CN106310350A - Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof - Google Patents
Hydrogel woundplast containing traditional Chinese medicine extracts and preparation method thereof Download PDFInfo
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- CN106310350A CN106310350A CN201610948944.0A CN201610948944A CN106310350A CN 106310350 A CN106310350 A CN 106310350A CN 201610948944 A CN201610948944 A CN 201610948944A CN 106310350 A CN106310350 A CN 106310350A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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Abstract
The invention relates to a hydrogel woundplast containing traditional Chinese medicine extracts and a preparation method thereof. The hydrogel woundplast comprises a back lining layer, a medicated hydrogel layer and a stripping layer. The preparation method comprises the following steps: uniformly mixing the following components in percentage by weight: 0.5-4.0% of chitosan, 1.0-3.0% of polyvinyl alcohol, 0.2-1.0% of gelatin, 1.0-3.0% of glycerol, 0.5-2.5% of menthol, 0.2-1.0% of coptis extract, 1.0-2.5% of honeysuckle flower extract, 15-25% of anhydrous ethanol and 50-80% of distilled water; performing cyclic refrigerating-melting treatment to obtain the medicated hydrogel layer; bonding the back lining layer on one side of the hydrogel layer; and bonding the stripping layer on the other side of the hydrogel layer. The hydrogel woundplast containing traditional Chinese medicine extracts is simple in structure and convenient to use, and can absorb wound surface exudates and keep wound wetness; and meanwhile, the hydrogel woundplast has the effects of resisting bacteria, diminishing inflammation and stopping bleeding, and can effectively accelerate wound healing.
Description
Technical field
The present invention relates to a kind of adhesive bandage and preparation method thereof, being specifically related to a kind of hydrogel containing Chinese medicine extract wound can
Patch and preparation method thereof, belongs to field of medical article technology.
Background technology
Adhesive bandage be a kind of play protection wound, prevent wound contamination, promote wound healing medical supplies.Tradition wound can
Patch has that volume is little, use the advantages such as simple, easy to carry.But the adhesive plaster poor air permeability that it is used, body local normally divides
The perspiration secreted can not pass through adhesive plaster, therefore easily causes a crease in the skin.Meanwhile, the wound protective pad layer of tradition adhesive bandage cannot keep wound
Mouth is moistening, and easily sticks together with wound, thus causes secondary damage.
Hydrogel is a kind of swelling body of the net high-polymer containing large quantity of moisture, at wound dressing, artificial skin, osseous tissue
The aspects such as support are widely used.Prepare hydrogel and typically use macromolecular material, including natural macromolecular material and synthesis high score
Sub-material.The good biocompatibility of natural macromolecular material, but mechanical strength is poor；Synthesis macromolecular material is through suitable thing
Reason, chemical modification, can obtain performance widely, meet different needs, but its biocompatibility is poor.By natural polymer material
Expect that being combined preparation hydridization macromolecule hydrogel with synthesis macromolecular material can retain the mechanical strength of synthesis macromolecular material, also can
Keep the biocompatibility of natural macromolecular material.Chitosan is a kind of natural macromolecular material, and its gel has good resisting
Bacterium property, biocompatibility, biodegradability.Polyvinyl alcohol is a kind of water-soluble high-molecular material, and its gel has good
Biocompatibility, biodegradability and mechanical performance.Gelatin has the double grading of protein and material concurrently, and having biology can drop
Solution property and biocompatibility.By polyvinyl alcohol, chitosan, gelatin triplicity, the hydrogel that availability is excellent.
Hydrogel is used for Wound healing and bone regeneration, has the advantages such as good biocompatibility, good water absorption, good permeability, the most permissible
Keep wound surface moistening and wound surface fits tightly but adhesion, thus promote wound healing, shorten wound healing time, but it resists
Bacterium performance has to be strengthened.In hydrogel, add antimicrobial component can give hydrogel antibacterial functions, but life-time service chemical classes resists
Health can be worked the mischief by mushroom agent.Chinese medicine has good anti-bacterial effect, safety is high, be not likely to produce the advantages such as drug resistance, Chinese medicine
One of antibacterial focus being increasingly becoming clinical research.
Rhizoma Coptidis derives from the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis teeta, have clearing away heat-fire,
Dampness, effect of removing toxic substances.Modern pharmacology research shows, Rhizoma Coptidis extract has the merits such as anti-inflammation, antiviral, antitumor
Effect.
