KR20010026175A - whitening composition including the natural plant extract - Google Patents

Abstract

PURPOSE: A whitening composition containing plant extract is provided, which decreases pigmentary deposits of human safely, and shows synergic effect when mixed with other common whitening materials. CONSTITUTION: A process for the preparation of each plant extract is comprised of: chopping each plant(Commiphora myrrha Engler, Psoraleae Semen, Evodiae Fructus, Meliae Fructus, seed of Leonuri Herba, seed of Angelica acutiloba), and adding 95% hydrated alcohol to each plant eatrct; boiling at 5 0-100deg.C for 10 hours by operating cooling condenser(to prevent evaporation of effective ingredients) to extract active ingredients; filtering each extract, concentrating under decompression, drying to get each plant extract. A nutritional cosmetic water containing plant extract is comprised of bees wax, polysorbate 60, sorbitansesquiolate, liquid paraffin, squalene, more than one of plant extract, glycerin, butylene glycol, propylene glycol, carboxyvinyl polymer, triethanolamine, preservatives, perfume and distilled water.

Description

Whitening composition including the natural plant extract

The present invention relates to a composition excellent in skin whitening effect, more specifically whitening, characterized in that at least one or more extracts from the group consisting of myrrh, pagoji, Osuyu, cheonnyeonja, motherwort seed, extracts of Il-Dang-Gui as an active ingredient It relates to a composition for.

Many factors are involved in determining the skin color of humans, including the activity of melanocytes that make melanin, the distribution of blood vessels, the thickness of skin and the presence or absence of pigments in the body, such as carotenoids and bilirubin. It is important. In particular, the most important factor is a black pigment called melanin produced by the action of various enzymes such as tyrosinase in melanocytes in the human body. Genetic factors, physiological factors related to hormone secretion, stress, and the like, and environmental factors such as ultraviolet ray irradiation have an influence on the formation of this melanin pigment.

In particular, ascorbic acid, kojic acid, arbutin, hydroquinone, glutathione, or the like to treat or alleviate excessive melanin pigmentation caused by abnormal symptoms of skin pigmentation such as blemishes, freckles, pigmentation, and UV exposure. These derivatives and substances with tyrosinase inhibitory activity have been used in cosmetics and pharmaceuticals, but their use is limited due to insufficient whitening effects, safety problems for skin, formulation and stability problems when formulated in cosmetics, etc. It is becoming.

Meanwhile, in addition to these existing whitening efficacy substances, research is being conducted to find whitening active ingredients in natural products. Among them, Sangbaekpi (Japanese Patent Publication No. 55-44375, So64-26507, So64-83009, Pyeong1- 1) 25687, Hei 5-139950, Korean Laid-Open Patent Nos. 92-002109, 97-021273), Licorice (Japanese Laid-Open Patent Publication No. 60-214721, Small 63-23809, Small 64-63506, Flat 1-49706, Korean Publication Patent Nos. 92-002109, 97-025601) and many plant extracts have been found to act on tyrosinase to inhibit melanin production, but they also have cosmetics in terms of safety, stability, and discoloration. There are many problems in using the drug at an effective concentration or higher, and it does not produce a satisfactory effect.

On the other hand, conventionally, a substance that inhibits melanogenesis was searched by searching for a whitening substance as an inhibitory activity against tyrosinase derived from mushrooms. However, since tyrosinase derived from mushrooms is significantly different in structure from tyrosinase, which is responsible for the synthesis of human melanin, the search by mushroom-derived tyrosinase zero shows satisfactory effects in humans. Hard to find whitening material

Therefore, the inventors of the present invention have tried to find a plant extract that can exert a whitening effect even at low concentrations in view of the fact that a natural extract cannot be used at a high concentration in terms of stability of the product, and also, in order to search for a melanogenesis inhibitor that is effective for humans, In order to overcome the problems of the conventional method using a mushroom-derived tyrosinase, a method for measuring the inhibition of melanin biosynthesis at the cellular level, which is an improved method, called Mel-Ab assay, was introduced.

The present invention relates to a composition excellent in skin whitening effect, more specifically whitening, characterized in that at least one or more extracts from the group consisting of myrrh, pagoji, Osuyu, cheonnyeonja, motherwort seed, extracts of Il-Dang-Gui as an active ingredient It relates to a composition for.

First, in order to search for melanogenesis inhibitors that are effective in humans, the whitening effect of various plant extracts was searched using melanocytes (Mel-Ab) derived from mice, which may be similar to human melanocytes.

