CN113749986A - Shea butter sensitive skin full-effect repair emulsion and preparation method and application thereof - Google Patents

Abstract

The invention provides a shea butter emulsion and a preparation method thereof. The emulsion comprises shea butter and a liquid crystal emulsifier. The shea butter emulsion disclosed by the invention has quick, comprehensive and obvious relieving and improving effects on skin allergy symptoms including eczema, acne, dry itching and red swelling; the shea butter emulsion can keep the skin healthy, promote the blood circulation of the skin, shrink pores, make the skin firmer, effectively repair skin barriers and prevent the skin from relapsing after being continuously used.

Description

Shea butter sensitive skin full-effect repair emulsion and preparation method and application thereof

Technical Field

The present invention relates to the field of cosmetics. In particular to a sensitive skin full-effect repairing emulsion taking shea butter as an effective component, and a preparation method and application of the emulsion.

Background

In china, nearly 80% of women have skin problems. 72% of the population consciously perceive the skin as sub-healthy, and 14% consider themselves to have significant skin disease. For the treatment of skin problems, 64% of the patients are preferably self-administered or tolerated, and 35.75% of the patients consider to see the dermatology department in time. Even 45% of college students with poor skin condition have affected mental health problems such as unconsciousness, social interaction, and job hunting.

Currently, several major symptoms of skin allergy are: eczema, acne, and red rash, pruritus, blister, and red swelling due to allergy. Wherein the acne accounts for 63%, the dry desquamation accounts for 45%, and the skin sensitivity accounts for 33%. The main current approach to treating allergic muscles is to use antibiotic and hormonal drugs, but the long-term use of these drugs can be harmful to the human body.

In fact, the major skin allergy problem is the impaired skin barrier. The skin barrier is the first line of defense of the human body, and the healthy skin barrier can resist external harmful substances, stimulation and sunlight entering and has the effects of moisturizing and regulating. However, when the skin barrier is fragile or damaged, the skin cannot adapt to the change of the external environment, so that sensitive and inflammatory reactions of the skin can be easily caused, and a lot of troubles of skin allergy can be brought.

However, no skin care product capable of fully relieving all skin allergy symptoms exists in the current skin care products.

Disclosure of Invention

The invention aims to provide a skin allergy full-effect repairing solution which is rapid, obvious in effect, plant healthy, high in cost performance and easy to popularize, so that the problem that no healthy and easily-popularized skin allergy repairing skin care product exists at present is solved.

In a first aspect, the present invention provides a shea butter emulsion comprising shea butter and a liquid crystal emulsifier, wherein the shea butter has a purity of greater than 99.9% and an acid number of < 5; the liquid crystal emulsifier comprises 2 or more than 2 of lecithin emulsifier, sucrose ester emulsifier, glucoside emulsifier, phytosterol and higher fatty alcohol.

In a preferred embodiment, the shea butter has a natural bioactive content of 5-10 wt%, and the natural bioactive substances are cinnamic acid, terpineol, episterol, natural vitamins A, E and F, and micronutrients.

In a specific embodiment, the liquid crystal emulsifier comprises lecithin emulsifiers, sucrose ester emulsifiers, glycoside emulsifiers, phytosterols and higher fatty alcohols.

In a preferred embodiment, the higher fatty alcohols are behenyl alcohol, stearyl alcohol and cetyl alcohol.

In a specific embodiment, the emulsion comprises the following ingredients in parts by weight:

2.0-6.0 parts of liquid crystal emulsifier;

6.0-35.0 parts of grease, wherein the shea butter is 6-25 parts;

2.0-6.0 parts of a humectant;

0.01-0.10 part of sodium hyaluronate;

1.0-8.0 parts of water-soluble functional components;

0.1-0.5 part of thickening agent;

0.1-1.0 part of preservative;

water is added to 100.0 parts.

