CN107519100A - A kind of composition and its preparation method and application - Google Patents
A kind of composition and its preparation method and application Download PDFInfo
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- CN107519100A CN107519100A CN201710919255.1A CN201710919255A CN107519100A CN 107519100 A CN107519100 A CN 107519100A CN 201710919255 A CN201710919255 A CN 201710919255A CN 107519100 A CN107519100 A CN 107519100A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4993—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
- A61K2800/72—Hypo-allergenic
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Abstract
The invention provides a kind of composition and its preparation method and application, the composition is mainly prepared by the following raw material by mass percentage：Chinese medical extract 86 99%, plants essential oil 0.01 2% and tween 0.9 12%.The composite formula of the present invention is reasonable, Chinese medical extract and plants essential oil Synergistic, with removing acne, repair pockmark, suppress the effect of acne recurrence, the anti-acne skin care item of preparation are from suppressing bacterium, clearing heat and detoxicating, blood stasis-eliminating and stagnation-dissipating, penetrate deep into etc. comprehensive prevention and treatment acne.
Description
Technical field
The invention belongs to daily cosmetics field, is related to a kind of composition and its preparation method and application, and in particular to one
The composition of kind with acne-removing and its preparation method and application.
Background technology
Acne, also known as whelk, are apt to occur in teenager, are a kind of pilosebaceous follicle chronic inflammations, are mainly shown as and are suffering from
The face and chest and back of person forms acne, papule, warts, tubercle and tumour, and is accompanied by the symptoms such as red, swollen, pain, when more serious
Meeting inflammation infection, or even scar are very big to teen-age psychology and social influence.Trigger acne an important factor for one of be
The microorganisms such as propionibacterium acnes produce dissolved lipase in hyperplasia reproductive process, decompose sebum and produce free acid, cause follicular wall
Lesion ruptures so that the sebum of alluvial enters surrounding dermal tissue, causes inflamed papules even tumour.
At present, treatment acne mainly use steroids and antibiotics, and such medicine is inflamed for removal
Acne has the effect got instant result, but can not fundamentally cure acne, and long-term use can bring serious toxic side effect
And aggravate skin injury.For medicine of the skin care item with acne-removing compared with treatment acne, Small side effects, be it is a kind of it is daily must
Standby nursing materials, but most product for resolving poxes effect is not very obvious on the market.
The A of CN 105902425 disclose a kind of betaplex gentle cleansing milk for ladies only, and the mildy wash includes plants essential oil and Chinese medicine
Anti-acne composition, wherein Rosa Damascana or tea tree ethereal oil do not stimulate gently, and the Chinese medicine composition of cape jasmine, honeysuckle and witch hazel can be with
Facial bacterium is effectively strangled, but the mildy wash mainly has the effect of gentle cleaning, it is not tight after washing, to acne without aobvious
The therapeutic effect of work.
The A of CN 106833973 disclose a kind of cold process soap for acne of dispelling and preparation method thereof, and the cold process soap is by Camellia Sinensis Extract
Groomwell root oil, camellia oil, Sweet Almond Oil, grape-kernel oil, rice bran oil, coconut oil, sodium hydroxide, pure water, ruyi jinhuang powder, ruyi jinhuang san, Chinese medicine
Extract and plants essential oil are prepared by a certain percentage, have the function that cleaning skin, oil-control, acne of dispelling, but do not have
Nourishes effect.
Therefore, Chinese medical extract and plants essential oil are combined, there is provided a kind of composition with acne-removing, daily
Cosmetic field has great importance and wide market prospects.
The content of the invention
For overcome the deficiencies in the prior art, a kind of composition of offer of the invention and its preparation method and application, described group
Compound not only can effectively remove acne, suppress the growth of bacterium using natural Chinese medicinal herb and plants essential oil as primary raw material, and
The effect of with pockmark, nourishing skin is repaired.
To use following technical scheme up to this purpose, the present invention：
In a first aspect, the present invention provides a kind of composition, the composition is by mass percentage mainly by the following raw material system
It is standby to obtain：
Chinese medical extract 86-99%
Plants essential oil 0.01-2%
Tween 0.9-12%.
The nature and flavor and effect of each plant component of the present invention are as follows：
The red sage root：Containing tanshinone IIA and tanshin polyphenolic acid B, there is the effect of promoting blood circulation, nourishing blood and tranquilization, cool blood detumescence, to Portugal
Grape coccus, Escherichia coli and denaturation bacillus are inhibited.
Golden cypress：The effect of with sore swollen toxin, eczema itch are eliminated, there is stronger suppression to various types of shigella dysenteriaes
Make and use.
