CN114588078A - Self-emulsifying functional oil phase and preparation method and application thereof - Google Patents

Abstract

The invention provides a self-emulsifying functional oil phase and a preparation method thereof. The oil phase comprises grease with skin care effect and grease with emulsification effect. The self-emulsifying functional oil phase disclosed by the invention has the skin repairing effect, can effectively resist oxidation and various skin problems, is strong in water locking property, is capable of relieving and moisturizing, is convenient for exerting the performance of functional components in a product, can obviously increase the efficacy of the product, and is high in safety. The oil phase has the emulsification function, is convenient to use, simple to operate, wide in compatibility, capable of being matched with various water phase components for use, and easy to popularize. Specialties are the preparation of oil-in-water emulsion products such as efficacious lotions, creams and the like directed at skin problems.

Description

Self-emulsifying functional oil phase and preparation method and application thereof

Technical Field

The present invention relates to the field of cosmetics. Specifically, the invention relates to a self-emulsifying functional vegetable oil phase which is obtained by mixing functional oil for solving skin problems and oil with an emulsifying function according to a certain proportion, and has skin problem solving and emulsifying functions, and a preparation method and application thereof.

Background

In china, nearly 80% of women have skin problems. 72% of the population consciously perceive the skin as sub-healthy, and 14% consider themselves to have significant skin disease. For dealing with skin problems, 64% are preferably self-administered or tolerated, and 35.75% consider the dermatology department to be seen in time. Even 45% of college students with poor skin condition have affected mental health problems such as unconsciousness, social interaction, and job hunting. Common skin problems include: dry and desquamate skin, wrinkle (french line, raised line, eye line, fishtail line, etc.), coarse pore, blackhead, acne, pox, color spot, dark skin color, scar, striae gravidarum, chilblain, eczema, skin allergy, etc.

In fact, the skin presents problems mainly with impaired skin barrier. The skin barrier is the first line of defense of the human body, and the healthy skin barrier can resist external harmful substances, stimulation and sunlight entering and has the effects of moisturizing and regulating. However, when the skin barrier is fragile or damaged, the skin cannot adapt to the change of the external environment, so that the skin is easy to be aged, sensitive, inflammatory, color spot and other reactions, and a lot of troubles are brought to the skin.

The self-emulsifying efficacy oil phase of the invention can well solve the above problems.

Disclosure of Invention

The invention aims to provide a solution for solving various skin problems, which is a self-emulsifying efficacy oil phase solution which is applied to a problem skin solution, can solve various skin problems, has the advantages of safety, health, high cost performance, convenience and easy popularization, and can obtain oil-in-water emulsified cosmetics such as emulsion, cream and the like with various performances and obvious efficacy by mixing and homogenizing the oil-in-water emulsified cosmetics with required water phase at a proper temperature. Thereby making up the vacancy of the functional oil phase intermediate in the current market.

The self-emulsifying oil phase intermediate is prepared by selecting oils with different efficacies according to different skin problems, selecting different oils with emulsifying capacity according to different efficacy oils, and physically mixing solid and liquid plant oils with various efficacies and oils with emulsifying functions at a certain temperature according to a specific ratio and a method. The vegetable oil with self-emulsifying effect can be ensured to exert the maximum skin care effect of the mixture.

The self-emulsifying vegetable oil phase is very simple to use, provides a water phase reference formula, is compatible with any water phase component, is convenient to operate, does not need to add an emulsifier, an auxiliary agent and the like, and is specially prepared for oil-in-water emulsion products such as functional emulsion, cream and the like. The user can refer to the provided water phase formula to develop the efficacy cosmetics, and the research and development efficiency is greatly improved.

The functional skin care product prepared by the self-emulsified plant oil phase has the advantages that plant functional components restore skin barriers and help the functional components to quickly permeate into a skin brick structure, so that the corresponding effects are quick, obvious and safe, no side effect is caused, and safety and effect are both considered.

In a first aspect, the present invention provides a self-emulsifying efficacy oil phase comprising an oil having at least 2 skin care effects, and an oil having an emulsifying efficacy; the oil and fat with the emulsification effect comprises oil and fat with oil-in-water emulsification effect, such as lecithin emulsifiers, phytosterols, higher fatty alcohols and the like.

