KR100708552B1 - Cosmetic composition for acne skin containing specific complex plant extract - Google Patents
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Abstract
본 발명은 종래의 화장료 조성물에 인체에 안전한 황백, 황련, 승마, 방풍, 백급 등으로부터 얻은 복합식물추출물을 배합한 것으로서 여드름 유발균인 백색 포도구균 및 여드름 병산간균의 생육을 억제함으로써 여드름 피부에 유효한 효과를 갖는 특정의 복합식물추출물을 함유하는 여드름 피부용 화장료 조성물에 관한 것이다. The present invention is a composite cosmetic extract obtained from sulfuric acid, yellow lotus, horse riding, windproof, weight, etc., which is safe for the human body to a conventional cosmetic composition, and is effective for acne skin by inhibiting the growth of acne-causing white staphylococcus and acne bacilli. It relates to a cosmetic composition for acne skin containing a specific complex plant extract having an effect.
본 발명은 종래의 화장료 조성물에, 여드름 유발균인 여드름 병산간균과 백색 포도구균에 대해 강력한 항균 효과를 가지면서도 장기간 사용시 인체 안전성이 높은 식물인 황백, 황련, 승마, 방풍, 백급 등 특정의 약재를 건조 중량 기준으로 일정 비율로 배합하여 용매로 추출, 얻은 복합식물추출물을 화장료 제형에 따라 일정량 함유하는 것으로 구성된 것이다.The present invention is a conventional cosmetic composition, having a strong antibacterial effect against acne-causing bacillus and white staphylococcus acne-causing bacteria, but a certain medicinal herbs, such as sulfur white, yellow lotus, horse riding, windproof, weight, which is a plant with high human safety after long-term use It is composed of containing a certain amount of the composite plant extract, which is extracted and mixed with a solvent by mixing in a predetermined ratio on a dry weight basis, according to the cosmetic formulation.
이상과 같은 본 발명에 의한 화장료 조성물의 효과를 임상적으로 측정한 결과, 특정의 복합식물추출물을 함유하는 여드름 피부용 화장료는 종래 처방의 화장료에 비해 여드름 피부에 대해 우수한 효과를 가진다.As a result of clinically measuring the effect of the cosmetic composition according to the present invention as described above, the cosmetic for acne skin containing a specific complex plant extract has an excellent effect on acne skin compared to the cosmetic of the conventional prescription.
여드름 피부, 황백, 황련, 백급, 승마, 방풍. Acne skin, yellowish white, yellow soot, platinum, horse riding, windproof.
Description
본 발명은 종래의 화장료 조성물에 인체에 안전한 황백, 황련, 승마, 방풍, 백급 등으로부터 얻은 복합식물추출물을 배합한 것으로서 여드름 유발균인 백색 포도구균 및 여드름 병산간균의 생육을 억제함으로써 여드름 피부에 유효한 효과를 갖는 특정의 복합식물추출물을 함유하는 여드름 피부용 화장료 조성물에 관한 것이다. The present invention is a composite cosmetic extract obtained from sulfuric acid, yellow lotus, horse riding, windproof, weight, etc., which is safe for the human body to a conventional cosmetic composition, and is effective for acne skin by inhibiting the growth of acne-causing white staphylococcus and acne bacilli. It relates to a cosmetic composition for acne skin containing a specific complex plant extract having an effect.