In a preferred embodiment, the humectant is one or more of a natural humectant and a synthetic humectant;

the natural humectant is selected from one or more of hyaluronic acid, sorbitol, xylitol, mannitol, panthenol, sodium PCA, lactic acid, betaine, polyglutamic acid, trehalose, and aloe extract;

the synthetic humectant is one or more selected from glycerol, 1, 2-propylene glycol, diglycerol, 1, 3-propylene glycol, dipropylene glycol, 1, 3-butanediol, polyglycerol-10 and polyethylurea.

In a preferred embodiment, the thickener is selected from one or more of organic synthetic water-soluble thickeners, organic semi-synthetic water-soluble thickeners and organic natural water-soluble thickeners.

In a preferred embodiment, the organic synthetic water soluble thickener is one or more of acrylates/C10-30 alkanol acrylate crosspolymer, carbomer (Carbopol 941 (long rheology), Carbopol 934 (short flow or high viscosity), Carbopol 940 (short flow or high viscosity), Carbopol 980 (short flow or high viscosity), Carbopol 981 (long flow or low viscosity), Carbopol Ultrez 10 (short flow or high viscosity), Carbopol Ultrez 30 (medium short flow or high viscosity)), polyethylene glycol-n, PEG-150 distearate, acrylic acid copolymer, sodium polyacrylate, polyacrylate crosspolymer-6;

the organic semi-synthetic water-soluble thickener is one or more of hydroxypropyl methylcellulose, hydroxyethyl cellulose, sodium carboxymethylcellulose and PEG-120 methyl glucose dioleate;

the organic natural water soluble thickener is one or more of sclerotium rolfsii gum, xanthan gum, carrageenan, guar gum, pectin, starch, sodium alginate, carrageenin and gellan gum.

In a specific embodiment, the water-soluble functional component is one or more selected from allantoin, chamomile essence, astragaloside, purslane, bisabolol, scutellaria baicalensis, paeoniflorin, bamboo leaf flavone, witch hazel, olive leaf extract, OPC gludolan, dipotassium glycyrrhizinate, sea buckthorn oil and salvia miltiorrhiza root extract;

and/or

Is selected from one or more of riboflavin, baicalein, and azelaic acid.

In a preferred embodiment, the preservative is selected from one or more of aldehydes, esters, quaternary ammonium salts, acids and salts thereof, phenols, alcohol ethers, 1, 2-diols, organic acids, aromatic phenols, aromatic alcohols and plant extracts;

the aldehydes are selected from one or more of formaldehyde, bis (hydroxymethyl) imidazolidinyl urea, formaldehyde benzyl alcohol hemiacetal, DMDM hydantoin, imidazolidinyl urea and glutaraldehyde;

the esters are selected from one or more of 4-hydroxybenzoic acid esters and iodopropynyl alcohol butyl carbamate IPBC;

the quaternary ammonium salt is selected from one or more of benzalkonium chloride, cetrimide, benzethonium chloride, stearyl trimethyl ammonium chloride, chlorhexidine, behenyl trimethyl ammonium chloride and hexetidine;

the acid and its salt is selected from one or more of formic acid, sorbic acid, propionic acid, salicylic acid, benzoic acid, and dehydroacetic acid;

the phenols are selected from one or more of benzyl chlorophenol, phenyl phenol, chloroxylenol and bromochlorophene;

the alcohol ethers are selected from one or more of benzyl alcohol, phenoxyethanol, dichlorobenzyl alcohol, phenoxyisopropanol, chlorphenesin, chlorobutanol and 2-bromo-2-nitro-1, 3-propylene glycol;

the 1, 2-dihydric alcohol is selected from one or more of 1, 2-hexanediol, 1, 2-pentanediol, ethylhexyl glycerol and octyl glycol;

the organic acid is selected from one or more of p-anisic acid, ferulic acid, levulinic acid, glyceryl caprylate, lichenic acid and sorbitan caprylate;

the aromatic phenol and aromatic alcohol are selected from one or more of resina persicae phenol, thymol, and phenethyl alcohol;

the plant extract is selected from one or more of neem seed oil and tea tree essential oil.

