CN103357058A - Contact lenses care solution and preparation method thereof - Google Patents
Contact lenses care solution and preparation method thereof Download PDFInfo
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- CN103357058A CN103357058A CN2012100948679A CN201210094867A CN103357058A CN 103357058 A CN103357058 A CN 103357058A CN 2012100948679 A CN2012100948679 A CN 2012100948679A CN 201210094867 A CN201210094867 A CN 201210094867A CN 103357058 A CN103357058 A CN 103357058A
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- semen cassiae
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Abstract
The invention provides a contact lenses care solution. The contact lenses care solution is a water solution containing the following components: 0.1-0.5wt% of pyrrolidone sodium carboxylate, 0.05-0.3wt% of vitamin B, 0.05-0.5wt% of a buffering agent, 0.6-0.95wt% of an isoosmotic adjusting agent, 0.05-0.2wt% of a semen cassiae extractive, 0.05-0.2wt% of a chrysanthemum extractive and 0.05-0.2wt% of a mint extractive; and the pH (Potential of Hydrogen) value of the contact lenses care solution is 6-8. The invention further provides a preparation method of the contact lenses care solution. The contact lenses care solution disclosed by the invention adopts a natural antibacterial agent and the pyrrolidone sodium carboxylate so as to have good moisture-keeping effect and good antibacterial effect; and the contact lenses care solution has no toxin and side effects on a human body.
Description
Technical field
The invention belongs to the eye health field, be specifically related to a kind of contact lens care solution and preparation method thereof.
Background technology
Present contact lens care solution on the market mainly integrates the product of the several functions such as sterilization, cleaning, flushing, maintenance.Mostly contain the disinfectant compositions such as hibitane, geramine in this contact lens care solution, eyes are had certain injury.In addition, the moisture-keeping functions of existing contact lens care solution is inadequate, and eyeglass is dry easily, and oxygen transmission rate is low, produces easily the problems such as the dry and astringent discomfort of eyes, inflammation and red blood streak after the user lenses fitted.
Summary of the invention
The invention solves contact lens care solution of the prior art human body is existed murder by poisoning side effect and the relatively poor technical problem of anti-bacteria wet keeping effect.
The invention provides a kind of contact lens care solution, take the gross mass of described contact lens care solution as benchmark, described contact lens care solution is the aqueous solution that contains following each component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
The present invention also provides the preparation method of described contact lens care solution, comprise and being dissolved in the water after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract be mixed in proportion, the adjusting pH value is 6-8, obtains described contact lens care solution.
Contact lens care solution provided by the invention, by adopting pyrrolidone sodium carboxylate as wetting agent, appropriate vitamin B6 is used in simultaneously collocation, can strengthen moistening effect, reduces the eyes inflammation and occurs; In addition, contain the pure natural antibacterial of Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract by employing, nonhazardous has no side effect to human body, also has simultaneously the effect of clearing away heat to improve acuity of vision, antiinflammatory, alleviation eyestrain, nutrition eyes.The preparation method of contact lens care solution provided by the invention, technique is simple, and is easy to implement.
The specific embodiment
The invention provides a kind of contact lens care solution, take the gross mass of described contact lens care solution as benchmark, described contact lens care solution is the aqueous solution that contains following each component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
Contact lens care solution provided by the invention, by adopting pyrrolidone sodium carboxylate as wetting agent, appropriate vitamin B6 is used in simultaneously collocation, can strengthen moistening effect, reduces the eyes inflammation and occurs; In addition, contain the pure natural antibacterial of Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract by employing, nonhazardous has no side effect to human body, also has simultaneously the effect of clearing away heat to improve acuity of vision, antiinflammatory, alleviation eyestrain, nutrition eyes.
