CN113633565A - Oil-control acne-removing composition, skin care product, skin-care gel and preparation method of oil-control acne-removing composition - Google Patents
Oil-control acne-removing composition, skin care product, skin-care gel and preparation method of oil-control acne-removing composition Download PDFInfo
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- CN113633565A CN113633565A CN202110983764.7A CN202110983764A CN113633565A CN 113633565 A CN113633565 A CN 113633565A CN 202110983764 A CN202110983764 A CN 202110983764A CN 113633565 A CN113633565 A CN 113633565A
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- 206010000496 acne Diseases 0.000 title claims abstract description 122
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 121
- 239000000203 mixture Substances 0.000 title claims abstract description 80
- 238000002360 preparation method Methods 0.000 title abstract description 15
- 238000001879 gelation Methods 0.000 title description 2
- AIGAZQPHXLWMOJ-UHFFFAOYSA-N Tanshinone I Chemical compound C1=CC2=C(C)C=CC=C2C(C(=O)C2=O)=C1C1=C2C(C)=CO1 AIGAZQPHXLWMOJ-UHFFFAOYSA-N 0.000 claims abstract description 64
- 229930183118 Tanshinone Natural products 0.000 claims abstract description 32
- BNMGUJRJUUDLHW-HCZMHFOYSA-N Madecassoside Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O)OC[C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)[C@]12CC[C@H]([C@@H]([C@H]1C=1[C@@]([C@@]3(C[C@@H](O)[C@H]4[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]4(C)[C@H]3CC=1)C)(C)CC2)C)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O BNMGUJRJUUDLHW-HCZMHFOYSA-N 0.000 claims abstract description 31
- BNMGUJRJUUDLHW-HLUHVYOBSA-N Madecassoside Natural products C[C@@H]1CC[C@@]2(CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)C[C@@H](O)[C@H](O)[C@@](C)(CO)[C@@H]5[C@H](O)C[C@@]34C)[C@@H]2[C@H]1C)C(=O)O[C@@H]6O[C@H](CO[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@H]6O BNMGUJRJUUDLHW-HLUHVYOBSA-N 0.000 claims abstract description 31
- QCYLIQBVLZBPNK-UHFFFAOYSA-N asiaticoside A Natural products O1C(C(=O)C(C)C)=CC(C)C(C2(C(OC(C)=O)CC34C5)C)C1CC2(C)C3CCC(C1(C)C)C45CCC1OC1OCC(O)C(O)C1O QCYLIQBVLZBPNK-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229940090813 madecassoside Drugs 0.000 claims abstract description 31
- VIZXMHCBZLGUET-UHFFFAOYSA-N sodium gualenate Chemical compound CC(C)C1=CC=C(C)C2=C(S(O)(=O)=O)C=C(C)C2=C1 VIZXMHCBZLGUET-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229950002760 sodium gualenate Drugs 0.000 claims abstract description 10
- 239000000499 gel Substances 0.000 claims description 57
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 claims description 40
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 20
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/26—Optical properties
- A61K2800/262—Transparent; Translucent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an oil-control acne-removing composition, a skin care product, skin-care gel and a preparation method thereof. The oil-controlling and acne-removing composition comprises, by weight, 25-60 parts of tanshinone, 15-45 parts of sodium guaiazulene sulfonate and 10-30 parts of madecassoside. According to the oil-control acne-removing composition provided by the invention, the three components are compounded according to a specific proportion, so that the synergistic effect of the three active substances can be effectively exerted, and the activity of the three active substances can be more effectively exerted. According to the mass percentage, the skin care product and the skin care gel comprise 0.1-1.5% of the oil-controlling and acne-removing composition. The oil-control acne-removing composition is added into the skin care product and the skin care gel, so that the oil-control acne-removing composition is low in adding amount, has a relatively excellent oil-control acne-removing effect, and can effectively reduce the cost. The preparation method of the skin-care gel is simple in steps and convenient to operate, and the prepared skin-care gel is glittering and translucent, has good stability and good acne-removing effect and has the performance of safety and no stimulation to skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to an oil-control acne-removing composition, a skin-care product, a skin-care gel and a preparation method thereof
Background
Acne is also known as whelk, comedo and acne. It is mostly found in the area of face, back and chest with many sebaceous glands; the causes of the acne are mainly hyperseborrhea, sebaceous gland follicular hyperkeratosis, massive propionibacterium acnes propagation, perifollicular inflammatory reaction and the like.
