CN101837068B - Preparation process of zanthoxylum oil spray and application thereof - Google Patents
Preparation process of zanthoxylum oil spray and application thereof Download PDFInfo
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- CN101837068B CN101837068B CN2010101845242A CN201010184524A CN101837068B CN 101837068 B CN101837068 B CN 101837068B CN 2010101845242 A CN2010101845242 A CN 2010101845242A CN 201010184524 A CN201010184524 A CN 201010184524A CN 101837068 B CN101837068 B CN 101837068B
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Abstract
The invention relates to a preparation process of zanthoxylum oil spray and application thereof; the zanthoxylum oil is taken as main raw material to prepare external preparation for treating burns and scalds, belonging to the field of technology of pharmaceutics and clinical application. The preparation process is characterized in that: the preparation contains 50-95 percent of zanthoxylum oil, 1-5 percent of Vitamin E and 2-40 percent of colza oil. The preparation method comprises the following specific steps: the zanthoxylum oil is added in the Vitamin E, the mixture is stirred uniformly and filtered, and then the colza oil is added to have the designed scalar, the mixture is stirred uniformly, canned and closed. The zanthoxylum oil spray has the advantages of convenient usage, good film-forming performance, being easy to long-term preservation and low price, and the zanthoxylum oil spray has good curative effect on treating burns and scalds.
Description
Affiliated technical field
The present invention relates to a kind of zanthoxylum oil spray and preparation method thereof, the treatment that is used to burn.The invention belongs to pharmaceutical preparation and clinical practice field.
Background technology
Burn is that many factors such as physics, chemistry, lonizing radiation act on body and a kind of extremely complicated traumatic disease of causing, also is a kind of common war wound, accounts for 10%～30% of war wound.Because the treatment of burn is flat to the modern times, the influence of accident in wartime is very big; After the World War II; National governments and medical circle to widely pay attention to; Burn medical science has had tremendous development, and treatment level significantly improves, from burn early stage liquid resuscitation, infection control, nutritional support, burn wound cover in early days and rehabilitation all be improved significantly.The progress of these Therapeutic Method has obviously reduced the burn mortality rate, has prolonged serious burn patient's time-to-live.But still there are wound pain, necrosis progrediens, easy infection, scar healing difficulty four problems in the burn treating.
The burn CC is general to be divided for three phases, and promptly shock (body fluid oozes out) phase, acute infection period, wound surface function are repaired the phase; And medicine mainly comprises systemic administration, topical agent and wound-surface cover etc.; Present technique relates generally to the wound surface formulation problems.What use was the widest in the wound surface cleaning antibacterials is silver sulfadiazine, and it has remarkable result to the control traumatic infection, but pair cell also has certain detrimental effect, particularly uses the silver sulfadiazine paste or the suspensoid of high concentration, the fraud that has the wound surface of making infringement to increase the weight of.For promoting the wound healing medicine, clinical multimeter skin cell growth factor (EGF) etc. promote burn reparation.Because it is more that the fire victim is oozed out in early days, the EGF concentration that is sprayed at the affected part is diluted, and slough does not come off and can't penetrate simultaneously, make it in the early stage effect of burn and not obvious, and the intermediary and later stages curative effect is better.But above-mentioned preparation costs an arm and a leg, less stable.Therefore, wound is effectively handled in exploitation rapidly, alleviating pain, and short incrustation and wound healing, inexpensive burn treating medicine is still present research direction.
Semen zanthoxyli oil is the lubricant component that Semen zanthoxyli (Zanthoxylum bungeanum Mazim) squeezing obtains, and is rich in fatty acid, volatile ingredient and various trace elements.Wherein, unsaturated fatty acid content reaches 70%, is mainly alpha-linolenic acid and linoleic acid; Volatile ingredient is main with menthone, terpineol, sabinene, myrcene etc.; Trace element is mainly manganese, zinc, calcium, magnesium etc.Modern pharmacology research confirms that fatty acid has good penetration property, and the main barrier structure of participating in forming skin is the important component of cell wall lipid layer; Simultaneously, also be the precursor that arachidonic acid belongs to, the anti-inflammatory response of burn wound is to lean on the metabolism of fatty acid to accomplish.Volatile ingredient has antibacterial, bacteriostatic effect.Trace element is the key component of plurality of enzymes and protein system, can quicken skin metabolism, and institute is essential for the wound surface Regeneration and Repair.In addition, the Semen zanthoxyli oil moisture-free can make skin wet, not flood, and safeguards effects such as burn wound's moisture thus.Our pharmacological evaluation shows that Semen zanthoxyli oil spreads upon dark II degree burn and scald skin surface, can form layer protecting film, and minimizing is oozed out, and shortens the healing time and the decrustation time of scald wound.Treat the reality that burn and scald has fine purposes in view of Semen zanthoxyli oil, we are effective site with the Semen zanthoxyli oil, adopt the medication of spray preparation process exploitation treatment empyrosis wound surface significant.
Summary of the invention
The object of the present invention is to provide a kind of Semen zanthoxyli oil spray agent of treating burn and scald; This product has rapid film forming, reduce ooze out, protect wound surface, promote wound healing, characteristics such as antibiotic, low toxicity, inexpensive, long shelf-life, be applicable to different parts, difference hinder face gently, in, the severe burn and scald.
Technical scheme: the pharmaceutical formulation of zanthoxylum oil spray (by weight percentage) is a Semen zanthoxyli oil 50%～95%, vitamin E 1%～5%, Oleum Brassicae campestris 2%～40%.