일반적으로, 여드름은 피지분비 과잉, 피부각질화 과잉 및 혐기성 피부상에 존재하는 균인 백색 포도구균과 여드름 병산간균에 의한 염증 진전에 그 원인이 있는 것으로 알려져 있다. 이러한 여드름을 치료하기 위해 피지 생성을 억제하는 항 안드로겐제, 항염제로 작용하는 비스테로이드 소염제, 그리고 항균효과가 있는 레조시놀, 유황 및 벤조일 퍼록사이드(Benzoyl peroxide)와 항생효과가 있는 테트라싸이클린(Tetracyclin), 에리스로마이신 및 매크로싸이클린 등에 의한 여드름 병산간균 등에 대한 활성 억제 방법 등이 있다. 최근에는 레티노익산(Retinoic acid) 등의 비타민A 유도체를 이용한 치료 방법도 많이 사용되고 있다. 또한 오래전부터 동양에서 약재로 사용되어 오던 몰약 등을 이용한 여드름에 유효한 화장료에 관한 기술도 소개된 바, 대한민국 특허공보 제95-8762호(이형재 등)에 소개되어 있다. 또한 공지의 프로폴리스(propolis)와 같은 항균성 천연추출물은 여러 가지 여드름의 종류 중 백색여드름(white comedo)이나 흑색여드름(black comedo) 등 비염증성 여드름의 발생 억제력은 없어서 여드름 치유력에 한계가 있다는 것은 공지의 사실이다. In general, acne is known to be responsible for the development of inflammation caused by excess sebum secretion, excess keratinization and anaerobic skin, Staphylococcus aureus and acne bacilli. To treat acne, anti-androgens that inhibit sebum production, non-steroidal anti-inflammatory drugs that act as anti-inflammatory agents, and antibacterial resorcinol, sulfur and benzoyl peroxide, and tetracycline with antibiotics , Erythromycin, macrocycline and the like for acne bacilli bactericidal activity. Recently, many therapeutic methods using vitamin A derivatives such as retinoic acid have been used. In addition, a technology related to cosmetics effective for acne using myrrh, which has been used as a medicinal herb for a long time, was introduced in Korea Patent Publication No. 95-8762 (Lee Jae-jae, etc.). In addition, it is known that antibacterial natural extracts such as propolis have a limited ability to cure acne because they do not inhibit the occurrence of non-inflammatory acne such as white acne or black comedo among various acne types. It is true.
이러한 방법들은 여드름 예방과 치료에 있어 어느 정도 성과를 거두고 있으나, 효과적인 측면이나 피부안전성 측면에 있어서 아직 몇 가지 문제점을 가지고 있다. 즉, 호르몬제의 사용은 표피의 성장억제나 기타 호르몬 남용 등의 역효과를 유발할 수 있다고 보고되고 있으며, 레티노익산과 벤조일 퍼록사이드 등은 피부의 자극성과 접촉성 피부염의 우려가, 테트라사이클린을 위시한 항생물질은 내균성의 발생과 광과민 작용의 가능성이 있다고 알려져 있다. 또한 몰약 등 종래의 동양 약재 식물추출물을 이용한 여드름에 유효한 화장료 조성물은 그 효능에 있어서 유효한 효과는 인정하나 민감성의 여드름 피부에 대해서는 경우에 따라 알레르기 과민반응을 보이는 경우도 있어 그 사용 범위가 다소 한정될 수 있는 문제점을 가지고 있다.While these methods have some results in acne prevention and treatment, there are still some problems in terms of effectiveness and skin safety. In other words, the use of hormones has been reported to cause adverse effects such as growth inhibition of the epidermis and other hormone abuse. Retinoic acid and benzoyl peroxide, such as antibiotics including tetracycline, may cause skin irritation and contact dermatitis. The substance is known to have the potential for bacterial resistance and photosensitization. In addition, cosmetic compositions effective for acne using conventional oriental herbal plant extracts, such as myrrh, are recognized as effective in their efficacy, but the sensitive acne skin may show an allergic reaction in some cases, so its use range may be limited. I have a problem.
본 발명은 이러한 상기 문제점을 고려하여 안출한 것으로 여드름의 원인으로 알려져 있는 여드름 병산간균 및 백색 포도구균에 대해 특이적인 항균작용을 가지 고 있으면서도 장기간 사용해도 인체 안전성이 높은 물질을 개발하기 위해 연구를 거듭한 결과, 한방 의학에서 사용되고 있는 몇 가지 항균성 식물추출물이 여드름에 대해 유효한 효과를 가지고 있는 것을 알게 되었다. 그리하여 이들 식물추출물을 종래의 화장료 조성물에 함유함으로써 여드름 피부에 유효한 효과를 갖는 화장료 조성물을 개발하게 된 바, 이를 본 발명의 실시예와 함께 상세히 설명하면 다음과 같다. The present invention has been devised in view of the above problems, and has repeatedly studied to develop a substance having a high level of human safety even though it has a specific antibacterial activity against acne bacilli and white staphylococci known as the cause of acne. As a result, some antimicrobial plant extracts used in herbal medicine have been found to have an effective effect on acne. Thus, by containing these plant extracts in the conventional cosmetic composition bar to develop a cosmetic composition having an effective effect on acne skin, which will be described in detail with an embodiment of the present invention as follows.