Flos Lonicerae is the alabastrum being dried caprifoliaceae plant Radix Ophiopogonis or the flower just opened, and has heat-clearing and toxic substances removing, the merit of cool breeze heat radiation
Effect.Modern pharmacology experimental studies have found that, Flos Lonicerae has stronger inhibitory action to the toxin that various pathogens is secreted, to common carefully
Bacterium infects preferable clinical efficacy.
The present invention, with polyvinyl alcohol, chitosan, gelatin as raw material, uses circulating freezing resistance method to prepare hydrogel layer, and at water
Gel layer adds Rhizoma Coptidis, Flos Lonicerae extract, gives hydrogel anti-microbial property.Hydrogel layer is combined with backing layer, permissible
Keep the shape of hydrogel so that it is easy and skin attachement.Can be used for little area hurt, abrade, the polytype skin wound such as scuffing
The reparation of wound.
Summary of the invention
It is an object of the invention to provide a kind of hydrogel woundplast containing Chinese medicine extract and preparation method thereof, the present invention
Hydrogel woundplast there is anti-inflammation, hemostasia effect, wound fluid can be absorbed simultaneously, keep that wound surface is moistening, promote
Wound healing.
The purpose of the present invention is achieved through the following technical solutions:
A kind of hydrogel woundplast containing Chinese medicine extract, including backing layer and the hydrogel layer of backing layer one side laminating
And with hydrogel layer laminating peel ply, hydrogel layer is placed in backing layer centre position, and peel ply is placed on hydrogel layer；Institute
Stating backing layer is polyurethane film；The composition by weight percent of described hydrogel layer is: chitosan 0.5%-4.0%, polyvinyl alcohol
1.0%-3.0%, gelatin 0.2%-1.0%, glycerol 1.0%-3.0%, menthol 0.5%-2.5%, Rhizoma Coptidis extract
0.2%-1.0%, Flos Lonicerae extract 1.0%-2.5%, dehydrated alcohol 15%-25%, distilled water 50%-80%；Described stripping
Absciss layer is release paper.
Deacetylation >=95% of described chitosan, viscosity is 100-200mpa.s.
The alcoholysis degree of described polyvinyl alcohol is 87.0-89.0mol%, and viscosity is 20.5-24.5mpa.s.
The thickness of described hydrogel layer is 0.4-2.0mm.
The size of described peel ply is more than or equal to backing film layer.
Described a kind of hydrogel woundplast containing Chinese medicine extract, it is characterised in that the preparation of described Chinese medicine extract can
Comprise the following steps:
(1) Rhizoma Coptidis is pulverized, join soaked overnight in the ethanol solution that 12 times amount volume fractions are 60%, enter in 45 DEG C
The ultrasonic 1h of row, ultrasonic power is 250W, filters, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract；
(2) Flos Lonicerae is pulverized, join soaked overnight in the ethanol solution that 10 times amount volume fractions are 60%, in 40 DEG C
Carrying out ultrasonic 45min, ultrasonic power is 250W, filters, filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract.
The preparation method of described a kind of hydrogel woundplast containing Chinese medicine extract, it is characterised in that comprise the following steps:
(1) weigh chitosan, join in the acetum that mass concentration is 1.2% and dissolve；
(2) weighing polyvinyl alcohol, joins and carries out heating for dissolving in distilled water, cooling；
(3) weigh gelatin, join in distilled water, carry out swelling in 60 DEG C；
(4) weigh menthol, join in ethanol solution and dissolve；
(5) weigh Rhizoma Coptidis extract, join in the ethanol solution that volume fraction is 60% and dissolve；
(6) weigh Flos Lonicerae extract, join in the ethanol solution that volume fraction is 60% and dissolve；
(7) poly-vinyl alcohol solution, gelatin solution, menthol solutions, glycerol, Rhizoma Coptidis extract solution and Flos Lonicerae are extracted
Thing solution is added sequentially in chitosan solution in proportion, stirs；
(8) solution in (7) is circulated freezing thawing to process, forms hydrogel layer；
(9) polyurethane film of band pressure sensitive adhesive is affixed on the side of hydrogel layer, release paper is affixed on another of hydrogel layer
Side；
(10) it is sealed in packaging bag after hydrogel woundplast sterilizing.