Acne is a widespread sebaceous gland chronic inflammatory skin disease, even develops into a serious skin problem, affects more than 85 percent of adolescents worldwide, has wide potential hazards, and has become the eighth global pandemic. While acne has traditionally been considered a disease affecting adolescents, recent studies have shown that acne is affecting an increasing number of adults, about 50% of which are affected by 20 or over 20 years of age.
The existing acne removing products on the market have the following problems: 1. easily cause skin allergy and has great skin irritation; such as: patent CN105796424A discloses an acne-removing composition, which has excellent acne-removing effect. However, chemical components such as salicylic acid and azelaic acid are selected to achieve a good acne removing effect, and meanwhile, certain irritation is often brought to the skin. 2. Such as: the compound acne-removing traditional Chinese medicine extract disclosed in patent CN200910235809 comprises salvia miltiorrhiza, clove, scutellaria baicalensis, rheum officinale and mangnolia officinalis, and has a good clinical effect. Patent CN105012479A acne-removing composition comprises shea butter, phellodendron bark extract, black willow bark extract, purslane extract, perilla extract, centella asiatica extract and mung bean extract. In the patent, a plurality of Chinese herbal medicine plant extracts with low active matter content are selected as acne removing components, and the acne removing components are usually effective only by adding high amount, so that the formula cost is increased, and the effect is slow.
Disclosure of Invention
The invention aims to provide an oil-controlling acne-removing composition which can effectively inhibit skin grease secretion.
Meanwhile, the invention also provides a skin-care gel, and a good acne-removing effect can be realized by adding a small amount of the oil-control acne-removing composition.
In order to achieve the above object, the present invention adopts, as a first aspect thereof, the following technical solutions: the oil-control acne-removing composition is prepared from the following components in parts by weight: tanshinone: 25-60 parts; sodium guaiazulene sulfonate: 15-45 parts of a solvent; madecassoside: 10-30 parts.
In a preferred embodiment, the oil-controlling and acne-removing composition consists of the following components in parts by weight: tanshinone: 35-55 parts of a solvent; sodium guaiazulene sulfonate: 18-40 parts of a binder; madecassoside: 12-25 parts.
In a preferred embodiment, the oil-controlling and acne-removing composition comprises the following components in parts by mass: (1-2): 1.
in a preferred embodiment, the mass ratio of the tanshinone, the sodium guaiazulene sulfonate and the madecassoside is (1.5-3): (1.2-1.8): 1.
the tanshinone added in the oil-controlling acne-removing composition is a salvia miltiorrhiza root extract, is an effective component extracted from the salvia miltiorrhiza root, and has the effects of clearing away heat and toxic materials, promoting blood circulation to remove blood stasis, eliminating stagnation, resisting bacteria and diminishing inflammation and inhibiting excessive sebum secretion.
The tanshinone applied in the oil-controlling and acne-removing composition can play a role in effectively inhibiting propionibacterium acnes and staphylococcus aureus. Tanshinone can also inhibit the activity of 5 a-reductase, and a plurality of researches show that the 5 a-reductase can promote the secretion of skin grease. Therefore, the tanshinone applied in the composition for controlling oil and removing acne can balance grease secretion and avoid excessive exuberance of sebaceous glands.
The guaiazulene sodium sulfonate has the effects of resisting bacteria, diminishing inflammation, removing toxins, relieving pain and reducing swelling.
The madecassoside is a potent and highly pure active ingredient and is one of the main substances present in centella asiatica. It has antipruritic, anti-erythema and anti-desquamation effects, and can relieve sensitive skin, atopic dermatitis and repair acne scar. The application of the madecassoside in the oil-controlling and acne-removing composition can play a role in relieving sensitive skin, atopic dermatitis and repairing acne marks and scars.