In a specific embodiment, the skin-care efficacy oil or fat is shea butter and two or more of vegetable oils or fats having skin-care efficacy selected from the group consisting of: castor oil, avocado oil, olive oil, jojoba seed oil, walnut oil, safflower seed oil, soybean oil, sunflower seed oil, olive oil, borage oil, aloe oil, green tea seed oil, rose hip oil, rice bran oil, pumpkin seed oil, grapeseed oil, sea buckthorn fruit oil, sea buckthorn seed oil, camellia seed oil, pomegranate seed oil, sweet almond oil, wheat germ oil, monkey-bread seed oil, linseed oil, coconut oil, evening primrose oil, hazelnut oil, sesame oil, perilla seed oil, palm oil, millet bran oil, moringa seed oil, egg yolk oil, red pine seed oil, violet grass oil, bitter almond oil, peony seed oil, calendula soaking oil, nut oil, oat oil, cactus seed oil, black seed oil, aloe oil, coconut oil, rose essential oil, permanent flower essential oil, bitter orange flower essential oil, sweet osmanthus flower essential oil, gardenia essential oil, tuberose essential oil, white tea essential oil, jasmine oil, safflower seed oil, sesame seed oil, safflower seed oil, linseed oil, and the like, Acacia essential oil, amber essential oil, honeysuckle essential oil, sophora flower essential oil, magnolia essential oil, violet essential oil, ylang essential oil, chamomile essential oil, rose geranium essential oil, vetiver essential oil, lemon balm essential oil, rose grass essential oil, perilla leaf essential oil, bitter orange leaf essential oil, clary sage essential oil, lavender essential oil, wormwood essential oil, thyme essential oil, clove essential oil, lemon grass essential oil, citronella essential oil, lemon eucalyptus essential oil, spearmint essential oil, mint essential oil, tea tree essential oil, eucalyptus leaf essential oil, eucalyptus essential oil, cajeput essential oil, bay oil, linaloe essential oil, wintergreen essential oil, fir essential oil, pine essential oil, bergamot essential oil, grapefruit essential oil, lemon essential oil, sweet orange essential oil, tangerine essential oil, eaglewood essential oil, eagle wood essential oil, tangerine essential oil, eaglewood essential oil, orange essential oil, tangerine essential oil, eaglewood essential oil, sweet wood oil, sweet orange essential oil, tangerine essential oil, orange essential oil, sweet eaglewood oil, sweet orange essential oil, sweet eaglewood essential oil, sweet wood, Saffron essential oil, sandalwood essential oil, ginseng oil, salvia miltiorrhiza oil, sophora flavescens essential oil, angelica dahurica essential oil, rhodiola rosea essential oil, valerian oil, carrot seed essential oil, divaricate saposhnikovia root essential oil, bighead atractylodes rhizome oil, rosewood oil, costus oil, asarum oil, nutgrass galingale rhizome oil, ginger oil resin, storax oil, zedoary oil, magnolia flower oil, brucea javanica oil, amomum oil, houttuynia cordata oil, coriander essential oil, patchouli essential oil, myrrh essential oil, vitex oil, curcuma oil, nardostachyos root oil, fennel essential oil, sweet fennel essential oil, star anise oil, cardamom oil, magnolia officinalis oil, nutmeg essential oil, cnidium oil, garlic essential oil, eucommia ulmoides oil, schisandra chinensis oil, forsythia suspensa oil, cassia twig oil, cinnamon leaf essential oil, zanthoxylum bungeanum oil, litsea cubeba oil, mustard oil and white mustard oil.

In a specific embodiment, the self-emulsifying efficacy oil phase comprises the following ingredients in parts by weight:

15.0-20.0 parts of grease with an emulsifying effect;

80.0-85.0 parts of grease with skin care efficacy.

In a specific embodiment, the oil and fat with emulsification efficacy comprises an oil-in-water type emulsifier, including but not limited to lecithin type emulsifiers, alkyl glycoside type emulsifiers, sucrose ester type emulsifiers, phosphate ester type emulsifiers, olive esters type emulsifiers, stearoyl type emulsifiers, and the like.

In a preferred embodiment, the self-emulsifying functional vegetable oil phase is prepared by mixing the skin-care functional oil and the emulsifying functional oil in a specific ratio and operation method.

In a second aspect, the present invention provides a cosmetic composition comprising the self-emulsifying efficacy oil phase of the first aspect.

In a third aspect, the present invention provides a pharmaceutical composition comprising the self-emulsifying functional oil phase of the first aspect and optionally a pharmaceutically acceptable carrier.

In a preferred embodiment, the pharmaceutical composition is a topical pharmaceutical composition.

In a fourth aspect, the present invention provides the use of a self-emulsifying efficacy oil phase according to the first aspect in the preparation of a cosmetic or pharmaceutical composition.

In a fifth aspect, the present invention provides a method for preparing the self-emulsifying efficacy oil phase of the first aspect, comprising the steps of:

1) weighing solid oil and functional solid oil with emulsifying function, such as shea butter, cacao butter, hydrogenated soft phospholipid, etc. in a constant temperature device (temperature is determined according to oil properties), and melting at proper temperature;

2) weighing liquid grease with emulsibility and efficacy according to a certain weight part, and putting the liquid grease into a constant temperature device for preheating;

3) and (3) directly adding the preheated liquid grease into the melted solid grease, and stirring and mixing.

4) Stirring the uniformly mixed grease at a certain rotating speed (300-500rpm), cooling to a certain temperature (30-40 ℃), and canning to obtain the oil phase with the emulsification effect.

In a sixth aspect, the present invention provides a method of treating, ameliorating or alleviating the symptoms of a skin problem comprising administering to a subject in need thereof a cosmetic composition according to the second aspect, or a pharmaceutical composition according to the third aspect.

In a preferred embodiment, the subject is a mammal, preferably a human.

In preferred embodiments, the skin problem symptoms include, but are not limited to, eczema, acne marks, darkness, allergies, dry itching, redness, wrinkles, aging, scars, stretch marks, chilblain, and other skin symptoms.

