CN112870131A - Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof - Google Patents
Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof Download PDFInfo
- Publication number
- CN112870131A CN112870131A CN202110350920.6A CN202110350920A CN112870131A CN 112870131 A CN112870131 A CN 112870131A CN 202110350920 A CN202110350920 A CN 202110350920A CN 112870131 A CN112870131 A CN 112870131A
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- CN
- China
- Prior art keywords
- traditional chinese
- chinese medicine
- medicine extract
- acne removing
- removing effect
- Prior art date
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- Pending
Links
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 48
- 206010000496 acne Diseases 0.000 title claims abstract description 48
- 239000000203 mixture Substances 0.000 title claims abstract description 45
- 239000003814 drug Substances 0.000 title claims abstract description 39
- 230000000694 effects Effects 0.000 title claims abstract description 38
- 239000000284 extract Substances 0.000 title claims abstract description 38
- 238000002360 preparation method Methods 0.000 title claims abstract description 19
- 239000000463 material Substances 0.000 claims abstract description 16
- 244000118350 Andrographis paniculata Species 0.000 claims abstract description 14
- 244000146462 Centella asiatica Species 0.000 claims abstract description 14
- 235000004032 Centella asiatica Nutrition 0.000 claims abstract description 14
- 241000037740 Coptis chinensis Species 0.000 claims abstract description 13
- 235000011135 Salvia miltiorrhiza Nutrition 0.000 claims abstract description 13
- 241000246044 Sophora flavescens Species 0.000 claims abstract description 6
- 241000304195 Salvia miltiorrhiza Species 0.000 claims abstract 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 44
- 239000002904 solvent Substances 0.000 claims description 40
- 230000005496 eutectics Effects 0.000 claims description 37
- 239000007864 aqueous solution Substances 0.000 claims description 28
- 239000006228 supernatant Substances 0.000 claims description 25
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 18
- 239000003480 eluent Substances 0.000 claims description 18
- 238000005303 weighing Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 14
- 238000002791 soaking Methods 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 7
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 6
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims description 6
- 229960003237 betaine Drugs 0.000 claims description 6
- 238000010828 elution Methods 0.000 claims description 6
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 6
- 229920005989 resin Polymers 0.000 claims description 6
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 5
- 239000000243 solution Substances 0.000 claims description 5
- 238000005119 centrifugation Methods 0.000 claims description 4
- 241000746375 Andrographis Species 0.000 claims description 3
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 239000012676 herbal extract Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 abstract description 8
- 239000002537 cosmetic Substances 0.000 abstract description 5
- 208000024891 symptom Diseases 0.000 abstract description 4
- 206010070834 Sensitisation Diseases 0.000 abstract description 3
- 230000003115 biocidal effect Effects 0.000 abstract description 3
- 229940088597 hormone Drugs 0.000 abstract description 3
- 239000005556 hormone Substances 0.000 abstract description 3
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- 230000008313 sensitization Effects 0.000 abstract description 3
- 230000008961 swelling Effects 0.000 description 20
- 238000012360 testing method Methods 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 description 8
- 244000132619 red sage Species 0.000 description 8
- 210000003491 skin Anatomy 0.000 description 8
- 241000218202 Coptis Species 0.000 description 6
- 235000002991 Coptis groenlandica Nutrition 0.000 description 6
- -1 alkaloid compounds Chemical class 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 238000000605 extraction Methods 0.000 description 6
- 238000012795 verification Methods 0.000 description 5
- IBGBGRVKPALMCQ-UHFFFAOYSA-N 3,4-dihydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1O IBGBGRVKPALMCQ-UHFFFAOYSA-N 0.000 description 4
- BOJKULTULYSRAS-OTESTREVSA-N Andrographolide Chemical compound C([C@H]1[C@]2(C)CC[C@@H](O)[C@]([C@H]2CCC1=C)(CO)C)\C=C1/[C@H](O)COC1=O BOJKULTULYSRAS-OTESTREVSA-N 0.000 description 4