Among the present invention, described pyrrolidone sodium carboxylate is used as the wetting agent in the contact lens care solution provided by the invention, the effect that its moisturizing is lubricated; Its performance of keeping humidity obviously is better than polyvinylpyrrolidone of the prior art (PVP), pyrrolidone sodium carboxylate, polyvinyl alcohol (PVA), Polyethylene Glycol (PEG), hyaluronate sodium, poloxamer, glycerol or propylene glycol.
Owing to contain pyrrolidone sodium carboxylate in the human body skin horny layer, be used for keeping the moisture of skin balance, make skin keep moist and elasticity, therefore pyrrolidone sodium carboxylate is called as natural wetting agent, and its moistening effect far is better than common various wetting agents in the prior aries such as glycerol, propylene glycol, sorbitol.In addition, the present inventor finds that the viscosity of pyrrolidone sodium carboxylate also is lower than various wetting agent of the prior art, does not have glycerol sticky thick and heavy, and safe, to skin, eye mucosa nonirritant.
Under the preferable case, take the gross mass of described contact lens care solution as benchmark, the content of pyrrolidone sodium carboxylate is 0.2-0.4wt%.
Vitamin B6 can promote the ability that hyperplasia and material generate, and promotes DNA synthetic, improves immunity, reduces the generation of eyes inflammation, simultaneously can the nutrition ocular nerve, enhance metabolism.Among the present invention, vitamin B6 and pyrrolidone sodium carboxylate are used, and can further strengthen moisture-keeping efficacy.
Contact lens care solution provided by the invention is neutral conditioning liquid.Particularly, the pH value of described contact lens care solution is 6-8.Under the preferable case, the pH value of described contact lens care solution is 6.5-7.5.Among the present invention, the pH value of contact lens care solution adopts various pH adjusting agents commonly used in the prior art to regulate.For example, described pH adjusting agent is selected from hydrochloric acid and/or sodium hydroxide, but is not limited to this.
Among the present invention, the pH value that described buffer agent is used for guarantee system is 6-8, and larger fluctuation does not occur.Described buffer agent can adopt various buffer agents commonly used in the prior art, for example can be selected from boric acid, sodium borate, sodium hydrogen phosphate, sodium dihydrogen phosphate, disodiumedetate, sodium bicarbonate or the Tris (Tris) one or more, but be not limited to this.Among the present invention, described buffer agent preferably adopts Tris (Tris), makes the pH of conditioning liquid be more suitable for ocular environment, thereby avoids stimulation and injury to eyes.Under the preferable case, take the gross mass of described contact lens care solution as benchmark, the content of buffer agent is 0.05-0.3wt%, and the content of isoosmotic adjusting agent is 0.8-0.95wt%.
Contact lens care solution will have the osmotic pressure of similar human tear, so passes through among the present invention to adopt isoosmotic adjusting agent, thereby the osmotic pressure of regulating described contact lens care solution is 250-350osmol/Kg.Described isoosmotic adjusting agent can adopt various isoosmotic adjusting agent commonly used in the prior art, for example can be selected from sodium chloride, potassium chloride, calcium chloride or the magnesium chloride one or more.Under the preferable case, described isoosmotic adjusting agent is sodium chloride, thereby simulation human body tear composition guarantees that conditioning liquid reaches minimum to eye irritation.
Among the present invention, the antibacterial that adopts in the described contact lens care solution is the natural bacteriostatic agent, is specially the mixture of Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract.
Semen Cassiae is the mature seed of leguminous plant Semen Cassiae, and its main component is anthraquinone compounds, also contains the element of naphtho--pyranone, multiple fatty acid, sterol, aminoacid, sugar and needed by human, and the traditional Chinese medical science thinks that Semen Cassiae has the effect of liver heat removing and eyesight improving.Pass through among the present invention to adopt Semen Cassiae extract as antibacterial, it contains anthraquinone analog compound, is main antipathogenic composition, and most of antibacterials are had inhibitory action, can anti-bacteria the biosynthesis of amplifying nucleic acid and respiratory and produce antibacterial activity, improve Abwehrkraft des Koepers.