The coptis：Containing jamaicin, coptisine, worenine, palmatine and jateorrhizine etc., there is treatment eczema, wet
Sore, carbuncle swells furunculosis, the effect of antibacterial, antiviral anti-inflammatory and anti-cerebral ischemia.Golden cypress and the coptis have the function that Synergistic antimicrobial.
Cloves：Main component is eugenol, aceteugenol, carypohyllene, vanillic aldehyde and ester, for pathogenic fungus, Portugal
Grape coccus, shigella dysenteriae, Escherichia coli etc. have inhibitory action.
The root of herbaceous peony：Main component is root containing Paeoniflorin, oxidized paeoniflorin glycosides, Albiflorin, benzoylpaeoniflorin, Paeoniflorin member
Ketone, Paeonolide and Paeonol etc., there is smooth skin, anti-inflammation detumescence, treatment acne, anti-aging.
Rheum officinale：With purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow, carbuncle swells furunculosis, gingivitis, purging intense heat and detonicating the effect of.
Chrysanthemum indicum：Rich in flavonoids, half terpenes, polysaccharide, alantol, amino acid and trace element, there is anti-inflammatory, antioxygen
Change, the activity of Repercusion analgesia, have to staphylococcus aureus, shigella dysenteriae, EHEC, typhoid bacillus etc. and suppress energy
Power.
Purslane：Cure mainly dermatitis, enteritis, bacillary dysentery, treat pyogenic infections from tumour or sore, damage by worms bite, eczema, appendicitis, hookworm disease,
Banding spore rash and functional uterine bleeding, to Escherichia coli, typhoid bacillus, staphylococcus aureus and Du small bifurcation spore moss bacterium of Yang Shi
It is inhibited etc. pathogenic dermatophyte.
The capsule of weeping forsythia：The effect of with clearing heat and detoxicating, dispersing swelling and dissipating binds, to typhoid bacillus, paratyphosum Bacterium, Escherichia coli, dysentery
The various bacterias such as bacillus, corynebacterium diphtheriae, comma bacillus, staphylococcus, streptococcus are respectively provided with inhibitory action.
Cordate houttuynia：There is clearing heat and detoxicating, inducing diuresis to remove edema, for treating pneumonia, lung abscess, hot dysentery, malaria, water
Swollen, gonorrhoea, leukorrhea, carbuncle swells, hemorrhoid, prolapse of the anus, eczema, the favus of the scalp, mange etc., to staphylococcus aureus, staphylococcus albus, molten
Courageous and upright streptococcus, Diplococcus pneumopniae, micrococcus catarrhalis, corynebacterium diphtheriae, proteus, shigella dysenteriae, bacillus enteritidis etc. are respectively provided with not
With the inhibitory action of degree.
Fortune paulownia flower：Containing ethers and alcohols, for treating inflammation, viral infection, tinea of feet and hands, boil and burn etc., to gold
Staphylococcus aureus and hay bacillus have inhibition.
Garden burnet：With clearing heat and detoxicating, the clear yin-nourishing of training, healing up sore and subduing swelling and other effects.
Lemon grass (Cymbopogon citratus) essential oil：, can be high rich in natural constituents such as geranial, neral, geraniol, citronellal and citronellols
Effect is a kind of natural bactericide, preservative and antiphlogistic to pathogenic bacteria such as anti-Staphylococcus aureus and/or aspergillus nigers.
Tea tree ethereal oil：Rich in monoterpene, 1.8 cineols, niaouli alkene, carypohyllene, cadinene and terpinenes tetrol
Deng natural constituent, there is antifungi, antiviral, anti-inflammatory and other effects, can quickly penetrate into hair follicle, improve wound infection.
Wormwood essential oil：It is natural effectively rich in α-absinthol, monoterpene, cumarin, fanesol, wormwood alcohol and menthol etc.
Composition, there is anti-infective, antiviral, dissolving mucus, anti-inflammatory analgetic and other effects.
12 Chinese medical extracts and three kinds of plants essential oils of the present invention are common to coordinate under the fusion of tween, and collaboration is made
With, collect the elite of plant, penetrate deep into basal, there is gentle anti-acne, smoothing skin, conditioning viscera, preparation
Cosmetics are gently safe, not only can effectively remove acne, suppress the growth of bacterial fungus, and with reparation pockmark, nourishing
The effect of skin.
Preferably, the percentage by weight of the Chinese medical extract is 86-99%, for example, can be 86%, 87%, 88%,
89%th, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99%, preferably 90-99%, further
Preferably 90-96%.
