CN107822992A - A kind of feminine care wet tissue for preventing and treating puerperal infection - Google Patents

A kind of feminine care wet tissue for preventing and treating puerperal infection Download PDF

Info

Publication number
CN107822992A
CN107822992A CN201711260671.1A CN201711260671A CN107822992A CN 107822992 A CN107822992 A CN 107822992A CN 201711260671 A CN201711260671 A CN 201711260671A CN 107822992 A CN107822992 A CN 107822992A
Authority
CN
China
Prior art keywords
wet tissue
feminine care
care wet
tissue according
essential oil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711260671.1A
Other languages
Chinese (zh)
Inventor
孟君
李伏君
滕晖
蒋加拉
伍实花
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhuzhou Qianjin Pharmaceutical Co Ltd
Original Assignee
Zhuzhou Qianjin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhuzhou Qianjin Pharmaceutical Co Ltd filed Critical Zhuzhou Qianjin Pharmaceutical Co Ltd
Priority to CN201711260671.1A priority Critical patent/CN107822992A/en
Publication of CN107822992A publication Critical patent/CN107822992A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/30—Boraginaceae (Borage family), e.g. comfrey, lungwort or forget-me-not
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/345—Alcohols containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/37—Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to a kind of feminine care wet tissue for preventing and treating puerperal infection, it is prepared by the method comprised the following steps：(1) Asian puccoon, honeysuckle, moutan bark and folium eucalypti are taken respectively, are dried, are mixed after crushing, obtain mixed material；(2) CO 2 fluid of the mixed material by the use of ethanol water as entrainer is subjected to supercritical extract, obtains extract；(3) extract is diluted with the solvent being made up of ethanol and glycerine, takes filtrate after filtering, puerperal infection decoction must be prevented and treated；(4) decoction is attached in base fabric, produced.Feminine care wet tissue provided by the invention has remarkable result to preventing and treating puerperal infection, and for product after long-time is placed, antimicrobial stability is good, has good market popularization value.

