CN113520896A - Composition with acne removing and acne mark repairing functions and preparation method thereof - Google Patents
Composition with acne removing and acne mark repairing functions and preparation method thereof Download PDFInfo
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- CN113520896A CN113520896A CN202110884037.5A CN202110884037A CN113520896A CN 113520896 A CN113520896 A CN 113520896A CN 202110884037 A CN202110884037 A CN 202110884037A CN 113520896 A CN113520896 A CN 113520896A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention provides a composition with acne removing and acne mark repairing functions, which comprises the following components: oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8, aloe extract, mung bean extract, glycerol, butylene glycol and deionized water. The composition of the invention takes bioactive polypeptide as a main material, combines the mild skin care activity of natural plant extracts, has better effects of sterilizing, removing acnes and repairing acne marks, and can improve skin quality and improve skin vitality.
Description
Technical Field
The invention belongs to the technical field of skin care products, and particularly relates to a composition with acne removing and acne mark repairing functions and a preparation method thereof.
Background
Acne, commonly known as whelk, occurs more commonly among various people, especially young people, and statistically about 85% of people in adolescence suffer from acne of different degrees. The generation of acne and its remaining scars seriously affect the appearance of the patient. The beauty product is used as the most common and safe means for preventing and treating acne, and in the products with various layers, such as aloe, chamomile, sea buckthorn fruit, rose, azalea and other natural plant components and traditional Chinese medicine components, skin grease can be safely regulated, and the skin can be sterilized and fundamentally removed, but the acne is fundamentally removed by using the natural plant components, the acne removing period is long, marks after the acne is removed are not easy to remove, the components are complex, and the acne removing effect of anti-androgens, antibiotics, salicylic acid, prednisone, dexamethasone and other western medicines is quick, but the side effect is strong, the generation of drug-resistant bacteria is easy to cause by using a large amount of the cosmetics, and the cosmetics have irritation to the skin, so the cosmetics have the advantages of quick acne removing effect, capability of repairing the acne marks, easiness in component absorption and small side effect, and the bioactive polypeptides are gradually favored by acne patients.
At present, a plurality of acne removing products with the composition exist in the market, but the products cannot simultaneously have multiple effects of removing acnes, repairing acne marks and improving skin, or the bactericidal activity is ensured only by using too high amount of the products, the product components are too complex, a few components are irritating to people, or the product has high raw material cost, is not easy to store, is not suitable for large-scale preparation and the like. Therefore, the composition skin care product which can remove acne and repair acne marks and is easy to prepare is needed.
Disclosure of Invention
Aiming at the problems, the invention aims to provide a composition with the functions of removing acnes and repairing acne marks and a preparation method thereof.
The technical scheme of the invention is as follows:
a composition for removing acne and repairing acne marks comprises the following components: oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8, aloe extract, mung bean extract, glycerol, butylene glycol and deionized water;
among the above components, oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3 and palmitoyl tripeptide-8 are bioactive peptides, which are core components of the composition of the invention and are also water soluble phases; the aloe extract and the mung bean extract are plant extracts and are oil-soluble phases;
among the above components, oligopeptide-10 can rapidly cause the death of propionibacterium acnes; palmitoyl hexapeptide-21 antimicrobial and preservative agents, which inhibit staphylococcus aureus and other bacteria; hexapeptide-9 can promote epidermis regeneration, repair basement membrane, repair dermis layer and eliminate acne mark; palmitoyl tripeptide-8 novel polypeptide for relieving neurogenic inflammation of sensitive skin, and has antiinflammatory, anti-irritation and soothing effects; palmitoyl pentapeptide-3 can promote collagen regeneration and increase skin activity; the aloe and mung bean plant extracts can reduce sebum and grease secretion, repair skin, relieve and resist allergy;
the active ingredients in the composition are clear and easy to obtain, and the polypeptide components are easy to be absorbed through skin and exert the effect easily; the composition disclosed by the invention has the effects of improving the composition by taking the bioactive peptide as the core and combining with the plant extract with the effects of mildly protecting skin and reducing sebum secretion, has the effects of removing acne and acne marks, and is small in side effect.
As a specific technical scheme, the composition comprises the following components in percentage by mass: 0.1-5% of oligopeptide-10, 0.1-1% of palmitoyl hexapeptide-21, 1-3% of hexapeptide-9, 0.05-2.5% of palmitoyl pentapeptide-3, 0.05-2.5% of palmitoyl tripeptide-8, 1-5% of aloe extract, 1-5% of mung bean extract, 1-10% of glycerol, 5-10% of butanediol and the balance of deionized water.