In a preferred embodiment, if the thickening agent is a carbomer thickening agent, a sodium hydroxide solution is added into the system, wherein the ratio of the carbomer to the 10% sodium hydroxide solution is 1: 2.

In a specific embodiment, the oil is vegetable oil; besides shea butter, the oil contains one or more vegetable oils and fats selected from almond oil, lithospermum oil, pomegranate oil, chamomile oil, balm essential oil, coconut oil, palm oil, olive oil, grape seed oil, mango seed fat, camellia seed oil, sunflower seed oil, jojoba seed oil, walnut seed oil, Chinese chestnut seed oil, shea butter, evening primrose oil, avocado oil, wild soybean oil, cocoa seed fat, carnauba wax and olive oil.

In a preferred embodiment, the oil is almond oil, lithospermum oil, chamomile oil, balm essential oil, and other one or more vegetable oils.

In a second aspect, the present invention provides a cosmetic composition comprising the shea butter emulsion of the first aspect.

In a third aspect, the present invention provides a pharmaceutical composition comprising the shea butter emulsion of the first aspect and optionally a pharmaceutically acceptable carrier.

In a preferred embodiment, the pharmaceutical composition is a topical pharmaceutical composition.

In a fourth aspect, the present invention provides the use of the shea butter emulsion of the first aspect in the preparation of a cosmetic or pharmaceutical composition.

In a fifth aspect, the present invention provides a method for preparing the shea butter emulsion of the first aspect, comprising the steps of:

1) weighing a liquid crystal emulsifier and grease containing shea butter as oil phases, and preheating the oil phases;

2) weighing humectant, sodium hyaluronate, water-soluble effective component and thickener as water phase, and preheating;

3) after the oil phase is dissolved, homogenizing the water phase, and directly adding the oil phase under the homogenization condition;

4) stirring the emulsion at room temperature to reduce the temperature; adding antiseptic into the emulsion, stirring to room temperature, and packaging.

In a specific embodiment, the preparation method comprises the following steps:

1) weighing the following raw materials in parts by weight as an oil phase, and putting the oil phase into a constant-temperature water bath kettle at 70-78 ℃ for preheating;

2.0-6.0 parts of liquid crystal emulsifier;

6.0-35.0 parts of grease, wherein the shea butter is 6-25 parts;

2) weighing the following raw materials in parts by weight as a water phase, and preheating the water phase in a constant-temperature water bath kettle at 70-78 ℃;

2.0-6.0 parts of a humectant;

0.01-0.10 part of sodium hyaluronate;

1.0-8.0 parts of water-soluble functional components;

0.1-0.5 part of thickening agent;

adding water to 100.0 parts;

3) homogenizing the water phase when the oil phase is dissolved and reaches a set temperature (70-78 deg.C according to the oil phase composition), and directly adding the oil phase under the condition of homogenization (the homogenization rate is adjusted at 4000-8000rpm according to the system), and homogenizing for 5-8 min;

4) taking the emulsion out of the constant-temperature water bath kettle, and stirring and cooling at the external temperature of 25-28 ℃ and the rotation speed of 300-; when the temperature is reduced to 45-50 ℃, 0.1-1.0 part of preservative is added into the emulsion, the mixture is continuously stirred to the room temperature, and then the mixture is packaged.

In a preferred embodiment, the functional component, the operation steps of which are determined according to the nature of the functional component itself; if the effective components can stably exist at the emulsification temperature, the effective components are added into the corresponding water phase or oil phase in the preheating process; if the functional components are not resistant to high temperature, the system needs to be added in time in the stirring and cooling process.

In a sixth aspect, the present invention provides a method of treating, ameliorating or alleviating the symptoms of skin allergy, comprising administering to a subject in need thereof a shea butter emulsion according to the first aspect, or a cosmetic composition according to the second aspect, or a pharmaceutical composition according to the third aspect.

In a preferred embodiment, the subject is a mammal, preferably a human.

In a preferred embodiment, the skin allergy symptoms include, but are not limited to, eczema, acne, dry itching, redness and swelling.