The oil-control acne-removing composition comprises the following components in parts by mass: (1-2): 1, preferably (1.5-3): (1.2-1.8): 1. when the mass ratio of tanshinone, guaiazulene sodium sulfonate and madecassoside is (1-4): (1-2): 1, the three active substances can achieve better synergistic effect and oil control and acne removal effects after being compounded.
According to the oil-control acne-removing composition, the addition amount of tanshinone is 25-60 parts, and the addition amount of sodium guaiazulene sulfonate is 15-45 parts; the addition amount of the madecassoside is 10-30 parts, and the total weight of the three is 100 parts.
When the weight of the oil-controlling acne-removing composition is 100 parts, the tanshinone can provide excellent bacteriostatic and oil secretion balancing performances when the tanshinone addition amount is in the range of 25-60 parts. When the addition amount of the tanshinone is less than 25 parts, excellent bacteriostatic and grease secretion balancing performances cannot be obtained; when the addition amount of tanshinone is more than 60 parts, the excessive tanshinone can not exert better effect. Preferably 35-55 parts of tanshinone, and more preferably 50 parts.
The oil-control acne-removing composition is prepared from, by weight, 100 parts of the oil-control acne-removing composition, 15-45 parts of sodium guaiazulene sulfonate, preferably 18-40 parts of sodium guaiazulene sulfonate, and more preferably 30 parts of sodium guaiazulene sulfonate. When the addition amount of the guaiazulene sodium sulfonate is within the range of 15-45 parts, the guaiazulene sodium sulfonate can provide excellent effects of resisting bacteria, diminishing inflammation, removing toxins, relieving pain and diminishing swelling. When the addition amount of the guaiazulene sodium sulfonate is less than 15 parts, excellent effects of antibiosis, antiphlogosis, toxin removal, pain relief and detumescence cannot be obtained; when the addition amount of the guaiazulene sodium sulfonate is more than 45 parts, redundant guaiazulene sodium sulfonate cannot play a better effect.
The adding amount of the madecassoside is 10-30 parts, preferably 12-2 parts, and more preferably 20 parts, based on 100 parts of the oil-controlling and acne-removing composition by weight. When the addition amount of the madecassoside is within the range of 10-30 parts, the madecassoside can provide excellent effects of repairing pox scars. When the addition amount of the madecassoside is less than 10 parts, excellent effect of repairing pox scars cannot be obtained; when the addition amount of the madecassoside is more than 30 parts, the redundant madecassoside can not play a better effect.
The oil-controlling acne-removing composition disclosed by the invention can achieve better synergistic effect and oil-controlling acne-removing effect by compounding according to a specific proportion.
As a second aspect of the invention, the invention also provides a skin care product, which comprises the oil-controlling acne-removing composition in any one of the above schemes, wherein the oil-controlling acne-removing composition accounts for 0.1-1.5% of the skin care product in percentage by mass.
The skin care product can realize the effects of controlling oil and removing acnes only by adding a small amount of the oil-controlling and acne-removing composition. The corresponding skin care product also comprises other acceptable auxiliary materials on the skin care product, and the skin care product can be in a water dosage form, a jelly dosage form, an emulsion dosage form and the like.
As a third aspect of the invention, the invention also provides a skin-care gel, which comprises the following components in percentage by mass:
phase A:
phase B:
0.05 to 1 percent of arginine;
0.3 to 1 percent of phenoxyethanol;
and C phase:
arginine/lysine polypeptide 0.5-2%;
0.1-8% of D-panthenol;
0.1 to 1.5 percent of oil-controlling and acne-removing composition; wherein the oil-controlling and acne-removing composition is the oil-controlling and acne-removing composition in any one of the above schemes.
The invention provides a skin-care gel added with the oil-control acne-removing composition. The oil-controlling and acne-removing composition is added in an amount of 0.1-1.5% by mass of the skin-care gel, preferably 0.3-1% by mass of the oil-controlling and acne-removing composition, and more preferably 0.6% by mass of the skin-care gel. When the oil-control acne-removing composition is added in an amount of 0.1-1.5%, the skin-care gel has remarkable effects on removing acne, repairing acne marks and scars and inhibiting excessive secretion of skin grease. When the addition amount of the oil-controlling acne-removing composition is less than 0.1%, good oil-controlling acne-removing and acne mark scar repairing effects cannot be obtained; when the addition amount of the oil-controlling acne-removing composition is more than 1.5 percent, the effects of oil-controlling acne-removing and acne mark repairing are not obviously increased, and the cost is correspondingly improved.