- XDVZNDLANFJOQR-UHFFFAOYSA-N Coptisine Natural products O=Cc1c2OCOc2ccc1C=C3/NCCc4cc5OCOc5cc34 XDVZNDLANFJOQR-UHFFFAOYSA-N 0.000 description 4
- 229930183118 Tanshinone Natural products 0.000 description 4
- 229930013930 alkaloid Natural products 0.000 description 4
- ASLUCFFROXVMFL-UHFFFAOYSA-N andrographolide Natural products CC1(CO)C(O)CCC2(C)C(CC=C3/C(O)OCC3=O)C(=C)CCC12 ASLUCFFROXVMFL-UHFFFAOYSA-N 0.000 description 4
- 230000003110 anti-inflammatory effect Effects 0.000 description 4
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 description 4
- 210000004207 dermis Anatomy 0.000 description 4
- 230000008034 disappearance Effects 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 206010061218 Inflammation Diseases 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 230000004054 inflammatory process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
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- 231100000475 skin irritation Toxicity 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- PAFLSMZLRSPALU-MRVPVSSYSA-N (2R)-3-(3,4-dihydroxyphenyl)lactic acid Chemical compound OC(=O)[C@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-MRVPVSSYSA-N 0.000 description 2
- QDZOEBFLNHCSSF-PFFBOGFISA-N (2S)-2-[[(2R)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2R)-2-amino-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pentanediamide Chemical compound C([C@@H](C(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](N)CCCNC(N)=N)C1=CC=CC=C1 QDZOEBFLNHCSSF-PFFBOGFISA-N 0.000 description 2
- YLRXAIKMLINXQY-ZDUSSCGKSA-O (S)-magnoflorine Chemical compound C1=C(OC)C(O)=C2C3=C(O)C(OC)=CC=C3C[C@@H]3[N+](C)(C)CCC1=C23 YLRXAIKMLINXQY-ZDUSSCGKSA-O 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- PAFLSMZLRSPALU-QMMMGPOBSA-N Danshensu Natural products OC(=O)[C@@H](O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-QMMMGPOBSA-N 0.000 description 2
- 102100037850 Interferon gamma Human genes 0.000 description 2
- 108010074328 Interferon-gamma Proteins 0.000 description 2
- WYQVAPGDARQUBT-FGWHUCSPSA-N Madecassol Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(CC[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O WYQVAPGDARQUBT-FGWHUCSPSA-N 0.000 description 2
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 description 2
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 description 2
- KYEAXNAYHSCLMT-CVVGWEDFSA-N Magnoflorine Natural products C[C@H]1OC=C2[C@@H]3[C@@H]1CN4CCc5c([nH]c6ccccc56)[C@@H]4[C@@H]3OC2=O KYEAXNAYHSCLMT-CVVGWEDFSA-N 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 102100024304 Protachykinin-1 Human genes 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 240000007164 Salvia officinalis Species 0.000 description 2
- PAFLSMZLRSPALU-UHFFFAOYSA-N Salvianic acid A Natural products OC(=O)C(O)CC1=CC=C(O)C(O)=C1 PAFLSMZLRSPALU-UHFFFAOYSA-N 0.000 description 2
- YMGFTDKNIWPMGF-UCPJVGPRSA-N Salvianolic acid A Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C(=C(O)C(O)=CC=1)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 YMGFTDKNIWPMGF-UCPJVGPRSA-N 0.000 description 2
- YMGFTDKNIWPMGF-QHCPKHFHSA-N Salvianolic acid A Natural products OC(=O)[C@H](Cc1ccc(O)c(O)c1)OC(=O)C=Cc2ccc(O)c(O)c2C=Cc3ccc(O)c(O)c3 YMGFTDKNIWPMGF-QHCPKHFHSA-N 0.000 description 2
- 241000193998 Streptococcus pneumoniae Species 0.000 description 2
- 101800003906 Substance P Proteins 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- WYQVAPGDARQUBT-XCWYDTOWSA-N asiaticoside Natural products O=C(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@H](O)[C@H](O)[C@H](O[C@H]3[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O3)[C@@H](CO)O2)O1)[C@@]12[C@@H]([C@@H](C)[C@H](C)CC1)C=1[C@](C)([C@@]3(C)[C@@H]([C@@]4(C)[C@H]([C@@](CO)(C)[C@@H](O)[C@H](O)C4)CC3)CC=1)CC2 WYQVAPGDARQUBT-XCWYDTOWSA-N 0.000 description 2
- 229940022757 asiaticoside Drugs 0.000 description 2
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 description 2
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 description 2
- 229940093265 berberine Drugs 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000004856 capillary permeability Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- XYHOBCMEDLZUMP-UHFFFAOYSA-N coptisine Chemical compound C1=C2C=C(C3=C(C=C4OCOC4=C3)CC3)[N+]3=CC2=C2OCOC2=C1 XYHOBCMEDLZUMP-UHFFFAOYSA-N 0.000 description 2
- 229930004069 diterpene Natural products 0.000 description 2
- FPJQGFLUORYYPE-UHFFFAOYSA-N epiberberine Chemical compound C1=C2C=C(C3=C(C=C(C(=C3)OC)OC)CC3)[N+]3=CC2=C2OCOC2=C1 FPJQGFLUORYYPE-UHFFFAOYSA-N 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 229930003944 flavone Natural products 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 235000011949 flavones Nutrition 0.000 description 2