The preferable parameter of described cryogenic treatment is: cryogenic temperature is-20 DEG C～-18 DEG C, the time be 6h～
12h；Melt temperature is 45 DEG C～55 DEG C, and the time is 0.5h～2h.
The present invention, with chitosan, polyvinyl alcohol, gelatin as raw material, uses circulating freezing resistance method to prepare hydrogel layer, has system
The advantages such as standby process simple, good biocompatibility, good mechanical performance；The present invention adds Rhizoma Coptidis and Flos Lonicerae extract, makes water
Gel adhesive bandage has anti-inflammation, hemostasia effect；Hydrogel layer is adhered on the polyurethane film of band pressure sensitive adhesive simultaneously, permissible
Reduce hydrogel moisture loss, and hydrogel and polyurethane film synergism, make hydrogel woundplast have good comfortable
Property.
In sum, a kind of hydrogel woundplast containing Chinese medicine extract of the present invention, there is anti-inflammation, hemostasis merit
Effect, will not produce drug resistance, and wound surface can be maintained to moisten with absorbing wound exudate, tissue adhesion will not occur, it is possible to have
Effect wound healing, shortens wound healing time.The hydrogel woundplast containing Chinese medicine extract of the present invention is applicable to little
The healing of the wound surface such as long-pending incised wound, scratch.
Accompanying drawing explanation
Fig. 1 is the inhibition zone test result figure of the hydrogel woundplast containing Chinese medicine extract of the present invention, and wherein, A is it
Inhibition figure to staphylococcus aureus；B is its inhibition figure to colon bacillus.
Fig. 2 is rat incised wound wound healing outside drawing (the 1st, 3,5,9 days)；Wherein A is that experimental group is (containing Chinese medicine extract water
Gel adhesive bandage group)；B is positive controls (benzalkonium bromide adhesive bandage group)；C is negative control group (gauze group).
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further described.
The preparation of Rhizoma Coptidis extract: pulverized by Rhizoma Coptidis, joins in the ethanol solution that 12 times amount volume fractions are 60% and soaks
Profit overnight, carries out ultrasonic 1h in 45 DEG C afterwards, and ultrasonic power is 250W, and filtrate is concentrated postlyophilization, obtains by filtered while hot
Rhizoma Coptidis extract, wherein content of berberine hydrochloride is 25.0%, and palmatine content is 6.0%, and the content of coptisine is 5.4%,
Epiberberine content is 3.8%；
The preparation of Flos Lonicerae extract: being pulverized by Flos Lonicerae, joining 10 times amount volume fractions is the ethanol solution of 60%
Middle infiltration overnight, carries out ultrasonic 45min in 40 DEG C, and ultrasonic power is 250W, and filtrate is concentrated postlyophilization by filtered while hot,
Obtaining Flos Lonicerae extract, its Content of Chlorogenic Acid is 5.4%.
Embodiment 1
(1) weigh 0.8g chitosan, join in the acetum that 36mL mass concentration is 1.2%, stir, formed
Solution A；
(2) weigh 1.0g polyvinyl alcohol, join and 15mL distilled water carries out heating for dissolving, stir, cooling, formed
Solution B；
(3) weigh 0.2g gelatin, join in 14mL distilled water, carry out swelling in 60 DEG C, form solution C；
(4) weigh 0.8g menthol, join in 5mL ethanol solution, stir, form solution D；
(5) weigh 0.2g Rhizoma Coptidis extract, join in the ethanol solution that 10mL volume fraction is 60%, stir,
Form solution E；
(6) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 20mL volume fraction is 60%, stirring is all
Even, form solution F；
(7) solution B, C, D, E, F and 0.8mL glycerol are added sequentially in solution A, and stir, form solution
G；
(8) solution G being circulated freezing thawing to process, cryogenic temperature is-18 DEG C, and the time is 12h, and melt temperature is 45
DEG C, the time is 1.5h, forms hydrogel layer；
(9) polyurethane film of band pressure sensitive adhesive is affixed on the side of hydrogel layer, release paper is affixed on another of hydrogel layer
Side；
(10) it is sealed in packaging bag after hydrogel woundplast sterilizing.