본 발명은 종래의 화장료 조성물에, 여드름 유발균인 여드름 병산간균과 백색 포도구균에 대해 강력한 항균 효과를 가지면서도 장기간 사용시 인체 안전성이 높은 식물인 황백, 황련, 승마, 방풍, 백급 등의 특정 부위 약재를 건조 중량 기준으로 일정 비율로 배합하여 용매로 추출, 얻은 복합식물추출물을 화장료 제형에 따라 일정량 함유하는 것으로 구성된 것이다.The present invention has a strong antibacterial effect against acne-causing bacillus and white staphylococcus acne-causing bacteria in the conventional cosmetic composition, but the specific part of the plant, such as yellowish white, yellow lotus, horse riding, windproof, white weight, which is a high human safety plant for long-term use. It is composed of containing a certain amount of the composite plant extract, which is extracted and extracted with a solvent by mixing in a predetermined ratio on a dry weight basis according to the cosmetic formulation.
본 발명에서 사용되는 식물들의 피부에 미치는 작용에 대해 알려진 사실을 기초로 간략히 설명하면 다음과 같다. Briefly described based on the known facts on the action of the plants used in the present invention as follows.
황백(黃柏)은 운향과(rutaceae)에 속하는 황벽나무의 껍질을 말린 것으로서 황경피라고도 한다. 낙엽활엽 교목으로 높이 10m 정도로 자라는데, 껍질에는 코르크가 발달했으며 속껍질은 황색이다. 하지 전후에 나무줄기에서 껍질을 벗겨내어 조피(粗皮:거친 껍질)를 제거하거나 썰어서 햇볕에 말린다. 이 껍질은 약으로 쓰이며 혈당저하 작용을 한다. 또한 폐렴쌍구균, 인형결핵균, 포도상구균 등에 대하여 발육저지 작용을 함과 동시에 종양세포의 번식을 저지시키고, 살균작용을 한다. Huangbaek (黃柏) is a bark of the bark of the yellow wall belonging to the rutaceae family, it is also called the hwanggyeongpi. It is a deciduous broad-leaved arboreous tree, growing up to 10m in height. Cork is developed in the bark, and the cuticle is yellow. Peel the bark from the trunk before or after the summer to remove the rough skin or cut it and dry it in the sun. This peel is used as a medicine to lower blood sugar. In addition, pneumococcal pneumoniae, pneumococcal tuberculosis, staphylococcus, etc., while inhibiting the development of tumor cells, and inhibits the growth and sterilization.
황련(黃連)은 쌍떡잎식물로서 미나리아재비 과의 상록 여러해살이풀이며, 학명은 Coptis chinensis이고 중국 원산이며 생약용으로 한국·일본·중국 등지에서 재배하기도 한다. 산지의 수림 그늘의 습진 땅에서 자란다. 땅속줄기는 굵고 옆으로 뻗으며 많은 수염뿌리가 나고 줄기 끝에 뿌리잎 4~5개가 나며 길이 10∼27cm이다. 잎은 세 장의 작은 잎이 나온 겹잎으로 작은 잎은 약간 굳고 톱니가 날카로우며 광택이 난다. 한방에서는 11월경에, 재식 5∼6년 된 황련·왜황련의 뿌리를 채취하여 햇볕에 말린 것을 황련이라 하며, 건위·진정·소염·항균 등의 효능이 있어 소화불량·위염·장염·복통·구토·이질·심계(心悸)·번열(煩熱)·정신불안·인후종통(咽喉腫痛)·토혈·코피·하혈·화상 등의 치료에 처방한다 Huanglian is a dicotyledonous plant, an evergreen perennial herb of the genus Minaria, and its scientific name is Coptis chinensis, is native to China, and is grown in Korea, Japan, and China for herbal medicine. It grows on eczema ground in the shade of forests in the mountains. Underground stem is thick and stretched to the side, with many beard roots, 4 ~ 5 root leaves at the end of stem, 10 ~ 27cm long. The leaf is a double leaf with three small leaves. The small leaf is slightly hardened, sharp and serrated. In oriental medicine, the roots of five to six years old Hwang-yeon and Dwarf-sea soybeans are harvested and dried in the sun.They are known as dry stomach, soothing, anti-inflammatory, and antibacterial, and have indigestion, gastritis, enteritis, stomach pain, It is prescribed for the treatment of vomiting, dysentery, heart system, severity, mental anxiety, sore throat, bleeding, nosebleeds, bleeding, and burns.