Preferably, the percentage by weight of the plants essential oil is 0.01-2%, for example, can be 0.01%, 0.1%,
0.2%th, 0.25%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1.0%, 1.1%, 1.2%,
1.3%th, 1.4%, 1.5%, 1.6%, 1.7%, 1.8%, 1.9% or 2.0%, preferably 0.6-2%, more preferably
0.6-1%.
Preferably, the percentage by weight of the tween is 0.9-12%, for example, can be 0.9%, 1%, 2%, 3%,
4%th, 5%, 6%, 7%, 8%, 9%, 10%, 11% or 12%, preferably 0.9-9%, more preferably 3.4-9%.
Preferably, the Chinese medical extract include the red sage root, golden cypress, the coptis, cloves, the root of herbaceous peony, rheum officinale, chrysanthemum indicum, purslane,
At least two combination in the capsule of weeping forsythia, cordate houttuynia, fortune paulownia flower or garden burnet, such as can be the combination of rheum officinale and fortune paulownia flower, the red sage root,
Golden cypress, the coptis, the capsule of weeping forsythia and the combination of garden burnet or the red sage root, golden cypress, the coptis, cloves, the root of herbaceous peony, rheum officinale, chrysanthemum indicum, purslane, the capsule of weeping forsythia,
The combination of cordate houttuynia, fortune paulownia flower and garden burnet, the preferably red sage root, golden cypress, the coptis, cloves, the root of herbaceous peony, rheum officinale, chrysanthemum indicum, purslane,
The capsule of weeping forsythia, cordate houttuynia, fortune paulownia flower and the combination of garden burnet.
Preferably, the plants essential oil include lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil or P-Cymene in any one or extremely
Few two kinds combination.
Preferably, the tween includes any one in polysorbas20, polysorbate60 or Tween 80.
Preferably, the composition is mainly prepared by the following raw material by mass percentage：
Chinese medical extract 90-99%
Plants essential oil 0.6-2%
Tween 0.9-9%.
Preferably, the composition is mainly prepared by the following raw material by mass percentage：
Chinese medical extract 90-99%
Plants essential oil 0.6-1%
Tween 3.4-9%.
Second aspect, the invention provides a kind of method for preparing composition as described in relation to the first aspect, including following step
Suddenly：
(1) pre-process：By each raw material mixed in equal amounts of Chinese medical extract, crush, sieving；
(2) homogeneous extracts：Chinese medicinal granule after crushing is placed in high pressure homogenizer, Extraction solvent is added, enters horizontal high voltage
Homogeneous extracts；
(3) concentrate and purify：Extract solution is filtered, concentrated, purified, decolourized, obtains decoction；
(4) it is concentrated and dried：Decoction is subjected to filtering and concentrating, is dried in vacuo, obtains Chinese medical extract；
(5) water oil fusion：Tween is added to plants essential oil, is then added in step (4) described Chinese medical extract, that is, makes
Obtain the composition.
Preferably, the mesh number of step (1) described sieving is 80-200 mesh, such as can be 80 mesh, 90 mesh, 100 mesh, 110
Mesh, 120 mesh, 130 mesh, 140 mesh, 150 mesh, 160 mesh, 170 mesh, 180 mesh, 190 mesh or 200 mesh, preferably 100 mesh.
Preferably, the feed liquid mass ratio of step (2) Chinese medicinal granule and the Extraction solvent is 1:(20-30), such as
Can be 1:20、1:21、1:22、1:23、1:24、1:25、1:26、1:27、1:28、1:29 or 1:30, preferably 1:30.
Preferably, step (2) described Extraction solvent is the combination of water and/or ethanol, preferably water and ethanol.
Preferably, the mass fraction of the ethanol is 30-95%, for example, can be 30%, 35%, 40%, 45%,
50%th, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90% or 95%, preferably 50-80%.
Preferably, step (2) the high-pressure homogeneous extraction time is 10-30min, for example, can be 10min, 11min,
12min、13min、14min、15min、16min、17min、18min、19min、20min、21min、22min、23min、
24min, 25min, 26min, 27min, 28min, 29min or 30min, preferably 20min.
Preferably, step (2) the high-pressure homogeneous extraction pressure is 10-30MPa, for example, can be 10MPa, 11MPa,
12MPa、13MPa、14MPa、15MPa、16MPa、17MPa、18MPa、19MPa、20MPa、21MPa、22MPa、23MPa、
24MPa, 25MPa, 26MPa, 27MPa, 28MPa, 29MPa or 30MPa, preferably 20MPa.
Preferably, step (3) filtering is filtered using ceramic membrane.
Preferably, the aperture of the ceramic membrane is 50-500nm, for example, can be 50nm, 100nm, 150nm, 200nm,
250nm, 300nm, 350nm, 400nm, 450nm or 500nm, preferably 200nm.