It is to be understood that within the scope of the present invention, the above-described features of the present invention and those specifically described below (e.g., in the examples) may be combined with each other to form new or preferred embodiments. Not to be reiterated herein, but to the extent of space.

Drawings

Fig. 1 shows the self-emulsifying plant oil phase with anti-acne efficacy prepared in example 1;

fig. 2-4 show the efficacy of a plant anti-acne lotion formulated with the self-emulsifying anti-acne oil phase of the present invention on acne, pox;

FIGS. 5-7 show the efficacy of a eczema-reducing lotion formulated with a self-emulsifying, anti-allergic oil phase of the present invention on eczema;

figure 8 shows the efficacy of a phytoscar-repairing lotion formulated with the self-emulsifying scar-repairing oil phase of the present invention on de novo scarring.

Detailed Description

The inventor finds in research that no domestic cosmetic with quick effect, obvious effect, no side effect and high cost performance on problem skin appears at present. The inventor unexpectedly discovers that certain vegetable oil with specific effects and certain oil with emulsification effects are mixed according to a specific proportion formula and a water phase formula, and the prepared skin care product can quickly, effectively and comprehensively relieve all skin symptoms with problems, particularly can simultaneously play a role in treating acne, eczema and various skin allergy symptoms and has obvious effect on various skin problems such as skin darkness, scars, striae gravidarum, chilblain and the like. The present invention has been completed based on this finding.

Problematic skin symptoms

Several major symptoms of skin problems include:

eczema is a common skin disease in modern society, and patients with eczema can be in different age groups and are common to infants. Eczema is a common inflammatory skin disease of epidermis and dermis superficial layer caused by various internal and external factors. Eczema has a complex pathogenesis, and is mainly a delayed allergic reaction caused by complex internal and external exciting factors. The sensitivity of a patient is very strong, a lot of substances can be positively reacted during a patch test, but eczema cannot disappear quickly after the sensitization factors are removed; some patients can change the reactivity of the organism by strengthening exercise, changing the environment and the like, and can not have eczema when receiving various factors which induce the eczema in the past, which all show the complexity of the pathogenesis of the eczema. The subjective symptoms are intense in pruritus. If the acute and subacute eczema is not treated actively, the acute and subacute eczema can be converted into chronic eczema if the acute and subacute eczema is not cured repeatedly, the skin damage is dark red or brownish red spots or maculopapules, the skin damage is often combined and thickened to become lichenification, scales, scratches and blood crusts are formed on the surface of the skin, and the skin damage is scattered on a few papules, maculopapules and the like. And the disease is repeatedly developed at this time.

The current treatment method for eczema comprises the following steps: at present, no specific therapy for eczema skin diseases is available, and internal antihistamine medicines and corticoid medicines are mostly adopted for temporary inhibition, such as oral western medicines, oral hormones, external solution lotions, emulsions, mud pastes, oil solutions, ointments, emulsions, film coatings, tinctures, hard pastes and the like.

Acne, also known as "whelk", "acne", "comedo" or "pockmark". The pathogenesis of pox is recognized to be mainly four aspects: hyperkeratosis of the epithelium of hair follicles and sebaceous glands; sebaceous gland mass secretion; colonization by microorganism (Propionibacterium acnes, Malassezia); inflammation and immune response. In adolescence, a large amount of androgen is secreted, so that the proliferation and abnormal keratinization of the epiderm of a pilosebaceous canal are promoted, acne is formed, and pores are blocked. The sebaceous gland secretes a large amount, and the androgen can cause the blockage of a hair follicle duct and can also secrete a large amount of sebum by stimulating the sebaceous gland. Two major microorganisms live in the follicular ducts: propionibacterium acnes and Malassezia are propagated in large quantities. The exuberant sebum secretion tends to accumulate dirt, especially fat-soluble organic substances and many kinds of microorganisms, which induce inflammation and infection. The pores are large, so that bacteria, fungi, viruses and the like can be easily driven in directly to cause infection, thereby causing inflammatory reaction, and acne generates comedones.

The current treatment method for pox comprises the following steps: acne is caused by the fact that sebaceous gland secretion is vigorous due to simple endocrine disturbance, and the symptoms caused by overhigh androgen level can be considered by using estrogen medicines, and the oil secretion is reduced so as to improve the symptoms of the acne; if the follicular orifice is large due to follicular keratosis and then the sebaceous gland duct is blocked, closed-pore pox can occur, the treatment can be carried out by using a medicament for softening the cutin, such as vitamin A acid cream or salicylic acid cream; pox presents an infection that generally requires topical mupirocin cream treatment, and in severe cases oral tetracycline antibiotic treatment is also contemplated.

3, the skin is allergic,

skin allergy refers to skin that is easily irritated and causes some discomfort. When the external environment changes, the skin cannot be adjusted, and uncomfortable feeling and allergy phenomena occur. Skin allergy can be divided into dry skin, oily skin and mixed skin. If allergy occurs, it may cause symptoms such as red rash, itching, blisters, red swelling, etc. Skin allergy may be caused by exposure to allergic substances, such as food with allergic properties, the administration of certain drugs, etc. Or damage of skin surface barrier caused by cosmetic containing harmful stimulation component, frequent skin caring, frequent cutin removal, etc., which causes skin sensitivity and resistance to external stimulation, and sunburn ultraviolet radiation

Excessive ultraviolet rays can cause skin burns at any time, and dire allergic symptoms such as erythema, blackening, desquamation and the like appear. Solar dermatitis, also known as sunburn or sunburn, is an acute inflammatory response produced by exposure of normal skin to the sun, manifested as erythema, edema, blisters, pigmentation, and desquamation. The disease is common in late spring and early summer, is better to children, women, skiers and water surface workers, and the reaction intensity is related to the intensity of light, irradiation time, individual skin color, physique, ethnicity and the like.

