CN110613823A - Traditional Chinese medicine composition for treating beriberi and bromhidrosis, preparation method thereof and medicine containing traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for treating beriberi and bromhidrosis, preparation method thereof and medicine containing traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating beriberi and bromhidrosis, a preparation method thereof and a medicine containing the same. The traditional Chinese medicine composition comprises argy wormwood oil, peppermint oil, zedoary turmeric oil, pomelo oil, menthol and lavender oil. The traditional Chinese medicine composition is externally applied to the affected part, so that beriberi and bromhidrosis can be effectively treated, sweating is reduced, bacteria and fungi are killed, and bacteria can be durably inhibited, so that peculiar smell can be eliminated, and the traditional Chinese medicine composition is free from stimulation to skin. In addition, the preparation method provided by the invention is simple in process, easy to implement and beneficial to large-scale production and implementation. Moreover, the medicine containing the traditional Chinese medicine composition can be prepared into any externally-applied preparation formulation acceptable in medicine for treating beriberi and bromhidrosis.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating beriberi and bromhidrosis, a preparation method thereof, and a medicine containing the same.
Background
Dermatophytosis, also known as tinea pedis, is a foot dermatosis caused by fungal infection, which causes foot erosion, blisters or squash corners and the like, and generates peculiar smell or odor. The sweat gland of the skin of the foot of a person is rich, the sweat gland is more sweaty, the sweat contains moisture, salt, lactic acid, urea and the like, and the air circulation is poor, and the local part is moist and warm, so that an environment suitable for growth of filamentous fungi is generated, and mass propagation of the fungi is promoted. In addition, the skin stratum corneum of the sole part is thicker, and keratin in the stratum corneum is rich in nutrients of fungi and is further beneficial to the growth of the fungi. Various products of the decomposition of sweat and keratin can produce various off-flavors or odors.
At present, fungi inhibiting medicines are adopted for treating beriberi, most of the medicines belong to chemical hormone medicines, and can only temporarily inhibit bacteria and relieve itching to cause the false impression of improvement of beriberi, but the symptoms are treated, the root cause is not treated, beriberi can be relapsed after stopping the medicines for a period of time, dependence and side effects are easy to generate on the medicines after long-time use, and pathogenic bacteria can also generate drug resistance on the medicines.
Bromhidrosis, also known as bromhidrosis, hyperhidrosis, and bromhidrosis, is a special unpleasant odor caused by secretion of apocrine gland (apocrine gland) distributed on the surface of skin, such as underarm, perineum, and upper back. The secretion of the apocrine sweat gland contains protein, lipid, glucose and other components, has no smell immediately after secretion, and is decomposed by bacteria after being discharged to the skin surface to generate decomposition products such as unsaturated fatty acid, aldehyde, ketone and the like, thereby emitting peculiar smell. The abundant apocrine glands in the armpit are the most major sites for the generation of the odor. The bromhidrosis can seriously affect interpersonal interaction due to the odor emitted by the bromhidrosis, so that great psychological stress is caused, and daily life and work are affected. The apocrine sweat gland is exuberant in puberty, so that the apocrine sweat gland is mostly seen in young and strong years, the apocrine sweat gland is gradually degenerated and the symptoms can be relieved or disappeared along with the aging of a human body, and the elderly patients with bromhidrosis rarely have family genetic history, and most of the patients have family genetic history.
Regarding the treatment of bromhidrosis, no thorough radical treatment method is found at present, symptomatic treatment is usually carried out but not caused treatment, the treatment comprises external medicine rubbing, A type botulinum toxin injection, laser burning, operation removal of apocrine sweat gland and the like, the methods cannot completely ensure the curative effect, and the defects of incomplete treatment, easy relapse, great damage to the body and the like exist.
The emergence of a drug that is effective in treating both of these diseases is currently in great demand.
Disclosure of Invention
[ problem ] to
Aiming at the defects in the prior art, the invention aims to provide the traditional Chinese medicine composition for treating beriberi and bromhidrosis, which is externally applied to an affected part, can effectively treat the beriberi and the bromhidrosis, reduces sweating, kills bacteria and fungi, can inhibit bacteria for a long time, can eliminate peculiar smell and has no stimulation to skin.
The invention also aims to provide a preparation method of the traditional Chinese medicine composition, which has simple process and easy execution and is beneficial to large-scale production and implementation.
The invention also aims to provide a medicine for treating beriberi and bromhidrosis, which comprises the traditional Chinese medicine composition and medically acceptable auxiliary materials.