Preferably, step (3) concentration is concentrated using reverse osmosis membrane.
Preferably, the pressure of step (3) described concentration is 5-30bar, for example, can be 5bar, 8bar, 10bar,
12bar, 15bar, 18bar, 20bar, 22bar, 25bar, 28bar or 30bar, preferably 20bar.
Preferably, step (3) purifying is purified using macroporous resin column.
Preferably, the large aperture resin is D101 and/or AB-8 resin columns.
Preferably, the eluent of step (3) described purifying is ethanol water.
Preferably, the concentration of the ethanol water is 20-80%, for example, can be 20%, 25%, 30%, 35%,
40%th, 45%, 50%, 55%, 60%, 65%, 70%, 75% or 80%, preferably 50%.
Preferably, step (3) decolouring is decolourized using activated carbon.
Preferably, the mass/volume ratio (w/v) of the activated carbon is 5-10%, for example, can be 5%, 6%, 7%,
8%th, 9% or 10%, preferably 8%.
Preferably, step (4) the vacuum drying temperature is 50-70 DEG C, for example, can be 50 DEG C, 51 DEG C, 52 DEG C, 53
℃、54℃、55℃、56℃、57℃、58℃、59℃、60℃、61℃、62℃、63℃、64℃、65℃、66℃、67℃、68
DEG C, 69 DEG C or 70 DEG C, preferably 60 DEG C.
The third aspect, the invention provides a kind of composition as described in relation to the first aspect answering in acne-eliminating cosmetic is prepared
With.
Preferably, the addition of the composition is 5-50%, for example, can be 5%, 10%, 15%, 20%, 25%,
30%th, 35%, 40%, 45% or 50%, preferably 20-30%.
Preferably, the formulation of the acne-eliminating cosmetic includes：In aqua, emulsion, spray, cream, elite or facial mask
Any one or at least two combination, preferably cream agent.
Compared with prior art, the present invention has the advantages that：
(1) composite formula of the invention is reasonable, 12 Chinese medical extracts and three kinds of plants essential oil Synergistics, massive planting
The elite of thing, penetrates deep into basal, notable to the inhibitory action of propionibacterium acnes, and antibacterial circle diameter is up to
27.20mm；
(2) the anti-acne elite breast added with said composition is gentle non-stimulated, persistently can substantially reduce hoary hair using 28 days
Acne, blackhead, papule, tumour tubercle and warts quantity；
(3) anti-acne elite breast of the invention not only can effectively remove acne, suppress acne recurrence, and property is gentle,
The effect of with skin is nourished.
Embodiment
For the present invention technological means and its effect taken is expanded on further, the present invention is made with reference to embodiments into
Illustrate to one step.It is understood that embodiment described herein is used only for explaining the present invention, rather than to this hair
Bright restriction.
In the examples where no specific technique or condition is specified, according to the technology or condition described by document in the art,
Or carried out according to product description.Agents useful for same or the unreceipted production firm person of instrument, be can be by regular channel commercially available from
The conventional products of acquisition.
The composition of embodiment 1 (I)
Formula is shown in Table 1.
Table 1
Preparation method：
Traditional Chinese medicine extraction raw material is crushed, is well mixed, is placed in high pressure homogenizer, by feed liquid quality after crossing 100 mesh sieves
Than for 1:30 add 50% ethanol, high pressure homogenization method 20min, extract pressure 20MPa, after extract solution is centrifuged, use
200nm ceramic membrane filter, then the 15% of original volume is concentrated under 20bar pressure with reverse osmosis membrane, upper resin model is
D101 macroporous resin column is purified, and is eluted with the ethanol water that concentration is 50% to colourless, collection eluent, with 8%
(w/v) activated carbon decolorizing, the micro porous filtration for being 200nm with aperture, filtrate is concentrated into is with the mass ratio of traditional Chinese medicine composite
1:3,60 DEG C of vacuum drying obtain Chinese medical extract, and after adding the mixed liquor of tween and plants essential oil, the combination is prepared
Thing.
The composition of embodiment 2 (II)
Formula is shown in Table 2.
Table 2
Preparation method：
Traditional Chinese medicine extraction raw material is crushed, is well mixed, is placed in high pressure homogenizer, by feed liquid quality after crossing 150 mesh sieves
Than for 1:30 add 80% ethanol, high pressure homogenization method 25min, extract pressure 20MPa, after extract solution is centrifuged, use
350nm ceramic membrane filter, then the 15% of original volume is concentrated under 25bar pressure with reverse osmosis membrane, upper resin model is
AB-8 macroporous resin column is purified, and is eluted with the ethanol water that concentration is 50% to colourless, collection eluent, with 8%
(w/v) activated carbon decolorizing, the micro porous filtration for being 350nm with aperture, filtrate is concentrated into is with the mass ratio of traditional Chinese medicine composite
1:3,65 DEG C of vacuum drying obtain Chinese medical extract, and after adding the mixed liquor of tween and plants essential oil, the combination is prepared
Thing.