Description

A kind of feminine care wet tissue for preventing and treating puerperal infection
Technical field
The present invention relates to female article field, and in particular to a kind of its preparation side of feminine care wet tissue for preventing and treating puerperal infection Method.
Background technology
It is a special physiology phase that women, which is confined in childbirth in postpartum, and slightly carelessness will leave slight illness, and the lochia unnet phase is defended It is raw particularly important, it is necessary to various diseases caused by preventing and treating puerperal infection.Involution of uterus returns to non-pregnant state, this life after childbirth Reason change about needs to complete for 42 days, and this period is referred to as puerperium.From after giving birth to placenta, puerpera just enters puerperium.Production Cotton-padded mattress heat be due to postpartum pathogenic bacteria intrusion reproductive organs caused by disease, medically cry puerperal infection, be puerpera in puerperium The more serious disease of the ratio that is susceptible to suffer from.The main pathogenic fungi for causing puerperal infection is staphylococcus, streptococcus, Escherichia coli, pneumonia Diplococcus etc..And because puerperal infection has a strong impact on perinatal health, or even threat to life, it is therefore necessary to prevention work is performed,
Patent document CN102697857A discloses a kind of puerpera's towel liquid medicine for preventing and treating puerperal infection and preparation method thereof, institute Puerpera's towel liquid medicine is stated to be made up of the composition of following parts by weight：Asian puccoon percolate 10-30 parts, chlorogenic acid 30-60 parts, Paeonol 5-20 Part, eucalyptus oil 1-20 parts.The pharmaceutical composition of the present invention can prevent postpartum infection, mitigate postpartum local skin discomfort, and energy The healing of Episiomy Wounds and the discharge of lochia, effect is promoted to be better than prior art.However, with the patent similarly, existing female Most of sex hygiene articles for use are concerned only with prevention or therapeutic effect in itself, and the long-term stability concern for product is less, causes There is certain difficulty in actual market popularization practical.
The content of the invention
It is an object of the present invention to the defects of overcoming prior art, there is provided a kind of feminine care of preventing and treating puerperal infection is wet Towel.Due to containing liquid component in wet tissue, place easily and occur going bad so as to influence wet tissue in the case where being added without preservative Fungistatic effect, wet tissue provided by the invention to raw material extracting method by optimizing, so as to being not added with the feelings of preservative Ensure that products obtained therefrom has good stability under condition.
Specifically, the invention provides a kind of feminine care wet tissue for preventing and treating puerperal infection, by what is comprised the following steps Method is prepared：
(1) Asian puccoon, honeysuckle, moutan bark and folium eucalypti are taken respectively, are dried, are mixed after crushing, obtain mixed material；
(2) CO 2 fluid of the mixed material by the use of ethanol water as entrainer is subjected to supercritical extract, Obtain extract；
(3) extract is diluted with the solvent being made up of ethanol and glycerine, takes filtrate after filtering, puerperium sense must be prevented and treated Contaminate decoction；
(4) decoction is attached in base fabric, produced.
The present invention obtains extract using carbon dioxide supercritical extraction.By supercritical carbon dioxide and material to be separated Contact, make it that selectively polarity size, boiling point the height composition different with molecular size range be extracted successively.Due to The extracting object of the present invention is compound, therefore in extraction, the extraction of traditional Chinese medicine ingredients promotes other Chinese medicines due to the effect of dissolving each other The extraction of composition, and active ingredient is highly concentrated, impurity is few, and appearance color is preferable, has collaboration supplementary result.It is of the invention abundant The characteristic of each component in compound is considered, selects entrainer to carry out assisted extraction, so as to improve the selectivity of supercritical fluid, with Ensure that the target product of the present invention can be proposed farthest, while prevention effect is improved, the hair beyond the present invention Existing, the extract obtained by said extracted method has good stability after being prepared into wet tissue, has extremely strong market should With value.
The present invention is by largely putting into practice discovery, when the entrainer is the ethanol water of volumetric concentration 60~80%, Optimal extraction effect can be obtained, and gained wet tissue product has optimal stability.The preferably entrainer of the invention Dosage is the 5~20% of the mixed material quality.As the present invention preferred scheme, the carbon dioxide supercritical extraction Pressure is 20~40Mpa, and temperature is 30~50 DEG C.
The solvent that the present invention uses is mixed by ethanol and glycerine.The present invention by largely putting into practice discovery, using by Both solvent mixed is diluted to the extract, can make the excitant in extraction process while being extracted Impurity sedimentation that is strong and influenceing stable effective ingredients, is then removed by follow-up settling step, so as to further improve The stability of wet tissue product.As the preferred scheme of the present invention, the solvent is by ethanol and glycerine with volume ratio 1:4~6 is mixed Conjunction forms.
The degree of step (3) described dilution can realize that preventing and treating and avoids menstruation infection effect with what this area was appreciated that Overstimulation is advisable, and in order to balance using effect and skin irritation, the extract is preferably diluted to former extraction by the present invention Take 70~90 times that liquid accumulates.
In order to improve market acceptance, the present invention adds natural perfume material or artificial flavors before filtration；Preferably, the day Right one or more of the spices in elscholtiza, borneol, oriental wormwood, peppermint, yellow wormwood artemisia；The artificial flavors be selected from plants essential oil and/ Or chemical synthesis essence, the plants essential oil are selected from Chinese torreya essential oil, mother chrysanthemum flower essential oil, daphne odera essential oil, pinecone essential oil, argy wormwood One or more in oil, thyme essential oil, eucalyptus quintessence oil, tea tree ethereal oil and camphor tree essential oil.
The base fabric is selected from non-woven fabrics or wet-strength paper.Before adhering liquid medicine, the base fabric first carry out it is suitably sized, so After carry out sterilization treatment.
Attachment of the present invention refers to soak base fabric with the decoction or the decoction is sprayed in base fabric.The spraying Specially：After carrying out atomization process to the decoction, high-pressure injection is in base fabric.