승마(升麻)는 쌍떡잎식물이며 미나리아재비 과의 여러해살이풀로서 학명은 Cimicifuga heracleifolia이고 끼멸가리라고도 한다. 깊은 산 숲 속에서 자란다. 높이 약 1m이다. 뿌리가 굵고 자줏빛을 띤 검은색이다. 잎은 어긋나고 잎자루가 길며 3개씩 1∼2회 갈라진다. 작은잎은 달걀 모양이고 흔히 2∼3개로 갈라지며 불규칙한 톱니가 있다. 한방에서 뿌리를 승마라고 하며 해열제와 해독제로 사용한다. 감기로 열이 많이 날 때 사용하면 땀이 나면서 열이 내린다. 대표적인 처방으로는 승마갈근탕과 청진탕이 있다. 한국, 중국 동북부, 우수리강에 분포한다.Horseback riding is a dicotyledonous plant, a perennial herb of the buttercup family, and its scientific name is Cimicifuga heracleifolia, also known as the pods. Grows in deep mountain forest. It is about 1m high. The roots are thick and purplish black. The leaves are alternate, the petiole is long, and split one by two three times. Small leaves are egg-shaped, often divided into two or three, with irregular sawtooth. The root is called horse riding in Korean medicine and is used as an antipyretic and antidote. If you use a lot of heat with a cold, you will sweat and get fever. Representative prescriptions include Riding Galgeum and Cheongjintang. It is distributed in Korea, northeastern China and Ussuri River.
방풍(防風)은 쌍떡잎식물이며 미나리과의 세해살이풀로서 학명은 Ledebouriella seseloides이고 건조한 모래흙으로 된 풀밭에서 자란다. 높이 약 1m이다. 가지가 많이 갈라진다. 종자에서 싹이 난 지 3년 만에 꽃이 피고 진다. 뿌리에서 많은 잎이 나온다. 줄기에 달린 잎은 어긋나며 잎자루는 위쪽으로 갈수록 짧 아지고 밑부분은 잎집으로 되고 3회 깃꼴로 갈라진다. 갈라진 조각은 줄 모양이며 끝이 뾰족하고 약간 딱딱하다. 중국 북동부, 화베이, 내몽골 원산이며 약용작물로 재배한다. 한방에서는 두해살이 뿌리를 감기와 두통, 발한과 거담에 약으로 쓴다. 대용품으로 갯기름나물·기름나물·갯방풍을 쓰기도 한다. 한국·중국·우수리강·몽골·시베리아 등지에 분포한다.Windproof is a dicotyledonous plant and is a perennial herbaceous plant named Ledebouriella seseloides and grows on dry sandy grasses. It is about 1m high. Branches diverge a lot. Flowers blossom and bloom three years after seeding. Many leaves come from the roots. The leaves on the stem are shifted, the petiole becomes shorter as it goes upward, and the lower part becomes the leaf leaf and splits into three pieces of feathers. Cracks are stripe-shaped and pointed and slightly hard. It is native to northeastern China, Huabei and Inner Mongolia, and is grown as a medicinal crop. In oriental medicine, two-year-old roots are used as medicine for colds, headaches, sweating, and expectoration. As a substitute, oil herb, oil herb, sea breeze may be used. It is distributed in Korea, China, Ussuri River, Mongolia, and Siberia.