Embodiment 2
(1) weigh 1.6g chitosan, join in the acetum that 30mL mass concentration is 1.2%, stir, formed
Solution A；
(2) weigh 2.0g polyvinyl alcohol, join and 12mL distilled water carries out heating for dissolving, stir, cooling, formed
Solution B；
(3) weigh 0.6g gelatin, join in 12mL distilled water, carry out swelling in 60 DEG C, form solution C；
(4) weigh 1.6g menthol, join in 3mL ethanol solution, stir, form solution D；
(5) weigh 0.5g Rhizoma Coptidis extract, join in the ethanol solution that 20mL volume fraction is 60%, stir,
Form solution E；
(6) weighing 1.0g Flos Lonicerae extract, join in the ethanol solution that 20mL volume fraction is 60%, stirring is all
Even, form solution F；
(7) solution B, C, D, E, F and 1.2mL glycerol are added sequentially in solution A, and stir, form solution
G；
(8) solution G being circulated freezing thawing to process, cryogenic temperature is-18 DEG C, and the time is 12h, and melt temperature is 45
DEG C, the time is 1.5h, forms hydrogel layer；
(9) polyurethane film of band pressure sensitive adhesive is affixed on the side of hydrogel layer, release paper is affixed on another of hydrogel layer
Side；
(10) it is sealed in packaging bag after hydrogel woundplast sterilizing.
Embodiment 3
(1) weigh 3.0g chitosan, join in the acetum that 28mL mass concentration is 1.2%, stir, formed
Solution A；
(2) weigh 2.5g polyvinyl alcohol, join and 12mL distilled water carries out heating for dissolving, stir, cooling, formed
Solution B；
(3) weigh 0.8g gelatin, join in 9mL distilled water, carry out swelling in 60 DEG C, form solution C；
(4) weigh 2.0g menthol, join in 3mL ethanol solution, stir, form solution D；
(5) weigh 0.8g Rhizoma Coptidis extract, join in the ethanol solution that 20mL volume fraction is 60%, stir,
Form solution E；
(6) weigh 1.8g Flos Lonicerae extract, join the ethanol solution that 20mL volume fraction is 60%, stir,
Form solution F；
(7) solution B, C, D, E, F and 2.0mL glycerol are added sequentially in solution A, and stir, form solution
G；
(8) solution G being circulated freezing thawing to process, cryogenic temperature is-18 DEG C, and the time is 12h, and melt temperature is 45
DEG C, the time is 1.5h, forms hydrogel layer；
(9) polyurethane film of band pressure sensitive adhesive is affixed on the side of hydrogel layer, release paper is affixed on another of hydrogel layer
Side；
(10) it is sealed in packaging bag after hydrogel woundplast sterilizing.
The swelling behavior test of embodiment 4 hydrogel layer
Take hydrogel layer prepared by 2cm × 2cm embodiment 1-3, weigh, be designated as m0；It is then placed in 40mL distilled water,
Under room temperature condition (25 DEG C), take out at set intervals, blot the water of hydrogel surface with filter paper after, weigh and record.Treat to
After constant weight, weigh, be designated as m1.Swellbility=(m1-m0)/m0× 100%.The results are shown in Table 1.
Table 1 hydrogel layer swellbility test result
The water vapour permeability test of the embodiment 5 hydrogel woundplast containing Chinese medicine extract
Hydrogel woundplast prepared by Example 1-3, (area is to be covered the bottle mouth position at open vials
1.77cm2), wherein containing the anhydrous CaCl of 10g in bottle2, with teflin tape, bottleneck surrounding is sealed；Positive controls is adopted
With the bottle sealed, containing the anhydrous CaCl of 10g in bottle2；Negative control group use opening bottle, in bottle containing 10g without
Water CaCl2；Being placed in exsiccator by all bottles, wherein exsiccator is contained within saturated NaCl solution (its relative humidity is 70%
RH), exsiccator is placed in 37 DEG C of baking ovens, measures the quality of bottle in certain time interval, calculate water vapour permeability.Knot
Fruit is shown in Table 2.
The water vapour permeability test result of table 2 hydrogel woundplast
As known from Table 2, the water vapour permeability of experimental group be less than negative control group, therefore the present invention containing Chinese medicine extract
Hydrogel layer can effectively prevent moisture loss, maintain wound surface to moisten.