As a preferred embodiment of the present invention, the raw material is preferably the combination of following parts by weight：1~5 part of Asian puccoon, 1~5 part of 15~25 parts of honeysuckle, 5~10 parts of moutan bark and folium eucalypti.
In actual applications, the wet tissue should be independent packaging, to ensure using health.
The feminine care wet tissue of preventing and treating puerperal infection provided by the invention can prevent postpartum infection, mitigate postpartum part skin Skin is uncomfortable, promotes the healing of Episiomy Wounds and the discharge of lochia；And stability is good, still there is good antibacterial effect after long-term placement Fruit, there is extensive market application value.
Embodiment
Following examples are used to illustrate the present invention, but are not limited to the scope of the present invention.
Embodiment 1
A kind of feminine care wet tissue for preventing and treating puerperal infection is present embodiments provided, is prepared by the following method：
(1) Asian puccoon 3kg, honeysuckle 20kg, moutan bark 8kg and folium eucalypti 3kg are taken respectively, are dried, are mixed after crushing, must be mixed Raw material；
(2) using the mixed material, by the use of the ethanol water of concentration 70% as entrainer, (dosage of entrainer is described The CO 2 fluid 10%) of mixed material quality, supercritical extract is carried out at being 40 DEG C in 30Mpa, temperature, must be extracted Liquid；
(3) with ethanol and glycerine with volume ratio 1:The extract is diluted to former extract by 5 solvents mixed 80 times of volume, take filtrate after filtering, produce preventing and treating puerperal infection decoction；
(4) high-pressure injection produces wet tissue by cutting, in the base fabric of sterilizing after the decoction being carried out into atomization process, Every wet tissue carries out independent packaging.
Embodiment 2
Compared with Example 1, differ only in, the step (1), (2) are specially：
(1) Asian puccoon 1kg, honeysuckle 15kg, moutan bark 5kg and folium eucalypti 1kg are taken respectively, are dried, are mixed after crushing, must be mixed Raw material；
(2) using the mixed material, by the use of the ethanol water of concentration 60% as entrainer, (dosage of entrainer is described The CO 2 fluid 5%) of mixed material quality, supercritical extract is carried out at being 30 DEG C in 20Mpa, temperature, obtains extract.
Embodiment 3
Compared with Example 1, differ only in, the step (1), (2) are specially：
(1) Asian puccoon 5kg, honeysuckle 25kg, moutan bark 10kg and folium eucalypti 5kg are taken respectively, are dried, are mixed after crushing, are obtained mixed Close raw material；
(2) using the mixed material, by the use of the ethanol water of concentration 80% as entrainer, (dosage of entrainer is described The CO 2 fluid 20%) of mixed material quality, supercritical extract is carried out at being 50 DEG C in 40Mpa, temperature, must be extracted Liquid.
Embodiment 4
Compared with Example 1, differ only in, the ethanol and glycerine that the step (3) uses are using volume ratio as 1:10.
Embodiment 5
Compared with Example 1, differ only in, the ethanol and glycerine that the step (3) uses are using volume ratio as 1:2.
Comparative example 1
Compared with Example 1, differ only in, the solvent of step (3) described dilution is 70% ethanol water.
Comparative example 2
Compared with Example 1, differ only in, the formula referenced patent document CN102697857A embodiments 2 of liquid medicine are public The formula opened, is specifically comprised：Asian puccoon percolate 25g, chlorogenic acid 40g, Paeonol 10g, eucalyptus oil 12g；
Preparation method is specially：
(1) chlorogenic acid, Paeonol, eucalyptus oil and Asian puccoon percolate are weighed by proportioning, it is standby；
(2) take 80g 95% ethanol to dissolve chlorogenic acid, after being well mixed, stand 20 minutes, filter, remove sediment, Obtain chlorogenic acid alcoholic solution；
(3) Asian puccoon percolate, eucalyptus oil and Paeonol are sequentially added in chlorogenic acid alcoholic solution, is well mixed, adds 95% Ethanol be settled to 200g, ultrasonic dissolution, to red, transparent solution, produce.
Passing through according to high-pressure injection after the decoction is carried out into atomization process with the step of embodiment 1 (4) identical mode Cut, in the base fabric of sterilizing, produce wet tissue, every wet tissue carries out independent packaging.
Experimental example 1：Effect experiment
Married woman totally 60 people of natural labor is selected, is randomly divided into 3 groups, every group of 20 people.Specially：1 group of embodiment (uses embodiment 1 provide wet tissue), 2 groups of comparative example (use with comparative example 2 provide wet tissue) and control group (use commercially available shikonin oil Agent).Postpartum infection result is counted after being used continuously 2 weeks.
Through statistics, the Maternal Infection rate of 2 groups of 1 group of embodiment and comparative example is 0, and control group Maternal Infection rate is 7.6%. Understand, wet tissue provided by the invention has good preventing and treating puerperal infection effect.
Experimental example 2：Long-time stability are tested
After the wet tissue that each embodiment and comparative example are provided is placed 0,2,6 month at normal temperatures respectively, bacteriostasis rate is tested, it is empty White control is undressed blank sterilizing non-woven fabrics.Experimental strain：Staphylococcus aureus, Candida albicans, Escherichia coli, Pseudomonas aeruginosa, hemolytic streptococcus；Specific experiment step refers to《15979-2002 disposable sanitary articles sanitary standards》Rule It is fixed.As a result as shown in table 1~3.
Table 1：0 month bacteriostasis rate (%)
Staphylococcus aureus Candida albicans Escherichia coli Pseudomonas aeruginosa Hemolytic streptococcus
Blank control 0 0 0 0 0
Embodiment 1 99.8 99.8 99.2 99.6 99.5
Embodiment 2 99.5 99.6 99.7 99.6 99.4
Embodiment 3 99.6 99.7 99.8 99.2 99.4
Embodiment 4 98.9 98.8 98.5 98.5 98.8
Embodiment 5 99.0 99.1 98.6 98.8 99.2
Comparative example 1 97.5 98.0 97.2 98.1 98.3
Comparative example 2 98.0 98.2 97.9 98.9 99.0
Table 2：2 months bacteriostasis rates (%)
Table 3：6 months bacteriostasis rates (%)
Staphylococcus aureus Candida albicans Escherichia coli Pseudomonas aeruginosa Hemolytic streptococcus
Blank control 0 0 0 0 0
Embodiment 1 97.8 98.2 97.1 98.2 97.6
Embodiment 2 97.6 97.6 98.3 97.8 97.1
Embodiment 3 98.1 96.9 98.4 97.7 96.9
Embodiment 4 97.2 97.1 96.9 95.4 97.2
Embodiment 5 96.5 95.4 95.6 96.9 98.0
Comparative example 1 90.6 88.5 84.6 85.1 83.6
Comparative example 2 84.6 82.6 85.9 87.4 81.9
From result above, wet tissue provided by the invention has good fungistatic effect, and is being not added with preservative In the case of through long-term biocidal property of placing keep stable.
Although above the present invention is made to retouch in detail with general explanation, embodiment and experiment State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art 's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed Scope.