- 229930003935 flavonoid Natural products 0.000 description 2
- 235000017173 flavonoids Nutrition 0.000 description 2
- 150000002215 flavonoids Chemical class 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229930013397 isoquinoline alkaloid Natural products 0.000 description 2
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 229940090813 madecassoside Drugs 0.000 description 2
- 239000002075 main ingredient Substances 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- SCOAVUHOIJMIBW-UHFFFAOYSA-N phenanthrene-1,2-dione Chemical class C1=CC=C2C(C=CC(C3=O)=O)=C3C=CC2=C1 SCOAVUHOIJMIBW-UHFFFAOYSA-N 0.000 description 2
- 230000013823 prenylation Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 229960003371 protocatechualdehyde Drugs 0.000 description 2
- 235000005412 red sage Nutrition 0.000 description 2
- 229930183842 salvianolic acid Natural products 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 241000167550 Centella Species 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 241000186427 Cutibacterium acnes Species 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 208000001126 Keratosis Diseases 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 239000003098 androgen Substances 0.000 description 1
- 229940030486 androgens Drugs 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000374 eutectic mixture Substances 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 230000001969 hypertrophic effect Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 229940055019 propionibacterium acne Drugs 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the technical field of cosmetics, and discloses a traditional Chinese medicine extract composition with an acne removing effect and a preparation method thereof, wherein the composition comprises extracts of salvia miltiorrhiza, sophora flavescens, coptis chinensis, centella asiatica and andrographis paniculata, and the content of each medicinal material is as follows according to the dry weight percentage of the medicinal materials: 1-30% of salvia miltiorrhiza, 1-30% of radix sophorae flavescentis, 1-30% of coptis chinensis, 1-30% of centella asiatica and 1-30% of andrographis paniculata; the composition of the traditional Chinese medicine extract can realize multi-path antibiosis and antiphlogosis and relieve acne symptoms, is green and efficient, and does not contain hormones, so that irritation and sensitization of chemical preparations to skin are avoided.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a traditional Chinese medicine extract composition with an acne removing effect and a preparation method thereof.
Background
Acne is commonly known as acne, and is treated academically. Acne is a chronic inflammatory skin disease of hair follicles and sebaceous glands, and is also one of the most common diseases in the cosmetology dermatology department. After acne occurs, pigmentation, persistent erythema, depressed or hypertrophic scars are easily caused, the appearance is influenced, and the acne is a beautiful natural enemy.
The current acne research shows that the psychological pressure and the working pressure are increased; high oil and high sugar eating habits; stay up at night, and play bad daily work and rest such as mobile phones excessively; improper use of skin care products and cosmetics, etc., can lead to acne. Acne is not limited by age, and people of all ages, except adolescents in adolescence, may suffer from it. Therefore, alleviating and treating the acne problem is a hot spot of current cosmetic research.
The pathogenesis of acne is closely related to factors such as excessive sebum secretion, follicular sebaceous gland duct keratosis, blockage, propionibacterium acnes infection and inflammatory reaction. At present, a plurality of chemical acne removing products are available on the market, and most products are added with antibiotics, retinoic acid and androgens to achieve the treatment effect. However, such products are irritating and tend to cause skin discomfort during treatment. While concurrent hormonal therapy can alleviate and treat the acne problem and symptoms within a certain period of time, if improperly used, the condition is likely to be exacerbated. Therefore, the problem of skin acne is very worthy of research by adopting a new way and a new method.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine extract composition with an acne removing effect and a preparation method thereof, and aims to solve the problem that an acne removing product in the prior art is irritant.