As a result, it was found that extracts of myrrh, pagoji, sesame oil, cheonnyeonja, motherwort seed, and ildonggwi seed not only act as very good melanin inhibitors at low concentrations, but also have a clear whitening effect when applied directly to human skin. This completes the present invention (see Experiments 1 and 2).

Therefore, the present invention is to provide a composition characterized in that at least one or more extracts from the group consisting of myrrh, pagoji, sorghum, cheonnyeonja, motherwort seed, ildangwi seed extract in order to exhibit skin whitening effect as an active ingredient. .

Hereinafter, the composition for whitening centering on the technical content of this invention which can achieve the said objective is demonstrated.

Myrrh, the herbal material used in the present invention, is a fragrant medicinal tree which is hardened by spontaneous scarring or spontaneously flowing down the trunk of a myrrh tree (Commiphora myrrha, C. molmol). It is also used as astringent, puncture, and dry matter.

Pagoji is a seed of Psoralea corylifolia, which is said to help renal and reproductive functions in Chinese medicine, to treat Baekjeok for external use, and to strengthen bones.

Fructus is an immature fruit of the Echodia officinalis (E. rutaecarpa), which is used to treat vomiting, headaches, stomatitis, and toothache by warming the stomach, relieving pain, and regulating the circulation of the stomach. do.

The medicinal herb is a fruit of Melia azedarach or M. toosendan, and has been used as a medicine for long-term use as a medicine and pain medicine in traditional medicine.

Motherwort seed is a seed of the motherwort plant, Leonurus sibiricus. On the other hand, motherwort is used to help blood circulation in herbal medicine, postnatal prenatal protection, diuresis, indigestion, etc. and for wound healing, but the seed was not used for medicinal purposes. In the case of seeds, the essential oil component is contained in a large amount.

One-danged seed is the seed of the Angelica acutiloba, a flowering plant. On the other hand, Dangdang is used as a blood, tonic, analgesic, sedative in herbal medicine, but its seed was not used for medicinal purposes. In the case of seeds, the essential oil component is contained in a large amount.

Such natural plants were not previously known to have a whitening effect, and furthermore, there was no example where the extract of the natural plant was applied for the whitening effect. In particular, although patents relating to whitening efficacy have been reported for motherwort and single-ear, no application has yet been applied for the whitening effect on the seed, seed. As a ratio, through the present invention, it has been found that the extracts of such natural plants have a whitening effect even at low concentrations.

As a natural plant used in the present invention, the herbal medicine does not limit the term herbal medicine itself, and the "extract" of each natural plant is obtained by partially or completely condensing the leaching liquid obtained by leaching or transferring from the herbal medicine, or again. Concentrates, or acupuncture, premises, regular, flow extracts (hereinafter referred to as "extract extract") prepared by drying the concentrates again, and the chemicals themselves exhibiting the main effect contained in the herbal medicine.

As a natural plant extraction method of the present invention, it is possible to use a known method. For example, the natural plant according to the present invention may be dried and chopped by any method such as natural drying or forced drying, followed by polar solvents such as water, ethanol, butanol and acetone; Nonpolar solvents such as ether, hexane, benzene, chloroform and ethyl acetate; A mixed solvent of the polar solvent and the nonpolar solvent; Using a solvent such as alkaline water, or vegetable oils such as soybean oil and sesame oil, the leaching treatment is carried out by any method such as cold sedimentation, percolation, and warm sedimentation to obtain a leaching substance containing the active ingredient. The leaching treatment is about 12 to 96 hours for cold acupuncture and percolation, and depending on the type and temperature of the solvent used for warm needles, but suitably about 0.5 to 24 hours at a temperature close to the reflux temperature of the solvent. Good to do. In particular, the extracts of the present invention is preferably used tincture, liquid extract or extract of the leaching in the hydrous alcohol.

On the other hand, the amount of the natural plant extract according to the present invention is preferably 0.01 to 10.0% by weight when used in the cosmetic composition. It is because the effect cannot be expected in 0.01 weight% or less, and in 10.0 weight% or more, it is difficult in safety or preparation of a formulation form.

In addition, the composition for whitening according to the present invention may also contain other whitening ingredients, etc., which may give a synergistic effect to the main effect, in addition to the above-mentioned extracts within the range of not impairing the main effect of the present invention. It's okay. Examples of such components include kojic acid, arbutin, ascorbic acid derivatives, licorice extract, and the like.

