressure
Aerosol lid is up to product.
Embodiment 2
At room temperature, two part of 35 g pure water is taken(Total 70 g)1.8 g antibacterial peptides and 1.2 g carboxymethyl chitosans are dissolved respectively
Solution is made in sugar;2.5 g vitamin Bs are all successively added into two solution2(Total 5.0 g)With 1.0 g potassium chloride(Total 2.0
g), stirring and dissolving;Above two solution is uniformly mixed, liquid is made, sterilization is filling, sealing, 20 g dimethyl ether of injection, in pressure
Aerosol lid is up to product.
Embodiment 3
At room temperature, two part of 33 g pure water is taken(Total 66 g)0.5 g antibacterial peptides and 1.5 g low molecular weights are dissolved respectively(3
kDa)Solution is made in chitosan;2.0 g vitamin Bs are all successively added into two solution2(Total 4.0 g)With 1.0 g potassium chloride
(Total 2.0 g), stirring and dissolving;Above two solution is uniformly mixed, liquid is made, sterilization is filling, and 26 g bis- are injected in sealing
Methyl ether, aerosol lid is up to product in pressure.
Embodiment 4
At room temperature, two part of 24.5 g pure water is taken(Total 49 g)0.1 g antibacterial peptides and 0.2 g carboxymethyl shells are dissolved respectively
Solution is made in glycan;0.5 g vitamin Bs are all successively added into two solution2(Total 1.0 g)With 0.85 g sodium chloride(It is total
1.7 g), stirring and dissolving;Above two solution being uniformly mixed, liquid is made, sterilization is filling, and 48 g dimethyl ether are injected in sealing,
Aerosol lid is up to product in pressure.
Embodiment 5
At room temperature, two part of 34.5 g pure water is taken(Total 69 g)1.0 g antibacterial peptides and 0.8 g low molecular weights are dissolved respectively
(50 kDa)Solution is made in chitosan;1.5 g vitamin Bs are all successively added into two solution2(Total 3.0 g)With 0.6 g chlorine
Change potassium(Total 1.2 g), stirring and dissolving;Above two solution is uniformly mixed, liquid is made, sterilization is filling, sealing, injection 25
G dimethyl ether, aerosol lid is up to product in pressure.
Embodiment 6
At room temperature, two part of 31 g pure water is taken(Total 62 g)2.0 g antibacterial peptides and 0.5 g low molecular weights are dissolved respectively
(10 kDa)Solution is made in chitosan;2.0 g vitamin Bs are all successively added into two solution2(Total 4.0 g)With 0.25 g
Sodium chloride(Total 0.5 g), stirring and dissolving;Above two solution is uniformly mixed, liquid is made, sterilization is filling, seals, injection
31 g dimethyl ether, aerosol lid is up to product in pressure.
Claims (7)
1. a kind of aerosol for treating bedsore, it is characterised in that:It is grouped as by following group:
Antibacterial peptide 0.1~2%, water soluble chitosan 0.2~1.5%, synergist 1~5%, stabilizer 0.5~3%, propellant 20~
48%, surplus is pure water.
2. a kind of aerosol for treating bedsore according to claim 1, it is characterised in that:The antibacterial peptide is natto gemma bar
Bacterium antibacterial peptide is the recombinant antimicrobial peptide of bafillus natto NT-6 bacterial strains production, by iturin iturin, fragrant shepherd's purse element
The mixture of fengycin and Surfactin surfactin three classes antibacterial lipopeptid homologues forms.
3. a kind of aerosol for treating bedsore according to claim 1, it is characterised in that:The water soluble chitosan is carboxylic first
Base enclosure glycan.
4. a kind of aerosol for treating bedsore according to claim 1, it is characterised in that:The synergist is vitamin B2。
5. a kind of aerosol for treating bedsore according to claim 1, it is characterised in that:The stabilizer is sodium chloride or chlorine
Change potassium.
6. a kind of aerosol for treating bedsore according to claim 1, it is characterised in that:The propellant is dimethyl ether.
7. a kind of preparation method of aerosol that treating bedsore according to claim 1, it is characterised in that:Including walking as follows
Suddenly:
(1)Two parts of pure water of equivalent are taken, prepare antibacterial peptide solution and chitosan solution respectively;
(2)To step(1)Equivalent synergist and stabilizer, stirring and dissolving are successively all added in prepared two kinds of solution;
(3)By step(2)Prepared two kinds of solution be uniformly mixed and be made liquid, sterilization is filling, and propellant is injected in sealing,
Up to product after aerosol lid in pressure.
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CN106860401A (en) * | 2017-02-09 | 2017-06-20 | 林映津 | A kind of pure natural wound restoration agent |
CN107184953A (en) * | 2017-05-22 | 2017-09-22 | 山东省科学院生物研究所 | A kind of antibacterial lipopeptid sebum film remediation composition and its application |
CN113101405A (en) * | 2020-03-23 | 2021-07-13 | 杭州鹿扬科技有限公司 | Method for preparing protective wound dressing |
CN112891615B (en) * | 2021-01-14 | 2022-06-10 | 广州贝奥吉因生物科技股份有限公司 | Liquid adhesive bandage and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101720237A (en) * | 2007-06-25 | 2010-06-02 | 利波佩普蒂德有限公司 | New medical products |
CN102293828A (en) * | 2011-07-14 | 2011-12-28 | 广东海洋大学 | Chitosan-based bedsore aerosol preparation and its preparation method |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN101720237A (en) * | 2007-06-25 | 2010-06-02 | 利波佩普蒂德有限公司 | New medical products |
CN102293828A (en) * | 2011-07-14 | 2011-12-28 | 广东海洋大学 | Chitosan-based bedsore aerosol preparation and its preparation method |
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