5, the scar is formed,

the scar is a necessary physiological reaction in the natural healing process of a wound or a wound surface after a human body is wounded, a necessary product in the process of repairing the human body wound, and the main component of scar tissue is fibrin.

The scar is a local symptom which is caused by that the damage of physical, biological, chemical and other factors acts on the skin soft tissue of a human body to cause the serious damage of the skin soft tissue and can not be completely and normally repaired, and the fibrous tissue replaces and repairs the remained part which influences the appearance and the function. The scar brings great physical and mental pains to patients, especially scars left after burns, scalds and serious trauma.

6 striae gravidarum

The striae gravidarum is a pink or purplish red wavy pattern with different widths and lengths, which is formed by the fact that the abdominal bulge makes the elastic fibers and the collagen fibers of the skin damaged or broken after pregnancy, and the abdominal skin becomes thinner and thinner. After delivery, these patterns gradually disappear, leaving white or silvery-white, shiny scar lines, i.e. stretch marks. 70-90% of pregnant women will develop stretch marks.

Scars and stretch marks cause inconvenience to patients, and the beauty and confidence are seriously affected. There is currently no solution that is very beneficial for scar management and stretch marks.

7, wrinkles

The wrinkles refer to small fine lines and wrinkles formed by the skin affected by external environment to form free radicals, and the free radicals destroy collagen and active substances in normal cell membrane tissues and oxidize cells. Wrinkles gradually appear. The order of appearance is typically forehead, upper and lower eyelids, outer canthus, anterior auricular region, cheek, neck, chin, perioral. The facial wrinkles are classified into two types, atrophy wrinkles and hypertrophic wrinkles. Atrophic wrinkles refer to wrinkles that appear on thin, easily breakable and dry skin, such as countless fine wrinkles around the eyes; the hypertrophic wrinkles are the most recent finding indicating the formation of wrinkles, which are present on oily skin, in small numbers and in dense and deep textures, such as wrinkles on the forehead, around the lips, and in the mandible.

Mainly caused by photoaging, habitual expressions, skin water shortage, working pressure, irregular life, insufficient sleep, even subcutaneous fat reduction due to weight loss. Photoaging is a major cause of pseudo-wrinkles in the skin, and ultraviolet rays cause skin to lack water and form small breaks, which are reflected in the face as a fine wrinkle, and the wrinkles formed by dryness, also called "dry lines", are the leading skin problems in young people of about 20 years old in recent years.

8, dark and long-colored skin

The long-term exposure to air pollution environments such as ultraviolet rays, electromagnetic waves, computer screens, smoking and the like can easily stimulate the body to generate excessive free radicals, so that the aging of the horny layer is caused, and the oxidation of the horny layer is also the main reason that the skin color does not appear glossy. The oxidized epidermis of the skin is injured and disorganized, making the skin feel rough on its surface and then look dark. Abnormal work and rest can lead to the reduction of the metabolic capacity of the body, influence the generation and metabolism of melanin, reduce the repair capacity of the epidermis, and possibly cause endocrine disturbance, thereby influencing the skin. In the process of attacking and destroying cells, a large amount of cells die and are disordered in metabolism, impurities in the cells cannot be metabolized, so that pigment deposition is caused, the number of new cells is greatly reduced (the new cells are important factors for whitening skin), and facial color spots are formed.

9, chilblain

Chilblain is common in winter, and severe people can have blisters and ulcers due to repeated erythema and swelling damage of local skin caused by cold weather, the course of disease is slow, and the chilblain is self-healed after the weather is warm and is easy to relapse.

Chilblain is usually caused in early winter and early spring, and most of children, women and peripheral poor blood circulation are accompanied by cold skin at the tail end of limbs, cyanosis of the extremities, hyperhidrosis and the like. Skin lesions are usually located on the fingers, back of hand, face, pinna, toes, edges of feet, and heel, and often distributed on both sides. The common lesions are localized gorgeous dark purplish red raised edematous erythema, unclear boundaries, bright red edges, tense and glossy surfaces and soft quality. The color of the product can be faded by local pressing, and the red color can be gradually recovered after the pressure is removed. In severe cases, blisters may develop, rupture to form erosions or ulcers, and the healed skin may contain pigmentation or atrophic scars. Itching is obvious, aggravated after being heated and pain after ulceration.

