CN1986002A - Preparing method of liquid hemostatic silicone rubber dressing - Google Patents
Preparing method of liquid hemostatic silicone rubber dressing Download PDFInfo
- Publication number
- CN1986002A CN1986002A CN 200610161520 CN200610161520A CN1986002A CN 1986002 A CN1986002 A CN 1986002A CN 200610161520 CN200610161520 CN 200610161520 CN 200610161520 A CN200610161520 A CN 200610161520A CN 1986002 A CN1986002 A CN 1986002A
- Authority
- CN
- China
- Prior art keywords
- silicone rubber
- elastomer
- dressing
- component
- calcium alginate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002379 silicone rubber Polymers 0.000 title claims abstract description 21
- 239000004945 silicone rubber Substances 0.000 title claims abstract description 21
- 230000002439 hemostatic effect Effects 0.000 title claims abstract description 10
- 239000007788 liquid Substances 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title description 5
- 229920001971 elastomer Polymers 0.000 claims abstract description 21
- 239000000806 elastomer Substances 0.000 claims abstract description 20
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 12
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 12
- 239000000648 calcium alginate Substances 0.000 claims abstract description 12
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 239000002250 absorbent Substances 0.000 claims abstract description 7
- 230000002745 absorbent Effects 0.000 claims abstract description 7
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 5
- 230000001954 sterilising effect Effects 0.000 claims abstract description 5
- 239000012530 fluid Substances 0.000 claims description 13
- 239000004744 fabric Substances 0.000 claims description 6
- 229920006221 acetate fiber Polymers 0.000 claims description 4
- 229910017052 cobalt Inorganic materials 0.000 claims description 4
- 239000010941 cobalt Substances 0.000 claims description 4
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 4
- 238000004659 sterilization and disinfection Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 2
- 230000023597 hemostasis Effects 0.000 abstract description 4
- 230000029663 wound healing Effects 0.000 abstract description 2
- 239000012876 carrier material Substances 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 9
- 208000027418 Wounds and injury Diseases 0.000 description 9
- 210000000589 cicatrix Anatomy 0.000 description 4
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000001125 extrusion Methods 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229920002529 medical grade silicone Polymers 0.000 description 1
- 239000012982 microporous membrane Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses preparation process of liquid hemostatic silicone rubber dressing. Through extruding the liquid hemostatic silicone rubber dressing including two components, component A and component B, in certain ratio determined on the requirement in viscosity, smoothness and softness onto carrier material of non-woven fabric or absorbent gauze to form elastomer; adding carboxy methyl chitosan, calcium alginate and CMC after the elastomer is cured; and Co-60 degradation and sterilizing, super strong absorbing hemostatic elastomer dressing is prepared. It is used in post-operational protection, and can reach the functions of absorbing effusion, hemostasis, bacteriostasis, promoting wound healing and reducing scar.
Description
Technical field
The present invention relates to a kind of manufacture method of medical dressing.
Background technology
At present clinically at wound care, all be to adopt common absorbent carbasus, microporous membrane to wait nuring wound, this method is more to some transudates, the irregular position of wound surface, need a large amount of sepages that absorb, consume a large amount of common absorbent carbasuss, and easily make when not noting wound produce cicatrix.
Summary of the invention
For addressing the above problem, thereby the invention provides the elastomer that adds carboxymethyl chitosan, calcium alginate, CMC on a kind of elastomer after adopting fluid silicone rubber to solidify, forms according to the degraded sterilization through the cobalt 6o width of cloth reach hemostasis, antibiotic, promote wound healing, a kind of preparation method of liquid hemostatic silicone rubber dressing of minimizing cicatrix.
A kind of preparation method of liquid hemostatic silicone rubber dressing of the present invention, it is by the A of fluid silicone rubber, B component, be equipped with by required viscosity and level and smooth, soft requirement, stirring, being squeezed in by acetate fiber non-woven fabrics, medical adhesive-bonded fabric or absorbent carbasus is the elastomer that forms on the material of carrier; After waiting for that elastomer solidifies, the elastomer superabsorbent bleeding-stopping dressing that on elastomer, adds carboxymethyl chitosan, calcium alginate, CMC again, forms through cobalt degraded sterilization.