Claims (10)

1. a kind of feminine care wet tissue for preventing and treating puerperal infection, it is characterised in that be prepared by the method comprised the following steps：
(1) Asian puccoon, honeysuckle, moutan bark and folium eucalypti are taken respectively, are dried, are mixed after crushing, obtain mixed material；
(2) CO 2 fluid of the mixed material by the use of ethanol water as entrainer is subjected to supercritical extract, must extracted Take liquid；
(3) extract is diluted with the solvent being made up of ethanol and glycerine, takes filtrate after filtering, puerperal infection medicine must be prevented and treated Liquid；
(4) decoction is attached in base fabric, produced.
2. feminine care wet tissue according to claim 1, it is characterised in that the entrainer is volumetric concentration 60~80% Ethanol water.
3. feminine care wet tissue according to claim 1 or 2, it is characterised in that the dosage of the entrainer is described mixed Close the 5~20% of material quality.
4. the feminine care wet tissue according to claims 1 to 3 any one, it is characterised in that the carbon dioxide is super to be faced The pressure of boundary's extraction is 20~40Mpa, and temperature is 30~50 DEG C.
5. feminine care wet tissue according to claim 1, it is characterised in that step (3) described solvent is by water and glycerine With volume ratio 1:4~6 mix.
6. feminine care wet tissue according to claim 1, it is characterised in that add natural perfume before step (3) described filtering Material or artificial flavors；
Preferably, one or more of the natural perfume material in elscholtiza, borneol, oriental wormwood, peppermint, yellow wormwood artemisia；The artificial fragrant Material is selected from plants essential oil and/or chemical synthesis essence, and the plants essential oil is selected from Chinese torreya essential oil, mother chrysanthemum flower essential oil, daphne odera essence One or more in oil, pinecone essential oil, mugwort oil, thyme essential oil, eucalyptus quintessence oil, tea tree ethereal oil and camphor tree essential oil.
7. feminine care wet tissue according to claim 1, it is characterised in that the base fabric is selected from non-woven fabrics or wet-strength paper.
8. feminine care wet tissue according to claim 7, it is characterised in that the attachment refers to soak base with the decoction The decoction is sprayed in base fabric by cloth.
9. feminine care wet tissue according to claim 8, it is characterised in that the spraying is specially：The decoction is carried out After atomization process, high-pressure injection is in base fabric.
10. the feminine care wet tissue according to claim 1~9 any one, it is characterised in that in step (1), take Asian puccoon 1~5 part, 15~25 parts of honeysuckle, 1~5 part of 5~10 parts of moutan bark and folium eucalypti.
CN201711260671.1A 2017-12-04 2017-12-04 A kind of feminine care wet tissue for preventing and treating puerperal infection Pending CN107822992A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711260671.1A CN107822992A (en) 2017-12-04 2017-12-04 A kind of feminine care wet tissue for preventing and treating puerperal infection

