CN114209626A - Acne-removing scar-removing composition and preparation method and application thereof - Google Patents
Acne-removing scar-removing composition and preparation method and application thereof Download PDFInfo
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- CN114209626A CN114209626A CN202111617128.9A CN202111617128A CN114209626A CN 114209626 A CN114209626 A CN 114209626A CN 202111617128 A CN202111617128 A CN 202111617128A CN 114209626 A CN114209626 A CN 114209626A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P17/10—Anti-acne agents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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Abstract
The invention relates to the technical field of daily chemical products, in particular to an acne-removing scar-removing composition and a preparation method and application thereof; the acne-removing scar-removing composition comprises centella total glycosides, salvia miltiorrhiza extracts, humectants, baicalin and sophora flavescens extracts; the preparation method of the acne-removing scar-removing composition comprises the following steps: heating pure water and keeping the temperature constant; adding asiaticoside and Saviae Miltiorrhizae radix extract into pure water, and stirring to obtain mixture I; adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring to obtain a second mixture; adding butanediol into the mixture II, stirring, and then filtering to obtain the acne and scar removing composition; the acne-removing scar-removing composition has the effects of recovering the health degree, elasticity and luster of the skin and solving the problems of long pox and pockmark marks caused by squeezing pox on the skin.
Description
Technical Field
The invention relates to the technical field of daily chemical products, in particular to an acne-removing scar-removing composition and a preparation method and application thereof.
Background
With the development of times, the pressure of work and life is higher and higher, and people often eat barbecue fried food all night, so that skin oil is excessively secreted, and acne easily grows. In particular, the acne pustules are squeezed without washing the hands clean, bacteria enter the subcutaneous space to cause more suppurative acne, and the squeezed acne forms pockmarks and scars. Most of acne removing products on the market have common acne removing effect or large stimulation, and are not suitable for pursuit of modern people. Meanwhile, the existing acne removing products on the market are difficult to effectively remove scars and acne marks caused by acne longissima or acne squeezing, and the overall using effect is poor.
Disclosure of Invention
The invention provides an acne-removing scar-removing composition, a preparation method and application thereof, and aims to help skin eliminate more suppurative acnes caused by bacteria entering the subcutaneous space due to exuberant sebum secretion, recover skin health degree, elasticity and luster and solve the problems of acne marks of long pockmarks and pockmarks caused by squeezing pockmarks on the skin.
The invention provides an acne-removing scar-removing composition which comprises the following components in percentage by weight:
further, the medicine composition also comprises baicalin, wherein the weight percentage of the baicalin is 0.5-5%.
Further, the total asiaticoside accounts for 3-10 wt%.
Further, the weight percentage of the salvia miltiorrhiza extract is 1-3%.
Further, the weight percentage of the sophora flavescens extract is 2-5%.
Further, the humectant is butylene glycol.
Furthermore, the asiaticoside is obtained by decocting asiatic centella with water, adsorbing the asiaticoside by a silica gel column, eluting, collecting eluent, concentrating and drying.
On the other hand, the invention also provides a preparation method of the acne-removing scar-removing composition, which comprises the following steps:
s1: heating pure water to 70-90 ℃ and keeping the temperature constant;
s2: adding the asiaticoside and the salvia miltiorrhiza extract into pure water in S1, and stirring for 15-25 minutes at the rotating speed of 200-250r/min to obtain a first mixture;
s3: adding the sophora flavescens extract and baicalin into the first mixture, and stirring for 15-25 minutes at the rotating speed of 200-250r/min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 8-12 minutes at the rotating speed of 200-250r/min, and then filtering by using filter cloth with 500-600 meshes to obtain the acne-removing and scar-removing composition.
In a third aspect, the invention also provides an application of the acne-removing scar-removing composition,
the acne-removing scar-removing composition is added into a face water, a facial mask, a gel or an essence.
Further, the acne-removing scar-removing composition is added into the face water, the facial mask, the gel or the essence in a weight percentage of 5-10%.