The weight ratio of fluid silicone rubber is: A component 100, B component 40-100.Adding the thing weight ratio on the elastomer is: carboxymethyl chitosan 100-120: calcium alginate 30-40: CMC20-30.It is the 5000-15000 centipoise that fluid silicone rubber should be selected its viscosity of medical grade for use, and carboxymethyl chitosan, calcium alginate and CMC particle diameter should be the 500-800 order.Thickness after fluid silicone rubber solidifies should be 0.1-0.25mm.
Have ventilatively, level and smooth after the elastomer of contained fluid silicone rubber solidifies in the liquid hemostatic silicone rubber dressing, softness and tool better elastic reduce the effect of cicatrix.Compliance is arranged preferably and do not damage wound surface.Calcium alginate contacts the back calcium alginate with wound active function can be dissolved in the sepage through biodegradation, makes dressing form moistening gel, makes wound keep moistening, and dressing and wound also keep peeling off state fully, and prevent teleneuron death.Chitosan has played hemostasis, antimicrobial effect.Be used for the absorption, reparation to wound fluid, antibiotic, hemostasis, suppress the hypertrophy of cicatrix simultaneously, because its flexibility.
Specific implementation method
With liquid medical grade silicon rubber A component in proportion 100 and the B component in proportion 40-100 be provided under the per minute 800-1500 rotating speed and stir, making its viscosity is the 5000-15000 centipoise, after more evenly extrusion coated on acetate fiber non-woven fabrics, other medical adhesive-bonded fabric or absorbent carbasus, form elastomer, this operation must be finished in 60 minutes after A, the B set of dispense of fluid silicone rubber are got ready.Elastomer to be formed is again placed and is waited for that on one side curing after 2-6 hour, makes its THICKNESS CONTROL at 0.-1-0.25mm, and surface smoothing is inviscid.Again the A of fluid silicone rubber component in proportion 100 and the B component in proportion 40-100 be equipped with stir after again in 60 minutes evenly extrusion coated on the elastomer that forms on acetate fiber non-woven fabrics or other medical adhesive-bonded fabric, the absorbent carbasus, add by carboxymethyl chitosan 100-120: the mixture of calcium alginate 30-40: CMC20-30 compresses with pressure roller and makes its being bonded on the elastomer tightly, solidify more than 24 hours, after treating completion of cure, can take out and cut into all size, model, through the cobalt 6o width of cloth according to degraded sterilization a kind of liquid hemostatic silicone rubber dressing.Carboxymethyl chitosan, calcium alginate and CMC particle diameter should be the 500-800 order.
Claims (5)
1, a kind of preparation method of liquid hemostatic silicone rubber dressing, it is by the A of fluid silicone rubber, B component, be equipped with by required viscosity and level and smooth, soft requirement, stirring, being squeezed in by acetate fiber non-woven fabrics, medical adhesive-bonded fabric or absorbent carbasus is the elastomer that forms on the material of carrier; After waiting for that elastomer solidifies, the elastomer superabsorbent bleeding-stopping dressing that on elastomer, adds carboxymethyl chitosan, calcium alginate, CMC again, forms through cobalt degraded sterilization.
2, according to the described preparation method of claim 1, it is characterized in that the weight ratio of fluid silicone rubber is: A component 100, B component 40-100.
3, according to the described preparation method of claim 1, it is characterized in that adding on the elastomer thing weight ratio and be: carboxymethyl chitosan 100-120: calcium alginate 30-40:CMC20-30.
4, according to the described preparation method of claim 1, it is characterized in that it is the 5000-15000 centipoise that fluid silicone rubber should be selected its viscosity of medical grade for use, carboxymethyl chitosan, calcium alginate and CMC particle diameter should be the 500-800 order.
