CN104161808B - It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug - Google Patents
It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug Download PDFInfo
- Publication number
- CN104161808B CN104161808B CN201310183997.4A CN201310183997A CN104161808B CN 104161808 B CN104161808 B CN 104161808B CN 201310183997 A CN201310183997 A CN 201310183997A CN 104161808 B CN104161808 B CN 104161808B
- Authority
- CN
- China
- Prior art keywords
- preparation
- burn
- scald
- drug
- coriaria sinica
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug, belongs to medication chemistry technology, is related to treating burn, the preparation method of the pharmaceutical composition of scald and its drug by a kind of of active drug ingredient of natural drug.The effect of present invention is a kind of to treat burn, the preparation method of the pharmaceutical composition of scald and its drug, which there is detumescence and promoting granulation, hygroscopic sore, myogenic to hold back mouth, antibacterial anti-inflammatory, and the protection surface of a wound prevents from infecting, wound is promoted to heal rapidly.The present invention treats burn, the pharmaceutical composition of scald is made of Hydrangea xanthoncura Diels, Coriaria sinica, Platycarya strobilacea；Preparation method is：Using Hydrangea xanthoncura Diels, Coriaria sinica and three taste medicinal material of Platycarya strobilacea as raw material, Hydrangea xanthoncura Diels, Coriaria sinica, three taste medicinal material of Platycarya strobilacea are mixed, extracting in water, filter extracting solution, filtrate concentration is medicinal extract, is cooled to room temperature up to treatment burn, scald medicament.Drug application method of the present invention is simple, is not processed to patient wound surface, adds medicine to immediately, and analgesic, is mitigated or eliminated the pain of injury in the short time.
Description
Technical field
The invention belongs to medication chemistry technology, be related to using natural drug as active drug ingredient it is a kind of treat burn, scald
The pharmaceutical composition of wound and its preparation method of drug.
Background technology
Burn and scald are that high temperature, radiation, strong light etc. are to skin as caused by external cause, the damage of muscle, once to skin
It causing to damage, morbidity is rapid, cannot such as treat in time, the bubble that less serious case erythema occurs, differs in size, rotting occurs in severe one,
The symptoms such as suppuration.
Treatment burn or scald medicament and method are broadly divided into following a few classes at present：One kind is the medicine based on doctor trained in Western medicine
Object and remedy measures；One kind is the treatment route based on Chinese medicine；Have again is exactly that Chinese and Western shares.Western medical treatment is burnt, and is that will burn
Hinder face after cleaning and sterilizing, then carry out the processing of necrotic muscle tissue to wound, then wrap up, does not advocate that the surface of a wound is added medicine to, it is main
Will be based on innerlich anwenden object, the surface of a wound is almost directly handled without any drug.This method seems science, actually can not be quickly
Slow down patient pain, and spends extremely expensive.One kind is the traditional Chinese medicine treatment route in China, i.e., on the basis of theory of traditional Chinese medical science
On, there are the opinion and remedy measures, including some civil prescriptions etc. of oneself for treatment burn.The prescription of the present invention is by civil
Proved recipe carries out what full-scale development research was got, and through patent retrieval, there is presently no the external applications with Same Chinese Herbal Medicine material compatibility of the present invention
Burn and scald medicine.
Invention content
Burn, the pharmaceutical composition of scald are treated the technical problem to be solved in the present invention is to provide a kind of, which has
The effect of detumescence and promoting granulation, hygroscopic sore, myogenic hold back mouth, antibacterial anti-inflammatory, and the protection surface of a wound prevents from infecting, wound is promoted to heal rapidly.
The invention solves another technical problem be to provide a kind of preparation method of drug that treating burn, scald,
There is drug prepared by this method detumescence and promoting granulation, hygroscopic sore, myogenic to hold back mouth, antibacterial anti-inflammatory, and the protection surface of a wound prevents from infecting, promote
The effect of wound heals rapidly.
The present invention solve technical problem technical solution be：
The present invention treats burn, the pharmaceutical composition of scald is made of Hydrangea xanthoncura Diels, Coriaria sinica, Platycarya strobilacea, and main points are,
Composition weight part is：Hydrangea xanthoncura Diels 1-5, Coriaria sinica 0.5-4, Platycarya strobilacea 1-6.
