CN108721688A - A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract - Google Patents
A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract Download PDFInfo
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- CN108721688A CN108721688A CN201810561498.7A CN201810561498A CN108721688A CN 108721688 A CN108721688 A CN 108721688A CN 201810561498 A CN201810561498 A CN 201810561498A CN 108721688 A CN108721688 A CN 108721688A
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- aerogel dressing
- fruit extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/008—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/41—Anti-inflammatory agents, e.g. NSAIDs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Abstract
The invention discloses one kind containing honeysuckle, the aerogel dressing preparation method of wolfberry fruit extract, utilize matrimony vine, Honegsukle flower P.E acts synergistically with nano zine oxide, one side extract can be wrapped in nano zine oxide surrounding, it can be stabilized, on the other hand, matrimony vine honeysuckle has the function of cytoprotection and promotees cell Proliferation, apparent antibacterial activity and anti-inflammatory effect, also have simultaneously hypoglycemic, lipid-loweringing, anti- mutagenesis, anti-aging, resist oxygen lack and to pharmacological actions such as the adjustings of endocrine hormone, it is applied to and applies dressing, it can be with synergic nano zinc oxide, enhance the antibacterial effect of aerogel dressing, promote wound healing simultaneously, it is anti-inflammatory；Chitosan solution is modified using nano zine oxide, improves the mechanical property of aerogel dressing, while increasing antibacterial effect.
Description
Technical field
The invention belongs to medical dressing technical fields, and in particular to a kind of hydrogel containing honeysuckle, wolfberry fruit extract is deposited
Preparation method for material.
Background technology
Hydrogel is a kind of high molecular polymer with three-dimensional structure, be crosslinked by hydrophilic high-molecular compound and
At can be swollen and keep large quantity of moisture and insoluble in water.Hydrogel is answered extensively due to its good biocompatibility
Used in bio-medical fields such as tissue filling agent, artificial skins.Lycium Solanaceae class plant has nearly quincentenary cultivation and goes through
History.
Contain multiple nutritional components in matrimony vine, such as abundant carbohydrate, protein, fat, alkaloid, amino acid, taurine,
Carotenoid etc. has effects that very high nutritive value and medicinal health.The Ministry of Public Health of China is formal in 1988 to announce matrimony vine
It is both food and drug, is the traditional integration of drinking and medicinal herbs type plant in China, while matrimony vine also has protection cell and antibacterial action.
But the prior art is applied to about by wolfberry fruit extract in hydrogel medical dressing, there is also dampening gel mechanics
Performance is relatively low while the inadequate distinct issues of its bactericidal effect.
Invention content
In view of the above-mentioned problems, the present invention is intended to provide a kind of bactericidal effect is notable, the good water-setting of hydrogel properties
Glue dressing preparation method.
The invention is realized by the following technical scheme：
A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract, includes the following steps：
（1）By 8-15 parts honeysuckle in parts by weight, 10-15 portions of matrimony vines, 1-2 parts of vitamin Cs, with distilled water flushing 1-2 times,
Surface dirt, impurity are removed, is then put it into freeze drier, -20~-30 DEG C of freeze-drying 1-3h take out, grinding
At powder, room temperature 1-2h is then placed in 40-60 DEG C of distilled water, using the supersound process 2-3h of 60-80Hz, then
3-5h is impregnated, filtrate is evaporated to volume-diminished to the 1/4-1/3 of original volume, it is spare to obtain extracting solution by filtering；
（2）10-20 parts of hectorites are put into vacuum drying chamber, 50-70 DEG C of dry 3-5h is added to its volume 10- after taking-up
In 20 times of distilled water, after stirring 1-2h under 400-800rpm rotating speeds, step is added（1）Gained extracting solution continues to stir 1-2h,
Obtain mixed liquor；
（3）In nitrogen atmosphere, 40-50 parts of modification of chitosan solution are added to by step with the rotating speed of 300-400rpm（2）Institute
It obtains in mixed liquor, continues after stirring 10-20min, 5-10 parts of citric acid solutions are added, be cooled to 2-4 DEG C, 3-5 parts of initiations are added
Agent, raising speed to 500-1000rpm after stirring 20-50min, are stored at room temperature reaction 1-2h, then heat to 70-75 DEG C, stand
10-20h is to get target aerogel dressing.