In a first aspect, the application provides a preparation method of a traditional Chinese medicine extract composition with acne removing efficacy, which comprises the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing the salvia miltiorrhiza, the sophora flavescens, the coptis chinensis, the centella asiatica and the andrographis paniculata, wherein the contents of the medicinal materials are as follows according to the dry weight percentage of the medicinal materials: 1-30% of salvia miltiorrhiza, 1-30% of radix sophorae flavescentis, 1-30% of coptis chinensis, 1-30% of centella asiatica and 1-30% of andrographis paniculata; soaking the dry powder of the traditional Chinese medicine composition in the deep eutectic solvent aqueous solution obtained in the step S1 to obtain a mixed solution;
s3, purifying the mixed solution by using macroporous adsorption resin, and collecting eluent after elution;
s4, concentrating the eluent, adding 1, 3-butanediol, stirring uniformly, standing for 24 hours, and collecting the supernatant;
s5, centrifuging the supernatant to obtain a centrifugal supernatant, wherein the centrifugal supernatant contains the traditional Chinese medicine extract composition with the acne removing effect.
As an embodiment, step S2 specifically includes the following steps:
s21, weighing 1-30 parts of salvia miltiorrhiza, 1-30 parts of radix sophorae flavescentis, 1-30 parts of coptis chinensis, 1-30 parts of centella asiatica and 1-30 parts of common andrographis herb by taking grams as a unit, and weighing the total weight of all the weighed medicinal materials as a numerical value A;
s22, recording the volume of the deep eutectic solvent aqueous solution as a numerical value B in milliliters, wherein the volume ratio of the deep eutectic solvent aqueous solution is 10-95%;
s23, measuring a certain amount of deep eutectic solvent water solution to enable the value B to be 5-20 times of the value A;
s24, soaking and extracting the measured medicinal materials in a deep eutectic aqueous solvent for 2-48 hours each time for 1-3 times, and combining the mixed extracting solutions.
As an embodiment, in step S3, the eluent used for elution is 1, 3-butanediol aqueous solution, and the volume ratio of the 1, 3-butanediol aqueous solution is 5% -95%.
As an embodiment, step S4 specifically includes:
concentrating the eluate by 3-20 times, adding 1, 3-butanediol of 1-3 times of the volume of the eluate, stirring, standing for 24 hr, and collecting supernatant;
in one embodiment, in step S5, the centrifugation speed is 5000r/min-10000r/min, and the centrifugation time is 5-10 minutes.
In a second aspect, the application also provides a traditional Chinese medicine extract composition with acne removing efficacy, and the composition is prepared by the preparation method.
Compared with the prior art, the method has the following beneficial effects:
(1) the active ingredients of red sage root are mainly divided into two categories of fat-soluble and water-soluble. Wherein the fat-soluble component comprises phenanthrenequinone derivatives such as tanshinone; the water soluble components include protocatechualdehyde and danshensu. Wherein the fat-soluble tanshinone has antibacterial and antiinflammatory effects; the water-soluble salvianolic acid can resist oxidation and protect cells.
(2) The chemical components of the sophora flavescens mainly comprise two main classes of alkaloids and flavones, wherein the alkaloid compounds can obviously increase the secretion of IFN-gamma of HaCaT cells stimulated by substance P. Has effects of eliminating dampness and relieving itching; prenylation of flavonoids can enhance their antibacterial activity.
(3) The coptis contains various isoquinoline alkaloids, the content of berberine is the highest and is 5% -8%, and the coptis further contains coptisine, methyl coptisine, epiberberine, magnoflorine and the like, and the components enable the coptis to have obvious antibacterial and anti-inflammatory effects.
(4) Centella asiatica contains various triterpenes, and its main ingredients are asiaticoside and madecassoside. The skin-care product has the effects of tightening the connecting part of the epidermis and the dermis, softening the skin, promoting the formation of collagen in the dermis and tightening the skin.
(5) Andrographis paniculata Nees contain mainly diterpene lactones, wherein andrographolide is used as the substance basis of the main pharmacological activity of Andrographis paniculata Nees. The andrographolide components have effect in inhibiting Diplococcus pneumoniae, inhibiting capillary permeability increase due to inflammation, and improving exudation and edema.