A preparation method of a composition for removing acnes and repairing acne marks comprises the following steps:
(1) weighing oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8 and deionized water according to a formula, adding into a preparation pot, heating and stirring uniformly, and recording the obtained mixture as phase A;
(2) weighing aloe extract, mung bean extract, glycerol and butanediol according to a formula, adding into a preparation pot, heating, and stirring uniformly to obtain a mixture B;
(3) filtering the phase A and the phase B, stirring and uniformly mixing in a preparation pot, then vacuumizing and stirring, and discharging.
As a preferred technical scheme, the heating temperature in the step (1) is 25-30 ℃, the stirring time is 20-40min, and the rotating speed is 15-35 HZ.
As a preferred technical scheme, the heating temperature in the step (2) is 80-100 ℃, the stirring time is 60-120min, and the rotating speed is 30-50HZ, so as to improve the release of the plant active ingredients.
As a preferable technical scheme, a 200-400-mesh filter screen is adopted for the two phases A and B in the step (3), and the vacuum degree of a configured pot is-0.08 to-0.01 MPa.
The invention also discloses the application of the composition in cosmetics for removing acnes and repairing acne marks; the composition disclosed by the invention not only has the effects of removing acnes and repairing acne marks, but also has the synergistic effect of improving skin vitality, is almost colorless and tasteless, is convenient to add, and can be widely applied to various acne-removing and acne mark-repairing cosmetics.
The invention has the advantages that
1. The composition of the invention takes the bioactive polypeptide as the core, has high efficiency, low immunogenicity, low toxicity, clear active ingredients and easy absorption by human skin, and can achieve the effects of removing acnes and repairing skin with low dosage. And the plant extracts with mild effects are selected to synergistically improve the skin care activity.
2. According to the invention, oligopeptide-10 is selected to rapidly cause the death of propionibacterium acnes, an acne removing effect is achieved in a short period, palmitoyl hexapeptide-21 is selected to inhibit staphylococcus aureus and other bacteria, the oligopeptide-10 is assisted to further eliminate infection caused by other bacteria, a strong acne removing effect is achieved, hexapeptide-9 is selected to promote epidermis regeneration, repair basement membrane and repair dermis, an acne mark removing effect is achieved, a strong repairing effect is achieved, palmitoyl tripeptide-8 is selected to relieve neurogenic inflammation of sensitive skin, an anti-inflammatory, anti-irritation and soothing effect is achieved, palmitoyl pentapeptide-3 is selected to promote collagen regeneration, skin repairing activity is further increased, and aloe and mung bean plant extracts are selected to synergistically reduce sebum and grease secretion, repair skin, relieve and resist allergy. The composition is effective in improving acne and repairing skin lesion by combining different effects.
3. The composition has the effects of resisting inflammation, resisting stimulation and relieving the skin, and can be used for a long time.
4. The composition disclosed by the invention is simple in preparation method, easy in obtaining of active ingredients, wide in source, capable of being produced in a large scale, low in irritation to human skin, almost colorless and tasteless, and convenient to add, has multiple effects of removing acnes, repairing acne marks and improving skin, and can be widely applied to various cosmetics.
Detailed Description
The present invention will be further described with reference to the following detailed description, which should be construed as illustrative only, and not limiting the scope of the invention, which is to be given the full breadth of the appended claims, and all changes that can be made by those skilled in the art and which are, therefore, intended to be embraced therein.
Example 1
The composition with the functions of removing acnes and repairing acne marks comprises the following components in percentage by mass:
the preparation method comprises the following steps:
(1) weighing oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8 and deionized water according to a formula, adding into a preparation pot, heating at 30 deg.C and 25Hz, stirring for 30min until uniform, and recording the obtained mixture as phase A.
(2) Weighing Aloe extract, semen Phaseoli Radiati extract, glycerol and butanediol, adding into a pot, heating at 90 deg.C and 45Hz, stirring for 120min until uniform, and recording the obtained mixture as phase B.
(3) Filtering phase A and phase B with 200 mesh sieve, stirring at room temperature for 20min, mixing, vacuumizing to-0.03 MPa, stirring, and discharging.
Example 2
The composition with the functions of removing acnes and repairing acne marks comprises the following components in percentage by mass:
| components | Percentage content |
| Oligopeptide-10 | 0.5％ |
| Palmitoyl hexapeptide-21 | 0.25％ |
| Hexapeptide-9 | 1％ |
| Palmitoyl pentapeptide-3 | 0.2％ |
| Palmitoyl tripeptide-8 | 0.5％ |
| Aloe extract | 2.5％ |
| Mung bean extract | 2.5％ |
| Glycerol | 5％ |
| Butanediol | 10％ |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) weighing oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8 and deionized water according to a formula, adding into a preparation pot, heating at 30 deg.C and 25Hz, stirring for 30min until uniform, and recording the obtained mixture as phase A.