Method for preparing: get Semen zanthoxyli oil adding vitamin E and stir, filter, add Oleum Brassicae campestris, stir to designing scalar, fill, airtight.
The zanthoxylum oil spray of invention is applicable to the treatment burn and scald.
Specific embodiment
Enumerate exemplary embodiments below, the present invention is further specified, but be not construed as limiting the invention in any form.
Embodiment 1: the preparation of zanthoxylum oil spray
(1) prescription
Semen zanthoxyli oil 90ml
Vitamin E 5ml
Oleum Brassicae campestris adds to 100ml
(2) method for preparing
Get Semen zanthoxyli oil 90ml adding vitamin E 5ml and stir, filter, add Oleum Brassicae campestris, stir to 100ml, fill, airtight.
Embodiment 2: zanthoxylum oil spray is to the therapeutical effect of rat deep
Laboratory animal: 40 of SD rats, male and female are regardless of, and body weight 250 ± 20g is provided by The Fourth Military Medical University's Experimental Animal Center.
Experiment is divided into groups: rat is divided into 4 groups at random: model group, solvent control group (Oleum Brassicae campestris), Semen zanthoxyli oil group, positive controls (JINGWANHONG), 10 every group.
The model preparation: adult rat is selected in experiment for use, prepares dark II degree scald wound.Fasting 12h before the zoopery; After the anesthesia of 3% pentobarbital sodium, laboratory table upwards is fixed at the back, and hair is shaved in back and both sides thereof, and guarantees enough gross areas of shaving; With the depilation of 80g/L sodium sulfide, the reuse warm water washes the sodium sulfide on the residual skin.Local iodophor solution sterilization.Behind the water boiling 5min, 15s is carried out at the scald position of rat scald.Replenish normal saline after the scald immediately, and press experimental design grouping and treatment, change dressings every day 1 time, until wound healing.
The wound surface morphological observation: postoperative is observed rat wound healing situation every day, comes off with wound surface sealing, dry tack free, eschar and recovers normally to be regarded as healing, observes and respectively organizes healing time and carry out statistical procedures.
Wound healing rate: hinder and began to detect the wound healing area the back same day.Earlier wound surface is traced on onionskin,, the uniform hard paper of quality is cut into onesize, weigh quality then in the balance, with hard paper quality secondary indication wound surface area size again as template.By formula [wound healing rate (%)=(original wound surface area one do not heal wound surface area)/original wound surface area] calculates 6d, 12d, 18d, 24d wound healing rate.
Statistical procedures: experimental data is with mean ± standard deviation
expression, and sample average relatively adopts variance analysis to handle between many groups.
The result: after the preparation of burn model, each treated animal wound surface is red and white or pale asphyxia changes, and edema occurs; After 3 days; Each treatment group edema alleviates, and incrustation early, and is visible from wound healing time result (table 1); Semen zanthoxyli oil group healing time is 19.40 ± 2.68d, obviously early than model group and group of solvents (P＜0.01); The Semen zanthoxyli oil group is treated back the 6th, 12,18d wound healing rate and model group, more all there were significant differences for group of solvents (P＜0.05) (table 2), and the 6th day healing rate can reach 65.47 ± 15.12%, 24 days wounds and heal fully, and cicatrization is few, and more the back is effective.Above result shows that Semen zanthoxyli oil has tangible burn treating effect.
The influence of table 1 pair wound tissue healing of burned rat models time (n=10,
)
Annotate: compare with model group
*P＜0.01.
Influence (the % of table 2 pair burned rats wound surface different time healing rate; N=10,
)
Annotate: compare with model group
*P＜0.01;
#P＜0.05
Claims (3)
1. zanthoxylum oil spray of treating burn and scald, it forms with content following:
Semen zanthoxyli oil 90ml
Vitamin E 5ml
Oleum Brassicae campestris adds to 100ml.
2. the method for preparing of zanthoxylum oil spray according to claim 1 is characterized in that: gets Semen zanthoxyli oil 90ml, adds vitamin E 5ml, stir, filter, add Oleum Brassicae campestris, stir to 100ml, and fill, airtight.
3. the application of zanthoxylum oil spray according to claim 1 in preparation treatment burn and scald medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101845242A CN101837068B (en) | 2010-05-27 | 2010-05-27 | Preparation process of zanthoxylum oil spray and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101845242A CN101837068B (en) | 2010-05-27 | 2010-05-27 | Preparation process of zanthoxylum oil spray and application thereof |
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| Publication Number | Publication Date |
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| CN101837068A CN101837068A (en) | 2010-09-22 |
| CN101837068B true CN101837068B (en) | 2012-02-22 |
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| CN2010101845242A Expired - Fee Related CN101837068B (en) | 2010-05-27 | 2010-05-27 | Preparation process of zanthoxylum oil spray and application thereof |
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| CN102204984A (en) * | 2011-05-12 | 2011-10-05 | 中国人民解放军第四军医大学 | Zanthoxylum bungeanum seed kernel oil ointment and preparation process thereof |
| CN102973487A (en) * | 2011-09-03 | 2013-03-20 | 颜平安 | Air-pushed medicinal oil drop and preparation method for products thereof |
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| CN1239186C (en) * | 2003-05-06 | 2006-02-01 | 徐虎林 | Soft hypolipidemic Jiaosuan capsule and its production process |
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Granted publication date: 20120222 Termination date: 20140527 |