In summary, the present application has the following beneficial effects:
1. the centella asiatica is cold in nature, bitter and pungent in taste, has the effects of clearing heat, promoting diuresis, detoxifying and reducing swelling, can promote skin growth and has the effect of inhibiting skin scars, so that wounds caused by acne squeezing can be quickly healed, the skin with acne can be quickly healed, and the probability of generation of acne marks is reduced;
2. the radix sophorae flavescentis extract in the acne-removing scar-removing composition has the effects of resisting allergy, resisting inflammation, sterilizing and killing insects, so that the effects of eliminating skin acne inflammation and killing skin bacteria and mites are achieved, inflammation caused by acne can be relieved, and acne marks on skin can be prevented by sterilizing and killing insects;
3. the salvia miltiorrhiza bunge extract in the acne-removing scar-removing composition has the effects of promoting collagen proliferation and skin metabolism, so that the effect of promoting scar healing on the skin is achieved, and the formation probability of acne marks and scars is reduced.
Detailed Description
Example 1
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 80 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at rotation speed of 240r/min for 20 min to obtain a first mixture;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 240r/min for 20 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 10 minutes at the rotating speed of 240r/min, and then filtering by using a 550-mesh filter cloth to obtain the acne-removing and scar-removing composition.
Example 2
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 70 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at 200r/min for 15 min to obtain mixture I;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 200r/min for 15 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 8 minutes at the rotating speed of 200r/min, and then filtering by using 500-mesh filter cloth to obtain the acne and scar removing composition.
Example 3
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 90 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at 250r/min for 25 min to obtain mixture I;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 250r/min for 25 min to obtain second mixture;
s4: and adding butanediol into the mixture II, stirring for 12 minutes at the rotating speed of 250r/min, and then filtering by using 600-mesh filter cloth to obtain the acne and scar removing composition.
Example 4
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 80 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at rotation speed of 240r/min for 20 min to obtain a first mixture;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 240r/min for 20 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 10 minutes at the rotating speed of 240r/min, and then filtering by using a 550-mesh filter cloth to obtain the acne-removing and scar-removing composition.
Example 5
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 80 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at rotation speed of 240r/min for 20 min to obtain a first mixture;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 240r/min for 20 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 10 minutes at the rotating speed of 240r/min, and then filtering by using a 550-mesh filter cloth to obtain the acne-removing and scar-removing composition.
Example 6
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 80 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at rotation speed of 240r/min for 20 min to obtain a first mixture;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 240r/min for 20 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 10 minutes at the rotating speed of 240r/min, and then filtering by using a 550-mesh filter cloth to obtain the acne-removing and scar-removing composition.
Example 7
The acne-removing scar-removing composition comprises the following components in percentage by weight:
the preparation method of the acne-removing scar-removing composition comprises the following steps:
s1: heating pure water to 80 ℃ and keeping the temperature constant;
s2: adding asiaticoside and Saviae Miltiorrhizae radix extract into purified water in S1, and stirring at rotation speed of 240r/min for 20 min to obtain a first mixture;
s3: adding radix Sophorae Flavescentis extract and baicalin into the first mixture, and stirring at 240r/min for 20 min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 10 minutes at the rotating speed of 240r/min, and then filtering by using a 550-mesh filter cloth to obtain the acne-removing and scar-removing composition.
Application example 1
The acne and scar removing composition prepared in the example 1 is added to a mask only containing water according to the weight percentage of 5%, and the acne and scar removing mask is obtained.
Application example 2
The acne and scar removing composition prepared in the example 2 is added to the facial mask only containing water according to the weight percentage of 8%, and the acne and scar removing facial mask is obtained.
Application example 3
The acne and scar removing composition prepared in the example 3 is added into a mask only containing water according to the weight percentage of 10 percent, and the acne and scar removing mask is obtained.
Application example 4
The acne and scar removing composition prepared in the example 4 is added into a mask only containing water according to the weight percentage of 10%, and the acne and scar removing mask is obtained.
Application example 5
The acne and scar removing composition prepared in example 5 is added to a mask only containing water according to the weight percentage of 10%, and the acne and scar removing mask is obtained.
Application example 6
The acne and scar removing composition prepared in example 6 is added to a mask only containing water according to the weight percentage of 10%, and the acne and scar removing mask is obtained.
Application example 7
The acne and scar removing composition prepared in example 7 is added to a mask only containing water according to the weight percentage of 10%, and the acne and scar removing mask is obtained.