In summary, the pathogenesis of various skin problems is completely different. At present, the skin care product has no specific therapy to skin problems, takes effect quickly, has obvious effect and has no side effect on human bodies after being used for a long time. The invention fills the blank of effectively treating skin problems such as eczema, acne, sensitive skin, sunburn, scars, striae gravidarum, dark and dull spots, wrinkles, chilblain and the like. And moreover, the effective oil is mainly vegetable oil, so that the skin barrier is repaired and enhanced through water-oil balance, and no side effect is caused to a human body. And the more targeted emulsified oil is selected, so that the prepared skin care product has the advantages of similarity to the structure of a human body, product efficacy increase, intentional stability and good vision and skin feeling.

Self-emulsifying functional oil phase

In the present invention, "self-emulsifying efficacy oil phase", "self-emulsifying repair oil phase", "oil phase intermediate of the present invention" or "efficacy emulsified oil" and "efficacy emulsified wax" have the same meaning. These terms are intended to include specific skin care oils and oil mixtures with emulsifying efficacy.

The grease with skin care effect comprises: shea butter, castor oil, avocado oil, olive oil, jojoba seed oil, walnut oil, safflower seed oil, soybean oil, sunflower seed oil, olive oil, borage oil, aloe oil, green tea seed oil, rose hip oil, rice bran oil, pumpkin seed oil, grapeseed oil, sea buckthorn fruit oil, sea buckthorn seed oil, camellia seed oil, pomegranate seed oil, sweet almond oil, wheat germ oil, linseed oil, coconut oil, macadamia oil, evening primrose oil, hazelnut oil, sesame oil, perilla seed oil, palm oil, millet bran oil, moringa seed oil, egg yolk oil, red pine seed oil, lithospermum oil, bitter almond oil, peony seed oil, calendula officinalis soaking oil, nut oil, oat oil, cactus seed oil, aloe oil, coconut oil, rose essential oil, permanent flower essential oil, bitter orange flower essential oil, sweet osmanthus flower essential oil, gardenia essential oil, tuberose essential oil, safflower oil, soybean oil, sunflower seed oil, olive oil, borage oil, corn oil, safflower oil, corn oil, safflower oil, corn oil, White tea essential oil, jasmine essential oil, acacia essential oil, amber essential oil, honeysuckle essential oil, sophora flower essential oil, magnolia flower essential oil, violet essential oil, cananga essential oil, chamomile essential oil, rose geranium essential oil, vetiver essential oil, lemon balm essential oil, rose geranium essential oil, perilla leaf essential oil, bitter orange leaf essential oil, clary sage essential oil, lavender essential oil, wormwood essential oil, sweet wormwood essential oil, clove essential oil, lemon grass essential oil, citronella essential oil, lemon eucalyptus essential oil, spearmint essential oil, mint essential oil, tea tree essential oil, eucalyptus globulus essential oil, bay oil, linaloe essential oil, wintergreen essential oil, cedar essential oil, pine needle essential oil, bergamot essential oil, grapefruit essential oil, lemon essential oil, sweet orange essential oil, tangerine essential oil, honeysuckle essential oil, geranium essential oil, geran, Tangerine essential oil, agilawood essential oil, saffron essential oil, sandalwood essential oil, ginseng oil, salvia miltiorrhiza oil, sophora flavescens essential oil, angelica dahurica essential oil, rhodiola rosea essential oil, valerian oil, carrot seed essential oil, divaricate saposhnikovia root essential oil, bighead atractylodes rhizome oil, rosewood oil, costus oil, asarum oil, nutgrass galingale rhizome oil, ginger oleoresin, storax oil, zedoary turmeric oil, magnolia flower oil and brucea javanica oil, two or more vegetable oils of oleum Ormosiae Semicastratae, herba Houttuyniae oil, herba Coriandri essential oil, herba Agastaches essential oil, Myrrha essential oil, oleum Viticis negundo, Curcuma rhizome oil, radix Et rhizoma Nardostachyos oil, fructus Foeniculi essential oil, sweet fructus Foeniculi essential oil, fructus Anisi Stellati oil, fructus Amomi rotundus oil, cortex Magnolia officinalis oil, semen Myristicae essential oil, cnidium fruit oil, Bulbus Allii essential oil, Eucommiae cortex oil, fructus Schisandrae oil, fructus forsythiae oil, ramulus Cinnamomi oil, oleum Cinnamomi, folium Cinnamomi essential oil, fructus Zanthoxyli oil, fructus Litseae oil, mustard oil, and semen Sinapis Albae oil.

The self-emulsifying functional oil phase also contains oil with an emulsifying function, so that the functional skin care product prepared from the functional oil can moisten skin and repair cutin, and has extremely high skin safety. The emulsion has the advantages that the emulsion is more targeted for use of emulsified oil, the excellent emulsification effect is ensured, various functional components can be compatible, the emulsion effect is obviously improved, water-soluble substances and the functional components can be effectively protected, the moisture retention property of the emulsion is improved, and the performance of the functional components in the emulsion is promoted.

In a specific embodiment, the oil or fat having an emulsifying effect is an oil-in-water type emulsifier, including but not limited to lecithin type emulsifiers, alkyl glycoside type emulsifiers, sucrose ester type emulsifiers, phosphate ester type emulsifiers, olive esters, and stearyl type emulsifiers.

