CN101069753A - Wound quick-healing plaster and preparing method - Google Patents
Wound quick-healing plaster and preparing method Download PDFInfo
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- CN101069753A CN101069753A CN 200610026379 CN200610026379A CN101069753A CN 101069753 A CN101069753 A CN 101069753A CN 200610026379 CN200610026379 CN 200610026379 CN 200610026379 A CN200610026379 A CN 200610026379A CN 101069753 A CN101069753 A CN 101069753A
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- oleum sesami
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Abstract
The present invention relates to a Chuangmian Suyutie adhesive plaster capable of promoting quick heating of the surface of wound and its preparation method. It is made up by using spun-laced nonwoven fabric or needle-punched nonwoven fabric with reticulate structure, impregnating said nonwoven fabric with sesame oil and beeswax medicinal mixture with sponge frame dosage form and adding self-sticking dressing pad.
Description
Technical field:
The present invention relates to contain the field of medical products of Pharmaceutical composition, particularly a kind of Wound quick-healing plaster and manufacture method thereof.
Background technology:
Wound healing be meant on the body since sick and wounded part that causes tissues such as skin of wound or other or holostrome damaged after, local organization is by regeneration and rebuild defective tissue is repaired a series of complexity of recovery and orderly biological process comprises that mainly inflammatory reaction, cell proliferation/connective tissue form, wound surface shrinks with reinvent several stages.The formation of wound surface and existence will produce great influence to the situation of body and even the function of whole body.Therefore, how accelerating the healing of wound surface, make defective tissue regaining one's integrity property as early as possible, callus is recovered fully or approaching original organizational structure, thereby guarantee to recover its function, is the necessary great problem in science that solves in wound healing research and the treatment.
Traditional medicine mainly is to use the dressing flap coverage to the processing of wound surface.Wound dressing is to prevent microbial contamination theoretically, mainly plays a kind of barrier action, and its design idea all is to absorb, get rid of wound exudate and the isolated effect of wound surface.Therefore, the research to dressing also mainly is to consider from biologically inert, avirulence and biocompatibility.Yet the dressing of this structure causes the more exsiccant environment of wound surface, makes the wound surface dehydration, causes incrustation.And the incrustation of wound surface has tangible obstacle to the epithelization of wound surface.
Therefore, Chinese invention patent description (Granted publication number: CN1045059C) disclose a kind of main treatment homoiothermic animal or human hot injury's Pharmaceutical composition.It is made up of following component: by the gross weight of described Pharmaceutical composition, 3～15% Cera Flava, with 85～97% the sesame oil extraction thing that contains Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris, wherein, described Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris do not account for 2～10% of Oleum sesami gross weight by its dried medicine weight score.This Pharmaceutical composition can keep wound surface moistening and do not flood; Going from the exterior into the interior ground liquefies in rejection and gets rid of the dead skin layer; Finish the adequate drainage on wound surface top layer between tissue with medicine; Ensure that by pharmaceutical formulation or other effect tissue behind the hot injury has the supply of lasting constant density active drug composition and drains outside wound surface; The air-isolation environment can in time be got rid of wound surface Excreta and metabolite simultaneously to the stimulation and the damage of wound surface.During use, above-mentioned composition is applied in wound surface gets final product.But this using method can't guarantee that medicine smears equably at wound surface, and a main feature of this medicine is in order to keep wound surface to have moistening treatment environment, therefore, after medicine is smeared, to be unfavorable for that the patient wears the clothes, takes action.
Summary of the invention:
Order of the present invention provides a kind of Wound quick-healing plaster and manufacture method thereof, solve the technical problem that the medicinal mixture of above-mentioned Oleum Sesami, Cera Flava of existing sponge formula framework dosage form effectively uses, improved the service efficiency of this Pharmaceutical composition and do not influenced the daily life of user.