Among the present invention, the extracting method of described Semen Cassiae extract can adopt the whole bag of tricks of the prior art.For example, take aqueous solution as solvent, under certain pressure, time, temperature, Semen Cassiae is carried out water logging and extract, namely obtain the Semen Cassiae water extract.Perhaps, take ethanol as solvent, Semen Cassiae is carried out soak with ethanol extract, namely obtain the Semen Cassiae ethanol extract.In addition, also can adopt supercritical fluid (CO for example
2) as solvent Semen Cassiae is carried out supercritical extraction, thus the Semen Cassiae supercritical extract obtained.Can also adopt the mode that microwave is combined with ultrasound wave to extract, can improve the content of extraction efficiency and extract.
Adopt different extracting method, the effective ingredient in the extract that obtains can be slightly different.Among the present invention, the concrete extracting method of Semen Cassiae extract is not had particular determination, adopt various extracting method of the prior art all can realize the present invention.
Flos Chrysanthemi is exactly the common medicine for the treatment of ophthalmic since ancient times, and the traditional Chinese medical science thinks that Flos Chrysanthemi can dispelling pathogenic wind for improving eyesight, and it is dry to separate evanescence of heat, dizziness and red eyes.Contain monoterpene, chromocor compound, aminoacid in the Flos Chrysanthemi extract, antibiotic, antivirus action is arranged, gram positive bacteria, multiple pathogenic bacillus are all had inhibitory action, can also suppress capillary permeability, play the effect of inflammation-inhibiting.
Among the present invention, the extracting method of Flos Chrysanthemi extract can adopt the whole bag of tricks commonly used in the prior art.Similarly, for example can adopt water logging to extract, thereby obtain the Flos Chrysanthemi water extract; Perhaps, adopt soak with ethanol to obtain the Flos Chrysanthemi ethanol extract; Also can adopt supercritical fluid (CO for example
2) extract, thereby obtain the Flos Chrysanthemi supercritical extract.
Contain the Herba Menthae quintessence oil in the Folium Menthae extract, peat-reek is arranged, have refrigerant convergence, the refreshment of having one's ideas straightened out can be played the effect of relieving eye strain, antiinflammatory, elimination furuncle.Simultaneously, the distinctive pungent sense of Herba Menthae and cool feeling can stimulate peripheral nerve, cause that reflexive blood capillary shrinks, thereby reach antiinflammatory, pain relieving, antipruritic effect.Similarly, the extracting method of Folium Menthae extract also can adopt the whole bag of tricks commonly used in the prior art among the present invention.For example, can adopt water logging to extract, thereby obtain the Herba Menthae water extract; Perhaps, adopt soak with ethanol to obtain the Herba Menthae ethanol extract; Also can adopt supercritical fluid (CO for example
2) extract, thereby obtain the Herba Menthae supercritical extract.
The present invention also provides the preparation method of described contact lens care solution, comprise and being dissolved in the water after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract be mixed in proportion, the adjusting pH value is 6-8, obtains described contact lens care solution.
The preparation method of contact lens care solution provided by the invention only needs each component is dispersed in the water, and then the pH value of regulation system guarantees that osmotic pressure is 250-350osmol/Kg, can carry out disinfection after the assay was approved, packing.The preparation method of contact lens care solution provided by the invention, technique is simple, and is easy to implement.
In order to make technical problem solved by the invention, technical scheme and beneficial effect clearer, below in conjunction with embodiment, the present invention is further elaborated.The raw material that adopts all is commercially available in embodiment and the Comparative Examples.
Embodiment 1-3
With each component mix homogeneously, formation solution soluble in water then adds hydrochloric acid, sodium hydroxide regulation system pH value is 6-8 in the ratio shown in the table 1, and the detection osmotic pressure is 300osmol/Kg, obtains the contact lens care solution S1-S3 of embodiment 1-3.Be weight percent content in the table 1.