The invention has the advantages that:

1. the self-emulsifying efficacy plant oil phase provided by the invention fills up the blank of the market for the efficacy oil phase;

2. the technical difficulty is solved for medium and small cosmetic substitute enterprises, the research and development investment is reduced, and the output efficiency is improved;

3. according to the market demand, the product with the skin effect of different problems is customized individually;

4. the self-emulsifying functional oil phase disclosed by the invention completely does not contain any substances harmful to the skin while ensuring the efficacy, is safe and healthy, and improves the life quality of people;

5. the use is simple and convenient, the compatibility with water phase is high, and the product can be compatible with any functional product;

6. the skin care product prepared by the water-locking and moisture-retaining agent has strong water-locking and moisture-retaining property and excellent slow release property, maintains the activity of functional components in a system, and obviously increases the efficacy of the product;

7. the skin care product prepared by the method has excellent stability, ion resistance, acid and alkali resistance and strong temperature resistance;

8. the skin care product prepared by the method has good vision and excellent skin feeling.

The invention will be further illustrated with reference to the following specific examples. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Experimental procedures in the following examples, where specific conditions are not indicated, are generally carried out according to conventional conditions, or according to conditions recommended by the manufacturer. Unless otherwise indicated, percentages and parts are by weight.

Example 1 preparation and application of self-emulsifying oil phase with acne-removing efficacy

The formula of the self-emulsifying acne-removing efficacy oil phase is as follows (the parts are shown in parts by weight):

15 parts of emulsifier (hydrogenated lecithin, phytosterol, behenyl alcohol, stearyl alcohol and cetyl alcohol)

Shea butter 35 parts

15 portions of olive oil

Sweet almond oil 8 parts

1.5 parts of chamomile oil

8 parts of bran distillate oil

Lithospermum oil 18 parts

The preparation method of the self-emulsifying acne-removing oil phase comprises the following steps:

(1) weighing the solid raw materials (shea butter, hydrogenated lecithin, cetyl alcohol and the like) in parts by weight, and putting the solid raw materials into a constant-temperature water bath kettle at 75 ℃ for melting at a proper temperature;

(2) weighing the liquid raw materials (arnebia oil, olive oil, sweet almond oil, bran distillate oil, chamomile oil, phytosterol and the like) in parts by weight, and preheating the liquid raw materials in a constant-temperature water bath kettle at 75 ℃;

(3) when the solid oil is dissolved and reaches a set temperature (70-80 ℃ according to the oil phase composition), directly adding the liquid oil under the condition of homogenization (the homogenization rate is adjusted to 4000-8000rpm according to the difference of a system), homogenizing for 5-8min, and uniformly mixing;

4) taking the mixed self-emulsified acne-removing oil phase out of a constant-temperature water bath kettle, and stirring and cooling at the external temperature of 25-28 ℃ and the rotating speed of 300-500 rpm; stirring to room temperature, and packaging.

The obtained product, namely the self-emulsifying acne-removing oil phase, is a light yellow viscous semi-liquid, and is safe, mild and non-irritating.

The application of the self-emulsifying acne-removing oil phase comprises the following steps:

to provide the customer with an aqueous phase reference formula, the plant anti-acne lotion was formulated using this self-emulsifying oil phase by the following steps.

(1) Heating the water phase components by a client at 73-75 ℃ and uniformly mixing;

(2) heating the emulsified oil phase with the acne removing effect to 75 ℃, uniformly mixing, and slowly pouring into the water phase;

(3) homogenizing and stirring for 8-10 minutes, and uniformly mixing;

(4) stirring and cooling, wherein when cooling is started, the pH is adjusted; then adding a preservative; after cooling slightly, adding functional components needing to be added at low temperature.

Example 2 preparation and use of self-emulsifying desensitizing oil phase

The formula of the self-emulsifying anti-allergy oil phase is as follows (the parts are shown as parts by weight):

15 parts of emulsifier (hydrogenated lecithin, phytosterol, behenyl alcohol, stearyl alcohol and cetyl alcohol)

Shea butter 35 parts

15 portions of olive oil

Sweet almond oil 8 parts

Egg oil 2 parts

8 parts of bran distillate oil

Lithospermum oil 15 parts

The preparation of the emulsion comprises the following steps:

(1) weighing the solid raw materials (shea butter, hydrogenated lecithin, cetyl alcohol and the like) in parts by weight, and putting the solid raw materials into a thermostat water bath kettle at 75 ℃ for melting at a proper temperature;

(2) weighing the liquid raw materials (olive oil, sweet almond oil, bran oil, egg yolk oil, phytosterol and the like) in parts by weight, and preheating the liquid raw materials in a constant-temperature water bath kettle at 75 ℃;

(3) when the solid oil phase is dissolved and reaches a set temperature (set according to the composition of the oil phase, 70-80 ℃), directly adding the liquid oil phase under the condition of homogenization (the homogenization rate is adjusted to be 4000-8000rpm according to the difference of the system), homogenizing for 5-8min, and uniformly mixing;

4) taking the mixed self-emulsifying anti-allergic oil phase out of the constant-temperature water bath kettle, and stirring and cooling at the external temperature of 25-28 ℃ and the rotating speed of 300-500 rpm; and continuously stirring to room temperature, and packaging.

The obtained product is light yellow viscous semi-liquid, and is safe, mild and non-irritating.