[ solution ]
In order to achieve the above objects, one aspect of the present invention provides a Chinese medicinal composition for treating beriberi and body odor, which comprises:
in the above Chinese medicinal composition, the oleum Artemisiae Argyi, also called oleum Artemisiae Argyi, is volatile oil of folium Artemisiae Argyi, and is obtained by steam distillation of folium Artemisiae Argyi. Folium Artemisiae Argyi is dried leaf of Artemisia argyi Levl. et Vant.L.of Compositae, picked in summer when flowers are not bloomed, removed of impurities, and dried in the sun. It is pungent, bitter, warm and slightly toxic; it enters liver, spleen and kidney meridians. The argy wormwood leaves have the effects of warming channels, stopping bleeding, dispelling cold, relieving pain, externally clearing damp and relieving itching, and the argy wormwood oil prepared from the argy wormwood leaves has obvious broad-spectrum killing or inhibiting effects on common bacteria and fungi on epidermis, and has the effects of resisting inflammation and allergy. Preferably, in the traditional Chinese medicine composition of the present invention, the content of the moxa oil may be 20 to 50 parts by weight, preferably 22 to 48 parts by weight, 24 to 46 parts by weight, 26 to 44 parts by weight, 28 to 42 parts by weight, 30 to 40 parts by weight, 32 to 38 parts by weight, 34 to 36 parts by weight, or 35 parts by weight. Within the above range, the moxa oil can not only kill bacteria and fungi, but also inhibit the growth of bacteria and fungi for a long time.
Peppermint oil, also known as dementholized peppermint oil, is volatile oil extracted from fresh stems and leaves of Mentha haplocalyx Briq of Labiatae by steam distillation, cooling, and partial dehydration. The peppermint oil is colorless or light grass green and light yellow clear liquid, has special cool fragrance, is pungent at the beginning and cool at the end, has strong peppermint fragrance and cool slightly bitter taste, and has strong channeling performance; the liquid can be solidified into solid when cooled slightly, and the color becomes dark gradually after the liquid is stored for a long time. The peppermint oil has the effects of dispelling wind, clearing heat, clearing head and eyes, relieving sore throat, promoting eruption, soothing liver, promoting qi circulation and relieving itching, and also has a good bactericidal effect; it has effects in contracting blood capillary, relieving eczema, tinea, itching, inflammation and burn, and softening skin. Preferably, in the traditional Chinese medicine composition of the present invention, the content of the peppermint oil may be 20 to 50 parts by weight, preferably 22 to 48 parts by weight, 24 to 46 parts by weight, 26 to 44 parts by weight, 28 to 42 parts by weight, 30 to 40 parts by weight, 32 to 38 parts by weight, 34 to 36 parts by weight, or 35 parts by weight. Within the above range, the peppermint oil can effectively sterilize and relieve itching, and can also freshen, improve and suppress body odor.
Zedoary turmeric oil, volatile oil extracted from Curcumae rhizoma (Curcuma wenyujin) by steam distillation, which is light brown or dark brown clear liquid; peculiar smell, slightly bitter and pungent taste. The Curcumae rhizoma is dried rhizome of Curcuma zedoaria (Curcuma phaeocaulis Val.) or Curcuma wenyujin (Curcuma kwangsiensis S.G.Lee et C.F.Liang) or Curcuma wenyujin (Curcuma wenyujin Y.H.Chen et C.Ling) of Zingiberaceae, which is harvested after withering in winter, cleaned, steamed or boiled to be transparent, and dried in the sun or at low temperature to remove fibrous root and impurities. Rhizoma Curcumae has effects of activating qi-flowing, relieving pain, resolving hard mass, removing blood stasis, resolving stagnation, dredging channels, and removing abdominal mass and stagnation. Zedoary turmeric oil prepared from Curcumae rhizoma is mainly used for treating stagnation of qi and blood, heart and abdominal distention and pain, abdominal mass, accumulation, indigestion, blood stasis amenorrhea, and pain caused by traumatic injury; in addition, it has antibacterial and antifungal, antiinflammatory, and keratinocyte hyperplasia inhibiting effects. Preferably, in the traditional Chinese medicine composition of the present invention, the content of the zedoary turmeric oil may be 5 to 30 parts by weight, preferably 7 to 28 parts by weight, 9 to 26 parts by weight, 11 to 24 parts by weight, 13 to 22 parts by weight, 15 to 20 parts by weight, or 17 to 18 parts by weight. Within the range, the zedoary turmeric oil can effectively kill bacteria and fungi, diminish inflammation, reduce perspiration and the like.