Natural plant extract according to the present invention is suitable to apply the ethanol dilution of the leaching solution or leaching solution as a whitening cosmetic formulation as it is, but conventional herbal preparations, acupuncture, premise, tin, extract, fluid extract, syrup, ointment, It can also be used as an internal or external preparation such as a cream preparation. Such formulations may contain skin absorption promoting substances to increase the whitening effect. In addition, the dosage of these preparations varies depending on the subject's age, symptoms, and method of administration, but in the case of external preparations, 1.0 to 3.0 ml per day is preferably applied 1 to 5 times a day and continued for 1 month or more.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated more concretely based on the Example of this invention. However, it should be noted that the present invention is not limited to these examples.

[Example 1; Preparation of Myrrh Extracts]

Cut 50 g of myrrh and add 100 ml of 95% hydrous alcohol to dry weight. Cooling capacitor was installed to prevent evaporation of the active ingredient in a state of heating for 10 hours to 50 ~ 100 ℃ to extract the active ingredient, filtered and concentrated under reduced pressure completely to obtain 4.5g myrrh extract. The prepared myrrh extract has the form of a viscous red liquid paste and has a unique odor.

[Example 2; Preparation of Pagoji Extract]

Cut 50 g of phage and add 100 ml of 95% hydrous alcohol to dry weight. A cooling capacitor was installed to prevent evaporation of the active ingredient, and then heated to 50-100 ° C. for 10 hours to extract the active ingredient, filtered, concentrated under reduced pressure, and dried to obtain 3.7 g of pagoji extract. Pagoji extract prepared in the form of a viscous brown liquid paste, has a unique odor.

[Example 3; Preparation of Sewage Extract]

Cut 50 g of sewage oil and add 100 ml of 95% hydrous alcohol to dry weight. A cooling capacitor was installed to prevent evaporation of the active ingredient, and then heated to 50-100 ° C. for 10 hours to extract the active ingredient, filtered, and concentrated under reduced pressure to obtain 6.3 g of effluent oil. The prepared sewage oil extract has the form of a viscous red liquid paste and has a unique odor.

[Example 4; Preparation of Stylus Extract]

Cut 50 g of puncturer and add 100 ml of 95% hydrous alcohol to dry weight. A cooling capacitor was installed to prevent evaporation of the active ingredient, and heated to 50 to 100 ° C. for 10 hours to extract the active ingredient, filter it, and concentrated under reduced pressure to dry it to obtain 2.1 g of Stylus extract. The prepared lotus leaf extract has the form of a viscous brown liquid paste and has a unique odor.

[Example 5; Preparation of Motherwort Seed Extract]

10 g of motherwort seed is added to 100 ml of 95% hydrous alcohol by dry weight. A cooling capacitor was installed to prevent evaporation of the active ingredient, and then heated to 50 to 100 ° C. for 10 hours to extract the active ingredient, filtered, concentrated under reduced pressure, and dried to obtain 0.25 g of motherwort seed extract. The motherwort seed extract prepared is in the form of a viscous dark brown liquid paste and has a unique odor.

[Example 6; Preparation of Il-Dang-Gui Seed Extract]

10 g of Angelica gigas seeds are added to 100 ml of 95% hydrous alcohol by dry weight. A cooling capacitor was installed to prevent evaporation of the active ingredient, and then heated to 50 to 100 ° C. for 10 hours to extract and filter the active ingredient, concentrated under reduced pressure, and dried to obtain 0.3 g of myrrh. The manufactured monodonis seed extract has the form of a viscous brown liquid paste and has a unique odor.

<Experiment 1; Whitening Screening of Natural Plant Extracts>

Rat pigment cells derived from C57BL / 6 mice were placed in Dulbeccos modified Eagles media (DMEM) with 10% PBS (fetal bovine serum), 10 nM 12-O-tetradecanoylphorball-13-. Incubated at 37 ° C. and 5% CO 2 in medium containing acetate (12-O-tetradecanoylphorbol-13-acetate) and 1 nM cholera toxin. After culturing the cells at a concentration of 105 cells / well in 24 well plates and confirming cell adhesion, the test materials extracted through Examples 1 to 6 were added to the cell culture solution as shown in Table 1 to obtain a final concentration. Incubated for 3 days at 0.001% to 0.004%. The culture solution was removed, washed with PBS, and the cells were dissolved with 1N NaOH and absorbance was measured at 400 nm. Using the cells without the test substance as a control, the whitening effect was measured by measuring the degree of inhibition of melanin production of the test substance compared to the melanin content in the control.