It is to be understood that within the scope of the present invention, the above-described features of the present invention and those specifically described below (e.g., in the examples) may be combined with each other to form new or preferred embodiments. Not to be reiterated herein, but to the extent of space.

Drawings

Figure 1 shows the treatment results for obstinate eczema in children (6 days, 4 applications every other night);

FIG. 2 shows pox treatment case 1(5 days, 1 in the morning and evening per day);

FIG. 3 shows pox treatment case 2(5 days, 1 in the morning and evening);

fig. 4 shows pox treatment case 3(5 days, 1 in the morning and evening);

fig. 5 shows pox treatment case 4(5 days, 1 in the morning and evening); and

fig. 6 shows pox treatment case 5(9 days, 1 in the morning and evening).

Detailed Description

The inventor finds that the existing cosmetics or medicines for treating, improving or relieving skin allergy symptoms cannot simultaneously and obviously improve or treat acne, eczema and various skin allergy symptoms. Through extensive and intensive research, the inventor unexpectedly discovers that the allergic muscle full-effect repair emulsion prepared by taking specific shea butter as a main component and combining other traditional Chinese medicine herbal functional components and adopting a specific process can quickly, effectively and comprehensively relieve all skin allergic symptoms, and particularly can simultaneously play a role in acne, eczema and various skin allergic symptoms. The present invention has been completed based on this finding.

Allergic symptoms of skin

Several major symptoms of skin allergy include:

eczema is a common skin disease in modern society, and patients with eczema can be suffered from various ages and are common to infants. Eczema is a common inflammatory skin disease of epidermis and dermis superficial layer caused by various internal and external factors. Eczema has a complex pathogenesis and is mainly a delayed allergic reaction caused by complex internal and external exciting factors. The sensitivity of a patient is very strong, a lot of substances can be positively reacted during a patch test, but eczema cannot disappear quickly after the sensitizing factors are removed; some patients can change the reactivity of the organism by strengthening exercise, changing the environment and the like, and can not have eczema when receiving various factors which induce the eczema in the past, which all show the complexity of the pathogenesis of the eczema. The subjective symptoms are intense in pruritus. If acute and subacute eczema is not treated actively, the eczema can be converted into chronic eczema if the eczema is not cured repeatedly, the skin lesion is dark red or brownish red spots or maculopapules, the skin lesion is often combined and thickened to be changed like lichen, scales, scratches and blood crusts are formed on the surface of the eczema, and the eczema is scattered around a few papules, maculopapules and the like. And the disease is repeatedly developed at this time.

The current treatment method for eczema comprises the following steps: at present, no specific therapy is available for eczema dermatosis, and oral antihistamine medicines and corticoid medicines are mostly adopted for temporary inhibition. Such as oral western medicine, oral hormone, topical solution lotion, emulsion, paste, oil, ointment, emulsion, plastics, tincture and plaster.

Acne is also known as "whelk", "acne", "comedo" or "pox". The pathogenesis of the cancer is mainly recognized as four aspects: hyperkeratosis of the epithelium of hair follicles and sebaceous glands; sebaceous gland mass secretion; colonization by microorganism (Propionibacterium acnes, Malassezia); inflammation and immune response. In adolescence, a large amount of androgen is secreted, so that the proliferation and abnormal keratinization of the epifollicular sebaceous gland duct are promoted, acne is formed, and pores are blocked. The sebaceous gland secretes a large amount, and the androgen can cause the blockage of a hair follicle duct and can also secrete a large amount of sebum by stimulating the sebaceous gland. Two major microorganisms live in the follicular ducts: propionibacterium acnes and Malassezia are propagated in large quantities. The exuberant sebum secretion tends to accumulate dirt, especially fat-soluble organic substances and many kinds of microorganisms, which induce inflammation and infection. The pores are large, so that bacteria, fungi, viruses and the like can be easily driven in directly to cause infection, thereby causing inflammatory reaction, and acne generates comedones.