The pomelo oil is also called camellia oil, tea seed oil and camellia seed oil, and is an oil material prepared by physically squeezing seeds of camellia trees. Camellia oleifera (Camellia oleifera Abel.) is a plant of the genus Camellia in the family Theaceae, grows in mountains and hilly areas in subtropical areas in southern China, and is mainly concentrated in Zhejiang, Jiangxi, Henan, Hunan, and Guangxi provinces. The pomelo oil contains tea polyphenol, tea saponin, higher unsaturated fatty acid, active polysaccharide, amino acid and the like, wherein the tea polyphenol is an excellent natural antioxidant and has the functions of detoxification and radiation resistance; the tea saponin is natural nonionic surfactant, has pharmacological functions of relieving pain, diminishing inflammation, eliminating phlegm, resisting osmosis, clearing away heat and toxic materials, relieving itching, sterilizing, etc., and has good killing and inhibiting properties on various bacteria and fungi. Preferably, in the traditional Chinese medicine composition of the present invention, the content of the grapefruit oil may be 5 to 30 parts by weight, preferably 7 to 28 parts by weight, 9 to 26 parts by weight, 11 to 24 parts by weight, 13 to 22 parts by weight, 15 to 20 parts by weight, or 17 to 18 parts by weight. Within the above range, the grapefruit oil is effective in killing bacteria and fungi, and promoting absorption of the Chinese medicinal composition into the skin, and the like.
Menthol, a saturated cyclic alcohol, having the chemical name 5-methyl-2- (1-methylethyl) cyclohexanol, molecular formula C10H20O, colorless acicular or prismatic crystals or white crystalline powder, has the special fragrance of mint, and is cool after being burnt at the beginning of taste. The menthol can act on sensory nerve endings of the skin to generate cool feeling on the surface of the skin so as to achieve the aim of relieving itching, and the menthol is light in weight, fragrant and capable of promoting the circulation of qi and blood, and is good at dispersing the wind heat in upper jiao. Preferably, in the traditional Chinese medicine composition of the present invention, the content of the menthol may be 0.1 to 10 parts by weight, preferably 0.5 to 9.5 parts by weight, 1.0 to 9.0 parts by weight, 1.5 to 8.5 parts by weight, 2.0 to 8.0 parts by weight, 2.5 to 7.5 parts by weight, 3.0 to 7.0 parts by weight, 3.5 to 6.5 parts by weight, 4.0 to 6.0 parts by weight, 4.5 to 5.5 parts by weight, or 5.0 parts by weight. Within the range, the menthol can sterilize and relieve itching, and can ensure that the traditional Chinese medicine composition can take effect deeply under the skin, and the like.
The lavender oil is volatile oil extracted from leaf, stem and flower of Lavender by steam distillation. Lavender (Lavandula angustifolia Mill.) also known as perfume plant, Lysimachia foenum-graecum, Vanilla officinalis, herba Lysimachiae Foenumgraeci, and Lavender is a shrub of Lavandula of Dicotyledoneae. The lavender oil mainly comprises borneol, cage for animals geraniol, geranyl ester, lavender ester, linalool, limonene, clove oil hydrocarbon, coumarin, terpinee and the like, has the effects of reducing pressure, tranquilizing, diminishing inflammation, sterilizing, preventing and treating mosquito bites and the like, and also has the effects of balancing oil secretion, promoting telangiectasis, increasing blood flow, promoting cell growth and wound healing, removing scars and the like. Preferably, in the traditional Chinese medicine composition of the present invention, the lavender oil may be contained in an amount of 0.1 to 10 parts by weight, preferably 0.5 to 9.5 parts by weight, 1.0 to 9.0 parts by weight, 1.5 to 8.5 parts by weight, 2.0 to 8.0 parts by weight, 2.5 to 7.5 parts by weight, 3.0 to 7.0 parts by weight, 3.5 to 6.5 parts by weight, 4.0 to 6.0 parts by weight, 4.5 to 5.5 parts by weight, or 5.0 parts by weight. Within the range, the lavender oil can be used for calming the skin, relieving itching, diminishing inflammation, sterilizing, reducing sweat discharge and the like.