The composition of embodiment 3 (III)
Formula is shown in Table 3.
Table 3
Preparation method：
Traditional Chinese medicine extraction raw material is crushed, is well mixed, is placed in high pressure homogenizer, by feed liquid mass ratio after crossing 80 mesh sieves
For 1:20 add 30% ethanol, high pressure homogenization method 10min, extract pressure 30MPa, after extract solution is centrifuged, use 50nm
Ceramic membrane filter, then the 10% of original volume is concentrated under 5bar pressure with reverse osmosis membrane, upper resin model is D101's
Macroporous resin column is purified, and is eluted with the ethanol water that concentration is 20% to colourless, collection eluent, living with 5% (w/v)
Property carbon decoloring, the micro porous filtration for being 50nm with aperture, filtrate be concentrated into the mass ratio of traditional Chinese medicine composite be 1:2,70 DEG C
Vacuum drying obtains Chinese medical extract, and after adding the mixed liquor of tween and plants essential oil, the composition is prepared.
The composition of embodiment 4 (IV)
Formula is shown in Table 4.
Table 4
Preparation method：
Traditional Chinese medicine extraction raw material is crushed, is well mixed, is placed in high pressure homogenizer, by feed liquid quality after crossing 200 mesh sieves
Than for 1:20 add 95% ethanol, high pressure homogenization method 30min, extract pressure 10MPa, after extract solution is centrifuged, use
500nm ceramic membrane filter, then the 20% of original volume is concentrated under 30bar pressure with reverse osmosis membrane, upper resin model is
AB-8 macroporous resin column is purified, and is eluted with the ethanol water that concentration is 80% to colourless, collection eluent, with 10%
(w/v) activated carbon decolorizing, the micro porous filtration for being 500nm with aperture, filtrate is concentrated into is with the mass ratio of traditional Chinese medicine composite
1:5,50 DEG C of vacuum drying obtain Chinese medical extract, and after adding the mixed liquor of tween and plants essential oil, the combination is prepared
Thing.
Comparative example 1
Compared with Example 1, the formula of the composition of comparative example 1 is shown in Table 5, and other preparation process are same as Example 1.
Table 5
Comparative example 2
Compared with Example 1, the formula of the composition of comparative example 2 is shown in Table 6, and said composition is mixed by polysorbas20 and plants essential oil
Conjunction forms.
Table 6
Comparative example 3
Compared with Example 1, the formula of the composition of comparative example 3 is shown in Table 7, and other preparation process are same as Example 1.
Table 7
In-vitro antibacterial Drug sensitivity is tested
The experiment of in-vitro antibacterial Drug sensitivity refers to determine the ability that medicine is antibacterial or sterilizes in vitro, of the invention to use
Odontothrips loti, judge inhibitory action of the composition to propionibacterium acnes of embodiment and comparative example.
Comprise the following steps that：Under aseptic condition, draw 200 μ L propionibacterium acnes uniform suspensions and be coated on flat board culture
On base, each culture medium moderate distance steadily places 3 sterile Oxford cups；0.1mL is added dropwise respectively to Oxford cup by embodiment 1-4
The sample solution for being 0.1g/mL with the concentration that comparative example 1-3 composition configures, 37 DEG C of Anaerobic culturels 2-5 days, removes Oxford
Cup, with the diameter of each inhibition zone of slide measure accurate measuring, compares fungistatic effect.
The antimicrobial susceptibility of composition, criterion reference table 8 are judged according to the size of antibacterial circle diameter.
The drug sensitivity assay criterion of table 8
| Antibacterial circle diameter (mm) | Susceptibility |
| More than 20 | It is extremely quick |
| 15-20 | Gao Min |
| 10-14 | In it is quick |
| 1-10 | Muting sensitive |
| 0 | It is unwise |
Experimental result is shown in Table 9.