백급은 외떡잎식물이며 난초과의 여러해살이풀로서 학명은 Bletilla striata이고 백급·주란·대암풀이라고도 한다. 양지 쪽에서 자란다. 높이 4cm로 육질이며 속은 흰색이다. 줄기는 단축되어 둥근 알뿌리로 되고 여기에서 5∼6개의 잎이 서로 감싸면서 줄기처럼 된다. 잎은 길이 20∼30cm, 나비 2∼5cm의 긴 타원형으로 끝이 뾰족하고 밑부분이 좁아져서 잎집처럼 되며 세로 주름이 많이 있다. 관상용으로 심는다. 한방에서는 덩이줄기를 백급이라고 하며 수렴제·지혈제·배농제(排膿劑)로서 상처와 위궤양 등에 사용한다. 중국에서는 가슴앓이·기침과 호홉곤란 치료에 사용하며, 또 점액질이 있어 풀을 만들기도 한다. 한국(전라남도), 일본, 타이완, 티벳 동부지역, 중국에 분포한다. Pangteum is a monocotyledonous plant and perennial herb of the family Orchidaceae, scientific name is Bletilla striata, and it is also known as Pangteum, Juran, and Daeamgrass. It grows on the sunny side. It is 4cm in height and meat is white. The stem is shortened to a round root, and 5-6 leaves are wrapped around each other to form a stem. The leaves are 20 ~ 30cm long, 2 ~ 5cm long oval, with pointed ends and narrowed bottoms, like leaves, with many vertical wrinkles. Plant for ornamental use. In oriental medicine, tubers are called baekryeum, astringents, hemostatic agents, drainage (배) is used for wounds and stomach ulcers. In China, it is used to treat heartburn, cough, and difficulty in hoping, and mucus makes grass. It is distributed in Korea (Jeollanam-do), Japan, Taiwan, eastern Tibet, and China.
본 발명에 사용되는 특정의 복합식물추출물을 제조하기 위한 식물들의 배합 중량비는 건조 약재 기준으로 다음과 같다. The blending weight ratio of the plants for producing a specific complex plant extract used in the present invention is as follows on a dry medicine basis.
황백(껍질); 60∼120g, 황련(뿌리); 60∼120g, 승마(뿌리); 60∼120g, 방풍(뿌리); 30∼60g, 백급(줄기); 30∼60g Yellowish white (shell); 60 to 120 g, yellow lotus (root); 60 to 120 g, horse riding (root); 60 to 120 g, windproof (root); 30 to 60 g, white (stem); 30-60 g
본 발명에 사용되는 식물들은 종래의 동결건조 방법으로 건조시키고 미세분말화한 후 추출한다. 본 발명에 사용되는 항균성 식물추출물을 제조하는데 이용되 는 추출 용매는 에탄올이나 여기에 프로필렌 글리콜(propylene glycol), 부틸렌 글리콜(butylene glycol) 등 폴리올(polyols)을 소량 가한 극성 용매 또는 그들과 정제수의 혼합 용액이며, 추출 방법은 종래의 방법을 이용하는 것이 가능한데, 예를 들면 건조된 식물 분말에 5∼10배량의 상기 추출 용매를 가하여 1∼7일간 실온에서 침적 추출하거나 1기압하 40∼60℃에서 1∼5시간 가온 추출하여 추출물을 얻는다.Plants used in the present invention are dried by a conventional lyophilization method, and then micropowdered and extracted. The extraction solvent used to prepare the antimicrobial plant extract used in the present invention is ethanol or a polar solvent obtained by adding a small amount of polyols such as propylene glycol, butylene glycol, or purified water thereof. It is a mixed solution, and the extraction method can use a conventional method, for example, 5-10 times the amount of the said extraction solvent is added to the dried plant powder, and it extracts by dipping at room temperature for 1-7 days, or at 40-60 degreeC under 1 atmosphere. The extract is obtained by heating for 1 to 5 hours.
본 발명에 있어서 여드름 피부용 화장료 조성물을 피부에 바르는 외용제의 형태로 하는 경우, 피부 외용제 중의 식물 추출물의 배합량은 전체의 0.05∼50.0 중량%, 특히 0.5∼10.0 중량%로 하는 것이 좋다.In the present invention, when the cosmetic composition for acne skin is used in the form of an external preparation applied to the skin, the blending amount of the plant extract in the external preparation for skin is preferably 0.05 to 50.0% by weight, particularly 0.5 to 10.0% by weight.