5,, it is characterized in that the thickness after fluid silicone rubber solidifies should be 0.1-0.25mm according to the described preparation method of claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101615206A CN100518835C (en) | 2006-12-27 | 2006-12-27 | Preparing method of liquid hemostatic silicone rubber dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2006101615206A CN100518835C (en) | 2006-12-27 | 2006-12-27 | Preparing method of liquid hemostatic silicone rubber dressing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1986002A true CN1986002A (en) | 2007-06-27 |
| CN100518835C CN100518835C (en) | 2009-07-29 |
Family
ID=38183031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101615206A Active CN100518835C (en) | 2006-12-27 | 2006-12-27 | Preparing method of liquid hemostatic silicone rubber dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100518835C (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102015012A (en) * | 2008-02-29 | 2011-04-13 | 普拉罗美德公司 | Local embolization via heating of thermosensitive polymers |
| CN103735363A (en) * | 2013-12-19 | 2014-04-23 | 褚加冕 | Manufacturing method for medical high-hygroscopicity hemostasis dressing |
| CN104758977A (en) * | 2014-10-11 | 2015-07-08 | 河南亚都实业有限公司 | An alginate dressing for treating bedsore and a preparing method thereof |
| US20160262944A1 (en) * | 2014-03-11 | 2016-09-15 | Kast Silicon Ltd. | Silicone strip |
| CN107412841A (en) * | 2017-08-09 | 2017-12-01 | 江西高大生物医疗科技有限公司 | A kind of production method of medical tea oil dressing |
| CN108016746A (en) * | 2017-12-06 | 2018-05-11 | 上海唐科新型包装材料有限公司 | A kind of film |
| CN109646702A (en) * | 2019-01-22 | 2019-04-19 | 江西乐丰医疗科技股份有限公司 | A kind of dressing of strong applicability and portable and effective |
| CN113456877A (en) * | 2021-07-09 | 2021-10-01 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5897517A (en) * | 1996-10-29 | 1999-04-27 | Alps South Corporation | Fabric reinforced elastomer materials |
| CN2621642Y (en) * | 2003-05-27 | 2004-06-30 | 宋鸿谟 | Dressing sheeet having irregular honeycomb-like opening |
| CN100413544C (en) * | 2005-05-13 | 2008-08-27 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
-
2006
- 2006-12-27 CN CNB2006101615206A patent/CN100518835C/en active Active
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102015012A (en) * | 2008-02-29 | 2011-04-13 | 普拉罗美德公司 | Local embolization via heating of thermosensitive polymers |
| CN103735363A (en) * | 2013-12-19 | 2014-04-23 | 褚加冕 | Manufacturing method for medical high-hygroscopicity hemostasis dressing |
| US20160262944A1 (en) * | 2014-03-11 | 2016-09-15 | Kast Silicon Ltd. | Silicone strip |
| CN104758977A (en) * | 2014-10-11 | 2015-07-08 | 河南亚都实业有限公司 | An alginate dressing for treating bedsore and a preparing method thereof |
| CN107412841A (en) * | 2017-08-09 | 2017-12-01 | 江西高大生物医疗科技有限公司 | A kind of production method of medical tea oil dressing |
| CN108016746A (en) * | 2017-12-06 | 2018-05-11 | 上海唐科新型包装材料有限公司 | A kind of film |
| CN109646702A (en) * | 2019-01-22 | 2019-04-19 | 江西乐丰医疗科技股份有限公司 | A kind of dressing of strong applicability and portable and effective |
| CN113456877A (en) * | 2021-07-09 | 2021-10-01 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
| CN113456877B (en) * | 2021-07-09 | 2023-04-11 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100518835C (en) | 2009-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: ROOSIN MEDICAL CO.,LTD. Assignor: Chu Shengwu Contract fulfillment period: 2009.7.3 to 2017.7.3 Contract record no.: 2009320001244 Denomination of invention: Preparing method of liquid hemostatic silicone rubber dressing Granted publication date: 20090729 License type: Exclusive license Record date: 20090724 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2009.7.3 TO 2017.7.3; CHANGE OF CONTRACT Name of requester: TAIZHOU CITY RONGXING ANTI-STICKY DUODERM CO., LTD Effective date: 20090724 |
|
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: ROOSIN MEDICAL CO.,LTD. Assignor: Chu Shengwu Contract record no.: 2009320001244 Date of cancellation: 20150420 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| ASS | Succession or assignment of patent right |
Owner name: TAIZHOU RONGXING MEDICAL SUPPLIES CO., LTD. Free format text: FORMER OWNER: CHU SHENGWU Effective date: 20150624 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20150624 Address after: 225321 Taizhou, Jiangsu Port Industrial Park, Far East Avenue, No. 8 Patentee after: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Address before: 225321 No. 18 Chun Jiang Road, Taizhou high port town, Jiangsu, China Patentee before: Chu Shengwu |
|
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20070627 Assignee: Shanghai Hengkai Trading Co.,Ltd. Assignor: TAIZHOU ROOSIN MEDICAL PRODUCT CO.,LTD. Contract record no.: X2024980018225 Denomination of invention: Preparation method of liquid silicone rubber hemostatic dressing Granted publication date: 20090729 License type: Common License Record date: 20241012 |