The fungistatic effect of the hydrogel woundplast containing Chinese medicine extract of embodiment 6 present invention
Prepared by sample: weigh 50mg Rhizoma Coptidis extract, joins in the ethanol solution that 10mL volume fraction is 60%, obtains
Rhizoma Coptidis extract medicinal liquid；Weigh 100mg Flos Lonicerae extract, join in the ethanol solution that 10mL volume fraction is 60%,
To Flos Lonicerae extract medicinal liquid.Hydrogel solution prepared by Example 1-3.
Strain selects: represent gram with staphylococcus aureus (Staphylococcus aureus ATCC29213)
Positive bacteria, colon bacillus (Escherichia coli ATCC25922) represents gram negative bacteria, is purchased from Jiangsu Province's health
China medical sci-tech industry center.
Culture medium: bacteria culture media be pH value be the nutrient agar of 7.2 ± 0.2.Culture medium is bought in Beijing three
Medicine scientific and technological development company.
Assay method: by the inhibition zone size of the hydrogel layer in Beating holes method mensuration embodiment 1-3, pass judgment on the present invention
The bacteriostatic activity of the hydrogel woundplast containing Chinese medicine extract.The bacteria suspension (10 that 2mL is diluted8Cfu/mL) water-bath is joined
Under the conditions of (50 DEG C) 200mL liquid culture medium in, and mix homogeneously.Above-mentioned for the 20mL media transfer being mixed with bacteria suspension is arrived
(clump count is 10 to make it solidify in culture dish6-107cfu/mL).On flat board, get 3 holes with card punch, be evenly distributed, away from
While be 1.5cm, with sterilizing toothpick, agar block is chosen, flame back cover.70 μ L liquid to be measured are injected in each hole, cultivate in 37 DEG C
24h.Inhibition zone measurement result is shown in Fig. 1.Antibacterial circle diameter test result is shown in Table 3.
The table 3 hydrogel woundplast antibacterial circle diameter containing Chinese medicine extract
As known from Table 3, Rhizoma Coptidis all has good inhibiting effect, Flos Lonicerae to staphylococcus aureus and colon bacillus
Extract is better than the inhibition to colon bacillus to the inhibition of staphylococcus aureus；The present invention carries containing Chinese medicine
Take the hydrogel woundplast of thing compared with Chinese medicine extract, remain the fungistatic effect of Chinese medicine extract, and along with Chinese medicine extraction
Increasing of thing content, its fungistatic effect also strengthens.
The hydrogel woundplast containing Chinese medicine extract of embodiment 7 present invention Healing to rat incised wound wound
Incised wound animal model: the male SD rat that experiment uses body weight to be 180-200g is (real purchased from Shanghai Jie Sijie animal
Test company limited), after adaptability raises one week, by rat anesthesia, carry out back depilation process with 8% sodium sulfide solution, and use
Warm water washes away the hair and depilatory taken off.After 24h, with ether by rat anesthesia, gently it is pressed on rat back after being sterilized by blade, draws
2mm is deep, and the long wound of 2cm is randomly divided into: positive controls (benzalkonium bromide adhesive bandage group), negative control group (gauze group), enforcement
Example 1 group, embodiment 2 groups, embodiment 3 groups, often group 6.Chinese medicine hydrogel woundplast, the benzene embodiment 1-3 prepared respectively are pricked
Bromine ammonium adhesive bandage, gauze are fixed on rat back, and every rat list cage is raised.Rat wound is changed a dressing, wound by every day
Latter the 1-9 days METHOD FOR CONTINUOUS DETERMINATION wound sizes also calculate wound healing rate.Rat incised wound wound healing outward appearance is shown in Fig. 2.Wound healing
Rate the results are shown in Table 4.
Table 4 respectively organize rat wound healing rate (N=6)
As known from Table 4, the hydrogel woundplast containing Chinese medicine extract of the present invention to rat incised wound wound healing rate with
Positive controls is close, and when the 9th day, rat wound healed substantially；Within the identical time, its healing rate is higher than negative control
Group (P ＜ 0.01), has significant significant difference.Therefore, the hydrogel woundplast containing Chinese medicine extract of the present invention is to rat
Incised wound wound has and significantly promotes Healing.