(6) The traditional Chinese medicine extract composition with the acne removing effect is obtained by extracting the traditional Chinese medicines through a deep eutectic solvent, and can achieve multiple ways of antibiosis and antiphlogosis and relieve acne symptoms. The product is green and efficient, and does not contain hormones, so that irritation and sensitization of chemical preparations to skin are avoided.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The following describes the implementation of the present invention in detail with reference to specific embodiments.
Example 1
A traditional Chinese medicine extract composition with acne removing effect is weighed according to dry weight of medicinal materials and comprises 20 g of salvia miltiorrhiza, 20 g of sophora flavescens, 20 g of coptis chinensis, 20 g of centella and 20 g of common andrographis herb.
A preparation method of a traditional Chinese medicine extract composition with an acne removing effect specifically comprises the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing 20 g of salvia miltiorrhiza, 20 g of radix sophorae flavescentis, 20 g of coptis chinensis, 20 g of centella asiatica and 20 g of andrographis paniculata according to dry weight of medicinal materials, soaking and extracting the dry powder of the traditional Chinese medicine composition by 1000 ml of the deep eutectic solvent aqueous solution obtained in the step S1, wherein the volume ratio of the deep eutectic solvent aqueous solution is 50%, the extraction times are 1 time, and the mixed solution solvent is obtained after soaking for 12 hours each time;
s3, purifying with macroporous adsorption resin, eluting, collecting eluent, wherein the eluent for the eluting step is 50% 1, 3-butanediol aqueous solution.
S4, concentrating the eluent by 3 times, adding 1, 3-butanediol by 2 times, stirring uniformly, standing for 24 hours, and collecting the supernatant;
s5, centrifuging the supernatant at a speed of 5000r/min for 5min to obtain a centrifuged supernatant, wherein the centrifuged supernatant contains the traditional Chinese medicine extract composition with the acne removing effect.
Example 2
A preparation method of a traditional Chinese medicine extract composition with an acne removing effect specifically comprises the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing 25 g of salvia miltiorrhiza, 25 g of radix sophorae flavescentis, 20 g of coptis chinensis, 15 g of centella asiatica and 15 g of andrographis paniculata according to dry weight of medicinal materials, soaking and extracting the Chinese medicinal composition dry powder with 1500 ml of the deep eutectic solvent aqueous solution obtained in the step S1, wherein the volume ratio of the deep eutectic solvent aqueous solution is 60%, the extraction times are 2 times, and 24 hours of soaking each time is carried out to obtain a mixed solution solvent;
s3, purifying with macroporous adsorption resin, eluting, collecting eluent, wherein the eluent used in the elution step is 30% 1, 3-butanediol aqueous solution.
S4, concentrating the 6 times of eluent, adding 1.5 times of 1, 3-butanediol, stirring uniformly, standing for 24 hours, and collecting the supernatant;
s5, centrifuging the supernatant at 6000r/min for 8min to obtain a centrifuged supernatant, wherein the centrifuged supernatant contains the traditional Chinese medicine extract composition with the acne removing effect.
Example 3
A preparation method of a traditional Chinese medicine extract composition with an acne removing effect specifically comprises the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing 25 g of salvia miltiorrhiza, 25 g of radix sophorae flavescentis, 20 g of coptis chinensis, 15 g of centella asiatica and 15 g of andrographis paniculata according to dry weight of medicinal materials, soaking and extracting the dry powder of the traditional Chinese medicine composition by 2000 ml of the deep eutectic solvent aqueous solution obtained in the step S1, wherein the volume ratio of the deep eutectic solvent aqueous solution is 70%, the extraction times are 3 times, and 15 hours of soaking are carried out each time to obtain a mixed solution solvent;
s3, purifying with macroporous adsorption resin, eluting, collecting eluent, wherein the eluent for the eluting step is 60% 1, 3-butanediol aqueous solution.
S4, concentrating 10 times of eluent, adding 3 times of 1, 3-butanediol, uniformly stirring, standing for 24 hours, and collecting supernatant;
s5, centrifuging the supernatant at a speed of 10000r/min for 10min to obtain a centrifuged supernatant, wherein the centrifuged supernatant contains the traditional Chinese medicine extract composition with the acne removing effect.