The current treatment method for pox comprises the following steps: acne is caused by the fact that sebaceous gland secretion is vigorous due to simple endocrine disturbance, and the symptoms caused by overhigh androgen level can be considered by using estrogen medicines, and the oil secretion is reduced so as to improve the symptoms of the acne; if the follicular orifice is large due to follicular keratosis and then the sebaceous gland duct is blocked, closed-pore pox can occur, the treatment can be carried out by using a medicament for softening the cutin, such as vitamin A acid cream or salicylic acid cream; pox presents an infectious condition that generally requires topical mupirocin cream treatment, and in severe cases oral tetracycline antibiotic treatment is also contemplated.

For sensitive skin, if allergy occurs, symptoms such as red rash, itching, blisters, red swelling, etc. may be caused. Skin allergy may be caused by exposure to allergic substances, such as food with allergic properties, or by the administration of certain drugs. At present, the symptoms of sensitive skin are relieved mainly by taking chlorpheniramine, loratadine, cetirizine and other medicaments.

Therefore, the pathogenesis of eczema and pox is completely different. Eczema is an inflammatory skin disease of epidermis and dermis superficial layer which is mostly generated due to allergy caused by internal and external factors, and is frequently generated in infants. Acne is skin inflammation caused by blockage of sebaceous gland ducts due to large follicular orifices caused by endocrine changes, and is frequently found in whelk. At present, no specific treatment is available for eczema and pox skin diseases. Hormone and antibiotic treatment are mostly used, the treatment is temporary and permanent, and long-term use has side effect on human body.

Shea butter

Shea butter (or shea butter) from Africa is mainly produced in West Fei (70% of the world's Missible oil grows in Buckinasuo in West Fei). Shea butter has a persistent vitality, and shea butter squeezed from the fruit contains rich nutrient substances.

The american shea butter association, established in 2002, classified shea butter into four levels of ABCF. The shea butter used in the present invention is a grade a shea butter, a shea butter with high purity (> 99.9%), low acid value (< 5). The shea butter used in the present invention is rich in natural bioactive substances. In a specific embodiment, the shea butter has a natural bioactive content of 5-10 wt%, and the natural bioactive substances are cinnamic acid, terpineol, episterol, natural vitamins A, E and F, and trace phytonutrients. The shea butter is rich in nutrient substances, fine and smooth and easy to absorb, and does not contain any chemical additive.

As used herein, "acid number" is meant to indicate the number of milligrams of potassium hydroxide (KOH) required to neutralize 1 gram of chemical. Acid number is a measure of the amount of free carboxylic acid groups in a compound (e.g., fatty acid) or mixture. A typical measurement procedure is to dissolve a known aliquot of the sample in an organic solvent, titrate it with a known concentration of potassium hydroxide solution, and use the phenolphthalein solution as a color indicator. The acid value can be used as an index of the degree of deterioration of the oil or fat. The unit of acid number is: (KOH)/(mg/g).

Shea butter allergic muscle full-effect repair emulsion, pharmaceutical composition and cosmetic composition

In the present invention, "shea butter allergic muscle full-effect repair emulsion", "shea butter emulsion" or "shea butter emulsion" has the same meaning. The terms refer to emulsion formed by using A-grade shea butter as a main ingredient, combining the concept of Chinese traditional medicine Chinese prescription, blending herbal functional components such as almond oil, lithospermum oil, chamomile, balm essential oil and the like into the formula and utilizing a specific liquid crystal emulsifier.

Besides shea butter, the shea butter emulsion of the invention may further contain one or more vegetable oils and fats selected from almond oil, lithospermum oil, pomegranate oil, chamomile oil, balm essential oil, coconut oil, palm oil, olive oil, grape seed oil, mango seed fat, camellia seed oil, sunflower seed oil, jojoba seed oil, walnut seed oil, Chinese chestnut seed oil, shea butter, evening primrose oil, avocado oil, wild soybean oil, cocoa seed fat, carnauba wax and olive oil.