Performance test
Activating the freeze-stored Propionibacterium acnes, and diluting the bacterial liquid to 1.0 × 106And CFU/mL, adding 1mL of diluted bacterial liquid into a 24-pore plate per hole, simultaneously adding 1mL of the acne-removing scar-removing composition prepared in the embodiment 1-7 and three holes of pure water, placing the 24-pore plate in an anaerobic box, incubating for 48 hours, taking out, and detecting OD600 of each hole by using an enzyme labeling instrument to obtain the bacteriostatic rate of the propionibacterium acnes. As shown in table 2:
the acne-removing scar-removing facial masks obtained in application examples 1-7 are used as experimental groups 1-7, and facial masks only containing pure water are used as comforting groups. 160 volunteers aged 15-30 years and having pox of different degrees were recruited and randomly divided into 8 groups of 20 persons each. The first group is volunteers using a placebo group, the second group to the eighth group are volunteers using experiment groups 1-7 respectively, each group of volunteers is used once per night and continuously used for 10 days, the volunteers score according to observation and photographing contrast, the scoring standard is 10 points, 1 point is the worst, 10 points are the best, and the higher the score is, the better the effect is. The test results are shown in table 3:
the above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention.
Claims (10)
1. The acne-removing scar-removing composition is characterized by comprising the following components in percentage by weight:
2. the composition for removing acne and scars according to claim 1, wherein:
the composition also comprises 0.5-5 wt% of baicalin.
3. The composition for removing acne and scars according to claim 1, wherein:
the total asiaticoside accounts for 3-10 wt%.
4. The composition for removing acne and scars according to claim 1, wherein:
the weight percentage of the salvia miltiorrhiza extract is 1-3%.
5. The composition for removing acne and scars according to claim 1, wherein:
the weight percentage of the sophora flavescens extract is 2-5%.
6. An acne and scar removing composition according to any one of claims 1 to 5, wherein:
the humectant is butanediol.
7. The composition for removing acne and scars according to any one of claim 6, wherein:
the asiaticoside is obtained by decocting centella asiatica with water, adsorbing with silica gel column, eluting, collecting eluate, concentrating, and drying.
8. A method for preparing an acne and scar removing composition according to any one of claims 1 to 7, comprising the following steps:
s1: heating pure water to 70-90 ℃ and keeping the temperature constant;
s2: adding the asiaticoside and the salvia miltiorrhiza extract into pure water in S1, and stirring for 15-25 minutes at the rotating speed of 200-250r/min to obtain a first mixture;
s3: adding the sophora flavescens extract and baicalin into the first mixture, and stirring for 15-25 minutes at the rotating speed of 200-250r/min to obtain a second mixture;
s4: and adding butanediol into the mixture II, stirring for 8-12 minutes at the rotating speed of 200-250r/min, and then filtering by using filter cloth with 500-600 meshes to obtain the acne-removing and scar-removing composition.
9. Use of an acne and scar removing composition according to any of claims 1 to 7,
the acne-removing scar-removing composition is added into a face water, a facial mask, a gel or an essence.
10. The composition for removing acne and scar according to claim 9, wherein,
the acne-removing scar-removing composition is added into beauty water, a facial mask, gel or essence in a weight percentage of 5-10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111617128.9A CN114209626A (en) | 2021-12-27 | 2021-12-27 | Acne-removing scar-removing composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111617128.9A CN114209626A (en) | 2021-12-27 | 2021-12-27 | Acne-removing scar-removing composition and preparation method and application thereof |
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| Publication Number | Publication Date |
|---|---|
| CN114209626A true CN114209626A (en) | 2022-03-22 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202111617128.9A Pending CN114209626A (en) | 2021-12-27 | 2021-12-27 | Acne-removing scar-removing composition and preparation method and application thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870131A (en) * | 2021-03-31 | 2021-06-01 | 深圳市萱嘉生物科技有限公司 | Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof |
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- 2021-12-27 CN CN202111617128.9A patent/CN114209626A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112870131A (en) * | 2021-03-31 | 2021-06-01 | 深圳市萱嘉生物科技有限公司 | Traditional Chinese medicine extract composition with acne removing effect and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 石宇等: "中药在皮肤美容中的应用研究进展", 《中国美容医学》 * |
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