Example 4
A preparation method of a traditional Chinese medicine extract composition with an acne removing effect specifically comprises the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing 15 g of salvia miltiorrhiza, 30 g of radix sophorae flavescentis, 10 g of coptis chinensis, 30 g of centella asiatica and 15 g of andrographis paniculata according to dry weight of medicinal materials, soaking and extracting the dry powder of the traditional Chinese medicine composition by 1200 ml of deep eutectic solvent aqueous solution obtained in the step S1, wherein the volume ratio of the deep eutectic solvent aqueous solution is 65%, the extraction times are 1 time, and 48 hours of soaking are carried out each time to obtain a mixed solution solvent;
s3, purifying with macroporous adsorption resin, eluting, collecting eluent, wherein the eluent used in the elution step is 10% 1, 3-butanediol aqueous solution.
S4, concentrating the eluent by 3 times, adding 1, 3-butanediol by 2 times, stirring uniformly, standing for 24 hours, and collecting the supernatant;
s5, centrifuging the supernatant at 8000r/min for 6min to obtain a centrifuged supernatant containing the Chinese medicinal extract composition with acne removing effect.
In order to verify the acne removing efficacy of the patent, the following experiments are further carried out:
the composition obtained in the above examples was subjected to an acute skin irritation test and a plurality of skin irritation tests, according to the skin irritation procedure of "2007 edition of cosmetic hygiene standards". The compositions obtained in the examples were then used for therapeutic tests, and the results of the tests were counted. The extracts obtained in example 1, example 2, example 3 and example 4 were respectively the herb extracts A, B, C, D, and the herb extract compositions obtained in the respective experimental examples were subjected to the following verification tests:
1. verification test I:
test subjects, 70, were enrolled and all subjects were asked to have a distinct inflamed pox in the same location on the cheek (determined in advance by the experimenter). The subjects cleaned the face with facial cleanser of the same brand before the experiment, and then applied the herbal extract a obtained in experimental example 1 to the cleaned pox uniformly, once a day, in the morning and at the evening, for a week. The tested part is observed before the sample is tried, on the first day of the trial, on the third day of the trial and after one week of the trial, and the number of people with different degrees of inflamed pox is recorded.
| Trial effect | Before trial | Trial day one | Trial for the third day | One week on trial |
| Severe red swelling and stabbing pain | 70 | 55 | 20 | 1 |
| Red and swollen without tingling | 0 | 10 | 10 | 1 |
| Slight red swelling without stabbing pain | 0 | 2 | 14 | 3 |
| Disappearance of red swelling | 0 | 3 | 26 | 65 |
The comprehensive experiment result shows that after one week of trial, the cure rate of the pox (the pox is from severe red swelling and stabbing pain is recovered to red swelling and disappears) is about 92.9 percent, so that the traditional Chinese medicine extract A has a good acne removing effect.
2. And (5) verification test II:
test subjects, 70, were enrolled and all subjects were asked to have a distinct inflamed pox in the same location on the cheek (determined in advance by the experimenter). After a subject cleans the face with facial cleanser of the same brand before experiment, the traditional Chinese medicine extract B obtained in the experimental example 2 is uniformly smeared on the cleaned pox part once a day in the morning and at the evening for a week. The tested part is observed before the sample is tried, on the first day of the trial, on the third day of the trial and after one week of the trial, and the number of people with different degrees of inflamed pox is recorded.
| Trial effect | Before trial | Trial day one | Trial for the third day | One week on trial |
| Severe red swelling and stabbing pain | 70 | 37 | 23 | 3 |
| Red and swollen without tingling | 0 | 18 | 15 | 2 |
| Slight red swelling without stabbing pain | 0 | 10 | 16 | 2 |
| Disappearance of red swelling | 0 | 5 | 16 | 63 |
The comprehensive experiment result shows that after one week of trial, the cure rate of the pox (the pox is from severe red swelling and stabbing pain is recovered to red swelling and disappears) is about 90 percent, so that the traditional Chinese medicine extract B has a good acne removing effect.