The anti-acne Propionibacterium experimental result of table 9
| Numbering | Bacterial concentration (cfu/g) | Antibacterial circle diameter (mm) | Susceptibility |
| Embodiment 1 | 105-106 | 27.20 | It is extremely quick |
| Embodiment 2 | 105-106 | 26.72 | It is extremely quick |
| Embodiment 3 | 105-106 | 25.26 | It is extremely quick |
| Embodiment 4 | 105-106 | 25.17 | It is extremely quick |
| Comparative example 1 | 105-106 | 14.13 | In it is quick |
| Comparative example 2 | 105-106 | 11.36 | In it is quick |
| Comparative example 3 | 105-106 | 18.01 | Gao Min |
Contrasted from embodiment 1-4, when composition includes the red sage root 8%, golden cypress 8%, the coptis 8%, cloves 8%, the root of herbaceous peony
8%th, rheum officinale 8%, chrysanthemum indicum 8%, purslane 8%, the capsule of weeping forsythia 8%, cordate houttuynia 8%, fortune paulownia flower 8%, garden burnet 8%, lemon grass (Cymbopogon citratus) essence
When oil 0.2%, tea tree ethereal oil 0.2% and P-Cymene 0.2%, there is most strong fungistatic effect, Chinese medicine extract and plant essence
Obvious cooperative effect is shown after oil compounding, to the susceptibility highest of propionibacterium acnes, antibacterial circle diameter is up to
27.20mm。
Compared with Example 1, the composition of comparative example 1 only includes 12 Chinese medical extracts, and bacteriostasis is remarkably decreased, suppression
Bacterium loop diameter is 14.13mm, to propionibacterium acnes medium sensitivity；The composition of comparative example 2 only includes 3 kinds of plants essential oils, suppression
Bacterium ability is most weak, antibacterial circle diameter only 11.36mm, low to propionibacterium acnes susceptibility；The weight hundred of the composition of comparative example 3
Dividing ratio, bacteriostasis substantially weakens outside the scope of protection of present invention.
Embodiment 5
Anti-acne elite breast formula containing composition (I) is shown in Table 10.
The anti-acne elite of table 10 breast formula
Preparation method is as follows：
(1) A phase materials are well mixed, heating stirring is to 80-85 DEG C；
(2) B phase materials are well mixed, heating stirring is to 80-85 DEG C；
(3) B phase materials are added in A phase materials, with 4000r/min homogeneous 3-5min；
(4) 5 minutes are incubated, water-bath cooling is cooled to 30-35 DEG C；
(5) stirred with 1000r/min speed, sequentially add C phases and D phase materials, stir,
Discharge after the assay was approved.
Embodiment 6
Compared with Example 5, the addition of composition is 30%, and other conditions are same as Example 5.
Embodiment 7
Compared with Example 5, the addition of composition is 5%, and other conditions are same as Example 5.
Embodiment 8
Compared with Example 5, the addition of composition is 50%, and other conditions are same as Example 5.
Comparative example 4
Compared with Example 5, the addition of plant composition is 1%, and other conditions are same as Example 5.
Comparative example 5
Compared with Example 5, the addition of plant composition is 55%, and other conditions are same as Example 5.
Safety evaluatio is tested
Example 5-8, comparative example 4-5 and commercially available competing product (the whelk conditioning elite breast of the composition containing salicylic acid) are pacified
Full property evaluation test.Volunteer of 30 ages 22-40 year is chosen, the spot examination adhesive tape equipped with 0.03mL samples is affixed on aspiration
Before person on the normal skin of left arm, while light pressing room expulsion air, the coyote hole of material is not loaded into as blank control.Every 24
Hour patch skin once, continues 7 days, opens and checked in paster half an hour after according to CTFA guides (1981).Standard of perfection
11 are shown in Table, test result is shown in Table 12.
The standard of perfection of table 11
The patch experimental results of table 12
| Numbering | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| Embodiment 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Embodiment 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Embodiment 7 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Embodiment 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Comparative example 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Comparative example 5 | 0 | 0 | 0 | 0 | 0 | ± | ± |
| Competing product | 0 | ± | ± | ± | ± | + | ± |
| Blank control | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Embodiment 5-8 anti-acne elite breast is substantially non-stimulated, and comparative example 4-5 composition addition is protected in application claims
Outside the scope of shield, only there are 2 slight erythema in 7 tests in comparative example 5, and addition exceeds claimed scope and has one
Fixed excitant, and there is multiple adverse reaction in the whelk of commercially available salicylic acid composition conditioning elite breast, having to skin stimulates
Property.
Suppress propionibacterium acnes efficacy assessments
Choosing face has obvious acne, and in introduction stage or inflammatory phase, and facial area skin belongs to easy long acne type
Volunteer totally 30, the age, men and women half and half 20-30 year, carried out half face test.By dermatologist to volunteer or so face
Whiteheads, blackhead, papule, the acne of 5 ranks of tumour tubercle and warts carry out the mark and number statistical of number.