In a preferred embodiment, the shea butter emulsion of the invention may comprise, in addition to shea butter, oils and fats such as almond oil, comfrey oil, chamomile oil, balm essential oil, and one or more other vegetable oils and fats as described.

On the basis of the shea butter emulsion of the present invention, the present invention also provides a pharmaceutical composition or a cosmetic composition comprising the shea butter emulsion. In addition to the shea butter emulsion of the invention, the pharmaceutical composition further comprises a pharmaceutically acceptable excipient; the cosmetic composition also comprises a carrier which can be used in cosmetics. Based on the efficacy possessed by the shea butter emulsion of the present invention, those skilled in the art will appreciate that the pharmaceutical or cosmetic composition is mainly formulated into a dosage form for external or topical application. Thus, the skilled person can select suitable excipients according to the desired dosage form.

Liquid crystal emulsifier

The shea butter emulsion also comprises a liquid crystal emulsifier, so that the shea butter emulsion can form lamellar liquid crystal which is similar to the structure of human skin and has extremely high skin safety on the skin. The existence of the lamellar liquid crystal can not only solubilize various functional components and obviously increase the efficacy of the emulsion, but also effectively protect water and water-soluble substances in the liquid crystal layer and oil-soluble functional components in the oil phase, improve the moisture retention of the emulsion and promote the performance of the functional components in the emulsion.

In a specific embodiment, the liquid crystal emulsifier comprises 2 or more kinds of lecithin emulsifiers, sucrose ester emulsifiers, glycoside emulsifiers, phytosterols and higher fatty alcohols. In a more preferred embodiment, the liquid crystal emulsifier comprises lecithin-based emulsifiers, sucrose ester-based emulsifiers, glycoside-based emulsifiers, phytosterols and higher fatty alcohols. Wherein the lecithin-based emulsifier includes, but is not limited to, Nikkomulse LC (NIKKOL corporation, Japan) and Prolipid (ISP corporation, USA); the sucrose ester emulsifiers include, but are not limited to, Eumulgin Suro (BASF, Germany) and Arlatone 2121(ICI Corp., USA); the glycoside emulsifiers include, but are not limited to, Montanov 68, Montanov 82, Montanov 202, Montanov L, and Montanov S (SEPPIC corporation, france); the phytosterols include, but are not limited to, PEG 30-phytosterols; the higher fatty alcohols include, but are not limited to, behenyl alcohol, stearyl alcohol, and cetyl alcohol.

The invention has the advantages that:

1. the emulsion of the invention does not add any pigment, presents the specific color of natural plant raw materials;

2. the emulsion disclosed by the invention is quick in effect, and can generate comprehensive and obvious relieving and improving effects on skin allergy symptoms such as eczema, acne, dry itching, redness and swelling within 12 hours, preferably 8-10 hours aiming at the problem of allergic skin;

3. by continuously using the emulsion disclosed by the invention, the skin can be kept healthy, the blood circulation of the skin is promoted, pores are shrunk, the skin is firmer, the skin barrier is effectively repaired, and the recurrence of skin problems is prevented;

4. the emulsion fills the blank of effectively treating skin allergy problems such as eczema, acne and sensitive skin at the same time; and

5. the emulsion of the invention adopts full plant functional components to repair and strengthen the skin barrier without any side effect on human body.

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. The experimental procedures, in which specific conditions are not noted in the following examples, are generally carried out under conventional conditions or conditions recommended by the manufacturers. Unless otherwise indicated, percentages and parts are by weight.

Example 1 preparation of Shea butter ALL-EFFECT EMULSION FOR REPAIRING MUSCLE

The formula of the shea butter allergic muscle emulsion is as follows (the parts are shown as parts by weight):

liquid crystal emulsifier 4 parts (hydrogenated lecithin, phytosterol, behenyl alcohol, stearyl alcohol, cetyl alcohol)