3. And (3) verification test III:
test subjects, 70, were enrolled and all subjects were asked to have a distinct inflamed pox in the same location on the cheek (determined in advance by the experimenter). After a subject cleans the face with facial cleanser of the same brand before experiment, the traditional Chinese medicine extract C obtained in the experimental example 3 is uniformly smeared on the cleaned pox part once a day in the morning and at the evening for a week. The tested part is observed before the sample is tried, on the first day of the trial, on the third day of the trial and after one week of the trial, and the number of people with different degrees of inflamed pox is recorded.
| Trial effect | Before trial | Trial day one | Trial for the third day | One week on trial |
| Severe red swelling and stabbing pain | 70 | 41 | 30 | 1 |
| Red and swollen without tingling | 0 | 20 | 17 | 1 |
| Slight red swelling without stabbing pain | 0 | 6 | 23 | 3 |
| Disappearance of red swelling | 0 | 3 | 10 | 65 |
The comprehensive experiment result shows that after one week of trial, the cure rate of the pox (the pox is from severe red swelling and stabbing pain is recovered to red swelling and disappears) is about 92.9 percent, so that the traditional Chinese medicine extract C has a good acne removing effect.
4. And (4) verification test four:
test subjects, 70, were enrolled and all subjects were asked to have a distinct inflamed pox in the same location on the cheek (determined in advance by the experimenter). After a subject cleans the face with facial cleanser of the same brand before experiment, the traditional Chinese medicine extract D obtained in the experimental example 4 is uniformly smeared on the cleaned pox part once a day in the morning and at the evening for a week. The tested part is observed before the sample is tried, on the first day of the trial, on the third day of the trial and after one week of the trial, and the number of people with different degrees of inflamed pox is recorded.
| Trial effect | Before trial | Trial day one | Trial for the third day | One week on trial |
| Severe red swelling and stabbing pain | 70 | 39 | 31 | 1 |
| Red and swollen without tingling | 0 | 22 | 13 | 2 |
| Slight red swelling without stabbing pain | 0 | 3 | 10 | 1 |
| Disappearance of red swelling | 0 | 6 | 16 | 66 |
The comprehensive experiment result shows that after one week of trial, the cure rate of the pox (the pox is from severe red swelling and stabbing pain is recovered to red swelling and disappears) is about 94.3 percent, so that the traditional Chinese medicine extract D has a good acne removing effect.
The deep eutectic solvent is a low-temperature eutectic mixture formed by combining a hydrogen bond acceptor (such as quaternary ammonium salt) and a hydrogen bond donor (such as carboxylic acid, polyalcohol and phenolic compound) in a certain stoichiometric ratio. The preparation process of the deep eutectic solvent is simple to operate, and the raw materials are mixed according to a certain molar ratio at normal pressure and low temperature (30-80 ℃) generally and stirred to obtain transparent and uniform liquid. The deep eutectic solvent also has the advantages of easily available materials, low price, no toxicity and easy degradation. Compared with the traditional extraction solvent, the deep eutectic solvent has higher extraction rate, and can simultaneously extract water-soluble and oil-soluble components. Therefore, the deep eutectic solvent is used for extracting the traditional Chinese medicine with complex components, which is more beneficial to obtaining the active components of the traditional Chinese medicine.
The application has the following beneficial effects:
(1) the active ingredients of red sage root are mainly divided into two categories of fat-soluble and water-soluble. Wherein the fat-soluble component comprises phenanthrenequinone derivatives such as tanshinone; the water soluble components include protocatechualdehyde and danshensu. Wherein the fat-soluble tanshinone has antibacterial and antiinflammatory effects; the water-soluble salvianolic acid can resist oxidation and protect cells.
(2) The chemical components of the sophora flavescens mainly comprise two main classes of alkaloids and flavones, wherein the alkaloid compounds can obviously increase the secretion of IFN-gamma of HaCaT cells stimulated by substance P. Has effects of eliminating dampness and relieving itching; prenylation of flavonoids can enhance their antibacterial activity.
(3) The coptis contains various isoquinoline alkaloids, the content of berberine is the highest and is 5% -8%, and the coptis further contains coptisine, methyl coptisine, epiberberine, magnoflorine and the like, and the components enable the coptis to have obvious antibacterial and anti-inflammatory effects.