Further, step（3）The modification of chitosan solution is nano zinc oxide modified chitosan solution, preparation method
For：20-50 parts of chitosans are dissolved in glacial acetic acid aqueous solution, the solution of 3-5% is formed, 1-2 parts of Tween-80s and 4-6 parts are added
Nano zine oxide, the wherein grain size of nano zine oxide are 10-50nm, are stirred evenly under 300-700rpm.
Further, step（3）A concentration of 5-10% of citric acid solution.
Further, step（3）The initiator is ammonium persulfate.
Beneficial effects of the present invention：The present invention is acted synergistically using matrimony vine, Honegsukle flower P.E with nano zine oxide, a side
Face extract can be wrapped in nano zine oxide surrounding, can be stabilized, and on the other hand, matrimony vine honeysuckle protects with cell
Shield and the effect for promoting cell Proliferation, it will be apparent that antibacterial activity and anti-inflammatory effect, while also there is hypoglycemic, lipid-loweringing, anti-mutagenesis, resist
Aging, resist oxygen lack and to pharmacological actions such as the adjustings of endocrine hormone, are applied to using dressing, can be aoxidized with synergic nano
Zinc, enhances the antibacterial effect of aerogel dressing, while promoting wound healing, anti-inflammatory；Using nano zine oxide to chitosan solution
It is modified, improves the mechanical property of aerogel dressing, while increasing antibacterial effect；It is formed using hectorite and chitosan double
Network aqueous gel coordinates the presence of nano zine oxide, so that the mechanical property of gained aerogel dressing is greatly improved, while also enhancing
The bonded performance of hydrogel.
Specific implementation mode
Illustrate the present invention with specific embodiment below, but is not limitation of the present invention.
Embodiment 1
A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract, includes the following steps：
（1）By 8 portions of honeysuckles, 10 portions of matrimony vines, 1 vitamin C in parts by weight, with distilled water flushing 1 time, surface ash is removed
Dirt, impurity, then put it into freeze drier, and -20 DEG C of freeze-drying 1h take out, grind into powder, room temperature
1h is then placed in 40 DEG C of distilled water, using the supersound process 2h of 60Hz, then impregnates 3h, and filtrate is evaporated to body by filtering
Product is contracted to the 1/4 of original volume, and it is spare to obtain extracting solution；
（2）10 parts of hectorites are put into vacuum drying chamber, 50 DEG C of dry 3h are added to the distilled water of 10 times of its volume after taking-up
In, after stirring 1h under 400rpm rotating speeds, step is added（1）Gained extracting solution continues to stir 1h, obtains mixed liquor；
（3）In nitrogen atmosphere, 40 parts of modification of chitosan solution are added to by step with the rotating speed of 300rpm（2）Gained mixed liquor
In, continue after stirring 10min, 5 parts of citric acid solutions are added, be cooled to 2 DEG C, 3 parts of initiators are added, raising speed to 500rpm is stirred
After mixing 20min, it is stored at room temperature reaction 1h, then heats to 70 DEG C, stands 10h to get target aerogel dressing.
Further, step（3）The modification of chitosan solution is nano zinc oxide modified chitosan solution, preparation method
For：20 parts of chitosans are dissolved in glacial acetic acid aqueous solution, 3% solution is formed, 1 part of Tween-80 is added and 4 parts nano oxidized
Zinc, the wherein grain size of nano zine oxide are 10nm, are stirred evenly under 300rpm.
Further, step（3）The citric acid solution a concentration of 5%.
Further, step（3）The initiator is ammonium persulfate.