(2) Weighing Aloe extract, semen Phaseoli Radiati extract, glycerol and butanediol, adding into a pot, heating at 90 deg.C and 45Hz, stirring for 120min until uniform, and recording the obtained mixture as phase B.
(3) Filtering phase A and phase B with 200 mesh sieve, stirring at room temperature for 20min, mixing, vacuumizing to-0.03 MPa, stirring, and discharging.
Example 3
The composition with the functions of removing acnes and repairing acne marks comprises the following components in percentage by mass:
| components | Percentage content |
| Oligopeptide-10 | 2.5％ |
| Palmitoyl hexapeptide-21 | 1％ |
| Hexapeptide-9 | 3％ |
| Palmitoyl pentapeptide-3 | 0.2％ |
| Palmitoyl tripeptide-8 | 0.5％ |
| Aloe extract | 2.5％ |
| Mung bean extract | 2.5％ |
| Glycerol | 5％ |
| Butanediol | 10％ |
| Deionized water | Balance of |
The preparation method comprises the following steps:
(1) weighing oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8 and deionized water according to a formula, adding into a preparation pot, heating at 30 deg.C and 25Hz, stirring for 30min until uniform, and recording the obtained mixture as phase A.
(2) Weighing Aloe extract, semen Phaseoli Radiati extract, glycerol and butanediol, adding into a pot, heating at 90 deg.C and 45Hz, stirring for 120min until uniform, and recording the obtained mixture as phase B.
(3) Filtering phase A and phase B with 200 mesh sieve, stirring at room temperature for 20min, mixing, vacuumizing to-0.03 MPa, stirring, and discharging.
Example 4
Bacteriostatic test of the compositions of the invention.
First, experiment method
For the efficacy evaluation of the acne-removing cosmetics and the method thereof, China has relevant national standards and regulations. The trace-removing efficacy of cosmetics is generally evaluated by annex C4 of national standard of the people's republic of China, "hygienic Standard for Disposable sanitary articles (GB 15797-2002)" test method for bacteriostatic performance of dissolution-type antibacterial (bacteriostatic) products ".
Test strains: propionibacterium acnes ATCC6919, Escherichia coli ATCC25922 and Staphylococcus aureus ATCC 6538.
The culture conditions are as follows: culturing Escherichia coli and Staphylococcus aureus with common nutrient agar medium at 37 deg.C for 48 hr; the propionibacterium acnes is anaerobically cultured in a glucose nutrient solution at 37 ℃ for 48 hours.
Second, experimental results
The polypeptide acne-removing compositions prepared in example 1, example 2 and example 3 are diluted with 0.9% sterile physiological saline into 2% by mass, 4% by mass and 6% by mass of polypeptide acne-removing composition solutions with different concentrations, and are used for examining the bacteriostasis rate (%) of the composition of the invention for the experimental strains, and the results are shown in table 1.
TABLE 1 bacteriostatic effect of the composition of the invention on Propionibacterium acnes and Staphylococcus aureus of Escherichia coli
As can be seen from the table 1, the bacteriostatic conditions of the compositions of the invention in the examples 1, 2 and 3 with different contents all meet the standard, and the compositions can be judged to be capable of effectively preventing and inhibiting whelk; and the change of the concentration of the bactericidal component of the bioactive peptide in the composition obviously influences the bacteriostasis rate.
Example 5
The composition gel for removing acnes and repairing acnes marks comprises the following raw materials in percentage by weight: example 1 acne treatment composition 6%, glycerin 5%, acrylic acid/C10-30 alkanol acrylate crosspolymer 1.5%, sorbic acid 3%, betaine 1.5%, p-hydroxyacetophenone 0.2%, tromethamine 0.5%, caprylyl hydroxamic acid 0.1%, disodium EDTA 0.01%, sodium hyaluronate 0.05%, balance water.
Example 6
And (5) applying an acne removing effect experiment.
Experimental groups: taking the composition gel with the functions of removing acnes and repairing acne marks of example 5,
comparison group: example 5 was taken without the composition of example 1.
Trial objects: the people who grow pox on the face of 15-35 years old have pox marks and claim to easily grow pox. Each group had 20 people who applied topically, applied the gel to the acne or acne marks, gently massaged until absorption, 2 times per day for 2 weeks on trial, with the results shown in Table 2.
Table 2 smearing acne-removing effect of the polypeptide acne-removing composition of the present invention
As can be seen from table 2, the gel prepared by selecting 6% of the composition of example 1 can almost achieve the expected effect in the trial subjects, and has good effects of removing acne and acne marks, and simultaneously can improve the skin vitality. Meanwhile, no allergy phenomenon occurs in all the subjects, and the conditions of skin itch, stabbing pain, red swelling and the like do not occur.