본 발명의 화장료 조성물은 상기(上記)한 복합식물추출물 외에도 필요에 따라 본 발명의 효과를 저하시키지 않는 범위내에서 피부 외용제에 일반적으로 사용하는 각종 성분, 예를 들면 수용성 성분, 분말 성분, 유분, 계면활성제, 보습제, 점도조절제, 방부제, 산화방지제, 향료, 색소, 천연추출물 등을 배합하는 것이 가능하다. 또한 종래의 여드름 치료제에 많이 사용되어온 벤조일 퍼록사이드(Benzoyl peroxide)나 테트라싸이클린(Tetracyclin), 에리스로마이신 등의 항균제나 항안드로겐, 스테로이드 등의 호르몬, 레티노익산(Retinoic acid) 등의 비타민A 유도체와 병용이 가능하다. The cosmetic composition of the present invention, in addition to the complex plant extracts described above, various components generally used in external preparations for skin, such as water-soluble components, powder components, oil, Surfactants, moisturizers, viscosity modifiers, preservatives, antioxidants, fragrances, colorants, natural extracts and the like can be blended. In addition, it can be used in combination with antibacterial agents such as benzoyl peroxide, Tetracyclin and erythromycin, hormones such as anti-androgens and steroids and vitamin A derivatives such as retinoic acid, which have been widely used in conventional acne treatments. It is possible.
본 발명의 화장료 조성물의 제형은 임의로 선택할 수 있으되,종래의 화장료 제형인 크림, 밀크로션, 유연화장수, 팩, 파운데이션 등 뿐만 아니라, 비누, 세안폼과 같은 세안료 등 여러 가지 형태로 제조할 수 있다.The formulation of the cosmetic composition of the present invention may be arbitrarily selected, but may be prepared in various forms such as face creams such as soap, face wash foam, as well as creams, milk lotions, soft cosmetics, packs, foundations, and the like, which are conventional cosmetic formulations. .
또한 본 발명에 사용되는 식물들은 오래전부터 동양에서는 민간 요법 또는 한방에서 사용해 오던 재료로서 피부 외용제로 사용시 인체에 대한 안전성이 확인되어 있어서,피부 및 점막에 대한 자극은 거의 없는 것으로 알려져 있다.In addition, the plants used in the present invention have been used for folk remedies or herbal medicine in the East for a long time has been confirmed as a safety to the human body when used as a skin external preparation, it is known that there is little irritation to the skin and mucous membranes.
본 발명의 항균성 식물추출물의 제조 방법을 실시예1을 통해 구체적으로 설명하면 다음과 같다.The antimicrobial plant extract of the present invention will be described in detail with reference to Example 1 as follows.
<실시예1> - 본 발명에 의한 특정의 복합식물추출물의 제조 방법Example 1 Method for Producing Specific Complex Plant Extract According to the Present Invention
황백 줄기(건조약재)를 분쇄한 것 100g, 황련을 분쇄한 것 100g , 승마를 분쇄한 것 100g, 방풍을 분쇄한 것 50g, 백급을 분쇄한 것 50g 등을 에탄올에 3,000㎖에 가하여 실온에서 10일간 침적하여 추출 여과한 후 그 여과액을 감압, 증발하여 240g의 농축물을 얻었다. 100 g of crushed yellow white stalks (dry medicinal herbs), 100 g of crushed yellow lotus, 100 g of horseradish crushed, 50 g of crushed windproof, 50 g of crushed whites, etc. After dipping and extracting and filtration for a day, the filtrate was evaporated under reduced pressure and 240g of concentrate was obtained.
또한 본 발명의 항균성 식물추출물을 함유하는 여드름 피부용 화장료 조성물을 화장품 제형별로 구체적인 처방예 1∼6을 통해 나타내면 아래와 같다. In addition, the cosmetic composition for acne skin containing the antimicrobial plant extract of the present invention is shown through specific prescription examples 1 to 6 for each cosmetic formulation as follows.