In addition, in the traditional Chinese medicine composition, the pomelo oil, the menthol and the lavender oil can increase subcutaneous microcirculation of feet and armpits, promote the absorption of skin to medicines, and can also act on apocrine sweat glands to inhibit the secretion of protein, lipid and the like, so that the source of peculiar smell generation is reduced from the source; the blumea oil, the peppermint oil and the zedoary turmeric oil are matched with each other, so that the capability of killing bacteria and fungi is further improved, the bacteriostatic ability is maintained for a long time, and the blumea oil, the menthol and the lavender oil can further penetrate into gaps and subcutaneous parts of the skin under the action of the shaddock oil, the menthol and the lavender oil to reach the dermis layer, so that the bacteria and the fungi hidden and remained under the skin are powerfully swept away, no dead angle is left, the lasting bacteriostatic effect can be kept on the surface and the subcutaneous parts of the skin, and the cure and consolidation of the bromhidrosis or the beriberi are ensured; the pomelo oil and the lavender oil are matched with each other, and can reduce sweat gland perspiration, so that the skin is kept dry, and bacteria and fungi are prevented from breeding. In addition, the traditional Chinese medicine composition adopts mild components, not only does not irritate skin due to deep subcutaneous penetration, but also has the effects of resisting inflammation and reducing histamine generation.
Further, the Chinese medicinal composition for treating beriberi and body odor according to the present invention comprises:
preferably, the Chinese medicinal composition for treating beriberi and body odor according to the present invention comprises:
within the range, the traditional Chinese medicine composition can better reduce the secretion of apocrine sweat glands, kill bacteria and fungi for a long time and effectively treat beriberi and bromhidrosis.
Another aspect of the present invention provides a preparation method of the above-mentioned traditional Chinese medicine composition, which comprises the following steps:
(1) dissolving Mentholum in oleum Menthae Dementholatum, adding oleum Lavandula Angustifolia, zedoary turmeric oil and fructus Citri Grandis oil, and mixing;
(2) diluting the blumea oil with 60-80% ethanol water solution by volume, and uniformly mixing with the mixture in the step (1).
Preferably, in the above step (2), the weight ratio of the moxa oil to the ethanol aqueous solution may be 1:5 to 5:1, preferably 1:2 to 2:1, or 1: 1. The volume ratio of the ethanol aqueous solution is preferably 70%.
In addition, the invention also provides a medicine for treating beriberi and bromhidrosis, which comprises the traditional Chinese medicine composition and medically acceptable auxiliary materials.
The dosage form of the medicament may be any one of medically acceptable external dosage forms such as tinctures, liniments, paints, coating agents, films, lotions, pastes, creams, ointments, sprays, aerosols, gels, plasters, patches and emplastrums, but the invention is not limited thereto.
[ advantageous effects ]
In conclusion, the invention has the following beneficial effects:
the traditional Chinese medicine composition can effectively treat beriberi and bromhidrosis, penetrates into the subcutaneous part of an affected part, effectively reduces sweat gland perspiration and apocrine gland secretion, and continuously kills bacteria and fungi, so that peculiar smell can be eliminated, and the beriberi and the bromhidrosis can be eradicated. In addition, the traditional Chinese medicine composition disclosed by the invention adopts volatile oil extracted from natural plants as a component, does not contain any dangerous chemical component, does not have adverse effect on a human body, and is safe and effective.
In addition, the preparation method provided by the invention is simple in process, easy to implement and beneficial to large-scale production and implementation.
Detailed Description
The present invention will be described in further detail with reference to examples.
Source of raw materials
Moxa oil, purchased from Weihai medicinal oil works in Jishui county, Jiangxi;
peppermint oil, purchased from Weihai medicinal oil works in Jishui county, Jiangxi;
zedoary turmeric oil, available from Jiangxi Ji' an red apple natural flavor oil Co., Ltd;
pomelo oil, available from Hainan Shanlilang Camellia oil Co., Ltd;
menthol, purchased from Weihai medicinal oil works in Jishui county, Jiangxi;
lavender oil, available from Jiangxi Ji' an red apple Natural flavors, Inc.