Claims (7)
1. The composition with the functions of removing acnes and repairing acne marks is characterized by comprising the following components: oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8, aloe extract, mung bean extract, glycerol, butylene glycol and deionized water.
2. The composition with the functions of removing acnes and repairing acne marks as claimed in claim 1, which is characterized by comprising the following components in percentage by mass: 0.1-5% of oligopeptide-10, 0.1-1% of palmitoyl hexapeptide-21, 1-3% of hexapeptide-9, 0.05-2.5% of palmitoyl pentapeptide-3, 0.05-2.5% of palmitoyl tripeptide-8, 1-5% of aloe extract, 1-5% of mung bean extract, 1-10% of glycerol, 5-10% of butanediol and the balance of deionized water.
3. A preparation method of a composition for removing acnes and repairing acne marks is characterized by comprising the following steps:
(1) weighing oligopeptide-10, palmitoyl hexapeptide-21, hexapeptide-9, palmitoyl pentapeptide-3, palmitoyl tripeptide-8 and deionized water according to a formula, adding into a preparation pot, heating and stirring uniformly, and recording the obtained mixture as phase A;
(2) weighing aloe extract, mung bean extract, glycerol and butanediol according to a formula, adding into a preparation pot, heating, and stirring uniformly to obtain a mixture B;
(3) filtering the phase A and the phase B, stirring and uniformly mixing in a preparation pot, then vacuumizing and stirring, and discharging.
4. The preparation method of the composition for removing acne and repairing acne marks according to claim 3, wherein the heating temperature in the step (1) is 25-30 ℃, the stirring time is 20-40min, and the rotating speed is 15-35 HZ.
5. The preparation method of the composition for removing acne and repairing acne marks according to claim 3, wherein the heating temperature in the step (2) is 80-100 ℃, the stirring time is 60-120min, and the rotating speed is 30-50 HZ.
6. The preparation method of the composition for removing acne and repairing acne marks as claimed in claim 3, wherein in the step (3), the two phases A and B adopt 200-400 mesh filter screens, and the vacuum degree of the pot is-0.08-0.01 MPa.
7. Use of the composition according to claim 1 in cosmetics for removing acne and repairing acne marks.
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| CN202110884037.5A CN113520896A (en) | 2021-08-01 | 2021-08-01 | Composition with acne removing and acne mark repairing functions and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110884037.5A CN113520896A (en) | 2021-08-01 | 2021-08-01 | Composition with acne removing and acne mark repairing functions and preparation method thereof |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115531237A (en) * | 2022-10-12 | 2022-12-30 | 优微（珠海）生物科技有限公司 | Acne-removing repairing composition, acne-removing repairing microneedle patch and preparation method and application of acne-removing repairing microneedle patch |
| CN115737520A (en) * | 2022-12-16 | 2023-03-07 | 唤新肌生物科技(深圳)有限公司 | Oil-control acne-removing face-cleaning composition |
| CZ309857B6 (en) * | 2022-03-31 | 2023-12-20 | Contipro A.S. | Hexapeptide, compositions comprising this hexapeptide, and topical use thereof |
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| WO2012077120A2 (en) * | 2010-12-09 | 2012-06-14 | Y&B Mother's Choice Ltd. | Natural formulations |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN110251415A (en) * | 2019-08-01 | 2019-09-20 | 深圳市健翔生物制药有限公司 | A kind of antiallergic reparation facial mask containing polypeptide |
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2021
- 2021-08-01 CN CN202110884037.5A patent/CN113520896A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012077120A2 (en) * | 2010-12-09 | 2012-06-14 | Y&B Mother's Choice Ltd. | Natural formulations |
| CN105147534A (en) * | 2015-08-28 | 2015-12-16 | 深圳市维琪医药研发有限公司 | Polypeptide composition for skin repairing |
| CN110251415A (en) * | 2019-08-01 | 2019-09-20 | 深圳市健翔生物制药有限公司 | A kind of antiallergic reparation facial mask containing polypeptide |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ309857B6 (en) * | 2022-03-31 | 2023-12-20 | Contipro A.S. | Hexapeptide, compositions comprising this hexapeptide, and topical use thereof |
| CN115531237A (en) * | 2022-10-12 | 2022-12-30 | 优微（珠海）生物科技有限公司 | Acne-removing repairing composition, acne-removing repairing microneedle patch and preparation method and application of acne-removing repairing microneedle patch |
| CN115531237B (en) * | 2022-10-12 | 2023-11-03 | 优微（珠海）生物科技有限公司 | Acne-removing repairing composition, acne-removing repairing microneedle patch, and preparation method and application thereof |
| CN115737520A (en) * | 2022-12-16 | 2023-03-07 | 唤新肌生物科技(深圳)有限公司 | Oil-control acne-removing face-cleaning composition |
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Application publication date: 20211022 |