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201711260671.1A CN107822992A (en) 2017-12-04 2017-12-04 A kind of feminine care wet tissue for preventing and treating puerperal infection

Publications (1)

Publication Number Publication Date
CN107822992A true CN107822992A (en) 2018-03-23

Family

ID=61641458

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711260671.1A Pending CN107822992A (en) 2017-12-04 2017-12-04 A kind of feminine care wet tissue for preventing and treating puerperal infection

Country Status (1)

Country Link
CN (1) CN107822992A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753349A (en) * 2017-12-04 2018-03-06 株洲千金药业股份有限公司 A kind of feminine care wet tissue for preventing and treating menstruation infection
CN108272911A (en) * 2018-03-26 2018-07-13 广东力集团制药股份有限公司 A kind of preparation method of bruises and sprains spirit tincture

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727094A (en) * 2015-11-20 2017-05-31 青岛华南盛源果业有限公司 A kind of wet tissue for ladies only

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106727094A (en) * 2015-11-20 2017-05-31 青岛华南盛源果业有限公司 A kind of wet tissue for ladies only

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107753349A (en) * 2017-12-04 2018-03-06 株洲千金药业股份有限公司 A kind of feminine care wet tissue for preventing and treating menstruation infection
CN107753349B (en) * 2017-12-04 2021-01-26 株洲千金药业股份有限公司 Female nursing wet tissue for preventing and treating menstrual infection
CN108272911A (en) * 2018-03-26 2018-07-13 广东力集团制药股份有限公司 A kind of preparation method of bruises and sprains spirit tincture

Similar Documents

Publication Publication Date Title
CN106334067B (en) Gynecological gel containing silver ion antibacterial agent, preparation method and application
CN104224923A (en) Tea tree essential oil antimicrobial gel for treating vaginal disease in gynecology
CN104382786A (en) Hair loss prevention hair-blacking agent and preparation method thereof
KR101983990B1 (en) Cleansing composition comprising natural raw material extract and wet tissue comprising the same
CN107519100A (en) A kind of composition and its preparation method and application
CN108294060A (en) Plant-based bacteriostat and preparation method thereof
KR20160015718A (en) Feminine cleanser composition comprising Portulaca oleracea extract and Phytoncide
CN106726998A (en) A kind of acne-removing liquid containing Tea Flower extract solution
KR102133101B1 (en) A Feminine cleanser composition comprising imperata cylindrica leaf and artemisia princeps
CN107822992A (en) A kind of feminine care wet tissue for preventing and treating puerperal infection
CN107753999A (en) A kind of feminine hygiene articles for preventing and treating puerperal infection and preparation method thereof
KR101104898B1 (en) Skin detergent composition for anti-bacterial by using oriental herb extract
CN106727026B (en) Traditional Chinese medicine acne-removing composition and application thereof
CN104984196A (en) Antibacterial composition containing cortex dictamni and preparation method thereof
CN105012581A (en) Fresh aloe antibacterial composite, application and preparing method of fresh aloe antibacterial composite
CN107753349B (en) Female nursing wet tissue for preventing and treating menstrual infection
CN108451799A (en) A kind of hand cleanser and preparation method thereof
KR101915389B1 (en) Liquid cream type oriental soap and its making method
CN106265393A (en) A kind of blackhead captures facial film
CN107822991A (en) A kind of feminine care wet tissue of bacteriostatic and disease prevention
KR100807842B1 (en) Anti-fungal composition for deodorization
CN103736139B (en) A kind of natural antibiotic antiseptic and processing technology thereof and hygienic article
CN116236555A (en) Mask fragrance spray containing Chinese herbal medicine active ingredients and preparation method thereof
CN104288043B (en) Method for preparing natural plant antibacterial hand-washing solution
CN106421511A (en) Aloe antibacterial composition and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180323