(4) Centella asiatica contains various triterpenes, and its main ingredients are asiaticoside and madecassoside. The skin-care product has the effects of tightening the connecting part of the epidermis and the dermis, softening the skin, promoting the formation of collagen in the dermis and tightening the skin.
(5) Andrographis paniculata Nees contain mainly diterpene lactones, wherein andrographolide is used as the substance basis of the main pharmacological activity of Andrographis paniculata Nees. The andrographolide components have effect in inhibiting Diplococcus pneumoniae, inhibiting capillary permeability increase due to inflammation, and improving exudation and edema.
(6) The traditional Chinese medicine extract composition with the acne removing effect is obtained by extracting the traditional Chinese medicines through a deep eutectic solvent, and can achieve multiple ways of antibiosis and antiphlogosis and relieve acne symptoms. The product is green and efficient, and does not contain hormones, so that irritation and sensitization of chemical preparations to skin are avoided.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents and improvements made within the spirit and principle of the present invention are intended to be included within the scope of the present invention.
Claims (6)
1. A preparation method of a traditional Chinese medicine extract composition with an acne removing effect is characterized by comprising the following steps:
s1, mixing the raw materials according to a molar ratio of 3: 4: 1: 2, respectively weighing betaine, glycerol, 1, 3-butanediol and hexanediol, stirring at 50 ℃ until the mixture is colorless and transparent to obtain a deep eutectic solvent, and adding a certain amount of water to prepare a deep eutectic solvent aqueous solution;
s2, weighing the salvia miltiorrhiza, the sophora flavescens, the coptis chinensis, the centella asiatica and the andrographis paniculata, wherein the contents of the medicinal materials are as follows according to the dry weight percentage of the medicinal materials: 1-30% of salvia miltiorrhiza, 1-30% of radix sophorae flavescentis, 1-30% of coptis chinensis, 1-30% of centella asiatica and 1-30% of andrographis paniculata; soaking the dry powder of the traditional Chinese medicine composition in the deep eutectic solvent aqueous solution obtained in the step S1 to obtain a mixed solution;
s3, purifying the mixed solution by using macroporous adsorption resin, and collecting eluent after elution;
s4, concentrating the eluent, adding 1, 3-butanediol, stirring uniformly, standing for 24 hours, and collecting the supernatant;
s5, centrifuging the supernatant to obtain a centrifugal supernatant, wherein the centrifugal supernatant contains the traditional Chinese medicine extract composition with the acne removing effect.
2. The preparation method of the traditional Chinese medicine extract composition with the acne removing effect according to claim 1, wherein the step S2 specifically comprises the following steps:
s21, weighing 1-30 parts of salvia miltiorrhiza, 1-30 parts of radix sophorae flavescentis, 1-30 parts of coptis chinensis, 1-30 parts of centella asiatica and 1-30 parts of common andrographis herb by taking grams as a unit, and weighing the total weight of all the weighed medicinal materials as a numerical value A;
s22, recording the volume of the deep eutectic solvent aqueous solution as a numerical value B in milliliters, wherein the volume ratio of the deep eutectic solvent aqueous solution is 10-95%;
s23, measuring a certain amount of deep eutectic solvent water solution to enable the value B to be 5-20 times of the value A;
s24, soaking and extracting the measured medicinal materials in a deep eutectic aqueous solvent for 2-48 hours each time for 1-3 times, and combining the mixed extracting solutions.
3. The method for preparing a herbal extract composition with acne removing efficacy according to claim 1, wherein in step S3, the eluent used for elution is 1, 3-butanediol aqueous solution, and the volume ratio of the 1, 3-butanediol aqueous solution is 5% -95%.
4. The preparation method of the traditional Chinese medicine extract composition with the acne removing effect according to claim 1, wherein the step S4 specifically comprises:
concentrating the eluate by 3-20 times, adding 1, 3-butanediol of 1-3 times of the volume of the eluate, stirring, standing for 24 hr, and collecting supernatant.
5. The method for preparing the traditional Chinese medicine extract composition with the acne removing effect according to claim 1, wherein in step S5, the centrifugation speed is 5000r/min to 10000r/min, and the centrifugation time is 5 to 10 minutes.
6. A traditional Chinese medicine extract composition with acne removing effect is characterized in that the composition is prepared by the preparation method of any one of claims 1-5.
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