The present invention treats burn, the preparation method of scald medicament is：It is with Hydrangea xanthoncura Diels, Coriaria sinica and three taste medicinal material of Platycarya strobilacea
Raw material mixes Hydrangea xanthoncura Diels, Coriaria sinica, three taste medicinal material of Platycarya strobilacea, extracting in water, filters extracting solution, filtrate concentration is medicinal extract, cold
But burn, scald medicament are treated to obtain the final product to room temperature.
The method of extracting in water described in preparation method of the present invention is plus dosing material raw material weight 5 --- 20 times of amount water extract
1 --- 5 times.
Filtrate concentration described in preparation method of the present invention is that concentrate the filtrate to relative density be 1.0 to medicinal extract --- 1.4
Medicinal extract.
The present invention treats burn, the dosage form of scald medicament is gelling agent, paste, spray or aerosol.
The present invention treats burn, the dosage form of scald medicament, and the preparation method of described gelling agent is to take carbomer appropriate, is made
It is fully swollen, and is added in the medicinal extract of Hydrangea xanthoncura Diels, Coriaria sinica, three taste medicinal material of Platycarya strobilacea, stirring while adding, is stirred until homogeneous, so
PH value=5 are adjusted in right amount with triethanolamine afterwards --- 7；Distilled water is added to modulate to obtain gelling agent.
The beneficial effects of the invention are as follows：
Pharmaceutical composition of the present invention is the proved recipe from clinic, which there is detumescence and promoting granulation, hygroscopic sore, myogenic to hold back
The effect of mouth, antibacterial anti-inflammatory, the protection surface of a wound prevents from infecting, wound is promoted to heal rapidly.Human body is fully stimulated by external used medicine
The power of regeneration of cell promotes musculature fast-growth again, to reach the therapeutic effect fully recovered in short term.Its application method
Simply, patient wound surface is not processed, is added medicine to immediately, analgesic, is mitigated or eliminated the pain of injury in the short time.External used medicine effect
More directly, dressing is simple, and pain is few, is conducive to the variation of the observation surface of a wound, and the medicine film that drug is formed in the surface of a wound is effectively kept water
Point, make the surface of a wound keep wetting, more after do not stay scar, no hormone to have no toxic side effect.Burn the burn and scald of skin for heat toxin, ultraviolet light spoke
It shoots wounded, electric injury etc..
Medicine material selected by the present invention has the function of as follows：
Coriaria sinica (Coriaria sinica Maxim) has clearing heat and detoxicating, swelling and pain relieving, myogenic and other effects, civil to be used for
Treat ulcer, pyogenic infections, mange, impetigo, acute and chronic conjunctivitis, scald, fracture, Fall injuries, rheumatic numbness etc..
Platycarya strobilacea（Platycarya strobilacea ）With clearing heat and detoxicating, promoting blood circulation and removing blood stasis, detumescence and apocenosis, it is sensible only
The effect of pain.
Hydrangea xanthoncura Diels（Hydrangea xanthoneura Diels）With clearing heat and detoxicating, promoting blood circulation and other effects, cure mainly
Nameless sores or boils, malignant sore etc..
According to its major function, We conducted preclinical pharmacodynamic studies related with major function.
1. this product is to the Healing of deep three degree of After Scalding In Rat wound faces：4g/kg dosage groups, 2g/kg dosage groups, 1g/kg
Dosage group three degree of scalds wound face effect of being significantly improved deep to rat（P<0.01 or P<0.05）.To under the weight of After Scalding In Rat
The effect of being significantly improved is dropped：4g/kg dosage groups, 2g/kg dosage groups are significantly improved work to the weight loss of After Scalding In Rat
With（P<0.01 or P<0.05）.Influence to histopathology：4g/kg dosage groups, 2g/kg dosage groups, 1g/kg dosage groups can be apparent
Reduce scald position epidermal structure, collagenous fibres, the histological scores of inflammatory cell（P<0.01 or P<0.05）.