For solving the problems of the technologies described above, the present invention is achieved in that
A kind of Wound quick-healing plaster is characterized in that: it is soaked to have the medicinal mixture of Oleum Sesami, Cera Flava of sponge formula framework dosage form by cancellated water thorn or needle punched non-woven fabrics, is equipped with the self-adhesive type dressing pad and constitutes.
The medicinal mixture of Oleum Sesami, Cera Flava of described sponge formula framework dosage form is by gross weight, 3～15% Cera Flava, with 85～97% the sesame oil extraction thing that contains Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris, wherein, described Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris do not account for 2～10% of Oleum sesami gross weight by its dried medicine weight score.
The preparation process of above-mentioned Wound quick-healing plaster is:
1. above-mentioned cancellated water thorn or needle punched non-woven fabrics are cut into suitable size;
But 2. above-mentioned Oleum Sesami, beeswax mixture are inserted in the heater with rustless steel or glass inwall;
But the heater that 3. will fill Oleum Sesami, beeswax mixture makes Oleum Sesami, beeswax mixture be flow-like 70～130 degrees centigrade of heating 10～30 minutes;
4. in the Oleum Sesami that the water of cutting has stung or the needle punched non-woven fabrics immersion has been heated, the beeswax mixture, flooded 10～30 minutes;
The water thorn or the needle punched non-woven fabrics that 5. will flood Oleum Sesami, beeswax mixture take out, and after static 10 minutes (not contacting with other object) under 10～25 degrees centigrade of environment, are placed in the plastic containers;
6. the Wound quick-healing plaster of preparation is packed.
Action principle of the present invention is:
One, moistening physiological environment:
Use " Wound quick-healing plaster " flap coverage, can between wound surface surface and dressing, form the fiber isolating membrane of layer of transparent.It is by the Ester on effective ingredient in the dressing and wound surface surface and ester-protein conjugates that plasma protein forms.This film has three big functions.1, the formation of physiology moist environment and maintenance.2, the fiber isolating membrane has the characteristic and the function of " semipermeable membrane ", can make between the water (wound tissue) of film both sides and the oil phase (Wound quick-healing plaster) and form osmotic gradient, various material compositions are exchanged with the ion pair stream mode: the metabolite of wound surface is excreted to the extexine of isolating membrane by osmosis, simultaneously, nutritional labeling in " Wound quick-healing plaster ", also be penetrated into the wound surface deep layer, to give full play to the effect that it promotes the histiocyte Regeneration and Repair by the fiber isolating membrane.3, stimulate epidermis cell and fibroblast proliferation, promote the epidermis cell migration.Simultaneously, wound surface does not produce incrustation under the moist environment, has accelerated the migration of epidermis cell, has shortened healing time.
Two, " three isolate " to wound tissue acts on:
" Wound quick-healing plaster " formed moistening physiological environment, can the effective isolation air to the damage of wound surface, secondary pollution that can the outer bound pair wound surface of effective isolation, simultaneously, the Oleum Sesami that dressing includes can slough, isolates the damage to wound surface of inflammatory exudate and other noxious substance.
Three, distinctive " respiratory metabolism " function:
" Wound quick-healing plaster " has unique compound configuration of " Webweb " 3 D stereo framework.Fluid in this framework configuration is the change state along with variations in temperature, forms fluid course, realizes the respiratory metabolism function of wound surface.Temperature at skin temperature turns under the usefulness, the oil droplet of temperatureization infiltrates wound surface, slough is divided into granule and it is held, thereby start hydrolysis, enzymolysis, become sour, a series of biochemical reaction such as saponification, fatization, esterification, the massive necrosis tissue of wound surface is hydrolyzed to little block organization, further enzymolysis is a small-molecule substance, consequent deleterious acidic materials through become sour and fat turn to nontoxic neutral substance, again by fatization, this reversible reaction of esterification, reach the toxicity that reduces the slough middle acid substance, alleviate continuation damage wound tissue.Simultaneously, reacted fluid loses lipotropy, combines with the slough of liquefaction, is discharged to the surface, and fresh fluid continues to infiltrate wound surface, begins new reaction repeated.