Embodiment 2
A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract, includes the following steps：
（1）By 10 portions of honeysuckles, 12 portions of matrimony vines, 2 parts of vitamin Cs in parts by weight, with distilled water flushing 2 times, surface is removed
Dust, impurity, then put it into freeze drier, and -25 DEG C of freeze-drying 2h take out, grind into powder, room temperature
2h is then placed in 50 DEG C of distilled water, using the supersound process 3h of 70Hz, then impregnates 4h, and filtrate is evaporated to body by filtering
Product is contracted to the 1/3 of original volume, and it is spare to obtain extracting solution；
（2）10-20 parts of hectorites are put into vacuum drying chamber, 60 DEG C of dry 4h are added to the steaming of 15 times of its volume after taking-up
In distilled water, after stirring 2h under 600rpm rotating speeds, step is added（1）Gained extracting solution continues to stir 2h, obtains mixed liquor；
（3）In nitrogen atmosphere, 45 parts of modification of chitosan solution are added to by step with the rotating speed of 350rpm（2）Gained mixed liquor
In, continue after stirring 15min, 6 parts of citric acid solutions are added, be cooled to 3 DEG C, 4 parts of initiators are added, raising speed to 800rpm is stirred
After mixing 40min, it is stored at room temperature reaction 2h, then heats to 72 DEG C, stands 15h to get target aerogel dressing.
Further, step（3）The modification of chitosan solution is nano zinc oxide modified chitosan solution, preparation method
For：40 parts of chitosans are dissolved in glacial acetic acid aqueous solution, 4% solution is formed, 2 parts of Tween-80s are added and 5 parts nano oxidized
Zinc, the wherein grain size of nano zine oxide are 30nm, are stirred evenly under 500rpm.
Further, step（3）The citric acid solution a concentration of 7%.
Further, step（3）The initiator is ammonium persulfate.
Embodiment 3
A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract, includes the following steps：
（1）By 15 portions of honeysuckles, 15 portions of matrimony vines, 2 parts of vitamin Cs in parts by weight, with distilled water flushing 2 times, surface is removed
Dust, impurity, then put it into freeze drier, and -30 DEG C of freeze-drying 3h take out, grind into powder, room temperature
2h is then placed in 60 DEG C of distilled water, using the supersound process 3h of 80Hz, then impregnates 5h, and filtrate is evaporated to body by filtering
Product is contracted to the 1/3 of original volume, and it is spare to obtain extracting solution；
（2）20 parts of hectorites are put into vacuum drying chamber, 70 DEG C of dry 5h are added to the distilled water of 20 times of its volume after taking-up
In, after stirring 2h under 800rpm rotating speeds, step is added（1）Gained extracting solution continues to stir 2h, obtains mixed liquor；
（3）In nitrogen atmosphere, 50 parts of modification of chitosan solution are added to by step with the rotating speed of 400rpm（2）Gained mixed liquor
In, continue after stirring 20min, 10 parts of citric acid solutions are added, are cooled to 4 DEG C, is added 5 parts of initiators, raising speed to 1000rpm,
After stirring 50min, it is stored at room temperature reaction 2h, then heats to 75 DEG C, stands 20h to get target aerogel dressing.
Further, step（3）The modification of chitosan solution is nano zinc oxide modified chitosan solution, preparation method
For：50 parts of chitosans are dissolved in glacial acetic acid aqueous solution, 5% solution is formed, 2 parts of Tween-80s are added and 6 parts nano oxidized
Zinc, the wherein grain size of nano zine oxide are 50nm, are stirred evenly under 700rpm.
Further, step（3）The citric acid solution a concentration of 10%.
Further, step（3）The initiator is ammonium persulfate.
Comparative example 1
The addition of honeysuckle, matrimony vine is omitted compared to embodiment 1 in this comparative example, and method and step in addition to this is homogeneous
Together.
Comparative example 2
The addition of nano zine oxide is omitted compared to embodiment 1 in this comparative example, and method and step in addition to this is homogeneous
Together.
Comparative example 3
The addition of hectorite is omitted compared to embodiment 1 in this comparative example, method and step all same in addition to this.
Experiment：
Water retention property is tested：After each group sample is swollen 40h in physiological saline, it is positioned over after spontaneously drying 100h in air
（Room temperature）, its moisture content is measured, and calculate water retention：Practical moisture content/Primogel of water retention=100% × hydrogel is aqueous
Rate.