As a fourth aspect of the invention, the invention also provides a preparation method of the skin-care gel, which comprises the following steps:
s1: weighing the components of the phase A, the phase B and the phase C respectively according to the proportion;
s2: mixing the components of phase A at a rotating speed of 700 r/min-900 r/min, heating to 80-85 ℃, homogenizing until the components are completely dissolved, and stirring at constant temperature for 10-15 minutes;
s3: adding the components of the phase B into the phase A after the homogeneous stirring, and quickly stirring until the components are uniformly mixed;
s4: cooling, namely adding the C-phase components when the temperature is reduced by 40-45 ℃, and stirring at the rotating speed of 700-900 r/min for 10-15 minutes until the components are completely and uniformly dispersed;
s5: filtering the discharged material by using a filter screen at the temperature of 35-37 ℃ to obtain the skin-care gel.
Wherein, the filter screen adopted for filtering and discharging is 100 meshes.
The preparation method of the skin-care gel has simple steps and convenient operation, and the prepared skin-care gel is crystal clear and has good stability.
Compared with the prior art, the invention has the following beneficial effects:
(1) the oil-controlling acne-removing composition provided by the invention is prepared by compounding tanshinone, guaiazulene sodium sulfonate and madecassoside according to a specific proportion, can effectively exert the synergistic effect of three active substances, and can more effectively exert the activity of the three active substances.
(2) The content of active substances in the oil-controlling acne-removing composition provided by the invention is up to more than 90%, and a good effect can be achieved by adding a small amount of the oil-controlling acne-removing composition in a formula, so that the utilization rate of the active substances is improved, and the formula cost and the raw material purchasing and transporting cost are greatly reduced.
(3) The oil-control acne-removing composition is added into the skin care product and the skin care gel, so that the oil-control acne-removing composition is low in adding amount, has a relatively excellent oil-control acne-removing effect, and can effectively reduce the cost.
(4) The preparation method of the skin-care gel has simple steps and convenient operation, and the prepared skin-care gel is glittering and translucent, has good stability, good acne-removing effect and safe and non-irritant performance to skin.
Detailed Description
Various exemplary embodiments, features and aspects of the invention will be described in detail below. The word "exemplary" is used exclusively herein to mean "serving as an example, embodiment, or illustration. Any embodiment described herein as "exemplary" is not necessarily to be construed as preferred or advantageous over other embodiments.
Furthermore, in the following detailed description, numerous specific details are set forth in order to provide a better understanding of the present invention. It will be understood by those skilled in the art that the present invention may be practiced without some of these specific details. In other instances, methods, means, devices and steps which are well known to those skilled in the art have not been described in detail so as not to obscure the invention.
All units used in the specification are international standard units unless otherwise stated, and numerical values and numerical ranges appearing in the present invention should be understood to include systematic errors inevitable in industrial production.
In the present specification, the meaning of "may" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In the present specification, the numerical range represented by "numerical value a to numerical value B" means a range including the end point numerical value A, B.
In the present specification, the term "water" includes any available water that can be used in the cosmetic field, such as deionized water, distilled water, ion-exchanged water, double distilled water, high purity water, and purified water.
In the present specification, if "room temperature", "normal temperature", etc. appear, the specific temperature may be 10 to 40 ℃.
Embodiments of the present invention will be described in detail below with reference to examples, but those skilled in the art will appreciate that the following examples are only illustrative of the present invention and should not be construed as limiting the scope of the present invention. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products commercially available.
A. Preparation of oil-controlling acne-removing composition
Example a 1: oil-controlling acne-removing composition I
The oil-control acne-removing composition comprises the following components in parts by weight: 50 parts of tanshinone, 30 parts of guaiazulene sodium sulfonate and 20 parts of madecassoside. Wherein the mass ratio of the tanshinone, the guaiazulene sodium sulfonate and the madecassoside is (5/2): (3/2): 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition I.