<처방예 1> - 크림(Cream)<Prescription 1>-Cream
<처방예 2> - 유연화장수(Skin Toner)<Prescription 2>-Skin Toner
<처방예 3> - 수렴 화장수(Astringent)<Prescription 3>-Astringent
<처방예 4> - 밀크 로션(Milk Lotion)<Prescription 4>-Milk Lotion
<처방예 5> - 유액상 파운데이션(Liquid Foundation)<Prescription 5>-Liquid Foundation
<처방예 6> - 비누(Soap)<Prescription 6>-Soap
이상과 같은 본 발명에 의한 항균성 식물추출물을 함유하는 화장료 조성물의 여드름 피부에 대한 치료 효과를 임상적으로 측정하기 위해 실시예1의 항균성 식물추출물을 함유하는 본 발명의 화장료 조성물(처방예1)과 종래 처방의 화장료 조성물(대조용)을 크림으로 각각 제조하여 여드름 보유자를 대상으로 임상 실험을 하였다. 즉, 비염증성 여드름을 가진 사람 10명과 염증성 여드름 중 발진성 여드름을 가진 사람 10명 및 화농성 여드름을 가진 사람 10명을 남녀 비율 15 : 15로 구성한 피실험자를 대상으로 상기 2가지 크림을 매일 2∼3회, 15일간 사용하면서 여드름 치료 상태를 육안으로 관찰하여 그 효과(발진 및 발열의 진정, 코메도(comedo) 형성의 감소, 화농 상태의 진정 또는 치료 등 전반적인 여드름 개선상태를 판정하여 표2와 같은 결과를 얻었다.In order to clinically measure the therapeutic effect on the acne skin of the cosmetic composition containing the antimicrobial plant extract according to the present invention as described above, the cosmetic composition (prescription example 1) of the present invention containing the antimicrobial plant extract of Example 1 and A cosmetic composition (control) of the conventional prescription was prepared in each cream and clinical trials were carried out for acne holders. In other words, two or three times the daily cream of the two creams for a subject consisting of a male and female ratio of 15: 15 to 10 people with non-inflammatory acne, 10 people with rash acne and 10 people with purulent acne among inflammatory acne , Acne treatment for 15 days with the naked eye to observe the effect (decreases the rash and fever, reduce the comedo (comedo) formation, soothing or treating the acne condition, etc.) Got it.
<표 2> - 여드름 치료 효과<Table 2>-Acne Treatment Effects
또한 본 발명에 의한 화장료 조성물의 여드름 치료 효과는 표2에 나타난 바와 같이 매우 양호한 것으로 판명되었다. 또한 이들 추출물은 여드름외에 일반 피부병을 유발하는 병원균들에 대해서도 생장 억제 효과가 있는 것으로 확인되었다. 이러한 모든 결과를 두고 볼 때, 본 발명에 의한 특정의 복합식물추출물을 함유하는 여드름 피부용 화장료는 종래 처방의 화장료에 비해 여드름 피부에 대해 우수한 효과를 가진다.In addition, the acne treatment effect of the cosmetic composition according to the present invention was found to be very good as shown in Table 2. In addition, these extracts have been shown to have a growth inhibitory effect on pathogens that cause general skin diseases in addition to acne. In view of all these results, the acne skin cosmetics containing the specific complex plant extract according to the present invention has an excellent effect on acne skin compared to the cosmetics of the conventional prescription.
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| CN107281066A (en) * | 2017-07-28 | 2017-10-24 | 刘怀 | Youth preserves youthful looks cream |
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| KR20050002581A (en) * | 2003-06-27 | 2005-01-07 | 신준식 | Cosmetic composition using a herb medicine |
| KR20050004354A (en) * | 2003-07-02 | 2005-01-12 | 나드리화장품주식회사 | Cosmetics composition containing herb medicine extracts and perfumes for preventing acne or inflammation |
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| US20150306024A1 (en) * | 2009-08-14 | 2015-10-29 | Amorepacific Corporation | Composition containing a natural extract |
| KR20160137044A (en) * | 2015-05-22 | 2016-11-30 | 주식회사 더삼점영 | A composition of plant extract for treating acne patients |
| CN107281066A (en) * | 2017-07-28 | 2017-10-24 | 刘怀 | Youth preserves youthful looks cream |
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