< example >
Example 1
(1) Dissolving 0.5g of menthol in 3.5g of peppermint oil, adding 0.5g of lavender oil, 1.75g of zedoary turmeric oil and 1.75g of pomelo oil, and uniformly mixing; and
(2) diluting 3.5g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 2
(1) Dissolving 0.3g of menthol in 3.0g of peppermint oil, adding 0.7g of lavender oil, 2.4g of zedoary turmeric oil and 1.1g of pomelo oil, and uniformly mixing; and
(2) diluting 3.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 3
(1) Dissolving 0.7g of menthol in 4.0g of peppermint oil, adding 0.3g of lavender oil, 1.1g of zedoary turmeric oil and 2.4g of pomelo oil, and uniformly mixing; and
(2) diluting 4.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 4
(1) Dissolving 0.3g of menthol in 4.0g of peppermint oil, adding 0.3g of lavender oil, 2.4g of zedoary turmeric oil and 2.4g of pomelo oil, and uniformly mixing; and
(2) diluting 3.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 5
(1) Dissolving 0.01g of menthol in 2.0g of peppermint oil, adding 1.0g of lavender oil, 0.5g of zedoary turmeric oil and 3.0g of pomelo oil, and uniformly mixing; and
(2) diluting 5.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 6
(1) Dissolving 1.0g of menthol in 5.0g of peppermint oil, adding 0.01g of lavender oil, 3.0g of zedoary turmeric oil and 0.5g of pomelo oil, and uniformly mixing; and
(2) diluting 2.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 7
(1) Dissolving 1.0g of menthol in 2.0g of peppermint oil, adding 1.0g of lavender oil, 3.0g of zedoary turmeric oil and 3.0g of pomelo oil, and uniformly mixing; and
(2) diluting 2.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
Example 8
(1) Dissolving 0.01g of menthol in 5.0g of peppermint oil, adding 0.01g of lavender oil, 0.5g of zedoary turmeric oil and 0.5g of pomelo oil, and uniformly mixing; and
(2) diluting 5.0g of blumea oil with 3.5g of 70% ethanol water solution according to volume ratio, and uniformly mixing with the mixture obtained in the step (1) to obtain the traditional Chinese medicine composition.
< Experimental example >
Experimental example 1: evaluation of therapeutic Effect on beriberi
1. Patient treatment efficacy testing
The method comprises the steps of selecting 40 patients suffering from erosive type beriberi, blister type beriberi and scale angle type beriberi (120 patients in total, unlimited in nature, and age between 10 and 70 years), dividing the patients into eight groups with the same number of people (each group comprises 5 patients suffering from erosive type beriberi, blister type beriberi and scale angle type beriberi, 15 patients in total), cleaning feet at night, coating the parts, with the traditional Chinese medicine composition prepared according to embodiments 1 to 8 of the invention, on the affected skin of the feet, and continuously coating for 7 days to form 1 treatment course.
The number of people who adopt the traditional Chinese medicine composition to obtain the corresponding curative effect is counted by adopting the following judgment standards: the clinical signs of symptoms substantially disappeared, the amount of perspiration on the foot decreased, and the skin tone of the cuticle on the foot substantially returned to normal. The number of patients who had no treatment on day 7 and who had no recurrence of beriberi after continuing to stop the medication for 15 days was counted, and the results are shown in table 1 below.
[ Table 1]
| The number of patients who obtained therapeutic effect at the time of drug withdrawal on day 7 | The number of people who have no recurrence of beriberi after continuing to stop taking medicine for 15 days | |
| Example 1 | 15 | 15 |
| Example 2 | 15 | 14 |
| Example 3 | 15 | 14 |
| Example 4 | 15 | 13 |
| Example 5 | 13 | 12 |
| Example 6 | 14 | 13 |
| Example 7 | 12 | 12 |
| Example 8 | 13 | 12 |
As can be seen from table 1, the Chinese medicinal compositions prepared according to examples 1 to 8 of the present invention have very good therapeutic effects on various beriberi, and also have long-term efficacy of inhibiting recurrence after drug withdrawal, so that a cure rate of 80% or more can be achieved.
2. In vitro fungal examination
(1) The result of the microscopic examination is that,
respectively extracting a small amount of scurf at the diseased position of the patient before the patient is coated with the traditional Chinese medicine composition, when the patient stops the medicine on the 7 th day and after the patient continues stopping the medicine for 15 days, and observing by using a fungal microscopic examination to find that hypha and spores are positive.
The microscopic examination result shows that a large amount of fungal hyphae and spores are found in the examined materials of patients before treatment, so that the beriberi is caused by the mass propagation of the fungi; in contrast, according to the results shown in table 1, the samples from patients who had the corresponding therapeutic effects showed no presence of hyphae or spores both immediately after stopping the drug and after continuing to stop the drug for 15 days, while the samples from patients who had no therapeutic effects and had recurred showed a small amount of hyphae and/or spores, indicating that no complete cure was obtained, but the growth and proliferation of the fungi were also inhibited to some extent.