Make the present invention have following advantage by said structure:
1. can accelerate the healing of wound tissue;
2. be convenient to control mixture evenly, better play effectiveness in the coating of wound surface place;
3. easy to use.After the use, do not influence daily life, action.
The scope of application of the present invention is:
Skin donor site wound surface, scratch wound surface, various ulcer wound surface, bedsore wound, empyrosis wound surface and the various operation stitching edges of a knife etc.
The specific embodiment:
A kind of Wound quick-healing plaster is characterized in that: it is soaked to have the medicinal mixture of Oleum Sesami, Cera Flava of sponge formula framework dosage form by cancellated water thorn or needle punched non-woven fabrics, is equipped with the self-adhesive type dressing pad and constitutes.
The medicinal mixture of Oleum Sesami, Cera Flava of described sponge formula framework dosage form is by gross weight, 3～15% Cera Flava, with 85～97% the sesame oil extraction thing that contains Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris, wherein, described Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris do not account for 2～10% of Oleum sesami gross weight by its dried medicine weight score.
The preparation process of above-mentioned Wound quick-healing plaster is (replenish according to step, comprise relevant raw material and process conditions such as temperature range parameter)
1. above-mentioned cancellated water thorn or needle punched non-woven fabrics are cut into suitable size;
But 2. above-mentioned Oleum Sesami, beeswax mixture are inserted in the heater with rustless steel or glass inwall;
But the heater that 3. will fill Oleum Sesami, beeswax mixture makes Oleum Sesami, beeswax mixture be flow-like 70～130 degrees centigrade of heating 10～30 minutes;
4. in the Oleum Sesami that the water of cutting has stung or the needle punched non-woven fabrics immersion has been heated, the beeswax mixture, flooded 10～30 minutes;
The water thorn or the needle punched non-woven fabrics that 5. will flood Oleum Sesami, beeswax mixture take out,, after static 10 minutes (not contacting) under 10～25 degrees centigrade of environment, be placed in the plastic containers with other object;
6. the Wound quick-healing plaster of preparation is packed.
Being preferred embodiment of the present invention only in sum, is not to be used for limiting practical range of the present invention.Be that all equivalences of doing according to the content of the present patent application claim change and modification, all should be technology category of the present invention.
Claims (3)
1, a kind of Wound quick-healing plaster is characterized in that: it is soaked to have the medicinal mixture of Oleum Sesami, Cera Flava of sponge formula framework dosage form by cancellated water thorn or needle punched non-woven fabrics, is equipped with the self-adhesive type dressing pad and constitutes.
2, described Wound quick-healing plaster according to claim 1, it is characterized in that: the medicinal mixture of Oleum Sesami, Cera Flava of this sponge formula framework dosage form is by gross weight, 3～15% Cera Flava, with 85～97% the sesame oil extraction thing that contains Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris, wherein, described Radix Scutellariae, Rhizoma Coptidis, Cortex Phellodendri, Lumbricus and Pericarpium Papaveris do not account for 2～10% of Oleum sesami gross weight by its dried medicine weight score.