In addition, as a comparative example, lettuce extract (Comparative Example 1), licorice extract (Comparative Example 2), motherwort extract (Comparative Example 3), monosaccharide extract (Comparative Example 4), and koji acid (extracted in the same manner as in Example 1) In Comparative Example 5), the whitening effect was measured in the same manner using C57BL / 6 mouse pigment cells.

The results obtained therefrom are shown in Table 1.

Inhibitory Effect of Plant Extracts on Melanin Production Test substance Concentration Melanin production inhibition rate (%) ^* Example 1 (myrrh extract) 0.001 52.7 Example 2 (pagoji extract) 0.001 58.9 Example 3 (Oil Extract) 0.001 54.2 Example 4 (Tianranea Extract) 0.001 52.5 Example 5 (Battleweed Seed Extract) 0.001 68.2 Example 6 (Dangdang ear seed extract) 0.001 53.3 Example 1 + Example 2 2 × 0.001 72.2 Example 1 + Example 3 2 × 0.001 70.2 Example 1 + Example 2 + Example 3 3 × 0.001 80.5 Example 1 + Example 2 + Example 4 + Comparative Example 2 4 × 0.001 92.1 Example 5 + Comparative Example 3 2 × 0.001 75.5 Example 6 + Comparative Example 4 2 × 0.001 78.3 Comparative Example 1 (Leave extract) 0.001 30.1 Comparative Example 2 (Liquorice Extract) 0.001 3.2 Comparative Example 3 (Battleweed Extract) 0.001 5.8 Comparative Example 4 (daily Angelica extract) 0.001 4.9 Fertilizer example 5 (Mt. Koji) 0.001 2.0

* Melanin production inhibition rate (%) = 100- (absorbance of each extract / absorbance of control × 100)

As shown in Table 1, the extracts of myrrh, pagoji, sesame oil, cheonnyeonja, motherwort seed, and perilla seed showed very high melanin production inhibitory effect at low concentration of 0.001% (Examples 1 to 6). In addition, these extracts were superior in effect at low concentrations compared to kojic acid, which is already known to have excellent whitening effect. In particular, the motherwort seed extract and Il Dang hui seed extract (Examples 5 and 6) were relatively superior in whitening effect compared to motherwort extract and daily Angelica extract (Comparative Examples 3 and 4) known to have a whitening effect. In addition, when the natural plant extracts according to the present invention and known extracts were selectively added, a whitening effect was obtained.

Example 7 Preparation of Nutritious Cosmetic Water Containing Myrrh Extract

Prescription examples of nutrient cosmetics containing myrrh extract are shown in Table 2.

ingredient Parts by weight Example 1 wax polysorbate 60 sorbitan sesquiolade fluid paraffin squalan caprylic / capric triglyceride glycerin butylene glycol propylene glycol carboxyvinyl polymer triethanol amine preservative pigment perfume 0.54.01.50.55.05.05.03.03.03.00.10.2trace microbalance system 100.0

Example 8 Preparation of Nutritious Cosmetic Water Containing Pagoji Extract

Prepared in the same manner as in Example 7, except for replacing the extract of Example 1 with pagoji extract of Example 2 to prepare a nutrient cosmetic.

Example 9 Preparation of Nutritious Cosmetic Water Containing Sewage Extract

Prepared in the same manner as in Example 7, except for replacing the extract of Example 1 with sewage extract of Example 3 to prepare a nutrient lotion.

Example 10 Preparation of Nutritious Cosmetic Water Containing Cheonnyeonja Extract

Prepared in the same manner as in Example 7, except for replacing the extract of Example 1 with the extract of Example 4 to prepare a nutrient lotion.

Example 11 Preparation of Nutritious Cosmetic Water Containing Motherwort Seed Extract

Prepared by the same method as in Example 7, except that the extract of Example 1 with the motherwort seed extract of Example 5 was prepared nutrient cosmetics.

Example 12 Preparation of Nutritious Cosmetic Water Containing Ildangguig Seed Extract

Prepared by the same prescription method as in Example 7, replacing the extract of Example 1 with the extract of Example 1, Dangdangguiseum to prepare nutrient cosmetics.

[Example 13: Preparation of nutritious cosmetic water containing myrrh extract and pagoji extract]

Prepared in the same manner as in Example 7, except that the extract of Example 1 was mixed and replaced by 0.5 each of the myrrh extract of Example 1 and pagoji extract of Example 2 to prepare a nutrient lotion.