Example a 2: oil-controlling acne-removing composition II
The oil-control acne-removing composition comprises the following components in parts by weight:
60 parts of tanshinone, 25 parts of guaiazulene sodium sulfonate and 15 parts of madecassoside. Wherein the mass ratio of the tanshinone, the guaiazulene sodium sulfonate and the madecassoside is 4: (5/3): 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition II.
Example a 3: oil-controlling acne-removing composition III
The oil-control acne-removing composition comprises the following components in parts by weight: 40 parts of tanshinone, 40 parts of guaiazulene sodium sulfonate and 20 parts of madecassoside. Wherein the mass ratio of the tanshinone, the guaiazulene sodium sulfonate and the madecassoside is 2: 2: 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition III.
Comparative example a 4: oil-controlling acne-removing composition IV
The oil-controlling acne-removing composition comprises the following components in parts by weight: 50 parts of guaiazulene sodium sulfonate and 50 parts of madecassoside. Wherein the mass ratio of the tanshinone, the guaiazulene sodium sulfonate and the madecassoside is 1: 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition IV.
Comparative example a 5: oil-controlling acne-removing composition V
The oil-controlling acne-removing composition comprises the following components in parts by weight: tanshinone 60 weight portions and madecassoside 40 weight portions. Wherein the mass ratio of tanshinone to madecassoside is 1.5: 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition V. Comparative example a 6: oil-controlling acne-removing composition VI
The oil-controlling acne-removing composition comprises the following components in parts by weight: 25 parts of tanshinone, 30 parts of guaiazulene sodium sulfonate and 45 parts of madecassoside. Wherein the mass ratio of the tanshinone, the guaiazulene sodium sulfonate and the madecassoside is (5/9): (2/3): 1. and (3) uniformly mixing at room temperature to prepare the oil-controlling acne-removing composition VI.
B. Preparation of skin-care jelly
Application example B1: skin-care gel I
The embodiment provides a skin-care gel, which comprises the following components in percentage by mass:
phase A: 5% of glycerol;
2% of butanediol;
0.3% of carbomer;
60.8 percent of polyacrylate cross-linked polymer;
dipotassium glycyrrhizinate 0.1%;
1% of nicotinamide;
0.05% of sodium hyaluronate;
2% of 1, 2-pentanediol;
the balance of deionized water is 100 percent;
phase B: 0.3 percent of arginine;
0.5 percent of phenoxyethanol;
and C phase: arginine/lysine polypeptide 0.5%;
d-panthenol 3%;
the oil-controlling acne-removing composition I is 0.6 percent.
The preparation method of the skin-care gel I comprises the following steps:
s1: weighing the components of the phase A, the phase B and the phase C respectively according to the proportion;
s2: mixing the components of phase A at a rotating speed of 700 r/min-900 r/min, heating to 80-85 ℃, homogenizing until the components are completely dissolved, and stirring at constant temperature for 10-15 minutes;
s3: adding the components of the phase B into the phase A after the homogeneous stirring, and quickly stirring until the components are uniformly mixed;
s4: cooling, namely adding the C-phase components when the temperature is reduced by 40-45 ℃, and stirring at the rotating speed of 700-900 r/min for 10-15 minutes until the components are completely and uniformly dispersed;
s5: filtering the discharged material by using a 100-mesh filter screen at the temperature of 35-37 ℃ to obtain the skin-care gel I.
Application example B2: skin-care gel II
The skin-care gel provided by the application example B2 comprises 0.6% of the oil-control and acne-removing composition II prepared in the example A2 by mass percent, and the rest components and the component proportion are the same as the application example B1.
The preparation method of the skin care gel II is the same as that of application example B1.
Application example B3: skin-care gel III
The skin care gel provided by the embodiment comprises 0.6% of the oil-controlling acne-removing composition III prepared in the embodiment A3 by mass percent, and the rest components and the component proportion are the same as those in the application embodiment B1.
The preparation method of the skin care gel III is the same as that of application example B1.