Comparative Examples 1-3
Adopt the step identical with embodiment 1-3 to prepare contact lens care solution sample DS1-DS3, difference is that each component proportion is as shown in table 1.
Table 1
Performance test:
Randomly draw 40 people and try the contact lens that soaks through S1-S3 and DS1-DS3 on, it is as shown in table 2 that the person of trying on experiences.
Adopt the disclosed method of GB19192-2003 that S1-S3 and DS1-DS3 are carried out antibacterial test, test it to the fungistatic effect of staphylococcus aureus, escherichia coli, green pus bacterium and Candida albicans, the qualified OK that is designated as, otherwise be NG.Test result is as shown in table 2.
Table 2
Can find out that from the test result of upper table 1 contact lens care solution provided by the invention has good performance of keeping humidity and bacteriostasis property.
Can find out relatively that from the result of S1-S3 and DS1 the present invention adopts pyrrolidone sodium carboxylate as wetting agent, be used simultaneously vitamin B6, moistening effect obviously strengthens.
Can find out relatively that from the result of S1-S3 and DS2-DS3 the present invention adopts the natural bacteriostatic agent, nonhazardous has no side effect to human body, guaranteeing to have under the prerequisite of good moisturizing and fungistatic effect, can alleviate eyestrain, nutrition eyes, and the person of wearing that has a try feels comfortable.
The above only is preferred embodiment of the present invention, not in order to limiting the present invention, all any modifications of doing within the spirit and principles in the present invention, is equal to and replaces and improvement etc., all should be included within protection scope of the present invention.
Claims (11)
1. a contact lens care solution is characterized in that, take the gross mass of described contact lens care solution as benchmark, described contact lens care solution is the aqueous solution that contains following each component:
Pyrrolidone sodium carboxylate 0.1-0.5wt%;
Vitamin B6 0.05-0.3wt%;
Buffer agent 0.05-0.5wt%;
Isoosmotic adjusting agent 0.6-0.95wt%;
Semen Cassiae extract 0.05-0.2wt%;
Flos Chrysanthemi extract 0.05-0.2wt%;
Folium Menthae extract 0.05-0.2wt%;
The pH value of described contact lens care solution is 6-8.
2. contact lens care solution according to claim 1 is characterized in that, take the gross mass of described contact lens care solution as benchmark, the content of pyrrolidone sodium carboxylate is 0.2-0.4wt%.
3. contact lens care solution according to claim 1 is characterized in that, take the gross mass of described contact lens care solution as benchmark, the content of buffer agent is 0.05-0.3wt%, and the content of isoosmotic adjusting agent is 0.8-0.95wt%.
4. according to claim 1 or 3 described contact lens care solutions, it is characterized in that described buffer agent is selected from one or more in boric acid, sodium borate, sodium hydrogen phosphate, sodium dihydrogen phosphate, disodiumedetate, sodium bicarbonate or the Tris; Described isoosmotic adjusting agent is selected from one or more in sodium chloride, potassium chloride, calcium chloride or the magnesium chloride.
5. contact lens care solution according to claim 4 is characterized in that, described buffer agent is Tris, and described isoosmotic adjusting agent is sodium chloride.
6. contact lens care solution according to claim 1 is characterized in that, the pH value of described contact lens care solution is 6.5-7.5.
7. according to claim 1 or 6 described contact lens care solutions, it is characterized in that the pH value of described contact lens care solution adopts pH adjusting agent to regulate, described pH adjusting agent is selected from hydrochloric acid and/or sodium hydroxide.
8. contact lens care solution according to claim 1 is characterized in that, contains anthraquinone compounds in the described Semen Cassiae extract; Described Semen Cassiae extract is Semen Cassiae water extract, Semen Cassiae ethanol extract or Semen Cassiae supercritical extract.
9. contact lens care solution according to claim 1 is characterized in that, contains monoterpene, chromocor compound, aminoacid in the described Flos Chrysanthemi extract; Described Flos Chrysanthemi extract is Flos Chrysanthemi water extract, Flos Chrysanthemi ethanol extract or Flos Chrysanthemi supercritical extract.