Example 14 Preparation of Nutritious Cosmetic Water Containing Myrrh Extract, Pagoji Extract, and Sewage Extract

Prepared in the same manner as in Example 7, except that the extract of Example 1 was mixed and replaced by 0.5 each of the myrrh extract of Example 1, pagoji extract of Example 2 and sewage oil extract of Example 3 and replaced by nutrient cosmetics .

Example 15 Preparation of Nutrients Extract containing Myrrh Extract, Pagoji Extract, Lilium Extract, and Licorice Extract Known

Prepared in the same manner as in Example 7, except that the extract of Example 1 was mixed and replaced by 0.5 each of the myrrh extract of Example 1, the pagoji extract of Example 2, the puncture extract of Lichen and licorice extract of Example 4, respectively; Nutrients were prepared.

[Example 16: Preparation of nutritious cosmetic water containing motherwort seed extract and motherwort extract]

Prepared in the same manner as in Example 7, except that the extract of Example 1 was mixed and replaced by 0.5 each of the motherwort seed extract and known motherwort extract of Example 5, respectively, to prepare nutrient cosmetics.

[Example 17: Preparation of Nutrients Cosmetics Containing Ildangguig Seed Extract and Ildangugup Extract]

Prepared in the same manner as in Example 7, except that the extract of Example 1 was mixed and replaced by 0.5 mg each of the extract of Example 6 and the known daily Angelica extract to prepare nutritional cosmetics.

Comparative Example 6: Preparation of Nutritious Cosmetic Water Containing Kojisan

Prepared in the same manner as in Example 7, except for replacing the extract of Example 1 with kojic acid of Comparative Example 5 to prepare a nutrient cosmetic.

<Experiment 2; Whitening Effect Test on Human Body of Prescription Formulation Containing Natural Extracts ＞

Using 20 healthy men and women as test subjects, opaque tape with 6 holes of 1.5cm in diameter was attached to the lower forearm of both arms and irradiated with ultraviolet rays (UVB) of 1.5 ~ 2 times the minimum erythema of each subject. After induction of blackening, nutritional longevity containing the test substances (Examples 7 to 17 and Comparative Example 6) was corrected twice a day (morning and evening) for 8 weeks and 5 days a week. Two months later, the contrast of the skin was measured using a color difference meter. The control group was prepared in the same manner as in Example 7, but was tested by applying nutrient cosmetics that the natural plant extract is not added to the components.

The effect was determined by measuring the degree of black and white of the skin using a color difference meter (Minolta CR2002). L ^* a ^* b ^* color system is used to display the color. In this experiment, L ^* value (brightness) is mainly used as an index. The L ^* value was calibrated with a predetermined white board, and the measurement was performed by measuring the pigmentation portion evenly by repeating the measurement five times or more at one place. The difference in skin color (ΔL ^* ) at the time of starting application of the nutrient cosmetics containing the test substance and the completion of the application of the nutrient cosmetics after 8 weeks was determined and the effect was determined using this value.

ΔL ^* = L ^* after X days after application - L ^* values at the time of start of the coating

Whitening Effect of Natural Plant Extracts on Human Level Experimental substance Treatment concentration of extract (%) ΔL ^* Example 7 0.5 0.98 Example 8 0.5 1.53 Example 9 0.5 1.32 Example 10 0.5 1.65 Example 11 0.5 2.01 Example 12 0.5 1.11 Example 13 2 × 0.5 1.52 Example 14 3 × 0.5 2.55 Example 15 4 × 0.5 2.75 Example 16 2 × 0.5 1.97 Example 17 2 × 0.5 2.21 Comparative Example 6 (Mt. Koji) 0.5 0.95 Control - 0.93

As shown in Table 3, when using the nutrient cosmetics containing the natural plant extract according to the present invention, it was confirmed that the reduction of skin pigmentation. In addition, in the case of the formulation prepared by mixing the natural extract of the present invention and known natural extract, the whitening effect was shown to be increased. During this experiment, the subject showed no irritation by the use of nutrient-containing water containing plant extracts.

<Experiment 3: safety test, human patch test>

In order to determine the degree of skin irritation with respect to the composition according to the present invention, a skin patch test on the whitening cosmetics according to Examples 7 to 11 was performed on 15 subjects. 20 µl of each of the nutrients of Examples 7 to 11 was added to a fin chamber and patched to the upper arm of the human body for 24 hours, the skin reaction was examined within 1 hour after the patch was removed, and the next day (after 48 hours) was examined again. . The skin response was judged by the inspection criteria of Table 4, and the average response rate was calculated according to the following formula.