Embodiment 5-8, comparative example 4-5 and commercially available competing product (the whelk conditioning elite breast of the composition containing salicylic acid) are applied to
Volunteer affected part, application area is more than ill area, in order to not influence the study and work of patient, when can utilize sleep at night
Between treated, morning get up after use warm water cleaning.The test of half face continues 28 days, and the 14th day of experiment and the 28th day
Paid a return visit.
Experimental result is shown in Table 13-1 and table 13-2.
Table 13-1 tries out evaluation result (the 14th day)
Table 13-2 tries out evaluation result (the 28th day)
Embodiment 5-8 anti-acne elite breast has compared with the whelk conditioning elite breast of commercial aqueous poplar acid composition to acne
Significant inhibitory action, in 28 days used, Whiteheads, blackhead, papule, the quantity of tumour tubercle and warts have
It is remarkably decreased, avoids the recurrence of acne；Comparative example 4-5 anti-acne elite breast equally to Whiteheads, blackhead, papule,
Tumour tubercle and warts are inhibited, though the effect of comparative example 5 is good, certain excitant be present, so composition addition
Outside the scope of protection of present invention, security and effect are not as good as embodiment 5-8.
In summary, composite formula of the invention is reasonable, Chinese medical extract and plants essential oil Synergistic, penetrates deep into
Basal, there is tetchy inhibitory action to propionibacterium acnes, the gentle nothing of anti-acne elite breast added with said composition
Stimulate, persistently can substantially reduce Whiteheads, blackhead, papule, tumour tubercle and warts quantity using 28 days.
Applicant states that the present invention illustrates the method detailed of the present invention, but not office of the invention by above-described embodiment
It is limited to above-mentioned method detailed, that is, does not mean that the present invention has to rely on above-mentioned method detailed and could implemented.Art
Technical staff it will be clearly understood that any improvement in the present invention, equivalence replacement and auxiliary element to each raw material of product of the present invention
Addition, selection of concrete mode etc., within the scope of all falling within protection scope of the present invention and disclosing.
Claims (10)
1. a kind of composition, it is characterised in that the composition is mainly prepared by the following raw material by mass percentage：
Chinese medical extract 86-99%
Plants essential oil 0.01-2%
Tween 0.9-12%.
2. composition according to claim 1, it is characterised in that the Chinese medical extract include the red sage root, golden cypress, the coptis,
At least two combination in cloves, the root of herbaceous peony, rheum officinale, chrysanthemum indicum, purslane, the capsule of weeping forsythia, cordate houttuynia, fortune paulownia flower or garden burnet；
Preferably, the plants essential oil includes any one in lemon grass (Cymbopogon citratus) essential oil, tea tree ethereal oil or P-Cymene or at least two
The combination of kind；
Preferably, the tween includes any one in polysorbas20, polysorbate60 or Tween 80.
3. composition according to claim 1 or 2, it is characterised in that the composition is by mass percentage mainly by such as
Lower raw material is prepared：
Chinese medical extract 90-99%
Plants essential oil 0.6-2%
Tween 0.9-9%.
4. according to the composition described in claim any one of 1-3, it is characterised in that the composition is main by mass percentage
It is prepared by the following raw material：
Chinese medical extract 90-96%
Plants essential oil 0.6-1%
Tween 3.4-9%.
A kind of 5. method for preparing the composition as described in claim any one of 1-4, it is characterised in that comprise the following steps：
(1) pre-process：By each raw material mixed in equal amounts of Chinese medical extract, crush, sieving；
(2) homogeneous extracts：Chinese medicinal granule after crushing is placed in high pressure homogenizer, adds Extraction solvent, is carried out high-pressure homogeneous
Extraction；
(3) concentrate and purify：Extract solution is filtered, concentrated, purified, decolourized, obtains decoction；
(4) it is concentrated and dried：Decoction is subjected to filtering and concentrating, is dried in vacuo, obtains Chinese medical extract；
(5) water oil fusion：Tween is added to plants essential oil, is then added in step (4) described Chinese medical extract, that is, institute is made
State composition.
6. according to the method for claim 5, it is characterised in that the mesh number of step (1) described sieving is 80-200 mesh, preferably
For 100 mesh.
7. the method according to claim 5 or 6, it is characterised in that step (2) Chinese medicinal granule and the Extraction solvent
Feed liquid mass ratio be 1:(20-30), preferably 1:30；
Preferably, step (2) described Extraction solvent is the combination of water and/or ethanol, preferably water and ethanol；
Preferably, the mass fraction of the ethanol is 30-95%, preferably 50-80%；
Preferably, the time of step (2) described high pressure homogenization method is 10-30min, preferably 20min；
Preferably, the pressure of step (2) described high pressure homogenization method is 10-30MPa, preferably 20MPa.