Shea butter 10 parts

Olive oil 5 parts

Sweet almond oil 3 parts

2 parts of chamomile oil

2 portions of bran distillate oil

Lithospermum oil 8 parts

Glycerin 4.0 parts

0.1 part of sodium hyaluronate

Carbomer 9800.15 parts

Allantoin 0.1 part

0.3 part of dipotassium glycyrrhizinate

3 portions of chamomile drug element

0.3 portion of 10 percent sodium hydroxide

100 portions of water

The preparation of the emulsion comprises the following steps:

(1) weighing the following raw materials in parts by weight as an oil phase, and putting the oil phase into a constant-temperature water bath kettle at 75 ℃ for preheating;

liquid crystal emulsifier 4 parts (hydrogenated lecithin, phytosterol, behenyl alcohol, stearyl alcohol, cetyl alcohol)

Shea butter 10 parts

Olive oil 5 parts

Sweet almond oil 3 parts

2 parts of chamomile oil

2 portions of bran distillate oil

Lithospermum oil 8 parts

(2) Weighing the following raw materials in parts by weight as a water phase, and preheating the water phase in a constant-temperature water bath kettle at 75 ℃;

glycerin 4.0 parts

0.1 part of sodium hyaluronate

Carbomer 9800.15 parts

Allantoin 0.1 part

0.3 part of dipotassium glycyrrhizinate

0.3 portion of 10 percent sodium hydroxide

100 portions of water

(3) Homogenizing the water phase when the oil phase is dissolved and reaches a set temperature, directly adding the oil phase under the condition of homogenizing 7200rpm, and homogenizing for 6 min;

(4) adding one third of 10% sodium hydroxide solution into the emulsion during homogenization;

(5) taking the homogenized emulsion out of the constant-temperature water bath kettle, and stirring and cooling at the external temperature of 28 ℃ and the rotating speed of 400 rpm; when the temperature drops to 45-50 ℃,3 parts of chamomillae herb and 1.0 part of PE-9010 and the remaining two thirds of 10% sodium hydroxide solution are added.

The obtained product is pink and sticky emulsion, is safe, mild and non-irritating, and has refreshing and non-greasy skin feeling.

Example 2 Effect of the emulsions of the invention on skin allergy symptoms

After the face is cleaned in the morning and evening every day, the shea butter allergic muscle full-effect repair emulsion is used as a skin care emulsion to be applied to the face of a patient with allergic phenomena such as eczema, acne, dry itching and red swelling, and the skin allergic part can be applied more intensively. After 8 hours, an anti-inflammatory, repairing effect was observed after absorption of the emulsion. Various allergic phenomena are obviously relieved. After the patients with severe symptoms use the traditional Chinese medicine for a plurality of days, the health state of the skin is obviously improved.

In 50 tested cases, the repairing and protecting effects on eczema of babies are obvious, the diaper rash and the like of common eczema can take effect within 8-10 hours, and the slightly stubborn eczema is obviously improved within 5 days. For comedo and pox, 50 cases of tests show that the feedback is improved by 50 cases, and the effective rate is 100%.

Specifically, after skin cleansing, a suitable amount of the Shea butter cream for total-effect repair of allergic muscles prepared in example 1 was applied to the skin of the face or body until absorption, and the sensitive parts such as pox, eczema, dry itch, and redness were applied with a small amount of emphasis. The paint is applied for 1-2 times every day.

The effect of use is shown in figures 1-6. The Shea butter allergic muscle full-effect repair milk can achieve a quick and effective treatment effect on skin allergic symptoms such as eczema, pox, dry itch and redness. As an innovative formula and a process of the whole plant oil phase, a product with obvious efficacy is prepared by selecting specific high-quality raw materials, and a solution is provided for solving the problem of skin allergy which troubles many people at present.

All documents referred to herein are incorporated by reference into this application as if each were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention can be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the present invention as defined by the appended claims.

Claims (10)

1. A shea butter emulsion comprising shea butter and a liquid crystal emulsifier, wherein the shea butter has a purity of greater than 99.9% and an acid number of less than 5; the liquid crystal emulsifier comprises 2 or more than 2 of lecithin emulsifier, sucrose ester emulsifier, glucoside emulsifier, phytosterol and higher fatty alcohol.