2. this product is to the Healing of the deep second degree burn rat surface of a wound：4g/kg dosage groups, 2g/kg dosage groups, 1/kg dosage
Group is to the effect of being significantly improved of rat deep second degree burn wound face（P<0.01 or P<0.05）.This product puies forward the weight of Burns in Rats
Height effect：4g/kg dosage groups, 2g/kg dosage groups can significantly improve rat body weight（P<0.01 or P<0.05）.This product is to tissue disease
The influence of reason：4g/kg dosage groups can obviously reduce the pathology that burned part epidermal structure, collagenous fibres, granulocyte infiltrate and comment
Point.
3. this product is to the Healing of the mouse deep second degree burn surface of a wound：5g/kg dosage groups, 2.5g/kg dosage groups,
1.25g/kg dosage groups are to the effect of being significantly improved of mouse deep second degree burn wound face（P<0.01 or P<0.05）.This product is to burn
The raising of rat body weight acts on：5g/kg dosage groups can obviously increase mouse weight（P<0.01）The influence of this product histopathology：
5g/kg dosage groups, 2.5g/kg dosage groups, 1.25g/kg dosage groups can obviously reduce burned part epidermal structure, collagenous fibres,
The histological scores of granulocyte infiltration（P<0.01 or P<0.05）.
4. this product paraxylene causes the inhibiting effect of mice ear：Paraxylene causes mice ear to inhibit to make without apparent
With.
5. influence of this product to mouse peritoneal capillary permeability:5g, 2.5g, 1.25g/kg dosage group can obviously subtract
The seepage discharge of few mouse peritoneal Yi Wensilan, inhibits capillary permeability.（P ＜ 0.01 or P ＜ 0.05）.
5. this product is to the inhibiting effect of rat toes swelling：4g/kg dosage groups, 2g/kg dosage groups, 1/kg dosage groups can be bright
It is aobvious to reduce rat toes swelling rate（P<0.01 or P<0.05）.
7. this product causes glacial acetic acid the influence of mouse writhing reaction:Mouse writhing incubation period and 20min caused by Dichlorodiphenyl Acetate
Interior writhing number has a significant effect.
8. this product causes mouse to lick sufficient influence hot plate：Have to mouse pain threshold caused by hot plate and analgesia percentage bright
Development is rung.Clinical observation confirmation has significant analgesic effect.
9. the inhibition and killing effect of 4 kinds of skin common bacterias of this product pair：In vitro test prompts, and this product is to wherein to golden yellow
Color staphylococcus, staphylococcus epidermis, pseudomonas aeruginosa and Escherichia coli MIC be 1:16、1:8、1:4、1:32.
10. influence of this product to guinea pig skin sensitivity test：To guinea pig skin without sensitization.
11. influence of this product to family's rabbit skin single irritant test：This product single medication contacts skin 6 hours, to rabbit
Intact skin damaged skin is nonirritant.Influence of this product to the multiple irritant test of family's rabbit skin：This product continuous use contacts
Skin 7 days is observed 7 days, and to rabbit intact skin, damaged skin is nonirritant.
Conclusion：This product has certain repair to the surface of a wound of deep 3 degree of After Scalding In Rats；This product is to deep 2 degree of Burns in Rats
The surface of a wound has certain repair；This product has the surface of a wound of mouse deep second degree burn certain promotion Healing；This product pair two
Toluene causes mice ear without obvious inhibiting effect；This product has mouse peritoneal capillary permeability certain inhibiting effect；
This product can significantly reduce toes swelling rate；This product causes mouse writhing to have apparent analgesic activity in glacial acetic acid；This product hot plate causes
Mouse, which licks foot, apparent analgesic activity.This product has significant In Vitro Bacteriostasis；This product is reacted without apparent allergic stimulated.
Compared with prior art, the present invention technology is easy to implement.
Specific implementation mode
Embodiment 1
Hydrangea xanthoncura Diels 3kg, tri- taste pulverizing medicinal materials of Coriaria sinica 1kg, Platycarya strobilacea 2kg, mixing is taken to add 5 times of amount water to extract 5 times, close
And filtrate is concentrated into the medicinal extract that relative density is 1.4, is cooled to room temperature up to treatment burn, scald medicament.The pharmaceutical composition
Dosage form be gelling agent, paste, spray, aerosol.