8. according to the method described in claim any one of 5-7, it is characterised in that step (3) filtering is entered using ceramic membrane
Row filtering；
Preferably, the aperture of the ceramic membrane is 50-500nm, preferably 200nm；
Preferably, step (3) concentration is concentrated using reverse osmosis membrane；
Preferably, the pressure of step (3) described concentration is 5-30bar, preferably 20bar；
Preferably, step (3) purifying is purified using macroporous resin column；
Preferably, the large aperture resin is D101 and/or AB-8 resin columns；
Preferably, the eluent of step (3) described purifying is ethanol water；
Preferably, the concentration of the ethanol water is 20-80%, preferably 50%；
Preferably, step (3) decolouring is decolourized using activated carbon；
Preferably, the mass/volume ratio of the activated carbon is 5-10%, preferably 8%.
9. according to the method described in claim any one of 5-8, it is characterised in that step (4) the vacuum drying temperature is
50-70 DEG C, preferably 60 DEG C.
A kind of 10. application of composition as described in claim any one of 1-4 in acne-eliminating cosmetic is prepared；
Preferably, the addition of the composition is 5-50%, preferably 20-30%；
Preferably, the formulation of the acne-eliminating cosmetic includes：It is any in aqua, emulsion, spray, cream, elite or facial mask
It is a kind of or at least two combination, preferably cream agent.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010173A (en) * | 2018-09-06 | 2018-12-18 | 王国香 | A kind of multi-functional skin care is spraying and preparation method thereof |
| CN109363987A (en) * | 2018-11-15 | 2019-02-22 | 无限极（中国）有限公司 | Radix Sangusorbae extract and its preparation process and application |
| CN109498536A (en) * | 2018-12-15 | 2019-03-22 | 横琴智库转化医学有限公司 | A kind of cosmetic composition containing Chinese medicine extract |
| CN111658586A (en) * | 2020-06-29 | 2020-09-15 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with mite and acne removing functions and preparation method and application thereof |
| CN112870131A (en) * | 2021-03-31 | 2021-06-01 | 深圳市萱嘉生物科技有限公司 | Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof |
| CN113081928A (en) * | 2021-04-29 | 2021-07-09 | 云南赛森生物科技有限公司 | Plant bacteriostatic gel and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380840A (en) * | 2015-11-13 | 2016-03-09 | 上海辰山植物园 | Chinese herbal medicine composition for acne removal restoration and preparation method thereof |
| CN106344460A (en) * | 2016-10-31 | 2017-01-25 | 青岛海之源智能技术有限公司 | Special moisturizing and acne-removing face cream for acne-prone skin and preparation method thereof |
-
2017
- 2017-09-30 CN CN201710919255.1A patent/CN107519100A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105380840A (en) * | 2015-11-13 | 2016-03-09 | 上海辰山植物园 | Chinese herbal medicine composition for acne removal restoration and preparation method thereof |
| CN106344460A (en) * | 2016-10-31 | 2017-01-25 | 青岛海之源智能技术有限公司 | Special moisturizing and acne-removing face cream for acne-prone skin and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| 常青: "《常青内妇科临证精华》", 31 December 2016, 中国中医药出版社 * |
| 梅全喜: "《艾叶的研究与应用》", 31 October 2013, 中国中医药出版社 * |
| 王巍: "《问题肌肤自救魔法》", 31 December 2012, 湖南科学技术出版社 * |
| 王昌涛等: "《化妆品植物添加剂的开发与应用》", 30 April 2013, 中国轻工业出版社 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010173A (en) * | 2018-09-06 | 2018-12-18 | 王国香 | A kind of multi-functional skin care is spraying and preparation method thereof |
| CN109363987A (en) * | 2018-11-15 | 2019-02-22 | 无限极（中国）有限公司 | Radix Sangusorbae extract and its preparation process and application |
| CN109363987B (en) * | 2018-11-15 | 2022-01-11 | 无限极（中国）有限公司 | Sanguisorba extract and preparation process and application thereof |
| CN109498536A (en) * | 2018-12-15 | 2019-03-22 | 横琴智库转化医学有限公司 | A kind of cosmetic composition containing Chinese medicine extract |
| CN111658586A (en) * | 2020-06-29 | 2020-09-15 | 广州环亚化妆品科技有限公司 | Traditional Chinese medicine composition with mite and acne removing functions and preparation method and application thereof |
| CN112870131A (en) * | 2021-03-31 | 2021-06-01 | 深圳市萱嘉生物科技有限公司 | Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof |
| CN113081928A (en) * | 2021-04-29 | 2021-07-09 | 云南赛森生物科技有限公司 | Plant bacteriostatic gel and preparation method and application thereof |
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