Application of the self-emulsifying anti-allergic oil phase:

to provide the customer with an aqueous reference formula, a plant rash removing baby lotion was formulated using the self-emulsifying oil phase by the following procedure.

(1) Heating the water phase components by a client at 73-75 ℃ and uniformly mixing;

(2) heating the emulsified oil phase with the acne removing effect to 75 ℃, uniformly mixing, and slowly pouring into the water phase;

(3) homogenizing and stirring for 8-10 minutes, and uniformly mixing;

(4) during stirring and cooling, wherein when cooling is started, the pH is adjusted; then adding a preservative; after cooling slightly, adding functional components needing low-temperature addition.

Example 3 preparation and application of self-emulsifying scar repairing oil phase

The formula of the self-emulsifying scar repairing oil phase is as follows (the parts are shown in parts by weight):

15 parts of emulsifier (hydrogenated lecithin, phytosterol, behenyl alcohol, stearyl alcohol and cetyl alcohol)

Shea butter 35 parts

15 portions of olive oil

Sweet almond oil 8 parts

Egg oil 1.5 parts

8 parts of bran distillate oil

Lithospermum oil 18 parts

The preparation of the oil phase comprises the following steps:

(1) weighing the solid raw materials (shea butter, cocoa butter, hydrogenated lecithin, cetyl alcohol and the like) in parts by weight, and putting the solid raw materials into a constant-temperature water bath kettle at 75 ℃ for melting at a proper temperature;

(2) weighing the liquid raw materials (olive oil, sweet almond oil, bran oil, egg yolk oil, phytosterol and the like) in parts by weight, and preheating the liquid raw materials in a constant-temperature water bath kettle at 75 ℃;

(3) when the solid oil phase is dissolved and reaches a set temperature (set according to the composition of the oil phase, 70-80 ℃), directly adding the liquid oil phase under the condition of homogenization (the homogenization rate is adjusted to be 4000-8000rpm according to the difference of the system), homogenizing for 5-8min, and uniformly mixing;

4) taking the mixed self-emulsifying efficacy oil phase out of the constant temperature water bath kettle, and controlling the external temperature to be 25-28 ℃.

Application of self-emulsifying scar repairing oil phase:

the self-emulsifying oil phase is used for preparing the phytoscar repairing emulsion by the following steps

(1) In order to provide a water phase reference formula for a client, the client heats and uniformly mixes water phase components at 73-75 ℃;

(2) heating the emulsified oil phase with the acne removing effect to 75 ℃, uniformly mixing, and slowly pouring into the water phase;

(3) homogenizing and stirring for 8-10 minutes, and uniformly mixing;

(4) during stirring and cooling, wherein when cooling is started, the pH is adjusted; then adding a preservative; after cooling slightly, adding functional components needing low-temperature addition.

Example 4 efficacy testing of a plant anti-acne emulsion formulated from a self-emulsifying anti-acne efficacy oil phase

In this example, the efficacy of the plant anti-acne lotion formulated with the self-emulsifying anti-acne oil phase of example 1 was tested.

50 cases of acnes and acnes are tested, and the 50 cases are improved, and the effective rate reaches 100%. The effect pairs before and after use are shown in figures 2-4.

Therefore, the plant acne-removing lotion has the effects of quick response (8-hour response and 5-day improvement), healthy skin repair, safety, no side effect and the like.

Example 5 efficacy testing of Damp rash baby emulsions formulated with self-emulsifying anti-allergic oil phase

In this example, the efficacy of a rash-eliminating baby emulsion formulated with the self-emulsifying, anti-allergic oil phase of example 2 was tested.

For the repair of eczema, the improvement is shown to be 45 cases in 50 cases of tests, and the effective rate reaches 90%. The effect pairs before and after use are shown in figures 5-7, and the effect on baby eczema, diaper rash and the like is obvious. In particular, the traditional Chinese medicine composition can take effect within 8-10 hours for common eczema and diaper rash, and can obviously improve slightly stubborn eczema within 5 days.

Therefore, the dampness and rash dispelling baby emulsion prepared from the self-emulsifying and anti-allergic oil phase has the effects of quick response, healthy skin restoration, safety and no side effect.

Example 6 efficacy testing of phytoscar repair emulsions formulated with self-emulsifying scar repair oil phase

In this example, the repair effect of phytoscar repair emulsions formulated using the self-emulsifying scar repairing oil phase of example 3 on new scars was tested.

The effect pairs before and after use are shown in fig. 8. As can be seen from the figure, the phytoscar repair emulsion has an obvious repair effect on new scars and can take effect within 8-10 hours.

All documents referred to herein are incorporated by reference into this application as if each had been individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention can be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the present invention as defined in the appended claims.

Claims (9)

1. A self-emulsifying efficacy oil phase comprising an oil having at least 2 skin care effects, and an oil having an emulsifying effect; the oil and fat with emulsification effect comprises oil and fat with oil-in-water emulsification effect, such as lecithin emulsifier, phytosterol, higher fatty alcohol, etc.