Test standard of human patch test Skin reaction code and score Negative-: 0 Suspicious minor erythema +/-: Mild reaction without 1 vesicle, erythema, papule +: Moderate reaction with 2 vesicles, erythema, papule, vesicle ++: 3 strong reaction, alveolar vesicle Reaction +++: 4

Average response rate (%) = [Σ (X score _{after 24 hours} of respondents) + Σ (X score _{after 48 hours of} respondents)] × 100 / (Total number of tests × maximum score x total number of subjects)

For example, the average reaction rate of Example 7 was calculated as follows.

((14 x 0 points + 1 x 1 point + 0 x 2 points + 0 x 3 points + 0 x 4 points) + (15 x 0 points + 0 x 1 point + 0 x 2) Dot + 0 x 3 points + 0 x 4 points) x 100 / (2 x 4 points x 15) = 0.83%

In addition, Example 8 to Example 17 was also calculated the average reaction rate in the same manner as described above. The results are shown in Table 5.

Human patch test results of whitening cosmetic composition Test substance Number of subjects responding after 24 hours (persons) Number of subjects responding after 48 hours (persons) Average response rate (%) - +/- + ++ +++ - +/- + ++ +++ Example 7 14 One 0 0 0 15 0 0 0 0 0.83 Example 8 15 0 0 0 0 15 0 0 0 0 0 Example 9 15 0 0 0 0 15 0 0 0 0 0 Example 10 15 0 0 0 0 15 0 0 0 0 0 Example 11 15 0 0 0 0 15 0 0 0 0 0 Example 12 15 0 0 0 0 15 0 0 0 0 0 Example 13 14 One 0 0 0 15 0 0 0 0 0.83 Example 14 14 One 0 0 0 15 0 0 0 0 0.83 Example 15 14 One 0 0 0 15 0 0 0 0 0.83 Example 16 15 0 0 0 0 15 0 0 0 0 0 Example 17 15 0 0 0 0 15 0 0 0 0 0

* Criteria for the average response rate (%) of the human patch test

Less than 1: non-irritating, less than 1 to 3: hard stimulation, less than 3 to 5: medium stimulation,

5 or higher: strong stimulus

As can be seen from Table 5, the whitening cosmetic composition according to the present invention can be said to be a safe substance to the human body because it belongs to the non-irritating range.

<Experiment 5: Stability Test>

In order to determine the degree of stability of the composition according to the present invention, the stability test for the whitening cosmetics according to Examples 7 to 17 was carried out.

Nutrients of Examples 7 to 17 were allowed to stand for 3 months in room temperature, 4 ℃ refrigerator, 37 ℃ thermostat and 45 ℃ thermostat, after 3 months, the change of each formulation was observed. According to the degree of separation of the formulation, '0' (stable), '+/-' (slightly unstable), and '+' (unstable).

Results of stability test of the whitening cosmetic composition Test substance Storage temperature (℃) Room temperature (25 ℃) 37 ℃ 45 ℃ Cold temperature (4 ℃) Example 7 0 0 0 0 Example 8 0 0 0 0 Example 9 0 0 0 0 Example 10 0 0 0 0 Example 11 0 0 0 0 Example 12 0 0 0 0 Example 13 0 0 0 0 Example 14 0 0 0 0 Example 15 0 0 +/- 0 Example 16 0 0 0 0 Example 17 0 0 0 0

As shown in Table 6, the whitening cosmetic compositions according to the present invention were stable at room temperature (25 ° C), cold (4 ° C), 37 ° C and 45 ° C.

As can be seen from the examples and experiments according to the present invention, the composition for whitening containing the natural plant extract according to the present invention is very safe when used in humans and has an excellent effect of reducing pigmentation. On the other hand, if the mixture contains natural extracts and known whitening substances according to the present invention shows a synergistic effect in terms of whitening effect. In addition, the natural plant extract according to the present invention has an effect of reducing pigmentation at a concentration that does not affect the stability of the product can be used as an effective concentration in the whitening cosmetics.

Claims (3)

Whitening composition, characterized in that at least one extract from the group consisting of myrrh, pagoji, Osuyu, cheonnyeonja, motherwort seed, ildangwi seed extract as an active ingredient The composition for whitening according to claim 1, further comprising a motherwort extract, a perilla extract or licorice extract to increase the whitening effect. The composition for whitening according to claim 1, wherein the composition is a cosmetic composition, and the extract contains 0.01 to 10.0 wt%.