Embodiment 2
Hydrangea xanthoncura Diels 1kg, tri- taste pulverizing medicinal materials of Coriaria sinica 3kg, Platycarya strobilacea 4kg, mixing is taken to add 15 times of amount water to extract 1 time, close
And filtrate is concentrated into the medicinal extract that relative density is 1.3, is cooled to room temperature spare；It takes carbomer appropriate, it is made fully to be swollen；It is added
It is stirring while adding in above-mentioned liquid extract, it is appropriate with triethanolamine after stirring evenly, adjust PH5；Add distilled water modulate, stir evenly, divide
Dress, sterilizing, thus obtaining the product dosage form are the treatment burn of gelling agent, scald medicament.
Embodiment 3
Take Hydrangea xanthoncura Diels 2kg, tri- taste pulverizing medicinal materials of Coriaria sinica 0.5kg, Platycarya strobilacea 5kg, mixing that 6 times of amount water is added to extract 4 times,
Merging filtrate is concentrated into the medicinal extract that relative density is 1.0, is cooled to room temperature up to treatment burn, scald medicament.The pharmaceutical composition
The dosage form of object is gelling agent, paste, spray, aerosol.
Embodiment 4
Take Hydrangea xanthoncura Diels 2.5kg, tri- taste pulverizing medicinal materials of Coriaria sinica 4kg, Platycarya strobilacea 6kg, mixing that 18 times of amount water is added to extract 3 times,
Merging filtrate is concentrated into the medicinal extract that relative density is 1.0, is cooled to room temperature up to treatment burn, scald medicament.The pharmaceutical composition
The dosage form of object is gelling agent, paste, spray, aerosol.
Embodiment 5
Take Hydrangea xanthoncura Diels 3.5kg, tri- taste pulverizing medicinal materials of Coriaria sinica 2kg, Platycarya strobilacea 5kg, mixing that 16 times of amount water is added to extract 4 times,
Merging filtrate is concentrated into the medicinal extract that relative density is 1.1, is cooled to room temperature up to treatment burn, scald medicament.The pharmaceutical composition
The dosage form of object is gelling agent, paste, spray, aerosol.
Burn, the pharmaceutical composition of scald of the present invention promotes wound healing trend apparent after burn, scald, to deep three
Degree, deep second degree burn, scald have apparent inhibiting effect.It can obviously reduce burn, scald position epidermal structure, collagenous fibres,
Inflammatory cell has the surface of a wound certain repair, and the medicine analgesic effect is apparent.Usage：External application is smeared, and twice daily, is uniformly applied
It smears in affected part.
Claims (6)
1. a kind for the treatment of burn, the pharmaceutical composition of scald, the composition is made of Hydrangea xanthoncura Diels, Coriaria sinica, Platycarya strobilacea, special
Sign is：Composition weight part is：Hydrangea xanthoncura Diels 1-5, Coriaria sinica 0.5-4, Platycarya strobilacea 1-6.
2. a kind for the treatment of burn, the preparation method of scald medicament, it is characterized in that：Using parts by weight as Hydrangea xanthoncura Diels 1-5, Coriaria sinica
The three taste medicinal materials of 0.5-4, Platycarya strobilacea 1-6 are raw material, and Hydrangea xanthoncura Diels, Coriaria sinica, three taste medicinal material of Platycarya strobilacea are mixed, water is added to carry
It takes, filters extracting solution, filtrate concentration is medicinal extract, is cooled to room temperature up to treatment burn, scald medicament.
3. preparation method according to claim 2, it is characterized in that：The method of described extracting in water is plus 5-20 times are measured
Water extracts 1-5 times.
4. preparation method according to claim 2, it is characterized in that：It is to concentrate the filtrate to phase that described filtrate concentration, which is medicinal extract,
The medicinal extract for being 1.0-1.4 to density.
5. preparation method according to claim 2, it is characterized in that：The pharmaceutical dosage form of preparation is gelling agent, paste, spray
Or aerosol.