Application comparative example B4: skin-care gel IV
The skin-care gel provided by the comparative example comprises 0.6% of the oil-control acne-removing composition IV prepared in the comparative example A4 by mass percent, and the rest components and the component proportion are the same as those in the application example B1.
The preparation method of the skin care gel IV is the same as that of application example B1.
Application comparative example B5: skin-care gel V
The comparative example provides a skin-care gel, which comprises 0.6% of the oil-control acne-removing composition V prepared in the comparative example A5 in percentage by mass, and the rest components and the component proportion are the same as those in the application example B1.
The skin care gel V was prepared in the same manner as in application example B1.
Application comparative example B6: skin-care gel VI
The comparative example provides a skin-care gel, which comprises 0.6% of the oil-control acne-removing composition VI prepared in the comparative example A6 in percentage by mass, and the rest components and the component proportion are the same as those in the application example B1.
The preparation method of the skin care gel VI is the same as that of application example B1.
C. Effect verification
C1: human body safety test
The skin care gels I to VI and the negative control (containing no test substance) of each group of experiments were tested for spot adhesion according to the method of the spot adhesion test on human skin in the edition of 2015, the technical Specification for cosmetic safety, and the results were recorded according to the skin reaction grading standard, with the results shown in Table 2.
TABLE 1 grading Standard of skin reaction in human trial test
TABLE 2 test results
As can be seen from the table 2, the results of the human body patch test show that the skin of 33 subjects using the skin-care gels I to VI has no adverse reaction, and the skin-care gels I to VI have good use safety for the human skin.
C2: acne treatment efficacy test
The test method comprises the following steps: acne skin test subjects aged 19 to 28 years were selected, test samples (application examples B1 to B3 and application comparative examples B4 to B6) were used 1 time each day in the morning and evening for 3 days and 7 days, and then the acne number was quantitatively measured using a Digimic2000 skin test system, and the reduction ratio of the acne number from the initial value before use was calculated, and the test data results are shown in table 3.
TABLE 3 acne removing efficacy test results
As can be seen from table 3, the results of the oil-control and acne-removal efficacy tests showed that the number of acne was reduced to different degrees after 3 days and 7 days of the test skin gel I-VI. The number of acne was greatly reduced in subjects after 3 days and 7 days of application of skin care gel I and skin care gel II. The subjects also had a greater reduction in the number of acne after 3 and 7 days of skin care gel III, but the reduction in the number of acne after 7 days was slightly less than skin care gel I, II. The number of acnes of the tested person is reduced in a lower rate after the skin-care jelly IV-VI is used.
C3: crowd probation survey
And respectively carrying out crowd trial investigation on the test products. Selecting acne skin subjects with the age of 19-28 years, using the skin-care gel I-VI of the test product for 7 days respectively 1 time in the morning and at night every day, filling in a use effect questionnaire, and counting the results according to the following conditions, wherein the counting results are shown in table 4.
And (3) healing: the skin lesion is removed, or only a few acne marks and scars are left, and the curative effect index is more than 90 percent;
the effect is shown: the skin lesions are mostly removed, and the curative effect index is 60-90%;
the method has the following advantages: the skin damage is partially faded away, and the curative effect index is 20-60%;
and (4) invalidation: the skin damage is not obviously subsided, and the curative effect index is less than 20%.
TABLE 4 statistical results of the population probation survey
From the above experimental data, the following experimental results were obtained:
as can be seen from Table 4, the results of the trial survey of the population show that the acne lesions of the subjects subside to different degrees after 7 days of the skin-care gels I to III. And 7 days after the test product skin-care gel IV-VI is used, the fading condition of the acne skin lesion is poorer than that of the skin-care gels I-III.
C4: skin surface oil content test
The oil content of the skin surface was measured by using an oil content measuring probe of a multifunctional skin tester MPA580 (CK, germany). The probe (SM815) contained a special matt tape 8mm wide and about 0.1mm thick. The principle is that the adhesive tape becomes semitransparent when absorbing grease, and the transparency is larger as the grease amount is increased. Therefore, the light transmission amount is used as the measuring basis of the oil content on the skin surface. Higher values indicate higher oil content of the skin. Table 5 shows the change in the oil content on the skin surface of the subject after 7 days of application and before application.