10. contact lens care solution according to claim 1 is characterized in that, contains the Herba Menthae quintessence oil in the described Folium Menthae extract; Described Folium Menthae extract is Herba Menthae water extract, Herba Menthae ethanol extract or Herba Menthae supercritical extract.
11. the preparation method of contact lens care solution claimed in claim 1, it is characterized in that, comprise and being dissolved in the water after pyrrolidone sodium carboxylate, vitamin B6, buffer agent, isoosmotic adjusting agent, Semen Cassiae extract, Flos Chrysanthemi extract and Folium Menthae extract be mixed in proportion, the adjusting pH value is 6-8, obtains described contact lens care solution.
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| CN201210094867.9A CN103357058B (en) | 2012-04-01 | 2012-04-01 | A kind of contact lens care solution and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210094867.9A CN103357058B (en) | 2012-04-01 | 2012-04-01 | A kind of contact lens care solution and preparation method thereof |
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| CN103357058A true CN103357058A (en) | 2013-10-23 |
| CN103357058B CN103357058B (en) | 2015-09-30 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105296214A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Preparation method of contact lens cleaning solution |
| CN105296213A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Contact lens cleaning solution |
| CN106635462A (en) * | 2016-12-14 | 2017-05-10 | 成都锦汇科技有限公司 | Cleaning fluid for glasses |
| CN106692180A (en) * | 2016-12-22 | 2017-05-24 | 珠海博纳百润生物科技有限公司 | Washing and disinfecting liquid used for emergency eye chemical burns, and preparation method thereof |
| CN106955369A (en) * | 2017-05-22 | 2017-07-18 | 陶圣香 | A kind of preparation method of contact lens care solution |
| CN108522547A (en) * | 2018-05-25 | 2018-09-14 | 合肥昂诺新材料有限公司 | A kind of antibacterial conditioning liquid composition and its application |
| CN110819464A (en) * | 2019-10-11 | 2020-02-21 | 陕西仁康药业有限公司 | Hard corneal contact lens care solution and preparation method thereof |
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| CN101574537A (en) * | 2009-06-01 | 2009-11-11 | 海昌隐形眼镜有限公司 | Composition for contact lens solution containing peppermint and preparation method thereof |
| CN101790694A (en) * | 2007-08-31 | 2010-07-28 | 诺瓦提斯公司 | Contact lens products |
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2012
- 2012-04-01 CN CN201210094867.9A patent/CN103357058B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101790694A (en) * | 2007-08-31 | 2010-07-28 | 诺瓦提斯公司 | Contact lens products |
| CN101574537A (en) * | 2009-06-01 | 2009-11-11 | 海昌隐形眼镜有限公司 | Composition for contact lens solution containing peppermint and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105296214A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Preparation method of contact lens cleaning solution |
| CN105296213A (en) * | 2015-11-30 | 2016-02-03 | 谢松芬 | Contact lens cleaning solution |
| CN106635462A (en) * | 2016-12-14 | 2017-05-10 | 成都锦汇科技有限公司 | Cleaning fluid for glasses |
| CN106692180A (en) * | 2016-12-22 | 2017-05-24 | 珠海博纳百润生物科技有限公司 | Washing and disinfecting liquid used for emergency eye chemical burns, and preparation method thereof |
| CN106955369A (en) * | 2017-05-22 | 2017-07-18 | 陶圣香 | A kind of preparation method of contact lens care solution |
| CN108522547A (en) * | 2018-05-25 | 2018-09-14 | 合肥昂诺新材料有限公司 | A kind of antibacterial conditioning liquid composition and its application |
| CN110819464A (en) * | 2019-10-11 | 2020-02-21 | 陕西仁康药业有限公司 | Hard corneal contact lens care solution and preparation method thereof |
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| CN103357058B (en) | 2015-09-30 |
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