Anti-microbial property test：It is that experimental bacteria carries out antibacterial that common staphylococcus aureus and Escherichia coli are chosen in this experiment
Experiment：By each group sample preparation at diameter 12mm, the oblate cylindricality of thick 2mm is positioned over and is coated with after ultraviolet sterilization
106On the agar medium of the bacterium solution of cfu/mL, culture dish is buckled to, is placed in 37 DEG C of constant incubator and cultivates for 24 hours, take out
Observe the growing state of inhibition zone.
Mechanics Performance Testing：Hydrogel obtained under the conditions of each group is made to the cylindrical sample of 1.4mL, a diameter of 15mm
Product are carried out Compressive Mechanical test to sample using omnipotent mechanics tester, are compressed with the rate of 1mm/min, until sample
Fracture.
Its test data is as shown in table 1：
Table 1
Nano zine oxide and honeysuckle, wolfberry fruit extract synergistic effect have good antibacterial effect, lithium soap it can be seen from table
The addition of stone can not only improve the mechanical property of aerogel dressing, while substantially increase the water retention property of aerogel dressing.
Claims (4)
1. a kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract, which is characterized in that include the following steps：
（1）By 8-15 parts honeysuckle in parts by weight, 10-15 portions of matrimony vines, 1-2 parts of vitamin Cs, with distilled water flushing 1-2 times,
Surface dirt, impurity are removed, is then put it into freeze drier, -20~-30 DEG C of freeze-drying 1-3h take out, grinding
At powder, room temperature 1-2h is then placed in 40-60 DEG C of distilled water, using the supersound process 2-3h of 60-80Hz, then
3-5h is impregnated, filtrate is evaporated to volume-diminished to the 1/4-1/3 of original volume, it is spare to obtain extracting solution by filtering；
（2）10-20 parts of hectorites are put into vacuum drying chamber, 50-70 DEG C of dry 3-5h is added to its volume 10- after taking-up
In 20 times of distilled water, after stirring 1-2h under 400-800rpm rotating speeds, step is added（1）Gained extracting solution continues to stir 1-2h,
Obtain mixed liquor；
（3）In nitrogen atmosphere, 40-50 parts of modification of chitosan solution are added to by step with the rotating speed of 300-400rpm（2）Institute
It obtains in mixed liquor, continues after stirring 10-20min, 5-10 parts of citric acid solutions are added, be cooled to 2-4 DEG C, 3-5 parts of initiations are added
Agent, raising speed to 500-1000rpm after stirring 20-50min, are stored at room temperature reaction 1-2h, then heat to 70-75 DEG C, stand
10-20h is to get target aerogel dressing.
2. a kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract according to claim 1, feature exist
In step（3）The modification of chitosan solution is nano zinc oxide modified chitosan solution, and preparation method is：By 20-50 parts of shells
Glycan is dissolved in glacial acetic acid aqueous solution, forms the solution of 3-5%, and 1-2 parts of Tween-80s and 4-6 parts of nano zine oxides are added,
The grain size of middle nano zine oxide is 10-50nm, is stirred evenly under 300-700rpm.
3. a kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract according to claim 1, feature exist
In step（3）A concentration of 5-10% of citric acid solution.
4. a kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract according to claim 1, feature exist
In step（3）The initiator is ammonium persulfate.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810561498.7A CN108721688A (en) | 2018-06-04 | 2018-06-04 | A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract |
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| CN201810561498.7A CN108721688A (en) | 2018-06-04 | 2018-06-04 | A kind of aerogel dressing preparation method containing honeysuckle, wolfberry fruit extract |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112521627A (en) * | 2020-10-14 | 2021-03-19 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112521627A (en) * | 2020-10-14 | 2021-03-19 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
| CN112521627B (en) * | 2020-10-14 | 2022-05-03 | 浙江树人学院（浙江树人大学） | Preparation method of green composite hydrogel with slow-release type purification and sterilization functions |
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