6. preparation method according to claim 5, it is characterized in that：The preparation method of described gelling agent is to take carbomer suitable
Amount, makes it fully be swollen, and is added in the medicinal extract of Hydrangea xanthoncura Diels, Coriaria sinica, three taste medicinal material of Platycarya strobilacea, stirring while adding, stirs to equal
It is even, then pH value=5-7 are adjusted in right amount with triethanolamine；Distilled water is added to modulate to obtain gelling agent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310183997.4A CN104161808B (en) | 2013-05-17 | 2013-05-17 | It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310183997.4A CN104161808B (en) | 2013-05-17 | 2013-05-17 | It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104161808A CN104161808A (en) | 2014-11-26 |
| CN104161808B true CN104161808B (en) | 2018-07-13 |
Family
ID=51905934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310183997.4A Active CN104161808B (en) | 2013-05-17 | 2013-05-17 | It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104161808B (en) |
-
2013
- 2013-05-17 CN CN201310183997.4A patent/CN104161808B/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CN104161808A (en) | 2014-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103638404B (en) | A kind of detoxifying and relieving itching sterilization ointment and preparation method thereof | |
| CN105250696A (en) | Traditional Chinese medicine gel capable of promoting skin wound to heal and preparation method of traditional Chinese medicine gel | |
| CN102755573A (en) | External use traditional Chinese medicine for treating onychomycosis | |
| CN103007000A (en) | New medicine for treating burns and wounds and preparation method thereof | |
| CN102579709B (en) | Scar preventing and removing burn oil and preparation method thereof | |
| CN101711807B (en) | Antiphlogistic and antibiotic ointment | |
| CN104306402B (en) | A kind of Chinese medicine composition for treating burn and scald infection and preparation method thereof | |
| CN103768388A (en) | Traditional Chinese medicine formula for treating scalds, burns and trauma by being singly applied externally | |
| CN104161808B (en) | It is a kind of to treat burn, the preparation method of the composition of scald medicament and its drug | |
| CN104815068A (en) | Cefalexin ointment and preparation method thereof | |
| CN100531781C (en) | Chinese medicine composition for removing wart nevus | |
| CN108721442B (en) | Traditional Chinese medicine composition and preparation for treating burns, scalds and diaper dermatitis and preparation method thereof | |
| KR20120137134A (en) | Pharmaceutical composition for burn treatment using gombo-baechu | |
| CN102205023B (en) | Powder for diminishing inflammation and healing trauma | |
| CN104435566A (en) | External medicine for treating animal wound and preparation method of external medicine | |
| CN103585330B (en) | A kind of Chinese medicine composition for cutaneous fungal infection and preparation method thereof | |
| CN104491462B (en) | A kind of pharmaceutical composition for the treatment of scald | |
| CN104398796B (en) | One kind oozes out dermatoses Wet-dressing agent and preparation method thereof | |
| CN110876770B (en) | Traditional Chinese medicine spray for treating plaster allergy and preparation method | |
| CN102133324B (en) | Ointment for treating skin burns and scalds | |
| CN107149641A (en) | A kind of composition for being used to treat burn and scald | |
| CN108324721B (en) | Pharmaceutical composition and preparation method and application thereof | |
| CN104337862B (en) | A Chinese medicinal composition for treating burn and scald, and its preparation method | |
| CN105560837A (en) | Drug for treating skin injuries and preparation method thereof | |
| CN112336805A (en) | Scald oil and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 725000 Ankang East Road, Ankang hi tech Industrial Development Zone, Ankang City, Shaanxi Province, No. 2 Patentee after: Ankang Innovation Institute of Chinese Pharmaceutical Research Co.,Ltd. Address before: 725000 Ankang East Road, Ankang hi tech Industrial Development Zone, Ankang City, Shaanxi Province, No. 2 Patentee before: ANKANG PHARMACEUTICAL INSTITUTE OF PEKING University |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: The invention relates to a medicine composition for treating burns and scalds and a preparation method thereof Effective date of registration: 20201215 Granted publication date: 20180713 Pledgee: Ankang city credit financing Company limited by guarantee Pledgor: Ankang Innovation Institute of Chinese Pharmaceutical Research Co.,Ltd. Registration number: Y2020980009364 |