2. The self-emulsifying efficacy oil phase of claim 1, wherein the skin-care efficacy oil is shea butter and two or more skin-care efficacy vegetable oils selected from the group consisting of: castor oil, avocado oil, olive oil, jojoba seed oil, walnut oil, safflower seed oil, soybean oil, sunflower seed oil, olive oil, borage oil, aloe oil, green tea seed oil, rose hip oil, rice bran oil, pumpkin seed oil, grapeseed oil, sea buckthorn fruit oil, sea buckthorn seed oil, camellia seed oil, pomegranate seed oil, sweet almond oil, wheat germ oil, monkey-bread seed oil, linseed oil, coconut oil, evening primrose oil, hazelnut oil, sesame oil, perilla seed oil, palm oil, millet bran oil, moringa seed oil, egg yolk oil, red pine seed oil, lithospermum oil, bitter almond oil, peony seed oil, calendula soaking oil, nut oil, oat oil, cactus seed oil, black grass seed oil, aloe oil, coconut oil, rose essential oil, permanent flower essential oil, bitter orange flower essential oil, sweet osmanthus flower essential oil, gardenia flower essential oil, tuberose essential oil, white tea essential oil, jasmine essential oil, acacia oil, jasmine oil, safflower oil, sunflower seed oil, safflower oil, macadamia oil, black tea seed oil, black sesame seed oil, black tea seed oil, black bean oil, black sesame seed oil, black sesame oil, black, Amber essential oil, honeysuckle essential oil, sophora flower essential oil, magnolia flower essential oil, violet essential oil, cananga essential oil, chamomile essential oil, rose geranium essential oil, vetiver essential oil, melissa essential oil, rose essential oil, perilla leaf essential oil, bitter orange leaf essential oil, clary sage essential oil, lavender essential oil, wormwood essential oil, sweet wormwood essential oil, clove essential oil, lemon essential oil, citronella essential oil, lemon eucalyptus essential oil, spearmint essential oil, mint essential oil, tea tree essential oil, eucalyptus leaf essential oil, eucalyptus essential oil, melaleuca mollifolia essential oil, bay oil, linaloe essential oil, wintergreen essential oil, cedar essential oil, pine needle essential oil, bergamot essential oil, grapefruit essential oil, lemon essential oil, sweet orange essential oil, citrus essential oil, tangerine essential oil, agilawood essential oil, saffron essential oil, sandalwood essential oil, tangerine peel essential oil, tangerine essential oil, caraway essential oil, sandalwood essential oil, etc, Ginseng oil, salvia oil, sophora flavescens essential oil, angelica dahurica essential oil, rhodiola rosea essential oil, valerian oil, carrot seed essential oil, divaricate saposhnikovia root essential oil, bighead atractylodes rhizome oil, rosewood oil, costus oil, asarum oil, rhizoma cyperi oil, ginger oleoresin, storax oil, zedoary turmeric oil, magnolia flower oil, brucea javanica oil, Chinese amomum oil, houttuynia cordata oil, coriander essential oil, patchouli essential oil, myrrh essential oil, vitex oil, ginger butter, nardostachyos root oil, fennel essential oil, star anise oil, cardamom oil, magnolia officinalis oil, nutmeg essential oil, cnidium seed oil, garlic essential oil, eucommia ulmoides oil, schisandra chinensis oil, forsythia suspensa oil, cassia twig oil, cinnamon leaf essential oil, zanthoxylum bungeanum oil, litsea cubeba oil, mustard oil and white mustard oil.

3. The self-emulsifying efficacy oil phase of claim 1 comprising the following parts by weight:

15.0-20.0 parts of grease with an emulsifying effect;

80.0-85.0 parts of grease with skin care efficacy.

4. The self-emulsifying efficacy oil phase of claim 1, wherein the oil or fat with emulsification efficacy comprises an oil-in-water type emulsifier including, but not limited to, lecithin type emulsifiers, alkyl glycoside type emulsifiers, sucrose ester type emulsifiers, phosphate ester type emulsifiers, olive ester type emulsifiers, and stearoyl type emulsifiers.

5. A cosmetic composition comprising the self-emulsifying efficacy oil phase of any one of claims 1-4.

6. A pharmaceutical composition comprising the self-emulsifying efficacious oil phase of any one of claims 1-4 and optionally a pharmaceutically acceptable carrier.

7. Use of the self-emulsifying efficacy oil phase of any one of claims 1-4 in the preparation of a cosmetic or pharmaceutical composition.

8. A process for the preparation of a self-emulsifying efficacy oil phase as claimed in any one of claims 1 to 4 comprising the steps of:

1) weighing solid oil and functional solid oil with emulsifying function, such as shea butter, cacao butter, hydrogenated soft phospholipid, etc. in certain weight proportion, and melting at proper temperature in a constant temperature device.

2) Weighing liquid grease with emulsibility and efficacy according to a certain weight part, and putting the liquid grease into a constant temperature device for preheating;

3) and (3) directly adding the preheated liquid grease into the melted solid grease, and stirring and mixing.

4) Stirring the uniformly mixed grease at a certain rotating speed (300-500rpm), cooling to a certain temperature (30-40 ℃), and canning to obtain the oil phase with the emulsification effect.

9. A method of treating, ameliorating or alleviating the symptoms of a skin problem comprising administering the cosmetic composition of claim 5, or the pharmaceutical composition of claim 6 to a subject in need thereof.

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