3, a kind of manufacture method of Wound quick-healing plaster as claimed in claim 1 or 2, its preparation process is:
1. above-mentioned cancellated water thorn or needle punched non-woven fabrics are cut into suitable size;
But 2. above-mentioned Oleum Sesami, beeswax mixture are inserted in the heater with rustless steel or glass inwall;
But the heater that 3. will fill Oleum Sesami, beeswax mixture makes Oleum Sesami, beeswax mixture be flow-like 70～130 degrees centigrade of heating 10～30 minutes;
4. in the Oleum Sesami that the water of cutting has stung or the needle punched non-woven fabrics immersion has been heated, the beeswax mixture, flooded 10～30 minutes;
The water thorn or the needle punched non-woven fabrics that 5. will flood Oleum Sesami, beeswax mixture take out, and after static 10 minutes (not contacting with other object) under 10～25 degrees centigrade of environment, are placed in the plastic containers;
6. the Wound quick-healing plaster of preparation is packed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200610026379 CN101069753A (en) | 2006-05-09 | 2006-05-09 | Wound quick-healing plaster and preparing method |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200610026379 CN101069753A (en) | 2006-05-09 | 2006-05-09 | Wound quick-healing plaster and preparing method |
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| CN101069753A true CN101069753A (en) | 2007-11-14 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010060362A1 (en) * | 2008-11-26 | 2010-06-03 | Rongxiang Xu | Dressing for accelerating wound healing and method of use and manufacture thereof |
| CN102188744A (en) * | 2011-05-10 | 2011-09-21 | 上海美宝生命科技有限公司 | Wound and ulcer paste |
| CN102258608A (en) * | 2011-06-29 | 2011-11-30 | 李俊刚 | Spraying agent for treating burn wounds |
| EP2362777A4 (en) * | 2009-08-20 | 2012-08-22 | Rongxiang Xu | Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer |
| CN105963797A (en) * | 2016-06-08 | 2016-09-28 | 成都森科制药有限公司 | Anti-bonding agent and preparation process thereof |
| CN106075538A (en) * | 2016-06-08 | 2016-11-09 | 成都森科制药有限公司 | Adhesion protective oil sliver and manufacture craft thereof |
| CN107137435A (en) * | 2017-04-26 | 2017-09-08 | 北京荣祥再生医学研究所有限公司 | A kind of anal intestine postoperative care composition and its production and use |
| CN110339389A (en) * | 2019-07-08 | 2019-10-18 | 生升美高科技(武汉)有限责任公司 | A kind of oiliness surface of a wound application and preparation method thereof |
| CN116327837A (en) * | 2023-04-25 | 2023-06-27 | 北京荣祥再生医学研究所有限公司 | Composition and application thereof in preparation of medicines for inhibiting cyclin D1 |
-
2006
- 2006-05-09 CN CN 200610026379 patent/CN101069753A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010060362A1 (en) * | 2008-11-26 | 2010-06-03 | Rongxiang Xu | Dressing for accelerating wound healing and method of use and manufacture thereof |
| EP2362777A4 (en) * | 2009-08-20 | 2012-08-22 | Rongxiang Xu | Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer |
| US9814750B2 (en) | 2009-08-20 | 2017-11-14 | Rongxiang Xu | Use of pharmaceutical compositions in preparing pharmaceuticals for treating diabetic ulcer |
| CN102188744A (en) * | 2011-05-10 | 2011-09-21 | 上海美宝生命科技有限公司 | Wound and ulcer paste |
| CN102258608A (en) * | 2011-06-29 | 2011-11-30 | 李俊刚 | Spraying agent for treating burn wounds |
| CN105963797A (en) * | 2016-06-08 | 2016-09-28 | 成都森科制药有限公司 | Anti-bonding agent and preparation process thereof |
| CN106075538A (en) * | 2016-06-08 | 2016-11-09 | 成都森科制药有限公司 | Adhesion protective oil sliver and manufacture craft thereof |
| CN107137435A (en) * | 2017-04-26 | 2017-09-08 | 北京荣祥再生医学研究所有限公司 | A kind of anal intestine postoperative care composition and its production and use |
| CN110339389A (en) * | 2019-07-08 | 2019-10-18 | 生升美高科技(武汉)有限责任公司 | A kind of oiliness surface of a wound application and preparation method thereof |
| CN116327837A (en) * | 2023-04-25 | 2023-06-27 | 北京荣祥再生医学研究所有限公司 | Composition and application thereof in preparation of medicines for inhibiting cyclin D1 |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20071114 |