TABLE 5 test results of changes in the oil content on the skin surface of the subjects
| Tester number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Average |
| Before use | 58 | 63 | 36 | 53 | 29 | 76 | 16 | 98 | 37 | 49 | 51.2 |
| Skin-care gel I | 23 | 38 | 27 | 30 | 26 | 36 | 5 | 56 | 23 | 28 | 29.2 |
| Skin-care gel II | 21 | 27 | 18 | 25 | 20 | 28 | 6 | 48 | 18 | 25 | 23.6 |
| Skin-care gel III | 31 | 42 | 21 | 31 | 27 | 41 | 9 | 61 | 30 | 31 | 32.4 |
| Skin-care gel IV | 42 | 46 | 29 | 37 | 30 | 45 | 15 | 86 | 35 | 39 | 40.4 |
| Skin-care gel V | 37 | 50 | 33 | 39 | 26 | 47 | 14 | 78 | 3 | 34 | 39.5 |
| Skin-care gel VI | 39 | 43 | 30 | 33 | 26 | 44 | 16 | 65 | 35 | 43 | 37.4 |
As can be seen from Table 5, the average oil content on the skin surface of the subjects after 7 days of application of the skin care gels I to VI tended to decrease compared to that before application. And after 7 days of using the skin-care gel I-III, the average oil content on the surface of the skin is more obviously reduced compared with the skin-care gel IV-VI.
It should be understood that the above embodiments are only for illustrating the technical solutions of the present invention, and not for limiting the same, and those skilled in the art may modify the technical solutions described in the above embodiments, or make equivalent substitutions for some technical features; and all such modifications and alterations are intended to fall within the scope of the appended claims.
Claims (7)
1. The oil-controlling acne-removing composition is characterized by comprising the following components in parts by weight: tanshinone: 25-60 parts; sodium guaiazulene sulfonate: 15-45 parts of a solvent; madecassoside: 10-30 parts.
2. The oil-controlling acne-removing composition according to claim 1, which comprises the following components in parts by weight: tanshinone: 35-55 parts of a solvent; sodium guaiazulene sulfonate: 18-40 parts of a binder; madecassoside: 12-25 parts.
3. The composition for controlling oil and removing acne according to claim 1, wherein the mass ratio of tanshinone, guaiazulene sodium sulfonate and madecassoside is (1-4): (1-2): 1.
4. the composition for controlling oil and removing acne according to claim 3, wherein the mass ratio of tanshinone, guaiazulene sodium sulfonate and madecassoside is (1.5-3): (1.2-1.8): 1.
5. a skin care product is characterized by comprising the oil-controlling and acne-removing composition as defined in any one of claims 1 to 4, wherein the oil-controlling and acne-removing composition accounts for 0.1 to 1.5 percent of the skin care quality.
6. The skin-care gel is characterized by comprising the following components in percentage by mass:
phase A:
phase B:
0.05 to 1 percent of arginine;
0.3 to 1 percent of phenoxyethanol;
and C phase:
arginine/lysine polypeptide 0.5-2%;
0.1-8% of D-panthenol;
0.1 to 1.5 percent of oil-controlling and acne-removing composition;
the oil-controlling and acne-removing composition is the oil-controlling and acne-removing composition as claimed in any one of claims 1-4.
7. A method of preparing a skin care jelly according to claim 6,
the method comprises the following steps:
s1: weighing the components of the phase A, the phase B and the phase C respectively according to the proportion;
s2: mixing the components of phase A at a rotating speed of 700 r/min-900 r/min, heating to 80-85 ℃, homogenizing until the components are completely dissolved, and stirring at constant temperature for 10-15 minutes;
s3: adding the components of the phase B into the phase A after the homogeneous stirring, and quickly stirring until the components are uniformly mixed;
s4: cooling, namely adding the C-phase components when the temperature is reduced by 40-45 ℃, and stirring at the rotating speed of 700-900 r/min for 10-15 minutes until the components are completely and uniformly dispersed;
s5: filtering the discharged material by using a filter screen at the temperature of 35-37 ℃ to obtain the skin-care gel.
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