(2) Culture of fungi
Extracting a small amount of scurf at the diseased position of the patient after stopping the medicine on the 7 th day and continuing stopping the medicine for 15 days respectively, adding 70% ethanol for soaking for 2-3 minutes to kill other mixed bacteria, then inoculating the mixture onto a sand protection culture medium containing antibiotics, culturing for 48 hours in a constant temperature box at 37 ℃, and observing whether fungal colonies are generated.
The culture results showed that, according to the results in table 1, fungal colonies did not successfully grow in the petri dishes of the test materials immediately after the patient who had received the corresponding therapeutic effect was inoculated and after the patient continuously stopped the drug for 15 days, and fungal colonies grew in the petri dishes of the test materials of the patient who had received no therapeutic effect and had relapsed, indicating that cure was not completely obtained.
In addition, 20g of the Chinese medicinal composition according to embodiments 1 to 8 of the present invention can be added into 2L of warm water of 35 to 50 ℃ to soak feet for more than 20 minutes to treat beriberi, and similar effects to the above can be obtained, which will not be described herein again.
Experimental example 2: evaluation of therapeutic Effect of bromhidrosis
A total of 120 patients suffering from bromhidrosis (with unlimited nature and age between 10 and 70 years) are selected and divided into eight groups with equal number of people (15 people in each group), and after the armpits on both sides are cleaned every day, the underarm skin is coated with the traditional Chinese medicine composition prepared according to the embodiments 1 to 8 of the invention respectively, and the treatment course is 1 treatment course for 15 days continuously.
The number of people who adopt the traditional Chinese medicine composition to obtain the corresponding curative effect is counted by adopting the following judgment standards: the treated patients were allowed to sit still at room temperature of 25 ℃ for 15 minutes, and then two judges were allowed to approach the patients from both sides to their armpits, and no unpleasant body odor was smelled within 5 cm. The number of patients who obtained therapeutic effect when they were stopped on day 15 and the number of patients who had no recurrence of bromhidrosis after continuing to stop the medication for 60 days were counted, and the results are shown in table 2 below.
[ Table 2]
| The number of patients who obtain therapeutic effect after stopping taking the medicine on day 15 | The number of people who have no recurrence of body odor after continuing to stop taking medicine for 60 days | |
| Example 1 | 15 | 15 |
| Example 2 | 14 | 14 |
| Example 3 | 15 | 14 |
| Examples4 | 13 | 12 |
| Example 5 | 13 | 13 |
| Example 6 | 12 | 12 |
| Example 7 | 15 | 14 |
| Example 8 | 14 | 12 |
As can be seen from table 2, the Chinese medicinal compositions prepared according to examples 1 to 8 of the present invention all have very good therapeutic effects on body odor, and also have long-term efficacy of inhibiting recurrence after drug withdrawal, thereby achieving a cure rate of 80% or more.
The present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications of the present embodiment without inventive contribution as needed after reading the present specification, but all of them are protected by patent law within the scope of the claims of the present invention.
Claims (8)
1. A traditional Chinese medicine composition for treating beriberi and bromhidrosis is characterized by comprising the following components:
2. the traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises:
3. the traditional Chinese medicine composition of claim 1, wherein the traditional Chinese medicine composition comprises:
4. a method for preparing the traditional Chinese medicine composition of any one of claims 1 to 3, which is characterized by comprising the following steps:
(1) dissolving Mentholum in oleum Menthae Dementholatum, adding oleum Lavandula Angustifolia, zedoary turmeric oil and fructus Citri Grandis oil, and mixing;
(2) diluting the blumea oil with 60-80% ethanol water solution by volume, and uniformly mixing with the mixture in the step (1).
5. The method according to claim 4, wherein in the step (2), the weight ratio of the moxa oil to the ethanol aqueous solution is 1:5 to 5: 1.
6. The method according to claim 4, wherein the ethanol aqueous solution is 70% by volume in the step (2).
7. A medicament for treating beriberi and bromhidrosis, which comprises the traditional Chinese medicine composition of any one of claims 1 to 3 or the traditional Chinese medicine composition prepared by the preparation method of any one of claims 4 to 6, and medically acceptable auxiliary materials.
8. The medicament of claim 7, wherein the medicament is in a form selected from any one of tincture, liniment, plastics, film, lotion, paste, cream, ointment, spray, aerosol, gel, plaster, patch and emplastrum.
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