2. The shea butter emulsion of claim 1, wherein the liquid crystal emulsifier comprises lecithin emulsifiers, sucrose ester emulsifiers, glycoside emulsifiers, phytosterols and higher fatty alcohols.

3. The shea butter emulsion of claim 1 or 2, wherein the emulsion comprises the following components in parts by weight:

2.0-6.0 parts of liquid crystal emulsifier;

6.0-35.0 parts of grease, wherein the shea butter is 6-25 parts;

2.0-6.0 parts of a humectant;

0.01-0.10 part of sodium hyaluronate;

1.0-8.0 parts of water-soluble functional components;

0.1-0.5 part of thickening agent;

0.1-1.0 part of preservative;

water is added to 100.0 parts.

4. The shea butter emulsion of claim 3, wherein the water-soluble functional ingredient is one or more selected from allantoin, chamomile essence, astragaloside, purslane, bisabolol, scutellaria, paeoniflorin, bamboo leaf flavone, witch hazel, olive leaf extract, OPC Gludolan, dipotassium glycyrrhizinate, sea buckthorn oil, and salvia miltiorrhiza root extract;

and/or

Is selected from one or more of riboflavin, baicalein, and azelaic acid.

5. The shea butter emulsion of claim 3 wherein the fat is a vegetable fat; besides shea butter, the oil contains one or more vegetable oils and fats selected from almond oil, lithospermum oil, pomegranate oil, chamomile oil, balm essential oil, coconut oil, palm oil, olive oil, grape seed oil, mango seed fat, camellia seed oil, sunflower seed oil, jojoba seed oil, walnut seed oil, Chinese chestnut seed oil, shea butter, evening primrose oil, avocado oil, wild soybean oil, cocoa seed fat, carnauba wax and olive oil.

6. A cosmetic composition comprising the shea butter emulsion of any one of claims 1-5.

7. A pharmaceutical composition comprising the shea butter emulsion of any one of claims 1-5 and optionally a pharmaceutically acceptable carrier.

8. Use of the shea butter emulsion of any one of claims 1-5 in the preparation of a cosmetic or pharmaceutical composition.

9. A method of preparing a shea butter emulsion according to any one of claims 1-5, comprising the steps of:

1) weighing a liquid crystal emulsifier and grease containing shea butter as oil phases, and preheating the oil phases;

2) weighing humectant, sodium hyaluronate, water-soluble effective component and thickener as water phase, and preheating;

3) after the oil phase is dissolved, homogenizing the water phase, and directly adding the oil phase under the homogenization condition;

4) stirring the emulsion at room temperature to reduce the temperature; adding antiseptic into the emulsion, stirring to room temperature, and packaging.

10. The method of claim 9, comprising the steps of:

1) weighing the following raw materials in parts by weight as an oil phase, and putting the oil phase into a constant-temperature water bath kettle at 70-78 ℃ for preheating;

2.0-6.0 parts of liquid crystal emulsifier;

6.0-35.0 parts of grease, wherein the shea butter is 6-25 parts;

2) weighing the following raw materials in parts by weight as a water phase, and preheating the water phase in a constant-temperature water bath kettle at 70-78 ℃;

2.0-6.0 parts of a humectant;

0.01-0.10 part of sodium hyaluronate;

1.0-8.0 parts of water-soluble functional components;

0.1-0.5 part of thickening agent;

adding water to 100.0 parts;

3) homogenizing the water phase when the oil phase is dissolved and reaches a set temperature (70-78 deg.C according to the oil phase composition), and directly adding the oil phase under the condition of homogenization (the homogenization rate is adjusted at 4000-8000rpm according to the system), and homogenizing for 5-8 min;

4) taking the emulsion out of the constant-temperature water bath kettle, and stirring and cooling at the external temperature of 25-28 ℃ and the rotation speed of 300-; when the temperature is reduced to 45-50 ℃, 0.1-1.0 part of preservative is added into the emulsion, the mixture is continuously stirred to the room temperature, and then the mixture is packaged.

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