Claims (8)
1. the hydrogel woundplast containing Chinese medicine extract, it is characterised in that described hydrogel woundplast include backing layer and
Backing layer one side laminating hydrogel layer and with hydrogel layer laminating peel ply, hydrogel layer is placed in backing layer centre position,
Peel ply is placed on hydrogel layer；Described backing layer is polyurethane film；The composition by weight percent of described hydrogel layer is: shell
Polysaccharide 0.5%-4.0%, polyvinyl alcohol 1.0%-3.0%, gelatin 0.2%-1.0%, glycerol 1.0%-3.0%, menthol
0.5%-2.5%, Rhizoma Coptidis extract 0.2%-1.0%, Flos Lonicerae extract 1.0%-2.5%, dehydrated alcohol 15%-25%,
Distilled water 50%-80%；Described peel ply is release paper.
A kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that described chitosan
Deacetylation >=95%, viscosity is 100-200mpa.s.
A kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that described polyethylene
The alcoholysis degree of alcohol is 87.0-89.0mol%, and viscosity is 20.5-24.5mpa.s.
A kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that described hydrogel
The thickness of layer is 0.4-2.0mm.
A kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that described peel ply
Size more than or equal to backing film layer.
A kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that described Chinese medicine carries
The preparation taking thing can comprise the following steps that
(1) Rhizoma Coptidis is pulverized, joins soaked overnight in the ethanol solution that volume fraction is 60%, carry out ultrasonic 1h in 45 DEG C,
Ultrasonic power is 250W, filters, filtrate is concentrated postlyophilization, obtains Rhizoma Coptidis extract；
(2) Flos Lonicerae is pulverized, join soaked overnight in the ethanol solution that volume fraction is 60%, carry out ultrasonic in 40 DEG C
45min, ultrasonic power is 250W, filters, filtrate is concentrated postlyophilization, obtains Flos Lonicerae extract.
The preparation method of a kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 1, it is characterised in that
Comprise the following steps:
(1) weigh chitosan, join in the acetum that mass concentration is 1.2% and dissolve；
(2) weighing polyvinyl alcohol, joins and carries out heating for dissolving in distilled water, cooling；
(3) weigh gelatin, join in distilled water, carry out swelling in 60 DEG C；
(4) weigh menthol, join in ethanol solution and dissolve；
(5) weigh Rhizoma Coptidis extract, join in the ethanol solution that volume fraction is 60% and dissolve；
(6) weigh Flos Lonicerae extract, join in the ethanol solution that volume fraction is 60% and dissolve；
(7) by molten to poly-vinyl alcohol solution, gelatin solution, menthol solutions, glycerol, Rhizoma Coptidis extract solution and Flos Lonicerae extract
Liquid is added sequentially in chitosan solution in proportion, stirs；
(8) solution in (7) is circulated freezing thawing to process, forms hydrogel layer；
(9) polyurethane film of band pressure sensitive adhesive is affixed on the side of hydrogel layer, release paper is affixed on the opposite side of hydrogel layer；
(10) it is sealed in packaging bag after hydrogel woundplast sterilizing.
The preparation method of a kind of hydrogel woundplast containing Chinese medicine extract the most according to claim 7, it is characterised in that
The preferable parameter of described cryogenic treatment is: cryogenic temperature is-20 DEG C～-18 DEG C, and the time is 6h～12h；Melt temperature
Degree is 45 DEG C～55 DEG C, and the time is 0.5h～2h.
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| CN108379643A (en) * | 2018-02-13 | 2018-08-10 | 云南宁康生物科技有限公司 | A kind of hydrogel woundplast of the active constituent containing American cockroach |
| CN108392472A (en) * | 2018-04-23 | 2018-08-14 | 四川大学 | A kind of gel rubber plaster and preparation method containing Chinese medical extract |
| CN108310462A (en) * | 2018-04-25 | 2018-07-24 | 信阳师范学院 | A kind of preparation method of hydroxyethyl chitosan plural gel |
| CN108721688A (en) * | 2018-06-04 | 2018-11-02 | 界首市龙鑫生物科技有限公司 | A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract |
| CN109288820A (en) * | 2018-10-12 | 2019-02-01 | 河南名锐药业有限责任公司 | A kind of eye paste and preparation method thereof containing rosemary |
| CN110201102A (en) * | 2019-07-17 | 2019-09-06 | 湖北特必达生物医疗科技有限公司 | A kind of compound bio anti-biotic material and preparation method thereof |
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| CN115364274A (en) * | 2022-07-14 | 2022-11-22 | 贵州中医药大学 | Preparation and application of blood ginseng ethanol extract hydrogel |
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